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RT) Target Volume Definition for Malignant Peripheral Nerve Sheath Tumor (MPNST

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RT) Target Volume Definition for Malignant Peripheral Nerve Sheath Tumor (MPNST Research Article ISSN: 2574 -1241 DOI: 10.26717/BJSTR.2021.34.005549 Impact of Multimodality Imaging to Improve Radiation Therapy (RT) Target Volume Definition for Malignant Peripheral Nerve Sheath Tumor (MPNST) Ferrat Dincoglan*, Omer Sager, Selcuk Demiral and Murat Beyzadeoglu Department of Radiation Oncology, University of Health Sciences, Gulhane Medical Faculty, Ankara, Turkey *Corresponding author: Ferrat Dincoglan, Department of Radiation Oncology, University of Health Sciences, Gulhane Medical Faculty, Ankara, Turkey ARTICLE INFO ABSTRACT Received: March 01, 2021 Objective: radiation delivery for malignant peripheral nerve sheath tumor (MPNST). Radiation Published: March 08, 2021 therapy (RT) planning Extensive for effort MPNST has isbeen typically focused based on improvingon computed the tomographytoxicity profile (CT)- of simulation. Nevertheless, incorporation of supplementary imaging modalities may offer great potential for improving radiotherapeutic management. Herein, we evaluated the Citation: Ferrat D, Omer S, Selcuk D, Murat B. Impact of Multimodality Imaging to Improve Radiation Therapy (RT) impactMaterials of multimodality and Methods: imaging to improve RT target volume definition for MPNST. of magnetic resonance imaging (MRI) or by use of the CT-simulation images only has Peripheral Nerve Sheath Tumor (MPNST). been comparatively assessed. RTGround target truth volume target definition volume forwhich MPNST has beenwith utilizedincorporation as the BiomedTarget VolumeJ Sci &Definition Tech Res for 34(3)-2021. Malignant reference for actual treatment and comparison purposes was thoroughly determined BJSTR. MS.ID.005549. review, collaboration, and ultimate consensus. Keywords: Malignant Peripheral Nerve by the board certified radiation oncologists after meticulous evaluation, colleague peer Sheath Tumor; Radiation Therapy; Mag- Results: RT planning has been accomplished by use of precise treatment planning netic Resonance Imaging systems at our tertiary referal institution. Primary objectives of RT planning included adequate coverage of target volumes with optimal sparing of critical structures. Synergy Abbreviations: MPNST: Malignant Pe- ripheral Nerve Sheath Tumor; RT: Radia- (Elekta, UK) Linear Accelerator has been utilized for delivery of irradiation. Results of tion Therapy; MRI: Magnetic Resonance our study revealed that ground truth target volume was identical with target volume Imaging; CT: Computed Tomography; determination with CT-MR fusion based imaging. IMRT: Intensity Modulated Radiation Conclusion: Therapy; IGRT: Image Guided Radiation Therapy; ART: Adaptive Radiation Ther- is strongly recommended RT target fordefinition improved composes accuracy an andindispensable precision aspectin radiotherapeutic of successful apy; BART: Breathing Adapted Radiation managementradiotherapeutic of MPNST management despite for the MPNST. need for Incorporation further supporting of MRI in evidence. target volume definition Therapy Introduction of symptoms depending on lesion location and proximity to critical neurovascular structures. An enlarging mass may be present Malignant peripheral nerve sheath tumor (MPNST) is a with weakness, paresthesia, and pain symptoms. Surgery, RT, and rare subtype of soft tissue sarcoma originating from the cells systemic agents are among the therapeutic options with ongoing of peripheral nerve sheaths, and a relatively poor prognosis extensive research for optimal management of MPNST [7-11]. RT may be associated with MPNST due to the risk of recurrence has been utilized for management of selected patients with MPNST and metastasis [1-6]. Both children and adults may be affected [9-11]. However, radiation induced adverse effects constitute a with MPNST, and an association has been found between neuro formidable challenge in management of MPNST with RT. Within this context, extensive effort has been focused on improving the toxicity therapy (RT) history may be associated with MPNST development fibromatozis type 1 and MPNST development. Also, prior radiation in some patients. Patients with MPNST may suffer from a plethora based on computed tomography (CT)-simulation. Nevertheless, profile of radiation delivery. RT planning for MPNST is typically Copyright@ Ferrat Dincoglan | Biomed J Sci & Tech Res | BJSTR. MS.ID.005549. 26734 Volume 34- Issue 3 DOI: 10.26717/BJSTR.2021.34.005549 incorporation of supplementary imaging modalities may offer great Radiation Therapy (IMRT), Image Guided Radiation Therapy (IGRT), potential for improving radiotherapeutic management. Herein, Adaptive Radiation Therapy (ART), Breathing Adapted Radiation we evaluated the impact of multimodality imaging to improve RT Therapy (BART), automatic segmentation methods, molecular imaging techniques, and stereotactic irradiation strategies [12-46]. Regarding radiotherapeutic management of MPNST, good response Materialstarget volume and definition Methods for MPNST. to therapy and promising outcomes have been reported [9-11]. Nevertheless, there is still room for improvements for further magnetic resonance imaging (MRI) or by use of the CT-simulation substantiating the role of RT in MPNST management. Adverse effects RT target volume definition for MPNST with incorporation of images only has been comparatively assessed. Ground truth of irradiation constitute a critical concern over radiotherapeutic target volume which has been utilized as the reference for actual management of patients particularly at earlier ages of their lifespan. treatment and comparison purposes was thoroughly determined A pertinent goal of RT may thus include minimized exposure of normal tissues which may be achieved through incorporation of evaluation, colleague peer review, collaboration, and ultimate by the board certified radiation oncologists after meticulous consensus. Personalized assessment included the lesion location IGRT techniques. RT target definition is a very critical component and volume, symptomatology, preferences, and projected outcomes in terms of tumor control and toxicity. While irradiation of larger of management which may significantly affect treatment outcomes of radiotherapeutic management for all patients. CT-simulator (GE target volumes may result in increased adverse RT effects, targeting Lightspeed RT, GE Healthcare, Chalfont St. Giles, UK) available at our of smaller volumes may lead to treatment failure. department has been utilized for RT planning. Acquired planning CT images have been transferred to the contouring workstation (SimMD, GE, UK) via the network for precise delineation of target At this point, accuracy and precision in RT target definition simulation for RT planning. However, multimodality imaging volumes and critical structures in close vicinity of the target. becomes crucial. Typical RT workflow includes utilization of CT- with incorporation of MRI may offer several advantages including Either CT-simulation images only or fused CT and MR images have detailed characterization of growth pattern, growth dynamics and disease extent as addressed in a critical review by Salamon, et al. been used in definition of target volumes for radiotherapeutic [47]. Several other studies have also investigated multimodality incorporation of CT-MR fusion has been comparatively assessed. management. Target volume definition with CT only and with Results imaging based target volume definition for other tumors [48-67]. In successful radiotherapeutic management for MPNST. Incorporation RT planning has been accomplished by use of precise treatment conclusion, RT target definition composes an indispensable aspect of planning systems at our tertiary referral institution. Primary improved accuracy and precision in radiotherapeutic management objectives of RT planning included adequate coverage of target of MRI in target volume definition is strongly recommended for of MPNST despite the need for further supporting evidence. the ground truth target volume has been meticulously performed volumes with optimal sparing of critical structures. Definition of References 1. Xu Y, Xu G, Liu Z, Duan J, Lin Y, et al. (2021) Incidence and prognosis evaluation, colleague peer review, collaboration and ultimate of distant metastasis in malignant peripheral nerve sheath tumors. Acta by the board certified radiation oncologists following thorough consensus to be utilized for actual treatment and for comparative Neurochir 163(2): 521-529. analysis. Synergy (Elekta, UK) Linear Accelerator has been utilized 2. Meister MT, Scheer M, Hallmen E, Stegmaier S, Vokuhl C, et al. (2020) Malignant peripheral nerve sheath tumors in children, adolescents, and imaging and by CT-MR fusion based imaging has been evaluated Studiengruppe (CWS) trials and one registry. J Surg Oncol 122(7): 1337- for delivery of irradiation. Target volume definition by CT-only young adults: Treatment results of five Cooperative Weichteilsarkom comparatively. Results of our study revealed that ground truth 1347. target volume was identical with target volume determination with 3. Scheithauer BW, Erdogan S, Rodriguez FJ, Burger PC, Woodruff JM, et al. (2009) Malignant peripheral nerve sheath tumors of cranial nerves and CT-MR fusion based imaging. intracranial contents: a clinicopathologic study of 17 cases. Am J Surg Pathol 33(3): 325-338. Discussion 4. Van Noesel MM, Orbach D, Brennan B, Kelsey A, Zanetti I, et al. (2019) MPNST may have potential for recurrence and metastasis Outcome and prognostic factors in pediatric malignant peripheral which may portend a grim prognosis
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