Who Was the Perpetrator?
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Progress Report on a Pandemic
The international journal of science / 20 August 2020 other diseases were more likely to be admitted to intensive care, whereas children seemed to have milder disease4. Progress report But it quickly became apparent that SARS-CoV-2 is not just a respiratory virus. It also affects blood vessels, causing on a pandemic thrombosis5 and strokes6. Autopsies have found the virus in organs other than the lungs, including the kidneys, liver, heart and brain, In the first of a series of editorials, we as well as in the blood7. We now know that symptoms of look back at some of the key findings COVID-19 can include gastrointestinal, neurological, renal, from scientists’ race to demystify the new cardiovascular and other complications8. coronavirus. Something in the air n the space of eight months, the new coronavirus It soon became clear that SARS-CoV-2 could hop from SARS-CoV-2 and the disease it causes, COVID-19, have one person to another. This could happen through direct dominated the work of thousands of researchers in an contact or indirect transmission, such as through drop- unprecedented global effort. lets expelled during a cough, or even a simple exhalation. In a series of editorials, we look back at key scientific What wasn’t clear — and is still a matter of debate — is how Ifindings that have revealed important characteristics of big those droplets need to be, and how far they can travel. the virus and COVID-19, including emerging approaches to It’s an important question. Larger droplets will quickly treatment and prevention. We begin, this week, with how fall to the ground, but smaller, lighter ones — known as aer- the virus was identified; how it transmits between people; osols — can stay suspended in the air. -
1. Sars-Cov Nucleocapsid Protein Epitopes and Uses Thereof
www.engineeringvillage.com Citation results: 500 Downloaded: 4/24/2020 1. SARS-COV NUCLEOCAPSID PROTEIN EPITOPES AND USES THEREOF KELVIN, David; PERSAD, Desmond; CAMERON, Cheryl; BRAY, Kurtis, R.; LOFARO, Lori, R.; JOHNSON, Camille; SEKALY, Rafick-Pierre; YOUNES, Souheil-Antoine; CHONG, Pele Assignee: UNIVERSITY HEALTH NETWORK; BECKMAN COULTER, INC.; UNIVERSITE DE MONTREAL; NATIONAL HEALTH RESEARCH INSTITUTES Publication Number: WO2005103259 Publication date: 11/03/2005 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 2. SARS-CoV-specific B-cell epitope and applications thereof Wu, Han-Chung; Liu, I-Ju; Chiu, Chien-Yu Assignee: National Taiwan University Publication Number: US20060062804 Publication date: 03/23/2006 Kind: Utility Patent Application Database: US Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 3. A RECOMBINANT SARS-COV VACCINE COMPRISING ATTENUATED VACCINIA VIRUS CARRIERS QIN, Chuan; WEI, Qiang; GAO, Hong; TU, Xinming; CHEN, Zhiwei; ZHANG, Linqi; HO, David, D. Assignee: INSTITUTE OF LABORATORY ANIMAL SCIENCE OF CHINESE ACADEMY OF MEDICAL SCIENCES; THE AARON DIAMOND AIDS RESEARCH CENTER; QIN, Chuan; WEI, Qiang; GAO, Hong; TU, Xinming; CHEN, Zhiwei; ZHANG, Linqi; HO, David, D. Publication Number: WO2006079290 Publication date: 08/03/2006 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data -
The Genetic Structure of SARS‐
Received: 2 September 2020 Revised: 16 October 2020 DOI: 10.1002/bies.202000240 PROBLEMS & PARADIGMS Prospects & Overviews The genetic structure of SARS-CoV-2 does not rule out a laboratory origin SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation Rossana Segreto1 Yuri Deigin2 1 Department of Microbiology, University of Innsbruck, Innsbruck, Austria Abstract 2 Youthereum Genetics Inc., Toronto, Ontario, Severe acute respiratory syndrome-coronavirus (SARS-CoV)-2′soriginisstillcontro- Canada versial. Genomic analyses show SARS-CoV-2 likely to be chimeric, most of its sequence Correspondence closest to bat CoV RaTG13, whereas its receptor binding domain (RBD) is almost iden- Rossana Segreto, Department of Microbiology, tical to that of a pangolin CoV. Chimeric viruses can arise via natural recombination or University of Innsbruck, Technikerstraße 25, 6020 Innsbruck, Austria. human intervention. The furin cleavage site in the spike protein of SARS-CoV-2 confers Email: [email protected] to the virus the ability to cross species and tissue barriers, but was previously unseen No external funding was received for this work. in other SARS-like CoVs. Might genetic manipulations have been performed in order to Rossana Segreto and Yuri Deigin contributed evaluate pangolins as possible intermediate hosts for bat-derived CoVs that were orig- equally to this study. inally unable to bind to human receptors? Both cleavage site and specific RBD could result from site-directed mutagenesis, a procedure that does not leave a trace. Consid- ering the devastating impact of SARS-CoV-2 and importance of preventing future pan- demics, researchers have a responsibility to carry out a thorough analysis of all possible SARS-CoV-2 origins. -
WHO-Convened Global Study of Origins of SARS-Cov-2: China Part
WHO-convened Global Study of Origins of SARS-CoV-2: China Part Joint WHO-China Study 14 January-10 February 2021 Joint Report 1 LIST OF ABBREVIATIONS AND ACRONYMS ARI acute respiratory illness cDNA complementary DNA China CDC Chinese Center for Disease Control and Prevention CNCB China National Center for Bioinformation CoV coronavirus Ct values cycle threshold values DDBJ DNA Database of Japan EMBL-EBI European Molecular Biology Laboratory and European Bioinformatics Institute FAO Food and Agriculture Organization of the United Nations GISAID Global Initiative on Sharing Avian Influenza Database GOARN Global Outbreak Alert and Response Network Hong Kong SAR Hong Kong Special Administrative Region Huanan market Huanan Seafood Wholesale Market IHR International Health Regulations (2005) ILI influenza-like illness INSD International Nucleotide Sequence Database MERS Middle East respiratory syndrome MRCA most recent common ancestor NAT nucleic acid testing NCBI National Center for Biotechnology Information NMDC National Microbiology Data Center NNDRS National Notifiable Disease Reporting System OIE World Organisation for Animal Health (Office international des Epizooties) PCR polymerase chain reaction PHEIC public health emergency of international concern RT-PCR real-time polymerase chain reaction SARI severe acute respiratory illness SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 SARSr-CoV-2 Severe acute respiratory syndrome coronavirus 2-related virus tMRCA time to most recent common ancestor WHO World Health Organization WIV Wuhan Institute of Virology 2 Acknowledgements WHO gratefully acknowledges the work of the joint team, including Chinese and international scientists and WHO experts who worked on the technical sections of this report, and those who worked on studies to prepare data and information for the joint mission. -
Congress of the United States
FRANK PALLONE, JR., NEW JERSEY CATHY McMORRIS RODGERS, WASHINGTON CHAIRMAN RANKING MEMBER ONE HUNDRED SEVENTEENTH CONGRESS Congress of the United States House of Representatives COMMITTEE ON ENERGY AND COMMERCE 2125 RAYBURN HOUSE OFFICE BUILDING WASHINGTON, DC 20515-6115 Majority (202) 225-2927 Minority (202) 225-3641 April 16, 2021 Mr. Peter Daszak, PhD President EcoHealth Alliance 460 West 34th Street, 17th Floor New York, NY 10001 Dear Dr. Daszak: We write to request information and documents from EcoHealth Alliance (EHA) related to the origins of SARS-CoV-2, the virus that causes COVID-19, including possible pandemic links to the Wuhan Institute of Virology (WIV).1 EHA has an extensive history with research into bat coronaviruses in China, some of which are presumed progenitors of SARS CoV-2.2 In addition, EHA has partnered with the WIV in this area of research, and WIV lists EHA as one of its eight international partners, and the only one in the U.S.3 For example, last year EHA, the WIV, and others co-authored an article on the origin and cross-species transmission of bat coronaviruses in China, and presented phylogenetic analysis suggesting a likely origin of SARS-CoV-2 in horseshoe (Rhinolophus spp.) bats.4 Further, for several years, EHA has provided some of its National Institutes of Health (NIH) federal funding to WIV as a federal sub-award recipient for bat coronavirus research to conduct high-quality testing, sequencing, field sample analyses, sample storage and 1 All references to the WIV include the former names of the Chinese establishment, that include the Wuhan Institute of Microbiology, the Wuhan Microbiology Research Laboratory, the Hubei Provincial Institute of Microbiology and the Chinese Academy of Sciences. -
NTS-Asia-Monograph-Coronavirus
Table of Contents Foreword 2 About the Authors 3 Acknowledgements 4 Introduction 5 Chapter One Pathogen Research Networks in China: Origins and Steady Development 8 Chapter Two Chinese Biosafety Level 4 Laboratories and Their Key International Linkages 21 Chapter Three Critical Assistance from Virology Networks Abroad 26 Chapter Four The Future of Chinese Virology Laboratories: China as “Number One”? 37 Appendix Graphs of Transnational Networks: China, the West and the Rest 42 Bibliography 51 NTS-Asia Monograph 1 Foreword The importance of paying close attention to health security has become more urgent than ever as the world continues to deal with the devastating impact of COVID-19 pandemic. Since its outbreak in 2020, the pandemic caused by a novel coronavirus SARS-Cov-2 has already resulted in millions of lives lost and inflicted untold human misery and suffering to people globally. The Centre for Non-Traditional Security (NTS) Studies of the S. Rajaratnam School of International Studies (RSIS), Nanyang Technological University, is one of the leading centres in Asia that highlights the critical linkages between non-traditional security challenges, like climate change and health security, to national and global security. As we have seen, the COVID-19 pandemic is more than a public health emergency of international concern. Its severe impacts cut across economic security, food security, environmental security and personal security, among others. As the international community continues to grapple with the consequential impact of COVID-19, it is sobering to note that other pandemics are expected to emerge. Thus, the need to advance the global agenda of pandemic preparedness and response cannot be overstated given the evolving nature of emerging infectious diseases. -
Searching Therapeutic Strategy of New Coronavirus Pneumonia from Angiotensin-Converting Enzyme 2: the Target of COVID-19 and SARS-Cov
European Journal of Clinical Microbiology & Infectious Diseases https://doi.org/10.1007/s10096-020-03883-y REVIEW Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV Shu-ren Li1 & Zi-jian Tang1,2 & Zai-han Li3 & Xuan Liu4 Received: 9 March 2020 /Accepted: 27 March 2020 # The Author(s) 2020 Abstract Since December 2019, the infection of the new coronavirus (COVID-19) caused an outbreak of new coronavirus pneumonia in Wuhan, China, and caused great public concern. Both COVID-19 and SARS-CoV belong to the coronavirus family and both invade target cells through ACE2. An in-depth understanding of ACE2 and a series of physiological and physiological changes caused by the virus invading the human body may help to discover and explain the corresponding clinical phenomena and then deal with them timely. In addition, ACE2 is a potential therapeutic target. This article will summarize the role of ACE2 in multiple organ damage caused by COVID-19 and SARS-CoV,targeted blocking drugs against ACE2, and drugs that inhibit inflammation in order to provide the basis for subsequent related research, diagnosis and treatment, and drug development. Keywords New coronavirus (COVID-19) . Angiotensin-converting enzyme 2 (ACE2) . SARS coronavirus (SARS-CoV) A prerequisite for coronavirus infection is its entry into host Angiotensin-converting enzyme 2 (ACE2) cells. In this process, spike protein (S protein) recognizes host cell receptors and induces fusion of viral and cell membranes. Renin-angiotensin system (RAS) is an important neuroendo- XU et al. [1] found that the S protein of COVID-19 is similar crine system in the human body, it including the classical to the S protein of SARS coronavirus (SARS-CoV) through angiotensin converting enzyme (ACE) -angiotensin II biological analysis. -
Mink and SARS-Cov-2
Mink farming & SARS-CoV-2 Mink farming & SARS-CoV-2 Center for a Humane Economy & Animal Wellness Action June 2021 Center for a Humane Economy P.O. Box 30845 Bethesda MD 20824 https://centerforahumaneeconomy.org/ Animal Wellness Action 611 Pennsylvania Avenue, S.E. #136 Washington DC 20003 https://animalwellnessaction.org/ Copyright © 2021 by the Center for a Humane Economy and Animal Wellness Action. All rights reserved. 1 Mink farming & SARS-CoV-2 Table of Contents Page(s) Review and analysis ....................................................................................... 6-11 I - Executive summary .............................................................................................................................. 6 II - Underlying risk factors posed by captive mink on farms ................................................................. 6 III - Key findings ....................................................................................................................................... 6 IV - Key policy conclusions and recommendations .................................................................................8 V - Methodology ........................................................................................................................................ 9 Authorship ................................................................................................................................................ 9 Acknowledgments .................................................................................................................................... -
Most Attacks on PCR Tests Are Narrowly Focused on Technicalities, As If It Takes One Lucky Punch to Take out Drosten and with Him Knock out the Entire Pandemic
Most attacks on PCR tests are narrowly focused on technicalities, as if it takes one lucky punch to take out Drosten and with him knock out the entire pandemic. That's not only simplistic, but dangerous. Drosten is a tool. He did not concoct any of this, he is just executing what is being asked of him. Apparently someone convinced him that the West is done, and that he should try and save his own skin, and that of his partner and young child. I'm aware that many researchers, journalists and critics on our side have chosen to discard any and all conspiracy theories, as they call them. For the better part of 2020 they have chosen to attribute all of what's happening to incompetence, but when this position was no longer tenable they switched to attributing everything to coincidence. Hence the term "coincidence theorist": A person who believes that everything happens by sheer coincidence, there's no such thing as corruption, deceit or back room deals & mankind just "got over" the desire for world domination. But let's leave aside obvious coincidence candidates such as Event 201, and let's have a look how the pandemic actually started. More specifically, who started it, and when. Klaus Schwab is not a creative mind. The reason why most of his 4IR plot sounds crazy is because he just copy'n'pasted it from various sources he deemed hip and current at the time. A bit like an old fart trying to stay relevant by mimicking, in a very embarrassing way, what he perceives as being modern without understanding what it actually is, eg. -
Infection, Genetics and Evolution 84 (2020) 104384
Infection, Genetics and Evolution 84 (2020) 104384 Contents lists available at ScienceDirect Infection, Genetics and Evolution journal homepage: www.elsevier.com/locate/meegid Review SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective T Manuela Sironia, Seyed E. Hasnainb, Benjamin Rosenthalj, Tung Phanc, Fabio Lucianid, Marie-Anne Shawe, M. Anice Sallumf, Marzieh Ezzaty Mirhashemig, Serge Morandh, ⁎ Fernando González-Candelasi, , on behalf of the Editors of Infection, Genetics and Evolution a Bioinformatics Unit, Scientific Institute IRCCS E. MEDEA, Bosisio Parini (LC), Italy b JH Institute of Molecular Medicine, Jamia Hamdard, Tughlakabad, New Delhi, India c Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA d University of New South Wales, Sydney, 2052, New South Wales, Australia e Leeds Institute of Medical Research at St James's, School of Medicine, University of Leeds, Leeds, United Kingdom f Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil g University of Massachusetts Medical School, Worcester, MA 01655-0112, USA h Institute of Evolution Science of Montpellier, Case Courier 064, F-34095 Montpellier, France i Joint Research Unit Infection and Public Health FISABIO-University of Valencia, Institute for Integrative Systems Biology (I2SysBio) and CIBER in Epidemiology and Public Health, Valencia, Spain j Animal Parasitic Disease Laboratory, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD, USA ARTICLE INFO ABSTRACT Keywords: In less than five months, COVID-19 has spread from a small focus in Wuhan, China, to more than 5 million Coronavirus people in almost every country in the world, dominating the concern of most governments and public health Coevolution systems. -
The Latest News Around Us 5 30 2021 CEO Pay Rises To
The latest News Around Us_5_30_2021 CEO pay rises to $12.7M even as pandemic ravages economy STAN CHOE - AP Business Provided by Associated PressFILE- This photo combo shows from left, Brian Niccol, CEO of Chipotle, Advance Auto Parts CEO Tom Greco, Carnival Corp. CEO Arnold Donald. Pay packages rose yet again in 2020 for the CEOs of the biggest U.S. companies, even though the pandemic sent the economy to its worst quarter on record and slashed corporate profits around the world. (AP Photo/File) NEW YORK (AP) — As COVID-19 ravaged the world last year, CEOs’ big pay packages seemed to be under as much threat as everything else. Fortunately for those CEOs, many had boards of directors willing to see the pandemic as an extraordinary event beyond their control. Across the country, boards made changes to the intricate formulas that determine their CEOs’ pay — and other moves — that helped make up for losses created by the crisis. As a result, pay packages rose yet again last year for the CEOs of the biggest companies, even though the pandemic sent the economy to its worst quarter on record and slashed corporate profits around the world. The median pay package for a CEO at an S&P 500 company hit $12.7 million in 2020, according to data analyzed by Equilar for The Associated Press. That means half the CEOs in the survey made more, and half made less. It’s 5% more than the median pay for that same group of CEOs in 2019 and an acceleration from the 4.1% climb in last year’s survey. -
Havanareporter YEAR VI
THE © YEAR VI Nº 8 APR, 20 2017 HAVANA, CUBA avana eporter ISSN 2224-5707 YOUR SOURCE OF NEWS & MORE H R Price: A Bimonthly Newspaper of the Prensa Latina News Agency 1.00 CUC, 1.00 USD, 1.20 CAN P. 3 Sustainable Solutions to Drought in Cuba P. 14 Cuba Health & Culture Politics UNIDF Seeks Funds Science Buena Fe Progressive for Projects Cubagua 2017: All Beat Moreno Wins in Cuba about Water the Odds Ecuadorian P.3 P. 5 P. 10 Presidency P. 14 2 Cosmetic Surgery Program Cuba features a national surgery network and access to minimum access technique, so it’s ranked among the most outstanding countries in these procedures in the region. With 119 service facilities distributed throughout the national territory, this network undergoes a permanent revitalization and modernization process aimed at developing each of the surgical specialties, as part of a policy to foster minimum access techniques on the Island. Cuba offers attractive options in this field, not only targeting beauty and self-satisfaction based on beauty patterns, but as ways to fix physical problems or psychological disorders as a result of the volume and body shape. The experience gathered by the country’s medical staffs, seriousness in these practices and postoperative processes that combine recovery and vacation programs on the Island, stand out as an excellent alternative. www.smcsalud.cu CUBA 3 Victory for Socialism at “Bay of Pigs” By ErnestoVERA It only took three days and two nights to thwart the Combat commenced in earnest the following day mercenary invasion at Giron Beach in 1961, until then and concluded on April 19 with the first great defeat of the White House and CIA’s most serious endeavor to U.S.