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Radiotherapy for Unresectable Locally Advanced Non-Small Cell Lung Cancer
2112 Review Article Radiotherapy for unresectable locally advanced non-small cell lung cancer: a narrative review of the current landscape and future prospects in the era of immunotherapy Tiantian Guo1,2#, Liqing Zou1,2#, Jianjiao Ni1,2, Xiao Chu1,2, Zhengfei Zhu1,2,3 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; 2Department of Oncology, Shanghai Medical College, 3Institute of Thoracic Oncology, Fudan University, Shanghai, China Contributions: (I) Conception and design: Z Zhu; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. #These two authors contributed equally to this work. Correspondence to: Zhengfei Zhu, MD. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032 China. Email: [email protected]. Abstract: Significant recent advances have occurred in the use of radiation therapy for locally advanced non-small cell lung cancer (LA-NSCLC). In fact, the past few decades have seen both therapeutic gains and setbacks in the evolution of radiotherapy for LA-NSCLC. The PACIFIC trial has heralded a new era of immunotherapy and has raised important questions for future study, such as the future directions of radiation therapy for LA-NSCLC in the era of immunotherapy. Modern radiotherapy techniques such as three-dimensional (3D) conformal radiotherapy and intensity-modulated radiotherapy (IMRT) provide opportunities for improved target conformity and reduced normal-tissue exposure. However, the low-dose radiation volume brought by IMRT and its effects on the immune system deserve particular attention when combing radiotherapy and immunotherapy. -
Role of Endolysosomes and Inter-Organellar Signaling in Brain Disease
University of North Dakota UND Scholarly Commons Biomedical Sciences Faculty Publications Department of Biomedical Sciences 2-2020 Role of endolysosomes and inter-organellar signaling in brain disease Zahra Afghah Xuesong Chen University of North Dakota, [email protected] Jonathan David Geiger University of North Dakota, [email protected] Follow this and additional works at: https://commons.und.edu/bms-fac Part of the Medicine and Health Sciences Commons Recommended Citation Afghah, Zahra; Chen, Xuesong; and Geiger, Jonathan David, "Role of endolysosomes and inter-organellar signaling in brain disease" (2020). Biomedical Sciences Faculty Publications. 1. https://commons.und.edu/bms-fac/1 This Article is brought to you for free and open access by the Department of Biomedical Sciences at UND Scholarly Commons. It has been accepted for inclusion in Biomedical Sciences Faculty Publications by an authorized administrator of UND Scholarly Commons. For more information, please contact [email protected]. Neurobiology of Disease 134 (2020) 104670 Contents lists available at ScienceDirect Neurobiology of Disease journal homepage: www.elsevier.com/locate/ynbdi Review Role of endolysosomes and inter-organellar signaling in brain disease T ⁎ Zahra Afghah, Xuesong Chen, Jonathan D. Geiger Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58201, United States of America ARTICLE INFO ABSTRACT Keywords: Endosomes and lysosomes (endolysosomes) are membrane bounded organelles that play a key role in cell sur- Endolysosomes vival and cell death. These acidic intracellular organelles are the principal sites for intracellular hydrolytic Mitochondria activity required for the maintenance of cellular homeostasis. -
Office of Fiscal & Monitoring Services Bureau of County Finance And
Office of Fiscal & Monitoring Services Bureau of County Finance and Technical Assistance County Points of Contact for BCFTA Help Desk REGION 1 COUNTY SERVICE LOCATION LAST NAME FIRST NAME E‐MAIL CONTACT Champaign LAA11, LAC11, LAP11 Bacon Martha [email protected] Stewart Holly [email protected] LAC21 Bowens Joyce [email protected] Delaware Gray Adeana [email protected] LAA21, LAP21 Schonauer Jacqueline [email protected] Walters Jacqueline [email protected] Fairfield LAA23, LAC23, LAP23 Brown Carri [email protected] McCoy Amy [email protected] Fayette LAA24, LAC24, LAP24 Cave Abby [email protected] Williamson Faye [email protected] Franklin LAC25 Jittkarunrat Sirina [email protected] Okafor Emeka [email protected] Knox LAA42, LAC42, LAP42 Feltman Andrea [email protected] Myers Jacqueline [email protected] LAC45 Bryan Cynthia [email protected] Licking LAA45, LAP45 Mitchell Erica [email protected] Spangler Jamie [email protected] LAA46, LAC46 Fay Sandra [email protected] Logan Fogle Cheryl [email protected] LAP46 Nease Shoan [email protected] Pugh Kathy [email protected] Madison LAA49, LAC49, LAP49 Kaifas Steve [email protected] Vickers Donna [email protected] LAA51, LAC51 Chapman Melissa [email protected] Marion Harless Julie [email protected] LAP51 Downes Patrick [email protected] Spencer Becky [email protected] Morrow LAA59, LAC59, LAP59 Keeran -
Babies' First Forenames: Births Registered in Scotland in 2007
Babies' first forenames: births registered in Scotland in 2007 Information about the basis of the list can be found via the 'Babies' First Names' page on the National Records of Scotland website. Boys Girls Position Name Number of babies Position Name Number of babies 1 Lewis 735 1 Sophie 653 2 Jack 726 2 Emma 508 3 Ryan 517 3 Lucy 438 4 James 489 4 Katie 435 5 Callum 441 5 Ellie 415 6 Cameron 428 6 Erin 414 7 Daniel 424 7 Emily 407 8 Liam 406 8 Amy 405 9 Matthew 386 9 Chloe 387 10 Jamie 385 10 Olivia 386 11 Logan 374 11 Hannah 371 12 Finlay 370 12 Jessica 318 13 Kyle 369 13 Grace 300 14 Adam 355 14 Ava 282 15 Alexander 322 15 Rebecca 274 16 Andrew 311 16 Isla 249 17 Aiden 309 17 Brooke 234 18 Ben 308 18 Eva 227 19 Connor 307 19 Niamh 220 20 Dylan 305 20 Megan 215 21 Aaron 300 21 Eilidh 213 22 Thomas 290 22= Abbie 206 23 Joshua 260 22= Mia 206 24 David 251 24 Aimee 201 25 Luke 243 25= Lauren 199 26 Nathan 232 25= Ruby 199 27 Ross 231 27 Skye 198 28 Charlie 219 28= Anna 197 29 Aidan 214 28= Holly 197 30 Ethan 212 30= Freya 196 31 John 210 30= Rachel 196 32 Michael 205 32= Caitlin 190 33 Samuel 202 32= Sarah 190 34 Calum 199 34= Keira 183 35= Kieran 197 34= Leah 183 35= Scott 197 36 Lily 180 37 Fraser 196 37 Millie 167 38= Josh 191 38 Charlotte 162 38= William 191 39 Molly 159 40 Oliver 185 40= Abigail 157 41 Rhys 183 40= Zoe 157 42 Harry 178 42 Eve 156 43 Sean 177 43 Kayla 154 44= Owen 175 44 Iona 144 44= Sam 175 45 Cara 137 46= Christopher 173 46 Ella 136 46= Robert 173 47 Evie 122 48 Euan 169 48 Nicole 117 49= Jake 164 49 Morgan 114 49= -
Primitivo B Felias
PRIMITIVO B. FELIAS III Address:348-D Chico St.,Cembo Makati City Mobile number: 09215341851 [email protected] Objective: A position in the art/design department where my skills can be utilize in accomplishing tasks and solving problems. To be in a company that will help me grow as a person and an employee, to provide quality service and share my skills and knowledge to colleagues, and learn from them as well, for the betterment of the team and the company. Skills Computer Literate (Adobe Illustrator, Adobe Photoshop, Adobe Premiere, Adobe After Effects, Adobe Audition, Adobe Flash, MS Powerpoint, Blender 3D software, Garage Band, Bryce 3D software, MakeHuman 3D, 3D Studio Max, Microsoft Movie Maker, Realflow 3D, Sculptris 3D, Mixcraft 5) Digital Video Editing, 3D Modeling and Basic Animation, Sound Editing, Digital and Manual Photography, Graphics Design and Illustration, Motion Graphics Design/Compositing, Flash-Base Web Design, GUI Design, Photo Manipulation, Basic Action Scripting, Flash Animation, Theater Actor, Singer, Dancer and can work with minimal supervision. Online Portfolio http://primefelias.daportfolio.com/ Online DemoReel http://www.youtube.com/watch?v=GBh5w-UGld8 Educational Background College: University of the Philippines Bachelor of Fine Arts major in Visual Communications Year Graduated: 2008 Secondary: Araullo High School Year Graduated:2004 Elementary: Nasipit Central Elementary School, Agusan del Norte Year Graduated: 2000 Work-Related Experiences DATE COMPANY POSITION May 23, 2011-present Holy Cow! Animation AFX Compositor/Digital Artist March 30, 2011- July 2011 Buko Graphics Studios Freelance 3D Concept Artist March 21, 2011 – May 11, 2011 BigFish International Inc. (Motion)Graphic Artist Unit 1804 Jollibee Plaza, Emerald Ave., Ortigas Sept. -
Proton Stereotactic Body Radiation Therapy for Liver Metastases— Results of 5-Year Experience for 81 Hepatic Lesions
1760 Original Article Proton stereotactic body radiation therapy for liver metastases— results of 5-year experience for 81 hepatic lesions Alex R. Coffman1, Daniel C. Sufficool2, Joseph I. Kang1, Chung-Tsen Hsueh3, Sasha Swenson4, Patrick Q. McGee4, Gayathri Nagaraj3, Baldev Patyal1, Mark E. Reeves5, Jerry D. Slater1, Gary Y. Yang1 1Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA; 2Department of Radiation Oncology, Kettering Health Network, Kettering, OH, USA; 3Department of Medical Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA; 4Loma Linda University School of Medicine, Loma Linda, CA, USA; 5Department of Surgical Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA Contributions: (I) Conception and design: GY Yang; (II) Administrative support: B Patyal, JD Slater, GY Yang; (III) Provision of study materials or patients: CT Hsueh, G Nagaraj, ME Reeves; (IV) Collection and assembly of data: AR Coffman, GY Yang; (V) Data analysis and interpretation: AR Coffman, GY Yang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Alex R. Coffman, MD. Department of Radiation Oncology, Loma Linda University Medical Center, 11234 Anderson Street, Suite B121, Loma Linda, CA 92354, USA. Email: [email protected]. Background: To report on our institutional experience using Proton stereotactic body radiation therapy (SBRT) for patients with liver metastases. Methods: All patients with liver metastases treated with Proton SBRT between September 2012 and December 2017 were retrospectively analyzed. Local control (LC) and overall survival (OS) were estimated using the Kaplan-Meier method calculated from the time of completion of Proton SBRT. LC was defined according to Response Evaluation Criteria in Solid Tumors (RECIST) guidelines (version 1.1). -
An Analysis of Vertebral Body Growth After Proton Beam Therapy for Pediatric Cancer
cancers Article An Analysis of Vertebral Body Growth after Proton Beam Therapy for Pediatric Cancer Keiichiro Baba 1, Masashi Mizumoto 1,* , Yoshiko Oshiro 1,2, Shosei Shimizu 1 , Masatoshi Nakamura 1, Yuichi Hiroshima 1 , Takashi Iizumi 1, Takashi Saito 1, Haruko Numajiri 1, Kei Nakai 1 , Hitoshi Ishikawa 1,3, Toshiyuki Okumura 1, Kazushi Maruo 4 and Hideyuki Sakurai 1 1 Proton Medical Research Center, Department of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, Ibaraki 305-8576, Japan; [email protected] (K.B.); [email protected] (Y.O.); [email protected] (S.S.); [email protected] (M.N.); [email protected] (Y.H.); [email protected] (T.I.); [email protected] (T.S.); [email protected] (H.N.); [email protected] (K.N.); [email protected] (H.I.); [email protected] (T.O.); [email protected] (H.S.) 2 Department of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki 305-8558, Japan 3 National Institutes for Quantum and Radiological Science and Technology, QST Hospital, Chiba 263-8555, Japan 4 Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; [email protected] * Correspondence: [email protected]; Tel.: +81-29-853-7100; Fax: +81-29-853-7102 Simple Summary: Radiotherapy has a key role in treatment of pediatric cancer and has greatly improved survival in recent years. However, vertebrae are often included in the irradiated area, and this may affect growth after treatment. -
Perspectives from Hazards, Disaster, and Emergency Management
CARRI Research Report 1 COMMUNITY AND REGIONAL RESILIENCE: PERSPECTIVES FROM HAZARDS, DISASTERS, AND EMERGENCY MANAGEMENT Susan L. Cutter,* Lindsey Barnes, Melissa Berry, Christopher Burton, Elijah Evans, Eric Tate, and Jennifer Webb Hazards and Vulnerability Research Institute Department of Geography University of South Carolina Columbia, South Carolina *Carolina Distinguished Professor and Director of the Hazards and Vulnerability Research Institute Date Published: September 2008 Community and Regional Resilience Initiative RESEARCH FINDINGS ABOUT COMMUNITY AND REGIONAL RESILIENCE One of the commitments of the Community and Regional Resilience Initiative (CARRI) is to understand what resilience is and how to get there, based on research evidence. As one resource for this effort, CARRI has commissioned a number of summaries of existing knowledge about resilience, arising from a number of different research traditions. This paper is one in a series of such summaries, which will be integrated with new resilience explorations in several CARRI partner cities and with further discussions with the research community and other stakeholders to serve as the knowledge base for the initiative. For further information about CARRI’s research component, contact Thomas J. Wilbanks, [email protected], or Sherry B. Wright, [email protected]. CARRI Research Report 1 iii Community and Regional Resilience Initiative COMMUNITY AND REGIONAL RESILIENCE INITIATIVE Oak Ridge National Laboratory’s (ORNL) Community and Regional Resilience Initiative (CARRI) -
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Particle Accelerators and Detectors for Medical Diagnostics and Therapy Arxiv:1601.06820V1 [Physics.Med-Ph] 25 Jan 2016
Particle Accelerators and Detectors for medical Diagnostics and Therapy Habilitationsschrift zur Erlangung der Venia docendi an der Philosophisch-naturwissenschaftlichen Fakult¨at der Universit¨atBern arXiv:1601.06820v1 [physics.med-ph] 25 Jan 2016 vorgelegt von Dr. Saverio Braccini Laboratorium f¨urHochenenergiephysik L'aspetto pi`uentusiasmante della scienza `eche essa incoraggia l'uomo a insistere nei suoi sogni. Guglielmo Marconi Preface This Habilitation is based on selected publications, which represent my major sci- entific contributions as an experimental physicist to the field of particle accelerators and detectors applied to medical diagnostics and therapy. They are reprinted in Part II of this work to be considered for the Habilitation and they cover original achievements and relevant aspects for the present and future of medical applications of particle physics. The text reported in Part I is aimed at putting my scientific work into its con- text and perspective, to comment on recent developments and, in particular, on my contributions to the advances in accelerators and detectors for cancer hadrontherapy and for the production of radioisotopes. Dr. Saverio Braccini Bern, 25.4.2013 i ii Contents Introduction 1 I 5 1 Particle Accelerators and Detectors applied to Medicine 7 2 Particle Accelerators for medical Diagnostics and Therapy 23 2.1 Linacs and Cyclinacs for Hadrontherapy . 23 2.2 The new Bern Cyclotron Laboratory and its Research Beam Line . 39 3 Particle Detectors for medical Applications of Ion Beams 49 3.1 Segmented Ionization Chambers for Beam Monitoring in Hadrontherapy 49 3.2 Proton Radiography with nuclear Emulsion Films . 62 3.3 A Beam Monitor Detector based on doped Silica Fibres . -
Medical Physics</I>
Anniversary Paper: Development of x-ray computed tomography: The role of Medical Physics and AAPM from the 1970s to present ͒ Xiaochuan Pana Department of Radiology, University of Chicago, Chicago, Illinois 60637 Jeffrey Siewerdsen Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario M5G 2M9, Canada and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada Patrick J. La Riviere Department of Radiology, University of Chicago, Chicago, Illinois 60637 Willi A. Kalender Institute of Medical Physics, University Erlangen-Nuernberg, 91052 Erlangen, Germany ͑Received 7 April 2008; revised 9 June 2008; accepted for publication 9 June 2008; published 22 July 2008͒ The AAPM, through its members, meetings, and its flagship journal Medical Physics, has played an important role in the development and growth of x-ray tomography in the last 50 years. From a spate of early articles in the 1970s characterizing the first commercial computed tomography ͑CT͒ scanners through the “slice wars” of the 1990s and 2000s, the history of CT and related techniques such as tomosynthesis can readily be traced through the pages of Medical Physics and the annals of the AAPM and RSNA/AAPM Annual Meetings. In this article, the authors intend to give a brief review of the role of Medical Physics and the AAPM in CT and tomosynthesis imaging over the last few decades. © 2008 American Association of Physicists in Medicine. ͓DOI: 10.1118/1.2952653͔ Key words: computed tomography, tomosynthesis I. INTRODUCTION duction of CT in 1972 by EMI, and then trailing off through the 1980s as the technology matured and emerging technolo- As the AAPM celebrates its 50th anniversary, it is natural to gies, such as magnetic resonance imaging ͑MRI͒, won atten- pause and take stock of the contribution its members, meet- tion from researchers and clinicians alike. -
Influence of Pathogenic Bacterial Determinants on Genome
INFLUENCE OF PATHOGENIC BACTERIAL DETERMINANTS ON GENOME STABILITY OF EXPOSED INTESTINAL CELLS AND OF DISTAL LIVER AND SPLEEN CELLS Paul S. Walz B.Sc. Hons., University of Western Ontario, 2009 A Thesis Submitted to the School of Graduate Studies of the University of Lethbridge in Partial Fulfillment of the Requirements for the Degree MASTERS OF SCIENCE Department of Biology University of Lethbridge LETHBRIDGE, ALBERTA, CANADA © Paul S. Walz, 2011 INFLUENCE OF PATHOGENIC BACTERIAL DETERMINANTS ON GENOME STABILITY OF EXPOSED INTESTINAL CELLS AND OF DISTAL LIVER AND SPLEEN CELLS Paul S. Walz Approved Dr. Igor Kovalchuk, Co-Supervisor, Department of Biological Science, MD, PhD Date Dr. Olga Kovalchuk, Co-Supervisor, Department of Biological Science, MD, PhD Date Dr. Brent Selinger, Thesis Committee Member, Department of Biological Science, PhD Date Dr. James Thomas, Thesis Committee Member, Department of Biological Science, PhD Date Dr. Lesley Brown, Thesis Committee Member, Department of Kinesiology & Phys. Ed., PhD Date Dr. Elizabeth Schultz/Dr. Theresa Burg, Chair, Department of Biological Science, PhD Date ABSTRACT Most bacterial infections can be correlated to contamination of consumables such as food and water. Upon contamination, boil water advisories have been ordered to ensure water is safe to consume, despite the evidence that heat-killed bacteria can induce genomic instability of exposed (intestine) and distal cells (liver and spleen). We hypothesize that exposure to components of heat-killed Escherichia coli O157:H7 will induce genomic instability within animal cells directly and indirectly exposed to these determinants. Mice were exposed to various components of dead bacteria such as DNA, RNA, protein or LPS as well as to whole heat-killed bacteria via drinking water. -
2013 Kaiser Permanente-Authored Publications Alphabetical by Author
2013 Kaiser Permanente-Authored Publications Alphabetical by Author 1. Abbas MA, Cannom RR, Chiu VY, Burchette RJ, Radner GW, Haigh PI, Etzioni DA Triage of patients with acute diverticulitis: are some inpatients candidates for outpatient treatment? Colorectal Dis. 2013 Apr;15(4):451-7. Southern California 23061533 KP author(s): Abbas, Maher A; Chiu, Vicki Y; Burchette, Raoul J; Radner, Gary W; Haigh, Philip I 2. Abbass MA, Slezak JM, DiFronzo LA Predictors of Early Postoperative Outcomes in 375 Consecutive Hepatectomies: A Single- institution Experience Am Surg. 2013 Oct;79(10):961-7. Southern California 24160779 KP author(s): Abbass, Mohammad Ali; Slezak, Jeffrey M; DiFronzo, Andrew L 3. Abbenhardt C, Poole EM, Kulmacz RJ, Xiao L, Curtin K, Galbraith RL, Duggan D, Hsu L, Makar KW, Caan BJ, Koepl L, Owen RW, Scherer D, Carlson CS, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and CCFR, Potter JD, Slattery ML, Ulrich CM Phospholipase A2G1B polymorphisms and risk of colorectal neoplasia Int J Mol Epidemiol Genet. 2013 Sep 12;4(3):140-9. Northern California 24046806 KP author(s): Caan, Bette 4. Aberg JA, Gallant JE, Ghanem KG, Emmanuel P, Zingman BS, Horberg MA Primary Care Guidelines for the Management of Persons Infected With HIV: 2013 Update by the HIV Medicine Association of the Infectious Diseases Society of America Clin Infect Dis. 2013 Nov 13. Mid-Atlantic 24235263 KP author(s): Horberg, Michael 5. Abraham AG, D'Souza G, Jing Y, Gange SJ, Sterling TR, Silverberg MJ, Saag MS, Rourke SB, Rachlis A, Napravnik S, Moore RD, Klein MB, Kitahata MM, Kirk GD, Hogg RS, Hessol NA, Goedert JJ, Gill MJ, Gebo KA, Eron JJ, Engels EA, Dubrow R, Crane HM, Brooks JT, Bosch RJ, Strickler HD, North American AIDS Cohort Collaboration on Research and Design of IeDEA Invasive cervical cancer risk among HIV-infected women: A North American multi-cohort collaboration prospective study J Acquir Immune Defic Syndr.