Real-Life Effectiveness and Safety of Glecaprevir/Pibrentasvir for Korean Patients with Chronic Hepatitis C at a Single Institution
Gut and Liver https://doi.org/10.5009/gnl19393 pISSN 1976-2283 eISSN 2005-1212 Original Article Real-Life Effectiveness and Safety of Glecaprevir/Pibrentasvir for Korean Patients with Chronic Hepatitis C at a Single Institution Young Joo Park1,2, Hyun Young Woo1,2, Jeong Heo1,2, Sang Gyu Park3, Young Mi Hong1,4, Ki Tae Yoon1,4, Dong Uk Kim1,2, Gwang Ha Kim1,2, Hyung Hoi Kim2,5, Geun Am Song1,2, and Mong Cho1,4 1Department of Internal Medicine, College of Medicine, Pusan National University, 2Biomedical Research Institute, Pusan National University Hospital, 3Department of Internal Medicine, Good Samsun Hospital, Busan, 4Liver Center, Pusan National University Yangsan Hospital, Yangsan, and 5Department of Laboratory Medicine, College of Medicine, Pusan National University, Busan, Korea Article Info Background/Aims: Glecaprevir/pibrentasvir (G/P) is a combination of direct-acting antiviral Received November 21, 2019 agents that is an approved treatment for chronic infections by all six hepatitis C virus (HCV) geno- Revised June 3, 2020 types. However, there are limited data on the effect of G/P in Korean patients in actual real-world Accepted June 21, 2020 settings. We evaluated the real-life effectiveness and safety of G/P at a single institution in Korea. Published online August 26, 2020 Methods: This retrospective, observational, cohort study used sustained virologic response at 12 weeks after treatment completion (SVR12) as the primary effectiveness endpoint. Safety and Corresponding Author tolerability were also determined. Jeong Heo Results: We examined 267 individuals who received G/P for chronic HCV infections. There were ORCID https://orcid.org/0000-0003-0961-7851 148 females (55.4%), and the overall median age was 63.0 years (range, 25 to 87 years).
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