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Extra-Intestinal Manifestations of Inflammatory Bowel Disease
Open Access Review Article DOI: 10.7759/cureus.17187 Extra-Intestinal Manifestations of Inflammatory Bowel Disease Aliya H. Sange 1 , Natasha Srinivas 2 , Mubashira K. Sarnaik 3 , Srimy Modi 1 , Yasaswi Pisipati 4 , Sarayoo Vaidya 3 , Naqvi Syed Gaggatur 3 , Ibrahim Sange 5, 6 1. Research, K.J. Somaiya Medical College, Mumbai, IND 2. Research, BGS Global Institute of Medical Sciences, Bangalore, IND 3. Internal Medicine, M.S. Ramaiah Medical College, Bangalore, IND 4. Psychiatry, M.S. Ramaiah Medical College, Bangalore, IND 5. Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA 6. Medicine, K.J. Somaiya Medical College, Mumbai, IND Corresponding author: Aliya H. Sange, [email protected] Abstract Inflammatory bowel disease (IBD) is associated with extra-intestinal manifestations (EIMs) that tend to parallel intestinal activity and have a debilitating effect on the quality of life. EIMs primarily affect the joints, skin, and eyes with less frequent involvement of the liver, kidney, and pancreas. This article reviews the prevalence of musculoskeletal, dermatological, ocular, and other manifestations in IBD and their coalition with underlying intestinal inflammation. EIMs occurring independently of intestinal activity are managed by targeted therapies, categorical regimens, and specific treatments. On the other hand, EIMs paralleling the bowel activity are carefully monitored while the IBD is brought under control. Since the etiology of the disease is responsible for the development of the EIMs, the research scrutinizes the identified pathogenic mechanisms that tend to involve genetic susceptibility, aberrant self-recognition, and autoantibodies directed against organ-specific antigens shared by intestinal and extra-intestinal organs. This article also provides an overview of the epidemiology, clinical features, diagnostic modalities, and management of the EIMs associated with IBD. -
History Lectured on Midwifery at St Bartholomew’S Hospital and and Was in Attendance at the Births of All of Her Children
J R Coll Physicians Edinb 2012; 42:274–9 Paper http://dx.doi.org/10.4997/JRCPE.2012.317 © 2012 Royal College of Physicians of Edinburgh Sir Charles Locock and potassium bromide MJ Eadie Honorary Research Consultant and Emeritus Professor, Faculty of Health Sciences, University of Queensland, Royal Brisbane and Women’s Hospital, Australia ABSTRACT On 12 May 1857, Edward Sieveking read a paper on epilepsy to the Correspondence to M Eadie Royal Medical and Chirurgical Society in London. During the discussion that Faculty of Health Sciences, followed Sir Charles Locock, obstetrician to Queen Victoria, was reported to have University of Queensland, Royal Brisbane and Women’s commented that during the past 14 months he had used potassium bromide to Hospital, Herston, successfully stop epileptic seizures in all but one of 14 or 15 women with ‘hysterical’ Brisbane 4029, Australia or catamenial epilepsy. This report of Locock’s comment has generally given him credit for introducing the first reasonably effective antiepileptic drug into medical Tel 61 2 (0)7 38311704 e-mail [email protected] practice. However examination of the original reports raises questions as to how soundly based the accounts of Locock’s comments were. Subsequently, others using the drug to treat epilepsy failed to obtain the degree of benefit that the reports of Locock’s comments would have led them to expect. The drug might not have come into more widespread use as a result, had not Samuel Wilks provided good, independent evidence for the drug’s antiepileptic efficacy in 1861. KEYWORDS Epilepsy treatment, Charles Locock, potassium bromide, Edward Sieveking, Samuel Wilks DECLaratIONS OF INTERESTS No conflicts of interest declared. -
Editorial Ulcerative Colitis: the Scope of the Scopes in Nomenclature and Diagnosis
Tropical Gastroenterology 2011;32(2):87–93 Editorial Ulcerative Colitis: The scope of the scopes in nomenclature and diagnosis S. Datta Gupta Department of Pathology Life-long learning is the hall-mark of professional education. This is often the result of All India Institute of Medical Sciences experiences shared by our colleagues world-wide, of common clinical conditions that present New Delhi - 110029, India in an unusual manner. Correspondence: The two major constituents of inflammatory bowel disease: Crohn’s disease (CD) and Dr. S. Datta Gupta ulcerative colitis (UC) have several overlapping features and their distinction in difficult Email: [email protected] cases is a true accreditation of the skills of a gastroenterologist. Indistinguishable cases are aptly labeled as indeterminate colitis. In certain countries such as India, additionally, colonic tuberculosis (TB) is a close differential of colonic Crohn’s disease mainly because both are recognized to show patchy involvement and granulomatous inflammation. In this issue of the journal, Shah SN, Amarapurkar AD, Thiruvengadam NR, Nistala S and Rathi PM1 highlight unusual presentations of ulcerative colitis that may make the diagnosis otherwise difficult. Non-contagious diarrheal diseases have been apparent to physicians over centuries having been described by Aretaeus (A.D. 300) and Soranus (A.D. 117).2 Sir Samuel Wilks in 18593 has been credited with introducing the term “ulcerative colitis” to a disease that was less understood then and perhaps even lesser understood today. It is likely that several clinically similar diseases may have been considered under this term. Thus it has been suggested that in 1745 Prince Charles, the Young Pretender to the throne, cured himself of ulcerative colitis by adopting a milk-free diet!2,4 Excellent descriptions have been provided by the Surgeon General of the Union Army (describing the medical history of the American Civil War), Wilks & Moxon (1875), Allchin (1885) and Hale-White (1888). -
Dr More, Having Been Accused of Irregular Practice by the College Of
APPENDIX 1 Dr John More and the College of Physicians Dr More, having been accused of irregular practice by the College of Physicians (CPh) in 1612, was the next year charged with an offence against good taste in criticising the practice of Dr Francis Herring, a fellow of the College (FCP), and Archbishop Abbot took the opportunity to ban More from practising. The College was short of funds, however, and in 1617 the considerable sum of £20, a 'voluntary deposit' from More, induced the President, Henry Atkins, to propose conditional acceptance 'until either the King or [Privy] Councillors prohibit it'. This met with substantial resistance - More's formal admission was turned down by the Fellowship on a 15/5 vote. Even so, when Dr Arthur Dee, son of the celebrated Dr John Dee and a physician to Queen Anne, was asked by the CPh by what authority he presumed to practise, Dee replied in exasperation that 'medicine was his profession and that as he could make a business out of it, he ought to follow it', and cited More and Thomas Turner as examples of irregulars whose activities were being condoned by the College. i More continued to press the £20 offer - substantial compared to fees being paid at the time - ii and Atkins pointed out that, despite the embarrassment of Abbot's ban, his licensing 'would be pleasing to important men'. After further wrangling, in March 1619 the Fellows narrowly voted him in, and William Munk lists him as a licentiate of the College. iii Even so, 'the Registrar was careful to inscribe in full his letter averring the money to be a free gift, and More himself “ever...a servante” of the College'. -
Slater V. Baker and Stapleton (C.B. 1767): Unpublished Monographs by Robert D. Miller
SLATER V. BAKER AND STAPLETON (C.B. 1767): UNPUBLISHED MONOGRAPHS BY ROBERT D. MILLER ROBERT D. MILLER, J.D., M.S. HYG. HONORARY FELLOW MEDICAL HISTORY AND BIOETHICS DEPARTMENT SCHOOL OF MEDICINE AND PUBLIC HEALTH UNIVERSITY OF WISCONSIN - MADISON PRINTED BY AUTHOR MADISON, WISCONSIN 2019 © ROBERT DESLE MILLER 2019 BOUND BY GRIMM BOOK BINDERY, MONONA, WI AUTHOR’S INTRODUCTION These unpublished monographs are being deposited in several libraries. They have their roots in my experience as a law student. I have been interested in the case of Slater v. Baker and Stapleton since I first learned of it in law school. I was privileged to be a member of the Yale School Class of 1974. I took an elective course with Dr. Jay Katz on the protection of human subjects and then served as a research assistant to Dr. Katz in the summers of 1973 and 1974. Dr. Katz’s course used his new book EXPERIMENTATION WITH HUMAN BEINGS (New York: Russell Sage Foundation 1972). On pages 526-527, there are excerpts from Slater v. Baker. I sought out and read Slater v. Baker. It seemed that there must be an interesting backstory to the case, but it was not accessible at that time. I then practiced health law for nearly forty years, representing hospitals and doctors, and writing six editions of a textbook on hospital law. I applied my interest in experimentation with human beings by serving on various Institutional Review Boards (IRBs) during that period. IRBs are federally required committees that review and approve experiments with humans at hospitals, universities and other institutions. -
Shakspere and the Medical Sciences
THE BRISTOL fll>eMco=Cbiriu*gical Journal. DECEMBER, 1887. , J SHAKSPERE AND THE MEDICAL SCIENCES. ftbe presidential BDfcress at tbe opening, on October I2tb, 1SS7, of tbe Utb Session of tbe JGrlstol /nbcOtco = Cblrnrgleal Society BY L. M. Griffiths, M.R.C.S. Eng., L.R.C.P. Ed. It has almost become a stereotyped plan for the president of a society like ours to introduce into his address, by way of preface, a statement, more or less in detail, that for the fulfilment of the.duties of the office he is much less capable than any of his predecessors. This is probably an out- come of the retiring modesty of the Profession in its individual capacity and of the desire to carry out the apostolic precept of esteeming others better than one's self. If it were absolutely true?and if it were a fact that the welfare of the constitution depended upon the nominal 17 226 MR. L. M. GRIFFITHS president a society which had got to its fourteenth session with a steady deterioration constantly going on would indeed be in a sad state. I shall try to avoid the mistake of offering this customary apology, because to doubt the wisdom of the choice of the members seems to me to cast a slur upon the intelligence of the electing body, and I think it is more becoming, when elected, to enter manfully into the duties of the office and do the best that in one lies. But the choice of the subject of an address involved considerable difficulty. -
Mencan Rock Garden Society
Bulletin of the mencan Rock Garden Society VOL. 42 50th Anniversary Issue NO. 5 THE BULLETIN Editor Laura Louise Foster, Falls Village, Conn. 06031 Assistant Editor Harry Dewey, 4605 Brandon Lane, Beltsville, MD. 20705 Contributing Editors Roy Davidson, Anita Kistler, H. Lincoln Foster, Owen Pearce, H.N. Porter Layout Designer Buffy Parker Advertising Manager . .Anita Kistler, 1421 Ship Rd., West Chester, Pa. 19380 ANNIVERSARY ISSUE CONTENTS VOL. 42 NO. 5 1984 The Anniversary Celebration —L.L. Foster 1 The Pre-Conference Tour—Judy Glattstein 12 The Post-Conference Tour—Nickolas Nickou 18 As It Was in the Beginning—F.H. Cabot 22 The ARGS Hymn 51 Illustrations—Laura Louise Foster Published quarterly by the AMERICAN ROCK GARDEN SOCIETY, a tax-exempt, non-profit organization incorporated under the laws of the state of New Jersey. You are invited to join. Annual dues (Bulletin included), to be submitted in U.S. Funds or International Money Order, are: General Membership, $15.00 (includes domestic or foreign, single or joint—2 at same address to receive 1 Bulletin, 1 Seed List); Patron, $50.00; Life Member, $250.00. Membership inquiries and dues should be sent to Norman Singer, Secretary, SR 66 Box 114, Norfolk Rd., Sandisfield, Mass. 01255. The office of publication is located at Norfolk Rd., Sandisfield, Mass. 01255. Address editorial matters per• taining to the Bulletin to the Editor, Laura Louise Foster. Falls Village, Conn. 06031. Address advertising matters to Anita Kistler, 1421 Ship Rd., West Chester, Pa. 19380. Second Class Postage paid in Sandisfield, Mass. and additional offices. Bulletin of the American Rock Garden Society (ISSN 0003-0864). -
Download Thesis
This electronic thesis or dissertation has been downloaded from the King’s Research Portal at https://kclpure.kcl.ac.uk/portal/ Religion, Medicine and Confessional Identity in Early Modern England Mann, Sophie Liana Awarding institution: King's College London The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without proper acknowledgement. END USER LICENCE AGREEMENT Unless another licence is stated on the immediately following page this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence. https://creativecommons.org/licenses/by-nc-nd/4.0/ You are free to copy, distribute and transmit the work Under the following conditions: Attribution: You must attribute the work in the manner specified by the author (but not in any way that suggests that they endorse you or your use of the work). Non Commercial: You may not use this work for commercial purposes. No Derivative Works - You may not alter, transform, or build upon this work. Any of these conditions can be waived if you receive permission from the author. Your fair dealings and other rights are in no way affected by the above. Take down policy If you believe that this document breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 26. Sep. 2021 Religion, Medicine and Confessional Identity in Early Modern England by Sophie Liana Mann Department of History, King’s College London Submitted for the degree of Doctor of Philosophy in History, March 2014 1 Abstract Early modern historians often frame ‘religion’ and ‘medicine’ as distinct categories of experience and conduct. -
Orme) Wilberforce (Albert) Raymond Blackburn (Alexander Bell
Copyrights sought (Albert) Basil (Orme) Wilberforce (Albert) Raymond Blackburn (Alexander Bell) Filson Young (Alexander) Forbes Hendry (Alexander) Frederick Whyte (Alfred Hubert) Roy Fedden (Alfred) Alistair Cooke (Alfred) Guy Garrod (Alfred) James Hawkey (Archibald) Berkeley Milne (Archibald) David Stirling (Archibald) Havergal Downes-Shaw (Arthur) Berriedale Keith (Arthur) Beverley Baxter (Arthur) Cecil Tyrrell Beck (Arthur) Clive Morrison-Bell (Arthur) Hugh (Elsdale) Molson (Arthur) Mervyn Stockwood (Arthur) Paul Boissier, Harrow Heraldry Committee & Harrow School (Arthur) Trevor Dawson (Arwyn) Lynn Ungoed-Thomas (Basil Arthur) John Peto (Basil) Kingsley Martin (Basil) Kingsley Martin (Basil) Kingsley Martin & New Statesman (Borlasse Elward) Wyndham Childs (Cecil Frederick) Nevil Macready (Cecil George) Graham Hayman (Charles Edward) Howard Vincent (Charles Henry) Collins Baker (Charles) Alexander Harris (Charles) Cyril Clarke (Charles) Edgar Wood (Charles) Edward Troup (Charles) Frederick (Howard) Gough (Charles) Michael Duff (Charles) Philip Fothergill (Charles) Philip Fothergill, Liberal National Organisation, N-E Warwickshire Liberal Association & Rt Hon Charles Albert McCurdy (Charles) Vernon (Oldfield) Bartlett (Charles) Vernon (Oldfield) Bartlett & World Review of Reviews (Claude) Nigel (Byam) Davies (Claude) Nigel (Byam) Davies (Colin) Mark Patrick (Crwfurd) Wilfrid Griffin Eady (Cyril) Berkeley Ormerod (Cyril) Desmond Keeling (Cyril) George Toogood (Cyril) Kenneth Bird (David) Euan Wallace (Davies) Evan Bedford (Denis Duncan) -
The Healing Hand in Literature: Shakespeare and Surgery
Shakespeare and surgery Thehealinghandinliterature:Shakespeareandsurgery KTLFu The interplay between surgery and dramatic literature in the plays of Shakespeare is reviewed. This review attempts to explore medical references in Shakespeare’s works and to analyse the medical and social background of his time. Caution should be taken in interpreting Shakespeare’s works through a modern medical view; diseases and their therapy are used metaphorically as a means to an end in the Bard’s masterly hands. Shakespeare’s medical knowledge may be accounted for by his avid reading of contemporary medical texts, from primary or secondary sources; an astute sense of observation of Lon- don’s medical practitioners—bona fide or otherwise—and their activities and patients; and a medical connection by way of his son-in-law, Dr John Hall. It should be remembered that nothing in Nature stands alone; but every art and science has a relation to some other art or science, that it requires us to have a knowledge of those others, as this connexion takes place, to enable us to become perfect in that which engages our particular attention. John Hunter (1728-93) HKMJ 1998;4:77-88 Key words: History of medicine, ancient; History of medicine, medieval; History of medicine, 16th cent.; History of medicine, 17th cent.; History of medicine, 18th cent.; Medicine in literature Introduction seen. The patient’s history is the story of his life— his odyssey in the realm of disease. A primary This review attempts to explore the history of the source for the doctor is the personal history of dramatic representation of surgery and orthopaedics the patient which is in truth his life story. -
The Dissenting Tradition in English Medicine of the Seventeenth and Eighteenth Centuries
Medical History, 1995, 39: 197-218 The Dissenting Tradition in English Medicine of the Seventeenth and Eighteenth Centuries WILLIAM BIRKEN* In England, medicine has always been something of a refuge for individuals whose lives have been dislocated by religious and political strife. This was particularly true in the seventeenth century when changes in Church and State were occurring at a blinding speed. In his book The experience of defeat, Christopher Hill has described the erratic careers of a number of radical clergy and intellectuals who studied and practised medicine in times of dislocation. A list pulled together from Hill's book would include: John Pordage, Samuel Pordage, Henry Stubbe, John Webster, John Rogers, Abiezer Coppe, William Walwyn and Marchamont Nedham.1 Medicine as a practical option for a lost career, or to supplement and subsidize uncertain careers, can also be found among Royalists and Anglicans when their lives were similarly disrupted during the Interregnum. Among these were the brilliant Vaughan twins, Thomas, the Hermetic philosopher, and Henry, the metaphysical poet and clergyman; the poet, Abraham Cowley; and the mercurial Nedham, who was dislocated both as a republican and as a royalist. The Anglicans Ralph Bathurst and Mathew Robinson were forced to abandon temporarily their clerical careers for medicine, only to return to the Church when times were more propitious. In the middle of the eighteenth century the political and religious disabilities of non-juring Anglicanism were still potent enough to impel Sir Richard Jebb to a successful medical career. But by and large the greatest impact on medicine came from the much larger group of the displaced, the English Dissenters, whose combination of religion and medicine were nothing short of remarkable. -
Forty-Seventh Annual Meeting 47Of The
TH FORTY-SEVENTH ANNUAL MEETING 47OF THE November 21 – 23, 2019 The Marriott Marquis New York City, NY Alexander Vaccaro, MD, PhD, MBA, President Gregory D. Schroeder, MD and Justin Smith, MD, Scientific Program Co-Chairs Scientific Meeting Objectives • Present the results of current cervical spine research data. • Promote discussion of new developments and techniques. • Foster research concerning the diagnosis and treatment of cervical spine injury and disease. 9 Thursday, November 21 Broadway Ballroom, 6th Floor 7:00 am - 7:10 am Welcome and Announcements Moderators: Gregory D Schroeder, MD and Justin S Smith, MD, PhD 7:11 am - 7:51 am Session I: Outcomes I, Cervical Myelopathy Moderators: Kazuhiro Chiba, MD, Michael Fehlings, MD, PhD and Jefferson Wilson, MD 7:11 am - 7:16 am Presentation #1 The Impact Of Older Age On Functional Recovery After Surgical Decompression For Degenerative Cervical Myelopathy: Results From An International, Multicentre, Prospective Dataset In 757 Patients Jamie R F Wilson, MD; Jetan Hari Badhiwala, MD; Fan Jiang, FRCSC, MD; Jefferson R Wilson, FRCSC, MD, PhD; Branko Kopjar, MD, MS, PhD; Alexander Vaccaro, MD, PhD, MBA; Michael Fehlings, MD 7:17 am - 7:22 am Presentation #2 Surgical Treatment Of Cervical Spondylotic Myelopathy Leads To Functional Improvement In Hand Strength And Dexterity: A Prospective Quantitative Study Tyler S Cole, MD; Jakub Godzik, MD; Jay D Turner, MD, PhD 7:23 am - 7:28 am Presentation #3 Neck Pain Improvement After Operative Intervention In Patients With Degenerative Cervical Myelopathy: