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Contents • January 2020 • Volume 64, No. 1 CONTENTS • JANUARY 2020 • VOLUME 64, NO. 1 EDITORIAL Louis B. Rice R Acknowledgment of Ad Hoc Reviewers e02153-19 Editorial Louis B. Rice COMMENTARIES Cesar A. Arias R What’s Old Is New Again: Bacteriophage Therapy in the 21st Century e01987-19 Commentary Saima Aslam, Robert T. Schooley Cesar A. Arias R No Amikacin, No Problem: a Successful Treatment Approach for Pediatric e02023-19 Commentary Otomastoiditis Due to Amikacin-Resistant Mycobacterium abscessus William J. Richter, Keira A. Cohen Louis B. Rice R The Economic Conundrum for Antibacterial Drugs e02057-19 Commentary David M. Shlaes CHALLENGING CLINICAL CASES IN ANTIMICROBIAL RESISTANCE Cesar A. Arias T Bacteriophages as Adjuvant to Antibiotics for the Treatment of Periprosthetic e00924-19 Challenging Clinical Case Joint Infection Caused by Multidrug-Resistant Pseudomonas aeruginosa Tamta Tkhilaishvili, Tobias Winkler, Michael Müller, Carsten Perka, Andrej Trampuz Cesar A. Arias T Successful Systemic and Topical Treatment of Mycobacterium abscessus e01203-19 Challenging Clinical Case Otomastoiditis Floor van Wijk, Jérôme Waterval, Koen van Aerde, Stefanie S. V. Henriet, F. J. Anton Meijer, Lennaert C. Borra, Rob E. Aarnoutse, Jakko van Ingen Cesar A. Arias T A Dutch Case Report of Successful Treatment of Chronic Relapsing Urinary Tract e01281-19 Challenging Clinical Case Infection with Bacteriophages in a Renal Transplant Patient Saskia Kuipers, Mike M. Ruth, Mike Mientjes, Ruud G. L. de Sévaux, Jakko van Ingen MECHANISMS OF ACTION: PHYSIOLOGICAL EFFECTS Cesar A. Arias S DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced e01196-19 Mech of Action by Fluoroquinolones Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg David M. Shlaes T Influence of the ␣-Methoxy Group on the Reaction of Temocillin with e01473-19 Mech of Action Pseudomonas aeruginosa PBP3 and CTX-M-14 ␤-Lactamase Michael D. Sacco, Kyle G. Kroeck, M. Trent Kemp, Xiujun Zhang, Logan D. Andrews, Yu Chen Laurent Poirel T Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination e01587-19 Mech of Action with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa Maytham Hussein, Mei-Ling Han, Yan Zhu, Qi Zhou, Yu-Wei Lin, Robert E. W. Hancock, Daniel Hoyer, Darren J. Creek, Jian Li, Tony Velkov Sevtap T Antifungal Activity of Mammalian Serum Amyloid A1 against Candida albicans e01975-19 Arikan-Akdagli Mech of Action Jiao Gong, Jun Wu, Melanie Ikeh, Li Tao, Yulong Zhang, Jian Bing, Clarissa J. Nobile, Guanghua Huang Instructions to Authors are available on the journal website. CONTENTS • JANUARY 2020 • VOLUME 64, NO. 1 MECHANISMS OF RESISTANCE Wilbur K. Milhous T Genomic and Metabolomic Polymorphism among Experimentally Selected e00904-19 Mech of Resistance Paromomycin-Resistant Leishmania donovani Strains C. D. Shaw, H. Imamura, T. Downing, G. Blackburn, G. D. Westrop, J. A. Cotton, M. Berriman, M. Sanders, S. Rijal, G. H. Coombs, J. C. Dujardin, K. C. Carter Cesar A. Arias T cfr(B), cfr(C), and a New cfr-Like Gene, cfr(E), in Clostridium difficile Strains e01074-19 Mech of Resistance Recovered across Latin America Vanja Stojkovic´, María Fernanda Ulate, Fanny Hidalgo-Villeda, Emmanuel Aguilar, Camilo Monge-Cascante, Marjorie Pizarro-Guajardo, Kaitlyn Tsai, Edgardo Tzoc, Margarita Camorlinga, Daniel Paredes-Sabja, Carlos Quesada-Gómez, Danica Galonic´ Fujimori, César Rodríguez Cesar A. Arias T Capturing the Resistome: a Targeted Capture Method To Reveal Antibiotic e01324-19 Mech of Resistance Resistance Determinants in Metagenomes Allison K. Guitor, Amogelang R. Raphenya, Jennifer Klunk, Melanie Kuch, Brian Alcock, Michael G. Surette, Andrew G. McArthur, Hendrik N. Poinar, Gerard D. Wright Laurent Poirel S Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, e01326-19 Mech of Resistance Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate Liyuan Wang, Dejun Liu, Yuan Lv, Lanqing Cui, Yun Li, Tianmeng Li, Huangwei Song, Yuxin Hao, Jianzhong Shen, Yang Wang, Timothy R. Walsh Alessandra T High-Level Carbapenem Resistance in OXA-232-Producing Raoultella e01335-19 Carattoli Mech of Resistance ornithinolytica Triggered by Ertapenem Therapy Alina Iovleva, Roberta T. Mettus, Christi L. McElheny, Marissa P. Griffith, Mustapha M. Mustapha, A. William Pasculle, Ryan K. Shields, Vaughn S. Cooper, Yohei Doi David R. Andes T Evaluation of Resistance Development to the Gwt1 Inhibitor Manogepix e01387-19 Mech of Resistance (APX001A) in Candida Species Mili Kapoor, Molly Moloney, Quinlyn A. Soltow, Chris M. Pillar, Karen Joy Shaw David M. Shlaes T Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in e01490-19 Mech of Resistance Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms Adriana K. Jones, Ruth E. Caughlan, Angela L. Woods, Kyoko Uehara, Lili Xie, S. Whitney Barnes, John R. Walker, Katherine V. Thompson, Srijan Ranjitkar, Patrick S. Lee, Charles R. Dean Cesar A. Arias T Regulation and Anaerobic Function of the Clostridioides difficile ␤-Lactamase e01496-19 Mech of Resistance Brindar K. Sandhu, Adrianne N. Edwards, Sarah E. Anderson, Emily C. Woods, Shonna M. McBride Wilbur K. Milhous T Modification of pfap2␮ and pfubp1 Markedly Reduces Ring-Stage Susceptibility e01542-19 Mech of Resistance of Plasmodium falciparum to Artemisinin In Vitro Ryan C. Henrici, Donelly A. van Schalkwyk, Colin J. Sutherland David M. Shlaes S A Loop-Mediated Isothermal Amplification Assay Targeting Neisseria gonorrhoeae e01663-19 Mech of Resistance penA-60.001 Ken Shimuta, Shu-ichi Nakayama, Hideyuki Takahashi, Makoto Ohnishi Laurent Poirel T The Transcriptional Repressor SmvR Is Important for Decreased Chlorhexidine e01845-19 Mech of Resistance Susceptibility in Enterobacter cloacae Complex François Guérin, François Gravey, Patrick Plésiat, Marion Aubourg, Racha Beyrouthy, Richard Bonnet, Vincent Cattoir, Jean-Christophe Giard January 2020 Volume 64 Issue 1 Antimicrobial Agents and Chemotherapy aac.asm.org iii CONTENTS • JANUARY 2020 • VOLUME 64, NO. 1 Cesar A. Arias T The Sle1 Cell Wall Amidase Is Essential for ␤-Lactam Resistance in Community- e01931-19 Mech of Resistance Acquired Methicillin-Resistant Staphylococcus aureus USA300 Ida Thalsø-Madsen, Fernando Ruiz Torrubia, Lijuan Xu, Andreas Petersen, Camilla Jensen, Dorte Frees Alessandra S Improvement of the Immunochromatographic NG-Test Carba 5 Assay for the e01940-19 Carattoli Mech of Resistance Detection of IMP Variants Previously Undetected Hervé Volland, Delphine Girlich, Marine Laguide, Camille Gonzalez, Virginie Paris, Maxime Laroche, Saoussen Oueslati, Laurent Dortet, Stéphanie Simon, Thierry Naas SUSCEPTIBILITY David R. Andes T New Antifungal Susceptibility Test Based on Chitin Detection by Image e01101-19 Susceptibility Cytometry Yan Wang, Arisandy N. Andriampamonjy, Sebastien Bailly, Cécile Garnaud, Danièle Maubon, Muriel Cornet, Delphine Aldebert David M. Shlaes S Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five e01344-19 Susceptibility Quinazolinone Antibacterials Sara Ceballos, Choon Kim, Yuanyuan Qian, Shahriar Mobashery, Mayland Chang, Carmen Torres Sevtap S Pyomelanin Secretion in Madurella mycetomatis Interferes with Spectrophotometric e01532-19 Arikan-Akdagli Susceptibility Endpoint Reading Using the Sensititre YeastOne alamarBlue Assay but Not with Visual Endpoint Reading B. Nyuykonge, P. D. Croughs, A. H. Fahal, A. Verbon, W. W. J. van de Sande Helen Boucher T Activity of Meropenem with a Novel Broader-Spectrum ␤-Lactamase Inhibitor, e01666-19 Susceptibility WCK 4234, against Gram-Negative Pathogens Endemic to New York City Alejandro Iregui, Zeb Khan, David Landman, John Quale Louis B. Rice S Comparable In Vitro Activities of Second-Generation HIV-1 Integrase Strand e01717-19 Susceptibility Transfer Inhibitors (INSTIs) on HIV-1 Clinical Isolates with INSTI Resistance Mutations Francesco Saladini, Alessia Giannini, Adele Boccuto, Filippo Dragoni, Alice Appendino, Edoardo Albanesi, Ilaria Vicenti, Maurizio Zazzi BIOLOGIC RESPONSE MODIFIERS Jared A. Silverman T Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/ e01744-19 Modifiers PhoQ Signal Transduction System María Ayelén Carabajal, Christopher R. M. Asquith, Tuomo Laitinen, Graham J. Tizzard, Lucía Yim, Analía Rial, José A. Chabalgoity, William J. Zuercher, Eleonora García Véscovi ANTIVIRAL AGENTS Miguel Angel T Anti-inflammatory Compound Shows Therapeutic Safety and Efficacy against e00941-19 Martinez Antiviral Flavivirus Infection Fu-Kai Chuang, Shih-Ming Huang, Ching-Len Liao, An-Rong Lee, Shu-Pei Lien, Yu-Lung Chiu, Tsung-Hsien Chang, Pei-Ling Tsai, Ren-Jye Lin, Chih-Chin Shih, Yi-Jing Tsai, Gu- Jiun Lin, Li-Chen Yen Miguel Angel T Griffithsin Retains Anti-HIV-1 Potency with Changes in gp120 Glycosylation and e01084-19 Martinez Antiviral Complements Broadly Neutralizing Antibodies PGT121 and PGT126 Kathryn Fischer, Kimberly Nguyen, Patricia J. LiWang iv aac.asm.org Antimicrobial Agents and Chemotherapy Volume 64 Issue 1 January 2020 CONTENTS • JANUARY 2020 • VOLUME 64, NO. 1 Miguel Angel T A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus e01440-19 Martinez Antiviral Capsids and Prevent Virus Infection Chunkyu Ko, Romina Bester, Xue Zhou, Zhiheng Xu, Christoph Blossey, Julia Sacherl, Florian W. R. Vondran, Lu Gao, Ulrike Protzer Miguel Angel
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