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Product Information Product Information Griffithsin Item No. 10340 • Lot No. XXXX Synonym: GRFT Source: Recombinant N-terminal hexahistdine-tagged GRFT expressed in E. coli Amino Acids: 2-122 of GRFT (out of 139 total aa in protein) Accession No.: AMC42413 Mr: 14.6 kDa Purity: ≥95% Stability: ≥9 months at -80°C Supplied in: 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride, 2.5 mM DTT, and 20% glycerol Protein Concentration: batch specific mg/ml 1 2 3 4 Griffithsin (GRFT), is a lectin isolated from Griffithsia sp. with anti-HIV activity at subnanomolar concentrations.1 GRFT activity is glycosylation-dependent and acts by binding to glycoproteins gp41, gp120, and gp160 on the viral envelope, blocking the virus from binding to CD4 receptor-expressing cells in the host. It also prevents cell fusion between infected and uninfected cells, further inhibiting the spread of HIV in the body. GRFT functions as a homodimer, with each monomer containing three carbohydrate binding sites.1,2 GRFT’s unique anti-viral activity is of interest for use in microbicide production to stop transmission of HIV through sexual contact. It has also been shown to have inhibitory effects with SARS-related coronavirus; where GRFT binding to the SARS-CoV S protein can prevent viral entry and reduce viral load in succeeding rounds of infection.3 References 1. Mori, T., O’Keefe, B.R., Sowder, R.C., II, et al. Isolation and characterization of Lane 1: MW Marker griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. The Journal Lane 2: GRFT (5 µg) of Biological Chemistry 280(10) Lane 3: GRFT (2.5 µg) , 9345-9353 (2005). Lane 4: GRFT (1.25 µg) 2. Ziólkowska, N.E., O’Keefe, B.R., Mori, T., et al. Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure 14, 1127-1135 (2006). 3. O’Keefe, B.R., Giomarelli, B., Barnard, D.L., et al. Broad spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J. Virol. (2009). Related Products For a list of related products please visit: www.caymanchem.com/catalog/10340 Cayman Chemical Mailing address 1180 E. Ellsworth Road Ann Arbor, MI 48108 USA Phone (800) 364-9897 WARNING: THIS PRODUCT IS FOR LABOratORY RESEarCH ONLY: NOT FOR ADMiniStratiON TO HUManS. NOT FOR HUMan OR VETErinarY (734) 971-3335 DiagnOStiC OR THEraPEUtiC USE. SAFETY DATA Fax This material should be considered hazardous until information to the contrary becomes available. Do not ingest, swallow, or inhale. Do not get in eyes, on skin, or on clothing. Wash thoroughly after handling. This information contains some, but not all, of the information required for the safe and proper use of this material. Before use, the user must review the complete Safety Data Sheet, (734) 971-3640 which has been sent via email to your institution. WARRANTY AND LIMITATION OF REMEDY E-Mail Cayman Chemical Company makes no warranty or guarantee of any kind, whether written or oral, expressed or implied, including without limitation, any warranty of fitness for a particular [email protected] purpose, suitability and merchantability, which extends beyond the description of the chemicals hereof. Cayman warrants only to the original customer that the material will meet our specifications at the time of delivery. Cayman will carry out its delivery obligations with due care and skill. Thus, in no event will Cayman have any obligation or liability, whether in tort (including negligence) or in contract, for Web any direct, indirect, incidental or consequential damages, even if Cayman is informed about their possible existence. This limitation of liability does not apply in the case of intentional acts or negligence of Cayman, its directors or its employees. www.caymanchem.com Buyer’s exclusive remedy and Cayman’s sole liability hereunder shall be limited to a refund of the purchase price, or at Cayman’s option, the replacement, at no cost to Buyer, of all material that does not meet our specifications. Said refund or replacement is conditioned on Buyer giving written notice to Cayman within thirty (30) days after arrival of the material at its destination. Failure of Buyer to give said notice within thirty (30) days shall constitute a waiver by Buyer of all claims hereunder with respect to said material. For further details, please refer to our Warranty and Limitation of Remedy located on our website and in our catalog. Copyright Cayman Chemical Company, 08/15/2013.
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