DOCSLIB.ORG

Tools for Optimising Pharmacotherapy in Psychiatry (Therapeutic Drug Monitoring, Molecular Brain Imaging and Pharmacogenetic Tests): Focus on Antidepressants

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Tools for Optimising Pharmacotherapy in Psychiatry (Therapeutic Drug Monitoring, Molecular Brain Imaging and Pharmacogenetic Tests): Focus on Antidepressants The World Journal of Biological Psychiatry ISSN: (Print) (Online) Journal homepage: https://www.tandfonline.com/loi/iwbp20 Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants C. B. Eap, G. Gründer, P. Baumann, N. Ansermot, A. Conca, E. Corruble, S. Crettol, M. L. Dahl, J. de Leon, C. Greiner, O. Howes, E. Kim, R. Lanzenberger, J. H. Meyer, R. Moessner, H. Mulder, D. J. Müller, M. Reis, P. Riederer, H. G. Ruhe, O. Spigset, E. Spina, B. Stegman, W. Steimer, J. Stingl, S. Suzen, H. Uchida, S. Unterecker, F. Vandenberghe & C. Hiemke To cite this article: C. B. Eap, G. Gründer, P. Baumann, N. Ansermot, A. Conca, E. Corruble, S. Crettol, M. L. Dahl, J. de Leon, C. Greiner, O. Howes, E. Kim, R. Lanzenberger, J. H. Meyer, R. Moessner, H. Mulder, D. J. Müller, M. Reis, P. Riederer, H. G. Ruhe, O. Spigset, E. Spina, B. Stegman, W. Steimer, J. Stingl, S. Suzen, H. Uchida, S. Unterecker, F. Vandenberghe & C. Hiemke (2021): Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants, The World Journal of Biological Psychiatry, DOI: 10.1080/15622975.2021.1878427 To link to this article: https://doi.org/10.1080/15622975.2021.1878427 © 2021 The Author(s). Published by Informa Published online: 12 May 2021. UK Limited, trading as Taylor & Francis Group. Submit your article to this journal Article views: 722 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iwbp20 THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY https://doi.org/10.1080/15622975.2021.1878427 REVIEW ARTICLE Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants a,b,c,d,eà fà g a h,i j,k C. B. Eap ,G.Grunder€ , P. Baumann , N. Ansermot , A. Conca , E. Corruble , S. Crettola , M. L. Dahll, J. de Leonm , C. Greinern, O. Howeso, E. Kimp,q, R. Lanzenbergerr , J. H. Meyers, R. Moessnert, H. Mulderu,v,w,x,D.J.Muller€ y,z,aa, M. Reisab,ac, P. Riedererad,ae, H. G. Ruheaf,ag , O. Spigsetah,ai, E. Spinaaj , B. Stegmanak, W. Steimeral, J. Stinglam, S. Suzenan, H. Uchidaao, S. Untereckerap, F. Vandenberghea and C. Hiemkeaq aUnit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; bCenter for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; cSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland; dInstitute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland; eInstitute of Pharmaceutical Sciences of Western Switzerland, University of Lausanne, Switzerland, Geneva, Switzerland; fDepartment of Molecular Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; gDepartment of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; hDepartment of Psychiatry, Health Service District Bolzano, Bolzano, Italy; iDepartment of Child and Adolescent Psychiatry, South Tyrolean Regional Health Service, Bolzano, Italy; jINSERM CESP, Team MOODS, Service Hospitalo-Universitaire de Psychiatrie, Universite Paris Saclay, Le Kremlin Bicetre, France; kService Hospitalo-Universitaire de Psychiatrie, Hopital^ Bic^etre, Assistance Publique Hopitaux^ de Paris, Le Kremlin Bic^etre, France; lDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; mEastern State Hospital, University of Kentucky Mental Health Research Center, Lexington, KY, USA; nBundesinstitut fur€ Arzneimittel und Medizinprodukte, Bonn, Germany; oKing’s College London and MRC London Institute of Medical Sciences (LMS)-Imperial College, London, UK; pDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea; qDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea; rDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria; sCampbell Family Mental Health Research Institute, CAMH and Department of Psychiatry, University of Toronto, Toronto, Canada; tDepartment of Psychiatry and Psychotherapy, University of Tubingen,€ Tubingen,€ Germany; uDepartment of Clinical Pharmacy, Wilhelmina Hospital Assen, Assen, The Netherlands; vGGZ Drenthe Mental Health Services Drenthe, Assen, The Netherlands; wDepartment of Pharmacotherapy, Epidemiology and Economics, Department of Pharmacy and Pharmaceutical Sciences, University of Groningen, Groningen, The Netherlands; xDepartment of Psychiatry, Interdisciplinary Centre for Psychopathology and Emotion Regulation, University of Groningen, Groningen, The Netherlands; yCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; zDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada; aaDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; abDepartment of Biomedical and Clinical Sciences, Linkoping€ University, Linkoping,€ Sweden; acClinical Chemistry and Pharmacology, Skåne University Hospital, Lund, Sweden; adCenter of Mental Health, Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wurzburg,€ Wurzburg,€ Germany; aeDepartment of Psychiatry, University of Southern Denmark Odense, Odense, Denmark; afDepartment of Psychiatry, Radboudumc, Nijmegen, the Netherlands; agDonders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands; ahDepartment of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway; aiDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; ajDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy; akInstitut fur€ Pharmazie der Universit€at Regensburg, Regensburg, Germany; alInstitute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, Munich, Germany; amInstitute for Clinical Pharmacology, University Hospital of RWTH Aachen, Germany; anDepartment of Toxicology, Faculty of Pharmacy, Ankara University, Ankara, Turkey; aoDepartment of Neuropsychiatry, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan; apDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wurzburg,€ Wurzburg,€ Germany; aqDepartment of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany CONTACT CB Eap [email protected] Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Lausanne University Hospital and University of Lausanne, Hospital of Cery, Prilly-Lausanne, Switzerland; G Grunder€ [email protected] Department of Molecular Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; C Hiemke [email protected] Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany à Joint first authorship ß 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by- nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. 2 C. B. EAP ET AL. ABSTRACT ARTICLE HISTORY Objectives: More than 40 drugs are available to treat affective disorders. Individual selection of Received 16 July 2020 the optimal drug and dose is required to attain the highest possible efficacy and acceptable tol- Revised 20 October 2020 erability for every patient. Accepted 1 December 2020 Methods: This review, which includes more than 500 articles selected by 30 experts, combines KEYWORDS relevant knowledge on studies investigating the pharmacokinetics, pharmacodynamics and Antidepressants; brain pharmacogenetics of 33 antidepressant drugs and of 4 drugs approved for augmentation in imaging; precision cases of insufficient response to antidepressant monotherapy. Such studies typically measure medicine; pharmacogenet- drug concentrations in blood (i.e. therapeutic drug monitoring) and genotype relevant genetic ics; therapeutic polymorphisms of enzymes, transporters or receptors involved in drug metabolism or mechan- drug monitoring ism of action. Imaging studies, primarily positron emission tomography that relates drug con- centrations in blood and radioligand binding, are considered to quantify target structure occupancy by the antidepressant drugs in vivo. Results: Evidence is given that in vivo imaging, therapeutic drug monitoring and genotyping and/or phenotyping of drug metabolising enzymes should be an integral part in the develop- ment of any new antidepressant drug. Conclusions: To guide antidepressant drug therapy in everyday practice, there are multiple indi- cations such as uncertain adherence, polypharmacy, nonresponse and/or adverse reactions
Load more

Recommended publications
  • Use of Human Plasma Samples to Identify Circulating Drug Metabolites That Inhibit Cytochrome P450 Enzymes
    1521-009X/44/8/1217–1228$25.00 http://dx.doi.org/10.1124/dmd.116.071084 DRUG METABOLISM AND DISPOSITION Drug Metab Dispos 44:1217–1228, August 2016 Copyright ª 2016 by The American Society for Pharmacology and Experimental Therapeutics Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes Heather Eng and R. Scott Obach Pfizer Inc., Groton, Connecticut Received April 19, 2016; accepted June 3, 2016 ABSTRACT Drug interactions elicited through inhibition of cytochrome P450 fractions were tested for inhibition of six human P450 enzyme (P450) enzymes are important in pharmacotherapy. Recently, activities (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and greater attention has been focused on not only parent drugs CYP3A4). Observation of inhibition in fractions that correspond to inhibiting P450 enzymes but also on possible inhibition of these the retention times of metabolites indicates that the metabolite Downloaded from enzymes by circulating metabolites. In this report, an ex vivo method has the potential to contribute to P450 inhibition in vivo. Using whereby the potential for circulating metabolites to be inhibitors of this approach, norfluoxetine, hydroxyitraconazole, desmethyldiltia- P450 enzymes is described. To test this method, seven drugs and zem, desacetyldiltiazem, desethylamiodarone, hydroxybupropion, their known plasma metabolites were added to control human erythro-dihydrobupropion, and threo-dihydrobupropion were iden- plasma at concentrations previously reported to occur in humans
    [Show full text]
  • K+ Channel Modulators Product ID Product Name Description D3209 Diclofenac Sodium Salt NSAID; COX-1/2 Inhibitor, Potential K+ Channel Modulator
    K+ Channel Modulators Product ID Product Name Description D3209 Diclofenac Sodium Salt NSAID; COX-1/2 inhibitor, potential K+ channel modulator. G4597 18β-Glycyrrhetinic Acid Triterpene glycoside found in Glycyrrhiza; 15-HPGDH inhibitor, hERG and KCNA3/Kv1.3 K+ channel blocker. A4440 Allicin Organosulfur found in garlic, binds DNA; inwardly rectifying K+ channel activator, L-type Ca2+ channel blocker. P6852 Propafenone Hydrochloride β-adrenergic antagonist, Kv1.4 and K2P2 K+ channel blocker. P2817 Phentolamine Hydrochloride ATP-sensitive K+ channel activator, α-adrenergic antagonist. P2818 Phentolamine Methanesulfonate ATP-sensitive K+ channel activator, α-adrenergic antagonist. T7056 Troglitazone Thiazolidinedione; PPARγ agonist, ATP-sensitive K+ channel blocker. G3556 Ginsenoside Rg3 Triterpene saponin found in species of Panax; γ2 GABA-A agonist, Kv7.1 K+ channel activator, α10 nAChR antagonist. P6958 Protopanaxatriol Triterpene sapogenin found in species of Panax; GABA-A/C antagonist, slow-activating delayed rectifier K+ channel blocker. V3355 Vindoline Semi-synthetic vinca alkaloid found in Catharanthus; Kv2.1 K+ channel blocker and H+/K+ ATPase inhibitor. A5037 Amiodarone Hydrochloride Voltage-gated Na+, Ca2+, K+ channel blocker, α/β-adrenergic antagonist, FIASMA. B8262 Bupivacaine Hydrochloride Monohydrate Amino amide; voltage-gated Na+, BK/SK, Kv1, Kv3, TASK-2 K+ channel inhibitor. C0270 Carbamazepine GABA potentiator, voltage-gated Na+ and ATP-sensitive K+ channel blocker. C9711 Cyclovirobuxine D Found in Buxus; hERG K+ channel inhibitor. D5649 Domperidone D2/3 antagonist, hERG K+ channel blocker. G4535 Glimepiride Sulfonylurea; ATP-sensitive K+ channel blocker. G4634 Glipizide Sulfonylurea; ATP-sensitive K+ channel blocker. I5034 Imiquimod Imidazoquinoline nucleoside analog; TLR-7/8 agonist, KCNA1/Kv1.1 and KCNA2/Kv1.2 K+ channel partial agonist, TREK-1/ K2P2 and TRAAK/K2P4 K+ channel blocker.
    [Show full text]
  • Aerobic Treatment of Selective Serotonin Reuptake Inhibitors in Landfill Leachate Ove Bergersen1*, Kine Østnes Hanssen2 and Terje Vasskog2,3
    Bergersen et al. Environmental Sciences Europe (2015) 27:6 DOI 10.1186/s12302-014-0035-0 RESEARCH Open Access Aerobic treatment of selective serotonin reuptake inhibitors in landfill leachate Ove Bergersen1*, Kine Østnes Hanssen2 and Terje Vasskog2,3 Abstract Background: Pharmaceuticals used in human medical care are not completely eliminated in the human body and can enter the municipal sewage sludge system and leachate water from landfill both as the parent compound and as their biologically active metabolites. The selective serotonin reuptake inhibitors (SSRIs) have a large potential for unwanted effects on nontarget organisms in the environment. Leachates from active or old closed landfills are often treated with continuous stirring and simple aeration in a pond/lagoon before infiltration into the environment. The aim of this work was to simulate the reduction of five SSRIs (citalopram, fluoxetine, paroxetine, sertraline and fluvoxamine) and three of their metabolites (desmethylcitalopram, didesmethylcitalopram and norfluoxetine) during aerobic treatment of leachate from landfills. This landfill leachate-simulation experiment was performed to see what happens with the pharmaceuticals during aerated treatment and continuous stirring of landfill leachate for 120 h. It is important to establish whether different pollutants such as pharmaceuticals can be removed (oxidized or otherwise degraded) or not before infiltration into the environment. Results: All the SSRIs had a significant concentration reduction during the aeration treatment process. Total SSRI concentrations were reduced significantly during aerobic treatment, and the individual SSRIs were reduced by 89% to 100% after 120 h. Among the high-concentration samples, fluoxetine (10 mg L−1) was the least degraded with 93% concentration reduction.
    [Show full text]
  • Development of Pain-Free Methods for Analyzing 231 Multiclass Drugs and Metabolites by LC-MS/MS
    Clinical, Forensic & Toxicology Article “The Big Pain”: Development of Pain-Free Methods for Analyzing 231 Multiclass Drugs and Metabolites by LC-MS/MS By Sharon Lupo As the use of prescription and nonprescription drugs grows, the need for fast, accurate, and comprehensive methods is also rapidly increasing. Historically, drug testing has focused on forensic applications such as cause of death determinations or the detection of drug use in specific populations (military, workplace, probation/parole, sports doping). However, modern drug testing has expanded well into the clinical arena with a growing list of target analytes and testing purposes. Clinicians often request the analysis of large panels of drugs and metabolites that can be used to ensure compliance with prescribed pain medication regimens and to detect abuse or diversion of medications. With prescription drug abuse reaching epidemic levels [1], demand is growing for analytical methods that can ensure accurate results for comprehensive drug lists with reasonable analysis times. LC-MS/MS is an excellent technique for this work because it offers greater sensitivity and specificity than immunoassay and—with a highly selective and retentive Raptor™ Biphenyl column—can provide definitive results for a wide range of compounds. Typically, forensic and pain management drug testing consists of an initial screening analysis, which is qualitative, quick, and requires only minimal sample preparation. Samples that test positive during screening are then subjected to a quantitative confirmatory analysis. Whereas screening assays may cover a broad list of compounds and are generally less sensitive and specific, confirmation testing provides fast, targeted analysis using chromatographic conditions that are optimized for specific panels.
    [Show full text]
  • FROM the LITERATURE PET in Assessment of Abuse Potential
    NEWSLINE FROM THE LITERATURE Each month the editor of Newsline drug radafaxine ([2S,3S])-2-[3-chlo- in the putamen. The authors con- selects articles on diagnostic, thera- rophenyl]-3,5,5,-trimethyl-2-mor- cluded that these and other data “sug- peutic, research, and practice issues pholinol hydrochloride). Radafaxine gest that the neurodegenerative from a range of international publica- is a potent metabolite of bupropion process in PD follows a negative ex- tions. Most selections come from out- that is being evaluated both as a treat- ponential course and slows down side the standard canon of nuclear ment for depression and for possible with increasing symptom duration, medicine and radiology journals. Note use in treatment of obesity. The study contradicting the long-latency hypo- that although we have divided the ar- included 8 healthy men who under- thesis of PD.” ticles into diagnostic and therapeutic went 11C-cocaine PET imaging at 1, Archives of Neurology categories, these lines are increasingly 4, 8, and 24 hours after radafaxine blurred as nuclear medicine capabili- administration. The authors found ties rapidly expand. Many diagnostic that DAT blockade by radafaxine PET and rCBF in Cocaine capabilities are now enlisted in direct was slow, reaching 11% at 1 hour Use Disorder support of and, often, in real-time con- and a peak blockade of 22% at 4 In an article e-published ahead of junction with, therapies. These briefs hours. The maximum blockade in print in the March 9 issue of the are offered as a monthly window on the any single subject was 33%.
    [Show full text]
  • Compositions and Methods for Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types
    (19) TZZ ¥Z_T (11) EP 2 380 595 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 26.10.2011 Bulletin 2011/43 A61K 47/48 (2006.01) C12N 15/11 (2006.01) A61P 25/00 (2006.01) A61K 49/00 (2006.01) (2006.01) (21) Application number: 10382087.4 A61K 51/00 (22) Date of filing: 19.04.2010 (84) Designated Contracting States: • Alvarado Urbina, Gabriel AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Nepean Ontario K2G 4Z1 (CA) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL • Bortolozzi Biassoni, Analia Alejandra PT RO SE SI SK SM TR E-08036, Barcelona (ES) Designated Extension States: • Artigas Perez, Francesc AL BA ME RS E-08036, Barcelona (ES) • Vila Bover, Miquel (71) Applicant: Nlife Therapeutics S.L. 15006 La Coruna (ES) E-08035, Barcelona (ES) (72) Inventors: (74) Representative: ABG Patentes, S.L. • Montefeltro, Andrés Pablo Avenida de Burgos 16D E-08014, Barcelon (ES) Edificio Euromor 28036 Madrid (ES) (54) Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types (57) The invention provides a conjugate comprising nucleuc acid toi cell of interests and thus, for the treat- (i) a nucleic acid which is complementary to a target nu- ment of diseases which require a down-regulation of the cleic acid sequence and which expression prevents or protein encoded by the target nucleic acid as well as for reduces expression of the target nucleic acid and (ii) a the delivery of contrast agents to the cells for diagnostic selectivity agent which is capable of binding with high purposes.
    [Show full text]
  • 2019 Instrumentation and Consumable Catalog 2 INSTRUMENTATION and CONSUMABLE CATALOG
    PRODUCT CATALOG 2019 Instrumentation and Consumable Catalog 2 INSTRUMENTATION AND CONSUMABLE CATALOG Resolvex® A200 Part Numbers: A200 96: 253-1160 Resolvex® A200 96 Resolvex A200 Standalone work station for automated sample preparation. The compact benchtop offers the one stop solution for automating sample preparation utilizing creation of multiple work flows, and programmable dispensing of up to 11 solvents. Along with its innovative positive pressure system leading to clean samples, improving accuracy, throughput and enhancing the Life time of your analytical instrument. The A200 comes with an easy to use touch screen interface allowing for easy set up of multiple work flows. In addition the light curtain safety feature will release gas pressure when manifold is activated to prevent any injuries. INSTRUMENTATION AND CONSUMABLE CATALOG 3 Resolvex® A100 Part Numbers: A100 96: 253-0019 A100 48: 253-0014 Resolvex® A100 Standalone work station for automated sample preparation. The compact benchtop offers the one stop solution for automating sample preparation utilizing creation of multiple work flows, and programmable dispensing of up to 11 solvents. Along with its innovative positive pressure system leading to clean samples, improving accuracy, throughput and enhancing the Life time of your analytical instrument. The A100 comes in 96 and 4 configuration allowing for for automated Work Flow solutions in multiple SPE formats. 4 INSTRUMENTATION AND CONSUMABLE CATALOG Resolvex® M10 96/M10 96 XT/M10 48 Part Numbers: M10 96 XT: 288-0006 M10 96: 288-0001 M10 48: 289-0004 Resolvex® M10 Standalone work station for Positive Pressure solid phase extraction. The manual Resolvex M10 48 and 96 are positive pressure manifold for 1, 3, and 6 ml cartridges, or 1ml 96 well plates.
    [Show full text]
  • Study Protocol 64565111EDI1002
    NCT03586830 Janssen Research & Development * Clinical Protocol Protocol Title A Randomized, Double-blind Placebo-controlled, Parallel-group, Multicenter, Dose- ranging Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Severely Obese Subjects with Type 2 Diabetes Mellitus Short Title Evaluation of JNJ-64565111 in Severely Obese Subjects with Type 2 Diabetes Mellitus Protocol 64565111OBE2002; Phase 2b AMENDMENT 1 JNJ-64565111 *Janssen Research & Development is a global organization that operates through different legal entities in various countries. Therefore, the legal entity acting as the sponsor for Janssen Research & Development studies may vary, such as, but not limited to Janssen Biotech, Inc.; Janssen Products, LP; Janssen Biologics, BV; Janssen-Cilag International NV; Janssen, Inc; Janssen Pharmaceutica NV; Janssen Sciences Ireland UC; or Janssen Research & Development, LLC. The term “sponsor” is used throughout the protocol to represent these various legal entities; the sponsor is identified on the Contact Information page that accompanies the protocol. US sites of this study will be conducted under US Food & Drug Administration IND regulations (21 CFR Part 312).] Status: Approved Date: 23 August 2018 Prepared by: Janssen Research & Development, LLC EDMS number: EDMS-ERI-156156741, 2.0 GCP Compliance: This study will be conducted in compliance with Good Clinical Practice, and applicable regulatory requirements. Confidentiality Statement The information in this document contains trade secrets and commercial information that are privileged or confidential and may not be disclosed unless such disclosure is required by applicable law or regulations. In any event, persons to whom the information is disclosed must be informed that the information is privileged or confidential and may not be further disclosed by them.
    [Show full text]
  • Phenylmorpholines and Analogues Thereof Phenylmorpholine Und Analoge Davon Phenylmorpholines Et Analogues De Celles-Ci
    (19) TZZ __T (11) EP 2 571 858 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C07D 265/30 (2006.01) A61K 31/5375 (2006.01) 20.06.2018 Bulletin 2018/25 A61P 25/24 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) (21) Application number: 11723158.9 (86) International application number: (22) Date of filing: 20.05.2011 PCT/US2011/037361 (87) International publication number: WO 2011/146850 (24.11.2011 Gazette 2011/47) (54) PHENYLMORPHOLINES AND ANALOGUES THEREOF PHENYLMORPHOLINE UND ANALOGE DAVON PHENYLMORPHOLINES ET ANALOGUES DE CELLES-CI (84) Designated Contracting States: • DECKER, Ann Marie AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Durham, North Carolina 27713 (US) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (74) Representative: Hoeger, Stellrecht & Partner Patentanwälte mbB (30) Priority: 21.05.2010 US 347259 P Uhlandstrasse 14c 70182 Stuttgart (DE) (43) Date of publication of application: 27.03.2013 Bulletin 2013/13 (56) References cited: WO-A1-2004/052372 WO-A1-2008/026046 (73) Proprietors: WO-A1-2008/087512 DE-B- 1 135 464 • Research Triangle Institute FR-A- 1 397 563 GB-A- 883 220 Research Triangle Park, North Carolina 27709 GB-A- 899 386 US-A1- 2005 267 096 (US) • United States of America, as represented by • R.A. GLENNON ET AL.: "Beta-Oxygenated The Secretary, Department of Health and Human Analogues of the 5-HT2A Serotonin Receptor Services Agonist Bethesda, Maryland 20892-7660 (US) 1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopro pane", JOURNAL OF MEDICINAL CHEMISTRY, (72) Inventors: vol.
    [Show full text]
  • Tools for Optimising Pharmacotherapy in Psychiatry (Therapeutic Drug Monitoring, Molecular Brain Imaging and Pharmacogenetic Tests): Focus on Antidepressants
    The World Journal of Biological Psychiatry ISSN: (Print) (Online) Journal homepage: https://www.tandfonline.com/loi/iwbp20 Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants C. B. Eap, G. Gründer, P. Baumann, N. Ansermot, A. Conca, E. Corruble, S. Crettol, M. L. Dahl, J. de Leon, C. Greiner, O. Howes, E. Kim, R. Lanzenberger, J. H. Meyer, R. Moessner, H. Mulder, D. J. Müller, M. Reis, P. Riederer, H. G. Ruhe, O. Spigset, E. Spina, B. Stegman, W. Steimer, J. Stingl, S. Suzen, H. Uchida, S. Unterecker, F. Vandenberghe & C. Hiemke To cite this article: C. B. Eap, G. Gründer, P. Baumann, N. Ansermot, A. Conca, E. Corruble, S. Crettol, M. L. Dahl, J. de Leon, C. Greiner, O. Howes, E. Kim, R. Lanzenberger, J. H. Meyer, R. Moessner, H. Mulder, D. J. Müller, M. Reis, P. Riederer, H. G. Ruhe, O. Spigset, E. Spina, B. Stegman, W. Steimer, J. Stingl, S. Suzen, H. Uchida, S. Unterecker, F. Vandenberghe & C. Hiemke (2021): Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants, The World Journal of Biological Psychiatry, DOI: 10.1080/15622975.2021.1878427 To link to this article: https://doi.org/10.1080/15622975.2021.1878427 © 2021 The Author(s). Published by Informa Published online: 12 May 2021. UK Limited, trading as Taylor & Francis Group. Submit your article to this journal Article views: 1134 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iwbp20 THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY https://doi.org/10.1080/15622975.2021.1878427 REVIEW ARTICLE Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants a,b,c,d,eà fà g a h,i j,k C.
    [Show full text]
  • Modifications to the Harmonized Tariff Schedule of the United States To
    U.S. International Trade Commission COMMISSIONERS Shara L. Aranoff, Chairman Daniel R. Pearson, Vice Chairman Deanna Tanner Okun Charlotte R. Lane Irving A. Williamson Dean A. Pinkert Address all communications to Secretary to the Commission United States International Trade Commission Washington, DC 20436 U.S. International Trade Commission Washington, DC 20436 www.usitc.gov Modifications to the Harmonized Tariff Schedule of the United States to Implement the Dominican Republic- Central America-United States Free Trade Agreement With Respect to Costa Rica Publication 4038 December 2008 (This page is intentionally blank) Pursuant to the letter of request from the United States Trade Representative of December 18, 2008, set forth in the Appendix hereto, and pursuant to section 1207(a) of the Omnibus Trade and Competitiveness Act, the Commission is publishing the following modifications to the Harmonized Tariff Schedule of the United States (HTS) to implement the Dominican Republic- Central America-United States Free Trade Agreement, as approved in the Dominican Republic-Central America- United States Free Trade Agreement Implementation Act, with respect to Costa Rica. (This page is intentionally blank) Annex I Effective with respect to goods that are entered, or withdrawn from warehouse for consumption, on or after January 1, 2009, the Harmonized Tariff Schedule of the United States (HTS) is modified as provided herein, with bracketed matter included to assist in the understanding of proclaimed modifications. The following supersedes matter now in the HTS. (1). General note 4 is modified as follows: (a). by deleting from subdivision (a) the following country from the enumeration of independent beneficiary developing countries: Costa Rica (b).
    [Show full text]
  • The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances
    WHO/PSM/QSM/2006.3 The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2006 Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines Medicines Policy and Standards The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 © World Health Organization 2006 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
    [Show full text]