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The Development of Cryo-Electron Microscopy SNI/Biozentrum Lecture on the Technology Recognized by the Nobel Prize 2017

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The Development of Cryo-Electron Microscopy SNI/Biozentrum Lecture on the Technology Recognized by the Nobel Prize 2017 11 April 2018, 4 – 6 pm Lecture Hall 1 Biozentrum/Pharmazentrum Klingelbergstrasse 50/70 Basel The development of cryo-electron microscopy SNI/Biozentrum Lecture on the technology recognized by the Nobel Prize 2017 Prof. em. Jacques Dubochet Nobel Prize Laureate 2017 University of Lausanne Prof. em. Ueli Aebi, Biozentrum, University of Basel Prof. em. Andreas Engel, Biozentrum, University of Basel Prof. em. Ueli Aebi Program Ueli Aebi was Professor of Structural Biology at the Biozentrum from 1986 to 2011. He was 04.00 Welcome address co-founder and the director of the Maurice E. Prof. Christian Schönenberger, Müller Institute for Structural Biology, as well as Swiss Nanoscience Institute, University of Basel a member of the Swiss Nanoscience Institute and the NCCR Nanoscale Science. In 1977, 04.10 Swiss efforts into cryo-electron microscopy Ueli Aebi had graduated in biophysics in the lab Prof. em. Ueli Aebi, Biozentrum, University of Basel of Prof. Eduard Kellenberger, one of the found- ing professors of the Biozentrum. His pioneering 04.30 The science that got me the Nobel Prize, work led to the development of new applica- and the science that didn’t. tions that have opened the doors to Prof. em. Jacques Dubochet, University of Lausanne nano-medicine. 05.10 Structural Biology goes from x-rays to electrons Prof. em. Andreas Engel, Biozentrum, University of Basel Prof. em. Jacques Dubochet The biophysicist Jacques Dubochet is the co-recipient 05.40 Closing remarks of the 2017 Nobel Prize in Chemistry for developing Prof. Christian Schönenberger cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution. 05.50 Apéro Jacques Dubochet studied physics at the EPFL. From 1971 to 1978, he carried out research at the University of Geneva and at the Biozentrum where in 1974 he received his PhD from Eduard Kellenberger. Subse- Professor emeritus Jacques Dubochet was awarded the Nobel Prize in quently, he became group leader at the European Chemistry 2017 for the joint development of cryo-electron microscopy Molecular Biology Laboratory (EMBL) in Heidelberg. together with Professor Joachim Frank and Professor Richard Henderson. From 1987 until his retirement in 2007, he was Their invention has revolutionized biochemistry and has enabled scientists professor at the University of Lausanne. worldwide to capture every corner of a cell in atomic detail. Jacques Dubochet and his long-time colleagues Andreas Engel and Ueli Aebi Prof. em. Andreas Engel have shaped structural biology at the Biozentrum of the University of Basel Andreas Engel pioneered the application of scanning trans- for many years through the Maurice Müller Institute, paving the way to the mission electron microscopy (STEM) and atomic force micros- establishment of the Swiss Nanoscience Institute at the University of Basel. copy (AFM) to image biomolecular complexes. Andreas Engel They will share their insights into the fascinating world of electron micros- who had received his PhD in 1972 from the University of copy with us. Bern, joined the Biozentrum in 1974 where he established a STEM platform in Eduard Kellenberger’s group. In 1986, Engel became Professor of Structural Biology. Together with Ueli Aebi he established the Maurice E. Müller Institute for Structural Biology and together with colleagues from the Departments of Chemistry and Physics, he established the nano study program at the Swiss Nanoscience Institute. Swiss Nanoscience Institute Klingelbergstrasse 82 4056 Basel www.nanoscience.ch Biozentrum, University of Basel Klingelbergstrasse 50/70 4056 Basel www.biozentrum.unibas.ch.
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