DOCSLIB.ORG

Preferred Drug List Drug Class Review Announcement

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Preferred Drug List Drug Class Review Announcement PDL Drug Class Review Announcement January 12, 2021 Drug Classes to be reviewed: Anti-Parkinson’s Agents; Calcitonin-Gene Receptor Protein (CGRP) Inhibitors; Atypical Antipsychotics – Oral; Anxiolytics; Bile salts; Cardiovascular – Alpha-Blockers, Beta-Blockers & Combinations, Calcium Channel Blockers; Diabetes Management – Insulins; Glucagon, Self-Administered; Growth Hormones; Hemorrhoidal, Anorectal and Related Topical Anesthetic Agents; Immune Globulins; Intranasal Rhinitis Agents; Leukotriene Modifiers; Lipotropics – Statins, Statin Combinations, Other; Lithium Agents; Multiple Sclerosis Agents; Neurocognitive Disorder Agents; Ophthalmics - Allergy Agents, Anti-Inflammatory Agents, Glaucoma Agents; Sedative/Hypnotics - Non-Benzodiazepine, Benzodiazepine; and Topical Steroids – Low, Medium, High, Very High Potency. These drug classes will be reviewed at the January 12, 2021 P&T Committee meeting from 1-5pm. The meeting will be held virtually. Dossiers and Supplemental Rebate offers are due to Magellan by December 8, 2020. Please provide your public comments to Jessica Czechowski, Clinical Account Manager ([email protected]) no later than January 5, 2021 to ensure they are included in the information supplied to the P&T Committee members. Please carbon copy Brittany Schock, PDL Pharmacist ([email protected]) on all clinical information and public comment submissions. Anti-Parkinson’s Agents Brand Name Generic Name Dopa Decarboxylase Inhibitors Carbidopa/Levodopa ER tablet, ODT Duopa Carbidopa/Levodopa enteral suspension Inbrija Levodopa capsule for inhalation Lodosyn Carbidopa tablet Carbidopa tablet Rytary ER Carbidopa/Levodopa ER capsule Sinemet Carbidopa/Levodopa tablet Carbidopa/Levodopa tablet Stalevo Carbidopa/Levodopa/Entacapone tablet Carbidopa/Levodopa/Entacapone tablet Dopamine Agonists Pramipexole tablet Ropinirole tablet Apokyn Apomorphine cartridge Kynmobi Apomorphine sublingual film Mirapex ER Pramipexole ER tablet Pramipexole ER tablet Neupro Rotigotine patch Parlodel Bromocriptine capsule, tablet Bromocriptine capsule, tablet Requip XL Ropinirole ER tablet Ropinirole ER tablet MAO-B Inhibitors Selegiline capsule, tablet Azilect Rasagiline tablet Rasagiline tablet Zelapar Selegiline ODT tablet Xadago Safinamide tablet Other Agents Amantadine capsule, solution, tablet Benztropine Mesylate tablet Trihexyphenidyl elixir, tablet Comtan Entacapone tablet Entacapone tablet Gocovri ER Amantadine ER capsule Nourianz Istradefylline tablet Ongentys Opicapone capsule Osmolex ER Amantadine ER tablet Tasmar Tolcapone tablet Tolcapone tablet Atypical Antipsychotics, Oral Brand Name Generic Name Abilify/Abilify Mycite Aripiprazole tablet, Mycite Kit Aripiprazole tablet, ODT tablet, oral solution Caplyta Lumateperone capsule Clozaril Clozapine tabs, ODT Clozapine tabs, ODT Fanapt Iloperidone tablet, pack Fazaclo Clozapine ODT Geodon Ziprasidone capsule Ziprasidone capsule Invega ER Paliperidone ER tablet Paliperidone ER tablet Latuda Lurasidone tablet Nuplazid Pimavanserin capsule, tablet Rexulti Brexpiprazole tablet Risperdal Risperidone tablet, oral solution Risperidone tablet, ODT, oral solution Saphris Asenapine SL tablet Secuado Asenapine patch Seroquel/Seroquel XR Quetiapine tablet, ER tablet Quetiapine tablet, ER tablet Symbyax Olanzapine/fluoxetine capsule Olanzapine/fluoxetine capsule Versacloz Clozapine oral suspension Vraylar Cariprazine capsule Zyprexa/Zyprexa Zydis Olanzapine ODT, tablet Olanzapine ODT, tablet Anxiolytics Brand Name Generic Name Buspirone tablet Chlordiazepoxide capsule Clorazepate tablet Diazepam oral concentrate, solution, tablet Oxazepam capsule Ativan Lorazepam tablet, Intensol concentrate Lorazepam tablet, oral concentrate Lorazepam tablet Tranxene T-Tab Clorazepate tablet Clorazepate tablet Xanax/Xanax XR Alprazolam tablet/ER tablet Alprazolam tablet/ER tablet, ODT tablet Bile Salts Brand Name Generic Name Actigall Ursodiol capsule Ursodiol capsule Chenodal Chenodiol tablet Cholbam Cholic acid capsule Ocaliva Obeticholic acid tablet Urso/Urso Forte Ursodiol tablet Ursodiol tablet Calcitonin-Gene Receptor Protein (CGRP) Inhibitors Brand Name Generic Name Aimovig Erenumab-aooe auto-injector Ajovy Fremanezumab-vfrm auto-injector, syringe Emgality Galcanezumab-gnlm pen, syringe Nurtec ODT Rimegepant ODT tablet Ubrelvy Ubrogepant tablet Cardiovascular – Alpha-Blockers Brand Name Generic Name Minipress Prazosin capsule Prazosin capsule Cardiovascular – Beta-Blockers Brand Name Generic Name Single Agent Acebutolol capsule Betaxolol tablet Bisoprolol tablet Labetalol tablet Pindolol tablet Propranolol solution, tablet Timolol tablet Betapace Sotalol tablet Sotalol tablet Bystolic Nevibolol tablet Corgard Nadolol tablet Nadolol tablet Coreg Carvedilol tablet Carvedilol tablet Coreg CR Carvedilol ER capsule Carvedilol ER capsule Hemangeol Propranolol solution Inderal LA Propranolol ER capsule Propranolol ER capsule Inderal XL Propranolol ER capsule Innopran XL Propranolol ER capsule Kaspargo Metoprolol succinate sprinkle capsule Metoprolol tartrate tablet Lopressor Metoprolol tartrate tablet Metoprolol tartrate tablet Sotylize Sotalol solution Tenormin Atenolol tablet Atenolol tablet Toprol XL Metoprolol succinate tablet Metoprolol succinate tablet Combinations Metoprolol-HCTZ tablet Nadolol-Bendroflumethiazide tablet Propranolol-HCTZ tablet Tenoretic Atenolol-Chorthalidone tablet Atenolol-Chorthalidone tablet Ziac Bisoprolol-HCTZ tablet Bisoprolol-HCTZ tablet Cardiovascular – Calcium Channel Blockers Brand Name Generic Name Diltiazem ER capsule Felodipine ER tablet Isradipine capsule Nicardipine capsule Nimodipine capsule Verapamil tablet Adalat CC Nifedipine ER tablet Nifedipine ER tablet Calan SR Verapamil ER tablet Verapamil ER tablet Cardizem Diltiazem tablet Diltiazem tablet Cardizem CD Diltiazem ER capsule Diltiazem CD/ER capsule Cardizem LA Diltiazem ER/LA tablet Diltiazem ER/LA tablet Katerzia Amlodipine suspension Norvasc Amlodipine tablet Amlodipine tablet Nymalize Nimodipine solution, oral syringe Procardia Nifedipine capsule Nifedipine capsule Procardia XL Nifedipine ER tablet Nifedipine ER tablet Sular Nisoldipine ER tablet Nisoldipine ER tablet Tiazac ER Diltiazem ER capsule Diltiazem ER capsule Verelan/Verelan PM Verapamil ER pellet capsule Verapamil ER/ER PM capsule Diabetes Management - Insulins Brand Name Generic Name Rapid-acting Admelog Insulin lispro Solostar, vial Afrezza Insulin regular cartridge, unit Apidra Insulin glulisine Solostar, vial Fiasp Insulin aspart FlexTouch, penfill, vial Humalog/Humalog Jr. Insulin lispro cartridge, Kwikpen, vial Insulin lispro pen/Jr. pen, vial Lyumjev Insulin lispro-aabc Novolog Insulin aspart cartridge, Flexpen, vial Insulin aspart cartridge, pen, vial Short-acting Humulin R Regular insulin Kwikpen, vial Novolin R Regular insulin Kwikpen, vial Intermediate-acting Humulin N Insulin NPH Kiwkpen, vial Novolin N Insulin NPH Flexpen, vial Long-acting Basaglar Insulin glargine Kwikpen Lantus Insulin glargine Solostar, vial Levemir Insulin detemir Flextouch, vial Semglee Insulin glargine pen, vial Toujeo/Toujeo Max Insulin glargine Solostar Tresiba Insulin degludec Flextouch, vial Insulin Mixtures Humalog Mix 50/50 50% insulin lispro protamine/50% insulin lispro Kwikpen, vial Humalog Mix 75/25 75% insulin lispro protamine/25% insulin lispro Kwikpen, vial 75% insulin lispro protamine/25% insulin lispro Kwikpen, vial Humulin 70/30 70% insulin NPH/30% insulin regular Kwikpen, vial Novolin 70/30 70% insulin NPH/30% insulin regular Flexpen, vial Novolog Mix 70/30 70% insulin aspart protamine/30% insulin aspart Flexpen, vial 70% insulin aspart protamine/30% insulin aspart Flexpen, vial Glucagon, Self-Administered Brand Name Generic Name Baqsimi Glucagon spray Glucagen Hypokit Glucagon kit Glucagon Emergency Kit Glucagon kit Gvoke Glucagon Hypopen, syringe Growth Hormones Brand Name Generic Name Genotropin Somatropin cartridge, Miniquick pen Humatrope Somatropin cartridge, vial Norditropin Somatropin Flexpro pen Nutropin AQ Somatropin Nuspin injector Omnitrope Somatropin cartridge, vial Saizen Somatropin cartridge, vial Serostim Somatropin vial Zomacton Somatropin vial Zorbtive Somatropin vial Hemorrhoidal, Anorectal and Related Topical Anesthetic Agents Brand Name Generic Name Hydrocortisone-Pramoxine 1%-1% cream Lidocaine cream, ointment, topical solution Lidocaine-Hydrocortisone 3%-0.5% cream/cream kit (also), 3%-1% cream kit, 2%-2% cream kit Lidocaine-Hydrocortisone 3%-2.5% gel/gel kit, 2.8- 0.55% gel Lidocaine-Prilocaine cream Anusol-HC Hydrocortisone 2.5% cream Proctosol-HC Proctozone-HC Procto-Med HC Hydrocortisone 2.5% cream Colocort Hydrocortisone 100 mg/60 mL enema Cortenema Hydrocortisone 100 mg/60 mL enema Cortifoam Hydrocortisone acetate 10% aerosol Epifoam Hydrocortisone-Pramoxine foam Pliaglis Lidocaine-Tetracaine cream Proctofoam-HC Hydrocortisone-Pramoxine 1%-1% foam Procto-Pak Hydrocortisone 1% cream Hydrocortisone 1% cream Rectiv Nitroglycerin 0.4% ointment Synera Lidocaine-Tetracaine patch Immune Globulins Brand Name Generic Name Bivigam Immune Globulin IV solution Cutaquig Immune Globulin-hipp SC solution Cuvitru Immune Globulin SC solution Flebogamma Dif Immune Globulin IV solution Gammagard Immune Globulin SC solution Gammagard S/D Immune Globulin IV powder vial Gammaked Immune Globulin IV/SC solution Gammaplex Immune Globulin IV solution Gamunex-C Immune Globulin IV/SC solution Hizentra Immune Globulin SC solution syringe, vial Hyqvia Immune Globulin-Hyaluronidase SC kit/pack Octagam Immune Globulin
Load more

Recommended publications
  • (CD-P-PH/PHO) Report Classification/Justifica
    COMMITTEE OF EXPERTS ON THE CLASSIFICATION OF MEDICINES AS REGARDS THEIR SUPPLY (CD-P-PH/PHO) Report classification/justification of medicines belonging to the ATC group D07A (Corticosteroids, Plain) Table of Contents Page INTRODUCTION 4 DISCLAIMER 6 GLOSSARY OF TERMS USED IN THIS DOCUMENT 7 ACTIVE SUBSTANCES Methylprednisolone (ATC: D07AA01) 8 Hydrocortisone (ATC: D07AA02) 9 Prednisolone (ATC: D07AA03) 11 Clobetasone (ATC: D07AB01) 13 Hydrocortisone butyrate (ATC: D07AB02) 16 Flumetasone (ATC: D07AB03) 18 Fluocortin (ATC: D07AB04) 21 Fluperolone (ATC: D07AB05) 22 Fluorometholone (ATC: D07AB06) 23 Fluprednidene (ATC: D07AB07) 24 Desonide (ATC: D07AB08) 25 Triamcinolone (ATC: D07AB09) 27 Alclometasone (ATC: D07AB10) 29 Hydrocortisone buteprate (ATC: D07AB11) 31 Dexamethasone (ATC: D07AB19) 32 Clocortolone (ATC: D07AB21) 34 Combinations of Corticosteroids (ATC: D07AB30) 35 Betamethasone (ATC: D07AC01) 36 Fluclorolone (ATC: D07AC02) 39 Desoximetasone (ATC: D07AC03) 40 Fluocinolone Acetonide (ATC: D07AC04) 43 Fluocortolone (ATC: D07AC05) 46 2 Diflucortolone (ATC: D07AC06) 47 Fludroxycortide (ATC: D07AC07) 50 Fluocinonide (ATC: D07AC08) 51 Budesonide (ATC: D07AC09) 54 Diflorasone (ATC: D07AC10) 55 Amcinonide (ATC: D07AC11) 56 Halometasone (ATC: D07AC12) 57 Mometasone (ATC: D07AC13) 58 Methylprednisolone Aceponate (ATC: D07AC14) 62 Beclometasone (ATC: D07AC15) 65 Hydrocortisone Aceponate (ATC: D07AC16) 68 Fluticasone (ATC: D07AC17) 69 Prednicarbate (ATC: D07AC18) 73 Difluprednate (ATC: D07AC19) 76 Ulobetasol (ATC: D07AC21) 77 Clobetasol (ATC: D07AD01) 78 Halcinonide (ATC: D07AD02) 81 LIST OF AUTHORS 82 3 INTRODUCTION The availability of medicines with or without a medical prescription has implications on patient safety, accessibility of medicines to patients and responsible management of healthcare expenditure. The decision on prescription status and related supply conditions is a core competency of national health authorities.
    [Show full text]
  • Steroids Topical
    Steroids, Topical Therapeutic Class Review (TCR) September 18, 2020 No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, digital scanning, or via any information storage or retrieval system without the express written consent of Magellan Rx Management. All requests for permission should be mailed to: Magellan Rx Management Attention: Legal Department 6950 Columbia Gateway Drive Columbia, Maryland 21046 The materials contained herein represent the opinions of the collective authors and editors and should not be construed to be the official representation of any professional organization or group, any state Pharmacy and Therapeutics committee, any state Medicaid Agency, or any other clinical committee. This material is not intended to be relied upon as medical advice for specific medical cases and nothing contained herein should be relied upon by any patient, medical professional or layperson seeking information about a specific course of treatment for a specific medical condition. All readers of this material are responsible for independently obtaining medical advice and guidance from their own physician and/or other medical professional in regard to the best course of treatment for their specific medical condition. This publication, inclusive of all forms contained herein, is intended to be educational in nature and is intended to be used for informational purposes only. Send comments and suggestions to [email protected]. September
    [Show full text]
  • 30 Day Change Notice Effective Date
    30 Day Change Notice Effective Date: January 1st, 2021 NEW PREFERRED DRUGS THERAPEUTIC CLASS NO PA REQUIRED PREFERRED Central Nervous System (CNS) Agents: Anticonvulsants Clobazam (Generic of Onfi) Central Nervous System (CNS) Agents: Multiple Aubagio EndocrineSclerosis Agents: Osteoporosis-Bone Ossification Forteo Enhancers Gastrointestinal Agents: Anti-Emetics Bonjesta Genitourinary Agents: Benign Prostatic Hyperplasia Alfuzosin (Generic of Uroxatral) Dutasteride (Generic of Avodart) Genitourinary Agents: Electrolyte Depleter Agents Sevelamer (Generic of Renagel and Renvela) Infectious Disease Agents: Antibiotics-Macrolides Eryped Infectious Disease Agents: Antivirals-HIV Atazanavir Sulfate Oral Powder (Generic of Reyataz) Tivicay PD Infectious Disease Agents: Antibiotics-Tetracyclines Vibramycin Suspension (no PA Required for age 12 or under) Ophthalmic Agents: Antibiotics and Antibiotic -Steroid Neomycin/Polymyxin/Bacitracin/Hydrocortisone Ointment Combination Drops and Ointments Ophthalmic Agents: Glaucoma Agents Dorzolamide/Timolol (Generic of Cosopt PF) NEW CLINICAL PA REQUIRED “PREFERRED” DRUGS THERAPEUTIC CLASS CLINICAL PA REQUIRED PREFERRED Blood Formation, Coagulation, and Thrombosis Agents: Corifact Hemophilia Factors Immunomodulator Agents for Systemic Inflammatory Taltz Disease Immunomodulator Agents for Systemic Inflammatory Xeljanz 5mg Disease NEW STEP THERAPY REQUIRED “PREFERRED” THERAPEUTIC CLASS STEP THERAPY REQUIRED “PREFERRED” Central nervous System (CNS) Agents: Anti-Migraine, Aimovig Prophylaxis Treatment Ajovy
    [Show full text]
  • Active Pharmaceutical Ingredients
    Active Pharmaceutical Ingredients Catalog HPD-5E ® CREATING A HEALTHY WORLDTM Active Pharmaceutical Ingredients (APIs) Available for International Markets Human Pharmaceutical Department www.Pharmapex.net Catalog HPD-5E *Not all products referred to on this site are available in all countries and our products are subject to different regulatory requirements depending on the country of use. Consequently, certain sections of this site may be indicated as being intended only for users in specic countries. Some of the products may also be marketed under different trade names. You should not construe anything on this site as a promotion or solicitation for any product or for the use of any product that is not authorized by the laws and regulations of your country of residence. For inquiries about the availability of any specic product in your country, you may simply contact us at [email protected]. **Products currently covered by valid US Patents may be offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk. ©2016, Pharmapex USA, A member of Apex Group of Companies, All Rights Reserved. Toll-Free: 1.844.PHARMAPEX Fax: + 1.619.881.0035 ACTIVE PHARMACEUTICAL [email protected] CREATING A HEALTHY WORLD™ www.Pharmapex.net INGREDIENTS About Pharmapex’s Human Pharmaceuticals Department: Pharmapex’s Human Pharmaceuticals Department (HPD) is a leading source for high-quality Active Pharmaceutical Ingredients (APIs) and Finished Pharmaceutical Products (FPPs) in various markets across the globe. With an extensive product portfolio, our consortium of companies is dedicated to addressing and solving the most important medical needs of our time, including oncology (e.g., multiple myeloma and prostate cancer), neuroscience (e.g., schizophrenia, dementia and pain), infectious disease (e.g., HIV/AIDS, Hepatitis C and tuberculosis), and cardiovascular and metabolic diseases (e.g., diabetes).
    [Show full text]
  • Formulary Updates Effective January 1, 2021
    Formulary Updates Effective January 1, 2021 Dear Valued Client, Please see the following lists of formulary updates that will apply to the HometownRx Formulary effective January 1 st , 2021. As the competition among clinically similar products increases, our formulary strategy enables us to prefer safe, proven medication alternatives and lower costs without negatively impacting member choice or access. Please note: Not all drugs listed may be covered under your prescription drug benefit. Certain drugs may have specific restrictions or special copay requirements depending on your plan. The formulary alternatives listed are examples of selected alternatives that are on the formulary. Other alternatives may be available. Members on a medication that will no longer be covered may want to talk to their healthcare providers about other options. Medications that do not have alternatives will be available at 100% member coinsurance . Preferred to Non -Preferred Tier Drug Disease State /Drug Class Preferred Alternatives ALREX Eye inflammation loteprednol (generic for LOTEMAX) APRISO 1 Gastrointestinal agent mesalamine (generic for APRISO) BEPREVE Eye allergies azelastine (generic for OPTIVAR) CIPRODEX 1 Ear inflammation ciprofloxacin-dexamethasone (generic for CIPRODEX) COLCRYS 1 Gout colchicine (generic for COLCRYS) FIRST -LANSOPRAZOLE Gastrointestinal agent Over-the-counter lansoprazole without a prescription FIRST -MOUTHWASH BLM Mouth inflammation lidocaine 2% viscous solution (XYLOCAINE) LOTEMAX 1 Eye inflammation loteprednol etabonate (generic
    [Show full text]
  • INTEGRIS Formulary July 2017
    INTEGRIS Formulary July 2017 Foreword FORMULARY EXCLUDED THERAPEUTIC DRUG This document represents the efforts of the MedImpact Healthcare Systems THERAPEUTIC DRUGS CLASS Pharmacy and Therapeutics (P & T) and Formulary Committees to provide ALTERNATIVES physicians and pharmacists with a method to evaluate the safety, efficacy and cost- clindamycin/tretinoin, ACNE AGENTS, effectiveness of commercially available drug products. A structured approach to the VELTIN drug selection process is essential in ensuring continuing patient access to rational ZIANA TOPICAL drug therapies. The ultimate goal of the MedPerform Formulary is to provide a morphine sulfate ER process and framework to support the dynamic evolution of this document to guide tablets, oxycodone ANALGESICS, KADIAN prescribing decisions that reflect the most current clinical consensus associated ER, NUCYNTA, NARCOTICS with drug therapy decisions. NUCYNTA ER ANALGESICS, This is accomplished through the auspices of the MedImpact P & T and Formulary BELBUCA BUTRANS PATCH Committees. These committees meet quarterly and more often as warranted to NARCOTICS ensure clinical relevancy of the Formulary. To accommodate changes to this ABSTRAL, document, updates are made accessible as necessary. FENTORA, fentanyl citrate ANALGESICS, LAZANDA, lozenge NARCOTICS As you use this Formulary, you are encouraged to review the information and ONSOLIS, provide your input and comments to the MedImpact P & T and Formulary SUBSYS Committees. immediate-release GRALISE ANTICONVULSANTS The MedImpact P & T
    [Show full text]
  • Printed Formulary Catalog Basic
    Scripps Health Formulary July 2016 Foreword Pharmacy and Therapeutics Committee. MedImpact approves such multi- This document represents the efforts of the MedImpact Healthcare Systems source drugs for addition to the MAC list based on the following criteria: Pharmacy and Therapeutics (P & T) and Formulary Committees to provide physicians A multi-source drug product manufactured by at least one (1) nationally and pharmacists with a method to evaluate the safety, efficacy and cost-effectiveness marketed company. of commercially available drug products. A structured approach to the drug selection At least one (1) of the generic manufacturer’s products must have an “A” process is essential in ensuring continuing patient access to rational drug therapies. rating or the generic product has been determined to be unassociated with The ultimate goal of the Portfolio Formulary is to provide a process and framework to efficacy, safety or bioequivalency concerns by the MedImpact P & T support the dynamic evolution of this document to guide prescribing decisions that Committee. reflect the most current clinical consensus associated with drug therapy decisions. Drug product will be approved for generic substitution by the MedImpact P & T Committee. This is accomplished through the auspices of the MedImpact P & T and Formulary Committees. These committees meet quarterly and more often as warranted to ensure This list is reviewed and updated periodically based on the clinical literature and clinical relevancy of the Formulary. To accommodate changes to this document, pharmacokinetic characteristics of currently available versions of these drug updates are made accessible as necessary. products. As you use this Formulary, you are encouraged to review the information and provide If a member or physician requests a brand name product in lieu of an approved your input and comments to the MedImpact P & T and Formulary Committees.
    [Show full text]
  • United States Patent (19) 20
    United States Patent (19) 11 Patent Number: 5,043,165 Radhakrishnan (45) Date of Patent: "Aug. 27, 1991 (54) NOVELLIPOSOME COMPOSITION FOR (56) References Cited SUSTANED RELEASE OF STEROIDAL U.S. PATENT DOCUMENTS DRUGS 4,224,179 9/1980 Schneider ........................... 424/450 4,235,871 11/1980 Parahadjopoulos et al........ 424/450 (75) Inventor: Ramachandran Radhakrishnan, 4,515,736 5/1985 Deaner ................................... 424/9 Fremont, Calif. 4,693,999 9/1987 Axelsson et al. .................... 514/18O 4,746,516 5/1988 Moro et al. ........................... 514/36 73 Assignee: Liposome Technology, Inc., Menlo 4,780,455 10/1988 Lieberman et al. ................. 514/82 Park, Calif. Primary Examiner-Thurman K. Page Assistant Examiner-P. L. Prater * Notice: The portion of the term of this patent Attorney, Agent, or Firm-Hana Dolezalova subsequent to Mar. 6, 2007 has been (57 ABSTRACT disclaimed. This invention relates to a novel, non-conventional liposome formulation for the sustained release and de 21 Appl. No.: 284,216 livery of steroids. The formulation provides prolonged release of the drug, improved therapeutic ratio, lower (22 Filed: Dec. 14, 1988 toxicity, reduced systemic side effects and is stable for up to three months. The formulation is suitable for sus 51) Int. Cl............................................... A61K 37/22 tained delivery of steroid via inhalation, parenteral, 52 U.S. C. ..................................... 424/450; 424/1.1; intrathecal, intraarticular, topical, ophthalmic, and oral 424/9; 514/180 administration. 58) Field of Search ............................ 424/450, 9, 1.1; 514/180 43 Claims, 7 Drawing Sheets 5O OO E 5O N s 20 L to s CO 5 C - OL 2 O O.5 O 5 2.O 2.5 HOURS U.S.
    [Show full text]
  • Malta Medicines List April 08
    Defined Daily Doses Pharmacological Dispensing Active Ingredients Trade Name Dosage strength Dosage form ATC Code Comments (WHO) Classification Class Glucobay 50 50mg Alpha Glucosidase Inhibitor - Blood Acarbose Tablet 300mg A10BF01 PoM Glucose Lowering Glucobay 100 100mg Medicine Rantudil® Forte 60mg Capsule hard Anti-inflammatory and Acemetacine 0.12g anti rheumatic, non M01AB11 PoM steroidal Rantudil® Retard 90mg Slow release capsule Carbonic Anhydrase Inhibitor - Acetazolamide Diamox 250mg Tablet 750mg S01EC01 PoM Antiglaucoma Preparation Parasympatho- Powder and solvent for solution for mimetic - Acetylcholine Chloride Miovisin® 10mg/ml Refer to PIL S01EB09 PoM eye irrigation Antiglaucoma Preparation Acetylcysteine 200mg/ml Concentrate for solution for Acetylcysteine 200mg/ml Refer to PIL Antidote PoM Injection injection V03AB23 Zovirax™ Suspension 200mg/5ml Oral suspension Aciclovir Medovir 200 200mg Tablet Virucid 200 Zovirax® 200mg Dispersible film-coated tablets 4g Antiviral J05AB01 PoM Zovirax® 800mg Aciclovir Medovir 800 800mg Tablet Aciclovir Virucid 800 Virucid 400 400mg Tablet Aciclovir Merck 250mg Powder for solution for inj Immunovir® Zovirax® Cream PoM PoM Numark Cold Sore Cream 5% w/w (5g/100g)Cream Refer to PIL Antiviral D06BB03 Vitasorb Cold Sore OTC Cream Medovir PoM Neotigason® 10mg Acitretin Capsule 35mg Retinoid - Antipsoriatic D05BB02 PoM Neotigason® 25mg Acrivastine Benadryl® Allergy Relief 8mg Capsule 24mg Antihistamine R06AX18 OTC Carbomix 81.3%w/w Granules for oral suspension Antidiarrhoeal and Activated Charcoal
    [Show full text]
  • Index B Alphabetical List of Pharmaceutical Product Names
    INDEX B ALPHABETICAL LIST OF PHARMACEUTICAL PRODUCT NAMES PRODUCT NAME Page PRODUCT NAME Page 292 97 ACYCLOVIR 17 3TC (EDS) 14 ACYCLOVIR 17 5-AMINOSALICYLIC ACID (MESALAMINE) 170 " 18 ABACAVIR SO4 13 ADALAT XL 57 ABACAVIR SO4/LAMIVUDINE 13 ADALIMUMAB 220 ABACAVIR SO4/LAMIVUDINE/ZIDOVUDINE 13 ADAPALENE 206 ABATACEPT 220 ADCIRCA (EDS) 89 ABILIFY (EDS) 123 ADEFOVIR DIPIVOXIL 18 ACARBOSE 187 ADHESIVE WIPES (EDS) 239 ACCEL PIOGLITAZONE (EDS) 190 ADVAGRAF (EDS) 231 ACCEL TOPIRAMATE 112 ADVAIR (EDS) 33 ACCEL-CITALOPRAM 114 ADVAIR DISKUS (EDS) 33 ACCOLATE (EDS) 232 AGGRENOX (EDS) 87 ACCU-CHEK 1 MINI (EDS) 238 AGRYLIN 221 ACCU-CHEK 2 MINI (EDS) 238 AIROMIR 32 ACCU-CHEK ADVANTAGE 142 ALCOHOL PREP 234 ACCU-CHEK AVIVA 142 ALCOHOL SWAB 234 ACCU-CHEK COMPACT 142 ALDACTAZIDE-25 82 ACCU-CHEK FASTCLIX MOBILE 234 ALDACTAZIDE-50 82 ACCU-CHEK LINKASSIST (EDS) 239 ALDACTONE 148 ACCU-CHEK MOBILE 142 ALDARA (EDS) 209 ACCU-CHEK MULTICLIX 234 ALENDRONATE (EDS) 220 ACCU-CHEK RAPID D (EDS) 236 ALENDRONATE SODIUM 220 " 237 ALENDRONATE SODIUM (EDS) 220 " 238 ALENDRONATE SODIUM/VITAMIN D3 ACCU-CHEK SPIRIT (EDS) 236 (CHOLECALCIFEROL) 220 ACCU-CHEK TENDER 1 (EDS) 238 ALERTEC (EDS) 133 " 239 ALESSE 181 ACCU-CHEK TENDER 2 (EDS) 238 ALFACALCIDOL 217 " 239 ALFUZOSIN 220 ACCU-CHEK ULTRAFLEX 1 (EDS) 237 ALGLUCOSIDASE ALFA 221 " 238 ALLOPURINOL 221 ACCU-CHEK ULTRAFLEX 2 (EDS) 237 ALMOTRIPTAN MALATE 33 " 238 ALOMIDE 158 ACCUPRIL 79 ALPHAGAN 157 ACCURETIC 80 ALPHAGAN P 157 ACCUTANE 209 ALPRAZOLAM 134 ACCUTREND 142 ALPRAZOLAM 134 ACEBUTOLOL 48 ALTACE 80 ACEBUTOLOL HCL 48 " 81
    [Show full text]
  • Pharmacokinetics of Ophthalmic Corticosteroids
    British Journal ofOphthalmology 1992; 76: 681-684 681 MINI REVIEW Br J Ophthalmol: first published as 10.1136/bjo.76.11.681 on 1 November 1992. Downloaded from Pharmacokinetics of ophthalmic corticosteroids Corticosteroids have been used by ophthalmologists with an identical vehicle, the aqueous humour concentrations of increasing frequency over the past 30 years, with the these steroids are almost identical.'9 None the less it is concomitant development of a diverse range of drop, essential when considering such empirical data, to recall that ointment, subconjunctival, and oral preparations. Though the systemic anti-inflammatory effect of both betamethasone the clinical benefits and side effects of such corticosteroid and dexamethasone is five to seven times that of predniso- preparations have been well documented, their basic lone.39"' The local anti-inflammatory potency of ocular pharmacokinetics in the human eye have yet to be fully steroids has yet to be fully investigated and whilst early work established. Indeed most of our pharmacokinetic knowledge suggested that prednisolone acetate 1% had the greatest anti- of these drugs has been elucidated by extrapolation of data inflammatory effect in experimental keratitis,'7 later studies obtained from rabbit experiments.1-26 These results can be demonstrated that fluorometholone acetate in a 1% formu- significantly disparate from human data because of the lation was equally efficacious in the same model.26 However, thinner rabbit cornea, lower rabbit blink rate, effect of prednisolone
    [Show full text]
  • Teva Pharmaceutical Industries Ltd
    m n a d v s g o PRODUCT v1 2015 CATALOGUE h p b e q f i t w c l r z www.tapi.com PRODUCT CATALOGUE v1 2015 US CEP EU Japan Korea DMF DMF DMF DMF ABIRATERONE a ACYCLOVIR x x x AFATINIB ALCLOMETASONE DIPROPIONATE x x ALENDRONATE SODIUM x x x ALLOPURINOL x x x x AMCINONIDE x x x AMITRIPTYLINE HCL x x x x x AMLODIPINE BESYLATE x x x ANASTROZOLE x x x ANIDULAFUNGIN APIXABAN APREMILAST ARIPIPRAZOLE x x ARIPIPRAZOLE LAUROXIL ATORVASTATIN CALCIUM* x x x x ATOSIBAN ACETATE ATRACURIUM BESYLATE x x x AZACITIDINE x x AZITHROMYCIN x x x x AZTREONAM x BECLOMETHASONE DIPROPIONATE x x x x b BETAMETHASONE ACETATE x x x BETAMETHASONE BASE x x x BETAMETHASONE DIPROPIONATE x x x x BETAMETHASONE VALERATE x x x x BICALUTAMIDE x x BIMATOPROST x x BIVALIRUDIN x x BLEOMYCIN SULFATE x x BORTEZOMIB x x x * TAPI can provide several different polymorphs or processes of this product. To obtain complete DMF files of a specific product's polymorph or process, please contact your account manager. For the most updated product list please go to "Products" at www.tapi.com Additional DMFs or Tech Files are available upon request All subject to the disclaimer on page 15 PRODUCT CATALOGUE v1 2015 US CEP EU Japan Korea DMF DMF DMF DMF BROMOCRIPTINE MESYLATE x x b BUDESONIDE x x x x BUPRENORPHINE BASE x x BUPRENORPHINE HCL x x x BUTORPHANOL TARTRATE x x CABAZITAXEL x CABERGOLINE x x x x c CALCIPOTRIENE (CALCIPOTRIOL)* x x x CALCITRIOL x x x CANDESARTAN CILEXETIL x CAPECITABINE x x CARBIDOPA x x x x CARBOPLATIN x x x x CARFILZOMIB CARVEDILOL BASE x x x x x CARVEDILOL PHOSPHATE x CASPOFUNGIN ACETATE x x CERITINIB CHLORMADINONE ACETATE x x CICLOSPORIN x x x x x CILOSTAZOL x x x x CINACALCET HCL x x CISATRACURIUM BESYLATE x x CISPLATIN x x x CLARITHROMYCIN x x x x x CLOBETASOL PROPIONATE x x x x x CLONAZEPAM x CLOPIDOGREL BISULFATE x x x x CYPROTERONE ACETATE x x d DABIGATRAN ETEXILATE x DARIFENACIN HBR x x * TAPI can provide several different polymorphs or processes of this product.
    [Show full text]