Contents Volume 61 Issue 4 | April 2012

Impact factor: 10.614 528 Effects of haptoglobin polymorphisms and Commentaries deficiency on susceptibility to inflammatory 473 An alternative way for epithelial-to- bowel disease and on severity of murine colitis mesenchymal transition in colorectal cancer via L Márquez, C Shen, I Cleynen, G De Hertogh, EIF5A2? K Van Steen, K Machiels, C Perrier, V Ballet, F T Kolligs S Organe, M Ferrante, L Henckaerts, G Galicia, Gut: first published as on 1 April 2012. Downloaded from Caption: Tongue bacteria. Coloured scanning electron micrograph P Rutgeerts, J L Ceuppens, S Vermeire (SEM) of bacteria on the surface of a human tongue. Large numbers 474 Too much fat for the gut’s microbiota of bacteria can form a visible layer on the surface of the tongue. The mouth contains a large number of bacteria, most of which are H Tilg, J R Marchesi harmless or even beneficial. However, some bacteria can cause 535 Developing an instrument to assess the throat infections or cause the formation of plaque deposits on the teeth, which may lead to decay. Magnification: x10,000 at 10cm endoscopic severity of ulcerative colitis: the wide/STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY. Leading article Ulcerative Colitis Endoscopic Index of Severity An international journal of 476 Inflammatory bowel disease therapies and (UCEIS) cancer risk: where are we and where are we gastroenterology and hepatology S P L Travis, D Schnell, P Krzeski, M T Abreu, Editor going? D G Altman, J-F Colombel, B G Feagan, Emad El-Omar (UK) L Beaugerie Deputy Editor (Hepatology) S B Hanauer, M Lémann, G R Lichtenstein, Alexander Gerbes (Germany) Guidelines P R Marteau, W Reinisch, B E Sands, B R Yacyshyn, C A Bernhardt, J-Y Mary, Deputy Editor (Luminal 484 Guidelines for liver transplantation for patients W J Sandborn Gastroenterology) with non-alcoholic steatohepatitis William Grady (USA) P N Newsome, M E Allison, P A Andrews, Associate Editors Gut microbiota Matias Avila (Spain) G Auzinger, C P Day, J W Ferguson, 543 Metabolic adaptation to a high-fat diet is Guy Boeckxstaens (Belguim) P A Henriksen, S G Hubscher, H Manley, associated with a change in the gut microbiota Laurence Egan (Ireland) P J McKiernan, C Millson, D Mirza, M Serino, E Luche, S Gres, A Baylac, M Bergé, Thomas Gress (Germany) J M Neuberger, J Oben, S Pollard, K J Simpson, C Cenac, A Waget, P Klopp, J Iacovoni, C Klopp, Ernst Kuipers (The Netherlands) D Thorburn, J W Tomlinson, J S Wyatt J Mariette, O Bouchez, J Lluch, F Ouarné, Julian Panes (Spain) Herbert Tilg (Austria) P Monsan, P Valet, C Roques, J Amar, Fabien Zoulim (France) Original articles A Bouloumié, V Théodorou, R Burcelin Oesophagus http://gut.bmj.com/ Editorial Office Gut 501 Clinical, but not oesophageal pH-impedance, GI neoplasia BMJ Journals profiles predict response to proton pump 554 Generation of gaseous sulfur-containing BMA House, Tavistock Square inhibitors in gastro-oesophageal reflux disease compounds in tumour tissue and suppression of London, WC1H 9JR, UK F Zerbib, K Belhocine, M Simon, M Capdepont, gas diffusion as an antitumour treatment T: +44 (0)20 7383 6394 F Mion, S Bruley des Varannes, J-P Galmiche K Yamagishi, K Onuma, Y Chiba, S Yagi, F: +44 (0)20 7383 6668 S Aoki, T Sato, Y Sugawara, N Hosoya, Y Saeki, E: [email protected] on September 23, 2021 by guest. Protected copyright. Helicobacter pylori M Takahashi, M Fuji, T Ohsaka, T Okajima, ISSN: 0017-5749 (print) 507 Long-term clinical outcome of gastric MALT ISSN: 1468-3288 (online) K Akita, T Suzuki, P Senawongse, lymphoma after eradication of Helicobacter A Urushiyama, K Kawai, H Shoun, Y Ishii, Disclaimer: Gut is owned and published by BMJ pylori: a multicentre cohort follow-up study of Publishing Group Ltd, a wholly owned subsidiary of H Ishikawa, S Sugiyama, M Nakajima, the British Medical Association and the British 420 patients in Japan M Tsuboi, T Yamanaka Society of Gastroenterology. The owners grant editorial freedom to the Editor of Gut. Gut follows S Nakamura, T Sugiyama, T Matsumoto, guidelines on editorial independence produced by K Iijima, S Ono, M Tajika, A Tari, Y Kitadai, the World Association of Medical Editors and the code on good publication practice of the H Matsumoto, T Nagaya, T Kamoshida, Committee on Publication Ethics. N Watanabe, T Chiba, H Origasa, M Asaka, for Gut is intended for medical professionals and is provided without warranty, express or implied. the JAPAN GAST Study Group Statements in the Journal are the responsibility of their authors and advertisers and not authors’ institutions, the BMJ Publishing Group, the British GI bleeding < Society of Gastroenterology or the BMA unless MORE CONTENTS otherwise specified or determined by law. 514 Upper gastrointestinal haemorrhage and Acceptance of advertising does not imply deprivation: a nationwide cohort study of health endorsement. inequality in hospital admissions To the fullest extent permitted by law, the BMJ Publishing Group shall not be liable for any loss, C J Crooks, J West, T R Card injury or damage resulting from the use of Gut or any information in it whether based on contract, tort or otherwise. Readers are advised to verify any Inflammatory bowel disease information they choose to rely on. 521 The Manitoba Inflammatory Bowel Disease Copyright Ó 2012 BMJ Publishing Group Ltd and British Society of Gastroenterology. All rights Cohort Study: a prospective longitudinal reserved; no part of this publication may be evaluation of the use of complementary and reproduced, stored in a retrieval system or transmitted in any form or by any means, services and products electronic, mechanical, photocopying, recording or otherwise without prior permission P Rawsthorne, I Clara, L A Graff, K I Bernstein, Gut is published by BMJ Publishing Group Ltd, R Carr, J R Walker, J Ediger, L Rogala, N Miller, typeset by TNQ Books & Journals, Chennai, India and printed in the UK on acid-free paper from C N Bernstein sustainable forests by Latimer Trend & Co Ltd, Plymouth, UK Gut (ISSN: 0017-5749) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to Gut, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Contents Volume 61 Issue 4 | GUT April 2012

Colon 604 High-frequency vagus nerve stimulation 562 Overexpression of EIF5A2 promotes colorectal improves portal hypertension in cirrhotic rats carcinoma cell aggressiveness by upregulating I Bockx, K Verdrengh, I Vander Elst, J van Pelt, MTA1 through C-myc to induce F Nevens, W Laleman, D Cassiman epithelialemesenchymaltransition

W Zhu, M-Y Cai, Z-T Tong, S-S Dong, S-J Mai, Recent advances in basic science Gut: first published as on 1 April 2012. Downloaded from Y-J Liao, X-W Bian, M C Lin, H-F Kung, 613 Stem cell transplantation in neurodegenerative Y-X Zeng, X-Y Guan, D Xie disorders of the gastrointestinal tract: future or fiction? 576 Interval cancers in a FOBT-based colorectal S Kulkarni, L Becker, P J Pasricha cancer population screening programme: implications for stage, gender and tumour site Recent advances in clinical practice 622 Hospitalisations and surgery in Crohn’s disease R J C Steele, P McClements, C Watling, G Libby, C N Bernstein, E V Loftus Jr, S C Ng, D Weller, D H Brewster, R Black, F A Carey, P L Lakatos, B Moum, on behalf of the C G Fraser Epidemiology and Natural History Task Force of Pancreas the International Organization for the Study of 582 Variations of oral microbiota are associated Inflammatory Bowel Disease (IOIBD) with pancreatic diseases including pancreatic cancer JournalScan GI highlights from the literature J J Farrell, L Zhang, H Zhou, D Chia, D Elashoff, 630 D Akin, B J Paster, K Joshipura, D T W Wong PostScript Hepatology 632 Letters 589 Hepatitis C virus non-structural 3/4A protein 636 Correction interferes with intrahepatic interferon-g production Editor’s quiz: GI snapshot http://gut.bmj.com/ E D Brenndörfer, A Brass, J Söderholm, L Frelin, 513 Anaemia in a cardiopath S Aleman, J G Bode, M Sällberg G W Moran, A Brind

597 Chronic hepatitis E infection in children with liver transplantation

U Halac, K Béland, P Lapierre, N Patey, P Ward, on September 23, 2021 by guest. Protected copyright. J Brassard, A Houde, F Alvarez