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Parts I and II DOCUMENT RESPME ED 045 399 SF 010 121 TITLE Report on the Secretary's Commission on Pesticides and Their Pelationship to Environmental Health, Parts 1 and 2. INSTITUTION Department of Health , Education, and Welfare, Washington., D.C. Office of the Secretary. PUB DATE Dec 6Q NOTE 677p. AVAILABLE FRCM Superintendent of Pocuments, U.S. Government. Printing Office, Washington, D.C. 20402 (Cat. No. HE 1.2;P-43/Pt. 1,2, 4'3.00) ERRS PRICE EDRq Price MF-12.7 PC Not Available from EPPS. DESCRIPTORS Agriculture, Biology, *Environment, *Government Pole, Perbicides, Insecticides, *Medicine, *Pesticides, *Pollution, Public Health ABSTPACT The report recommends government actions that should he taken concerning (1)the coordination of information dissemination and research related to the< effects of pesticides;(2) the control or elimination of the use of specific persistent, pesticides in the United States, and the development of standards for the exposure of humans to insecticides in food, water, anc air; and(3) regulation and legislaticn concerning pesticide development, testing and use. These recommerlations are based on the extensive reviews of the literature included as Part 2 of tho report. The topics reviewed wore;(1) uses and benefits;(2) contamination;(1) effects on non-target organisms other than man; (4) effects on man; (5) carcinogenicity; (f) 3_nterraction (in target and non-target organisms) ; (7) mutagenicity; and (P)teratogenicitv (abnormalities of nre-natal origin). Pibliographies are included in each review. Peviews indicate needod research as well as available data. Possitle alternative means of pest control are considered in reviews 1,2, and Z. (AL) CN C' M Lt.% U S DEPARTKINT Of HEWN, EDUCATION I Wild 4. OfiKC Of EDUCATION C) THIS DOCUMENT MIS KIN RiPRODUCEDISICTER AS WAIVED FROM 114 CI PINSON OR ORGANIZATION ORIGINATING if.POINTS Of VIEW ON OPINIONS W STATED DO ROT NICESSAINT frIPHSITIT OFFICIAL OffiCf Of EDUCATION POSITION OR POilt,. Parts I and II ct 0146 40 U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Ditembet 1969 161.1 Report of the Secretary's Commission on Pesticides and Their Relationship to Environmental Health U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Deombet 1969 Fat WI by the %reinfection bt Doessents, .S. Government Printing Ocoee Wanbingtes. D.C. IOW blot WPC TABLE OF CONTENTS Pare Letter of Transmittal Acknowledgments Membership of the Commission vi Membership of the Commission Subcommittees viii Membership of the Advisory Panels ix Acknowledgements to Other Contributors _ aril Part I. Commission Recommendations on Pesticides 1 Letter of Transmittal 3 Introduction 6 Commission Recommendations Summaries of Subcommittee Reports 21 Part II. Subcommittee and Panel Reports 39 Chapter 1. Uses and Benefits 41 Chapter 2. Contamination 99 Chapter 3. Effects of Pesticides on Nontarget Organisms Other Than Men 177 Chapter 4. Effects of Pesticides on Man 229 Chapter 8. Carcinogenicity of Pesticides. 459 Chapter 6. Interactions 807 Chapter 7. Mutagenicity of Pesticides 868 Chapter 8. Teratogenicity of Pesticides 655 lit DEPARTMENT OF HEALTH, EDUCATION. AND WELFARE December 5, 1969 Dear Sr. Simretarys The complete report of your Commission on Pesticides -mad Thstr Relationship to Environmental Health (Part 16. Part 11) is included herein. Part I, which I submttted to you on November 11, 1969, contains the Commission's unanimous recommendations along with mummeries of the reports of four SubcoAettees to the Commission. Part II contains the complete reports and conclusions of four Subcommittees and the four Advisory Panels to the Commission. upon which findings the Commission based its recommAndations. Over 5000 references to published or ongoing scientific rose rch were reviewed and evalutted. Since each report was prepared by the membership of the Subcommittee Advisory Panel involved with the particular subject under .!eview, these reports t themselves do not necessarily reflect the unanimous opinion of the Commission's entire membership, although each Commission member has reviewed all drafts of all reports. However, the recommendations of the Commission were adopted unanimously. On behalf of the Commission, its entire staff, and speaking for myself, I would like to thank you for the superb support you and your Department have given to the Commission.Ws hops that our rec.-mendetions will be considered for early implementation by all Departments concerned with the use of pesticides. Sincerely yours, tail M. ?teak Chairman Secretary's Commission on Pesticides and their Relationship to Environmental Health Honorable Robert H. Pinch Secretary Department of Health, Education, and Welfare Washington, D. C. Enclosures V MEMBERSHIP OF THE COMMISSION Da. Emit M. Maarc---Ohatrrnan Chancellor Emerkus, University of California at Davis Da. W114.1.414 J. DAISY Vice Oho (rim OR Chairman, Department of Biochemistry, Vanderbilt University Dr. 11dsofs P. Alder Dr. haloto B. Johnson Vice President, Agricultural Research Director of Research and Development Dow Chemical Company Eli Lilly and Company Mrs. Virgin/0 lindner Dr. Lemma 0. Coto Special Assistant to the President for Consumer Affairs, The White House Professor and Chairman, Department ALTIMItAtePrInCLI McLewpMis, of Zoology Director, Producer Marketing Division of illotogicol Sciences, Relationships. President's Oorn- Cornell University mitee on Couturner interests Dr, Ellefle Crovfos Dr. Thomas 11. Milby DirectorandResearchProfessor, Chief, Bureau of Occupational Health Natural Resources institute and an EnvironmentalEpidemiology Chesapeake Biological Laboratory CaliforniaDepartmentofPublic University of Maryland Health Dr. Leos Gelber, Dr. Denier A. Oben Head. Department of Environmental Scientific Director, Research Profes- Sciences and Engineering sor of Pathology Institute of Experi- University of North Carolina mental Pathology and Toilcology Albany Medical College Dr. Dodd Pfracritel Head, Department of Entomology and Dr. Gordon Gorr Umnology Chairman. Department of Entomology State University of New York College Michigan Stale University of Agriculture, Oornell Prof. .11orlov P. ',Oben Dr. /A^orkti C. Strong' Department of Environmental Health, Director. Leonell C. Strong Research University of likhlgan Foundation lttrissediaralleleal time etallatote. vi Commission Staff Members Dr. Ammar C. KOLBYE, Jr., EaTeullee Secretary and Staff Director Special Assistant (for Standards and Compliance) to the Deputy Administrator, Consumer Protection and Environmental Health Service Dr. DALE R. LIND8AY, Special Assistant to the Cornea/Rion Associate Comm isstoner for Science, Food and Drug Administration Dr. Joni.; E. DAVIES, Special Asestant to the Commission Community Studies on Pesticides, Dade County Departn. mt of Public Health, Fla. Mr. W. WADE TALBOT, Frees fire Officer Chief, Laboratory Services Branch, Bureau of Science Food and Drug Administration Mr. litasciir.t. F. Cumszn Inventions Adviser, Health Services and Mental Health Administration Mr. IRVIN° GERUND Executive Secretary, Special Study Sect lone Division of Research Grants, National Institutes of Health DT. TFIOUAB W. Mince Office of Grants Management, Public Health Service V.8. l)eparttr,ent of Health, Education, and Welfare, Re.n IV :dr. Roarsr R. Itionvicit, Previous .1:cewtivc Offleer, Secretary's Commission on 11(.811(1(1es Executive Officer, Environmental Control Administration Dr. Ron S. McCutentox Executive Secretary, Toxicology Study Sect ion Division of Research Grants, National Institutes of Health Dr. 0. FiVEROL'Offg HIDE* Acting Deputy Director. National Library of Medicine Mr. ',ram L. RAMSEY Assistant Director for Regulatory Programs Bureau of Science, Food and Drug Administration Mr. J. STVART Rlctt Printing Officer, Social Security Administration Mr. JAUES 0. TERBILL, Jr. Special Assistant to the Administrator Consumer Protection and Environmental Health Service Dr. WI UL/A14 M. l'PlIOLT Executive Secretary. Federal Commit lee on Pest Control Food and Drug Administration Dr. I !snow W. Was. Director. Dillsicm of Criteria and Standards, Bureau of Water Hygiene Environmental Control Administration vii MEMBERSHIP OF THE COMMISSION SUBCOMMITTEES Subcommittee on Uses and Benefits of Pesticides Dr. Gordon E. Older, Chairman Dr. Lamont O. Cole Dr. Edwin F. Alder Dr. Thomas W. Haloes, Slag Subcommittee on Contamination Dr. Daniel A. Okun, Chairman Dr. Harold W. Wolf, Staff Professor Morton 8. Hulbert Subcommittee on the Meats of Pesticides on Nontarget Organisms Other Than Man Dr. IA Eugene emnlo, OMirstos Dr. David Mantel Dr. Julius K Johnson Dr. William H. Upholl, Aloft Subcommittee on Effects of Pesticides on Man Dr. Leon Golberg, Ohairmsa Dr. John E. Darks Dr. Thomas H.mut, Hr. James G. Vert II, Jr., Staff Subcommittee on Criteria and Recommendations Dr. William J. Debi, Chairman Dr. Leonel°. Strong Mrs. Virginia Knauer Mr. teasel IA Ramsey, Sid, Mr. Francis MetanghlisAltercate viii MEMBERSHIP OF THE ADVISORY PANELS Advisory Panel on Carcinogenicity of Pesticides Dr. William J. Darby, Marmon Dr. Paul Kotin Chairman, 1)epartment of Director, National Institute of Biochemistry Environmental Health Sciences Vanderbilt University School of Medicine Dr. James A. Miller Professor, Department of Oncology, Dr. Ian A. Mitchell, Panel Emotive University of Wisconsin Secretory Assistant Director, National Cancer Dr. Norton Nelson Institute Director, Institute of Environmental Medicine Dr. Harry P. Burchfield New York University I)itcctor, Division of Biological Center Sciences Half South
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