PENN Issue #11 Psychiatry Perspective

Spring 2012 PENN Issue #11 Psychiatry Perspective

THE DEPARTMENT OF PSYCHIATRY’S NEUROPSYCHIATRIC SIGNALING PROGRAM: Seeking New Research Paradigms for In This Issue Studies of Psychiatric Illnesses

COVER STORY Neuropsychiatric Signaling ecent years have seen tremendous progress in understanding the biological Program ...... 1 “Rmechanisms of psychiatric illnesses,” says Associate Professor Chang-Gyu Hahn, MD, PhD, who co-directs the Department of Psychiatry’s Neuropsychiatric Sig- CHAIRMAN’S REPORT ...... 2 naling Program (NPSP) with Assistant Professor Karin Borgmann-Winter, MD. “As we PROGRAM HIGHLIGHTS witness burgeoning information in Hall Mercer Wellness Fairs . . . .3 molecular and cellular biology Professionalism Program ...... 4 derived from animal and/or in vitro OUR DISTINGUISHED FACULTY studies, an important question is Awards and Honors ...... 7 how to relate these findings to clini- News & Goings On ...... 15 Research News ...... 21 cally relevant issues.” Research Grants ...... 26 Closing the gap between basic sci- Our Department in the News . .31 ence discovery and translation into New Faculty ...... 36 improved understanding and treat- CORNERSTONES ment of psychiatric illnesses is an Faculty Spotlight ...... 38 ultimate goal of the NPSP. Program Voluntary Faculty Profile . . . . .42 researchers focus on signal trans- Employee Snapshot ...... 44 duction, a fundamental biological EDUCATIONAL HIGHLIGHTS mechanism by which molecules initiate or retard interactions within and between Residents’ Corner ...... 46 cells. It is the window through which Drs. Hahn and Borgmann-Winter view psychi- Class of 2015 ...... 47 atric illness, particularly bipolar disorder and schizophrenia.

Investigating signaling mechanisms requires access to tissue samples, and selecting the optimal tissues to study brain diseases is critical. Because living human brain tissue is not accessible for experimentation, scientists must devise creative solutions to investigate biological processes that occur within the brain, and this is the focus of Up-to-date information on the NPSP. “We have a special interest in developing new study paradigms, which Departmental Events are include studies in the olfactory epithelium and biochemical and molecular methods available on the that can be applied to animal models and human post-mortem tissues,” says Dr. Department’s website Hahn. (www.med.upenn.edu/psych) One of Dr. Hahn’s and Dr. Borgmann-Winter’s scientific contributions has been to develop and establish a prototype for using tissues of the olfactory neuroepithelium to trace the course of psychiatric disease. The olfactory neuroepithelium is part of the neural system in humans for detecting odors. It is found in the nose and is accessible for obtaining tissue samples, unlike the human brain.

Department of Psychiatry Besides easy availability, the olfactory epithelium offers other advantages to and researchers. The olfactory epithelium contains neurons of various developmental Penn Behavioral Health University of Pennsylvania Continued on page 5 PAGE 2 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Chairman’s Report

012 is a milestone year in the history of our profession and Reese, Professor of Medical 2Department. It is the bicentennial year of the beginning of Jurisprudence and Toxicology, academic psychiatry in America here at Penn, and the 100th became the first Penn faculty anniversary of the official formation of the Department of Psy- member to lead an explicitly chiatry at the University of Pennsylvania. named program on “mental diseases.” Reese was followed by Looking back every now and then helps us appreciate our line- Charles K. Mills, who developed age, and encourages our efforts to take our places in a proud an interest in mental diseases in succession of world-acclaimed educators, scholars, and clini- the 1880s, supplementing his cians. 2012 reminds us of the extraordinary privilege it is to be interest in neurology. Mills at an institution where – over centuries – so many have con- wrote about the neurological tributed so much to our Department’s rich tradition, and to the aspects of the “criminally discipline of psychiatry. insane” and participated in the The image of Benjamin Rush adorns the cover of our Depart- post-mortem examination in ment’s newsletter, and the story of psychiatry at Penn – and in 1882 of Charles Guiteau, Presi- America itself – begins with him. In 1769, Rush returned from dent James Garfield’s assassin. his medical training in Edinburgh, Scotland to accept appoint- Tying back to Rush and forward to our Department today, both ment as America’s first Chair of Chemistry in the medical facul- Reese and Mills treated alcoholism and drug addiction. ty at the College of Philadelphia, later the University of Mills was professor of mental diseases and medical jurispru- Pennsylvania. He thus became one of the earliest teachers in the dence until 1901. He was succeeded by Charles W. Burr, also a nation’s first medical school, formed only four years before in distinguished neurologist, who was appointed Penn’s first 1765. Rush was a “man for all seasons,” gaining fame as a great Chair of Mental Diseases. According to medical school histori- physician, eloquent lecturer, prolific scholar, Dean of the Penn an George Corner (Two Centuries of Medicine: A History of the medical school, philanthropist, and signer of the Declaration of School of Medicine, University of Pennsylvania, 1965), this appoint- Independence, among many other pursuits. ment “marked the University of Pennsylvania’s recognition of Rush was also the world’s leading expert on mental diseases in psychiatry as a separate discipline.” In 1912, a full century after the late eighteenth and early nineteenth centuries. According to the publication of Rush’s seminal work, the Department of Psy- historians David Cooper and Marshall Ledger (Innovation and chiatry was formally established under Burr’s leadership. Tradition at the University of Pennsylvania School of Medicine: An In many respects, the success of our Department since its offi- Anecdotal Journey, 1990), Rush joined the staff of Pennsylvania cial formation is even more impressive than what came before. Hospital in 1783 and soon became interested in the two dozen Many of psychiatry’s most distinguished luminaries have mentally ill patients residing there. He worked to improve their passed through our halls over the past century. Many are work- physical environment, successfully organizing the effort to ing in the Department today and have been featured in the build a ward for them at the hospital in the 1790’s, and he stud- pages of this newsletter. I’m confident that we have more than ied the patients intensively. held our own over the past 100 years. Granted, competing In 1812, only a year before his death, Rush’s long period of against a signer of the Declaration of Independence who found- observation and reflection culminated in his Medical Inquiries ed the study of mental illness in America is a tall challenge, but and Observations Upon Diseases of the Mind, the first American it’s one we aspire to. As we enter the third century of psychia- textbook of psychiatry. This volume, which offered new try at Penn, let’s redouble our efforts to educate the next gener- approaches for treating the mentally ill, forever identified him ation of psychiatrists, conduct discovery research on the the as the “Father of American Psychiatry” and Penn as the “Birth- causes, prevention, and treatment of mental illness, and care for place of American Psychiatry.” Interestingly, too, Rush staunch- those who suffer from these diseases and disorders. ly opposed excessive alcohol consumption and proposed new ways to treat this addiction, a topical link to one of our Depart- ment’s current strengths. From this momentous peak, however, the study and treatment of mental illness, and the instruction of students in the discipline, meandered at Penn and elsewhere for most of the nineteenth century. Penn medical students were instructed in Dwight L. Evans, MD psychiatry primarily through lectures. They did see some Ruth Meltzer Professor and Chair patients at Pennsylvania Hospital and, after 1841, at the mental Professor of Psychiatry, Medicine and Neuroscience hospital (“insane asylum”) located nearby in West Philadelphia, but exposure to psychiatry was limited and not a focus at Penn or elsewhere. Not until the 1880’s did the study of mental illness begin to To view recent Chairman Reports on-line, please visit: assume a prominent place in the institution. In 1883, John J. http://www.med.upenn.edu/psych/chair.html

www.med.upenn.edu/psych PAGE 3 www.med.upenn.edu/psych

Program Highlights

HALL MERCER’S 2010 AND 2011 HEALTH AND WELLNESS FAIRS: MAKING THE LINK BETWEEN PHYSICAL AND MENTAL HEALTH ong known for the high quality is not enough,” Hall Mercer and Lof its community-centered the Health and Wellness Commit- behavioral health programs, the tee are committed to helping peo- Hall Mercer Community Behav- ple with mental illness enjoy full ioral Health Center at Pennsylva- and healthy lives. The Fairs are the nia Hospital sponsored important Committee’s first major functions, public health outreach events on and it is already well on the way to October 21, 2010 and April 21, developing additional wellness ini- 2011. tiatives in the areas of nutrition, exercise, complementary and alter- Hall Mercer’s 2010 and 2011 native therapies, and health educa- Health and Wellness Fairs attract- Earl Lounsberry, RN, checks the blood tion. ed a diverse group of senior citi- pressure of Security Officer Earl Williams. Hall Mercer is convinced that by zens, children, patients, providers, Refreshments, raffles, and door working with the whole person in and Pennsylvania Hospital staff prizes made the Fairs fun events, members. Many attendees had the but with a serious purpose. The opportunity to have their blood health screenings, demonstrations, pressure checked, learn about car- and information collectively diovascular health, observe breast emphasized that healthy living self-exam demonstrations conduct- requires both good physical and mental health. Science has shown that the two reinforce each other, and that a deficiency in either may profoundly impact the other. This connection was shown most dra- matically in a 2006 study docu- Robyn Smith, LSW, therapist, and Amira menting that individuals with Sedki, LSW, clinician, show off health serious mental illnesses (SMIs) – snacks at the Food and Nutrition Table. schizophrenia and major depres- Both are from Hall Mercer’s Home-School sive, bipolar, psychotic, and atten- Connection, which provides behavioral Donna Lee Wood, a Hall Mercer case manager, therapy to children in kindergarten instructs therapist Ingrid Chung in the proper tion deficit/hyperactivity through the 4th grade who are exhibiting way to spin yarn. Knitting has been shown to disorders – may die two or more behavioral problems in the classroom. lower blood pressure and may help with stress decades earlier than people not suf- reduction. the context of their lives, not just fering from such diseases.1 The their illnesses, the mortality gap official causes of these premature between those suffering from ed with a handheld model, eat deaths were not the SMIs per se, major mental illnesses and those healthy snacks, and receive ten- but medical illnesses also found in who are not can be eliminated. The sion-reducing chair massages. the general population, such as 2010 and 2011 Health and Well- Attendees also received valuable heart disease, cancer, and cere- information about food and nutri- ness Fairs were one step in reach- brovascular, respiratory, and lung tion (including childhood nutri- diseases. The result is a devastating that significant goal. tion), dental hygiene, urban ing comorbid relationship between gardening, and knitting and spin- medical and mental illnesses. 1 ning, aimed at lowering blood Colton CW, Manderscheid RW. Congruencies in increased mortality rates, years of potential life lost, and causes of pressure and lessening stress. Believing that “two-thirds of a life death among public mental health clients in eight states. Prev Chronic Dis 3(2):A42, 2006.

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 4 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

LAUNCH OF THE PROFESSIONALISM PROGRAM AT PENN MEDICINE

enn Behavioral Health (PBH) has friendly and highly effective solu- Based on the assessment and evalua- just launched a unique and inno- tion.” tion, PPPM offers training resources P to maintain improved physician per- vative program to help physicians PPPM is geared to move quickly formance. PPPM may recommend become better professionals. Called when problems arise. Clinical Direc- continuing education, brief and/or the Professionalism Program at Penn tor Foster is available for a telephone ongoing counseling, leadership train- Medicine (PPPM), this new initiative consultation within two business offers consultations and, if needed, ing and coaching, and/or other targeted interventions to improve resources designed to help physi- physician performance and foster cians achieve and maintain improved professionalism. PPPM works with “The program is performance. health care institutions and directly highly unique because it In some situations, continuing educa- with individual physicians to create a is customized case by tion, leadership training, and work- “culture of professionalism” in the case and initiated quick- shops are also needed for staff or workplace. administration working with the ly and effectively,” says How well physicians comport them- physicians. PPPM is prepared to selves with patients, staff, and their Dr. Foster. “By using offer management consultations and colleagues defines their professional- behavioral health executive coaching and/or other ism. When these relationships go resources designed to achieve and awry, patient safety, outcomes, and experts to manage inter- maintain improved performance. satisfaction suffer, and workplace ventions, assessing and Much of this service will be delivered morale erodes. PPPM is specifically ‘right-sizing’ the issues by Rosellen Taraborrelli, Executive designed to create the professional, Director of the program, and her collaborative, and collegial working at hand are accom- team. environment required to ensure that plished with unparal- No other program in the Delaware clinical care is delivered in an opti- leled efficiency.” Valley approaches professionalism mal manner and setting. interventions as PPPM. “The pro- PPPM grew out of work initiated gram is highly unique because it is under PBH’s Employee Assistance customized case by case and initiated quickly and effectively,” says Dr. Program, which developed into a days of any incident or conflict. Her Foster. “By using behavioral health program successfully implemented preliminary assessment forms the experts to manage interventions, by Jody Foster, MD for Penn Medi- basis for an immediate action plan. If assessing and ‘right-sizing’ the issues cine. This service has been used needed, a face-to-face meeting is at hand are accomplished with widely over the last few years by scheduled between Dr. Foster and unparalleled efficiency.” PPPM’s many Department Chairs across the the referring medical leadership team overriding objective is to help physi- University of Pennsylvania Health and then, as needed, with the physicians needing assistance to rebuild System who have referred physicians cian concerned. to the program. professional ties with patients, staff, PPPM has the capacity to follow up and colleagues and to preserve and PPPM is timely. “The issue of physi- with longer-term involvement. Based nurture those relationships in the cian behavior and professionalism in on the results of the initial action future. the workplace has gained national plan, an extended action plan may be attention,” says PPPM Clinical Direc- developed, including further evalua- For those wishing to learn more about the tor Foster. “Recently, the Joint Com- tion of the physician. Elements of this services of the Professionalism Program at mission, which is charged with longer intervention include individu- Penn Medicine (PPPM), please contact evaluating and accrediting health alized evaluations, structured and Rosellen Taraborrelli (423 Guardian Drive, 3 Blockley Hall Philadelphia, PA care organizations in the U.S., man- semi-structured psychological tests dated that all hospitals have ‘disrup- 19104) at (215) 662-7677 or email at for clarification, collateral interviews [email protected]. You may also tive medical staff’ policies and modes with involved staff, and distribution obtain additional information by visiting of intervention. As hospitals and and evaluation of 360-degree sur- the PPPM website at health systems struggle to meet this veys. www.med.upenn.edu/professionalism. mandate, the PPPM can be a user-

www.med.upenn.edu/psych PAGE 5 www.med.upenn.edu/psych

NEUROPSYCHIATRIC SIGNALING PROGRAM Continued from page 1

stages. It also has pluripotent cells, been shown in several psychiatric addressed one molecule or one stem cells capable of regenerating, illnesses, including schizophrenia. pathway at a time.” At this point, which can be propagated in vitro. Working as a team with Bruce I. Drs. Hahn and Borgmann-Winter These neurons and neural cells Turetsky, MD, Paul J. Moberg, PhD, are identifying the particular molec- and Raquel E. Gur, MD, PhD in the ular and cellular processes and net- therefore can be examined under in Department’s Neuropsychiatry Sec- works in the olfactory system, which vitro and ex vivo conditions, and are tion, Drs. Hahn and Borgmann-Win- have parallels in the brain. thus readily amenable to scientific ter are studying molecular and study. cellular underpinnings for olfactory Ultimately, the goal of the NPSP is dysfunction in this devastating dis- to tie studies back to human biolo- “The olfactory biopsy approach per- ease. gy. Program investigators are now mits us to capture neurons at specific stages of the illnesses,” Dr. Hahn explains, thus permitting “There are numerous molecules and biological researchers to study molecular and processes in the brain and in the nose, so findings in cellular characteristics linked to the trait of the illness or to specific states the nose can’t automatically be generalized to the of the illness. “In addition,” Dr. brain,” Dr. Hahn explains. “Our understanding at Hahn emphasizes, “we examine treatment-induced molecular and this point is that some of intracellular molecular cellular changes in patients by events in the brain are recapitulated in the olfactory obtaining tissues before and after treatment.” By examining tissues receptor neurons.” easily obtained from the nasal cavity, scientists hope to be able to esti- conducting studies to compare the mate how a psychiatric disease Olfactory epithelium tissue also biology of olfactory neurons of affecting the brain is progressing, offers great potential for learning human patients with that of mon- and track the path of treatment. how olfactory neuronal biology keys under similar behavioral or compares to that of the brain. Do pharmacological paradigms. The One emerging line of investigation neural cells taken from the nasal noses of humans are rather different from this approach is to examine cavity act in similar ways as brain from that of rodents, but Dr. molecular mechanisms linked to the cells? Can these readily accessible Borgmann-Winter has recently therapeutic efficacy of lithium, used tissues tell us what may be happen- shown that the olfactory epithelium for many years for the treatment of ing in the far less accessible human of monkeys is very much similar to bipolar disorder. Decades of studies brain? To answer this, the Hahn and that of humans, a good reason to have identified many molecular Borgmann-Winter labs are now con- study monkey biology to learn more events regulated by lithium. “For ducting olfactory biopsies from non- about human biology. the first time,” says Dr. Hahn, “we human primates (e.g., monkeys) in are able to examine which of these an effort to correlate the biology of Drs. Hahn and Borgmann-Winter are modulated in patients who olfactory neurons to that of brain tis- are also developing research para- respond to lithium therapy as sues of the same animals. digms to examine neurodevelop- opposed to the ones who are resist- mental aspects of major psychiatric ant. Recently we identified an “There are numerous molecules and illnesses. Here, they are utilizing altered signaling mechanism in the biological processes in the brain and rodent, non-human primate, and olfactory neural cells of patients in the nose, so findings in the nose human olfactory tissues for investi- with bipolar disorder.” “Interesting- can’t automatically be generalized to gations of disease pathophysiology ly,” Dr. Hahn says, “treatment of the brain,” Dr. Hahn explains. “Our in young animals and of neurode- these cells with lithium reversed understanding at this point is that velopmental effects of psychotropic these changes in cells derived from some of intracellular molecular medications. patients, while it did not in cell lines events in the brain are recapitulated of healthy subjects.” in the olfactory receptor neurons.” While animal models and olfactory However, he underlines that “it epithelial tissues from humans pro- Neural cells in the olfactory epitheli- would be incorrect to think that vide indirect windows into psychi- um are also proving useful for nose cells are the brain cells. Know- atric disease, postmortem human studying schizophrenia. Olfactory ing that it is not the case is where brain tissue offers a direct look. “A dysfunction, such as decreased abili- the real science starts. In other fundamental gap in neuropsychi- ty to distinguish between odors and words, the similarities between the atric research, compared to other detect and remember odors, has nose and the brain should be medical illnesses,” Dr. Hahn Continued on page 6

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 6 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 5 explains, “is that we do not have to think that molecular events under- Jiang Xu, MS and Johannes Reisert, access to the tissues of living patients. lying signaling consist of the ones PhD. Also important for the NPSP is Postmortem brain tissues offer that are linked in tandem. Increasing the collaboration with researchers at opportunities to study brains of evidence, however, is that there are Wake Forest University - Carol Shive- patients but only after death, and multiple cascades that are activated ly, PhD, Scott Hemby, PhD, and Jay thus the available tissues represent simultaneously and thus linear Kaplan, PhD - as well as the one with the biology of the patients at the time assessment of pathways may not cap- Alan Brown, MD and Andrew of death.” ture the complexity.” To explore this, Dwork, MD at Columbia University. Drs. Hahn and Borgmann-Winter “Postmortem brain tissues are of have recently developed mass-spec- Even the most exciting and innova- great importance as they may harbor trometer-based paradigms to assess tive work at the molecular and cellu- biological fingerprints of psychiatric hundreds of proteins in a lar levels may take years to influence illnesses,” says Dr. Hahn. “Over microdomain-specific fashion, as well patient care. When asked whether decades, research paradigms have as interactions among the proteins, their research has reached a point been limited to the assessment of stat- by examining postmortem brain tis- where it is even possible to speculate ic parameters, such as the amount of sues. on a timeframe for potential thera- proteins or RNAs. We have devel- peutic impact, Dr. Hahn responds, oped a number of study paradigms, The Neuropsychiatric Signaling Pro- “As excited as we are about our which now permit us to study how gram is highly collaborative. Drs. recent progress, cautious optimism the molecules are distributed in spe- Hahn and Borgmann-Winter recog- may be as far as critical evaluation of cific microdomains [subregions with- nize a decade-long collaboration with current science permits us to go. We in a cell] in postmortem brains and Nancy E. Rawson, PhD at the Monell have some ways to go.” That is reali- how signaling mechanisms are acti- Chemical Senses Center and AFB ty in the complex and uncertain vated, particularly in the context of International, critical to the establish- world of fundamental research, one protein-protein interactions.” ment of the olfactory neuroepithelial in which Drs. Hahn and Borgmann- biopsy as a research paradigm for Winter are using multiple innovative Historically, molecular interactions psychiatric illnesses. In addition, the approaches to increase our under- within cells have been examined NPSP interacts with scientists cur- standing of the basic mechanisms of from a linear perspective. “In other rently at the Monell Chemical Senses psychiatric illnesses and their treat- words,” Dr. Hahn clarifies, “we tend Center, including Karen K. Yee, PhD, ments.

2011 Department of Psychiatry Holiday Party

Inn at Penn

December 16, 2011

www.med.upenn.edu/psych PAGE 7 www.med.upenn.edu/psych

Our Distinguished Faculty

AWARDS & HONORS

PENN HONORS Robert I. Berkowitz, MD received the Patricia Lipschutz Distinguished Clinician Award from Department of Psychiatry Honors the Center for Weight and Eating Disorders in the Department of Psychiatry in December The Albert Stunkard Faculty Recognition Award is given 2011. The award is named for Patti Lipschutz, annually to faculty members who are outstanding teachers MSN, a psychiatric clinical nurse specialist, and mentors. The graduating resident class selects award who worked at the Center as a clinician and senior research winners who have significantly influenced their education coordinator before her death in 2009. and training. Named for Albert J. Stunkard, MD, Emeritus Professor of Psychiatry and former Chair of the Department, Donovan Maust, MD and Christopher Tjoa, MD received this award recognizes Dr. Stunkard's enormous contribution the 2011 Dr. Henry P. and M. Page Durkee Laughlin Foun- to the education, training, and support of Department hous- dation Award. Upon the recommendation of the residency estaff. David Weiss, MD, John P. O’Reardon, MD, Claudia program, this award is given to residents in recognition of Baldassano, MD, Christian Kohler, MD, and Benjamin R. their professional achievement, dedication, and scholarship Nordstrom, MD received this honor in 2011. throughout residency training. Founded in 1964 through the generosity of Hank and Page Laughlin, the Dr. Henry P. The 2011 PGY-3 & 4 Teaching Award was awarded to and M. Page Durkee Laughlin Foundation is based in Fred- Mahendra T. Bhati, MD and the 2011 PGY-1 & 2 Teaching erick, Maryland. For more than thirty years, the Laughlin Award was awarded to Paul Kettl, MD. These awards Foundation has honored outstanding residents in psychi- honor those individuals whom the residents believe were atric training programs throughout the United States and the most effective teachers of the academic year and exem- the United Kingdom. plary in shaping their overall education. Lauren Elliott, MD and Samuel Collier, MD were the 2011 Jacques P. Barber, PhD was awarded the 2011 Martin P. recipients of the Psychodynamic Psychotherapy Award Szuba Award for Excellence in Clinical Teaching and given by the Psychoanalytic Cluster Steering Committee. Research. This award is presented annually to a Department This award honors graduating residents in recognition of faculty member with outstanding teaching abilities, ongoing their excellence in providing psychodynamic psychothera- clinical research, and a focus on translating research con- py. cepts into clinically useful teaching, all of which Dr. Szuba embodied in his work.

Luciano Lizzi, MD, JD received the 2011 Annual Award for Clinical Faculty. This award, funded by a clinical faculty Child and Adolescent Psychiatry Teaching member, is given to a volunteer clinical faculty member Awards who has demonstrated long-term loyalty to the Department and excellence in teaching and/or supervising. These teaching awards from the Child and Adolescent Psy- chiatry Fellows (Class of 2011) at Children’s Hospital of Claudia Baldassano, MD was the recipient of Philadelphia honor faculty members whom the fellows the 2011 Earl Bond Award. Initiated by the regard as the most effective teachers of this academic year. efforts of Dr. William Peltz, this annual award The winners of each of these awards are recognized for their is given to a Department member who has dis- outstanding contributions as teachers and mentors. tinguished himself/herself for teaching at the • Karin Borgmann-Winter, MD received the Elizabeth B. medical student, resident and/or graduate levels. Weller Distinguished Teacher Award. • Marion Lindblad Goldberg, PhD received the Fellow George E. Woody, MD received the 2011 Scott Mackler Teaching Award for Outside Faculty. Award for Excellence in Substance Abuse Teaching. This • Martin E. Franklin, PhD received the Fellow Teaching award is given by the Penn/VA Center for Studies of Award for In-House Faculty. Addiction and the Department of Psychiatry. First given in 2000, the award honors Dr. Scott Mackler who is known for his excellence in teaching medical students, residents, post- Zoe Wilson, MD received the 2011 Graduate Education doctoral fellows, nurses, and other Penn faculty in the area Committee Award for Excellence in Child and Adolescent Psy- of substance abuse. chiatry.

Continued on page 8

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 8 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 7 Penn/Perelman School of Medicine Honors Janet E. Audrain-McGovern, PhD was selected to serve ~~RECENT LEADERSHIP APPOINTMENTS~~ as a Hearing Panel Member for the University-wide Stu- dent Disciplinary System. She also became a Senior Fel- Thomas N. Ferraro, PhD is serving as Assistant low at three centers at Penn – the Leonard Davis Institute Dean for Animal Research in the Perelman School of Health Economics, Center for Health Incentives and Behavioral Economics, and Center for Health Behavior of Medicine. In this role, he oversees all aspects of Research. animal research in the medical school, including strategic planning for programs and facilities, Michael B. Blank, PhD was named Distinguished point person and liaison activities with University and external Research Fellow of the Annenberg Public Policy Center at entities concerning regulatory compliance and programmatic Penn. development, and medical school policies and procedures for E. Cabrina Campbell, MD was a Faculty Inductee into animal research and care issues. He also is Chair of the Perel- the Perelman School of Medicine Minority Hall of Fame man School of Medicine’s Animal Research Committee. for her leadership in mentoring and teaching underrepresented minorities in medicine. Mahendra T. Bhati, MD was appointed Director C. Neill Epperson, MD was elected to the Penn Women’s of the Neuromodulation Program, which Health Leadership Council. includes electroconvulsive therapy (ECT), tran- Michael Gandal, PhD, a student in the laboratory of scranial magnetic stimulation (TMS), vagal nerve Steven J. Siegel, MD, PhD, received the 2011 Flexner stimulation (VNS), and deep brain stimulation Award for Outstanding Thesis Work in the Neuro- (DBS), effective September 1, 2011. sciences. Students in any graduate group who did their PhD on a neuroscience-related topic in any lab across the University are eligible for the Flexner Award. Recipients Henry R. Kranzler, MD was appointed Co-Direc- are selected by the Neuroscience Graduate Group tor of the Center for Studies of Addiction. Dr. Awards Committee. Kranzler came to Penn in December 2010 from the Caryn Lerman, PhD received the 2011 William Osler University of Connecticut School of Medicine. Patient Oriented Research Award. This award “recognizes outstanding achievement for research in which the investigator directly interacts with human subjects.” Caryn Lerman, PhD served as Interim Director of Helen M. Pettinati, PhD was elected President of the the Abramson Cancer Center (ACC) from October John Morgan Society at the Perelman School of Medicine 15, 2010 until the appointment of the new Director, for the 2011-2012 term. Prior to her presidency, she Chi Van Dang, MD, PhD, on September 1, 2011. She served as the Society’s Secretary-Treasurer from 2010 to has served as the ACC’s Deputy Director since 2006. 2011. Also, E. Cabrina Campbell, MD, David F. Dinges, Further, she led the ACC’s Strategic Planning Committee and PhD, C. Neill Epperson, MD, Kyle M. Kampman, MD, played a major role in the recent highly successful competitive Henry R. Kranzler, MD, David W. Oslin, MD, and renewal of the National Cancer Institute (NCI) Cancer Center Daniel H. Wolf, MD, PhD were recently elected into the Support Grant. Society, which honors outstanding faculty from the Schools of Medicine, Dental Medicine, Veterinary Medi- cine, and Nursing. David S. Mandell, ScD was appointed Associate Director of the Center for Mental Health Policy Andrew A. Strasser, PhD was appointed Research Fellow and Services Research. of the Annenberg Public Policy Center for the period 2010 to 2013.

REGIONAL, NATIONAL AND Dwight L. Evans, MD was appointed Co-Director of the Penn INTERNATIONAL HONORS Comprehensive Neuroscience Center (CNC), joining Amita Sehgal, PhD of the Department of Neuroscience as CNC Co- Steven E. Arnold, MD was appointed to the Editorial Director. The CNC was created in 2006 to emphasize the Neu- Boards of Neuropsychiatry and Translational Neuroscience. rosciences as an area for development. As its highest priorities, He also served as Chair of the Working Group for the CNC has taken major strides in its brief existence to fully Research at the Interface between Neurodegenerative Dis- integrate Neuroscience-related clinical care, research, and edu- eases and Late-Life Psychiatric Disorders at the National Institute of Mental Health (NIMH). In addition, Dr. cation programs to enhance Penn’s position at the forefront of the Neurosciences nationwide. Continued on page 9

www.med.upenn.edu/psych PAGE 9 www.med.upenn.edu/psych

Continued from page 8 Arnold was appointed to the Alzheimer's Disease Centers ~~ PENN TEACHING AWARDS ~~ Clinical Core Steering Committee and to the Scientific Review Committee of the National Alzheimer's Coordinating Center, both supported by the National Institute on Aging (NIA). Stanley N. Caroff, MD received the 2011 I.S. Ravdin Master Clinician Award. This honor “recognizes an Janet E. Audrain-McGovern, PhD was invited to serve a active master clinician who is a skillful, compassion- three-year term as Associate Editor of the journal Nicotine & ate practitioner with a long and consistent record of Tobacco Research. contributions to the Penn School of Medicine and Health System.” Tracy L. Bale, PhD received the 2011 Richard E. Weitzman Memorial Award from the Endocrine Benoit Dubé, MD received the 2011 Provost’s Society in July 2011. The award is presented Award for Distinguished Teaching Excellence. This annually to a young investigator “in recognition prestigious honor recognizes educators whose teach- of meritorious accomplishments in the field of ing is intellectually demanding, unusually coherent, endocrinology” and is one of 11 laureate awards and permanent in its effect. In December 2011, Dr. given annually by the Endocrine Society. Dubé received the Module 2 Teaching Award from Mathias Basner, MD, PhD, MSc received the Science Award the medical student Entering Class of 2010 for his contributions to of the German Academy for Aviation and Travel Medicine – the Brain and Behavior course in the Spring of 2011. The award the Albrecht-Ludwig-Berblinger-Award – for his seminal represents the Class’ expression of “gratitude to the professors research on the effects of commercial aircraft noise on sleep who enthusiastically instructed and mentored (them) since their and health in populations living near urban airports (Basner arrival at Penn Med." M, Siebert U. Markov Processes for the Prediction of Aircraft- Noise Effects on Sleep. Medical Decision Making 30[2]: 275-289, Anthony L. Rostain, MD, MA will receive the 2012 Mar-Apr 2010). Dr. Basner was presented with the award in Robert Dunning Dripps Memorial Award for Excel- August 2010, when he delivered a major lecture at the 48th lence in Graduate Medical Education. This award rec- Annual Congress of the German Society of Aerospace Medi- ognizes excellence as an educator of residents and cine in Wiesbaden, Germany. The award was accompanied by fellows in clinical care, research, teaching, or adminis- 10,000 Euros. Dr. Basner was also re-elected Secretary of the tration. International Commission of Biological Effects of Noise (ICBEN) in July 2011 at the ICBEN meeting in London. The Steven J. Siegel, MD, PhD received the 2011 main goal of ICBEN is to promote a high level of scientific Leonard Berwick Memorial Teaching Award. This research concerning all the aspects of noise-induced effects on award recognizes "a member of the medical faculty human beings and on animals, including preventive regulato- who in his or her teaching effectively fuses basic sci- ry measures, and to keep alive a vivid communication among ence and clinical medicine." It particularly honors the scientists working in that field. He was also re-elected Co- outstanding teachers among the younger faculty. Chair of ICBEN Team 5: “The Effects of Noise on Sleep.”

Alissa E. Silverman, PsyD received the 2011 Dean’s Aaron T. Beck, MD received the 11th Annual Bell of Hope Award for Excellence in Medical Student Teaching by Award in May 2010 from the Mental Health Association of an Allied Health Professional. This award recognizes Southeastern Pennsylvania. This lifetime achievement award outstanding teaching by allied health professionals was given to Dr. Beck for significant and far-reaching contri- (e.g., nurses, physicians assistants, emergency medical butions benefiting individuals facing the challenges of mental technicians). The recipient is selected on the advice of illness. In November 2010, he received the 2010 Sigmund a committee composed of faculty and students. Freud Award from the New York Chapter of the American Society of Psychoanalytic Physicians. His lecture titled "My Anthony Carlino, MD and Matthew Early Introduction to Psychoanalytic Therapy," which dis- Kayser, MD, PhD, both Psychiatry resi- cussed the history of how he discovered automatic thoughts, dents in the Class of 2013, received 2011 was delivered at the awards ceremony. He also received the Penn Pearls Award for Excellence in Clini- Edward J. Sachar Award from the Department of Psychiatry at cal Teaching from the Medical Student Columbia University in December 2011. Dr. Beck was also Government. This award is given in honor honored with the 2010 Scholarship and Research Award from of outstanding contributions to medical student education at the the National Alliance on Mental Illness of Pennsylvania for his Perelman School of Medicine and is managed by AOA students. current research on cognitive behavior therapy for schizophre- Alysia Cirona, MD received the 2011 Medical Stu- nia. Dr. Beck and Dr. David Clark received the 2010 Book of dent Teaching Award. This award is given to a resi- the Year Award from the American Journal of Nursing for their dent who has been a consistently outstanding publication, Cognitive Therapy of Anxiety Disorders: Science and teacher of medical students. Practice. AJN's panel of judges recognized the book as the "most valuable psychiatric-mental health nursing text of 2010." In January 2012, Dr. Beck was recognized as a co-recipient of the Prince Mahidol Award in Medicine for his outstanding contribution in the development of cognitive behavioral therapy.

Continued on page 10

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 10 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 9

Judith S. Beck, PhD received the Award for Outstanding Con- David F. Dinges, PhD was elected a member of the Internation- tribution by an Individual for Clinical Activities from the Asso- al Academy of Astronautics. Founded in 1960, the Academy ciation for Behavioral and Cognitive Therapies (ABCT) in includes the world's foremost experts in astronautics to foster November 2011. the development of astronautics for peaceful purposes, to recog- nize individuals who have distinguished themselves in a branch Tami D. Benton, MD became a Section Editor for the Child and of science or technology related to astronautics, and to provide a Adolescent Psychiatry Current Psychiatry Reports publication. program through which the membership can contribute to international endeavors and cooperation in the advancement of aero- Robert I. Berkowitz, MD serves on the editorial board of the space science, in cooperation with national science or International Journal of Obesity. engineering academies. In addition, for the eleventh consecutive year, Dr. Dinges was selected to continue as Team Leader for Henry R. Bleier, MD, MBA received the 2010 Psy- the National Space Biomedical Research Institute’s Neurobehav- chiatric Educator of Physicians Award from the ioral and Psychosocial Factors Team for human space flight. He Philadelphia Psychiatric Society in November 2010. was also asked by the Boards of the American Academy of Sleep This award is given in recognition of the recipient’s Medicine and the Sleep Research Society to serve a second five- outstanding teaching or research abilities. year term (2012-2017) as Editor-in-Chief of SLEEP, the leading Rhonda C. Boyd, PhD serves as co-chair of the Child Depres- biomedical publication in the world dedicated to sleep medicine sion Workgroup in the Emerging Scholars Interdisciplinary Net- and sleep research. work. She also became a member of the Diversity Network C. Neill Epperson, MD was elected a Committee of the Society for Prevention member of the College on the Problems of Research. Drug Dependence and was elected to the Stanley N. Caroff, MD is Director of the Lerman Elected to IOM Philadelphia Forum for Executive Women. Neuroleptic Malignant Syndrome Infor- She was also invited to be Co-Chair of the mation Service, a division of the Malig- Committee on Women of the Philadelphia Caryn Lerman, PhD was elect- nant Hyperthermia Association of the Psychiatric Society. Dr. Epperson served United States (MHAUS), a non-profit ed in 2010 to membership in the as the opponent for the doctoral defense of advocacy group headquartered in Sher- Institute of Medicine (IOM) of the Erika Temby, MD at Umea University in burne, New York. National Academies, one of the Umea, Sweden – contributing in this role nation's highest honors in bio- is considered an honor in Europe. In addi- Kenneth D. Cohen, MD was honored by medicine. She joins four other tion, she co-Chaired with Ellen Freeman, PhD (Obstetrics and Gynecology) a panel the Belmont Behavioral Treatment Center Department of Psychiatry faculty in Philadelphia in June 2010 at the annual at the Annual Meeting of the American who are members – Aaron T. dinner for the graduation of the Albert Psychiatric Society titled “Mood, Memory Einstein Medical Center psychiatry resi- Beck, MD (1997); Raquel E. Gur, and Myths: What Really Happens at dents with the establishment of the MD, PhD (2001); Charles P. Menopause” in Honolulu, Hawaii in May Annual Kenneth D. Cohen Academic O’Brien, MD, PhD (1991); and 2011. Excellence Award. Dr. Cohen has a long Albert J. Stunkard, MD (1988). history with Albert Einstein and with Bel- Newell Fischer, MD was elected to the mont. Among other connections, Dr. Executive Committee of the International Cohen was formerly Belmont’s Clinical Psychoanalytic Association to represent Director and Director of Professional Education from 1973 to the United States, Canada, and Japan. He was also elected Chair 1980. Dr. Cohen is Clinical Professor of Psychiatry at Penn, and of the Education Committee of the Psychoanalytic Center of has been teaching and supervising in Penn’s Department of Psy- Philadelphia. chiatry for over 50 years. Currently, he is responsible for organ- Edna B. Foa, PhD received the 2010 Award for Lifetime izing a dynamic psychotherapy conference at Penn for the Achievement in the Field of Trauma Psychology from the Amer- PGY-4 residents that runs through July, August, and September. ican Psychological Association (APA) at its Convention in San Guy S. Diamond, PhD received the 2010 Marilyn Mennis Diego in August 2010. The Lifetime Achievement Award “rec- Memorial Award from the Pennsylvania Community Providers ognizes a senior distinguished psychologist who has made out- Association (PCPA) Board of Directors in October 2010. This standing contributions to science, practice, advocacy, and/or award, established in 1995, is presented to an individual or pro- education/training over the course of his/her career … at such gram that reflects Ms. Mennis’ qualities of dedication, caring, a level that they have advanced the field of trauma psychology.” leadership, and advocacy on behalf of Pennsylvania’s children At the convention, Dr. Foa delivered the Harry Kirke Wolfe Lec- with special needs and their families. ture on “PTSD: Diagnosis, Theory, and Evidence-based Treat- ment.” Also, Dr. Foa was the first recipient of the Outstanding Joseph DiGiacomo, MD received the Nancy C. A. Roeske MD Career Achievement Award from the International Obsessive Certificate of Recognition for Excellence in Medical Student Compulsive Disorder Foundation in July 2011. She was honored Education at the Annual Meeting of the American Psychiatric “for her pioneering work on the treatment and understanding of Association (APA) in New Orleans in May 2010. This award OCD.” honors APA members who have made “significant and sustained contributions…to the advancement of medical student Rollin M. Gallagher, MD received the John B. Murtha Award education.” in September 2011 for service to military pain medicine from the Continued on page 11

www.med.upenn.edu/psych PAGE 11 www.med.upenn.edu/psych

Continued from page 10

the Educational Programs Committee of Craig Lichtman, MD, MBA Raquel Gur receives ACP the Sleep Research Society in June 2011. co-founded and co-chaired Menninger Award the new “Psychotherapeu- Trevor R. Hadley, PhD received the tic Approaches to the Med- 2011 Benjamin Rush Award from the ically Ill” Special Interest Philadelphia Psychiatric Society. The Raquel E. Gur, Group at the Annual Meet- Rush Award is given to “a non-psychia- ing of the Academy of Psychosomatic MD, PhD received trist who has brought recognition to Medicine in November 2011 in Phoenix. the 2011 William mental illness/health over the past In May 2011, he became a member of C. Menninger Memorial Award year.” Dr. Hadley received the honor at the Board of Directors of PLAN of for Distinguished Contributions the Society’s Benjamin Rush Event in Pennsylvania, a non-profit agency, to the Science of Mental Health November 2011. which provides planning, special needs from the American College of trust, representative payee, and care Steven F. Huege, MD management services to families of Physicians (ACP) at the ACP’s received a Geriatric Aca- Annual Meeting in April 2011 in adults with mental illness, intellectual demic Career Award disabilities, autism, and brain injury, as San Diego. The award was (GACA) from the Health well as other lifelong disabilities. established in 1967 and was Resources and Services named for Dr. Menninger who Administration (HRSA). Deborah Anna Luepnitz, PhD received was a Governor, Regent, and The purpose of the award is to increase the 2011 Award for Achievement in the first President of the Col- the number of junior faculty at accredit- Psychoanalytic Education from the lege. Albert J. Stunkard, MD ed schools of allopathic and osteopathic Philadelphia Society for Psychoanalytic medicine and to promote the develop- (1980), Aaron T. Beck, MD Psychology in November 2011. ment of their careers as academic geria- (2007), and Dwight L. Evans, tricians who emphasize training in Scott Mackler, MD, PhD, a Newark, MD (2009) from the Depart- clinical geriatrics, including the training Delaware resident, was awarded the ment of Psychiatry are past of interdisciplinary teams of health pro- Order of the First State from Delaware recipients of this prestigious fessionals. Dr. Huege was Co-Chair of Governor Jack Markell in 2010. Dr. award. the Geriatric Mental Health Founda- Mackler continues to teach and conduct tion’s Scholars Program for Medical Stu- research a decade after being diagnosed dents at the 2011 and 2012 Annual with Amyotrophic Lateral Sclerosis Defense and Veterans Center for Inte- Meetings of the American Association (ALS) and is working with students to grated Pain Management, a component for Geriatric Psychiatry. investigate the molecular mechanisms of the Department of Defense. In underlying cocaine addiction. November 2011, he was honored with Chanita Hughes-Halbert, PhD was the Josefina Magno Award for Leader- elected to the Minorities in Cancer David S. Mandell, ScD accepted an ship in Program Excellence Dedicated to Research Council at the American Asso- invitation from the Center for Scientific Military Service Personnel from Capital ciation for Cancer Research. Review of the NIH to serve as a mem- Caring in Falls Church, Virginia. Capital ber of the Dissemination and Implemen- Caring provides palliative and hospice Matthew Hurford, MD was elected tation Research in Health Study Section. care in Virginia, Washington, DC, and Early Career Psychiatrist representative The term runs until June 30, 2014. Mem- Maryland. In addition, Dr. Gallagher to the Pennsylvania Psychiatric Society bers are selected based on “their was selected in 2011 as Co-Chair of the and was named Chair of the Communi- demonstrated competence and achieve- Department of Defense-VA Health ty Psychiatric Committee for the ment in their scientific discipline.” He Executive Committee's Pain Manage- Philadelphia Psychiatric Society. also received the American Public ment Work Group. Health Association (APHA) Mental Kyle M. Kampman, MD served as a Health Section Award, was named the Namni Goel, PhD completed her term member of an NIH grant study section Scientific Program Chair for the 2010 as President of the Society for Light within the Center for Scientific Review’s International Meeting for Autism Treatment and Biological Rhythms in Risk, Prevention and Health Behavior Research, and was selected as Co-Editor July 2010. Her term as Immediate Past Integrated Review Group in June 2010. of Autism: The International Journal of President runs through July 2012. She Also in 2010, he was selected as a Mem- Research and Practice. He also received served as a member of the Organizing ber of the American College of Neu- the Variety Club Autism Award. Committee for the July 2010 Annual ropsychopharmacology and appointed Meeting of the Society for Light Treat- Associate Editor of the journal Drug and David S. Metzger, PhD received the ment and Biological Rhythms in Vienna, Alcohol Dependence. Penn Center for AIDS Research (CFAR) Austria. Dr. Goel was named Academic Community Advisory Board’s Red Rib- Editor of PLoS ONE in July 2010, a Caryn Lerman, PhD is leading a bon Award for Excellence in Interna- member of the Editorial Board of the National Institute on Drug Abuse tional Research. He is a member of the Journal of Neurology Research in February (NIDA) Council Workgroup on the Executive Committee of the national 2011, and Review Editor of Frontiers in “Translation of Evidence-Based Inter- CFAR Social and Behavioral Sciences Behavioral and Psychiatric Genetics in July ventions for Substance Abuse to Prac- Research Network. Dr. Metzger also 2011. She was appointed a member of tice.” serves on the Advisory Board of Project Continued on page 13

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 12 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Clinical Recognitions

The Department ranked 12th nationally in the 2011-12 US News & World Report’s Annual Rank- ing of Best Hospitals for the quality of its psychiatry clinical services. The psychiatric service improved from rank 14 in 2010-11. Overall, the Hospital of the University of Pennsylvania (HUP) ranked 10th nationally, continuing its presence in the survey’s “Honor Roll,” and marking the fourth consecutive year that the hospital ranked in the top ten nationwide. HUP remains the top ranked hospital for psychiatric care in the region.

The Department’s Drug and Alcohol Abuse program ranked #5 in the 2012-13 U.S. News & World Report annual survey of medical schools and their specialty programs. The Perelman School of Medicine achieved a #2 ranking, retaining its position from the previous survey.

A number of Department of Psychiatry physicians were recognized by Philadelphia Magazine as “Top Doctors” in the region, as reported in the April 2011 issue – Kyle M. Kampman, MD (Addiction Psychiatry); Anthony L. Rostain, MD, MA (Child and Adolescent Psychiatry); Joel E. Streim, MD (Geriatric Psychiatry); Steven E. Arnold, MD (Psychiatry; Alzheimer’s Disease); Edward S. Brodkin, MD (Psychiatry); and Michael E. Thase, MD (Psychiatry).

Six Department of Psychiatry physicians were recognized in Castle Connolly's 2011 edition of America's Top Doctors. Physicians are selected on the basis of "peer nomination, extensive research and careful review and screening by [a] doctor-directed research team." The Depart- ment faculty recognized in 2011 include: Steven E. Arnold, MD, Edward S. Brodkin, MD, Kyle M. Kampman, MD, Anthony L. Rostain, MD, MA, Joel E. Streim, MD, and Michael E. Thase, MD.

Thirty Department of Psychiatry physicians were recognized as "2011-2012 Best Doctors in America." The list, compiled by Best Doctors, Inc., is composed of physicians who have been selected by the consensus of their peers. The Department faculty recognized in the survey are: Jay D. Amsterdam, MD, Steven E. Arnold, MD, Christos Ballas, MD, Wade H. Berrettini, MD, PhD, Henry R. Bleier, MD, MBA, Lawrence D. Blum, MD, James W. Cornish, MD, Charles Dackis, MD, Sarah C. DeMichele, MD, C. Neill Epperson, MD, Dwight L. Evans, MD, David L. Fink, MD, Newell Fischer, MD, Ruth S. Fischer, MD, Rollin M. Gal- lagher, MD, Laszlo Gyulai, MD, Kyle M. Kampman, MD, Marc Lipschutz, MD, Michael McCarthy, MD, Charles P. O'Brien, MD, PhD, David W. Oslin, MD, Anthony L. Rostain, MD, MA, Robert L. Sadoff, MD, James L. Stinnett, MD, Andrew M. Stone, MD, Joel E. Streim, MD, Michael E. Thase, MD, Robert M. Toborowsky, MD, Robert M. Weinrieb, MD, and Daniel Weintraub, MD.

Matthew Hurford, MD and the clinical team at the Hall Mercer Community Behavioral Health Center at Penn- sylvania Hospital received a University of Pennsylvania Health System (UPHS) Quality and Patient Safety Award for the project titled “Access and Service Continuity Improvement Project at Hall Mercer Community Behavioral Health Center.” This project is aimed at reducing wait times for initial appointments, increasing patient show-rates, and improving continuity of patient care. Dr. Hurford and the team received the award at a UPHS awards ceremony in October 2010.

Cathy A. Mercaldi, MD was listed in America’s Top Psychiatrists 2010 and 2011 by the Consumer’s Research Council of America.

The Behavioral Health Laboratory (BHL) at the Philadelphia VA Medical Center, led by David W. Oslin, MD, was awarded the American Psychiatric Association Bronze Award for clinical innovations. The BHL was developed to support the delivery and improve the outcomes for primary care patients with behavioral health problems. It has become a national model within the VA system and recognized as a Best Practice Model.

www.med.upenn.edu/psych PAGE 13 www.med.upenn.edu/psych

Continued from page 11 Legacy, a National Institute of Allergy and psychiatric disorders and Infectious Diseases (NIAID) support- in the American armed O’Brien receives IOM ed initiative to increase the number of forces. In October 2011, he Sarnat International Prize investigators and participants from served as President of the underrepresented minorities in AIDS- European and Interna- related biomedical research. tional Congress on Charles P. O’Brien, MD, PhD and Addiction, Hepatitis, and Eric J. Nestler, MD, PhD of the Stephen J. Morse, JD, PhD is a member AIDS in Biarritz, France. of the newly-funded MacArthur Research Mount Sinai School of Medicine Network on Law and Neuroscience. The Helen M. Pettinati, PhD were co-recipients of the 2010 project is funded through 2014 and Dr. received the Dan Ander- Rhoda and Bernard Sarnat International Prize in Men- Morse is only one of thirteen participat- son Research Award tal Health from the Institute of Medicine (IOM). Rhoda ing researchers nationwide. Supported by from the Hazelden Foun- and Bernard Sarnat established the award in 1992 out the John D. and Catherine T. MacArthur dation. This award rec- of a commitment to improving the science base and Foundation, the Research Network funds ognizes a single delivery of mental health services. This international research at the intersection of neuro- published article of an award recognizes individuals, groups, or organizations for outstanding achievement in improving mental science and criminal justice, including original, innovative, and health and is accompanied by a medal and $20,000. In issues related to the mental states of creative work by a the words of the selection committee, Dr. O’Brien was defendants and witnesses, a defendant’s researcher who has honored “for making discoveries that have become the capacity for self-regulating his behavior, advanced the scientific standard of care in alcohol and drug addiction treat- and the introduction of neuroscientific knowledge of addiction ment and for demonstrating the neurobiological foun- evidence in court. Dr. Morse will focus recovery. Dr. Pettinati’s dations for symptoms of addiction.” Dr. O’Brien now his research on the neuroscience of legal- award-winning paper joins Department of Psychiatry colleagues Aaron T. ly relevant self-control capacity and on reported the first con- Beck, MD (2003) and Albert J. Stunkard, MD (2004) as the neuroscientific correlates of different trolled trial demonstrat- winners of this distinguished accolade. Dr. O’Brien mental states, such as recklessness and ing that a combination of received the award at the IOM’s Annual Meeting in negligence, that are crucial to criminal an antidepressant and an October 2010 in Washington, DC. law. In addition, Dr. Morse is a Member anti-craving medication of the Board of the Bazelon Center for was significantly better Mental Health and Law in Washington, than either treatment President of the Academy of Experimen- DC and serves on the Nominations and alone or placebo for treating patients with tal Criminology (AEC). The AEC, a divi- Finance Committees. The Bazelon Center both depression and excessive drinking - sion of the American Society of is a nonprofit organization devoted to a very commonly seen comorbidity (Petti- Criminology, was founded in 1999 to rec- improving the lives of people with men- nati HM, Oslin DW, Kampman KM, Dun- ognize criminologists who have success- tal illnesses through changes in policy don WD, Xie H, Gallis TL, Dackis CA, fully led randomized, controlled, field and law. and O'Brien CP. A double-blind, placebo- experiments in criminology. controlled trial combining sertraline and Cory F. Newman, PhD was promoted to naltrexone for treating co-occurring J. Russell Ramsay, PhD is an invited the rank of Professor of Psychology in depression and alcohol dependence. Am J member of the Society for Adolescent Psychiatry in the Standing Faculty of the Psychiatry 167: 688-675, 2010). Dr. Petti- Health and Medicine’s (SAHM) initiative, Perelman School of Medicine. Dr. New- nati received the award in May 2011 at “Navigating Change Points: Improving man also served as Visiting Professor in the Annual Meeting of the National Asso- ADHD Care in Our Nation’s Adoles- the Department of Psychology and Neu- ciation of Addiction Treatment Providers cents.” He is representing the Attention rosciences at the University of Colorado (NAATP) in Chandler, Arizona, where Deficit Disorder Association (ADDA) in at Boulder from July 1, 2011 until Decem- she summarized her paper in the Plenary this effort. ber 31, 2011. There he taught an upper- Session. level graduate course titled “Introduction Paul M. Robins, PhD serves on the Edi- to Becoming a Clinical Supervisor,” the Jennifer G. Plebani, PhD became a mem- torial Board of the Journal of Pediatric Psy- first course of its type in the department’s ber of the Association for Psychological chology and on the Executive Board of the history. The course was videotaped so Science (APS) in 2010. Society of Pediatric Psychology. He also that other faculty at CU-Boulder may serves as an Internship Site Visit Chair in continue to teach it from 2012 forward. In R. Arlen Price, PhD was appointed to the the Office of Accreditation of the Ameri- November 2011, Dr. Newman's book (co- editorial board of a new journal, Frontiers can Psychological Association (APA) and authored with Dr. Thomas Ellis of the in Behavioral and Psychiatric Genetics. as a Regional Federal Action Coordinator Menninger Clinic) titled Choosing to Live: in the APA’s Education Directorate. How to Defeat Suicide Through Cognitive Sydney Pulver, MD served Therapy was chosen as a Self-Help Book as Chair of a panel titled Anthony L. Rostain, MD, MA is the Seal of Merit Winner by the Association "How and When Does President of the American Professional for Behavioral and Cognitive Therapy. Treatment End?" at the Society of ADHD and Related Disorders Winter Meeting of the (APSARD). Charles P. O’Brien, MD, PhD has been American Psychoanalytic asked to chair a committee of the Institute Association held in New York City in Jan- Robert L. Sadoff, MD received two pres- of Medicine requested by Congress to uary 2012. tigious awards. In November 2010, he examine the problems of substance abuse received the Presidential Award from the Adrian Raine, PhD was elected Vice Pennsylvania Psychiatric Society, its high- Continued on page 14

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 14 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 13 est honor. In October 2010, he was presented with the Distinguished Alumni Award from the University of Peter C. Whybrow, MD Minnesota Medical Alumni Society, which recognizes University of Min- Portrait Unveiling nesota medical school alumni “who have made outstanding contributions On February 9, 2012, the Perel- to their communities – at the local, man School of Medicine and the regional or national level – through medical practice, teaching, research or Department of Psychiatry honored other humanitarian activities.” Dr. former Chairman Peter C. Why- Sadoff was also honored with the brow, MD with a ceremony and establishment of the Robert L. Sadoff reception to accompany the Lecture in Forensic Psychiatry at the unveiling of his portrait. Dr. Why- College of Physicians of Philadelphia brow served as Department Chair in perpetuity. He also initiated and from 1984 to 1996, and is now the developed the Section on Medicine, Judson Braun Distinguished Pro- Ethics and Law at the College. fessor and Executive Chair of the Robert A. Schnoll, PhD was named Department of Psychiatry and Chairperson of the Risk, Prevention, Biobehavioral Sciences at the and Intervention for Addictions NIH David Geffen School of Medicine Study Section in September 2011. He at UCLA. As part of the celebra- was also nominated to membership tion, Dr. Whybrow delivered a lec- on the Strategic Planning Committee ture titled “Reflections on the for the Society for Research on Nico- Philadelphia Story.” tine and Tobacco. From left: Dwight L. Evans, MD; Peter C. Why- brow, MD, Arthur H. Rubenstein, MBBCh Steven J. Siegel, MD, PhD advanced to Fellow in the American College of Neuropsychopharmacology. of Graduate Medical Education. can Psychology-Law Society on “Ani- Joel E. Streim, MD was mal Hoarding” in Boston in July. appointed to the Centers Michael E. Thase, MD received the for Medicare & Medicaid 2012 Award for Research in Mood Dis- Daniel H. Wolf, MD, PhD received, in Services (CMS) Technical orders from the American College of 2009, the Young Investigator Memorial Expert Panel for Inpatient Psychiatrists in February 2012. This Fellowship Travel Award from the Psychiatric Quality Meas- award is given to an “individual who American College of Neuropsychophar- ure Development. This technical expert has advanced the understanding and macology (ACNP) and the NARSAD panel (TEP) is a group of stakeholders treatment of mood disorders.” Sidney R. Baer, Jr. Prize for Schizophre- and experts who will provide input on nia Research. Daniel Weintraub, MD was appointed the development, selection, and mainte- to the Editorial Advisory Board of CNS George E. Woody, MD served as a nance of measures for which CMS con- Spectrums. He was also appointed to the member of several important entities – tractors are responsible. Dr. Streim will Executive Committee of the Parkinson the FDA External Advisory Group on contribute his expertise related to meas- Study Group and to the Diagnostic and the question of scheduling dextromor- ures of quality of care for older adults Statistical Manual (DSM)-V Task Force phan; the Executive Committee and with medical-psychiatric comorbidity as advisor to the Sleep-Wake Disorders Publications Committee of the National and associated disability. Work Group and the Cognitive Work Institute on Drug Addiction (NIDA) Richard F. Summers, MD is serving a Group. In addition, Dr. Weintraub was Clinical Trials Network; the External one-year term as President of the Amer- appointed to the Movement Disorder Scientific Advisory Board of the Texas ican Association of Directors of Psychi- Society’s Committee on Rating Scales in Node of the NIDA Clinical Trials Net- atry Residency Training until March Movement Disorders. work; and the Program Development 2012. In 2010, he was selected as a Dis- Committee of the College on Problems Kenneth J. Weiss, MD was selected tinguished Fellow of the American Psy- of Drug Dependence. He also served as Outstanding Teacher in a Forensic Fel- chiatric Association and was appointed an external reviewer for the Behavioral lowship by the American Academy of Chair of the American Psychoanalytic and Social Consequences of HIV/AIDS Psychiatry and the Law in October Association’s Psychodynamic and Psy- (BSCH) Study Section at the NIH. 2011. He was elected Secretary of the choanalytic Teachers’ Academy. In the Philadelphia Psychiatric Society in June fall of 2011, he was appointed to the 2011. Dr. Weiss co-led (with Gary Advisory Group of the Psychiatry Mile- Patronek, DVM, PhD) an interdiscipli- stones Project of the American Council nary conference funded by the Ameri-

www.med.upenn.edu/psych PAGE 15 www.med.upenn.edu/psych

NEWS & GOINGS ON

Kelly C. Allison, PhD was an invited Judith S. Beck, PhD spoke to multiple South Korea. In August 2011, she gave a speaker on “Behavioral Issues in Weight regional, national, and international audi- Plenary Session on “Up Close and Person- Management,” given in October 2011 at St. ences in 2010 and 2011. Among them, she al with Judith S. Beck, PhD” and also pre- Luke’s Hospital Bariatric Services’ First gave a Keynote Address on “Cognitive sented on “CBT for Personality Disorders” Annual Bariatric Symposium on “Update Behavior Therapy (CBT) for Personality at the Annual Convention of the American on Obesity: A Multidisciplinary Disorders” and also spoke on the “Cogni- Psychological Association in Washington, Approach” in Allentown, Pennsylvania. tive Behavioral Approach to Weight Loss” DC. She was also an invited speaker on at a meeting of the European Association “Women and Weight: Why Is It So Com- for Behavioural and Cognitive Therapies Steven J. Berkowitz, MD presented on the plicated?” at Community Rounds spon- in October 2010 in Milan, Italy. In May “Child and Family Traumatic Stress Inter- sored by the Penn Center for Women’s 2011, she presented on “CBT for Personali- vention” in June 2011 in Rome, Italy for a Behavioral Wellness in October. World Health Organization (WHO) conference on disaster response. In October, he Janet E. Audrain-McGovern, PhD gave a led a Learning Collaborative Training for talk on “Adolescent Smoking Preven- The Department's Psychopathology six agencies from six states on “Child tion” at an October 2011 CANPrevent Research Unit has a new name – The Aaron and Family Traumatic Stress Interven- Lung Cancer Conference sponsored by T. Beck Psychopathology Research tion.”He served as faculty for a seminar the Abramson Cancer Center. Center. Named after its founder and current on recognizing and intervening with Director, Aaron T. Beck, MD, the Center will traumatized children as a pediatrician at Mathias Basner, MD, PhD, MSc gave an continue and extend both research and clini- the American Academy of Pediatrics invited talk at the Medical Device Alarms cal training in severe psychopathology, work National Conference in October in Summit in Herndon, Virginia in October that has been ongoing for over five decades. Boston. In November, Dr. Berkowitz pre- 2011, hosted by the Association for the Center faculty and staff evaluate the effective- sented to the Pennsylvania Bar Institute Advancement of Medical Instrumenta- ness of evidence-based treatments, such as on “The Relationship Between Early Life tion. The talk was titled "Noise - The cognitive behavioral therapy, in applied com- Trauma and Criminality.” Other Negative Effect of False Alarms.” munity settings and investigate ways to (For more details, please visit improve the dissemination of these treatments Peter B. Bloom, MD conducted a 14- http://www.aami.org/alarms/index.html.) to the public. Center personnel also conduct hour advanced workshop for about 45 clinical training for medical professionals, with established clinicians from all specialties Aaron T. Beck, MD and his team at the special training programs for clinicians on “Effective Treatment Techniques for Aaron T. Beck Psychopathology Research employed at Philadelphia-area community Contemporary Practice" at the New Eng- Center (ATB-PRC), in partnership with mental health centers and at VA medical cen- land Society of Clinical Hypnosis in May the City of Philadelphia’s Department of ters across the country. Dr. Beck is known 2010. Dr. Bloom, who retired from clini- Behavioral Health and Intellectual dis- world-wide as the inventor of cognitive thera- cal practice in July 2010, used the work- Ability Service’s Community Behavioral py, the most empirically supported of any shop to share with his colleagues what Health Division, are actively implement- form of psychotherapy. He has been richly he had learned throughout his distin- ing The Beck Initiative, a large-scale honored nationally and internationally for his guished career. (For more about Dr. effort to disseminate cognitive therapy life-long contributions to improving the mental Bloom, please see the “Voluntary Faculty principles and applications to therapists health of the world's people, most notably with Profile” about him in the Winter 2009 in community mental health agencies in the 2006 Albert Lasker Clinical Medical issue of Penn Psychiatry Perspective – Philadelphia, as well as therapists in the Research Award, the most prestigious honor http://www.med.upenn. Veterans Health Care System. Special bestowed in American science, and often edu/psych/newsletter.html). Dr. Bloom also efforts are directed at therapists and out- called "America's Nobel." gave a workshop to the New Orleans reach workers in city agencies that work Society of Clinical Hypnosis in Septem- with children and adolescents (“The Beck ber 2011 on "Treating Adolescent Conver- Initiative: Child and Adolescent Expan- sion Disorders: Are Hypnotic Techniques sion”) and case managers who work in ty Disorders” and “High-Yield CBT for Re-useable?" His talk is a published paper, homeless shelters (“The Beck Initiative: Brief Sessions,” and also gave a Master which states that while hypnosis is a valu- Homelessness Expansion”). The ATB-PRC Course on “Practical CBT” at the Annual able adjunct to any therapy, every patient is also redesigning and expanding training Meeting of the American Psychiatric Asso- is different and there are no re-useable in cognitive therapy for nurses, psychiatric ciation in Honolulu. In June, she delivered techniques. techs, occupation therapists, and attend- a Keynote Address on “CBT for Personali- ings working in extended acute inpatient ty Disorders” and spoke on various other Edward S. Brodkin, MD gave an invited units at Temple's Episcopal Hospital in issues concerning the application of cogni- talk in November 2011 in Washington, DC Philadelphia, as well as for Community tive behavior therapy at the 7th Annual on “Deconstructing Sociability in Mouse Treatment Teams. The team has also International Congress of Cognitive Psy- Models” at the 4th Annual Society for trained staff at Horizon House, Inc., a com- chotherapy in Istanbul, Turkey. Dr. Beck Neuroscience Scientific Symposium titled munity behavioral health center in gave a Plenary Lecture on “CBT for Per- “Social Behavior Paradigms in Neuro- Philadelphia, for certification as a Center sonality Disorders” and spoke on “CBT for science.” This satellite symposium of the of Excellence in cognitive therapy. Weight Loss and Maintenance” at the 3rd Annual Meeting of the Society for Neuro- Asian CBT Conference in July in Seoul, science was sponsored by Clever Sys, a bioinformatics company specializing in Continued on page 16

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 16 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 15

automated behavioral testing, including data collection and Behavioral and Cognitive Therapies in San Francisco, she spoke analysis. on “Enhancing Treatment Outcome for Obessive Compulsive Disorder (OCD),” gave a Master Clinician Seminar on “Imple- E. Cabrina Campbell, MD is a Faculty Mentor for the Universi- menting Prolonged Exposure for PTSD: Optimizing Outcomes,” ty of Pennsylvania chapter of the Student National Medical delivered Clinical Ground Rounds on “Prolonged Imaginal Association (SNMA), a national student-run organization focus- Exposure and Cognitive Processing Therapy,” presented an ing on the needs of minority pre-med students, medical stu- Invited Address on “Disseminating Evidence-Based Treatment dents, and health care consumers. She is also a Faculty Mentor Within Systems and Across Countries: Lessons Learned from for the Redfield Group at Penn. The Redfield Group is named Prolonged Exposure Therapy for PTSD,” and gave a workshop for Kay Redfield Jamison, PhD, a psychologist at Johns Hopkins on “Concurrent Treatment for Alcohol Dependence and PTSD.” University who has written extensively, including books about In April 2011, Dr. Foa delivered a Keynote Address on “PTSD: having bipolar disorder herself. At Penn, it is an anonymous Diagnosis, Theory, and Evidence-based Treatment” at the 32nd group of medical students who self-identify as having family or Annual Meeting of the Society of Behavioral Medicine in Wash- personal psychiatric problems. ington DC. In addition, she and other clinicians from the Center Stanley N. Caroff, MD gave a talk on “Movement Disorders for the Treatment and Study of Anxiety (CTSA) trained many Associated with Second Generation Antipsychotics” at the health professionals across the country and world (e.g., Ger- Pennsylvania Psychiatric Society’s Annual Meeting held in King many, Sweden, Norway, and Israel) on the principles and appli- of Prussia in November 2011. cation of Prolonged Exposure (PE) Therapy for PTSD. Judith A. Coché, PhD has returned from colleague training in Teresa R. Franklin, PhD gave an invited lecture in June 2011 in couples group psychotherapy at a conference for systems thera- Belmont, Massachusetts on “Characterizing a Cue-Vulnerable pists in Beilen, Holland, where couples group psychotherapy is Phenotype in Smokers – A Work in Progress” at the Brain Imag- widely used. ing Center at McLean Hospital, a major teaching facility of Har- vard Medical School. In September, she was an invited lecturer David F. Dinges, PhD delivered an invited keynote address on on “Characterizing Pharmaco-responsive Endophenotypes in “The Critical Role Sleep Need Has in Health and Safety” at the Smokers Using Brain, Behavioral and Genetic Markers” at the NIH National Institute of Nursing Research’s 25th Anniversary Program in Neuroscience 2011-2012 Seminar, sponsored by the Symposium in Bethesda, Maryland in September 2010. In University of Massachusetts in Worcester. Also in September, November, he gave the Research in Medical Education (RIME) she gave Department of Psychiatry Grand Rounds at Penn on 28th Invited Address on “Sleep Need and Fatigue Management: “Personalizing Therapies for Smokers Wanting to Quit.” Critical Roles for Professionalism and Medical Education” at the 2010 Annual Meeting of the Association of American Medical Rollin M. Gallagher, MD presented the Annual Sackler Lecture Colleges in Washington, DC. In December, he delivered an at the Tufts New England Medical Center in Boston in April invited keynote address on “Maintaining Human Behavioral 2011 on “The Veterans Administration/Department of Defense Capability: Where Biology Meets Technology” at the 30th Systems Redesign: Pain Management for Wounded Warriors Anniversary Meeting of the Board on Human-Systems Integra- from Injury to Recovery.” Dr. Gallagher also presented the tion of the National Research Council of the National Acade- annual MG Jack Gamble Memorial Research Lecture on mies. In January 2011, Dr. Dinges gave an invited keynote "Stepped Pain Care in the Medical Home: Opportunity and address on “A Brain in Conflict: Sleep and Circadian Impera- Challenge" for the Department of the Army Madigan Health tives in a 24/7 World” at the NIH’s intramural program on System in Tacoma, Washington in August. “Demystifying Medicine 2011” in Bethesda, MD, and in April Seth J. Gillihan, PhD gave a talk on "Prolonged in Houston he delivered the plenary address on “Fridtjof Exposure Therapy for Posttraumatic Stress Disor- Nansen – Lessons for Human Exploration of Space” at the 18th der (PTSD)” in October 2010 in Santiago, Domini- Humans in Space Symposium sponsored by the International can Republic. The talk was part of the ten-day Academy of Astronautics. Dr. Dinges also testified before the “Hispaniola School of Neuroscience: Trauma and U.S. Nuclear Regulatory Commission on proposed new work the Nervous System,” which was supported with schedules for power plants. funds from the NIH and the International Brain Research C. Neill Epperson, MD presented on "Sex, Hormones and the Organization (IBRO). According to the IBRO, this targeted and Brain" and "The Ongoing Saga of Estrogen, Mood and Memory temporary ‘school’ was designed to “enhance the capacity of at Menopause" at the 4th World Congress on Women's Mental Haitian and Dominican participants to understand, teach, and Health in Madrid, Spain in March 2011. She was also a Keynote respond to the mental health consequences of a disaster, such as speaker for the Philadelphia Psychiatric Society's Colloquia of the earthquake that occurred in Port au Prince, Haiti, in early Scholars in March. 2010.” Medical students, psychologists, psychiatrists, neurolo- gists, neurosurgeons, and other physicians, mostly from Haiti, Edna B. Foa, PhD spoke to multiple regional, national, and were among the school’s 20 students. Dr. Gillihan’s role was to international audiences in 2010 and 2011. Among them, she teach about efficacious treatment for PTSD. delivered a Keynote Address in July 2010 on “Psychopathology and Treatment of PTSD: Emotional Processing Theory and Pro- Namni Goel, PhD spoke to multiple regional, national, and longed Exposure (PE) Therapy” at the International Conference international audiences in 2010 and 2011. She gave three talks in on “Posttraumatic Disorders – Concepts, Risk Factors, Thera- June 2010 at the Annual Meeting of the Associated Professional py,” sponsored by the University of Warsaw and the Polish Sleep Societies in San Antonio, Texas on "Candidate Gene Vari- Association for Cognitive and Behavioural Therapy. In Novem- ants in Relation to Sleep Homeostatic and Cumulative Neurobe- ber 2010, at the Annual Convention of the Association for havioral Responses to Chronic Partial Sleep Deprivation," Continued on page 17

www.med.upenn.edu/psych PAGE 17 www.med.upenn.edu/psych

Continued from page 16

"DQB1*0602 Allele Predicts Interindivid- Mental Health Conference in Philadel- with Severe Emotional Problems: A ual Differences in Physiological Sleep phia in October; and “Trauma Informed Meta-Model for Strengthening Cross-Sys- Structure, Sleepiness and Fatigue During Care, Balanced and Restorative Justice, tem Interventions” at the Pennsylvania Baseline and Chronic Partial Sleep Depri- and Youth Resilience” at the 2010 Penn- Community Providers Conference in vation,” and "Individual Differences in sylvania Conference on Juvenile Justice Champion, Pennsylvania in October Vulnerability to Sleep Deprivation." In in Harrisburg, Pennsylvania in Novem- 2011. July 2010, she spoke on "T3111C Poly- ber. In 2011, Dr. Hodas and his col- morphism of the Circadian Core Gene, leagues presented on “Broadening the Kyle M. Kampman, MD provided an Clock, Predicts Interindividual Differ- Scope of a Child and Adolescent Psychia- extensive summary of pharmacological ences in Affect, Sleepiness, Fatigue and trist’s Role: Systems of Care Case Con- treatments for substance use disorders, Executive Functioning During Baseline ceptualization” and on “More Alike Than with a focus on alcohol and opioid addic- and Chronic Partial Sleep Deprivation in We Think: Dilemmas Arising from tion, at the Eighth Annual Colloquium Healthy Adults" at the Annual Meeting Implementing a Systems of Care organized by the Philadelphia Psychi- of the Society for Light Treatment and Approach on Both Sides of the Border” at atric Society (PPS) in April 2010. He gave Biological Rhythms in Vienna, Austria. In the Annual Meeting of the American a talk on “Pain and Addiction” at the June 2011, Dr. Goel gave talks on "Pre- Academy of Child and Adolescent Psy- Seventh Pharmacy Focus Forum at the prohypocretin/Prepro-orexin (HCRT) - chiatry in October 2011 in Toronto. He Penn State College of Medicine in Her- 909C/T Polymorphism Predicts Individ- also spoke on “Creating a Trauma Com- shey, Pennsylvania in September 2010. ual Differences in MWT Latency, Sleep petent System in Bucks County” for the Mary Anne Layden, PhD Physiology and Homeostasis During Bucks County Behavioral Health System gave a videotaped presen- Baseline and Sleep Restriction" and on in Warminster, Pennsylvania in April; tation on "Hypersexual Dis- "Circadian CLOCK T3111C Polymor- “Trauma Informed Care in Child Wel- order," which is now used phism Associated with Individual Differ- fare” at the 19th Judicial Circuit Depend- as part of a curriculum in ences in Executive Functioning, ency Summit in Port St. Lucie, Florida in 200 Catholic parishes in Sleepiness and Mood During Sleep May; and, with colleagues, on “The Next Texas for men who have problems with Restriction" at the Annual Meeting of the Generation of Child and Adolescent Psy- sexual acting out. She spoke at the con- Associated Professional Sleep Societies in chiatrists: Promoting Youth and Family ference of the Utah Coalition against Minneapolis. In July, she spoke on “Pre- Empowerment” at the Annual Confer- Pornography in Salt Lake City in March prohypocretin/Prepro-orexin (HCRT) ence of the National Federation of Fami- 2010. Dr. Layden presented on “The Gene: Role in Mediating Individual Dif- lies for Children’s Mental Health in Pornified Life: The Damaging Conse- ferences in Daytime Sleep Propensity Washington, DC in November. quences of Pornography” at several ven- and Nighttime Homeostasis During ues in 2010 and 2011: the Anscombe Sleep Loss" at the Annual Meeting of the Steven F. Huege, MD presented on “Incorporating Home Care Training into Society in Princeton, New Jersey in April Society for Light Treatment and Biologi- 2010; the Priests for Life Canada Semi- cal Rhythms in Montreal. In October, she Geriatric Psychiatry Fellowship Train- ing” at the Annual Meeting of the Ameri- narians’ Pro-Life Congress in Ancaster, gave a talk on "Sleep and Circadian Ontario in August 2010; the Pornography Genes: Predictors for Response to Sleep can Association for Geriatric Psychiatry (AAGP) in San Antonio, Texas in March Conference sponsored by the Rucks Fam- Restriction" at the Worldsleep 2011 con- ily Foundation in Lafayette, Louisiana in ference in Kyoto, Japan. 2011. He also spoke with medical students at the University of Texas Health February 2011; and the Convergence Gordon R. Hodas, MD is a Child and Sciences Center at San Antonio on career Summit in Baltimore in April 2011. In Adolescent Psychiatrist Member of the options in geriatric psychiatry in March. March 2011, Dr. Layden gave the Presi- System of Care Youth Coalition of the Dr. Huege spoke at the Philadelphia VA dential Plenary address on “The Psychol- American Academy of Child and Adoles- Medical Center Forum on “Driver Safety ogy of the Sexual Exploitation Industry” cent Psychiatry. The Youth Coalition and Education” in September and lec- at the Annual Meeting of the American supports youth empowerment in mental tured on “Psychosis in the Elderly” at the Psychology-Law Society in Miami and health at local, state, and national levels. Department of Psychiatry’s Schizophre- spoke on “Hypersexual Disorder” at the During 2010, Dr. Hodas gave several nia Center Open House in June 2011. “That Man is You” Conference in Tampa. talks, including: “Psychotropic Medica- In addition, Dr. Layden wrote a Wither- tion for Children and Youth: Why, Marla Isaacs, PhD gave a talk on spoon Institute Monograph and a chap- When, and How?” as the Charles M. “Assessing Attachment in Young Chil- ter in the book Social Costs of Pornography. Reilly MD Endowed Lecture at Wellspan dren: Incremental Validity For Custody She gave a U.S. Congressional Briefing Health/York Hospital in York, Pennsyl- Evaluations” at the Annual Meeting of on “Pornography and Hypersexual Dis- vania in May; “Implementing Trauma the Society for Personality Assessment in order” in June 2010 and testified on Informed Care for Youth in Treatment San Jose, California in March 2010. She “Pornography and Crime” for the House and the Community” at the Annual published two papers on the topic, the Judiciary Committee of the Kansas State Meeting of the Pennsylvania Community latest in July 2011 [George C, Isaacs M Legislature in February 2011. Providers Association in Champion, and Marvin R. Incorporating attachment assessment in custody evaluations: The Caryn Lerman, PhD gave the Keynote Pennsylvania in October; “Fetal Alcohol Address at the “Frontiers in Cancer Pre- Spectrum Disorder: A State Perspective case of a two-year old and her parents. Family Court Review, July 2011]. vention Research” Conference of the on Policy and Practice Implications for American Association for Cancer Early Childhood Mental Health Practi- C. Wayne Jones, PhD presented an invit- Research (AACR) in Boson in October tioners” at the Second Annual Infant ed seminar titled “Supporting Children 2011. She spoke on “Translational Continued on page 18

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 18 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 17 Research on Nicotine Addiction Treat- University in Philadelphia in April. Cory F. Newman, PhD presented Grand ment.” Rounds at the Philadelphia VA Medical Stephen J. Morse, JD, PhD spoke to mul- Center in September 2010 on “Cognitive Deborah Anna Luepnitz, PhD gave a tiple regional, national, and international Therapy: Basic and Advanced Applica- number of invited addresses in 2010 and audiences in 2010 and 2011. Among them, tions.” He delivered a half-day lecture in 2011: “Dream Work in Psychotherapy in November 2010, he presented a paper Richmond, Virginia in October 2010 for with Couples” to the Chicago Psychoana- on neuroscience and criminal responsibili- Optima Health/ Sentara on “Taming the lytic Society in the spring of 2010; “The ty in the social science department at Swings: Cognitive Therapy for Psychology of Home and Homelessness” National Chung Keng University in Bipolar Disorder.” He presented a to the Appalachian Psychoanalytic Society Tainan, Taiwan. The next day he two-day workshop in Chexbres, in the spring of 2011; “Framing Psycho- Switzerland in December for the The memoirs of Karl Rickels, MD analysis: Time & Money from Freud to Association Suisse dePsy- were published by Notting Hill Press Lacan” as the Keynote Address to the chothérapie Cognitive (ASPCo) on in July 2011. The book – A New Directions in Psychoanalysis Confer- the topic of “Cognitive Therapy Serendipitous Life: From German ence in Washington, DC in the spring of Supervision and Training.” In 2011; “Psychoanalysis and the Treatment POW to American Psychiatrist – chronicles his extraordinary life and March 2011, Dr. Newman deliv- of Homeless Adults” to the World Con- ered three days of training at Highlands ference on Psychotherapy in Sydney, Aus- times and his pioneering role in the creation and evolution of the field of Behavioral Health in Littleton, Colorado tralia in August 2011; “How on “Cognitive Therapy for Inpatients.” In Psychoanalysis Matters to Poor and psychopharmacology. Dr. Rickels came to Penn as a resident in psychia- October, he presented two days of lec- Homeless Patients” (with Elizabeth tures and an evening’s clinical supervi- Danto) to the Spring 2011 meeting of Divi- try in the 1950s and later founded the Mood and Anxiety Disorders Section in sion roundtable on the topic of “Cognitive sion 39 of the American Psychological Behavior Therapy for Severe Mood Disor- Association in New York in April; “The the Department of Psychiatry. During a career extending over five decades ders and Suicidality” at the invitation of Clinical Relevance of Winnicott and the Associacao de Terapias Cognitivas do Lacan” at the Austen Riggs Center in and continuing today, Dr. Rickels has earned an international reputation as Esatado do Parana, in Curitiba, Brazil. In Stockton, Massachusetts in November November 2011, he conducted a Master 2011; and “Lacan and the Question of one of the world’s leading scientists focused on the development of new Clinician Seminar on the topic of “Artistic Desire” at an Invited Panel on “Desire” at Adherence: Maximizing ‘Flex’ while Mini- the American Psychoanalytic Association drug treatments for mental illness, particularly anxiety disorders. The book is mizing ‘Drift’ in Conducting Competent in January 2012. Dr. Luepnitz also taught Cognitive-Behavioral Therapies” and took a Master Class on “Dreams” at the St. available for purchase at http://www.amazon.com/. part in a Clinical Roundtable on “Defin- Louis Psychoanalytic Society in ing, Assessing, and Fostering Therapist April 2011 and presented a day- Competence” at the Annual Convention long seminar on “Psychotherapy of the Association of Behavioral and Cog- with Couples” at the University gave the Keynote nitive Therapy in San Francisco. Also, in of New South Wales in August Address, “Lost in Trans- June 2011, Dr. Newman gave his 16th 2011. Dr. Luepnitz continues to lation?: An Essay on Law annual piano recital at Dunlop Auditori- direct a pro bono program and Neuroscience,” at a um, featuring the Franz Liszt piano tran- called I.F.A. (Insight For All), conference on Law and scription of the 2nd movement of Ludwig which she launched in 2005. Neuroscience, the first van Beethoven’s 9th Symphony and I.F.A. connects psychotherapists ever in Taiwan, spon- Guido Agosti’s piano transcription of Igor in the community willing to work with sored by the Medical School of National Stravinsky’s Firebird Suite. homeless patients. Taiwan University in Taipei. In April 2011, he delivered the Keynote Address, Charles P. O’Brien, MD, PhD gave a ple- Cathy A. Mercaldi MD gave Pediatric “A Plea for Neuromodesty,” at a confer- nary lecture on “Advances in the Under- Grand Rounds (with Kim Cover, MS, RD, ence titled “Technologies on the Stand: standing and Treatment of Addictive CSSD, LDN) on “Eating and Exercise Dis- Legal and Ethical Questions in Neuro- Disorders” at the 15th World Congress of turbances” at Cooper Children’s Regional science and Robotics.” The conference Psychiatry in Buenos Aires, Argentina in Hospital/Robert Wood Johnson Medical was sponsored by the Institute for Law, September 2011. School at the University of Medicine and Society and Technology (TILT) and was Dentistry of New Jersey in Camden, New held at Tilburg University in the Nether- Helen M. Pettinati, PhD organized and Jersey in March 2011. They gave the same lands. In October in New York City, Dr. chaired a symposium entitled “Extended- talk for “Speak up for Kids,” sponsored Morse gave the Keynote Address on neu- Release Naltrexone for Alcohol Depend- by the Child Mind Institute, the American roscience and criminal responsibility to ence: From Clinical Research to Clinical Academy of Child and Adolescent Psychi- the Annual Meeting of the Forensic Divi- Practice” at the Annual Meeting of the atry, and Parents Magazine, at Medical sion of the New York State Psychological Research Society on Alcoholism in San Rounds at Society Hill Pediatrics in Association. He delivered the Keynote Antonio, Texas in June 2010. She spoke at Philadelphia in May. Dr. Mercaldi also Address on addiction and criminal the symposium on the “Efficiency of spoke on “Eating Disorders in Children responsibility at a conference on “Addic- Extended-Release Naltrexone Based on and Adolescents and their Treatment” to tion and Agency,” sponsored by the Cen- the Severity of Alcohol Dependence” and the Division of Child and Adolescent Psy- ter for the Study of Mind in Nature at also gave a talk on the “Problems in chiatry in the Department of Psychiatry Oslo University in Norway in November. Assessment and Treatment of Co-Occur- and Human Behavior at Thomas Jefferson ring Depression and Alcohol Depend- Continued on page 19

www.med.upenn.edu/psych PAGE 19 www.med.upenn.edu/psych

Continued from page 18

ence” as part of a satellite workshop enti- tured speakers at the 3rd annual ADHD Gables, Florida, and he spoke on “Psycho- tled “Pharmacological Treatment of Alco- Aware Symposium held at Bucks County logical Issues Before and After Bariatric hol and Co-Occurring Psychiatric Community College in Newtown, Penn- Surgery” at the 59th Annual Clinical Disorders: What Do We Know, and sylvania in September 2011. Meeting of the New Jersey Chapter of the Where Do We Go From Here?” In July American College of Surgeons in Decem- 2011 at the New York Psychiatric Institute David B. Sarwer, PhD presented a number 2010 in Woodbridge, New Jersey. In at Columbia University, Dr. Pettinati was ber of continuing medical education talks March 2011, he gave a talk on “Behavioral an invited Grand Rounds speaker. Her and courses in 2010 and 2011. Among Issues in Weight Management” at the lecture was titled “Depression and Alco- them, he spoke on “Psychological Issues Comprehensive Multi-Disciplinary hol Dependence: Problems in Assessment Before and After Bariatric Surgery” and Approaches to Weight Management Con- and Treatment.” served as Co-Course Director of the “Mas- ference held at the JFK Medical Center in ters Course in Behavioral Health” at the Edison, New Jersey. J. Russell Ramsay, PhD Annual Meeting of the American Society presented a workshop for Metabolic & Bariatric Surgery Robert A. Schnoll, PhD titled “Nonmedication (ASMBS) in June 2010 in Las Vegas. He gave invited talks on Treatments for Adult also served as Co-Course Director of the “Studies of Treatments ADHD” at the conference same course at the meeting of the ASMBS for Nicotine Dependence” of the American Psycho- in June 2011 in Orlando, Florida. He gave at the National Drug logical Association in Toronto in August a talk on “Psychological Aspects of Dependence Center at the 2009, and gave invited lectures in Septem- Extreme Obesity and Bariatric Surgery” at All India Institute of Med- ber 2009 in Sweden (Malmö and Stock- the Central Mississippi Medical Center ical Sciences in New Delhi in April 2011; holm) on an “Overview of Adult ADHD” Obesity Meeting in August 2010 in Jack- on “Improving Treatments for Nicotine and “Cognitive Behavioral Therapy for son, and on “Psychosocial and Behavioral Dependence” at the Temple University Adult ADHD.” Dr. Ramsay and other Strategies to Optimize Outcomes” at the School of Public Health in Philadelphia in members of the Penn Adult ADHD Treat- Bariatric Summit 2010 in September 2010 April 2011; and on “Quitting Smoking ment and Research Program were co- in Charleston, South Carolina. In October 101” in Philadelphia in November 2011 as authors of a paper presented by Anthony 2010, he spoke on “Psychological and part of CANPrevent Lung Cancer, a pre- L. Rostain, MD, MA at a symposium at Behavioral Aspects of Bariatric Surgery” vention series sponsored by Penn's the 3rd International Congress on ADHD at the Westchester Medical Center Obesity Abramson Cancer Center. held in Berlin, Germany in May 2011. Retreat in Westchester, New York, and on Clinical outcomes of individuals receiving “Assessing Psychiatric Readiness: Body Andrew A. Strasser, PhD served as an either combined or individual treatments Dysmorphic Disorder” at the meeting of expert on the dangers of cigarette smok- for adult ADHD were discussed during the American Society of Plastic Surgeons ing at the Lung Cancer “Meet the the symposium, which was titled “Next in Toronto, Canada. Dr. Sarwer gave a Experts” Day in October 2011 in Philadel- Steps Towards Empirically Supported course titled “Psychology 101 for the phia. Psychosocial Treatments for Adult Bariatric Professional” at a meeting of the Richard F. Summers, MD gave courses ADHD.” Dr. Ramsay was one of the fea- ASMBS in November 2010 in Coral on “Evidence-Based Psychodynamic Ther- Continued on page 20

~~IN MEMORIAM~~

Arthur I. Alterman, PhD, Research Professor of Psychology in Psychiatry in the Perelman School of Medi- cine, passed away on October 5, 2011. Dr. Alterman had a long and distinguished career in substance abuse research at VA medical centers, Thomas Jefferson University, the University of Pittsburgh, and the University of Pennsylvania. The last 27 years at the Philadelphia VA Medical Center and Penn’s Center for Studies of Addiction were his most productive, and most meaningful to him. Through work supported by the NIH and the VA, he dedicated his career to examining substance abuse treatment to make it better, to developing measures to better assess the issues of the patients served, and to understanding who will do well in treatment and who needs more or different care to do better. This work yielded new insights into substance abuse treatments and patients, and resulted in changes in assessing patients and the care they were provided. Noteworthy in all his work was the rigor with which it was conducted and the precision in how it was presented. The volume and breadth of his research achievements are only partially reflected in hundreds of scientific publications. He mentored numerous now nationally and internationally recognized scientists, and his research itself opened new avenues that countless others have pursued. Personally, he made all of those with whom he collaborated feel appreciated; professionally, he made their work better. He gave freely of himself, and imparted invaluable knowledge and experience. His honesty, integrity, and high standards were always evident and served as a model for colleagues to emulate. As his work continues to have an impact, greater will be the impact of those he touched who will follow. To all that knew him, he was unique in so many ways which made him such a refreshing character, but above all, he demonstrated great character. His legacy and our memories will persist. Still our loss is profound. The Department extends its deepest condolences to Dr. Alterman’s wife Joan and his son David. (We thank John S. Cacciola, PhD for contributing to this memorial.)

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 20 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 19 apy” at the American Psychiatric Associa- lytic Society and Institute in March 2011; George E. Woody, MD spoke to multiple tion in May 2010; World Congress of Psy- “Learning Psychodynamic Therapy in the regional, national, and international audi- chotherapy in Lucerne, Switzerland in 21st Century” at the Arkin Mentrum ences in 2010 and 2011. Among his many June 2010; American Psychological Asso- Kliniek in Amsterdam, Netherlands in talks, he presented on “Data Points the ciation in August 2010; American Psychi- March 2011; “Positive Psychology and Way: Medication Assisted Therapy for atric Association in May 2011 (seminar); Psychodynamic Therapy: Positive Emo- Reducing Drug Use, HIV Risk and Man- American Psychological Association in tion, Negative Emotion and Complexity” aging HIV Infection in Opioid Addicted August 2011; and a workshop in Tel to the Second World Congress of Positive Patients” in June 2010 to the Regional Aviv, Israel in December 2011. Dr. Sum- Psychology in August 2011; and “Learn- Meeting of the World Psychiatric Associa- mers also delivered invited talks at a ing Psychodynamic Therapy in the 21st tion in St. Petersburg, Russian Federation. number of conferences, including - “Posi- Century” at Reading Hospital and Med- In July 2010, he spoke in Jakarta, Indone- tive Psychology and Psychodynamic ical Center Grand Rounds in October sia on “Medication Assisted Therapy in Therapy” to the European Conference on 2011. Addiction Treatment” at a talk sponsored Positive Psychology in Copenhagen, Den- by the Lido Treatment Center of the mark in June 2010; “If Freud Could Twit- Kenneth J. Weiss, MD National Narcotics Board, the RSKO ter: Learning Psychodynamic Therapy in spoke on “Assessing Capaci- Treatment Center, and the Department of the 21st Century” at University of Wis- ty in the Older Adult” to the Psychiatry at the University of Indonesia. consin Psychiatry Grand Rounds in Octo- American Society on Aging In November 2010, Dr. Woody delivered ber 2010, at the Adam Cornell Major in Philadelphia in September a talk on “New Developments in Medica- Teachers in Psychotherapy Lecture at 2010, and presented on tion Assisted Therapies (MAT) for Addic- McLean Hospital in March 2011, and at “Hoarding and the Older Adult” to the tion Treatment” at the Annual Meeting of University of Louisville Psychiatry Grand College of Physicians of Philadelphia in the HIV Prevention Treatment Network Rounds in April 2011; “The General Psy- November 2010. He delivered a paper on (HPTN) in Atlanta and, in October 2011, chiatry CSV as an Educational Opportu- “Autism Spectrum Disorder and Criminal he spoke on “Naltrexone for Treating nity” to the American Association of Justice” at the Annual Symposium of the Amphetamine Dependence?” at a meet- Directors of Psychiatry Residency Train- American College of Forensic Psychiatry ing of the American Society of Addiction in March 2011 in San Diego. Dr. Weiss ing in March 2011; “Insight in Practice, Medicine (ASAM) in Washington, DC. Practicing Insight: Change in Psychody- also gave a paper on “Isaac Ray’s Jeffer- namic Therapy” to the Boston Psychoana- son Lectures” to the American Osler Soci- ety in Philadelphia in May 2011.

DEPARTMENT OF PSYCHIATRY ANNUAL FAMILY PICNIC

July 16, 2011

www.med.upenn.edu/psych PAGE 21 www.med.upenn.edu/psych

RESEARCH NEWS

Beginning in January 2009, the Department of Psychiatry has posted on its website reference information for faculty journal articles published each month. The citations are obtained from PubMed. Please visit www.med.upenn.edu/psych/articles.html for these listings.

Janet E. Audrain-McGovern, PhD hand with these individuals on a daily can mothers with depressive disorders received two grants from the National basis. had similar rates of anxiety symptoms Institute on Drug Abuse (NIDA). One and suicidal ideation, but lower levels of grant will examine the role of smoking in A recent Penn study, led by Steven J. depressive symptoms, than other sam- positive affect and reward regulation in Berkowitz, MD, showed that following a traumatic event, early intervention depression-prone smokers and the sec- Department of Psychiatry Plays ond grant will use a behavioral economic reduces the odds of PTSD in children by framework to determine the substi- 73 percent. The intervention is called the Lead Role in DSM Trials tutability of physical activity for smok- Child and Family Traumatic Stress Inter- ing. vention (CFTSI). The study appears online and in print in the Journal of Child Mahendra T. Bhati, MD led the field Mathias Basner, MD, PhD, MSc Psychology and Psychiatry. trials at Penn to test proposed diagnos- received a four-year research grant titled tic criteria and measures for the Amer- “Individualized Real-Time Neurocogni- Olivier Berton, PhD received a three- ican Psychiatric Association's (APA) tive Assessment Toolkit for Space Flight year 2010 International Mental Health fifth edition of the Diagnostic and Sta- Fatigue.” The grant, which runs from Research Organization (IMHRO) Rising tistical Manual of Mental Disorders October 2011 until September 2015, was Star Award. Chang-Gyu Hahn, MD, (DSM-5). Penn was only one of seven awarded by the National Space Biomed- PhD is Co-Principal Investigator on this adult field trial sites, and only one of ical Research Institute (NSBRI). Its goal is project titled “Evaluation of HDAC6 as a eleven sites overall. Data was collect- to develop neurocognitive tests for the Resilience Biomarker and a New Thera- ed from over 600 patients seen in the International Space Station. (For details, peutic Target for Antidepressants.” This Outpatient Psychiatry Clinic. Dr. Bhati please visit translational study will evaluate HDAC6 and his team worked with patients to http://www.nsbri.org/projects/indivProject.as as a possible stress regulating enzyme assess proposed diagnostic criteria p?id=419&projID=288.) and resilience biomarker in depressed related to general anxiety disorder, and PTSD patients. The IMHRO is an obsessive compulsive disorder (OCD) Aaron T. Beck, MD and lead author Paul international charity committed to fund- and hoarding, anxious depression, and M. Grant, PhD had a paper published ing research and raising awareness to binge eating disorders, together with reporting the results of a randomized help people with brain disease, and, ulti- personality disorders. The evaluation controlled trial designed to investigate mately, find cures for schizophrenia, was designed to answer several ques- the effectiveness of a new cognitive- depression, and bipolar disorder. Dr. tions. Are the proposed diagnostic behavioral protocol based on advances in Berton was also awarded a new R01 criteria and measures easy for clini- the basic understanding of negative grant from the National Institute of Men- cians to understand and to use? Do symptoms and poor functioning in schiz- tal Health (NIMH) titled "Role of HDAC6 they accurately describe patients’ psy- ophrenia. The protocol was adapted for in a Murine Model of Affective Disorder chiatric problems and help clinicians neurocognitive impairment and low and Antidepressant Action." This grant make decisions about treatment plans? insight into delusions and hallucinations. characterizes a novel therapeutic target Are the same conclusions reached The study found that cognitive therapy for depression using new animal models. can be successful in promoting clinically consistently when the criteria are used meaningful improvements in functional Rhonda C. Boyd, PhD co-authored a by different clinicians? How well do outcome, motivation, and positive symp- paper, which demonstrated that the life- the diagnostic criteria reflect the men- toms in low-functioning patients [Grant time prevalence of mood disorders is tal disorders they are designed to P, Huh GA, Perivoliotis D, Stolar NM, & higher for white mothers than for both describe? The field trials also tested Beck AT. Randomized trial to evaluate African American and Caribbean black new tools designed to help clinicians the efficacy of cognitive therapy for low mothers. Among other findings, the evaluate the severity of symptoms and functioning patients with schizophrenia. study reported that African American measure whether patients are improv- Arch Gen Psychiatry 69(2): 121-7, 2011]. In mothers with higher education levels and ing over time. DSM-5 is scheduled to addition, Dr. Beck received a grant white mothers who became parents as be released in May 2013. (For more award titled “Intensive Cognitive Thera- teenagers are more likely to have a life- information, see www.dsm5.org.) py (CT) Training for Case Managers in time mood disorder [Boyd RC, Joe S, Safe Havens” from the Van Ameringen Michalopoulos L, Davis E, Jackson JS. Foundation. The goal of this intensive Prevalence of mood disorders and mental ples of offspring of mothers with depres- training effort is to increase the accessi- service use among U.S. mothers by race sion [Boyd RC, Diamond GS, Ten Have bility of effective CT interventions to and ethnicity. J Clin Psychiatry 72(11): TR. Emotional and behavioral function- individuals experiencing chronic home- 1538-1545, 2011]. Dr. Boyd co-authored ing of offspring of African American lessness by providing intensive trainings another paper, which showed that mothers with depression. Child Psychiatry to the case managers who work hand-in- school-aged children of African Ameri- Human Dev 42: 594-608, 2011]. Continued on page 22

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 22 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 21

Gregory K. Brown, PhD is subjects. the Principal Investigator on Studying the Biological Mechanisms an R01 grant from the Sumedha Chha- of Addiction Relapse National Institute of Mental tre, PhD, a Lec- turer within the Health (NIMH) titled “Cog- Anna Rose Childress, PhD is the Principal HIV Prevention nitive Therapy for Suicidal Investigator on a CURE research grant (Com- Research Division, Older Men.” The primary aim of this ran- monwealth Universal Research Enhancement received her first domized controlled trial is to compare the Program) from Pennsylvania's Department of NIH research grant titled “Can- efficacy of cognitive therapy with the effi- Health to study the biological mechanisms of cer Care in Medicare HIV.” The cacy of an enhanced usual care interven- addiction relapse that may be common across objective of this R21 grant is to tion for reducing the rate of suicide drugs of abuse, including cocaine, marijuana, assess the incidence and preva- ideation for older men. and prescription opioids. The project, a joint effort lence rates of non-AIDS defining of Penn, Lincoln University, and the Philadelphia Gregory Carlson, PhD led a study report- cancers and the associated mor- VA Medical Center, is titled "A CURE Addiction ed in the Proceedings of the National Acade- tality rates, and determine the Center of Excellence: Brain Mechanisms of my of Sciences, which used incremental burden of non-AIDS Relapse and Recovery" and runs through May electrophysiological, anatomical, and defining cancers on health 2015. The study is the first large-scale effort in immunohistochemical approaches – and resource utilization and cost in the nation to link brain measures with drug use high-speed imaging – to understand how Medicare HIV/AIDS patients. outcomes in a large cohort of underserved schizophrenia works at the cellular level. individuals being treated for addiction. By learn- Dr. Carlson explained in a Penn Medicine Paul F. Crits-Christoph, PhD ing more about the underlying causes of vulnera- press release, "Our work provides a model received an R01 research award from the National Institute of bility to relapse, investigators aim to generate linking genetic risk factors for schizophre- knowledge that will ultimately help produce treat- nia to a functional disruption in how the Mental Health (NIMH) to study the mechanisms of psychothera- ments to permanently alter the harsh relapse sta- brain responds to sound, by identifying tistics for addiction – nearly 80 percent relapse reduced activity in special nerve cells that py treatments for depression in community settings. by six months after treatment. Brain imaging are designed to make other cells in the technologies will be used to learn more about brain work together at a very fast pace. Guy S. Diamond, PhD is Princi- how the brain responds to smoking and addictive We know that in schizophrenia this ability pal Investigator on a National drugs. Charles P. O'Brien, MD, PhD and is reduced, and now, knowing more about Institute of Mental Health Ronald N. Ehrman, PhD are Co-Investigators, why this happens may help explain how (NIMH) grant titled “Attach- and each of the individual drug studies has a PI loss of a protein called dysbindin leads to ment Based Family Therapy for that component – Cocaine (Anna Rose Chil- some symptoms of schizophrenia." Three (ABFT) for Youth with Suicidal dress, PhD); Marijuana (Teresa R. Franklin, labs at the Perelman School of Medicine Ideation.” The study is a ran- PhD); and Prescription opioids (Daniel Langel- worked on the project [Carlson GC, Talbot domized clinical trial comparing ben, MD). K, Halene TB, Gandal MJ, Kazi HA, ABFT to non-directive support- Schlosser L, Phung QH, Gur RE, Arnold ive therapy for treating youth SE, Siegel SJ. Dysbindin-1 mutant mice with elevated suicide ideation and depres- National Research Council of the National implicate reduced fast-phasic inhibition as sion. The five-year grant runs until Sep- Academies. a final common disease mechanism in tember 2016. In addition, Dr. Diamond Newell Fischer, MD is the author of a schizophrenia. Proc Natl Acad Sci USA received a grant titled "Youth Suicide Pre- newly published book, Nine Lives: A View 108(43): E962-70, 2011]. Dr. Carlson also vention in Primary Care (YSP-PC)" from From Within. Vantage Press published the received a one-year pilot grant from the the federal Substance Abuse and Mental volume in the fall of 2011. He also Penn Institute on Aging to pioneer a Health Services Administration (SAMH- authored an article titled "Mother-Infant mechanistic understanding of how insulin SA) to extend ongoing work in Pennsylva- Attachment: The Demystification of an resistance leads to cognitive decline in nia focused on helping primary care Enigma" in the book The Mother and Her aging. providers (PCPs) to identify and treat Child: Clinical Aspects of Attachment, Separa- Stanley N. Caroff, MD is Principal Inves- and/or properly refer youths at risk for tion, and Loss, edited by Salman Akhtar, tigator on three research grants from the suicide. The project focuses on training, MD. The book was published in Novem- National Institute for Mental Health web-based behavioral health screening, ber 2011 by Jason Aronson, Inc. (NIMH): 1) “A Comparison of Long-acting and linking the PCP patients with mental Teresa R. Franklin, PhD is the Principal Injectable Medications for Schizophrenia health services. It is being implemented in Investigator on two recent grants: 1) “Use (ACLAIMS)” (2010-2014); 2) “Human partnership with Pennsylvania's Depart- of SPECT and Perfusion fMRI to Examine Genetics Initiative: A Comparison of ment of Public Welfare. the Role of DAT Genotype in Motivated Long-Acting Injectable Medications for David F. Dinges, PhD was a member and Smoking Behavior” from the DANA Schizophrenia (ACLAIMS-HGI)” (2010- writing contributor to “The Effects of Foundation, which runs through June 2014); and 3) “Evaluation of a Cognitively Commuting on Pilot Fatigue” (2011). The 2012; and 2) “Characterizing a Cue-Vul- Adaptive e-treatment in Schizophrenia document was produced by the Commit- nerable Pharmaco-Responsive Endophe- Diagnosed Adults: A Remediation-based tee on the Effects of Commuting on Pilot notype in Smokers” from the National Approach (eCAeSAR)” (2011-2013). Each Fatigue, which was established by the Institute on Drug Abuse (NIDA), which study will access the NIMH’s Schizophre- Board on Human-Systems Integration runs through November 2015. The NIDA nia Trials Network (STN), which provides within the Division of Behavioral and grant is Dr. Franklin’s first R01 grant as PI. infrastructure for recruiting and testing Social Sciences and Education of the Continued on page 23

www.med.upenn.edu/psych PAGE 23 www.med.upenn.edu/psych

Continued from page 22

Namni Goel, PhD had a paper pub- and often complex psychiatric syn- ate a novel neurocognitive training inter- lished discussing the role of the dromes of older adults. The award is vention for the treatment of nicotine DQB1*0602 Allele in predicting individ- sponsored by the U.S. Department of addiction and evaluate the neurobehav- ual differences in response to sleep loss. Health and Human Services’ Health ioral mechanisms of effect using neu- The paper was the subject of an editorial Resources and Services Administration roimaging. Dr. Lerman also published in the journal Neurology. [Goel N, Banks (HRSA) and is titled “A Plan for Achiev- the first evidence linking a common S, Mignot E, Dinges DF. DQB1*0602 pre- ing Leadership in the Fields of Geriatric polymorphism in the mu opioid receptor dicts interindividual differences in physi- Psychiatry and Interdisciplinary Educa- (OPRM1) gene with receptor binding ologic sleep, sleepiness and fatigue. tion.” availability in the human brain using Neurology 75: 1509-1519, 2010]. She is also positron emission tomography (PET). Principal Investigator on a grant from John B. Jemmott III, PhD is Principal The study, reported in the Proceedings of the Office of Naval Research titled “Phe- Investigator on an NIH grant from the the National Academy of Sciences, also notypic and Genotypic Markers of Per- National Center for Minority Health and related receptor availability to the formance Vulnerability to Sleep Loss.” Health Disparities titled “Reality Check rewarding effects of smoking. This The grant will run through March 2016. in Transit: Evaluation of a Serial Drama paper identified a gene-brain-behavior for Black Youth.” The goal is to evaluate relationship that helps to clarify the Raquel E. Gur, MD, PhD received $10.1 the impact of the Centers for Disease nature of nicotine addiction and the abil- million in total funding ($5.1 million in Control (CDC)-developed serial drama ity to quit smoking. FY2010) for a Grand Opportunity grant intervention, “Reality Check,” on HIV titled “Neurodevelopmental Genomics: testing rates among African American Irwin Lucki, PhD received a new R01 Trajectories of Complex Phenotypes” youth, 14 to 24 years of age. The inter- grant from the National Institute of Men- (RC2 – MH-089983). The grant was fund- vention is particularly innovative tal Health (NIMH) titled "Regulation of ed through the American Recovery and because the serial drama will be shown Neurogenesis by Stress and Antidepres- Reinvestment Act (ARRA). This grant, in on public buses. The project began in sants." The grant investigates changes in collaboration with investigators at the June 2011 and runs through May 2012. hippocampal neurogenesis and brain- Children’s Hospital of Philadelphia derived neurotrophic factor (BDNF) by (CHOP), started on October 1, 2009. She A book authored by C. chronic antidepressant treatments in later received a supplement to this Wayne Jones, PhD, Setting mice. Studies also compare the role of award. the Stage for Change: In- environmental stress and genetic back- Home Family Based Treat- ground as regulators of the response to Ruben C. Gur, PhD received a research ment, was published in antidepressant drug treatments. grant jointly funded by the NIH and the July 2010. This book serves Army Study to Assess Risk and as a treatment manual that operational- Stephen J. Morse, JD, PhD authored Resilience in Service members (Army izes the Eco-Systemic Structural Family many papers and book chapters during STARRS) titled “Modifiable Risk and Therapy approach used in Pennsylva- 2010 and 2011. Of particular note, his Protective Factors for Suicidal Behaviors nia’s Family-Based Mental Health Servic- paper on “Mental Disorder and Criminal in the US Army.” Army STARRS is the es (FBMHS) programs. FBMHS is Law” was published in the Journal of largest study of mental health risk and designed to prevent hospitalization or Criminal Law and Criminology (Vol. 101, p. resilience ever conducted among military out-of-home placement of a child or ado- 885, 2011). This major article was an personnel. Dr. Gur also received funding lescent with emotional disturbances. invited contribution to the 100th anniver- from the NIH and the Department of sary symposium issue of the journal. It Veterans Affairs for a project that is part Vidyulata Kamath, PhD, a post-doctoral reviews the current state of the law of the “Marine Resiliency Study (MRS- fellow in the Neuropsychiatry Section, reflected in U.S. Supreme Court cases to II).” This study seeks to answer the ques- received a junior investigator grant titled discuss when special treatment is justi- tion why some Marines develop “Neuropsychological Probes of fied for criminal defendants with mental post-traumatic stress disorder (PTSD) Orbitofrontal Dysfunction” from the disorders. The underlying thesis of the and others do not. American Psychological Association. paper is that people with mental disor- Sangwon F. Kim, PhD received a der should, as far as is practicable and Chang-Gyu Hahn, MD, PhD was one of consistent with justice, be treated just 42 researchers who were awarded 2010 NARSAD Young Investigator Award in 2010. His project is titled “Validation of a like everyone else, but there are excep- Independent Investigator grants from the tions to this general principle when National Alliance for Research on Schiz- Therapeutic Target to Intervene AAPDs- Mediated Obesity in a Cell Model.” defendants substantially lack rational ophrenia and Depression (NARSAD). capacity. Dr. Hahn will study the NMDA receptor David Leitman, PhD in the Neuropsy- in the prefrontal cortex of the brain to chiatry Section received an NIH K08 Cory F. Newman, PhD completed and identify possible targets for novel thera- research grant titled “Multimodal Neu- submitted a draft of a new book titled peutics for schizophrenia patients. roimaging of Prosody in Schizophrenia Core Competencies in Cognitive-Behavioral and Developmental Disorders.” Therapy: Becoming a Highly Effective Cog- Steven F. Huege, MD received a five- nitive-Behavioral Therapist. The volume is year Geriatric Academic Career Award Caryn Lerman, PhD received a new R01 scheduled to be published by Routledge to invent and develop curricula and research grant from the National Insti- in the summer of 2012. didactic experiences that most effectively tute on Drug Abuse (NIDA), with James train young physicians and other health Loughead, PhD and Ruben C. Gur, David W. Oslin, MD received a VA care providers in the evaluation, under- PhD, to conduct a clinical trial to evalu- Merit Award for a study titled “Treat- standing, and management of common ment of PTSD and Addictions.” Continued on page 24

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 24 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 23

Helen M. Pettinati, PhD is the Center occurring depression and alcohol addic- brain-derived neurotrophic factor tran- Director and Principal Investigator (PI) for tion [Pettinati HM, & Dundon WD. scription in the rat medial prefrontal cor- a National Institute on Drug Abuse Comorbid depression and alcohol tex, which alters the reinforcing efficacy of (NIDA) Center grant titled "Innovative dependence: New approaches to dual cocaine. Journal of Neuroscience 30: 11735- 11744, 2010; and Schmidt HD, Sangrey GR, Darnell SB, Schassburger RL, Cha J-H Completion of Historic Space Simulation Study J, Pierce RC, and Sadri-Vakili G. Increased BDNF expression in the ventral tegmental David F. Dinges, PhD and Mathias Basner, MD, PhD, MSc recently completed area during cocaine abstinence is associat- data acquisition in a historic space simulation study in Moscow. They were the sole ed with increased histone acetylation at U.S. investigators being supported by the National Space Biomedical Research BDNF exon I-containing promoters. Jour- Institute (NSBRI) to monitor neurobehavioral and psychosocial functions of the 6- nal of Neurochemistry, in press]. man international crew (3 Russians, 2 Europeans, 1 Chinese) undergoing a 520- J. Russell Ramsay, PhD had a book, Non- day simulated space mission to Mars. The project was initiated by the Russian Medication Treatments for Adult ADHD, Academy of Sciences and its Institute for Biomedical Problems (IBMP), which built published by the American Psychological a chamber that simulates prolonged human confinement of the kind that will occur Association in 2010. The book received a during a mission to Mars. The IBMP 520-day Mars simulated mission is historic for perfect review score (100/100) from Med- two reasons: 1) it is the longest simulated space mission yet attempted, and 2) it InfoNow, a literature and review service marks the first time that Russia, Europe, the US, and China have collaborated in a for health care professionals. space flight simulation. The mission began with hatch closing on June 3, 2010, and ended with hatch opening on November 4, 2011. During the simulated mission, the Karl Rickels, MD and Irwin Lucki, PhD crew undertook tasks similar to those that would occur on a real mission to Mars. led investigators in the Department of Using special computer technology and software, Dr. Dinges and collaborators Psychiatry for more than a decade to measured sleep-wake cycles, PVT (Psychomotor Vigilance Test) performance, study pharmacologically and then test moods, conflicts, and emotional expressions of crew members throughout the mis- clinically a new treatment for depression. sion. They concluded the study with data acquisition more than 99 percent com- The drug (vilazodone) became the first plete for all measures (i.e., more than 850 assessment batteries completed and new medicine to treat depression in more over 73,000 hours of sleep-wake actigraphy acquired). NSBRI, NASA, and the than a decade when it received FDA Russian Space Agency have noted the exceptional data intake from the study and approval in January 2011. proposed it for a model going forward. Drs. Dinges and Basner will present the results at a meeting in Moscow in April 2012. Robert L. Sadoff, MD had two books published. The first, in 2010, is Ethical Issues Approaches for Cocaine Pharmacothera- therapy challenges and progress. Psychi- in Forensic Psychiatry: Mini- py" and also for one of the component atric Times 28(6): 49-55, 2011]. Dr. Pettinati mizing Harm by Wiley (Lon- projects: “Extended-Release Naltrexone and Margaret Mattson, PhD from the don). He spoke about the book on and Topiramate Combined for the Treat- NIAAA produced a web version of a November 1, 2011 at the University of ment of Cocaine and Alcohol” (2- brief, generic medical management manu- Pennsylvania Law School under the aus- P50DA012756-11). She is also the PI for a al for providing pharmacotherapy as part pices of the Scattergood Program for the National Institute on Alcohol Abuse and of the treatment for alcohol dependence Applied Ethics of Behavioral Care. The Alcoholism (NIAAA) grant titled “A [Pettinati HM, & Mattson ME. Medical second book, in 2011, is titled Handbook of Phase 2, Double-Blind, Placebo Controlled Management Treatment Manual: A Clini- Forensic Assessment: Psychological and Psy- Trial to Assess the Efficacy of Levetirac- cal Guide for Researchers and Clinicians chiatric Perspectives by Wiley etam Extended Release in Very Heavy Providing Pharmacotherapy for Alcohol (New York). Dr. Sadoff is one Drinkers” (NCIG-002) and the PI for Dependence (Generic Version: 2010 edi- of four editors and author of another NIAAA grant titled “A Phase 2, tion) (http://pubs.niaaa.nih.gov/publications/ seven chapters in this text- Double-Blind, Placebo Controlled Trial to Medical Manual/MMManual.pdf)]. book. Dr. Sadoff is also co-edi- Assess the Efficacy of Varenicline Tartrate tor of a 2011 book edited by his for Alcohol Dependence in Very Heavy R. Christopher Pierce, PhD has an ongo- wife, Joan H. Sadoff, titled Drinkers” (NCIG-003). Dr. Pettinati and ing National Institute on Drug Abuse Pieces from the Past: Voices of William Dundon, PhD together pub- (NIDA)-funded collaboration with Ghaza- Heroic Women in Civil Rights by lished a brief review article that included leh Sadri-Vakili, MD, PhD from Har- Bookmobile Press (Minneapo- a summary of the finding from a double vard/MGH. This collaboration has lis). In addition, he is editing a special blind, placebo-controlled trial that two produced two significant research papers, issue of the Journal of Psychiatry and Law, medications, an antidepressant and an among the first reports to demonstrate highlighting the forensic programs at the anti-craving medication (in particular an that chromatin remodeling plays a signifi- University of Pennsylvania, showing the opiate antagonist), together are better than cant role in cocaine-induced behavioral depth and breadth of the forensic pro- either medication alone for treating indi- plasticity [Sadri-Vakili G, Kumaresan V, grams in psychiatry, neuroimaging, psy- viduals with both major depression and Schmidt HD, Famous KR, Chawla P, Dar- chology, nursing, criminology, law, alcohol dependence. The article under- nell SB, Vassoler F, Muhammad SI, Xia E, addiction psychiatry, geriatric psychiatry, scored the importance of the study’s Overland RP, Bass CE, Terwilliger EF, consultation and liaison psychiatry, and results in bringing the field one step closer Pierce RC, and Cha J-H J. Cocaine- child psychiatry. to finding best practices in treating co- induced chromatin remodeling increases Continued on page 25

www.med.upenn.edu/psych PAGE 25 www.med.upenn.edu/psych

Continud from page 24

Heath D. Schmidt, PhD existing R01 grant to investigate the effect tive impairment, including early decline received a K01 award from of banning menthol in cigarettes on smok- known as mild cognitive impairment. the National Institute on Drug ing behaviors and toxin exposures; and 3) Abuse (NIDA) to assess the an NCI R01 grant (with Ian Blair, PhD in Amy Wenzel, PhD had two epigenetic mechanisms under- the Department of Pharmacology) to books published in 2011: lying cocaine-induced increas- study the genetic susceptibility to lung Anxiety in Childbearing es in BDNF levels in the limbic system. cancer and biomarkers of exposure to cig- Women: Diagnosis and Treat- The five-year grant is titled "Epigenetics arette smoke to determine those most at ment by APA Books and and Incubation of Craving" and runs risk for disease. This project was initially Dropping the Baby and Other Scary through May 2015. funded with American Recovery and Thoughts: Breaking the Cycle of Unwanted Reinvestment Act (ARRA) funds that Thoughts in Motherhood (with Karen Robert A. Schnoll, PhD published eight required re-application to continue years Kleiman) by Routledge. peer-reviewed papers in his field of nico- three and four with non-ARRA funding. tine addiction. Collectively, they: 1) evalu- George E. Woody, MD ated genetic variants and biomarkers Bruce I. Turetsky, MD and Chang-Gyu received funding from the related to responses to treatments for Hahn, MD, PhD are Co-Principal Investi- NIH for two research projects nicotine dependence; 2) identified predic- gators on a recent NIH R01 research grant being implemented abroad: tors of smoking behavior among cancer titled “Olfactory Evoked Potentials and “Adherence to HIV Therapy in Heroin patients who smoke and general popula- Developmental Neuropathology in Schiz- Addicts: Oral vs. Extended Release Nal- tion smokers undergoing treatment with ophrenia.” Also, Drs. Turetsky, Hahn, and trexone” in St. Petersburg, Russian Feder- nicotine replacement therapy; 3) delineat- Raquel E. Gur, MD, PhD are Co-PIs on a ation, and “Suboxone and Methadone for ed research priorities in the treatment of recent research grant from Pfizer titled HIV Risk Reduction in Subutex Injectors” nicotine dependence among cancer “Olfactory Probes of Negative Symptoms in Tbilisi, Republic of Georgia. He is a co- patients; and 4) identified barriers in in Schizophrenia: A Translational Study.” investigator in Reykjavik, Iceland on a physician practices hindering the integra- study of sustained-release, injectable nal- tion of pharmacogenetic approaches to Daniel Weintraub, MD led a study, pub- trexone for treating amphetamine the treatment of nicotine dependence. Dr. lished online in the journal Brain, which dependence and has helped train Ice- Schnoll also received an R21 grant from showed that a method of classifying brain landic staff on research procedures and the National Institute on Drug Abuse atrophy patterns in Alzheimer’s disease how to use this medication. Dr. Woody is (NIDA) titled “Efficacy of Varenicline for patients using MRIs can also detect cogni- also co-investigator on a study of medica- Smokeless Tobacco Use in India” tive decline in Parkinson’s disease. tion assisted therapies for opioid addic- (DA026404). The grant runs to 2012. Researchers also found that higher base- tion and HIV risk reduction strategies in line Alzheimer’s patterns of atrophy pre- Jakarta, Indonesia (Principal Investigator: Andrew A. Strasser, PhD is Principal dicted long-term cognitive decline in David S. Metzger, PhD) and has helped Investigator on several grants he received cognitively normal Parkinson’s patients. train Indonesian staff in these treatments. recently: 1) a one-year supplement grant Dr. Weintraub led another study, pub- In addition, Dr. Woody is PI on a U grant from the Food and Drug Administration lished in the December issue of the award which supports the Delaware Val- (FDA) and National Cancer Institute Archives of Neurology, which demonstrated ley Node of the National Institute on (NCI) to investigate eye tracking patterns that atrophy in the hippocampus, the Drug Abuse (NIDA) Clinical Trials Net- and risk beliefs in smokers viewing the region of the brain known for memory work. new graphic cigarette warning labels; 2) formation and storage, is evident in an NCI Administrative Supplement to an Parkinson’s disease patients with cogni-

MURALS AT HALL MERCER

Thanks to an extraordinarily generous and thoughtful donation by Dr. Lann Salyard and her husband, Chris Woehrle, a mural project was completed on the 2nd floor of Hall Mercer Community Behavioral Health Center at Pennsylvania Hospital. Nick Caprari, a local mural artist, transformed the 2nd floor patient waiting areas and created a warm and inspiring environment for clients, guests, and staff. The project is dedicated to the memory of Dr. Salyard’s late parents, Ann and Robert Salyard, whose family home provided the inspiration for the nature scenes throughout the mural. (Photos by Barry Ogburn)

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 26 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

RESEARCH GRANTS

The following sponsored research funding was received by the Department during the period May 1, 2010 through December 31, 2011

* Sponsored research funding during the period 9/1/09 through 4/30/10

New NIH Awards (includes New and Competing Renewals)

Name Sponsor Project Title ALTER, MARK NIH HOW THE LARGE-SCALE ORGANIZATION OF GENE EXPRESSION RELATES TO BEHAV- IOR IN MICE ALTERMAN, ARTHUR NIH / DARTMOUTH A STAGE II EFFICACY STUDY OF CBT FOR PTSD IN COMMUNITY ADDICTION TREAT- MENT

AMSTERDAM, JAY NIH RHODIOLA ROSEA THERAPY FOR MAJOR DEPRESSIVE DISORDER

ARNOLD, STEVEN NIH TARGETED PROTEOMICS OF RESILIENT COGNITION IN AGING

ARNOLD, STEVEN NIH ALZHEIMER'S DISEASE CORE CENTER

AUDRAIN-MCGOVERN, NIH SMOKING'S ROLE IN POSITIVE AFFECT AND REWARD REGULATION IN DEPRESSION- JANET PRONE SMOKERS

BARBER, JACQUES NIH / TREATMENT MONITORING AND FEEDBACK IN SUBSTANCE ABUSE TREATMENT* RESEARCH INSTI- TUTE

BECK, AARON NIH RESEARCH TRAINING FOR PREVENTION OF SUICIDE AND PSYCHOSIS: A PUBLIC HEALTH MODEL

BERRETTINI, WADE NIH MU OPIOID RECEPTOR GENE IN OPIOID ADDICTION

BERRETTINI, WADE NIH / UCSD PHARMACOGENOMICS OF MOOD STABILIZER RESPONSE IN BIPOLAR DISORDERS

BERTON, OLIVIER NIH ROLE OF HDAC6 IN A MURINE MODEL OF AFFECTIVE DISORDER AND ANTIDEPRES- SANT ACTION

BORGMANN-WINTER, NIH / CHOP NEUROPROTECTIVE/NEURODEVELOPMENTAL EFFECTS-ANTIPSYCHOTICS IN ADOLES- KARIN CENT PSYCHOSES

BROWN, GREGORY NIH COGNTIVE THERAPY FOR SUICIDAL OLDER MEN

BROWN, GREGORY NIH / CHOP ATTACHMENT-BASED FAMILY THERAPY FOR SUICIDAL ADOLESCENTS

CARLSON, GREGORY NIH FUNCTIONAL CIRCUIT DISORDERS OF SENSORY CORTEX IN ASD AND RTT

CAROFF, STANLEY NIH / COLUMBIA A COMPARISON OF LONG-ACTING INJECTABLE MEDICATIONS FOR SCHIZOPHRENIA (ACLAIMS)

CHHATRE, SUMEDHA NIH CANCER CARE AMONG MEDICARE HIV PATIENTS

CHILDRESS, ANNA NIH A T32 TRANSLATIONAL ADDITION RESEARCH FELLOWSHIP

CHILDRESS, ANNA NIH / DREXEL WEIGHT LOSS MAINTENANCE IN PRIMARY CARE*

COYNE, JAMES NIH / CHOP MULTICENTER METHODOLOGICAL STUDY TO ASSESS MENTAL DISORDERS FOR NCS BIRTH MOTHERS AND FATHERS

CRITS-CHRISTOPH, PAUL NIH THE MECHANISMS OF COGNITIVE AND DYNAMIC THERAPY IN COMMUNITY SETTINGS

EPPERSON, C. NEILL NIH DETERMINING THE NEUROENDOCRINE CONTRIBUTION TO BEHAVIOR & COGNITION ACROSS THE FEMALE LIFESPAN

FOA, EDNA NIH / MED UNIV INTEGRATED TREATMENT OF OEF/OIF VETERANS WITH PTSD AND SUBSTANCE USE SOUTH CAROLINA DISORDERS FRANKLIN, MARTIN NIH / JOHNS HOPKINS OCD COLLABORATIVE GENETICS ASSOCIATION STUDY

FRANKLIN, TERESA NIH CHARACTERIZING A CUE-VULNERABLE PHARMACO-RESPONSIVE ENDOPHENOTYPE IN SMOKERS Continued on page 27

www.med.upenn.edu/psych PAGE 27 www.med.upenn.edu/psych

Continued from page 26

New NIH Awards (Includes New and Competing Renewals) [continued]

Name Sponsor Project Title

GUR, RAQUEL NIH BRAIN-BEHAVIOR AND GENETIC STUDIES OF THE 22Q11DS

GUR, RUBEN NIH / HENRY M. JACKSON FOUN- MODIFIABLE RISK AND PROTECTIVE FACTORS FOR SUICIDAL BEHAV- DATION IORS IN THE US ARMY HADLEY, TREVOR NIH / TEMPLE RRTC ON PARTICIPATION AND COMMUNITY LIVING OF INDIVIDUALS WITH PSYCHIATRIC DISABILITIES HEMSLEY-FAULCON- NIH A NOVEL TREATMENT FOR OBESE DEPRESSED PATIENTS AT RISK FOR BRIDGE, LUCY CARDIOVASCULAR DISEASE HUGHES-HALBERT, NIH / DUKE DUKE CLINICAL AND TRANSLATIONAL SCIENCE AWARD (CTSA) CHANITA JEMMOTT, JOHN NIH "REALITY CHECK" IN TRANSIT: EVALUATION OF A SERIAL DRAMA FOR BLACK YOUTH KIM, DEBORAH NIH REPETITIVE TRANSCRANIAL MAGNET STIMULATION (rTMS) IN PREGNANT WOMEN WITH MDD KIM, SANGWON NIH MOLECULAR BASIS OF ATYPICAL ANTIPSYCHOTIC DRUGS-INDUCED WEIGHT GAIN KIM, SANGWON NIH / CHOP THYROID HORMONE INDUCIBLE SMALL GTPPASE, RHES-MEDIATED IRON TRAFFICKING AND NEURONAL FUNCTION KRAL, TANJA NIH INDIVIDUAL DIFFERENCES IN CHILDREN'S SUSCEPTIBILITY TO OVEREAT- ING KRANZLER, HENRY NIH NOVEL APPROACHES TO ALCOHOLISM PHARMACOTHERAPY AND RISK

KRANZLER, HENRY NIH / UNIV CONNECTICUT HEALTH CENTER FOR RESEARCH ON THE ETIOLOGY AND TREATMENT OF ALCO- CENTER HOL DEPENDENCE KRANZLER, HENRY NIH / UNIV NORTH CAROLINA DEEP SEQUENCING STUDIES FOR CANNABIS AND STIMULANT DEPEND- ENCE KRANZLER, HENRY NIH / YALE GENETICS OF ALCOHOL DEPENDENCE IN AMERICAN POPULATION

KRANZLER, HENRY NIH / YALE GENETICS OF ALCOHOL IN AFRICAN AMERICANS

KRANZLER, HENRY NIH / YALE GENETICS OF COCAINE DEPENDENCE: SEMI-STRUCTURED ASSESSMENT FOR DRUG DEPENDENCE AND ALCOHOLISM (SSADDA) LEITMAN, DAVID NIH MULITMODEL NEUROIMAGING OF PROSODY IN SCHIZOPHRENIA AND DEVELOPMENTAL DISORDERS LERMAN, CARYN NIH PHARMACOGENETICS OF NICOTINE ADDICTION AND TREATMENT

LERMAN, CARYN NIH COGNITIVE TRAINING FOR NICOTINE DEPENDENCE

LUCKI, IRWIN NIH REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTS

LUCKI, IRWIN NIH TRAINING PROGRAM IN NEUROPSYCHOPHARMACOLOGY

MCKAY, JAMES NIH ADAPTIVE TREATMENT MODELS FOR THE MANAGEMENT OF DRUG USE DISORDERS METZGER, DAVID NIH / WISTAR INSTITUTE OF NK CELL ACTIVATION AND FUNCTION IN HIV-1 EXPOSED UNINFECTED IV ANATOMY AND BIOLOGY DRUG USERS*

MOBERG, PAUL NIH / THOMAS JEFFERSON UNI- PREVENTING COGNITIVE DECLINE IN AFRICAN AMERICANS WITH MILD VERSITY COGNITIVE IMPAIRMENT

PIERCE, R. CHRISTO- NIH PSYCHOSTIMULANT-INDUCED CRAVING AND TOXICITY PHER

RAO, HENGYI NIH NEURAL BASIS FOR DIFFERENTIAL VULNERABILITY TO SLEEP DEPRIVA- TION ROSS, RICHARD NIH / VETERANS MEDICAL TREATING INSOMNIA AND NIGHTMARES AFTER TRAUMA: IMPACT ON RESEARCH FOUNDATION SYMPTOMS & QUALITY OF LIFE Continued on page 28

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 28 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 27

New NIH Awards (Includes New and Competing Renewals) [continued]

Name Sponsor Project Title

SCHMIDT, HEATH NIH EPIGENETICS AND INCUBATION OF CRAVING STRASSER, ANDREW NIH / BATTELLE MEMORIAL INSTI- ROLL YOUR OWN (RYO) CIGARETTES: PREVALENCE, SMOKING BEHAV- TUTE IOR AND TOXIN EXPOSURE* SUH, JESSE NIH BRAIN SUBSTRATES OF AFFECT DYSREGULATION IN COCAINE ADDIC- TION: A PILOT STUDY TEEGARDEN, SARAH NIH THE ROLE OF HDA6 AND GLUCOCORTICOID SIGNALING IN RESILIENCE TO DEPRESSION THASE, MICHAEL NIH EFFICACY OF COMPUTER-ASSISTED COGNITIVE BEHAVIOR THERAPY FOR DEPRESSION THASE, MICHAEL NIH / UNIV PITTSBURGH PSYCHOTHERAPY FOR THE ACUTE TREATMENT OF BIPOLAR II DEPRES- SION* TURETSKY, BRUCE NIH OLFACTORY EVOKED POTENTIALS AND DEVELOPMENTAL NEU- ROPATHOLOGY IN SCHIZOPHRENIA WADDEN, THOMAS NIH / WAKE FOREST UNIVERSITY ACTION FOR HEALTH IN DIABETES BRAIN MAGNETIC RESONANCE IMAG- ING ANCILLARY STUDY WOODY, GEORGE NIH DELAWARE VALLEY NODE OF THE CLINICAL TRIALS NETWORK

Other Federal Agencies

Name Sponsor Project Title BASNER, MATHIAS FEDERAL AVIATION ADMINISTRA- PARTNER COE PROJECT 25B: EFFECTS OF AIRCRAFT NOISE ON SLEEP TION

BASNER, MATHIAS NATIONAL SPACE BIOMEDICAL INDIVIDUALIZED REAL-TIME NEUROCOGNITIVE ASSESSMENT TOOLKIT RESEARCH INSTITUTE FOR SPACE FLIGHT FATIGUE

BROWN, GREGORY DEPARTMENT OF DEFENSE / A BRIEF INTERVENTION TO REDUCE SUICIDE RISK IN MILITARY SERVICE HENRY M. JACKSON FOUNDATION MEMBERS AND VETERANS

DINGES, DAVID DEPARTMENT OF THE NAVY SYSTEM FOR ASSESSMENT OF NEUROBEHAVIORAL CAPABILITY IN NAVAL OPERATIONS

FOA, EDNA DEPARTMENT OF JUSTICE / UNIV BREAKING THE CYCLE OF BEHAVIORAL HEALTH PROBLEMS AND CRIME CONNECTICUT HEALTH CENTER IV: PTSD TREATMENT WITH MALE MILITARY VETERANS REPORTING PROBLEMS WITH AGGRESSION AFTER RETURN FROM WARZONE DEPLOYMENT FOA, EDNA VA-VAMC CHARLESTON PE-WEB: ONLINE TRAINING FOR VA PROVIDERS IN PROLONGED EXPO- SURE FOR PTSD

GOEL, NAMNI DEPARTMENT OF THE NAVY PHENOTYPIC AND GENOTYPIC MARKERS OF PERFORMANCE VULNERA- BILITY TO SLEEP LOSS

HUEGE, STEVEN HEALTH RESOURCES & SERVICE GERIATRIC PSYCHIATRY AND INTERDISCIPLINARY EDUCATION ADMINISTRATION (HRSA)

HUGHES-HALBERT, AGENCY FOR HEALTHCARE DISSEMINATING BREAST CANCER PREVENTION TO AFRICAN AMERICAN CHANITA RESEARCH AND QUALITY (AHRQ) WOMEN

MANDELL, DAVID HEALTH RESOURCES & SERVICE AUTISM INTERVENTION RESEARCH NETWORK FOR BEHAVIORAL HEALTH ADMINISTRATION / UNIVERSITY OF CALIFORNIA, LOS ANGELES THASE, MICHAEL AGENCY FOR HEALTHCARE COMPARATIVE EFFECTIVENESS STUDY FOR BIPOLAR DISORDER RESEARCH AND QUALITY / MAS- SACHUSETTS GENERAL HOSPITAL Other Agencies and Organizations Name Sponsor Project Title ALLISON, KELLY THE OBESITY SOCIETY PREVENTING EXCESS WEIGHT GAIN DURING PREGNANCY USING INTE- GRATED TECHNOLOGIES

ALTER, MARK SIMONS FOUNDATION TRANSCRIPTIONAL RESPONSIVENESS IN LYMPHOBLASTOID CELL LINES

Continued on page 29

www.med.upenn.edu/psych PAGE 29 www.med.upenn.edu/psych

Continued from page 28

Other Agencies and Organizations (continued) Name Sponsor Project Title BASNER, MATHIAS EUROPEAN COMMISSION ENNAH - EUROPEAN NETWORK ON NOISE AND HEALTH

BECK, AARON THE VAN AMERIGEN FOUNDA- INTENSIVE COGNITIVE THERAPY TRAINING FOR CASE MANAGERS IN TION, INC. SAFE HAVENS

BERRETTINI, WADE DAVIS (HILDA & PRESTON) FOUN- GENETICS OF ANOREXIA NERVOSA DATION

BERTON, OLIVIER INTERNATIONAL MENTAL HEALTH HDAC6, A NEW THERAPEUTIC TARGET FOR ANTIDEPRESSANT AND RESEARCH FOUNDATION PRO-RESILIENCE INTERVENTIONS

CHILDRESS, ANNA COMMONWEALTH OF PA A CURE ADDICTION CENTER OF EXCELLENCE: BRAIN MECHANISMS OF RELAPSE AND RECOVERY

FRANKLIN, TERESA DANA FOUNDATION USE OF SPECT AND PERFUSION fMRI TO EXAMINE THE ROLE OF DAT GENOTYPE IN MOTIVATED SMOKING BEHAVIOR

HAHN, CHANG-GYU NATIONAL ALLIANCE FOR NMDA RECEPTOR COMPLEXES IN SCHIZOPHRENIA RESEARCH ON SCHIZOPHRENIA AND DEPRESSION

HAYES, MATTHEW NATIONAL DAIRY COUNCIL DAIRY MACRONUTRIENTS ENHANCE GLUCAGON-LIKE-PEPTIDE-1 RECEPTOR MEDIATED SUPPRESSION OF FOOD INTAKE AND BLOOD GLUCOSE REGULATION

HUGHES-HALBERT, AMERICAN CANCER SOCIETY / BEHAVIORAL AND EMOTIONAL IMPACT OF BRCA TESTING IN AFRICAN CHANITA MOFFITT CANCER CENTER AMERICANS (BENITA)

KAMATH, VIDYULATA AMERICAN PSYCHOLOGICAL NEUROPSYCHOLOGICAL PROBES OF ORBITOFRONTAL DYSFUNCTION ASSOCIATION

KIM, SANGWON THE PHILADELPHIA FOUNDATION / THYROID HORMONE INDUCIBLE SMALL GTPase, RHES-MEDIATED IRON CHOP TRAFFICKING AND NEURON

KIM, SANGWON AMERICAN FEDERATION FOR THE ROLE OF PHOSPHOINOSITIDES IN CELLULAR GROWTH AND AGING AGING RESEARCH

KIM, SANGWON NARSAD VALIDATION OF A THERAPEUTIC TARGET TO INTERVENE AAPDs-MEDI- ATED OBESITY IN A CELL MODEL

LOCKE, JILL AUTISM SCIENCE FOUNDATION CLASSROOM AIDE MEDIATED PEER INSTRUCTION

LOHOFF, FALK AMERICAN FOUNDATION FOR SUI- GLOBAL EXPRESSION ANALYSIS OF PATIENTS WITH TREATMENT EMER- CIDE PREVENTION GENT SUICIDAL IDEATIONS

MANDELL, DAVID AUTISM SPEAKS AUTISM ECONOMICS - LITERATURE REVIEW

MCKAY, JAMES PHILADELPHIA MENTAL HEALTH EFFECTIVENESS OF EXTENDED TREATMENT OF DRUG DEPENDENCE, CARE CORPORATION CITY SUPPLEMENT

METZGER, DAVID INTERNATIONAL AIDS VACCINE IAS-NIDA MENTORING FELLOWSHIP INITIATIVE

OLSIN, DAVID FOX CHASE CANCER CENTER BIOPSYCHOSOCIAL RELATIONSHIPS UNDERLYING INDOOR TANNING EXPERIENCE

SARWER, DAVID ETHICON ENDO-SURGERY, INC. RELATIONSHIP OF REALIZE MY SUCCESS USAGE TO OUTCOMES OF BARIATRIC SURGERY

SATTERTHWAITE, AMERICAN PSYCHOLOGICAL LILLY PSYCHIATRIC RESEARCH FELLOWSHIP THEODORE ASSOCIATION

SATTERTHWAITE, NARSAD NEUROIMAGING OF REWARD IN BIPOLAR DEPRESSION THEODORE

SIEGEL, STEVEN ASTELLAS PHARMA, INC. PHARMACOLOGIC REVERSAL OF ELECTRO- PHYSIOLOGICAL DEFICITS IN NR1 HETEROZYGOUS MICE Continued on page 30

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 30 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 29 Clinical Trials Name Sponsor Project Title ARNOLD, STEVEN UNIVERSITY OF CALIFORNIA, SAN AMYLOID IMAGING, VMCI, AND ANALYSIS FOR ADNI DIEGO ARNOLD, STEVEN PFIZER, INC. A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO- CONTROLLED, PARALLEL GROUP, EFFICACY AND SAFETY TRIAL OF BAP- INEUZUMAB (AAB-001, ELN 115727) IN SUBJECTS WITH MILD TO MODERATE ALZHEIMER'S DISEASE WHO ARE APOLIPOPROTEIN E 4 CAR- RIERS ARNOLD, STEVEN ELI LILLY AND COMPANY OPEN-LABEL EXTENSION FOR ALZHEIMER'S DISEASE PATIENTS WHO COMPLETE ONE OF TWO SEMAGACESTAT PHASE 3 DOUBLE-BLIND STUDIES (H6L-MC-LFAN OR H6L-MC-LFBC) ARNOLD, STEVEN JANSSEN ALZHEIMER A PHASE 3 EXTENSION, MULTICENTER, DOUBLE-BLIND, LONG TERM IMMUNOTHERAPY RESEARCH AND SAFETY AND TOLERABILITY TREATMENT TRIAL OF BAPINEUZUMAB, (AAB DEVELOPMENT, LLC 001, ELN115727-351) IN SUBJECTS WITH ALZHEIMER'S DISEASE WHO PARTICIPATED IN STUDY ELN115727-301 OR IN STUDY ELN115727-302

ARNOLD, STEVEN PFIZER, INC. A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO- CONTROLLED, PARALLEL-GROUP, EFFICACY AND SAFETY TRIAL OF BAP- INEUZUMAB (AAB-001, ELN115727) IN SUBJECTS WITH MILD TO MODERATE ALZHEIMER DISEASE WHO ARE APOLIPOPROTEIN E 4 NON- CARRIERS

ARNOLD, STEVEN NEURONETRIX, INC. EVALUATION OF A HAND HELD EVENT RELATED POTENTIAL (ERP) SYS- TEM (COGNISIONTM) AS A USEFUL BIOMARKER FOR ALZHEIMER'S DIS- EASE BHATI, MAHENDRA AMERICAN PSYCHIATRIC ASSOCI- DSM-5 FIELD TRIAL PROPOSAL AITON DINGES, DAVID MERCK & CO., INC PENN COGNITIVE TEST BATTERY ON MK-7288 PN010: CAR DRIVING STUDY IN OSA PATIENTS EPPERSON, C. NEILL SHIRE PHARMACEUTICAL DEVEL- ATTENTION & MEMORY IMPAIRMENTS IN MENOPAUSAL WOMEN: A POS- OPMENT, INC. SIBLE ROLE FOR VYVANSE? KAMPMAN, KYLE TITAN PHARMACEUTICALS PRO-806: A RANDOMIZED, PLACEBO AND ACTIVE-CONTROLLED, MULTI- CENTER STUDY OF PROBUPHINE IN PATIENTS WITH OPIOID DEPEND- ENCE KAMPMAN, KYLE TITAN PHARMACEUTICALS A PHASE 3, SIX MONTHS, OPEN-LABEL RE-TREATMENT STUDY OF PROBUPHINE IN OPIOID ADDICTION LERMAN, CARYN PFIZER, INC PHARMACOGENETICS OF NICOTINE ADDICTION TREATMENT (PNAT) LERMAN, CARYN PFIZER, INC GRAND 2010: NICOTINIC RECEPTOR AVAILABILITY IN SLOW AND FAST NICOTINE METABOLIZERS PETTINATI, HELEN FAST-TRACK DRUGS & BIOLOGICS, A PHASE 2, DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL TO ASSESS LLC. THE EFFICACY OF VARENICLINE TARTRATE FOR ALCOHOL DEPENDENCE IN VERY HEAVY DRINKERS SCHNOLL, ROBERT PFIZER, INC. EFFICACY OF VARENICLINE FOR SMOKELESS TOBACCO USE IN INDIA* THASE, MICHAEL ELI LILLY AND COMPANY A STUDY TO ASSESS THE LONG-TERM EFFICACY AND THE SAFETY OF OLANZAPINE AND FLUOXETINE COMBINATION VERSUS FLUOXETINE ONLY IN THE RELAPSE PREVENTION OF STABILIZED PATIENTS WITH TREATMENT-RESISTANT DEPRESSION* THASE, MICHAEL OTSUKA PHARMACEUTICAL DEVEL- A PHASE 2, MULTICENTER OPEN LABEL STUDY TO ASSESS THE SAFETY OPMENT AND COMMERCIALIZA- AND TOLERABILITY OF ORAL OPC-34712 AS ADJUNCTIVE THERAPY IN TION, INC. ADULT PATIENTS WITH MAJOR DEPRESSIVE DISORDER*

THASE, MICHAEL OTSUKA PHARMACEUTICAL DEVEL- A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, OPMENT AND COMMERCIALIZA- DOSE-RANGING STUDY OF THE SAFETY AND EFFICACY OF OPC-34712 TION, INC. AS ADJUNCTIVE THERAPY IN THE TREATMENT OF ADULTS WITH MAJOR DEPRESSIVE DISORDER THASE, MICHAEL NEOSYNC, INC. EVALUATION OF LOW EMISSION NEOSYNC EEG SYNCHRONIZED TMS TECHNOLOGY FOR THE TREATMENT OF MAJOR DEPRESSIVE DISORDER: A MULTICENTER RANDOMIZED, DOUBLE-BLIND, SHAM-CONTROLLED, TRIAL WADDEN, THOMAS NUTRISYSTEM, INC. A COMPARISON OF GLYCEMIC STABILITY & VARIABILITY DURING CON- SUMPTION OF USUAL DIET OR NUTRISYSTEM-D AMONG PATIENTS WITH TYPE 2 DIABETES

www.med.upenn.edu/psych PAGE 31 www.med.upenn.edu/psych

OUR DEPARTMENT ININ THE NEWS

[* indicates news story is available on the Web by accessing the "Penn Psychiatry in the News" section of the departmental website – www.med.upenn.edu/psych/news.html]

Kelly Allison, PhD was interviewed by Penn Gazette about the efforts of these review of new diet drugs. Later in the WHYY Radio (Philadelphia) on Decem- investigators to attack Alzheimer’s and year, he told CBS3 (Philadelphia) that a ber 3, 2010 for a story* about holiday other neurodegenerative diseases. Dr. new drug, just recommended by an FDA goodies in the office. In an April 21, 2011 Arnold was interviewed in an April 15 advisory committee panel for approval, is Windsor Star article, she discussed night Philadelphia Inquirer report* about the a combination of two drugs already on eating syndrome – a phenomenon where FDA's review of the association between the market – Wellbutrin, an antidepres- people consume at least one-quarter of the statin class of cholesterol-lowering sant, and Naltrexone, an anti-addiction their daily calories after the evening medicines and memory loss. medication. Dr. Berkowitz spoke with meal. Albert J. Stunkard, MD first CBS3 (Philadelphia) for a January 13, described night eating syndrome in 1955 An article* in the September 12, 2011 2011 story* about new U.S. Department as a peculiar pattern of food intake Philadelphia Inquirer reported on an epige- of Agriculture guidelines for school among certain obese patients. In the July netics study led by Tracy L. Bale, PhD, lunches. He was mentioned in a Novem- 11, 2011 issue of Women’s World maga- which showed that maternal stress dur- ber 2 CBS News article* discussing new zine, she contributed a response about ing pregnancy may have negative conse- research which suggests that exercise can night eating syndrome in a Q & A fea- quences on not only the fetus but also the help keep those with the ‘obesity gene’ ture. fetus' children. The finding was pub- from gaining weight. He was quoted in a lished in the Journal of Neuroscience. An November 2 USA Today story* about a Steven E. Arnold, MD interview with Dr. Bale about this line of new study suggesting that individuals was quoted in a May 19, research was published by the journal genetically predisposed to obesity can 2010 Medscape Neurolo- BioTechniques in December 2011. reduce their odds of gaining weight by gy story* about a new staying physically active. Penn Medicine study Christos Ballas, MD spoke* with AOL suggesting that genetics Health on June 3, 2010 about a recent Steven J. Berkowitz, may not only impact the study done by British scientists claiming MD commented in an risk for dementia but also the nature of that coffee drinkers don't get any true MSNBC.com article* on the dementia syndrome. He was also wake-me-up perks from their morning a recent study, which interviewed in a July 6, 2010 WHYY brew. investigated a medica- (Philadelphia) Radio story* regarding Mathias Basner, MD, PhD, MSc was tion that can prevent an two new studies published in the journal quoted in an August 10, 2010 Science exaggerated fear Neurology which support the theory that News article*, which reported on a new response in mice very depression and dementia are linked. Dr. study showing that sound sleepers pro- similar to post-traumatic stress disorder Arnold was quoted in a July 13, 2010 duce distinctive brain signals enabling (PTSD) in people. He was interviewed by MSNBC.com report* on research which them to sustain sleep in noisy environ- 6ABC (Philadelphia) in a March 14, 2011 found that a large cranium indicates a big ments. He was quoted in a March 7, 2011 story* about the psychological impact of brain and that having a bigger brain Wired Magazine article* about brain activi- the devastation in Japan. He was inter- might help preserve thinking and memo- ty during sleep. Dr. Basner was quoted in viewed by the Philadelphia Inquirer* (May ry. He was also interviewed in a July 26, a May 13 article in The Globe and Mail 3) and MSNBC.com* (May 3) regarding 2010 Los Angeles Times article*, looking at titled "Sleep Deprivation is a National psychological reactions to Bin Laden's a group known as the Graduation Club, Epidemic, And It's Killing Us.” Both death. Dr. Berkowitz was a featured an Alzheimer's Association support David Dinges, PhD and Dr. Basner are expert on a June 27 WHYY (Philadel- group that encourages members to dis- mentioned in this article. Dr. Basner par- phia)/NPR Radio segment* discussing cuss their hopes, fears and frustrations, ticipated in a May 24 radio interview the effects of violence on children. He many of which come from knowing the with radio station rbb (Berlin, Germany) explained in a July 19 Philadelphia Inquirer road that lies ahead. Dr. Arnold is lead- on the effects of aircraft noise on sleep article* that the instinct to help, even in ing a Penn Memory Center resilience and health. the face of danger, could be a genetic pre- study looking at the impact of stress on disposition. Dr. Berkowitz was inter- aging brain function, which was reported Aaron T. Beck, MD, the “father of cogni- viewed in an August 2 MSNBC.com on by the Bucks County Courier Times and tive therapy,” turned 90 in the summer of article* about a new study which showed MSNBC.com in January 2011. He also 2011 and was featured in a July 15, 2011 that a medication (risperidone) common- commented in a January 20 WHYY Radio Psychiatric News article* which looked at ly used to treat PTSD in combat veterans (Philadelphia) report* about the use of a the man and his career. He was also spot- may not be effective in reducing overall new nuclear medicine imaging test to lighted in an August 8 column* by Art PTSD severity. The research of Dr. determine if a patient has Alzheimer's Carey in the Philadelphia Inquirer. Berkowitz and Edna B. Foa, PhD was disease. Dr. Arnold and more than a cited in a September 5 WHYY Radio Robert I. Berkowitz, MD was inter- dozen other Penn scientists were high- (Philadelphia)/NPR report* documenting viewed for a July 12, 2010 segment* on lighted in a cover story and series of arti- the progress made toward understanding ABC World News Tonight with Diane cles* in the March/April issue of the PTSD after 9/11. Dr. Berkowitz spoke Sawyer, discussing the upcoming FDA Continued on page 32

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 32 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 31

with the Philadelphia Inquirer for a Decem- tive attitude in battling cancer. The ber 13 story* about the impact court pro- results of his and other studies were that In continuing coverage in July ceedings may have on abuse victims. there is little relationship between atti- and August 2010, more than 65 tude and clinical outcome. "It's disturb- TV and radio stations across the coun- Wade H. Berrettini, MD, PhD was men- ing at some level that attitude doesn't try (including 6ABC in Philadelphia, tioned in a March 9, 2011 Philadelphia matter for survival," said Dr. Coyne. WCBS in New York, and KABC in Los Angeles) and various other media out- Inquirer article*, which noted his talk at "There are some things you can modify lets (including the Los Angeles Times*, the Philadelphia Science Festival about in life, but cancer is not one of them." genetic variants that can contribute to CNN.com*, and Cosmopolitan*) high- addiction. He was one of a team of inves- Guy S. Diamond, PhD was quoted in a lighted a new study by David F. tigators in a study which provided addi- June 29, 2010 Wall Street Journal article* Dinges, PhD and colleagues, which tional support for the genetic basis of looking at what happens when typical found that a 10-hour "recovery" snooze eating disorders. The research, published teen angst starts to look like something was not sufficient to make up for a few in Neuropsychopharmacology, was reported much darker and more troubling. nights of four hours of sleep. "Lifestyles in a July 27 article* found on examin- that involve chronic sleep restriction dur- er.com. Joseph DiGiacomo MD participated in a ing the work week and during days off panel discussion titled “Antipsychotics – work may result in continuing build-up of Mahendra T. Bhati, MD appeared in a Where Doctors, Lawyers and Big Pharma sleep pressure and in an increased like- February 22, 2011 6ABC (Philadelphia) Meet, The Intersection of Antipsychotics, lihood of loss of alertness and increased special report* looking at object and ani- Psychiatry & the Law” sponsored by The errors," Dr. Dinges said. "The bottom mal hoarding. He was interviewed in a American Law Journal and telecast by line is that adequate recovery sleep July 27 NBC10 (Philadelphia) report* CNN News affiliate WFMZ-TV (Allen- duration is important for coping with the about animal hoarding. In an August 4 town, Pennsylvania) on May 10, 2010. effects of chronic sleep restriction on story* in the Huffington Post, Dr. Bhati the brain." commented on antidepressant use among An article* in the June 3, 2010 Philadelphia undiagnosed Americans. Inquirer noted that David F. Dinges, PhD will be monitoring the mental health of tion on the brain. His work was featured Edward S. Brodkin, MD six Russian scientists who are attempting in an April 17 New York Times Magazine was interviewed by the to remain cooped up in a fake spaceship article* about the effects of sleep depriva- Autism Science Founda- for 520 days – about the length of time it tion. The April 25 Daily Pennsylvanian tion on October 17, 2011 would take to get to Mars and back.A reported on Dr. Dinges’ research findings about his research using February 9, 2011 Daily Pennsylvanian arti- recommending nine hours of sleep each mouse models to study cle* also reported on the efforts of Dr. night for the average healthy person. Dr. the sociability of children Dinges and Mathias Basner, MD, PhD, Dinges was interviewed for a July 1 story with autism MSc to "understand the effects of long- in the Philadelphia Inquirer about new reg- [http://www.youtube.com/watch?v=sS_ duration space travel" on human behav- ulations requiring shorter hours for resi- AzbWmT6g]. ior through testing done during the dent physicians in hospitals. He spoke to simulated Mars mission. In a July 1, 2010 a New York Times travel writer for a Sep- James C. Coyne, PhD and Aaron T. ABCNews.com article* about taking tember 27 story* about sleeping on long Beck, MD were quoted in a May 30, 2010 lunch breaks at work, Dr. Dinges flights, and discussed the ability to Philadelphia Inquirer article* discussing described the important roles eating and change one's circadian clock in a Novem- positive psychology. Dr. Coyne was sleeping have on brain efficiency. He was ber 20 New York Times article* about quoted in an August 13, 2010 Reuters interviewed* for a July 26, 2010 WNYC becoming a morning person. Dr. Dinges’ article* reporting a new study which (New York) Radio Show, The Takeaway, research was discussed in a December 13 found that personality does not seem to about sleep problems and the latest sleep Scienceline.com article* about drowsiness be connected to the risk of developing or research. In an August 25, 2010 Associat- detection technologies in cars. dying from cancer – he also co-authored ed Press article* in the Philadelphia Inquir- an editorial published with the study. Dr. er, Dr. Dinges was interviewed regarding C. Neill Epperson, MD and Steven J. Coyne was quoted in a June 13, 2011 Los his research on astronauts and their Berkowitz, MD were featured in a May Angeles Times article* about the role a response to isolation and stress, compar- 19, 2010 parenting segment* on 6ABC patient's outlook plays during cancer ing their experience to that of 33 trapped (Philadelphia) about childhood develop- treatment. He was quoted in an August miners in Chile. "Hope is a resource in ment comparisons. Dr. Epperson was 15 Philadelphia Inquirer article* discussing this environment," Dr. Dinges said, espe- quoted in a July 30, 2010 MSNBC.com the concept of "the positive side of trau- cially if the miners are trying to help their article* that looked at a woman from ma and grief.” Dr. Coyne authored two own rescue. "If they can be an agent of Villers-au-Tertre, France, who admitted articles* in Psychology Today (September 2 their own rescue, that helps enormously." to suffocating her newborns, and whether and 6) examining evidence claiming that He was also interviewed in a December or not these murders were a result of “virtual trauma” from watching media 7, 2010 Medscape report* regarding the psychological issues. She was also inter- coverage of 9/11 could elicit posttrau- cognitive deficits caused by sleep depri- viewed by the Delaware News Journal for a matic stress reactions and persist in the vation. Dr. Dinges was interviewed in a February 8, 2011 article* looking at the absence of a direct exposure to events. February 28, 2011 Philadelphia Inquirer impact that losing a best friend, soul On November 27, 2011, he was inter- article* looking at fatigue and ways to mate, or lifelong companion has on a per- viewed for a CBS Sunday Morning News detect sleepiness and in a WebMD.com son's health. Dr. Epperson was quoted in story concerning effects of having a posi- article* about the effect of sleep depriva- a Reuters Health article* which reported ContinuedContinued on page on page 33

www.med.upenn.edu/psych PAGE 33 www.med.upenn.edu/psych

Continued from page 32

that an ADHD medication may improve treatment. Dr. Foa was quoted in an and he discussed various studies investi- subjective attention and reduce memory April 4 Austin-American Statesman article* gating insomnia. The studies are looking difficulties in perimenopausal and post- about a new eye track test for PTSD. at behavioral issues, possible medication- menopausal women. She led a study pro- KYW (Philadelphia) Radio* spoke with based treatments, and cancer survivors' viding the first potential treatment for Dr. Foa on June 3 about PE Therapy as a sleep patterns. He spoke with Philadelphia menopause-related cognition deficits – treatment for veterans suffering from Magazine for a January 2011 Q & A entry* the research was featured on NBC10 PTSD. The research of Dr. Foa and about Seasonal Affective Disorder reme- (Philadelphia). Dr. Epperson discussed Steven J. Berkowitz, MD was cited in a dies. He was interviewed by ABC- the value of day care as a means of curb- September 5 WHYY Radio (Philadel- News.com for a March 11 story* about ing behavioral issues in a June 13 phia)/NPR report* about the progress the effects of daylight saving time on MSNBC.com report*. She was inter- made toward understanding PTSD after sleep, and discussed children's sleep viewed for a November 29 WHYY News- 9/11. problems with ABCnews.com in an April works article* in which she talked about 1 story*. On April 12, Dr. Gehrman joined depression treatment during pregnancy. Martin E. Franklin, PhD was inter- the weekly ABC News Medical Unit viewed in a May 25, 2011 ABCNews.com online Twitter health chat to talk about In a June 13, 2010 Philadelphia Inquirer report* about trichotillomania, a psycho- sleep. He appeared on April 15 on ABC's story*, James C. Findley, PhD, D,ABSM, logical disorder that causes people to pull Good Morning America and World News CBSM of the Behavioral Sleep Medicine out hair from their head and other parts Tonight segments about issues surround- Program discussed insomnia and sleep of the body to the extent that it causes ing sleepy air traffic controllers. Dr. habits. Dr. Findley and Philip R. patches of baldness. He led a study, Gehrman discussed circadian rhythm in Gerhman, PhD, CBSM were quoted in a reported in the Journal of the American an April 19 Palm Beach Post article* about July 16, 2010 Philadelphia Inquirer article* Medical Association, which found that the FAA's campaign to prevent air traffic about the negative impact that non-sleep adding cognitive-behavior therapy to controllers from falling asleep on the job. activities in the bedroom may have on a maintenance treatment with SSRIs can He spoke with Oprah.com for an October person's ability to fall asleep. significantly improve symptoms of 12 story* about ways to synchronize our Obsessive-Compulsive Disorder (OCD) Edna B. Foa, PhD was featured on MSN's body clock to the earth's 24-hour cycle, in children and adolescents. Reuters using external cues – such as artificial list of the "smartest people in the world." Health (September 20)*, MedPage Today The MSN article* noted that, for 30 years, light – to help combat against the biologi- (September 20)*, HealthDay, and Med- cal factors that make us feel tired and Dr. Foa has studied one of the most scape covered the story. debilitating psychological diseases in sluggish in the morning. modern history – post-traumatic stress A new study published in Namni Goel, PhD was quoted in a July disorder (PTSD). Ten years ago, she the January 3, 2011 online 2010 article* in SELF magazine that fea- began developing a cognitive approach issue of Archives of General tured eight simple tricks a person can do to curing it – Prolonged Exposure Thera- Psychiatry, led by Teresa R. to improve one's mood, memory, and py (PE) – that is just now being embraced Franklin, PhD, found that other health issues. She also led a study, by the mainstream. Dr. Foa discussed PE varenicline (Chantix®), a published in Neurology in October 2010, with FOX29 (Philadelphia) in a Novem- drug that helps people stop that found that a genetic marker associat- ber 2010 story* regarding her work with smoking, may change the way the brain ed with narcolepsy may determine America's war veterans living with PTSD. reacts to smoking cues, such as seeing sleepiness. The story was covered by In a November 30, 2010 story* reported someone else smoke. Stories in Health- HealthDay News*, CNN.com*, and by the U.S. Army, Dr. Foa presented on Day News* (January 3), nbc4i.com (Janu- WebMD* on October 25; ABCNews.com* PE at the 27th Army Science Conference, ary 4), MedPage Today* (January 5), and and a CBS News interview on October discussing its effectiveness in treating Medscape Medical News (January 12) 26; the CBS Early Show* on October 28; PTSD and whether PE can be effective in reported this finding, the first demon- the Seattle Times* on December 2, as well treating PTSD among active personnel. strated identification of the mechanism as by the Daily Mail (UK), Los Angeles Dr. Foa was also interviewed in a Sep- underlying a medication’s effectiveness Times, AOL Health, NBC affiliates, and tember 2010 Glamour magazine article* to reduce cue reactivity in smoking. other outlets around the country. Dr. about anxiety in women, and she was Rollin M. Gallagher, MD Goel was interviewed by the Daily Bruin featured in a Summer 2010 article* for an April 13, 2011 story discussing appearing in Proto, a Massachusetts Gen- was quoted in a May 13, 2010 HealthDay News article*, individual differences in response to eral Hospital magazine, discussing post- sleep loss. traumatic stress disorder. She was describing the complicated interviewed by ABCNews.com on Octo- problems, including cognitive Marina Goldman, MD was quoted in a ber 13, 2010 about the mental health of and emotional issues and acute and June 25, 2010 Philadelphia Magazine arti- the Chilean miners following their res- chronic pain, that have long-lasting cle*, regarding the potential side effects cue. She was profiled in a January 2, 2011 implications for veterans and make treat- of marijuana use. front-page story* in the Sunday Philadel- ment outcomes difficult to achieve. He phia Inquirer. In a February 15 O Magazine was also quoted in a March 11, 2011 Time The LA Times reported in a May 17, 2011 article* – “Can a Single Pill Change Your Magazine article on the challenges and article* on a new study led by Psychiatry Life?”– Dr. Foa and Elna Yadin, PhD consequences of living with chronic pain. resident Laurie B. Gray, MD, which were asked to comment on the role of showed that most children who lose a Philip Gehrman, PhD, CBSM was inter- parent don't experience a lengthy clinical MDMA (the active ingredient in the viewed on CBS3's Talk Philly program, street drug Ecstasy) as a potential PTSD depression. Continued on page 34

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 34 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 33 Ruben C. Gur, PhD was quoted in a the brain. appeared in HealthDay and Medscape. December 16, 2010 ABCNews.com Research led by Dr. Mandell was dis- report* about a study published in the Mary Anne Layden, PhD was inter- cussed in a December 16, 2011 Los Ange- latest edition of Current Biology that viewed for a July 5, 2010 LifeSite- les Times article*, the last in a four-part looked at how a certain part of the brain, News.com article*, which examined series, looking at adults with undiag- the amygdala, experiences fear. ways to make pornography socially nosed autism. unacceptable, much like the process suc- Steven F. Huege, MD was featured in an cessfully applied to tobacco use. She also Stephen J. Morse, JD, August 16, 2011 article on dementia spoke with the Philadelphia Inquirer for a PhD spoke on a July 6, symptoms and diagnosis for Milestones January 28, 2011 article* about protecting 2010 “Talk of Nation” newspaper, published by the Philadel- women from the damages and ravages NPR broadcast on neu- phia Corporation for Aging. of prostitution. roscience and law. He discussed the insanity John B. Jemmott III, PhD was quoted in Caryn Lerman, PhD was cited in a July defense in a January 11, an April 8, 2011 Philadelphia Inquirer 21, 2010 Daily Pennsylvanian article* 2011 New York Times report* on Philadelphia Mayor Michael about a recent Penn study, which she co- report* about the mental health of the Nutter's new campaign against sexually authored, suggesting that additives in Arizona gunman, Jared L. Loughner, transmitted diseases. Dr. Jemmott led the ancient alcoholic beverages carried anti- who is accused of shooting Congressper- Philadelphia trial site for a program pro- cancer properties. The study showed that son Gabrielle Giffords and others in Ari- moting exercise and other healthy certain compounds in alcohol exhibit zona. He spoke with Time.com* about lifestyle habits to help prevent chronic activity against colon and lung cancer. incompetence to stand trial, also related disease. A study found the program to Her new study looking at how genetics to the Loughner case. be effective for black American couples play a role in smoking cessation was fea- in which one partner has HIV and the tured in a November 18, 2010 6ABC An Associated Press article in May 2010 other does not. Coverage appeared in (Philadelphia) report* in conjunction discussed attempts to change the under- U.S. News and World Report, Health Day* with Great American Smokeout Day. lying brain circuitry that leaves sub- (April 25), Medscape, and MedPage Research led by Dr. Lerman was high- stance abusers prone to relapse. With Today. lighted in a March 1, 2011 Wall Street funding from the National Institute on Journal story* about the FDA's considera- Drug Abuse, Charles P. O'Brien, MD, Deborah Kim, MD was tion of eliminating the warning to avoid PhD is studying that question in a interviewed* by WHYY long-term use of nicotine-replacement tough-to-treat population – prison (Philadelphia) on June 2, patches and gums. A study led by Dr. parolees. The AP article was posted by 2010 regarding a new Lerman identified a mechanism that the LA Times, Baltimore Sun, Newsday, study, which found that explains why people with a particular Orlando Sentinel, Miami Herald, Seattle pregnant women who take genetic background may be more prone Post-Intelligencer, Hartford Courant, and antidepressants during the to relapse when they try to quit smoking. Allentown Morning-Call, among others. first trimester may have an increased The research, published in the Proceed- Dr. O'Brien was also quoted in a July 28, risk of miscarriage. In the story, Dr. Kim ings of the National Academy of Science, 2010 Reuters article*, which reported that stated that while antidepressants may was highlighted by Time.com* (May 16), activists and scientists at the Internation- increase the risk of miscarriage, the over- Philadelphia Inquirer* (May 23), WebMD, al AIDS Conference in Vienna called on all risk is still low, and not taking med- Cosmos magazine, and by CBS News governments to stop criminalizing drug ications carries other risks, such as affiliates in cities around the nation. users and instead recommended that reducing the likelihood of receiving pre- they provide them with addiction and natal care and increasing the probability Irwin Lucki, PhD was interviewed by HIV treatment. Dr. O'Brien was inter- of substance abuse. Dr. Kim joined ABC LiveScience for an October 20, 2010 arti- viewed on December 7 on the "Kojo News Chief Medical Correspondent Dr. cle* regarding a gene therapy treatment Nmandi Show" on Washington DC's Richard Besser for a September 27, 2011 that cures mice of depression-like symp- NPR affiliate, WAMU Radio*, in a seg- twitter chat* focused on post-partum toms. According to the new study, this ment discussing the social effects of alco- depression. application of gene therapy could be the hol addiction. He was interviewed by the key to treating the blues in humans. In a November 2010 article* by Reuters LA Times in a May 23, 2011 article* about Health, Tanja V.E. Kral, PhD explained David S. Mandell, ScD was quoted in a the addition of "hypersexual disorder" a study she authored in The American May 25, 2010 Wall Street Journal article* and other addictions to the upcoming Journal of Clinical Nutrition which which noted that researchers are discov- edition of the Diagnostic and Statistical showed that when elementary school ering what occurs in the brains of babies Manual of Mental Disorders, called DSM-5, children did not eat breakfast on a single and young children with autism by tak- scheduled to be published in 2013. Dr. day, they did not make up for the missing scans of sleeping children. He was O'Brien was quoted in a Medscape arti- ing calories from breakfast by eating interviewed on a Phoenix radio statio, cle* about a study showing that more at lunch or throughout the remain- KTAR-FM, discussing the economic bur- gabapentin may help treat alcohol der of the day. den of caring for an autistic child. Dr. dependence. He was interviewed exten- Mandell spoke to WebMD.com for a sively for Time.com’s “Healthland” blog* Daniel D. Langleben, MD was inter- May 11 article* regarding his study (August 4) regarding alcoholism, with- viewed in a November 2, 2010 ABC- showing that having a child with autism drawal, and detox. News.com report* on the latest study to adversely affects family employment and explore how an MRI might be used to income. Coverage of the research also detect how honesty and deception affect Continued on page 35

www.med.upenn.edu/psych PAGE 35 www.med.upenn.edu/psych

Continued from page 34 R. Christopher Pierce, on the challenge for the approximately 10 6ABC (Philadelphia) for a July 14 story* PhD was quoted in a million U.S. adults with ADHD to main- about Casey Anthony's potential plastic November 17, 2011 tain focus. In addition, he told Comcast surgery options and the psychological WSJ.com article* on his Sportsnet that a combination of medica- impact this surgery could cause. Dr. Sar- study of how cocaine use tion and therapy can stop those with sui- wer commented in a July 27 Good Morn- can change the brain in cidal feelings from carrying them out. ing America/ABCNews.com report* ways that can be passed about a new study, which found that 33 on to male offspring, making them less David B. Sarwer, PhD frequently com- percent of nose job patients show signs of likely to find the drug rewarding. His mented on weight management issues body dysmorphic disorder, a chronic study is the first to show that the chemi- and treatments to induce weight loss in mental illness characterized by excessive cal effects of cocaine abuse can reach 2010 and 2011. Among his many contri- worry over appearance that interferes across succeeding generations to cause a butions to the public discourse, he was with daily life. Dr. Sarwer spoke about beneficial change, by altering how genes interviewed* on NBC10 (Philadelphia) on psychological repercussions in an August are controlled without actually changing July 29, 2010 to explain a recent study 8 New York Times report* about septuage- the genes themselves. Dr. Pierce present- that shows how resources on the web can narians, octogenarians, and nonagenari- ed his research, which used rat models, at act as an incentive to keep weight off. He ans undergoing elective plastic surgery. a meeting of the Society for Neuroscience was also quoted in a November 1, 2010 Dr. Sarwer was quoted in an October 31 in Washington, DC. Philadelphia Inquirer report* about the Wall Street Journal report* about the motivation to get a face-lift. Dr. Sarwer increase in elective cosmetic procedures In an interview* with ABC News’ Night- was interviewed by WHYY Radio among patients aged 65 and older. line on August 25, 2010, Adrian Raine, (Philadelphia) for a November 5, 2010 DPhil discussed his research on the story* about weight gain during the holi- Robert A. Schnoll, PhD was interviewed brains of people who have been scientifi- day season. CBS3 (Philadelphia) also by NBC10 (Philadelphia) in November cally determined to be psychopaths. He interviewed him about a new study 2010 concerning available treatments for was interviewed on CNN.com's “Paging which found that if at least four friends nicotine dependence. He spoke again Dr. Gupta” about freedom of will on Feb- are obese, one's odds of becoming obese with NBC10 for a January 13, 2011 story* ruary 22, 2011. The Chronicle of Higher doubles. He also commented in a January about the challenges of New Year's reso- Education profiled Dr. Raine, who has 23, 2011 MSNBC.com article* on a new lutions to quit smoking. spent a career trying to spot ever-earlier study that suggests eating a big breakfast signs of dangerous minds, in a June 12 may cause weight gain. Dr. Sarwer was An August 10, 2010 Philadelphia Magazine article*. quoted in a February 2011 W Magazine article* reported on local indulgences that story* about plastic surgery repeat proce- Philadelphia's nutritionists, including J. Russell Ramsay, PhD spoke with dures, where he noted that even success- Andrea Spivack, MA, RD, LDN, a regis- Reuters Health in an August 24, 2010 arti- ful procedures which satisfy the patient's tered dietitian with the Stunkard Weight cle* about a recent study, which found wishes may not adequately address the Management Program, cannot live with- that adults with attention deficit hyperac- patient's underlying concerns. He was out – and how to enjoy them without tip- tivity disorder (ADHD) who still have interviewed by CBS3 (Philadelphia) for a ping the scale. Ms. Spivack was symptoms despite taking medications story* looking at a new fad diet – the interviewed in a November 15, 2010 might benefit from "talk therapy," also baby food diet – which he would not rec- Philadelphia Inquirer article* about the known as cognitive behavioral therapy ommend, and discussed food labeling challenges baby boomers face with (CBT). Dr. Ramsay was interviewed by laws with the Philadelphia Daily News in a weight gain, diet, and exercise. Reuters Health for an October 16, 2011 March 31 article*. Dr. Sarwer spoke to NPR's "On Point" spoke story on The American Academy of Pedi- USA Today in a May 1 article* about atrics’ new clinical practice guidelines for with Andrew Strasser, research indicating that obesity is associ- PhD for a November 16, the diagnosis, evaluation, and treatment ated with reduced sexual functioning and of ADHD in children and adolescents. 2010 story* about the sexual quality of life. He spoke with the Food and Drug Adminis- HealthDay reported* on December 9, Detroit Free Press in a May 22 article* tration’s (FDA) pending 2010 on a NIMH-supported study by regarding the effects of bariatric surgery implementation of graph- Karl Rickels, MD in the December issue on marriage. Dr. Sarwer was quoted in a ic warning labels on cigarette packages. of the Archives of General Psychiatry, con- May 24 Wall Street Journal article* and a He also spoke on the same topic with cerning patients with generalized anxiety June 2 Huffington Post story* about the WJR radio (Detroit) on June 25, 2011, disorder who were treated for up to 18 increase in men seeking cosmetic proce- WFYI radio (Indianapolis) on June 28 on months with venlafaxine hydrochloride dures and the role that looks play in our its “Sound Medicine” program, and with extended release. lives. He was interviewed in a June 29 Indiana Public Radio (Indianapolis) on ABC "World News Tonight” segment* July 8. Dr. Strasser spoke on Philadel- Anthony L. Rostain, MD, about the American Medical Associa- phia’s plan to regulate point of sale ciga- MA wrote a letter* to the tion’s position that rampant Photoshop- rette warning displays on WHYY Radio editor, published in the ping sends an unhealthy message to (Philadelphia) on September 2, 2011. January 11, 2011 Philadel- America's youth. Dr. Sarwer also phia Inquirer, about the appeared as a featured expert in a June 29 Richard F. Summers, MD discussed cop- man accused of shooting WHYY (Philadelphia)/NPR segment* on ing in an October 13, 2011 Oprah.com Congressperson Gabrielle cosmetic surgery and discussed eating article*. Giffords and others in Arizona. Dr. Ros- disorders in adulthood with MSNBC.com The Concord Monitor interviewed Michael tain was quoted in a Health.com report* in a July 6 story*. He was interviewed by E. Thase, MD for a December 5, 2010 Continued on page 37

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 36 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

NEW FACULTY

Henry R. Kranzler, MD joined the Department in December 2010 as Professor of Psychia- try. He is Co-Director of the Center for Studies of Addiction, as well as Director of the Post- Doctoral Research Training Program for Physicians and Co-Associate Director of Research at the VISN 4 Mental Illness Research, Education, and Clinical Center (MIRECC) at the Philadelphia VA Medical Center. Dr. Kranzler received a BA in Anthropology from Monmouth University in 1976 and continued graduate work in the discipline, earning an MA from Rutgers University in 1980. Simul- taneously, he studied for his medical degree and received an MD from Robert Wood Johnson Medical School (UMDNJ) in 1982. He then completed a residency in Psychiatry at the Univer- sity of Connecticut in 1986, followed by a one-year National Institute on Alcohol Abuse and Alcoholism (NIAAA) Fellowship in Alcohol Studies. In 1987, Dr. Kranzler was appointed to the faculty of the University of Connecticut School of Medicine, eventually earning appointment as Professor in the Department of Psychiatry and the Department of Genetics and Developmental Biology before coming to Penn in 2010. A clinical addiction psychiatrist for more than 20 years, Dr. Kranzler now devotes his time to research, research administration, and teaching. His research focuses on the genetics and pharmacological treatment of alcohol and drug dependence and common comorbid psychiatric disorders, as well as studies of the pharmacogenetics of substance dependence. Dr. Kranzler's research has been continuously supported since 1987 by grants from the NIAAA and the National Institute on Drug Abuse (NIDA). He has authored or co-authored more than 350 journal articles, book chapters, and other publications. He chaired the NIAAA Clinical and Treatment Subcommittee (IRG), has been a frequent journal reviewer, and is a member of the editorial boards of six journals. Dr. Kranzler’s contributions to the field of alcohol research include advancing clinical trials methodology as it relates to pharmacological treatment, identifying interactive effects of serotonergic antidepressants with alcoholism subtypes, using a targeted approach to opioid antagonist treatment of heavy drinkers, and conducting the first studies of long-acting naltrexone as a treatment option for alcohol dependence. In addition, his work has contributed to the identification or character- ization of specific genes influencing the risk for dependence on alcohol, nicotine, cocaine, and opioids; the potential mechanism of the effects of alcohol through mediators such as neuroactive steroids; and genetic moderators of the response to alcohol treatment. Dr. Kranzler has received a number of awards and honors. He delivered a Frontiers of Science Lecture at the Annual Meeting of the American Psychiatric Association in 2006 and, in 2009, was elected a Fellow of the Ameri- can College of Neuropsychopharmacology and a Distinguished Fellow of the American Academy of Addiction Psychiatry. For the past decade, while in Connecticut, Dr. Kranzler was recognized annually in the publication Best Doctors in America.

Mathias Basner, MD, PhD, MSc joined the Department in January 2010 as Assistant Pro- fessor of Sleep and Chronobiology in Psychiatry. He is a member of the Department’s Division of Sleep and Chronobiology. Dr. Basner received a degree in Medicine (1999) and a PhD in Research (2001) from the Uni- versity of Bochum in Germany and, in 2006, a Master of Science in Epidemiology from the University of Bielefeld in Germany. He trained at the Institute for Applied Physiology at the University of Bochum and worked as a Research Associate at the German Aerospace Center (DLR), Institute of Aerospace Medicine, Flight Physiology Division in Cologne, Germany from 1999 until 2006. He then moved to the U.S. to pursue his research interests in the neurobehavioral consequences of sleep loss as a Research Associate in the Department of Psychiatry’s Division of Sleep and Chronobiology. In 2008, he returned to the DLR to head the Flight Physiology Division for two years before coming back to Penn and the Department in 2010.

Continued on page 37

www.med.upenn.edu/psych PAGE 37 www.med.upenn.edu/psych

Continued from page 36

Dr. Basner's primary research interests concern the effects of sleep loss on neurobehavioral and cognitive functions, population studies on sleep time and waking activities, and the effects of traffic noise on sleep and recuper- ation. He conducted several large-scale laboratory and field studies on the effects of traffic noise on sleep between 1999 and 2008 as Principal Investigator. For this research, Dr. Basner was awarded the German Aerospace Center award for outstanding research in 2007 and the Science Award of the German Academy for Aviation and Travel Medicine in 2010. Dr. Basner is Associate Editor of the journal SLEEP and is a reviewer for 21 professional journals. He is Secretary of the International Commission of Biological Effects of Noise (ICBEN). He is a member of the American Acade- my of Sleep Medicine (AASM), the Sleep Research Society (SRS), and the German Sleep Research Society (DGSM). Dr. Basner has been temporary advisor to the World Health Organization (WHO) concerning traffic noise effects on sleep.

Our Department in the News Continued from page 35 article* about transcranial magnetic stim- found that physicians, with the aid of regarding an article in Lancet and an ulation (TMS) as a treatment for resistant their medical assistants and meal- accompanying editorial on extended- depression. He was quoted in a Decem- replacement plans, can help obese people release, injectable naltrexone. ber 6 article* in US News & World Report lose and keep off 10 pounds over two about beating the holiday blues. Dr. years. The results were published in the Reporting on the mental Thase also spoke with Reuters Health for New England Journal of Medicine and cov- health of the 33 trapped min- a January 13, 2011 story* regarding erage has appeared in the Philadelphia ers in Chile, WHYY reports that people with long-lasting Inquirer, Washington Post, Los Angeles (Philadelphia) Radio inter- depression may benefit from talk therapy Times, Medpage Today, and Family Prac- viewed* Elna Yadin, PhD on when other treatment methods such as tice News. Dr. Wadden was interviewed August 24, 2010 to ask what the miners antidepressant drugs alone are not work- for a December 1 USA Today story* in can do to help lessen the traumatic ing. He commented in a Medscape arti- which he talked about insurance reim- impact of their situation. She said that cle on research from the Systematic bursement for obesity treatment and when we have a sense of lack of control, Treatment Enhancement Program for BD weight-loss options. that is when our mental health may be (STEP-BD) study, which found that the compromised. The miners will want to number of depressive or manic episodes The Philadelphia Inquirer reported in its be very active and busy, making their experienced by patients with bipolar dis- May 17, 2010 “Personal Health: News day-to-day passage of time meaningful. order (BD) predicts illness severity. Dr. and Notes” section* that compulsive In September, Dr. Yadin participated on Thase was quoted in a December 8 behaviors in some patients being treated TalkBlogRadio, a call-in program titled Reuters Health story* about patient for Parkinson's disease have been report- “It Can’t Just Be Me” on “OCD and response to antidepressant use. ed for decades. Daniel Weintraub, MD Hoarding.” In April 20, 2011, she was a led a large study supporting these obser- guest on The Barry Kirkey Radio Show, Marion Vetter, MD, RD, lead author of a vations that linked more types of out-of- “OCD”, broadcast from Toronto and, on recent study in the Annals of Internal control behavior with more Parkinson's June 1, she was featured on the New Medicine, was quoted* in Marie Claire drugs that are increasingly used for more York University Reji Mathew web inter- magazine about low-carb diets. disorders. In a July 12, 2011 story*, the view on “Running from Pain – Under- Wall Street Journal highlighted a study standing Post-Traumatic Stress Thomas A. Wadden, PhD discussed led by Dr. Weintraub which showed that, Disorder.” weight loss and positive coping strate- despite warnings about the risks of using gies in an August 1, 2010 Philadelphia antipsychotics to treat older, demented In an August 27, 2010 article* discussing Inquirer article* about Gov. Rendell's patients, the powerful drugs are routine- the recent egg recall, MSNBC inter- recent slim down. He was quoted in a ly prescribed to elderly people with viewed David Yusko, PsyD regarding November 16, 2010 Philadelphia Inquirer Parkinson's disease. HealthDay via US how people's fear and anxiety after a story* regarding attitudes toward obesi- News and WebMD.com also covered the food recall might change their eating ty. Dr. Wadden and David Sarwer, PhD story. habits. On September 3, 2010, WHYY were mentioned in a January 3, 2011 Radio (Philadelphia) interviewed* him Philadelphia Inquirer article* about the Kenneth J. Weiss, MD was interviewed about treatment options for PTSD. Dr. recent FDA advisory panel recommenda- in an August 5, 2010 CNN.com report* Yusko also participated in a 9/11 memo- tion to permit use of Lap-Band surgery about hoarding. rial show on RLTV titled "Honoring in thinner, but still obese patients. Dr. Flight 93.” He commented on the psy- Wadden led a study, reported in a George E. Woody, MD was interviewed chological impact of such an event on and quoted by Alcoholism Drug Abuse November 15 USA Today article*, which people. Weekly for a May 2011 publication

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 38 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Cornerstones Recognizing the significant achievements of our faculty and staff

ow does playing bass fiddle in a blue grass band the bass fiddle. We had a great time.” Only five years Hlead to three decades as a Penn faculty member and later, a friendship forged while making music was to to a distinguished career in obesity research? For Thomas influence Dr. Wadden’s future career and his choice of A. Wadden, PhD, the connection comes as no surprise. where to practice it. Dr. Wadden has spent a lifetime First, though, there artfully inter- was graduate train- weaving his per- ing in psychology sonal and FACULTY SPOTLIGHT at the University of professional North Caroli- interests while na at Chapel tackling perhaps Hill. Dr. Wad- America’s greatest Thomas A. Wadden, PhD den’s service health challenge. at Butler Hos- pital, along Dr. Wadden grew up in Washington, DC in with summers in college spent working a family where law and politics were tradi- with emotionally disturbed children and tions. His great-grandfather, a lawyer, was adolescents, convinced him that he want- a U.S. Congressman from North Carolina. ed to help others as a psychotherapist. His father was an assistant district attorney Graduate school, however, changed that and later a trial attorney. “My parents had goal, he says, where “I realized that pro- an abiding interest in politics,” he says, viding effective psychotherapy was more “which I inherited and now share with my complicated than I had first thought.” wife, Jan Linowitz, who also grew up in Washington in a very politically-minded The explosion in the number of untested family.” psychotherapies in the late 1960s and 1970s persuaded him to focus on research. Dr. Wadden expected to pursue the law “I was attracted to behavior therapy when he entered Brown University in 1971, because of its commitment to testing its but his curiosity as an undergraduate proposed interventions,” Dr. Wadden extended much further to include Bud- says. “And thus began my personal drive dhism, Hinduism, and the practice of medi- toward the identification of evidence- tation. As a sophomore, he took an based therapies. In short, to be an effective introductory course in psychology. therapist, I decided I needed to evaluate the therapies that I was going to provide.” “I was drawn to psychology as one of the helping profes- sions, and undoubtedly as a means of understanding the In his second year of graduate school, Dr. Wadden began turbulent times in which I had been raised,” Dr. Wadden his initial focus on obesity, mainly “because it provided recalls, linking his newfound interest with his “inherit- such an objective outcome measure – change in body ed” absorption in the affairs of the nation and world. weight,” he says. His first randomized controlled trial “Growing up in Washington, I had stood on Pennsylva- evaluated hypnosis as a means to induce weight loss. “I nia Avenue as an eight-year old to cheer President was intrigued by hypnotic suggestion,” he says, attribut- Kennedy on his Inauguration Day and then lived ing his interest to his college forays into Eastern religions through the scarier-than-hell Cuban missile crisis at age and practices. His first research study “revealed that ten. The ten years that followed were filled with anguish hypnosis was no more effective for weight loss than a and turmoil for our nation, and were particularly felt in treatment control group in which participants only prac- Washington.” ticed deep muscle relaxation therapy.” For his doctoral dissertation, he examined the use of relaxation therapy Now committed to psychology, Dr. Wadden received his for the control of essential hypertension and discovered bachelor’s degree from Brown in 1975 and spent the next that positive treatment expectations were critical to ther- year as a mental health aide at Butler Hospital in Provi- apeutic success. dence, Rhode Island. There he met Kelly Brownell, a psychology intern and now a well-known obesity and food Before leaving Chapel Hill with his PhD in 1981, Dr. policy researcher at Yale University, and Steven Hayes, Wadden met Dwight Evans, MD, then a psychiatry another psychology intern and later the author of intern at UNC, who worked in the outpatient unit to Acceptance and Commitment Therapy (ACT). “The three which Dr. Wadden was assigned for a practicum. That of us played in a blue grass band while at Butler,” says relationship was to re-emerge years later, as Dr. Evans is Dr. Wadden. “Kelly played guitar, Steve the banjo, and I now his Department Chair at Penn. Another connection, Continued on page 39

www.med.upenn.edu/psych PAGE 39 www.med.upenn.edu/psych

Continued from page 38

however, had more immediate conse- colleagues at the Center and the role in forcing commercial weight quences. “My continued focus on Department of Psychiatry loss programs to scrap inaccurate obesity was largely fortuitous,” he claims. Key to this was the first ever now says, tied to that Butler Hospital Dr. Wadden studies how obese and rigorous evaluation of a proprietary blue grass band. With his newly overweight individuals can best lose weight loss program, published in earned doctoral degree, Dr. Wadden weight – and keep it off. His research 1992. called Kelly Brownell, PhD, then has had widespread impact. In a Assistant Professor at the University series of studies with other Adopting his usual broad societal of Pennsylvania, who was working perspective, Dr. Wadden recognizes with renowned obesity expert Albert that the factors producing the current (“Mickey”) Stunkard, MD. Drs. obesity epidemic are not likely to dis- Brownell and Stunkard invited Dr. “Therapies for obesity appear soon. In a Fall 2007 Penn Psy- Wadden to Penn to do a postdoctoral have improved over the chiatry Perspective story announcing fellowship focused on obesity. the launch of the Albert J. Stunkard past 30 years, but they Weight Management Program, he “I thought I’d stay a year or two at remain modest,” Dr. pointed out that "the obesity epidem- most, because obesity did not seem ic is a result of our ancient genes. inherently interesting – just eat less Wadden concedes. The They protected us from starvation in and exercise more,” says Dr. Wad- Look AHEAD (Action times of famine, but we now live in a den. “But I got hooked on it very land in which food is plentiful, quickly with the help of two remark- for Health in Diabetes) cheap, and marketed to consumers able mentors, who approached the trial offers some cause around the clock. Eating has become problem from multiple perspectives for optimism, however. a recreational pastime that often has ranging from anthropology to psy- little to do with satisfying hunger or chology to physiology and genetics obtaining needed nutrition. At the and beyond.” same time, we have become an researchers in the 1980s and 1990s, he increasingly sedentary nation in Dr. Wadden thus embarked on his demonstrated that moderately which work, for many Americans, thirty-year obesity research career at restricted diets that induced a 10 to consists of little more than turning on Penn, interrupted for only a single 12 percent reduction in initial weight a computer and tapping on a key- year (1992-93) when he left Penn to were associated with better mainte- board. That's quite a change from Jef- become Professor of Psychology, nance of lost weight than were very- ferson's agrarian society in which Director of Clinical Training (in clini- low-calorie diets (VLCDs), which most American's expended hundreds cal psychology), and Director of the induced initial losses of 20 percent or of calories a day working on their Center for Health and Behavior at more. More recently, he showed that farms." Syracuse University. While he the combination of lifestyle modifica- enjoyed his 20 months at Syracuse, tion (behavior therapy) and pharma- “Therapies for obesity have “unimaginable” snow and “missing cotherapy produced greater short- improved over the past 30 years, but the stimulation provided by the and long-term weight losses than they remain modest,” Dr. Wadden world-class faculty at Penn Psychia- either approach used alone. concedes. The Look AHEAD (Action try” brought him back to Philadel- for Health in Diabetes) trial offers phia. Dr. Wadden and his collaborators some cause for optimism, however. have also contributed to an improved For the past 10 years, Dr. Wadden In 1994, Dr. Wadden returned to understanding of the effects of diet- has chaired the Lifestyle Intervention Penn as Professor of Psychology in ing on changes in energy expendi- Subcommittee for this multi-site trial Psychiatry and Director of the Center ture and neuroendocrine function. A of 5,000 overweight individuals with for Weight and Eating Disorders. In study published in the Journal of the type 2 diabetes. The study is investi- 2011, he was named the first Albert J. American Medical Association showed gating whether intentional weight Stunkard Professor of Psychiatry (see that resting metabolic rate declined loss reduces cardiovascular morbidi- accompanying story). He has built sharply during the first few weeks of ty and mortality. It is the first the Center into a highly regarded calorie restriction, an occurrence that prospective randomized trial to test hub of research on obesity and, with counteracts dieters’ efforts to lose whether intentional weight loss it, his own national and international weight. He observed similar reduc- reduces cardiovascular events. reputation for investigating obesity tions in the hormone, leptin, which treatments and leading randomized regulates food intake and body Initial results are promising. After controlled trials of interventions, weight. “Unfortunately for dieters, the first year of Look AHEAD, Dr. including diet, exercise, behavior the body resists weight reduction,” Wadden reports that the Intensive therapy, drug therapy, and bariatric he says. Lifestyle Intervention (ILI) group lost surgery. For the past 15 to 20 years, 8.6 percent of initial weight, com- he has carried out many of these True to his lifelong interest in public pared with a loss of 0.7 percent for studies with Robert Berkowitz, MD affairs, Dr. Wadden and his col- the control group. At four years, the and David Sarwer, PhD, two senior leagues have also played a visible ILI group maintained a loss of nearly Continued on page 40

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 40 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Continued from page 39 five percent of initial weight. “We and cravings, which may be related pre- and post-doctoral students in have not analyzed the data past this to changes in appetite-signaling hor- Psychology, as well as Psychiatry res- point,” Dr. Wadden says, ”but the mones resulting from the surgery,” idents. “Nothing has given me weight losses generally appear to be says Dr. Wadden. “Patients who greater pleasure in my work than holding at seven to nine years.” Par- undergo laparoscopic adjustable mentoring young researchers,” he ticipants have achieved this result says. “It’s always a thrill to help them through monthly behavioral treat- publish their first review article or to ment with their lifestyle intervention- “Treatment alone,” Dr. see them get excited about research. ist. “This long-term, continuous care Wadden emphasizes, The ultimate thrill is to assist them in model indicates that sustained weight preparing a successful grant applica- loss is possible, with ongoing treat- “whether lifestyle modi- tion and then to watch them conduct ment,” concludes Dr. Wadden. fication, pharmacothera- their research and publish their find- “Weight regain is not inevitable fol- py, or surgery, is not the ings.” Thinking of his own career lowing weight loss.” journey, he says, “I try to share with answer to our nation’s my pre- and post-doctoral fellows “Current efforts in the field are epidemic of obesity. We some of the superb mentoring that I focused on dissemination,” Dr. Wad- received from Mickey Stunkard and den continues, “to make lifestyle need to devote far greater attention and Kelly Brownell. And, it should go modification more available to the without saying that I learn as much millions of Americans who would resources to the preven- from my mentees as they do from benefit from it.” His research team’s tion of obesity.” me, particularly in areas such as the recent study, published in the New neuroendocrinological regulation of England Journal of Medicine, showed body weight. I will always be grateful that primary care physicians, work- banding, which does not affect these for the opportunity to have mentored ing with medical assistants, could hormones, may not experience equiv- young investigators, such as Gary help one-third of their patients alent improvements in appetite or Foster, David Sarwer, Drew Ander- achieve a clinically significant weight weight. We want to see if the two son, Suzanne Phelan, and Adam Tsai, loss of five percent or more of initial procedures are associated with differ- all of whom have gone on to become weight at two years. Dr. Wadden ent neural responses,” he says. top-flight, independent investigators. believes that interventions will Many other mentees are in the increasingly be delivered in commu- Circling back to his longstanding process of joining them.” nity settings, less expensive than interest in law and politics, Dr. Wad- medical clinics, and also will take the den believes that public health and Dr. Wadden is a prolific scholar, hav- form of smart phone applications. “In public policy initiatives are needed to ing co-edited six books and authored the near future,” he predicts, “your resolve the country’s obesity crisis. or co-authored more than 300 other phone will be able to provide an “Treatment alone,” he emphasizes, publications. He has been funded by hour-by-hour update of your physical “whether lifestyle modification, phar- the NIH for over 25 years, served on activity and food intake for the day macotherapy, or surgery, is not the the editorial boards of the leading and encourage you to go for the fresh answer to our nation’s epidemic of journals in his field, and has been fruit rather than cheesecake. Some obesity. We need to devote far selected for leadership roles at the will view it as electronic nagging!” greater attention and resources to the NIH as well as by professional organ- prevention of obesity. Ultimately, izations, most notably The Obesity The most important breakthrough for bold public policy initiatives and Society, where he served as President individuals with extreme obesity financial incentives, such as taxes on from 2005 to 2006. Dr. Wadden’s involves bariatric surgery, says Dr. sugared sodas, probably hold the work has earned him important acco- Wadden. “The gastric bypass reliably greatest hope for reducing the preva- lades from his peers, including the produces a long-term 25 to 30 percent lence of overweight and obesity.” 2007 Distinguished Alumni Award reduction in initial body weight, with from the Department of Psychology improvements in co-morbid condi- Dr. Wadden’s increased commitment at UNC-Chapel Hill, the 2007 Arthur tions such as type 2 diabetes.” Cur- to research has meant fewer hours K. Asbury Outstanding Faculty Men- rently, Dr. Wadden and Psychiatry seeing patients in recent years, but he tor Award from Penn’s Perelman colleagues Lucy Faulconbridge, PhD, still typically provides psychotherapy School of Medicine, and the 2009 David Sarwer, PhD, Marion Vetter, (e.g., cognitive-behavioral therapy) George Bray Founder’s Award from MD, RD, and Ruben Gur, PhD, along for weight and eating disorders to The Obesity Society. with Surgery colleague Noel two or three patients per week and, Williams, MD, are using functional with his postdoctoral trainees, assess- With a busy professional schedule, magnetic resonance imaging (fMRI) es candidates for bariatric surgery to Dr. Wadden still finds time for many to assess the effects of two different ensure that they are free of behavioral activities outside of work. “Two rise bariatric surgeries on appetite and contraindications to surgery. to the top,” he relates. “The first is reward centers in the brain. “Patients my immediate family, consisting of who undergo gastric bypass surgery Teaching is also a priority for Dr. my wife, Jan, and our three sons, report marked reductions in hunger Wadden, particularly supervising David, Michael, and Steven,” now Continued on page 41

www.med.upenn.edu/psych PAGE 41 www.med.upenn.edu/psych

Continued from page 40 ranging in age from 18 to 24 years. As a family, Dr. Wadden says, “We have a great time together, discussing politics or movies, playing music, watching the Daily Show, or just hanging out.” Psychology also is a staple of conversation. Jan works as a psycho-educational consultant with young children at the Anna Phoebe Thorne School at Bryn Mawr College. “Squash is my second passion,” Dr. Wadden says, “and I try to play three times a week. One of my biggest treats is playing squash with my sons.” After five years of weekly lessons, he still claims to be a “modest player.” “But I love the game and the camaraderie and fitness it provides,” he emphasizes. “Perhaps one day I’ll conduct a randomized trial of squash for weight control!” That would be an appropriate way to unite his personal and professional pursuits, nothing new for Dr. Wadden. After all, playing in a blue grass band some thirty-five years ago first put him on a road that eventually led to Penn and to becoming one of the nation’s outstanding obesity researchers.

Thomas A. Wadden, PhD Appointed Stunkard Professor

On September 23, 2011, the Department of Psychiatry salut- Bernard Sarnat International Prize in Mental Health from the ed two of its distinguished faculty members with a reception IOM. That year, he also received the Distinguished Scientist held in the Biomedical Research Building celebrating the Award from the Society of Behavioral Medicine at its 25th appointment of Thomas A. Wadden, PhD as the Albert J. Anniversary Annual Meeting. In 2007, he received the John Stunkard Professor of Psychiatry. Dr. Wadden is the first Scott Award from the Board of City Trusts of Philadelphia and chairholder of the Professorship, the Franklin Institute, a recog- which carries a ten-year initial term, nition earlier bestowed on customary for all endowed profes- such luminaries as Thomas sorships in the School of Medicine. Edison, Madame Curie, the Wright Brothers, and Jonas The Stunkard Professorship is des- Salk. ignated for the Department of Psy- chiatry “with a preference for At the September 23 recep- someone in the area of Weight and tion, J. Larry Jameson, MD, Eating Disorders and Behavioral PhD, Executive Vice President Health.” This is a most fitting of the University of Pennsylva- emphasis because Dr. Stunkard, a nia for the Health System and member of the Department since Dean of the Perelman School 1957, has been a seminal figure in of Medicine, and Department both fields. For over half a century, of Psychiatry Chair Dwight L. his eclectic research interests have Evans, MD spoke about Dr. opened new lines of inquiry on the genetic, psychological, Stunkard’s extraordinary accomplishments over his most pro- therapeutic, and developmental aspects of multiple eating dis- ductive career. Dr. Evans summarized his achievements this orders and human obesity. As significant, he and other Penn way: Psychiatry faculty helped define behavioral medicine as an area of intellectual endeavor in the late 1970s. “Mickey is a revolutionary and a pioneer. He revolu- tionized our understanding of obesity and his career is Dr. Stunkard, known as “Mickey” to friends and colleagues, is marked by a series of firsts. He was the first to descibe the author of over 500 publications and his research has the powerful environmental effects of social class on been supported for over fifty years by the National Institutes obesity, and through the study of identical twins, the of Health. He has served as Past President of the American first to describe the powerful effects of genetics. He Association of Chairmen of Departments of Psychiatry, the also was the first to describe binge eating disorder, as Association for Research in Nervous and Mental Diseases, well as the first to describe night eating syndrome.” the American Psychosomatic Society, the Society of Behav- ioral Medicine, and the Academy of Behavioral Medicine Dr. Stunkard’s impressive and historic legacy honors the Pro- Research. He also serves on the editorial boards of seven fessorship that bears his name, the University of Pennsylva- journals in the fields of nutrition and behavioral medicine. He nia and the Department of Psychiatry, his home for over five is a former Chair of Penn’s Department of Psychiatry. decades, and the first Stunkard Professor, Dr. Thomas Wad- den, who has firmly secured his own place in the weight and Among the many awards bestowed upon him, Dr. Stunkard eating disorders field. has been elected to the Institute of Medicine (IOM) of the National Academies and, in 2004, he received the Rhoda and

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 42 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

didn’t develop a true interest in Mathematics competed for his attention, The year away from the formal under- “Iclinical psychiatry until the latter however. His “love” for theoretical graduate medical education program half of medical school,” says Jared Ell- mathematics first developed in high helped him confirm his career interests school and he fostered it at Johns Hop- in medicine and psychiatry, specifically man, MD. “It was the work with kins, where he worked as a teaching psychotherapy, and, ironically, affirmed patients on the units at HUP [Hospital assistant and tutor in the mathematics his desire to work directly with patients of the University of Pennsylvania] that in a clinical set- was most power- ting. “It was help- ful for me.” ful to gain experience with Fifteen years later, VOLUNTARY FACULTY PROFILE the process of Dr. Ellman’s inter- conducting actions with clinical patients continue to fortify Jared Ellman, MD research and his commitment to his cho- publishing,” sen specialty. Today, Dr. Dr. Ellman says, “but my main interest Ellman is a Clinical Assistant Professor was always clinical. The clinical experi- in the Department of Psychiatry, a pop- ences I [later] had on my psych rota- ular and valued member of the volun- tions solidified my thinking about it and tary teaching staff, and an active encouraged me to finish.” psychiatrist in Center City Philadelphia with a diverse and busy practice. He has Dr. Ellman received his MD from Penn achieved this stature in a profession that in 1998. Now committed to both medi- he cherishes, but his road to psychiatry cine and psychiatry, Dr. Ellman ulti- was not a linear one. mately chose Penn for his residency training in psychiatry. “I didn’t original- Dr. Ellman grew up in Port Jefferson ly think I would stay at HUP for resi- Station on Long Island’s North Shore, dency training,” he remembers. “The about an hour east of New York City. time of my application coincided with He chose Johns Hopkins University for the closing of the Institute of Pennsylva- college. “My decision to attend Johns nia Hospital, which was one of the pre- Hopkins was somewhat random,” he eminent psychotherapy training acknowledges. “It was mostly based on hospitals in the country, and the migra- the aesthetics of the campus, and college tion of many of its faculty to HUP. Hav- campus tour fatigue,” he adds with a department, and graduated with a BA ing developed a strong interest in smile. “I didn’t put as much thought in mathematics in 1993. “I probably psychotherapy, the ability to work with into that decision as I might have, but it would be teaching math in some capaci- these supervisors was a major factor for worked out because the pre-med pro- ty, if I hadn’t found psychiatry,” he me. I was also excited to continue rela- gram there was strong and I enjoyed my reflects. tionships with members of the faculty time in Baltimore.” But he did find psychiatry – ultimately. who had mentored me as a medical stu- Dr. Ellman joined the pre-med program Dr. Ellman chose the University of dent, including Dr. Barber, Stanley upon entering college, primarily to Pennsylvania School of Medicine for his Caroff, MD, and William Ball, MD.” retain the option of a career in medicine. medical education, swayed by Penn’s Dr. Ellman’s Penn mentors over the His nascent interest in medicine, and in reputation and proximity to New York, years have had a substantial impact on psychiatry, stemmed from a televised allowing for easy visits to friends and his career, and he graciously credits Long Island trial he viewed while a family. Yet, he was not fully convinced them. “There are many people in the teenager. During the proceedings, a psy- that medicine was the right path for Department who acted as mentors at chiatrist testified about the effects of him. Following his second year, he different points in my career,” he says. acute trauma and how traumatized peo- spent a year away from the medical cur- “One major influence was Rick ple might be susceptible to coerced con- riculum working with Jacques Barber, [Richard] Summers, MD.” Dr. Summers fessions. To this day, he remembers PhD in the Center for Psychotherapy co-directs the residency program, teach- “admiring the psychiatrist's insight and Research in the Department of Psychia- es the psychotherapy didactic curricu- how an understanding of the human try. He co-authored a paper with him lum, and served as Dr. Ellman’s mind can reframe one's perspective on a on short-term dynamic psychotherapy individual supervisor during his resi- situation.” He thought then that “it that was published in Current Opinion in dency training and early years of pri- would be rewarding to learn more Psychiatry. “My connection to the idea of vate practice. “He has always been a about this and to work in a field where I being a doctor really developed while I role model for me and someone after could help others.” At Johns Hopkins, was in medical school,” he says. “How- whom I’ve modeled my career,” Dr. Ell- he ventured into the brain sciences dur- ever, for a time in med school, I was man emphasizes. “Among many other ing his senior year by working as a questioning my decision to continue things, I’ve learned from Rick the research assistant in a brain imaging lab with medicine – that was part of why I nuances of balancing a formal- in the psychiatry department. took a year out.” Continued on page 43

www.med.upenn.edu/psych PAGE 43 www.med.upenn.edu/psych

Continued from page 42 ized/medical approach to treatment Dr. Ellman views his connection with the with non-MD clinicians; the time I spent with a humanistic, relationship-based patient as critical for a successful treat- working at the Center for Psychotherapy mindset, as well as balancing a private ment outcome. “My psychotherapeutic Research informs that process still.” practice focus with other professional style is focused primarily on the thera- endeavors. Rick has also encouraged my peutic relationship and its use as an Being at Penn also enables him to teach role as an educator in the department.” agent of change,” he explains. “I guess and mentor psychiatry trainees, and help you might call that a psychodynamic or others as others have guided him. Over Dr. Barber, who recently left Penn to the past ten years, Dr. Ellman has estab- become Dean of the Gordon F. Derner lished himself as an important contribu- Institute of Advanced Psychological “The ability to interact with tor to the Department of Psychiatry’s Studies at Adelphi University, also had a researchers regularly is teaching program. Today, he supervises major influence on his career develop- residents on psychotherapy cases, men- ment. “He has helped me understand the one of the benefits for me tors PGY-4 residents on early career importance of self-reflection and person- of being at an academic issues, serves as a mock boards examin- al growth in becoming an effective thera- center,” Dr. Ellman says. er, interviews and evaluates residency pist,” says Dr. Ellman, “and has also “Integrating scientific applicants, and leads psychotherapy case been a great sounding board for profes- discussions. sional and personal issues.” research with an experiential approach is something Carving out time from his busy practice, Dr. Ellman completed his Penn psychia- I think about a lot in my he devotes one to two hours per week to try residency in 2002 and entered private resident training. “I enjoy doing this practice. He has maintained his psychia- practice.” very much,” Dr. Ellman enthuses. “The try practice for the past decade, while on residents at Penn are so bright, enthusi- occasion doing staff and consulting work astic, and eager to learn – especially with several area institutions, including interpersonal approach. I try to use my about psychotherapy. Teaching also the Westchester University Counseling true self in therapy as much as possible helps me organize my clinical thinking – Center, Hall Mercer Community Behav- in order to encourage the same in my and questions asked by residents help ioral Health Center’s Crisis Response patients. That being said, I also employ me consider issues I might not have oth- Center at Pennsylvania Hospital, Ren- more specific techniques such as those erwise. I really enjoy doing psychothera- frew Center for Women’s Mental Health, derived from cognitive behavior therapy py supervision and leading case Villanova University Counseling Center, when indicated. More recently, I have conferences – getting into the details of a and the Consultation-Liaison Serv- developed interest in mindfulness, medi- case and helping residents think through ice/Psychiatric Emergency Room at tation, and visualization techniques, complicated therapeutic issues is very HUP. “Working these other jobs,” Dr. which I have been starting to employ fun for me. I love helping trainees think Ellman says, “has helped me further my more frequently. I’ve always found that through issues of transfer- understanding of certain treatment the strength of the relationship in psy- ence/countertransference – I think this is modalities – such as working with eating chotherapy correlates with treatment an area where a supervisor can be espe- disorder patients at Renfrew – and also success more than therapeutic orienta- cially valuable.” helped develop a broad professional net- tion – although I’m sure some research work, which helps my practice.” would say otherwise.” Outside of work, Dr. Ellman enjoys doing yoga, martial arts, seeing live Dr. Ellman’s practice is diverse, a In 2003, only a year out of his residency, music, and performing improv comedy. description of both the patients he sees Dr. Ellman sought to continue his con- He is also a recently certified level one and the treatments he employs. His nection with Penn, and he was appoint- practitioner of Reiki, a Japanese tech- patients vary demographically as well as ed Clinical Assistant Professor of nique for reducing stress and promoting in terms of level of functioning and treat- Psychiatry. He greatly values this affilia- relaxation and healing. “Family wise,” ment needs. Dr. Ellman’s broad experi- tion and recognizes its multiple benefits, he underscores, “I’m recently married ence with a variety of psychotherapeutic which include sharing ideas with psychi- with a child on the way!” A life already modalities is essential for developing atric thought leaders and training out- packed with a busy clinical practice, appropriate treatment plans. standing residents. Moreover, his work teaching responsibilities, and personal with Penn psychiatrists and psycholo- pursuits is about to get even more “Having interest in and experience prac- gists has exposed him to new therapeutic crowded. ticing psychotherapy – in addition to perspectives and ideas, with potential biological treatments – opens up the pos- benefit to his patients. But it is certain that Dr. Ellman will con- sibility of intervening for a more diverse tinue to find time for his patients and the set of issues,” Dr. Ellman says. “I aim to “The ability to interact with researchers profession he ultimately selected and feel confident in handling any type of regularly is one of the benefits for me of now cherishes. As he says with convic- issue that one might experience. being at an academic center,” he says. tion, “I’m happy to have made this choice – Whether the intervention would be a “Integrating scientific research with an it’s been very beneficial for me to prac- complicated medication regimen, psy- experiential approach is something I tice a specialty that fosters individual chotherapy alone, or a mindful- think about a lot in my practice. I also growth and promotes a deeper under- ness/meditative approach, I try to stay focus on the process of collaboration standing of people and relationships.” competent in all types of treatment.”

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 44 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

arol Holmes’ health care career, spanning more one of the nursing supervisors at the hospital asked her Cthan two decades including eight years in the to move with her to Presbyterian Medical Center in Department of Psychiatry, confirms that doing a great Philadelphia. She made the move to Presbyterian in job leads to recognition and very good results. January 1995, shortly before the hospital became part Although Ms. Holmes retired from the Department in of the University of Pennsylvania Health System. The January 2012, her Carol Holmes-Penn con- legacy of outstanding nection had begun. service and dedication lives on. At Presbyterian, Ms. EMPLOYEE SNAPSHOT Holmes Ms. was a Uti- Holmes lization was born Carol Holmes Review in Assistant, Philadel- with a phia and, except for a year in Miami as focus on Medicaid patients in the a child and a few months in Baltimore inpatient Substance Abuse Unit. after high school, she has always made Again, her good work made an the Philadelphia region her home. She impression. Elizabeth Hooten was graduated from Springfield’s Cardinal then the Director of Utilization, Med- O’Hara High School in 1967 and, short- ical Records and a few other depart- ly after returning from Baltimore in Jan- ments at the hospital. A few months uary 1969, she began work as a Unit after she accepted another position in Clerk at Delaware County Memorial the Penn Health System, Ms. Hooten Hospital, her first health care position. asked Ms. Holmes to join her and, in One of the hospital physicians just October 1998, Ms. Holmes became starting a practice in Drexel Hill offered Department Secretary for the Office of her a part-time position. “Being young Clinical Practices of the University of and single,” she says, “I had the time so Pennsylvania (CPUP) Patient Services. I took the position as a second job. It Soon, she was doing double-duty for a soon became full-time and I began to assist with three-month period by simultaneously taking on the patients.” position of Executive Assistant in the Office of the CPUP Interim Executive Director. Finally, the executive The physician recognized Ms. Holmes’ potential and positions were sorted out and, in December 1998, she suggested that she consider becoming a Physician became the Executive Assistant to Tom Martin, the Assistant. She started a training program at Thomas CPUP Associate Executive Director. Jefferson University, but shortly after beginning the program, she was pregnant with twins. “It became a The Executive Assistant position brought with it many difficult pregnancy,” she says, “so I was unable to com- new responsibilities, and Ms. Holmes modestly plete the program.” After Jason and Julie were born in remembers, “I was very inexperienced but people were 1972, she became a full-time stay-at-home mom and, kind and patient with me.” She liked the position and for eighteen years, devoted her energies to her husband the challenge it brought. “I really liked the people that I Mike and their growing family, which came to include was working with and I enjoyed learning new skills,” Jenny, John, and Joshua, as well as the twins. she emphasizes. “I especially liked getting to know the CPUP Business Administrators.” By 1990, Jason and Julie were in college and the youngest child Joshua was in school full-time. “I Getting to know Rosellen Taraborrelli, then the Chief enjoyed the quiet for a month or so,” Ms. Holmes Financial and Administrative Officer in the Department recalls, “but I was thinking I might want to go back to of Psychiatry, proved especially important. When Ms. school to become a Physician Assistant after all.” To Taraborrelli restructured her Executive Assistant posi- test the waters, she went back into the work force, tak- tion in 2003, Ms. Holmes made the move to Psychiatry ing a position as Unit Secretary at Mercy Haverford after five years in CPUP. “Rosellen was always one of Community Hospital, five minutes from home. my favorite BA's,” says Ms. Holmes, “so it was a ‘no- brainer’.” Also true, her outstanding work again “I thought the position would give me a chance to get earned notice from a colleague. back into the medical field and help me decide if I wanted to go back to school,” Ms. Holmes says. “It Among many responsibilities, Ms. Holmes’ work as turned out that I really loved the job and the people at Executive Assistant included her special assignment as Mercy Haverford so I never did get back to school. I Captain for the Department of Psychiatry's United Way enjoyed working close to home and made some friend- (now Penn’s Way) Campaign on the CPUP side, begin- ships that have lasted through the years. The nurses ning in 2003. “When Rosellen became the CPUP Cam- that I worked with then still keep in touch and we get paign administrator for Penn's Way,” Ms. Holmes says, together a couple of times every year.” “I became the CPUP Coordinator and we have continued in this role ever since.” Her duties, which she Once again, her outstanding work drew notice, and shared with Natalie Conlin, included preparing status Continued on page 45 www.med.upenn.edu/psych PAGE 45 www.med.upenn.edu/psych

Continued from page 44 reports and communicating with and answering ques- As she reflects back on her professional career, Ms. tions from CPUP Captains. Ms. Holmes says with consid- Holmes says it “loud and clear” that, while she enjoyed erable pride, “It is satisfying to know that the campaign other positions, “my work in the Department is far and provides funds to agencies that really make a difference away my favorite.” Does she have any recollections that to those in need.” stand out? “I think the holiday celebrations are among my most special memories,” she says, and adds this It is no surprise that, once again, Ms. Holmes’ contribu- about the person who brought her into the Department. tions were noticed. Ms. Taraborrelli says that “she was “Rosellen is an amazingly generous person and she indispensable. I could only carry out my system-wide always makes holidays special for the staff. I think Penn’s Way responsibilities because I had Carol. All of Rosellen is a phenomenal leader and I admire her the Captains across the Health System went to Carol for tremendously.” guidance!” With a well-deserved retirement from the labor force now In July 2008, to fill a departmental need, Ms. Holmes in her immediate future, Ms. Holmes thinks about lessons moved to another position within the Department, when learned over her working career. “I have learned that I she became Manager in the Office of Network Develop- am not perfect,” she says, “but that I am able to learn and ment for Provider Relations and Credentialing. In this grow. Always do your best and let the little things go.” role, among other responsibilities, she helped ensure that providers in the Penn Behavioral Health network were Retirement offers Ms. Holmes the opportunity to do more properly credentialed and re-credentialed and she assist- of what she has always enjoyed outside of work. “I enjoy ed the Director of Contracts and the Director of Clinical reading, traveling and volunteer activities,” she says.” Operations to determine the network need for providers “Most of all, I enjoy spending time with our family, espe- by type and location. “Credentialing is the part I liked cially spending time with our grandchildren and watch- best,” Ms. Holmes says about this position. “I enjoyed ing them grow up.” There will be much more time for all reviewing the various backgrounds of our providers and of that. working with our provider groups.” In leaving the Department after eight years, Ms. Holmes Just as her good work was noticed, Ms. Holmes’ absence wishes to express her deep appreciation for her col- will be, too. Ms. Taraborrelli summarizes it all in saying leagues in Psychiatry. “My time in the Department of that “Caroline Hamilton Dolan [Director of Finance, Psychiatry has been very rewarding,” she says. “I would Department of Psychiatry and Penn Behavioral Health], like to thank everyone I have worked with over the years. Paul Rusch [Director of Contracts, Marketing & Product It has been a pleasure to get to know you and a privilege Development, PBH], and I are so used to having her as a to work with you. I wish you all continued success both ‘go-to person’ that we will miss her very much.” personally and professionally.”

Jeanne Blackman Retirement Party

On September 16, 2010, the Department of Psychiatry hosted a retirement party for Jeanne Blackman. During a long career – extending over 50 years at Penn – and 48 years in the Department, Ms. Blackman Wade H. Berrettini, MD, PhD with Jeanne worked for several Chairmen, including Albert J. Stunkard, MD; John Paul Brady, MD; George Ruff, MD (Acting Chairman); Peter C. Whybrow, MD; and Gary Gottlieb, MD (Inter- im Chairman). She also worked with faculty in the Center for Neurobiology and Behavior, Jeanne with the wall of New including Director Wade H. Berrettini, MD, York Times front pages PhD. (Please see the Employee Snapshot marking historical events during her decades at Penn article in the Spring 2008 issue of Penn Psy- chiatry Perspective for a brief look of Ms. Blackman’s life and career.) Jeanne with Albert J. Stunkard, MD

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 PAGE 46 PENN PSYCHIATRY PERSPECTIVE SPRING 2012

Educational Highlights CORNER

’ he 2011-2012 academic year got off to a great

S Tstart this summer as our interns began their work as new physicians. The Class of 2015 repre- T sents diverse backgrounds and interests, and hail

N from eight different medical schools, but maintain

E the collegiality and dedication to one another that Penn Psychiatry residents are known for. The PGY-

D 2 class was delighted to welcome two new resi- I dents to their class as well – Simmie Foster, MD, by Chief Residents S PhD joined them after completing her intern year from left: John Northrop, MD, PhD; Adam Meadows, MD; E in Internal Medicine at Massachusetts General Eleanor Ainslie, MD; and Laurie Gray, MD

R Hospital, and Rahim Rahemtulla, MD came on board through the Peds Portal program with future plans for a career in Child and Adolescent Psychiatry. We held the 2nd Annual Residency Colloquium in July, which was a great opportunity for residents and faculty to engage in rich discussion about the current ‘hot topics’ in psychiatry. This year’s session covered controversial issues involving neuroethics and the law, the use of antipsychotics in children, the validity of non-chemical addictions, the use of cognitive enhancers, how to classify suicidal behavior, choosing a type of psychotherapy, and the effects of health care reform on psychiatry. It was a very spirited and informative event and we are looking forward to continuing this tradition in years to come. As the fall season approached, the PGY-3 and 4 residents settled into their roles within the outpatient clinics. This is the first full year of using EPIC, the new electronic medical record, which has been a great tool to help streamline record-keeping and facilitate improved communication among providers within the Health System. While the outpatient residents had to say good-bye to two instrumental educators in the outpatient clinic, John O’Reardon, MD and Ben Nordstrom, MD, the residents were very excited to welcome three new faculty to the outpatient clinic. Jorge Rivera, MD, Ted Satterthwaite, MD, and Sarah Mathews, MD lead clinics in general psychiatry, treatment resistant depression, and anxiety disorders, respectively, and the residents have appreciated the new clinical and educational perspectives they have added to their training. Now we are midway through the year, and the fourth-year residents are beginning to develop their plans for life after graduation. John Northrop, MD, PhD, chief resident for HUP, Philadelphia VA Med- ical Center, and affiliate sites, has accepted a position in the Forensic Psychiatry Fellowship here at Penn next year. Laurie Gray, MD, outpatient chief resident, is exploring fellowship opportunities in Boston for Child and Adolescent Psychiatry. Adam Meadows, MD, chief resident for Pennsylvania Hospital, is planning to join a group practice in Atlanta. Eleanor Ainslie, MD, chief resident for medical student education, has accepted a fellowship in Consultation-Liaison Psychiatry here at Penn. Mia Everett, MD is exploring fellowship opportunities for Child and Adolescent Psychiatry in Philadelphia and New York. Bianca Previdi, MD is considering a fellowship in Addiction Psychiatry or further work in psychodynamic psychotherapy. Mario Cristancho, MD plans to continue his research career in mood disorders. Michelle Moyer, MD is contemplating additional training opportunities. Abraham Pachikara, MD is exploring practice opportunities in Philadelphia. The residency program has also recently begun its recruitment season to resume the process of selecting the next exceptional class of Penn Psychiatry residents. In April, the current chief residents will be looking to pass the torch to a new set of chiefs who will continue the work of improving the program and realizing our goals. We are optimistic that the year will finish in the same strong fashion that it began.

www.med.upenn.edu/psych PAGE 47 www.med.upenn.edu/psych

INTRODUCING THE Forensic Psychiatry RESIDENT CLASS OF 2015 Fellowship Program

he Department of Psychiatry welcomes the class Tof 2015 (pictured below) to the residency train- Robert L. Sadoff, MD continues to direct the ing program. The current class of interns in Psychia- Forensic Psychiatry Fellowship Program, now in its try was chosen from 755 applicants of whom 88 third year. Kenneth J. Weiss, MD is the Co-Direc- were actually ranked. These 10 individuals are tor of the program. Octavio Choi, MD, PhD and Elena del Busto, MD are the current fellows in the extremely talented young doctors who were at the 2011-12 academic year. Susan Rushing, MD, JD top of their medical school classes and who demon- and Zachary Torry, MD were the fellows during the strated a strong commitment to the field, as well as 2010-2011 academic year. great leadership potential. They began their residency training on June 20, 2011. This year's recruitment efforts began on September 1st and continued until January 31, 2012.

Katharine Baratz Dalke, MD Carina Behrens, MD University of Pennsylvania University of Pennsylvania from left: Robert L. Sadoff, MD, Elena del Busto, MD Octavio Choi, MD, PhD, and Kenneth J. Weiss, MD

Adrienne Clark, MD Yu-Heng Guo, MD Psychiatry Residents University of Pittsburgh Drexel University Class of 2011 Graduation Ceremony

June 10, 2011

Timothy Kreider, MD, PhD Anup Sharma, MD, PhD Univ of Medicine & Dentistry, NJ University of Pennsylvania

Andrew Siegel, MD Erica Smolcic, MD Sackler School of Medicine Penn State University

Front row, from left: Karla M. Campanella, MD; Holly Valerio, MD; Lauren Elliott, MD; Andrea Bowen, MD Middle row, from left: Dwight L. Evans, MD (Chairman); Richard F. Summers, MD (Co-Director of Residency Training); Rebecca Aspden, MD; Rachel Bennett, MD; Anthony L. Rostain, MD, MA (Director of Education) Thomas Suberman, MD Catharine Wolfe, MD Back row, from left: Christopher Tjoa, MD; Samuel Collier, MD; University of North Carolina Louisiana State University David Danish, MD; Donavan Maust, MD

PENN PSYCHIATRY PERSPECTIVE SPRING 2012 Non-Profit Org. U.S. Postage PAID Department of Psychiatry Permit No. 2563 Office of the Chairman Phil., PA 19104 3 Blockley Hall 423 Guardian Drive Philadelphia, PA 19104-6021 Telephone: (215) 662-2818 Fax: (215) 662-6911 URL: www.med.upenn.edu/psych

PENN PSYCHIATRY PERSPECTIVE URL: www.med.upenn.edu/psych/newsletter Editor: Rosellen Taraborrelli Telephone: (215) 662-2899 E-mail: [email protected] To make a gift to the Department of Psychiatry, please contact: Writing and Design: Michael L. Balaban Williams-Campbell Administrative Services, LLC Penn Medicine Development & Alumni Relations 3535 Market Street, Suite 750 Philadelphia, PA 19104-3309 Telephone: (215) 573-4028 Email: [email protected] URL: www.med.upenn.edu/psych/support