PENN Fall 2006 Psychiatry Perspective

Aaron T. Beck, MD 2006 Albert Lasker Clinical Medical Research Award aron T. Beck, MD, Uni- fastest growing short-term Aversity Professor Emeri- psychotherapy in the world. In This Issue tus of Psychiatry, is the Since 1954, Dr. Beck has been recipient of the 2006 Albert a faculty member in Penn’s Lasker Clinical Medical CHAIRMAN’S REPORT ...... 2 Department of Psychiatry, an Research Award, considered PROGRAM HIGHLIGHTS association that has proved the most prestigious honor Pain Medicine ...... 3 beneficial to his path-breaking bestowed in American sci- Behavioral Genetics ...... 5 research. “I have been partic- ence. Called “America’s OUR DISTINGUISHED FACULTY ularly helped by the warm Nobel,” the Lasker Award is Awards and Honors ...... 7 atmosphere in the Department often a precursor of a Nobel News & Goings-On ...... 9 toward clinical research dating Research News ...... 11 Prize. Since the first Lasker back many decades to the Research Grants ...... 14 Award was conferred in chairmanships of Dr. Kenneth Faculty in the News ...... 16 1962, 71 awardees have later Appel (1953-1962) and Dr. CORNERSTONES won a Nobel. Albert Stunkard (1962-1973),” he says. Faculty Spotlight ...... 17 In a stellar career stretching over five Voluntary Faculty Profile . . . . .19 Dr. Beck views the Lasker Award as more decades, Dr. Beck revolutionized the psy- Employee Snapshot ...... 21 than personal recognition. “This award chological understanding and treatment EDUCATIONAL HIGHLIGHTS acknowledges that psychological of depression and other psychiatric disor- Resident Class of 2010 ...... 22 approaches to the understanding and ders, pioneered the development of Cog- Resident Activities ...... 23 treatment of mental ills presents a scientif- Family Systems Program . . . . .24 nitive Therapy to treat these maladies, ically valid form of investigation,” Dr. developed sophisticated instruments for DEPARTMENT PICNIC ...... 26 Beck emphasizes. “Specifically, it recog- assessing the severity of specific psychi- CALENDAR OF EVENTS ...... 27 nizes the value of Cognitive Therapy in atric syndromes, and continues to make clarifying and ameliorating various prob- seminal additions to our understanding of lems.” suicide classification, assessment, predic- tion, and prevention. The School of Medicine is holding a recep- tion to honor Dr. Beck on November 6 at Dr. Beck, featured in the Faculty Spotlight the Union League, 5:00-7:00 pm. All column in the Winter 2006 issue of Penn Department of Psychiatry Department faculty and staff are invited and Psychiatry Perspective, is widely known as PENN Behavioral Health to attend. Please contact Tina Callaghan the “Father of Cognitive Therapy,” the University of Pennsylvania at (215) 662-2818 for details. O Communicating better... enn Psychiatry Perspective has a new look. We have created distinct sections within the newsletter and have utilized a two- or Pthree-column page structure to make it easier to locate our features and read our stories. We have also added the portrait of Benjamin Rush to our cover page. Rush, the first Chair of Chemistry in America and one of the earliest teachers in Penn’s medical school, was the world’s leading expert on mental diseases in the late 18th and early 19th centuries. In 1812, Rush published Med- ical Inquiries and Observations Upon Diseases of the Mind, the first American textbook of psychiatry. Rush is recognized as the “Father of American Psychiatry.” We have also redesigned the Department web site to improve ease of use and to expand the information available to users. Start- ing in November, the new web site address will be: www.med.upenn.edu/psych. This and future issues of Penn Psychiatry Per- spective will be posted on the web site. Also, we are developing a new web site for the Department’s residency program, to be launched in November (www.med.upenn.edu/psychres). O PAGE 2 PENN PSYCHIATRY PERSPECTIVE O FALL 2006

Chairman’s Report

bout a decade ago, biomedical researchers began to the recipient of the presti- Ause a term which succinctly describes what we do. gious 2006 Albert Lasker According to the NIH, translational research is the process Clinical Medical Research by which “scientific discoveries [are] translated into practi- Award. Over five decades, cal applications.” all spent in our Department, Dr. Beck developed the theo- Translational research is the place where science and medi- ry and practice of cognitive cine meet to conquer disease. therapy, used world-wide to Conducting research to improve patient care is one of the treat patients suffering from fundamental reasons why academic medical centers and a wide range of mental and departments such as ours exist. How well we create knowl- medical disorders. edge to improve the public health largely determines our Clinical Research – At the value to society and our reputation among our peer clinical research end of the departments. investigative spectrum, faculty in the Neuropsychiatry Sec- Translational medicine takes many forms, from laboratory tion, including the newly established Center for Transla- or “bench” research to studies of human subjects, and vice tional Research in Psychiatry and the Center for Neu- versa, with the same goal – improved drugs, therapies, and roimaging in Psychiatry, study brain-related disorders other treatments. associated with complex behavior change, particularly schizophrenia. The Center for the Treatment and Study of While the boundaries are somewhat blurred, I like to view Anxiety explores new psychotherapeutic approaches to the translational research efforts in our Department in three treat posttraumatic stress disorder and other anxiety disor- categories: 1) basic research; 2) behavioral medicine ders, and the Mood and Anxiety Disorders Program gives research; and 3) clinical research. special attention to drug therapies for mood and anxiety Basic Research – The path from basic investigation to the disorders. The Center for Cognitive Therapy develops bedside is not always straightforward. Basic science inves- treatments for depression and borderline personality disor- tigators may pursue questions without immediate clinical der, the Depression Research Unit conducts studies in bipo- significance, though their efforts may produce findings that lar disorder and depression, and the Center for Psychother- ultimately unlock medical puzzles to improve patient care. apy Research identifies the appropriate therapies for specif- Other basic researchers stick closer to clinical applications, ic disorders. The Center for Mental Healthy Policy and Ser- such as identifying genes that cause or exacerbate disease. vices Research seeks to improve the delivery of care to peo- ple with serious mental illness and the Section on Geriatric The Center for Neurobiology and Behavior is the focal Psychiatry studies the mental disorders that most afflict the point for our basic translational work. Here, scientists elderly. study the neurobiology of disease, working at cellular or molecular levels to understand how the essential building To answer their questions, Department researchers inte- blocks of the neural system develop and change. They grate scientific disciplines and methodologies and tap the search for genes that may predispose individuals to certain expertise of researchers across Penn’s departments and disorders, including mood and anxiety disorders and schools and at other universities and research institutions. schizophrenia. Others seek the genetic basis for human Through formal training programs – such as the highly obesity or examine how anti–depressant, anti-anxiety, and regarded Clinical Research Scholars Program – and infor- anti-psychotic drugs work in the human body. mal mentorship, Department faculty pass on their research expertise to residents and other trainees, transferring to Behavioral Medicine Research – Behavioral medicine exam- future generations the necessary tools to conduct transla- ines the role of behavioral and cognitive factors in the etiol- tional research. ogy, prevention, treatment, and outcomes of major medical illnesses. The Center for Studies of Addiction and the The ultimate goal of this interdisciplinary and interinstitu- Treatment Research Center focus on addictive illness. The tional effort is to translate science into improved clinical Division of Sleep and Chronobiology investigates the basis care. It’s a responsibility our faculty take seriously and, as for sleep disorders, the Weight and Eating Disorders Pro- the results show, fulfill expertly. gram focuses on the prevention and treatment of obesity, the Transdisciplinary Tobacco Use Research Center studies tobacco use and nicotine addiction, and the HIV Preven- Dwight L. Evans, M.D. tion Research Division tests HIV/AIDS prevention inter- Ruth Meltzer Professor and Chair ventions. Professor of Psychiatry, Medicine and Neuroscience In this issue, we pay tribute to Aaron T. Beck, MD, founder and director of the Psychopathology Research Unit, who is

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Program Highlights

UNDERSTANDING AND TREATING THE NATION’S SILENT EPIDEMIC: The Center for Pain Medicine, Research and Policy Begins Its Work f you experience pain on a fre- PENN Behavioral Health. The orthopaedic trauma ward at the Iquent basis, the numbers sug- Center complements the work of University of Vermont. He cared gest that you have company. the Penn Pain Medicine Center in for the same patients in follow-up the Department of • Over 50 million Americans suf- Anesthesiology and fer from chronic pain, one-fifth Critical Care, under the of whom are severely affected. leadership of Lee A. This number is rapidly increas- Fleisher, MD, chair of ing as our population ages, the department. It accruing risk for pain-causing draws upon the expert- disease and injury. ise of clinicians • 80 percent of physician visits throughout the Univer- are tied to complaints about sity of Pennsylvania chronic pain. Health System to care for patients suffering • Over $100 billion is spent annu- from persistent pain ally on medical costs, disability caused by injuries, dis- Director Rollin Gallagher, MD, MPH and payments, worker retraining, eases, and other condi- Clinical Coordinator Maripat Welz-Bosna, MSN, CRNP and lost productivity resulting tions, including cancer. from pain. The ultimate goal of treatment is to at a family practice center, while Pain affects personal relationships, improve quality of life and func- running an NIH-funded training the ability to work productively, to tion. program for primary care physi- enjoy life, to carry out every day cians and psychiatrists in biopsy- The Center for Pain Medicine activities. It has psychological con- chosocial medicine. He recollects became a reality thanks to the sequences – causing fear, anger, that “about half the difficult chron- vision and commitment of two worry, and loss of sleep, and erod- ic disease management problems I grateful patients, who worked ing self-esteem. Pain can exacer- saw at Vermont were patients with with Director Rollin Gallagher, bate medical conditions – reducing intractable pain.” MD, MPH to develop the original the body’s capacity to ward off dis- concept for the Center. They have With a background in family prac- ease, generating side effects from continued to nourish it with gener- tice, medical psychiatry, epidemi- pain-killing medications, and ous financial support and adept ology, and academic medical inducing clinical depression. guidance. administration, he established a The direct cause of acute pain is multi-disciplinary pain program at Dr. Gallagher, Clinical Professor of usually identifiable and remedia- Vermont, featuring an outpatient Psychiatry at Penn, has been criti- ble, but chronic pain presents a dif- clinic and inpatient beds. He cally involved in the development ferent challenge. Often, its under- became attracted to the research of the new specialty of Pain Medi- lying cause cannot be eliminated, and training aspects of Pain Medi- cine, which he characterizes as “a and comprehensive pain manage- cine, and went on to develop pain convergence of neuroscience, psy- ment is needed to relieve suffering. centers and fellowship training chology, and clinical medicine.” programs at SUNY Stony Brook Ministering to patients who suffer His interest in the causes and per- and MCP Hahnemann University, with chronic pain is the primary vasive effects of chronic pain came before coming to Penn and the Vet- mission of the Center for Pain early in his career, when he pro- erans Administration Medical Cen- Medicine, Research and Policy, vided consultation/liaison psychi- ter in 2004. launched in September 2005 by atry services on an inpatient Continued on page 4

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Continued from page 3 Pain is serious, and real, yet it is from 2000 to 2005. the pain medicine specialist for neither well understood nor what is still considered the clinical “The biggest breakthroughs,” says appreciated, even by many physi- art of selectively integrating these Dr. Gallagher, ”have come about cians and health care providers. treatments for each individual because of advances in the disci- Dr. Gallagher explains that the patient with chronic pain.” plines of epidemiology and the major reason for this is “inade- neurosciences. Epidemiologic The Center for Pain Medicine quate education in medical school studies have established that draws upon the newest research and training in residencies, per- chronic pain is not a psychiatric advances in treating patients with petuated until now by the rela- a multi-disciplinary tively few medical approach. It is not tied departments dedi- to any specific therapy cated to the mission The Center for Pain Medicine draws upon or class of therapies, of pain research, the newest research advances in treating and clinical recommen- education, and train- patients with a multi-disciplinary dations are chosen ing. Pain is often the from among traditional poor step child of approach...Treatment regimens are carefully and complementary, one or more depart- tailored to fit the special goals, needs, and non-invasive and inva- ments, and rarely a sive treatments. Treat- priority.” Chronic circumstances of each patient. ment regimens are pain represents a carefully tailored to fit “silent epidemic” in condition, but rather that many the special goals, needs, and cir- America, its victims the “walking different injuries and diseases ini- cumstances of each patient. wounded.” tiate the chronic pain process in The patient’s care is personally Dr. Gallagher has sought to cor- the peripheral and central nervous managed by a pain medicine spe- rect this imbalance at every insti- system, with negative psychologi- cialist who is expert at coordinat- tution he has worked, as well as at cal and social consequences such ing and orchestrating diverse a national level. He has been an as psychiatric morbidity. Specific treatments. Maripat Welz-Bosna, active leader in major national pain conditions are each uniquely MSN, CRNP, the Center’s Clinical pain medicine organizations, affected and complicated by psy- Coordinator and a pain manage- including the American Academy chological and social factors, ment nurse practitioner highly of Pain Medicine (AAPM), the including higher rates of co-occur- experienced in both palliative care American Board of Pain Medicine ring psychiatric disorders than in and pain medicine, plays a key (ABPM), and the National Pain other chronic diseases.” This role in assuring personalized Foundation. Among his many complexity suggests why chronic attention to every patient’s indi- contributions to the field, he is the pain is so little understood, says vidualized treatment program. founding, and current, editor-in- Dr. Gallagher. chief of AAPM’s academic journal, Complementing its clinical focus, But there is cause for optimism. Pain Medicine. the Center is also actively engaged “The rapid development of the at the national and regional levels Heightened attention at the insti- neurosciences, including neu- in educating health care profes- tutional and national levels is roimaging,” says Dr. Gallagher, sionals about how to treat pain, achieving results. Over the last “has increased our understanding conducting pain research, formu- four decades, there has been a of the anatomy, molecular biology, lating and advocating public poli- large increase in the number of and pathophysiology of different cy to improve the access of research publications dedicated to pain disorders, demonstrating the patients to pain treatment and the science of pain, as indicated neuroplastic changes in the spinal health care in general, and pro- by a medline search using the key cord and brain that cause, perpet- moting greater awareness of pain word “nociception” (the activation uate, and worsen pain conditions treatment and research among the of pain) – from 45 in the 1970’s, and diseases. The proliferation of general public and health care 532 in the 1980’s, 1391 in the available treatments for pain has professionals. For example, on 1990’s, to 1708 in the half decade greatly expanded the toolbox of Continued on page 5

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Continued from page 4 June 13, Dr. Gallagher present- ed the public health challenge SEARCHING FOR THE GENETIC CAUSES of chronic pain and the need for better education and more OF OBESITY: research at a Congressional The Behavioral Genetics Laboratory Briefing: “The Epidemic of Pain in the Center for Neurobiology and in America”. (For his testimo- Behavior ny, please access www.national- painfoundation.org and follow the links.) Dr. Gallagher recent- xperts disagree on the precise numbers, but the danger is clear – ly was awarded a grant from Eobesity represents a major public health risk in the United States the Department of Veterans and the world, and the trends are not favorable. Affairs, working with a team Researchers in the Department of Psychia- from Walter Reed Army Med- try are taking on obesity from several ical Center and the University directions. They are playing leadership of Pennsylvania, to study the roles in the School of Medicine’s Institute course and outcomes of soldiers for Diabetes, Obesity and Metabolism, with combat-related limb established in 2005 to support the efforts of injuries. Penn faculty to better understand the seri- “Chronic pain used to be ous disorders cited in its name. Closer to thought of as psychosomatic,” home, the Department’s widely recognized says Dr. Gallagher, “but we can Weight and Eating Disorders Program is now demonstrate the patho- participating in multiple clinical trials physiology of chronic pain in focused on preventing and treating obesity. the central nervous system. We Meanwhile, in the new Translational know much more about how Director R. Arlen Price, PhD Research Laboratories, the Behavioral and where in the CNS emotions Genetics Laboratory (BGL) is seeking to discover the genetic basis for interact with pain disease and human obesity. Established in 1987, the BGL is one of the component ways that treatments – from laboratories of the Center for Neurobiology and Behavior, the focal neurostimulation to pharmaceu- point for the Department’s basic science research programs. ticals to psychotherapy – bring relief.” The Center for Pain Prior research indicates that genes may account for up to two-thirds of Medicine, Research and Policy individual differences in obesity, and Director and Professor of Psy- is playing a continuing role in chology in Psychiatry R. Arlen Price, PhD and his team are trying to advancing and disseminating identify the precise genes that account for these differences. knowledge about pain and Dr. Price acknowledges that the task he and his colleagues face is chal- using the latest research find- lenging. “As with all behaviorally mediated traits,” he explains, “the ings to assist those afflicted inheritance of obesity is complex, involving genes, the environment, with pain’s devastating effects. and their interactions.” Just as no unique diet or product has been To schedule an appointment or found to control weight gain, no single causal factor is likely either. find out more about the Center The work begins with genetic material drawn from members of over for Pain Medicine, please call 500 families who have volunteered to participate in BGL’s studies. This the PENN Behavioral Health unique sample allows BGL researchers to compare the genetic material Contact Center (Mon. – Fri. 8:00 of family members with normal weight to that of their overweight rela- am to 6:00 pm) at 1-866-301- tives. The BGL has also developed a comparison sample of over 500 4PBH, or access the Center for “controls” from a diminishing minority of the population, those who Pain Medicine Website at have never been overweight. http://www.med.upenn.edu/ painmedicine/ O Using specialized areas of expertise, such as molecular epidemiology

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Continued from page 5 and quantitative and molecular genetics, BGL In carrying out these basic science inquiries, Dr. investigators analyze the genetic material to tease Price works with a talented research group. The out meaningful genetic dissimilarities that may complex analyses for the studies on gene interac- account for obesity susceptibility and resistance. tion and imprinting were completed by Research Associate Chuanhui Dong, PhD, who has expertise The BGL is carefully building the scientific plat- in quantitative genetics and molecular epidemiolo- form from which to launch a targeted search for gy. Research Assistant Professor Wei-dong Li, MD, obesity-related genes. In two studies, Dr. Price’s PhD mainly focuses on molecular genetics. Dr. group demonstrated that some gene effects depend Price also collaborates with mathematical geneticist on the presence of Hongyu Zhao, PhD, variation in other parts of Yale University. of the genome. Of par- ticular interest are The BGL is also con- findings that indicate ducting more clinical- effects for genes on ly oriented research. chromosome 20 occur The drug Olanzapine primarily in the pres- is effective in treating ence of variations on schizophrenia and chromosome 10. This bipolar disorder. interaction may be an However, it causes important clue to help significant weight locate genes that influ- gain in many individ- ence obesity. uals. The Laboratory has been working Another hint to solv- with scientists at Eli ing the puzzle may lie Lilly and Perlegen in the BGL’s explo- Sciences to determine rations in the emerg- whether the same ing area of genomic The BGL Research Team: (from left) Sahib Shinde, PhD; Wei-Dong genes that influence imprinting. Studies in Li, MD, PhD; Guang Ming Yuan, BS; Director R. Arlen Price, PhD; obesity account for the this area identify and and Chuanhui Dong, PhD drug-associated investigate those genes weight gain. This which express them- study is one of the selves differently – i.e., first to scan the entire human genome by testing how they act within the body – depending upon more than 1.3 million genetic markers in weight whether they are inherited from the male or female gain-susceptible and resistant individuals. BGL parent. Genomic imprinting is known to affect investigators have replicated several of these gene body size and composition in animals, such as mice effects in their family samples, finding a previously and pigs. BGL researchers recently found three unknown genetic pathway influencing weight gain chromosome regions that have genes with strong and obesity. parental effects, two maternal and one paternal, suggesting that imprinting may be common in The BGL’s work is about establishing relationships humans as well. A BGL paper describing evidence among genes and their impact on human behavior for genomic imprinting effects on human obesity and physiology. Understanding these relationships was published last year (Dong, C, Li, W-D, Geller, has required the BGL to develop bonds of a differ- F, Lei, L, Li, D, Gorlova, OY, Hebebrand, J, Amos, ent sort – collaborations among scientists, bridges CI, Nicholls, RD, Price, RA. Possible genomic between scientific disciplines, and connections imprinting of three human obesity-related genetic between clinically-inspired questions about obesity loci. American Journal of Human Genetics 2005, 76: and basic research at the molecular level. O 427-437).

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Our Distinguished Faculty

AWARDS & HONORS

Departmental Honors Joseph DiGiacomo, MD was the second recipient of the Annual Award for Clinical Faculty. This award, funded by The Albert Stunkard Faculty Recognition Award is given a clinical faculty member, is given to a volunteer clinical annually to faculty members who are outstanding teach- faculty member who has demonstrated long-term loyalty ers and mentors. The graduating resident class selects to the Department and excellence in teaching and/or award winners who have significantly influenced their supervising. education and training. Named for Albert J. Stunkard, MD, Emeritus Professor of Psychiatry and former Chair of Cory F. Newman, PhD was the recipient of the Fifth Penn the Department, this award recognizes Dr. Stunkard’s Psychotherapy Professorship, which entails a special invita- enormous contribution to the education, training, and tion to lecture to the Psychiatry residents on advanced support of Department housestaff. James Stinnett, MD, clinical issues. Dr. Newman presented the lecture in June. Joseph DiGiacomo, MD, Jody Foster, MD, MBA, Alexandra McLean, MD, and John O' Reardon, MD received this honor in 2006. School of Medicine & University Honors Robert M. Weinrieb, MD received a 2006 Penn Pearls The 2006 PGY-3 & 4 Teaching Award was awarded to Clau- Teaching Award. This award is given by the medical stu- dia Baldassano, MD and the 2006 PGY-1 & 2 Teaching dents to honor their best clinical teachers, both faculty Award was awarded to Christos Ballas, MD. These and residents. In addition, he was appointed Director of awards honor those individuals whom the residents con- the Consultation/Liaison Psychiatry Service at HUP. sider the most effective teachers of the academic year and exemplary in shaping their overall education. Regional, National & International Honors Moira Rynn, MD was the 2006 recipient of the Earl Bond Award. Initiated by the efforts of Dr. William Peltz, this Treating and Preventing Adolescent Men- annual award is given to a Department member who has tal Health Disorders, What We Know distinguished himself/herself for teaching at the medical and What We Don’t Know received the student, resident and/or graduate level. 2005 Best Book in Clinical Medicine Award from the Association of American Pub- Christian Kohler, MD was awarded lishers, the principal trade association of the 2006 Martin P. Szuba Award for Excel- the book publishing industry. The vol- lence in Clinical Teaching and Research. ume is edited by Dwight L. Evans, MD, This award is presented annually to a Edna B. Foa, PhD, Raquel E. Gur, MD, PhD, Herbert Department faculty member with out- Hendin, MD, Charles P. O’Brien, MD, PhD, Martin E. P. standing teaching abilities, ongoing Seligman, PhD, and B. Timothy Walsh, MD. The book, clinical research, and a focus on trans- designed for both mental health professionals and the lay lating research concepts into clinically public, is a product of the Adolescent Mental Health Ini- useful teaching, all of which Dr. Szuba embodied in his tiative, supported by the Annenberg Foundation Trust at work. Sunnylands and the Annenberg Public Policy Center at Penn. Oxford University Press is the publisher. Teaching by the residents is an invaluable part of medical student education. The Medical Student Teaching Award is Two Department of Psychiatry faculty were listed in the given to residents who have been consistently outstand- “Top Doctors” issue of Philadelphia Magazine (May 2006): ing in their ability to teach. Juliette Galbraith, MD and Anthony L. Rostain, MD (Child & Adolescent Psychiatry John Mitchell, MD received this award in 2006. ADD/ADHD, autism) and Edward S. Brodkin, MD (autism, learning disorders – social). The Psychodynamic Psychotherapy Award is given annually by the Psychoanalytic Cluster Steering Committee to Aaron T. Beck, MD was the recipient of the 2006 Albert graduating residents in recognition of their excellence in Lasker Clinical Medical Research Award from the Albert and providing psychodynamic psychotherapy. C. Pace Duck- Mary Lasker Foundation – please see this issue’s Cover ett, MD and Geoffrey Neimark, MD received this award Story for more details about this major honor. Dr. Beck in 2006. was also the recipient of the Gustav O. Lienhard Award Continued on page 8

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Continued from page 7 from the Institute of Medicine for outstanding achievement Michael P. Kowitt, PhD was elected Chairman of the Edu- in improving health care services in the cation Committee of the Psychoanalytic Center of Philadel- United States. Dr. Beck also received the phia in 2005. Lifetime Achievement Award from the American Foundation for Suicide Preven- Paul J. Moberg, PhD was elected to the Board of Directors tion for “his 50 years of pioneering of the American Academy of Clinical Neuropsychology. He research into suicide.” Foundation Presi- was also the recipient of the award for Distinguished Contri- dent Dwight L. Evans, MD presented the butions to the Science and Profession of Psychology from the award to Dr. Beck at the AFSP’s 18th Pennsylvania Psychological Association. Annual Lifesavers Dinner in May. Since October 2005, David W. Oslin, MD has been the National Director of the Center of Excellence in Substance Stanley N. Caroff, MD was appointed a member of the Abuse Treatment and Education (CESTATE) of the Depart- Pennsylvania Psychiatric Society Committee on Veterans ment for Veterans Affairs. Affairs and State Hospital Issues in 2006. Robert L. Sadoff, MD received the 2006 Isaac Ray Award Judith A. Coche, PhD was appointed to the Certification from the American Psychiatric Association, the highest Board of the American Group Psychotherapy Association. national award in forensic psychiatry. Isaac Ray, MD was In February 2007, she is scheduled to teach the certification one of the founders of the APA in 1844 and is considered course required for national certification in group psy- the “Father of Forensic Psychiatry” in the United States. chotherapy. David B. Sarwer, PhD was named Chair of the Bariatric In June, Charles Dackis, MD received a Surgery Section of the North American Society for the Research Award from The Caron Founda- Study of Obesity. tion, a non-profit addiction treatment organization. Dr. Dackis was cited as an Jeffrey P. Staab, MD was elected to membership in the individual who has made an “outstanding American Neurotology Society and the international contribution towards the on-going battle Bárány Society for his research on psychiatric and neuroto- against addiction and chemical dependen- logic morbidity in patients with chronic dizziness. cy.” Albert J. Stunkard, MD was awarded a Doctorate of Hon- Joseph DiGiacomo, MD received the Lifetime Achievement oris Causa from Louisiana State University in May. Award from the Philadelphia Psychiatric Society. Dr. DiGia- como was also one of the recipients of the second annual Richard F. Summers, MD was one of the recipients of the Irma Bland Award for Teaching Residents from the American second annual Irma Bland Award for Teaching Residents from Psychiatric Association and its Council on Medical Educa- the American Psychiatric Association and its Council on tion and Lifelong Learning. The award was established to Medical Education and Lifelong Learning. He was also honor Irma Bland, MD in tribute to her unique and creative selected as Chair of the American Psychoanalytic Associa- contributions to psychiatric education. tion's Committee for University and Medical Education.

David F. Dinges, PhD was named Editor- Paul Root Wolpe, PhD will assume the in-Chief of Sleep, the leading journal for role of President of the American Society sleep research and sleep medicine. Sleep is for Bioethics and Humanities (ASBH) in the official publication of the Associated October. The ASBH is the national profes- Professional Sleep Societies, LLC, a joint sional organization for scholars in venture of the American Academy of Sleep bioethics and the medical humanities. It Medicine and the Sleep Research Society. has over 1,600 members, including physi- cians, nurses, social scientists, legal schol- Ruth S. Fischer, MD was elected by The ars, historians, philosophers, and others who study the eth- COPE Committee on Women’s Issues in Psychoanalytic ical, social, legal, and historical issues in medical ethics. Education of the American Psychoanalytic Association to be The National Women’s Scholar for 2007-2008. She will visit George E. Woody, MD and Dr. Edwin several institutions around the country to talk and teach Zvartau received the 2006 National Institute about female psychology and educational issues. on Drug Abuse International Program Award of Excellence in Collaborative Research. Dr. Edna B. Foa, PhD received a Fulbright Senior Specialist Zvartau is the Vice Rector for Science at Award. In June, Dr. Foa worked closely with the faculty of Pavlov State Medical University in St. the School of Social Work at Haifa University, teaching Petersburg, Russia. The award was pre- graduate students and consulting on research projects sented at the June meeting of The College which examine issues related to psychological reactions to on Problems of Drug Dependence. O traumatic experiences and their treatment. www.med.upenn.edu/psych www.med.upenn.edu/psych PAGE 9

NEWS & GOINGS ON

Aaron T. Beck, MD Lasker Award Reception November 6, 2006 James L. Stinnett, MD Portrait Unveiling The School of Medicine is holding a reception to November 9, 2006 honor Dr. Beck, recipient of the 2006 Lasker Clini- cal Medical Research Award, on November 6 at the Union League, 5:00-7:00 pm. All Department fac- Please join us on November 9 at 1:00 pm in ulty and staff are invited to attend. Please contact the BRB II/III Lobby for the unveiling of Dr. Tina Callaghan at (215) 662-2818 for details. Stinnett’s portrait. The portrait unveiling cere- mony and reception will follow Dr. Stinnett’s Grand Rounds lecture in the BRB II/III Audito- rium at 12:00 pm.

Jay D. Amsterdam, MD was selected to serve as for What Purposes?" In April, he gave a lecture in Advisory Board Member and lecturer in the Laurel, Maryland on "Sleep, Fatigue and Stress: "Insight into Depression" Penn CME Lecture Series. Monitoring Human Behavioral Capability" at a col- In addition, he serves as a Fellow and Advisory loquium sponsored by the Johns Hopkins Univer- Board member of Penn’s Center for Spirituality sity Applied Physics Laboratory. and the Mind, which examines the interface between our social and cultural beliefs and neuro- In 2005 and 2006, Edna B. Foa, PhD conducted science. intensive workshops on "Prolonged Exposure Therapy: A Cognitive Behavioral Treatment for Howard Scott Baker, MD gave a talk in October Posttraumatic Stress Disorder" for mental health 2005 in Baltimore at the 28th Annual International professionals for several Veterans Affairs medical Conference on The Psychology of the Self, spon- centers and other sites in the U.S. and abroad, sored by The International Association for Psycho- including Switzerland, Korea, and Israel. In Febru- analytic Self Psychology. The presentation focused ary, she presented "Success and Challenges in Dis- on the relationship between religion and psycho- seminating Evidence-Based Treatment: The Case of analysis, specifically exploring how self psycholo- PTSD" at The Community Stress Prevention Center gy offers a paradigm that can make sense of a in Haifa, Israel. patient’s spiritual experience. This year, Michael P. Kowitt, PhD chaired a panel Stanley N. Caroff, MD delivered a lecture on on relational theories in psychoanalysis at a faculty “Neuroleptic Malignant Syndrome, Catatonia, and symposium at the Psychoanalytic Center of Related Conditions” to the Northeastern Pennsyl- Philadelphia. vania Psychiatric Society in May. Caryn Lerman, PhD delivered In Basel, Switzerland in May, David F. Dinges, the Clinical Research Keynote PhD delivered a Keynote Address at an Interna- Lecture in February at the annual tional Conference of the European Union 6th meeting of the Society for Framework Integrated Project SENSATION. The Research on Nicotine and Tobac- SENSATION project focuses on the technology and co. The lecture was entitled physiology of monitoring sleep and sleepiness. Dr. "Pharmacogenetic Approaches to Dinges spoke on "Fatigue Management Technolo- Nicotine Dependence Treat- gies: What Technologies, Deployed in What Ways, ment.” In July, she presented a

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Continued from page 9 lecture on "The Role of the Endogeneous Opioid ton Biomedical Research Institute in Baton Rouge. System in Nicotine Reward" at Oxford University In June, he spoke before the Society of Bariatric at a meeting of the British Association for Psy- Surgeons in San Francisco. In August, he lectured chopharmacology. on eating disorders at the Eating Disorders Research Society Meeting in Port Douglas, Aus- Marion Lindblad-Goldberg, PhD delivered a Ple- tralia and in September he spoke at the Internation- nary Address on "Our Sacred Models of Relational al Congress on Obesity in Sydney, Australia. Therapy: Relevant or Passé" and conducted a Workshop on "Effective In-Home Therapy" at the Richard F. Summers, MD is Co-Chair of the collab- 63rd Annual Conference of the American Associa- orative effort between Penn and the Psychoanalytic tion for Marriage and Family Therapy in Kansas Center of Philadelphia to develop interdisciplinary City, Kansas in October 2005. In May, she spoke on educational and research programs. "Effective In-Home Therapy" and "A Model of Cou- ples Therapy" at the Wheeler Clinic in Hartford, In March, Elizabeth B. Weller, MD presented Connecticut. Grand Rounds at the Penn State University College of Medicine on "Depression and Its Treatment in Cory F. Newman, PhD presented Children and Adolescents: The SSRI Saga." In a clinical workshop and research August, she gave Grand Rounds at Cooper Hospi- paper on "Cognitive Therapy for tal in New Jersey on "Diagnosis and Treatment of Borderline Personality Disorder" Depression in Children and Adolescents." Dr. at the VI Congreso Latinoameri- Weller presented the Samuel and Audrey Lang cano de Psicoterapias Cognitivas Memorial Lectureship at William Beaumont Hospi- in Buenos Aires, Argentina in tal in Berkley, Michigan on "Phenomenology, Diag- May. Displaying other talents, Dr. nosis, and Medical Treatment of Childhood Bipolar Newman played an all-Chopin Disorder" in September and Grand Rounds at and Beethoven program in Dunlop Auditorium for Reading Hospital in Reading, Pennsylvania on his 11th annual piano recital in July "Evidence-Based Treatment of Depression in Chil- dren and Adolescents." Robert L. Sadoff, MD was named the Albert Biele, MD lecturer for 2006 at Jefferson Medical School. Paul Root Wolpe, PhD authored the first article on bioethics ever published in Cell, “Reasons Scientists David B. Sarwer, PhD gave lec- Avoid Thinking About Ethics” (125: 1023-1025, tures on several topics in the win- 2006), and wrote an editorial in the Philadelphia ter and spring, including the Inquirer on the Terry Schiavo case, "Technology “Behavioral, Pharmacologic, and Alters Dying in America" (April 30). Surgical Treatment of Obesity” (Linden Oaks Hospital, George E. Woody, MD delivered a lecture, "Treat- Naperville, Illinois), the “Psycho- ment Approaches for Opioid and Alcohol Depen- logical Aspects of Bariatric dence: Medication Development and Emerging Surgery and Body Contouring Interest from the Pharmaceutical Industry," at the after Massive Weight Loss” (ASPS/PSEF/ASAPS annual meeting of the American College of Physi- Body Contouring after Massive Weight Loss Sym- cians in Philadelphia in April. In June, Dr. Woody posium, Dallas, Texas), the “Management of Late presented at the annual meeting of The College on Diabetes” and “Managing Patients with Difficult- Problems of Drug Dependence on "HIV Risk to-Treat Hypertension” (Diabetes Xchange: Effec- Reduction Through Treatment: An Overview of tively Managing the Metabolic Syndrome, Founda- Experience with Opioid Agonist Therapies in Rus- tion for Better Health Care, Philadelphia). sia and Former Soviet States" and "Emergency Department Visits Involving Buprenorphine Abuse: Albert J. Stunkard, MD delivered lectures at the 2003-2005." He also co-chaired a session on Karolinska Institute in Stockholm and the Penning- "Progress in Buprenorphine Treatment." O

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RESEARCH NEWS

The News Is In -- Psychiatry Again Ranked #2! or the sixth straight year, the Department of Psychiatry is ranked #2 among Fall psychiatry departments nationwide in its level of funding from the National Institutes of Health. For FY2005 (the most recent year for which data are available), faculty in the Department received $52.2 million in total NIH funding, second only to the University of Pittsburgh and ahead of the psychiatry depart- ments at Yale, Duke, and the University of California, San Diego. While NIH ranking is only one indicator of the quality of the Department’s investigative studies, the peer-review process which govens all NIH awards ensures that sci- entific quality is the major criterion for successful applications. The Department’s elite standing among its peers speaks volumes about the depth and breadth of the scientific expertise of our faculty and staff.

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Continued from page 11 Jay D. Amsterdam, MD has launched new research Ellen W. Freeman, PhD published an article in the initiatives in the field of Complementary and Alter- Archives of General Psychiatry in April entitled, "Asso- native Medicine for mood and anxiety disorders. ciations of Hormones and Menopausal Status with He will study the use of Chamomile to treat Gener- Depressed Mood in Women with No History of alized Anxiety Disorder and Black Cohosh to treat Depression” (Freeman EW, Sammel MD, Lin H, Nel- menopause-related anxiety symptoms. Dr. Amster- son DB. 2006; 63:375-382). dam has also begun a new research project to explore dopamine transporter binding affinity using Paul J. Moberg, PhD received an SPECT brain imaging in patients with depression, Independent Investigator Award and how these brain images may visually portray grant from the National Alliance the impact of psychotherapy and pharmacotherapy for Research on Schizophrenia and in treating depression. Finally, Dr. Amsterdam has Depression entitled, “Olfactory recently been involved in the development of the Dysfunction in Schizophrenia: A first transdermal antidepressant patch, and has Model System to Investigate Aber- authored the leading publications on the initial piv- rant Neurodevelopment.” otal trials with this drug. Richard J. Ross, MD, PhD, and Joan M. Cook, Edward S. Brodkin, MD helped PhD, have continued work on a grant funded by the organize the March 2006 Department of Veterans Affairs pertaining to the Penn/CHOP research retreat enti- treatment of sleep and nightmare disturbances in tled, “Research Perspectives in Vietnam combat veterans with posttraumatic stress Autism.” He delivered a lecture at disorder. the retreat on “A Mouse Model System for Genetic Analysis of David B. Sarwer, PhD was the lead editor on Sarw- Sociability, An Autism Endophe- er DB, Pruzinsky T, Cash TF, Goldwyn RM, Persing notype.” Dr. Brodkin also helped JA, Whitaker LA (eds.), The Psychology of Reconstruc- organize a Penn session in March on “High Func- tive and Cosmetic Plastic Surgery: Clinical, Empirical, tioning Autism and Asperger Syndrome: Promoting and Ethical Perspectives, Lippincott, Williams, & Successful Outcomes Across the Life Cycle.” Wilkins, 2006. Dr. Sarwer, Thomas A. Wadden, PhD, and Noel Williams, MD (Department of Surgery) Stanley N. Caroff, MD is the Site Director for an were co-editors for a supplemental issue of the jour- National Institute of Mental Health-funded Schizo- nal Obesity. In addition, Dr. Sarwer received a grant phrenia Trials Network study to examine the effec- from the American Society of Plastic Surgeons to tiveness of switching antipsychotic medications. He continue his study entitled, “Psychological Status is also Site Director for a Department of Veterans Following Cosmetic Breast Augmentation.” Affairs Cooperative Studies Program investigation of the use of long-acting injectable risperidone to A paper by Albert J. Stunkard, treat schizophrenia. MD has recently been accepted for publication in the Journal of Clinical Edna B. Foa, PhD and her team have received a Psychiatry . The paper, “A Para- three-year grant from the National Institute on Alco- digm for Facilitating Pharma- hol Abuse and Alcoholism to continue their study cotherapy at a Distance: Treatment "Naltrexone and CBT (Cognitive Behavioral Thera- of the Night Eating Syndrome,” py) in Patients with Alcoholism & Posttraumatic describes a novel method of psy- Stress Disorder." Investigators are exploring treat- chopharmacology. ments for patients suffering from both alcohol dependence and PTSD. The project evaluates the Richard F. Summers, MD was the Templeton Foun- relative efficacy of naltrexone, prolonged exposure dation Senior Fellow at the Positive Psychology therapy, and their combination in treating symptoms Center in May and June, 2006, studying the integra- of both disorders. tion of psychodynamic psychotherapy theory and technique with principles of positive psychology. O Continued on page 13

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Continued from page 12 At the Treatment Research Center ...

altrexone, discovered by the Addictions Research Center at the Philadelphia VA in the 1980s Nas a new treatment for alcoholism, was approved by the FDA in depot (injectable) form (Viv- itrol®). In June, the drug went on sale in a depot form that will prevent relapse for 30 days after a single injection. This new treatment is expected to have a major impact on the treatment of alco- holism. Related to this, Charles P. O’Brien, MD, PhD received a Dana Foundation Grant to coor- dinate a national study of depot naltrexone to prevent relapse in probationers and parolees with a history of heroin addiction. Investigators at the TRC are playing leading roles in clinical trials designed to appraise the effects of specific drugs on cocaine and alcohol dependence. Kyle M. Kampman, MD, Charles Dackis, MD, Kevin G. Lynch, PhD, Helen Pettinati, PhD, Carlos F. Tirado, MD, Peter W. Gariti, PhD, Thorne Sparkman, MD, Michal Atzram, and Charles P. O’Brien, MD, PhD participated in a trial to evaluate the efficacy of amantadine, propranolol, and their combination in cocaine dependent patients with severe cocaine with- drawal symptoms. Under the direction of Dr. Pettinati, the TRC participated in the COMBINE trial, the largest government-sponsored pharmacotherapy study of alcohol dependence done to-date. The results demonstrate that naltrexone treatments with structured medical management or in combination with specialized alcohol counseling by a behavioral specialist are equally effec- tive in treating alcohol dependence. This finding was published in the Journal of the American Medical Association [Anton RF, O'Malley SS, Ciraulo DA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, Locastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift RM, Weiss RD, Williams LD, Zweben A: Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence. The COMBINE study: a randomized controlled trial. JAMA 2006;295(17):2003-17]. Also under Dr. Pettinati’s direction, TRC investigators conducted a pilot trial of the atypical antipsychotic medication, quetiapine (trade name Seroquel®), for the treatment of alcohol dependence. The results demonstrate that quetiapine significantly increased the rate of com- plete abstinence as compared with placebo treatment. Findings have been presented at the annual meeting of the American Psychiatric Association in May 2006, and also at the annual New Clinical Drug Evaluation Unit Meeting in June 2006. In addition, under the direction of David W. Oslin, MD, the Philadelphia Veterans Affairs Med- ical Center developed a telephone-based systematic assessment service called the Behavioral Health Lab (BHL). The utility of this system was assessed, and the results were published [Oslin DW, Ross J, Sayers SL, Murphy J, Kane V, Katz IR. Screening, assessment, and management of depression in VA primary care clinics: The Behavioral Health Laboratory. J Gen Intern Med 21:46- 50, 2006]. The introduction of the BHL into primary care resulted in the identification of mental health and substance misuse problems in more patients. Dr. Dackis and David S. Metzger, PhD are starting a new study entitled, “Community-based Modafinil Treatment of Women with Cocaine Dependence and HIV High-Risk Behavior.” O

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RESEARCH GRANTS

The following sponsored research funding was received by the Department during the period January 1, 2006 through August 31, 2006.

New NIH Awards (includes New and Competing Renewals)

Name Sponsor Project Title Arnold, Steven NIH / Rush-Presbyterian-St. Neurobiologic Study of Psychological Distress and Dementia Luke’s Medical Center Crits-Christoph, Paul F. NIH Patient Feedback Effectiveness Study Crits-Christoph, Paul F. NIH Psychotherapy for Major Depression in the Community Foa, Edna NIH Naltrexone and CBT for Patients with Alcoholism and PTSD Foa, Edna NIH Treating Adolescents with CSA-related PTSD Gur, Ruben NIH The Neurobiology of Affective Dysfunction in Schizophrenia Lucki, Irwin NIH Training Program in Neuropsychopharmacology Sarwer, David NIH / Drexel University Prevention of Obesity at Universities: A Randomized Trial Schnoll, Robert A. NIH Smoking Cessation for Head and Neck Cancer Patients Wadden, Thomas A. NIH Look Ahead: Action for Health in Diabetes Wadden, Thomas A. NIH / Temple University The Safety and Efficacy of Low and High Carbohydrate Diets Woody, George E. NIH / UCLA Delaware Valley Node of the National Drug Abuse Clinical Trials Network -- Protocol 0027 Start Zubritsky, Cynthia NIH / Indiana University Simulation Model for Mental Health Systems Planning

Other Federal Agencies

Name Sponsor Project Title Brennan, Francis Department of Veterans Biomedical Markers and Treatment for Impaired Avoidance Learning in Affairs FMR1 KO Mice Caroff, Stanley N. Department of Veterans Long-Acting Injectable Risperidone in the Treatment of Schizophrenia Affairs Dinges, David F. National Space Minicog: A Portable and Fast Assessment of Cognitive Functions Biomedical Research Dinges, David F. DHHS / Washington State Individualized Biomathematical Modeling of Fatigue and Performance University Ehrman, Ronald Department of Veterans Integrating Practice Guidelines for Smoking Cessation into Mental Health Affairs Care for PTSD Oslin, David Department of Veterans Improving Behavioral Health Care: Implementation of the BHL-SP Affairs Ross, Richard Department of Veterans Randomized Controlled Psychotherapy Trial for Combat-Related Night- Affairs mares in Vietnam Veterans with PTSD

Other Agencies and Organizations

Name Sponsor Project Title Bechtholt, Anita National Alliance for Research on Examining the Mechanisms of Chronic Antidepressant Efficacy Schizophrenia and Depression

Li, Wei-Dong American Heart Association Genetics of Lipid Related Phenotypes in Obesity Cohorts

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Other Agencies and Organizations (continued)

Name Sponsor Project Title Lohoff, Falk W. American Psychiatric Association Bipolar Disorder

Lohoff, Falk W. American Philosophical Society Genetics of Schizophrenia and Bipolar Disorder

Lohoff, Falk W. National Alliance for Research on Shared Bipolar/Schizophrenia Susceptibility Genes on Chromosome Schizophrenia and Depression 8P Rodriguez, Daniel Cancer Research and Prevention Mediators of the Adolescent Physical Activity and Smoking Relation- ship

Sarwer, David Plastic Surgery Educational Psychological Status Following Cosmetic Breast Augmentation

Schnoll, Robert A. American Cancer Society Comparing the Lozenge to the Patch for Smoking Cessation

Stunkard, Albert J. Robert Wood Johnson Foundation Statistician Support for Childhood Obesity Studies

Wadden, Thomas A. William Wrigley Jr., Company Use of Chewing Gum to Facilitate Appetite Control and Weight Loss in Overweight Individuals Treated by Lifestyle Modification Wadden, Thomas A. Commonwealth of Pennsylvania / Primary Care Network for the Treatment of Adolescent Obesity CHOP

Wenzel, Amy National Alliance for Research on Cognitive and Behavioral Predictors of Suicide Behavior in Suicide Schizophrenia and Depression Attempters

Clinical Trials

Name Sponsor Project Title Amsterdam, Jay D. Eli Lilly and Company A Functional Change and Efficacy of Duloxetine in Patients with Co-Morbid Major Depression Soft Tissue Discomfort Amsterdam, Jay D. Sanofi-Synthelabo, Inc. A Multi-Center Randomized, 30-52 Week Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Saredutant 100 mg Once Daily in the Prevention of Relapse of Depressive Symptoms in Outpa- tients with Major Depressive Disorder Who Achieved an Initial Response to 12 Weeks of Open-Label Treatment with Saredutant 100 mg Once Daily

Langleben, Daniel D. No Lie MRI CLTR: Detection of Deception and Concealed Information with Functional MRI Lucki, Irwin Predix Pharmaceuticals Evaluation of PRX-00023 in Rodent Antidepressant Tests O’Reardon, John P. Cyberonics, Inc. Randomized Comparison of Outcomes in Patients with Treatment-Resistant Depression Who Receive VNS Therapy Administered at Different Amounts of Electrical Charge O’Reardon, John P. Neuronetics, Inc. A Compassionate Use Treatment Protocol for Patients with Major Depres- sion Previously Responsive to RTMS Treatment with the Neuronetics Model 2100 CRS Repetitive Transcranial Magnetic Stimulation System Pettinati, Helen AstraZeneca LP A Multi-Center, Randomized Parallel-Group, Double-Blind Phase IV Com- parison of the Efficacy and Safety of Quetiapine Fumarate to Placebo as Adjunct Therapy

Pettinati, Helen Forest Laboratories, Inc. Initiating Acamprostate Within Versus Post-Detoxification in the Rehabilita- tive Treatment for Alcohol Dependence Siegel, Steven Nupathe, Inc. Development of Implantable Formulations for CNS Applications

Weintraub, Daniel Myriad Pharmaceuticals, Inc. Phase 3 Multicenter, Randomized, Double-Blind, Placebo Controlled Study of the Effect of Daily Treatment with MPC-7869 on Measures of Cognition, Activities of Daily Living and Global Function in Subjects with Mild Demen- tia of the Alzheimer’s Type

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FACULTY IN THE NEWS

In December 2005, Judith A. Coche, PhD Magazine), “New you? New us” (Los Angeles appeared on NBC’s Today to discuss “why Times), and “Sultan of Skin” (Riverfront Times – gift-giving is so hard.” St. Louis, Missouri).

Associated Press medical writer Ms. Lauran Albert J. Stunkard, MD was interviewed by Neergaard interviewed Charles Dackis, MD Ms. Lynne Lamberg for an article on Night Eat- for an article in April about the efficacy of ing Syndrome for Psychiatric News. Modafinil for the treatment of cocaine depend- ence. The piece was widely syndicated. Richard F. Summers, MD was interviewed for an article on dreams, which appeared in the David F. Dinges, PhD was interviewed about May 6 issue of U.S. News & World Report. sleep-related issues for stories appearing in Time Magazine, Forbes, PENN Medicine, and The Daniel Weintraub, MD inter- Baltimore Sun, as well as for an Associated Press viewed for the Paula Zahn article. In May, he contributed to two CNN Show on CNN, along with shows on sleep - "America is Sleep-Deprived: Matthew Stern, MD (Depart- Long-Term Health Consequences Related to ment of Neurology). The seg- Lack of Sleep; Car Accidents Caused by Lack of ment, which aired on March Sleep" and a primetime sleep special entitled 22, was about impulse control "Sleep." disorders in Parkinson's dis- ease and their possible associ- Marion Lindblad-Goldberg, ation with dopamine agonist treatment. Drs. PhD was interviewed for an Weintraub and Stern and colleagues published article on "Adolescents and a paper on their work in this area in the Divorce" which appeared on Archives of Neurology on July 10, 2006, "Associa- the MSN.com Website, on tion of dopamine agonist use with impulse con- "Mothers and Children Partic- trol disorders in Parkinson's disease." (63: 969- ipating in the Same Activities" 973, 2006). in Time Magazine (March), and on "Three Generation Vacations" in Parenting Paul Root Wolpe, PhD was interviewed on Magazine (August). She was also quoted on CBS News by Elizabeth Kaledin in April about single parenting issues in a book by Ellie Slott emerging issues in neuroethics, appeared on Fisher, Mom, There's a Man in the Kitchen and ABC's show Top Priority in May to discuss egg He's Wearing Your Robe (De Capo Press, 2005). donation, and was on National Public Radio's Talk of the Nation in June (with Daniel D. Lan- David B. Sarwer, PhD was interviewed for sto- gleben, MD) describing the science and ethics ries across a spectrum of topics. These includ- of neuroimaging for lie detection. Dr. Wolpe ed: “Can We Ward Off Aging?” (PENN was also quoted extensively in Nature on brain Medicine), “Face Transplantation” (Radio imaging for lie detection (441: 918-919, 22 June Times—WHYY), “Surgically Slim: A Cure for 2006) and in The Scotsman's Sunday Magazine Obesity and Why It’s Risky” (Consumer in “'Bionic Man' Uses Power of Thought to Reports), “10 Shocking Truths about Plastic Control TV” (July 13). O Surgery” (Cosmopolitan), “Saving Face” (Self

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Cornerstones Recognizing the significant achievements of our faculty and staff

ne thing I am known for,” pus. He earned a BA at the Uni- position at the Food and Drug “Osays Paul F. Crits- versity of Pennsylvania, majoring Administration. But when Dr. Christoph, PhD, “is being the in biology with a particular inter- Luborsky offered him a full-time father of 12-year old triplets– two est in environmental biology. A research assistant position, Dr. boys and a girl.” A lesser known skilled athlete, he played baseball Crits-Christoph accepted. As mat- fact is that he and his wife Kather- and basketball on Penn’s fresh- ters turned out, he had chosen his ine, also a clini- road. cal psychologist, During the next and the entire two years, he family are FACULTY SPOTLIGHT worked for expertly trained Dr. Luborsky, and avid scuba and took psy- divers, and eagerly Paul F. Crits-Christoph, PhD chology look forward to courses at exploring the myster- Penn. He then went on to gradu- ies that lie just below the surface. ate school, earning an MS, MPhil, It’s an apt avocation for Dr. Crits- and PhD in Clinical Psychology at Christoph, whose professional Yale University. career is founded on proficient With his post-graduate degrees in training, solid teamwork, and hand, at least one decision seemed boundless curiosity about the clear. “I was always more interest- secrets of the mind. ed in an academic path,” says Dr. Dr. Crits-Christoph, Professor of Crits-Christoph. “The scientific Psychology in Psychiatry, is the questions were what interested Director of the Department of Psy- me. I had considerable training in chiatry’s world-renowned Center statistics and methodology, so for Psychotherapy Research. For man teams, at a time when the Ivy aspects of the process of doing over 20 years, the former Presi- League did not allow freshmen to research, not just the content, were dent of the Society for Psychother- play varsity. also of interest to me.” apy Research and widely pub- As part of his financial aid pack- Coming out of graduate school in lished scholar has pursued two age at Penn, he was randomly 1984, he applied for positions in intriguing lines of inquiry. assigned as a freshman to a work- psychology departments, but “What continues to fascinate me,” study position with Psychiatry again accepted a position with Dr. remarks Dr. Crits-Christoph, “is Professor Lester Luborsky, PhD, a Luborsky who had a grant to hire that while psychotherapy is wide- celebrated psychotherapy a junior faculty member. He took ly practiced, we know little about researcher. To borrow a line from the faculty position at Penn, how it works. Additionally, there Robert Frost’s “The Road Not because Dr. Luborsky’s prime are multiple forms of psychothera- Taken”, Dr. Crits-Christoph’s rela- interest was in psychotherapy py, and we need to figure out tionship with Dr. Luborsky “has research, and he had an active and what works best for what kinds of made all the difference.” He successful research program. patients.” worked for Dr. Luborsky for all Moreover, Dr. Crits-Christoph four of his undergraduate years. emphasizes, “we had successfully For Dr. Crits-Christoph, the path Upon graduation, he first sought collaborated on quite a few papers to these questions has largely jobs in biology, and was offered a up to that point, so I knew it wound through Penn’s leafy cam- Continued on page 18

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Continued from page 17 would be a productive environ- PhD psychology graduate stu- results of a multicenter study of ment.” dents. the treatment of cocaine depend- ence. “The majority of studies of Penn was, indeed, an ideal place The Center’s research agenda has active forms of different psy- to do psychotherapy research. been equally broad and deep, chotherapies find no differences There were two well known and comparing the effectiveness of between the different treatments,” successful programs –- one on various psychotherapies – and says Dr. Crits-Christoph. “In our psychodynamic therapy with Dr. pharmacotherapy – for different cocaine treatment study, we Luborsky, and one with hypothesized that doctor- the Department’s Aaron T. al-level professional psy- Beck, MD, who developed chotherapists, using tech- the theory and practice of Determining the best psychotherapies to treat niques developed specifi- cognitive therapy. Like particular disorders is not easy, but the solu- cally for cocaine depend- most more recently ence, would have better trained clinical psycholo- tions, Dr. Crits-Christoph underscores, will outcomes than individual gists, Dr. Crits-Christoph have “very real and direct implications for and group drug counseling had been exposed to a public health and the lives of many people. “ practiced by addictions variety of clinical counselors.” But the data approaches and was inter- indicated that, contrary to ested in comparing and expectations, “the package of indi- potentially integrating them. maladies, such as cocaine depend- vidual and group drug counseling ence, generalized anxiety disorder By the late 1980’s, the time was was significantly better than pro- (GAD), panic disorder, and right for Dr. Crits-Christoph to fessional psychotherapy, plus depression. assume a leadership role in this group drug counseling.” effort. Dr. Crits-Christoph saw the “Penn has been a great place to When the NIMH ended its Clini- opportunity to expand the scope work in terms of colleagues, the cal Research Center program a of psychotherapy research at Penn quality of the research programs, few years ago, Dr. Crits-Christoph with support from the National and access to patients for research and his colleagues turned to the Institute of Mental Health studies,” says Dr. Crits-Christoph. NIMH’s new program encourag- (NIMH). In 1990, with Dr. Beck’s Departmental collaborations have ing studies in community settings. and Dr. Luborsky’s approval and been developed with George E. For the past few years, the Center collaboration, Dr. Crits-Christoph Woody, MD on substance abuse, has been making the transition to received an NIMH Center grant with Karl Rickels, MD on a study community-based research, and on comparative psychotherapy of combining medication and cog- has recently received an NIMH research, including both cognitive nitive behavioral therapy for grant to partner with a communi- and psychodynamic approaches. GAD, and with Trevor R. Hadley, ty mental health center in It was the only NIMH Clinical PhD on new initiatives in commu- Philadelphia (Northwestern Research Center in the U.S. nity-based research. Collabora- Human Services of Philadelphia). focused solely on psychotherapy tions continue with Dr. Beck to This work represents a major research. At the time, Dr. Crits- explore the use of cognitive thera- future direction for the Center, Christoph, only 36, was probably py for suicidal patients. Dr. Crits- providing the opportunity to test the youngest director of an NIMH Christoph has also been collabo- and disseminate evidence-based Clinical Research Center. rating with Andrew B. Newberg, psychotherapies in routine clinical MD in the Department of Radiolo- Over the past 16 years, the Center settings. gy on brain imaging of patients for Psychotherapy Research has before and after psychotherapy. Determining the best psychothera- furthered its international reputa- (Dr. Newberg has a secondary pies to treat particular disorders is tion, both for teaching and appointment in the Department of not easy, but the solutions, Dr. research. Dr. Crits-Christoph and Psychiatry.) Crits-Christoph underscores, will other faculty at the Center teach have “very real and direct implica- Penn medical students, residents, Investigators at the Center have tions for public health and the post-doctoral fellows, and Univer- produced many research findings, lives of many people. “ O sity undergraduates, and mentor perhaps none as surprising as the

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ix weeks a year, Joseph DiGia- trained in Psychiatry, including At Penn, Dr. DiGiacomo took full Scomo, MD leaves his teaching psychoanalysis, at Tulane Univer- advantage of the opportunity to and clinical responsibilities to sail sity, developing the first of his practice and teach in multiple set- the warm waters of the Gulf of career interests – psychosomatic tings and to see a wide spectrum Mexico off Naples and Key West, medicine. Tulane encouraged him of patients. Taking Dr. Stunkard’s Florida. His “mini-sabbatical” to establish an institute in the field advice, he opened a private prac- allows him time to rejuvenate and but, before he could get started, tice, which he still maintains, to keep current with better under- the latest medical stand the full literature. dimensions of the field. An experienced OLUNTARY ACULTY ROFILE V F P He also sailor, he and his practiced wife, Madonna, institu- tack into the wind tional or run with it, maneuver- Joseph DiGiacomo, MD medicine, ing to take advantage of seeing wind shifts and avoid shoals patients and teaching at the Hos- threatening to interrupt their voy- pital of the University of Pennsyl- age. Much as he navigates his vania, the Institute of Pennsylva- nautical journeys, Dr. DiGiacomo nia Hospital, the U.S. Naval Hos- has steered his career in medicine pital, Harrisburg State Hospital, with a sense of adventure, and Trenton State Hospital, Allentown with consummate skill. State Hospital, and Wernersville Dr. DiGiacomo, Clinical Professor State Hospital. His monthly con- of Psychiatry, has been at Penn for ferences and grand rounds at the 39 years, but his trip did not begin state hospitals brought him into here, nor even with psychiatry for close contact with the seriously that matter. He received his mentally ill, and he developed an undergraduate and medical interest in treating patients suffer- degrees from Wayne State Univer- ing from chronic schizophrenia. sity before an internship in medi- From 1970 to 1980, Dr. DiGiacomo cine at the Detroit Receiving Hos- served as Chief of Psychiatry at pital. This was followed by a resi- Albert Stunkard, MD, then Chair- the Veterans Administration Med- dency and fellowship in Medicine man of Penn’s Department of Psy- ical Center, Philadelphia, where he at Mt. Sinai Hospital in New York. chiatry, invited him to Philadel- developed a comprehensive pro- He then served as an internist in phia. gram in general hospital psychia- the U.S. Air Force from 1959 to That visit proved to be a course- try, including an inpatient psychi- 1962 at MacDill Strategic Air Base changing event. Dr. DiGiacomo atric unit, consultation-liaison in Tampa, returning to Mt. Sinai as vividly remembers that he was service, alcohol treatment unit, chief resident in Cardiology. “blown away” by the “incredible” drug dependence treatment center, While in the Air Force, he was quality of the faculty and resi- and emergency psychiatric serv- impressed with a psychiatrist see- dents, and the possibility to care ice. His contributions at the VA ing patients on the floor. “I real- for ward patients afflicted with helped earn him tenure at Penn. ized that there was more to medi- both medical and psychiatric ail- Second-year psychiatric residents cine than what I was doing,” says ments. Responding to the Chair- and medical sudents now rotate Dr. DiGiacomo, and he altered his man’s suggestion that he stay through the VA program. career direction. awhile, Dr. DiGiacomo recalls During his time at the VA, Dr. thinking that he was “not leaving From 1964 to 1967, Dr. DiGiacomo DiGiacomo developed a new until they kick me out.” Continued on page 20

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Continued from page 19 interest in forensic psychiatry, a I don’t believe in a case, I’ll say Psychiatric Residents’ Excellence natural fit with his data-driven it.” in Teaching Award. In 2006 he and evidence-based approach to received the second annual Irma Dr. DiGiacomo’s career has bene- medicine. He was frequently Bland Award for Teaching Resi- fited from the timely intercession engaged as an expert witness in dents from the American Psychi- of valued mentors who have criminal trials for either the prose- atric Association, the Clinical Fac- cution or defense. Perhaps ulty Award from the his most publicly visible Department of Psychia- testimony was given in try, the Lifetime defense of Edward J. Leary, Achievement Award accused and ultimately con- When Dr. DiGiacomo reflects on his Penn from the Philadelphia victed of detonating a fire- Psychiatric Society, and bomb on a Manhattan sub- years, one thought stands out. “I can’t was again named as way car, which injured 48 believe it’s true,” he says. “I could not have one of American’s Top people. Dr. DiGiacomo tes- Psychiatrists. tified that a combination of asked for anything more.” Dr. DiGiacomo’s vessel prescription drugs taken by has sailed to many Mr. Leary contributed to his intellectual destinations “descent into madness.” during his distin- The case stirred strong guished career, but emotions in New York. After directed him into exciting new there is no doubt that his home appearing at trial one day, Dr. waters. It is entirely fitting that port is here at Penn. Initially ven- DiGiacomo, at a local tavern with one of his great loves is helping turing out as an “insecure” psy- the defense attorney, overheard a future generations of physicians chiatrist, clothed in a white coat patron say, “someone should to sail their own uncharted seas. and bearing a stethoscope, Dr. blow his house up.” The individ- “When I teach residents, I lose DiGiacomo’s interactions with his ual referred to was not the defen- track of my age.” He praises colleagues at Penn have helped dant, but the psychiatrist speak- Chairman Dwight L. Evans, MD him to explore new subspecialties ing in his defense. Fortunately, for revitalizing the Department’s in psychiatry. Penn, he says, “is Dr. DiGiacomo was an anony- residency program and raising the an eclectic place where one can mous presence at the scene. quality of the matriculants to a sample the hors d’oeuvres while high level. And Penn’s medical deciding on the main course.” The Leary case was an important students, he adds, “are very turning point. While Dr. DiGiaco- Learning remains his constant joy. bright, the epitome of idealism.” mo still believes that Mr. Leary’s It is little wonder that retirement actions were influenced by drug Dr. DiGiacomo is an active and is not a concept that Dr. DiGiaco- interactions, and that each defen- enthusiastic participant in the mo embraces. Looking to the dant is entitled to a robust medical student curriculum and horizon, he says he would like to defense, he recognized his own housestaff training. He has been continue to do “more of the personal responsibility “to be part highly honored for his teaching same,” a blend of teaching, lectur- of civilization and to do the right contributions, clinical expertise, ing, consulting, seeing patients, thing.” and his life-long contributions to and discovering. He prefers to psychiatry. He is the recipient of look ahead, but when he steals a Dr. DiGiacomo now limits his the Earl Bond Award from the glance sternward, and reflects on work primarily to civil cases, such Department for teaching medical his Penn years, one thought as malpractice work. Most of his students, residents, and/or gradu- stands out. “I can’t believe it’s legal work is for the defense, but ate students; the Dean’s Award true,” he says. “I could not have whether working for the plaintiff for Excellence in Teaching from asked for anything more.” O or defense, he emphasizes that “if the School of Medicine; and the

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he Department has been recalls. “To this day, people ment, and malpractice cover- Tbuilding its clinical pro- still talk about that party. It age. Bobbie also oversees grams at an increasingly truly felt like the Department provider relations and net- rapid clip, and Bobbie Pugh was family.” work operations for PBH is right at Corporate Ser- the heart of vices, working this effort. hard to foster Bobbie strong relation- does the EMPLOYEE SNAPSHOT ships with the essential – growing and often number of unrecog- Bobbie Pugh network nized – work providers. that helps practi- tioners navigate Bobbie inter- the complex and confusing acts with people and con- world of regulatory require- fronts deadline pressures on ments. a daily basis. “I have learned,” she says, “not to Bobbie has been at Penn for take things personally. Dur- 17 years. She held several ing the course of the day, I positions prior to coming to literally communicate with the Department, most many diverse personalities. notably as Assistant to sever- Maintaining a professional al Associate Deans in the and calm demeanor enables School of Arts and Sciences. me to see the bigger picture – She also found time to enroll getting the job done! in the Wharton management degree program, before mov- It’s not all work, however, ing to the Department of and in her non-Penn time, Psychiatry in September 1996 Bobbie enjoys being with her as Assistant to Rosellen eleven-year-old daughter, Taraborrelli, the Depart- Over time, Bobbie assumed reading, gardening, and ment’s Chief Financial and increasing responsibilities in “catching a good sale!” Bob- Administrative Officer. the Department. Today, she is bie is also a budding entre- the Manager of Provider preneur. She manages Bob- At the very start, Bobbie Relations for the Department bie’s Basics, created in 1999, faced a big challenge. She and PENN Behavioral through which she teaches was given responsibility for Health Corporate Services. basic corporate and office planning and coordinating The office provides critical skills, offers typing services, the departmental staff holi- support services to faculty, as and assists small businesses day dinner at Dave and well as to providers in the with administrative paper- Buster’s, only three months PBH specialty network who work. She is also a Notary away. Bobbie says that “I deliver care to enrollees in Public. didn’t think that I could do PBH’s various service pro- it, but it went off without a grams. The office helps With all this going on, Bob- hitch.” The 1996 party is now providers complete neces- bie is still smiling, and con- regarded as legendary. “It sary paperwork related to tinually keeps things moving was phenomenal,” Bobbie credentialing, billing enroll- as she does. O

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Educational Highlights

INTRODUCING THE RESIDENT CLASS OF 2010

he Department of Psychiatry welcomes the Class of 2010 to the residency-training program. TThe current class of interns in psychiatry was chosen from 499 applicants of whom 89 were ranked. These 10 individuals are extremely talented young doctors who were at the top of their medical school classes and demonstrated a strong commitment to the field, as well as great leader- ship potential. They have shown themselves to be very fine house officers, eager to learn and dedi- cated to providing outstanding clinical care to their patients. This year’s recruitment efforts will begin on November 10th and continue until January 24, 2007. O

Sibel Algon, MD Joshua Blume, MD Scott Campbell, MD Julie Chilton, MD UMDNJ-Piscataway Jefferson University University of Pennsylvania UCSF

Amy Huberman, MD Margot O’Donnell, MD Matthew Prowler, MD Theodore Satterthwaite, MD Johns Hopkins Jefferson University Jefferson University Washington University

Lilly Sehgal, MD Alexander Threlfall, MD New York University Texas Tech University

Additional and updated information about the Residency Training Program can be found on the Residency Program web site -- www.med.upenn.edu/psychres

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RESIDENT ACTIVITIES

From the Chief Resident for the Affiliated Sites --Dhwani Shah, MD he Psychiatry residents have been active in improving our program in a variety of ways. TRyan Connolly,MD, MS, Ben Pumphrey, MD, and Jenny Kim, MD, PharmD have restarted Journal Club with a focus on a critical review of evidence-based literature. A new elective has been implemented to allow PGY-2 residents to focus on specialized aspects of psychiatric treatment, such as pain medicine, sleep medicine, or inpatient child and adoles- cent psychiatry.

The Veterans Administration Medical Center inpatient addictions rotation has been enhanced with greater involvement of the Treatment Research Center. TRC staff are graciously offering their time for supervision and teaching, including didactics on motivational interviewing. Laura McNicholas, MD, PhD has been active in creating a mandatory free buprenorphine cer- tification course for all PGY-3 and PGY-4 residents. Valerie Nordquist, MD is creating a semi- nar with a focus on accessing and utilizing Alcoholics /Narcotics Anonymous, with speakers and an introduction to the twelve steps.

Our “crash course in psychiatry” for interns has been reformatted to create an intensive teaching curriculum that includes a psychopharmacology review, consultation/liaison issues and “real world” practical didactics on emergency psychiatry, including medical emergencies, clinical interviewing, managing involuntary commitments, and capacity evaluations.

Samar Jasser, MD and the chief residents are working together to create a website and resi- dent manual that will include resident-based information, pivotal articles in psychiatry, and a detailed handbook of evidenced-based practice guidelines and protocols. John O’Reardon, MD is also assisting this project by contributing his extensive collection of psychopharmacol- ogy notes and lectures.

Movie Club, a popular event last year, will continue with Anthony Rostain, MD, Henry Bleier, MD and other faculty members screening and discussing movies, including The Squid and the Whale and Tarnation. All are welcome to attend!

Lisa Rosenthal, MD has restarted the Community Psychiatry elective with seminars which include consumers, advocates, providers, and policy makers in the public mental health sys- tem (and dinner!), and field trips that include shelters, jails, residential programs, psychoso- cial rehabilitation programs, and a state psychiatric hospital.

Kate Blumner, MD, MPH also has been active in creating a seminar entitled “Alternative Treatments in Psychotherapy.” Her recent seminar focused on hypnosis with Peter Bloom, MD as a discussant.

We look forward to these exciting developments and more in the coming months! O

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FROM THE HUP INPATIENT CHIEF RESIDENT --Kari Groff, MD

edical student education is an important aspect of the Penn psychiatry program. This year, Mwe find more and more senior residents returning to the inpatient side of psychiatry to teach medical students and junior residents. Every Wednesday and Friday morning, we have a special medical student morning report run by the HUP chief resident, as well as many hours of direct one- on-one supervision and clinical observation on the Consultation-Liaison Service by senior residents. Several fourth-year residents are working as junior attendings and provide valuable leadership skills and exceptional teaching to the medical students and junior residents. They bring the perspec- tive of outpatient experience back to the inpatient unit and the Consultation-Liaison Service. Residents have also been involved in teaching Brain and Behavior and the Doctor-Patient inter- viewing course to the first and second-year medical students. The medical students have given excellent feedback with regard to resident teaching. We look forward to continuing to enhance med- ical education, working closely with the medical student education director, Benoit Dube, MD. This year, we are continuing Professors Rounds on Friday mornings and welcome many esteemed Penn faculty members to Founders 11 to participate in this activity. Professors Rounds are geared toward enhancing resident education, patient care, and introducing residents to some of our more senior faculty. On that note, we will also be having a Masters Dinners series with senior faculty members and residents at the Chairman's house. We look forward to a rewarding year of both learning and mentorship. The chief residents have made medical education a priority in their work this year and are excited to participate in this long tradition of Penn teaching. O

THE FAMILY SYSTEMS PROGRAM IN THE GENERAL RESIDENCY Ellen Berman, MD and Robert Garfield, MD

he couple and family sys- become familiar with com- support of partners and fami- Ttems program in the mon family and couples ly is critical to the patient’s Department of Psychiatry, issues and developmental recovery from illness. under the direction of Ellen milestones faced by adult According to national resi- Berman, MD and Robert children and their parents dency training guidelines, Garfield MD, is now fully throughout the life cycle, residents must learn the abil- integrated into all four years especially in the presence of ity to communicate with, of training in adult psychia- psychiatric illness in either assess, and educate patients try. The program teaches a generation. A separate mini- and families. In addition, systems orientation to psy- course covers sexual function they need to be familiar with chiatric care, emphasizing and dysfunction and sexual the basics of family therapy. the critical role family mem- orientation issues. The pro- bers play in successful treat- gram’s fundamental message The Penn Psychiatry family ment and how best to is that families are an asset to systems training program is involve and support patients the psychiatrist's work rather now recognized nationally and their families in the ther- than a burden. for its extensive and compre- apy regimen. Residents hensive nature. The curricu- Research has shown that the lum has been presented at Continued on page 25

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Continued from page 24

major conferences, including In the PGY-4 year, course- Classes are taught using an the American Association of work focuses on specific tech- extensive video collection of Directors of Residency Train- niques of couples therapy movies and demonstration ing and Academic Psychiatry. and common relational issues tapes. Role play is an integral Dr. Berman is also the Chair (for example, secrets and part of the process, to hone of the Family Committee of skills of dealing with multi- the Group For Advance- ple family members at ment of Psychiatry and once. Personal reflection Chair of the Association is an important part of of Family Psychiatrists, training, as one's own his- allied with the American tory and beliefs are par- Psychiatric Association. ticularly likely to affect She is co-author of a text- one's ideas of what is nor- book, Marital and Family mal for families. Unlike Therapy, and articles on the majority of residency the state of family sys- training programs, family tems training in psychia- systems thinking is intro- try in this country. duced at adult inpatient and outpatient sites, The program begins in rather than limited to the PGY-1 and 2 years child and geriatric set- with faculty demonstra- Robert Garfield, MD and Ellen Berman, MD tings or family clinics. tions of family interviewing This encourages residents to on the inpatient unit. The affairs, substance abuse, fami- see how family involvement goal is to teach residents how ly violence, and divorce and can be useful in psychiatric family systems affect psychi- remarriage) that are frequent- treatment in most patient atric illness and hospitaliza- ly seen in both individual and populations, although family tion, to learn about caregiver family therapy. Residents therapy is not always neces- burden, and to understand observe an ongoing couples sary. how families can be support- therapy case conducted by a ed in their care of the patient. senior faculty person. Family Current instructors in the Concurrent lectures introduce systems training is also repre- program include David systems concepts and review sented in the coursework for Wohlsifer, DHS,LCSW,MSW normal family development the psychotherapy track. (who was instrumental in and attachment theory. beginning the program), By the end of the program, Mickey Bernstein, MD, Benoit In the PGY-3 year, the resi- residents are expected to Dube, MD, Guy Diamond, dents observe faculty assess- complete numerous evalua- PhD, Nancy Gambescia,PhD. ments of outpatient couples tions of individual patients Carol Gantman, PhD, C. and adult children and their with their “significant others” Wayne Jones, PhD, Deborah parents, and coursework or other family members, and Luepnitz, MD, Bill Oberfield focuses on the theory and to have conducted at least MD, Anthony Rostain, MD, practice of assessment. Resi- two couple and two family and Leda Sportolari, MSW dents begin to do evaluations therapy cases. For residents LCSW. The family systems of the families or partners of wishing more in-depth expe- faculty are well-known at the their individual outpatients, rience, a family therapy elec- local and national levels, and and often begin one or two tive is available. many have published widely family therapy cases. Systems in the field. O supervisors support their Several teaching methods are work. widely used in the program.

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Department of Psychiatry On July 8, members of the Department of Psychiatry’s extended family gathered at the home of Dr. and Mrs. Evans to take part in the annual departmental picnic. The event introduces new housestaff to the Department and their new colleagues, and is always a wonderful opportunity for new and old members of the Depart- ment to reconnect. The sun shone warmly on the lawn of the Evans’ home as the children, parents, and grand- parents delighted in clowns and ice cream. Everyone enjoyed the activities, food and fellowship, and the annual picnic was a fitting start for a new and exciting year in the Department of Psychiatry. 2006 Annual Family Picnic

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Calendar of Events

PSYCHIATRY GRAND ROUNDS 12:00-1:00 pm BRB II/III Auditorium SEPTEMBER 2006 7 Dissecting the Disease Process of Schizophrenia: From Pathogenetic Mechanisms to Treatment Interventions David A. Lewis, MD, Professor, Departments of Psychiatry and Neuroscience; Director, Translational Neuroscience Program; Director, Conte Center for the Neuroscience of Mental Disorders; University of Pittsburgh 21 Translational Research in Schizophrenia: Promises and Challenges Raquel E. Gur, MD, PhD, The Karl and Linda Rickels Professor; Vice Chair for Research Development, Departments of Psy- chiatry, Neurology & Radiology; Director, Neuropsychiatry Section; University of Pennsylvania OCTOBER 5 Psychosocial and Pharmacological Interventions for Improving Functional Outcomes in Schizophrenia Stephen Marder, MD, Professor of Psychiatry; UCLA Medical Center 19 Title TBA - Psychosis Module (Case Presentation) Christian Kohler, MD, Associate Professor of Psychiatry and Neurology, University of Pennsylvania NOVEMBER 2 Genetics of Bipolar Disorder Wade Berrettini, MD, PhD, Karl E. Rickels Professor of Psychiatry; Director, Center for Neurobiology and Behavior; Universi- ty of Pennsylvania 9 Title TBA James L. Stinnett, MD, Professor Emeritus of Psychiatry; University of Pennsylvania Dr. Stinnett’s portrait unveiling and reception will follow in the BRB II/III Lobby. 16 Marijuana and the Endocannabinoid System: Promises and Problems Herbert D. Kleber, MD, Professor of Psychiatry; Director, Division of Substance Abuse; Columbia University College of Physicians & Surgeons; New York State Psychiatric Institute 30 Interventions for Cocaine Charles A. Dackis, MD, Assistant Professor of Psychiatry; University of Pennsylvania DECEMBER 14 Title TBA -- Substance Abuse Module (Case Presentation) Kyle Kampman, MD, Associate Professor of Psychiatry; University of Pennsylvania

JANUARY 2007 11 Neurobiology and Suicide J. John Mann, MD, Paul Janssen Professor of Translational Neuroscience in Psychiatry and Radiology, Columbia University; Chief, Department of Neuroscience, New York State Psychiatric Institute 25 Cognitive Therapy for Suicide Prevention Gregory K. Brown, PhD, Research Associate Professor of Clinical Psychology in Psychiatry; Associate Director, Center for Intervention and Prevention of Suicide; University of Pennsylvania FEBRUARY 8 Title TBA -- Suicide Module (Case Presentation) Aaron T. Beck, MD, Professor Emeritus of Psychiatry; Director, Center for Intervention and Prevention of Suicide; University of Pennsylvania 22 Translational Research and Suicide David Brent, MD, Professor of Psychiatry; University of Pittsburgh MARCH 22 Depression and Menopause Ellen W. Freeman, PhD, Research Professor, Departments of Obstetrics & Gynecology and Psychiatry, University of Pennsyl- vania APRIL 5 Translating Research on Mechanisms of Neurodegeneration into Disease Modifying Therapies John Q. Trojanowski, MD, PhD, William Maul Measey-Truman G. Schnabel, Jr, MD Professor of Geriatric Medicine and Gerontology; Director, Institute on Aging; Director, Alzheimer’s Disease Center; Co-Director, Center for Neurodegenerative Disease Research and Marian S. Ware Alzheimer Drug Discovery Program, University of Pennsylvania 19 Psychological Distress, Aging, Neurodegeneration and Dementia Steven E. Arnold, MD, Associate Professor of Psychiatry and Neurology; University of Pennsylvania M AY 3 Title TBA -- Neurodegenerative Module (Interventions) Bruce G. Pollock, MD, PhD, FRCPC, Sandra A. Rotman Chair in Neuropsychiatry & Head, Division of Geriatric Psychiatry, University of Toronto; The Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto 17 Title TBA -- Neurodegenerative Module (Case Presentation) Daniel Weintraub, MD, Assistant Professor of Psychiatry and Neurology, University of Pennsylvania

The Psychiatry Grand Rounds schedule will be posted on-line on the Department of Psychiatry web site at www.med.upenn.edu/psych

PENN PSYCHIATRY PERSPECTIVE O FALL 2006 Non-Profit Org. U.S. Postage PAID Permit No. 2563 Department of Psychiatry Phil., PA 19104 Office of the Chairman 3 Blockley Hall 423 Guardian Drive Philadelphia, PA 19104-6021 Telephone: (215) 662-2818 Fax: (215) 662-6911 www.med.upenn.edu/psych

PENN PSYCHIATRY PERSPECTIVE Editor: Rosellen Taraborrelli Telephone: (215) 662-2899 E-mail: [email protected] Co-Editor: Abigail Mason Woodworth Telephone: (215) 898-0602 E-mail: [email protected] Writing and Design: Williams-Campbell Administrative Services, LLC