Grant report 2020 Benefiting people and society 2 | The Novo Nordisk Foundation’s Grant Report 2020
Content
04 Ex traordinary year in the 24 The four grant-giving 51 S tandard for good research shadow of the COVID-19 models practice crisis 26 Theme: Biotech 53 Data ethics 06 The 2019–2023 strategy 30 Theme: Pioneering research 54 R ules of eligibility 07 The decisions of the Board of Directors on grants 34 Theme: Supporting all 55 R esearch funding and costs career stages covered by NNF grants 08 Theme s in grant-giving areas 56 Grants and payouts in 2020 10 Suppor ting the research, education and innovation 58 Committees environments 38 Impact assesment 60 T ables on committee 12 Theme: New foundations 40 Theme: Covid-19 members
16 F acts and figures 48 Diversity policy 79 Scien tific and non-scientific- purposes 22 P olicy on grant-giving 50 Code of conduct The Novo Nordisk Foundation’s Grant Report 2020 | 3
Theme: New foundations Theme: Supporting all career stages Data ethics 12 34 53
22 48 56
Policy on grant-giving Diversity policy Grants and payouts in 2020 4 | The Novo Nordisk Foundation’s Grant Report 2020
Extraordinary year in the shadow of the COVID-19 crisis
2020 was an extraordinary year for the Novo establishing two independent commercial The financial results of Novo Nordisk A/S and Nordisk Foundation. We once again increased foundations: the BII Foundation and the LIFE Novozymes A/S and the successful investments our total payout in 2020 for purposes that benefit Foundation. The purpose of the BII Foundation of Novo Holdings A/S enable the Foundation society and, for the second year in a row, we is to ensure that the efforts to promote excellent to continue to increase its grant-giving activities received a record number of applications from research and new ideas within the life sciences and thereby providing opportunities to scientific, applicants throughout Denmark and the other are translated into new scientific discoveries, into humanitarian and social purposes. Nordic countries. new products and solutions to benefit people and society. The purpose of the LIFE Foundation is to Continued support The Foundation awarded grants totalling DKK 5.5 strengthen interest and education in the natural In the coming years, the Foundation will billion and paid out DKK 4.6 billion for scientific, sciences among children and young people. Both continue to support research, education, humanitarian and social purposes, the highest foundations stem from large ambitious projects innovation and hospital activities as well as annual payout amount in the Foundation’s history. we started years ago and they now have optimal social and humanitarian causes that can improve framework conditions to fulfil their missions and people’s lives and contribute to the sustainable We supported more than 750 new projects goals as independent foundations. development of society. We will continue to within such areas as the medical sciences, support more initiatives that can help mitigate the natural and technical sciences, biotechnology, COVID-19 initiatives consequences of the COVID-19 pandemic, which diabetes treatment, education, innovation and In March 2020, the Foundation launched the first is not over yet. humanitarian and social causes. This reflects the of a series of COVID-19-related initiatives based on breadth of the Foundation’s grants. our desire to help to mitigate the consequences of We will also further strengthen all our other grant the pandemic. We did this as a supplement to our areas. We support the best projects and hope that these usual and already planned grant-giving activities. will lead to new scientific breakthroughs and the This report contains information about our grant creation of new knowledge and new solutions We also provided grants for TestCenter Denmark activities in 2020, including examples of the benefitting society. and supported global initiatives in areas with projects supported, our grant-giving policy and humanitarian crises. an overview of our scientific committees that New initiatives in 2020 included grants for several assess the applications for grants submitted to the research projects on the green transition, a high In total, we allocated DKK 420 million during 2020 Foundation. priority for the Foundation. The largest of these across 85 COVID-19-related projects. grants was DKK 750 million awarded to the Novo I hope you enjoy reading it. Nordisk Foundation Center for Biosustainability The companies behind the increase in grants at the Technical University of Denmark, a In 2020, Novo Holdings A/S, the Foundation’s global leader in developing new knowledge wholly owned investment and holding company, and technology that can promote sustainable recorded income and returns of DKK 29 billion, Lars Rebien Sørensen solutions, especially in biomanufacturing. with just under half coming from the stake in Novo Chairman of the Board Nordisk A/S and Novozymes A/S, and just over Establishing new foundations half coming from Novo Holdings’ investments in Other significant initiatives in 2020 included other companies and financial assets. The Novo Nordisk Foundation’s Grant Report 2020 | 5 6 | The Novo Nordisk Foundation’s Grant Report 2020
The 2019–2023 strategy
The Novo Nordisk Foundation Strategy 2019– 2023 presents the Foundation’s grant-giving areas, development targets and prioritized actions. Read more about our strategy on our homepage: www. Patient-centred and research-based care Education and outreach novonordiskfonden.dk Make Denmark a global leader in delivering Support general science education and cultivate care for people with diabetes and facilitate scientific and technical competencies and The Foundation’s pay-out has increased from DKK development of patient-centred and engagement. 3.6 billion in 2019 to DKK 4.6 billion in 2020. The researchbased care within diabetes comorbidities annual amount of grant-awarding has increased and other endocrine disorders. from DKK 4.9 billion in 2019 to DKK 5.5 billion in 2020.
The NNF vision The vision of the Novo Nordisk Foundation Life science research and industrial applications Innovation is to contribute significantly to research and promoting sustainability Create and promote a life science ecosystem that development that improves the lives of people Act for and inspire the development of a more increases the capacity for research institutions, and the sustainability of society. sustainable world by supporting research that clinics and start-ups to mature and trans-late translate into life science solutions to benefit scientific discoveries into products and solutions The grant-giving areas and long-term goals people and the environment. for the benefit of people and society.
Biomedical and health science research and Natural and technical science research and Social, humanitarian and development aid applications interdisciplinarity Improve lives and prospects of vulnerable Enable people to live healthier and better lives Catalyze natural and technical science research, children and youth through education, by facilitating research that advances knowledge particularly in fields with potential interdisciplinary competency development and health initiatives. of human health and disease, solves health application to the life and health sciences and challenges and develops the healthcare system. industrial biotechnology
Read more about the strategies www.novonordiskfonden.dk/da/strategiog- maal/ The Novo Nordisk Foundation’s Grant Report 2020 | 7
The decisions of the Board of Directors on grants
The Board of Directors decides the Foundation’s Directors, or on behalf of the Board of Directors You can read more on the decision-making strategy, vision, payout ambition, the annual by 28 expert committees, the Chairmanship and process at the Foundation’s homepage: grant giving budget and the grants. The decisions the Executive Office that implement the Boards’ https://novonordiskfonden.dk/en/about-the- on grants are decided directly by the Board of decisions. foundation/the-decisions-of-the-board-of- directors-on-grants/ 8 | The Novo Nordisk Foundation’s Grant Report 2020
Themes in grant-giving areas
Specific focus themes in the strategy period: Life science research and industrial applications • Facilitate knowledge-sharing and promoting sustainability dissemination of research results to guide Biomedical and health science research Industrial Biotechnology science teachers and policy makers. applications • Solve fundamental challenges within bio-based Health-related data science production and technologies. Vocational education and training • Development and exploitation of health- • Increase the skills and output of well-qualified related data for research and development of Plant Science and Agriculture and motivated graduates for vocational new diagnostics and treatments. • Provide more productive and resilient occupations, related to biotechnical and • Combining data-science with clinical plants by addressing challenges related to biomedical disciplines as well as IT and experience and designing new validation development and cultivation of plants. technology in general. models for personalized/precision medicine interventions. Food Biotechnology Science communication and informal learning • Develop sustainable and safe food products environments Innovative therapies feeding the growing population. • Raise awareness, knowledge and appreciation • Innovative therapies based on cutting edge • Environmental Biotechnology and Ecosystems of science and technology among children, biomedical/biotechnical research. research families and the general population. • New therapeutic strategies based on e.g. gene • Develop biological tools and solutions with a • Support humanities research related to new editing techniques, and a suggested national global impact on the environment. technologies. infrastructure to support cell-based therapies. • Help to secure fact-based, constructive societal Education and outreach debates around science and technology and Coherence in health care STEM education build a stronger voice for the importance of • Focus on research into cohesive health care • Promote excellent and inspiring education for research. and research into implementation of new children and young people in natural science research-based solutions. and technology by strengthening teaching Research in art and art history • Focus on how changes in demography and resources and methods – from day-care • Support research which challenge existing partially curative treatments change the through upper-secondary education. dogmas, inspire new ideas and improve composition of the future patient population in • Enhance competencies of pedagogues and people’s life. Denmark. teachers of STEM disciplines. • Support cross-disciplinary research within art and natural science which may put science Breadth in biomedical research-commitment and LIFE matters into perspective. integration • Support LIFE as the overarching strategic • Program for recruitment of research leaders, initiative within education. thematic calls in existing instruments in open competition, and collaborative medical Research in science education projects, and instrument for grantees to pursue • Identify and promote national and international unexpected findings. best teaching practices within natural sciences and technology. The Novo Nordisk Foundation’s Grant Report 2020 | 9
Social, humanitarian and development aid Co-morbidities to diabetes Innovation Overweight and obesity among children and youth • Integrated care for diabetes patients with co- Support the talent base in Denmark morbidities. • Attract international talents and develop the • Reduce overweight among children, primarily skill set among students, researchers, and through prevention among pre-school children. Endocrinology other than diabetes clinicians, to increase their potential to explore • Strengthening learning opportunities among • Improve quality of clinical practice for patients and perform activities translating discoveries. vulnerable children in Denmark with endocrine disorders other than diabetes. • Improve learning opportunities for vulnerable Support infrastructure children through early interventions. Natural and technical science research and • Support access to Research Infrastructure, Test interdisciplinarity Facilities and Expert Teams in Innovation to Youth education and empowerment in Jordan, Nat-X increase the translational potential of a project. Lebanon and potentially Syria • Significant breakthroughs in understanding • Improve the prospects and possibilities of the fundamental mechanisms governing life, Open Innovation young refugees from Syria through quality health and biotechnology achieved by joining • Create new models which change the way education and other learning opportunities. forces between biologists, chemists, physicists, academia and industry are interacting, engineers, and computational scientists. ultimately accelerating innovation. Non-Communicable Diseases in eastern Africa, Jordan, Lebanon and potentially Syria Q-Life Attract capital and investors • Reduce NCD mortality by supporting • Solve complex and important problems in • Stimulate a larger number of investors from prevention and treatment in developing biology, chemistry and medicine - problems the public and private space to fund research countries and humanitarian settings. which are currently unsolvable - through the driven discoveries. realization of quantum simulators and novel Patient-centred and research-based care quantum technologies. BioInnovation Institute Implementation of Steno Diabetes Centres • Support BII as the overarching strategic • Improve quality of life, prevent complications Dat-Mat core initiative within innovation. of diabetes and create longer life expectancy • Develop tomorrow’s ground-breaking for diabetes patients. algorithms for handling and understanding Big Data with applications in artificial intelligence, Steno DK machine learning and bioinformatics through • Enhancing collaboration across the Steno a strengthening of fundamental and applied Diabetes Centres network, the Copenhagen research in mathematics and computer Bioscience Cluster, Steno Collaborative Grants science. and other relevant activities. Tech-med Steno Diabetes Centre Greenland • Transform tomorrow’s therapies and • Improve public health and quality of life for diagnostics and significantly progress human patients with diabetes and other lifestyle- health and society through advances in related diseases in Greenland. the technical sciences and engineering technologies. 10 | The Novo Nordisk Foundation’s Grant Report 2020
Supporting the research, education and innovation environments
The Novo Nordisk Foundation provides support The Novo Nordisk Foundation supports research for high quality research and research talents environments and institutions to fulfil their own The support is offered through a range of different research ambitions and plans funding instruments. The Foundation wishes to Through its funding, the Foundation offers a strengthen research in Denmark and the Nordic supplement to public research, and our ambitions countries, while contributing to knowledge creation is to improve the quality of scientific research and growth that may pave the way to societal and contribute to a strong and dynamic research development and sustainable solutions that benefit environment. We respect the universities’ own people and society. strategies and priorities and engage in a dialogue with the institutions. As a significant contributor of research funding to universities and research hospitals, the We support researchers in all career stages – Novo Nordisk Foundation adopts a long-term from PhD students and postdocs to associate perspective. Scientific research involves risk-taking professors and professors. The Foundation and achieving results can be time consuming. also contributes to education, dissemination of knowledge, commercialization, research-based The Foundation has a wide range of grants that innovation and infrastructure at the research target the needs of the universities and researchers. institutions. We support the whole value chain that The Foundation supports large as well as small creates solutions for people and society. research centres, research programmes and projects at the Danish universities, hospitals and other research institutions. The Novo Nordisk Foundation’s Grant Report 2020 | 11
Read more about the Foundation’s initiatives in this area on the following pages. 12 | The Novo Nordisk Foundation’s Grant Report 2020
Tema:Theme: Biotek New foundations The Novo Nordisk Foundation’s Grant Report 2020 | 13
Two new foundations will strengthen innovation and boost education in Denmark In December 2020, the Novo Nordisk Foundation established two new independent commercial foundations, the BII Foundation and the LIFE Foundation (next page). These foundations have very different objectives but are both driven by the ambition of strengthening Denmark in important areas.
BII Foundation – boosting research, entrepreneurship and company creation
The BioInnovation Foundation (BII Foundation) was created based on a desire of Directors decided in November 2020 that the time was ripe to launch BII to translate more research discoveries within the life sciences into new products on December 1st, 2020 as an independent international non-profit foundation and solutions to benefit people and society. Life science research in Denmark to ensure long-term and ambitious development within the life sciences and and the other Nordic countries is of a high international calibre, but many ideas biotechnology. and results are never developed into actual products because of a lack of development facilities, experienced personnel and access to risk capital. As an independent foundation, the BII Foundation now has its own Board of Directors and a more flexible and stronger framework to be able to fulfil its In December 2017, the Novo Nordisk Foundation awarded a grant of DKK purpose. Sten Scheibye chairs the Board of Directors, which includes many 392 million to establish the BioInnovation Institute (BII) in Copenhagen. Here, experienced and highly competent members with entrepreneurial backgrounds. talented researchers and entrepreneurs can receive financial support and help to develop research projects until they can obtain funding on market terms. “The BioInnovation Institute has received a fantastic reception from researchers and entrepreneurs. This is why we have now established it as an independent The Novo Nordisk Foundation awarded the grant over a 3-year period with the foundation, so we can ensure a targeted and long-term effort to advance aim of spinning off the BII as an independent foundation once the project was outstanding research and new ideas to become solutions that benefit society,” firmly established. In 2019, the Novo Nordisk Foundation awarded an additional says Birgitte Nauntofte, CEO, Novo Nordisk Foundation. DKK 73 million to the BII to accommodate the tremendous interest expressed by researchers and entrepreneurs in its services. Jens Nielsen, former professor at Chalmers University of Technology and scientific director at Center for Biosustainability, DTU, who has led the Over the past 2 years, more than 85 research projects and innovation projects development of BII since 2018, is the CEO. have thus received support through the BII for developing new products and solutions within the life sciences, including for developing new drugs, health The Novo Nordisk Foundation intends to provide funding of up to DKK 3.5 technologies and biotechnological solutions that can contribute to the green billion to the BII Foundation over a 10-year period. Establishing it as a commercial transition. foundation also enables other organizations and foundations to take part in its long-term funding, ensuring that it can become an even stronger catalyst for Optimal framework developing new discoveries and solutions to benefit people and society. Following the successful start-up phase, the Novo Nordisk Foundation’s Board Read more at bii.dk. 14 | The Novo Nordisk Foundation’s Grant Report 2020
Theme: New foundations The Novo Nordisk Foundation’s Grant Report 2020 | 15
LIFE Foundation – long-term initiative in the natural sciences
The LIFE Foundation is an independent non-profit foundation with corporate have available themselves. The truck travels around and visits schools across interests that has been established to strengthen children and young people’s Denmark and is staffed by LIFE employees who can lead the experimental work knowledge and fascination with science. Innovation in science and technology is in collaboration with the class teacher. In the long term, LIFE intends to have five crucial for developing new solutions to many of society’s challenges, and young such mobile laboratories. people therefore need to be inspired to educate themselves and choose a career in the field in the long term. Finally, a large physical learning laboratory for visiting school classes is being established in Kgs. Lyngby and is expected to open in 2021. LIFE (Learning, Ideas, Fascination and Experiments) develops and provides inspiring learning courses within the natural sciences for use in teaching in Experienced Board of Directors primary and secondary schools throughout Denmark. Schools can use the After the first 2 successful years, in November 2020 the Novo Nordisk courses free of charge. Foundation’s Board of Directors decided to establish LIFE as an independent foundation. On 1st December 2020, similar to the BII Foundation, the LIFE Foundation was spun off an existing project under the Novo Nordisk Foundation, which in April The LIFE Foundation has a Board of Directors with extensive experience from the 2018 awarded a grant of DKK 123 million to establish LIFE and to pay for LIFE’s education sector and the natural sciences. Jesper Fisker, Managing Director of start-up costs over its first 2 years. the Danish Cancer Society and a former State Secretary of Denmark’s Ministry of Children and Education, chairs the Board. In these 2 years, LIFE has developed and tested several courses that have been used since August 2020 at more than 135 schools throughout Denmark. Students Christine Antorini, Denmark’s former Minister of Children and Education, who has use the LIFE courses to work based on research with case-based issues from the led the development of LIFE since 2018, is the CEO. real world that also support achieving the Sustainable Development Goals. The courses include actual hands-on experiments and digital learning activities and “As an independent foundation, LIFE has an optimal framework for becoming equipment and materials called LIFE kits, which can be ordered free of charge a nationwide, long-term and sustained educational initiative that can enhance from LIFE. education and research in the natural sciences and contribute to strengthening the knowledge of and fascination for science among children and adolescents,” Close collaboration says Birgitte Nauntofte, CEO, Novo Nordisk Foundation. LIFE courses have been developed in close collaboration with schools, companies and research institutions. All LIFE courses fulfil the Common The Novo Nordisk Foundation intends to award the LIFE Foundation grants of Objectives in primary and lower-secondary schools or the learning objectives for up to DKK 1.9 billion in the first 10 years. Other foundations and actors may also upper-secondary schools. support the LIFE Foundation.
LIFE has also designed a mobile laboratory, the LIFE Mobile Lab, which is fully equipped with advanced laboratory equipment that schools do not necessarily Read more at life.dk 16 | The Novo Nordisk Foundation’s Grant Report 2020
Facts and figures 2020 The Novo Nordisk Foundation’s Grant Report 2020 | 17
Overall grants in 2020
5,540 DKK million awarded
4,634 DKK million paid out
4,410 applications received
756 grants awarded
20% Share of applications awarded a grant in open competition 18 | The Novo Nordisk Foundation’s Grant Report 2020
Amount granted in 2020 by grant-giving areas (DKK million)
414 Education and outreach
585 446 Patient-centred and Innovation research-based care
5,540 Total amount 324 1,908 Social, humanitarian Biomedical and health and development aid science research and applications
1,346 518 Life science research and Natural and technical industrial applications science research and promoting sustainability interdisciplinarity The Novo Nordisk Foundation’s Grant Report 2020 | 19
Grants awarded by administrative region in Denmark, 2020 (DKK million)
*) Excludes unsolicited applications
North Denmark Region Number of applications* 543 Number of grants 104 Share awarded a grant 19% Granted amount (DKK million) 671
Central Denmark Region Capital Region of Denmark Number of applications* 642 Number of applications* 1,923 Number of grants 132 Number of grants 432 Share awarded a grant 21% Share awarded a grant 22% Granted amount (DKK million) 786 Granted amount (DKK million) 3,681
Region of Southern Denmark Number of applications* 291 Number of grants 50 Share awarded a grant 17% Granted amount (DKK million) 223 Region Zealand Number of applications* 89 Number of grants 17 Share awarded a grant 19% Granted amount (DKK million) 114
Grants awarded outside Denmark, Finland Norway Sweden Other in collaboration 2020 (DKK million) with Danish organizations Number of applications* 123 63 255 104 Number of grants 19 9 56 19 Granted amount (DKK million) 57 24 148 440 Share awarded a grant 15% 14% 22% 19% 20 | The Novo Nordisk Foundation’s Grant Report 2020
Development in grant-awarding Number of employees either activities, 2016-2020 fully or partly funded by the *Excludes unsolicited applications Foundation, 2016-2020 *Number of employees does not include employees at the five Steno Diabetes Centres in Denmark **) Preliminary estimate
4000 6000 3500
3000 5000
22% 2500 4000 20% 2000 20% 3000 1500 19% 19% 2000 1000
1000 500
0 0 2016 2017 2018 2019 2020 2016* 2017* 2018* 2019 2020**
Number of rejections Number of grant recipients Share awarded a grant Number of other personnel Number of PhD Number of Postdoc
Grant recipients by gender, 2016–2020
20% men
19% women
0 1000 2000 3000 4000 5000 6000 7000 8000 9000 10000
Number of applicants Number of grants Share awarded a grant within the gender The Novo Nordisk Foundation’s Grant Report 2020 | 21
Grant recipients by age, 2016-2020
5000
4000
3000
2000
1000
0 20-29 30-39 40-49 50-59 60-69 >70
Number of rejections Number of grants
The Foundation’s grants and payouts, 2016–2020 *DKK million
Grants Payouts 5,839 5,540 4,892 4,634 4,202 3,891
3,606
1,749 1,308 1,133
2016 2017 2018 2019 2020 22 | The Novo Nordisk Foundation’s Grant Report 2020
Policy on grant-giving
The Board has established a policy on grant-giving. The objective is to support projects of the highest quality in accordance with the Foundation’s strategy and national and international standards for assessment, evaluation and grant-awarding practices.
Grant-awarding principles collaboration to catalyze advances in national Accessibility The Board has set out the following overarching and international partnerships. The Foundation The Foundation champions broad dissemination grant-awarding principles for what the Foundation celebrates the coming together of unique and access to scientific knowledge and results. will emphasize and seeks to uphold in all its grant- and differing ideas and perspectives to tackle Making the scientific knowledge and results awarding activities. challenges and develop solutions in new ways. available to other people is pivotal to catalyzing The Foundation fosters collaboration between further advances in any field. The Foundation Excellence people and organizations to improve results, believes in the value and importance of this and The Foundation pursues the highest standard of including across universities, hospitals, schools promotes this in all its grant-awarding activities. quality in all it does and supports. The Foundation and geographical borders. The Foundation is committed to excellence and quality in all supports strategic international collaboration and Diversity its activities. Only by setting a high standard partnerships. The Foundation will promote an inclusive will real, sustainable impact be achieved. The culture through the formulation of specific Foundation will strive for excellence and expects Innovation expectations not only to ourselves but also to all the same of the people and institutions it supports The Foundation acknowledges and values the key stakeholders, including research institutions, to and with which it collaborates, nationally and potential of new ideas. The Foundation supports explain how they and their organization promote internationally. The Foundation is prepared to new ways of addressing challenging problems diversity and inclusion. The individual applicant take risks in areas in which it sees excellence and facing people and society. will not need to explain this in the application support promising projects to create the basis for process. breakthroughs. Supplementarity The Foundation sponsors activities that Center of gravity Interdisciplinarity complement and supplement current systems. The primary geographical focus of the The Foundation facilitates connectivity across The Foundation aims to create impact by Foundation’s grant-awarding activities will be disciplines to generate new ways to discovery. supplementing existing activities, systems and Denmark, followed by the Nordic countries. The Foundation believes that interdisciplinary funding. research will drive future waves of discovery and To strengthen research quality within the innovation. It advocates and supports the removal Respect center of gravity the Foundation supports of barriers between traditional disciplines and fields The Foundations supports free and independent internationalisation efforts via support of of research. It seeks to find new and more effective research. The Foundation respects other people’s collaborative research programmes and ways to solve complex problems at the intersection ideas and understands that producing landmark partnerships between Danish and international of various disciplines and to apply interdisciplinary results that benefit society can take time. It is institutions. approaches in the search for solutions to significant prepared to listen to other people’s views and global and societal problems. advice, and to take time to explain the reasons To support the center of gravity, the Foundation for its priorities and decisions. The Foundation will foster mutually beneficial relationships with Collaboration respects the freedom of research and does not partners internationally such as universities, The Foundation facilitates inclusiveness and claim rights to the results. international organisations and foundation peers. The Novo Nordisk Foundation’s Grant Report 2020 | 23 24 | The Novo Nordisk Foundation’s Grant Report 2020
The four grant-giving models
Applications and grants awarded are divided into the following four grant-awarding models.