DOCSLIB.ORG

Carrizozo News, 09-05-1919 J.A

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Carrizozo News, 09-05-1919 J.A University of New Mexico UNM Digital Repository Carrizozo News, 1908-1919 New Mexico Historical Newspapers 9-5-1919 Carrizozo News, 09-05-1919 J.A. Haley Follow this and additional works at: https://digitalrepository.unm.edu/carrizozo_news Recommended Citation Haley, J.A.. "Carrizozo News, 09-05-1919." (1919). https://digitalrepository.unm.edu/carrizozo_news/273 This Newspaper is brought to you for free and open access by the New Mexico Historical Newspapers at UNM Digital Repository. It has been accepted for inclusion in Carrizozo News, 1908-1919 by an authorized administrator of UNM Digital Repository. For more information, please contact [email protected]. OLDEST AND LEADING NEWSPAPER IN CIRCULATION IN THE COUNTY OF LINCOLN, NEW MEXICO tAKKI'.O.O. LINCOLN COUNTY. NKW MUXICO. FRIDAY. SISPTISMIIICK 5, Wi NUMHER jC C'ARRIZOZO SCHOOL NOIFS New Mexico to Build 483,28? Your Home Paper and trie High Institute Resolutions Oscuro News Notes birthday cake baked by Mrst lllack was a beauty. Miss Orltilc ) Miles ol Roads Cost ol living (It. Iv. li Tri-Coti- rccolved quite a number of pres- h' Oil The Institute ol In some localities there has been Tlie public school (if Carriinio Otero, Doua Ana and Lincoln ents. Santa I'V. New Mexico, Sept. I. Shoe uii'ii predict that bv nest uire rains, and griming is good, opened Monday morning with counties is drawing to a close Dr. West, wife and two little A of thirty-nin- e we once paid lor Stock is fat, gardens flue, orchards .'UIU pupils in attendance. total federal spring shoes it atmilt Your committee, in all honest splendid, though not n large daughters left Tuesday for their enrollment, assignment to aid highway project have been will he around $15 and $2U, After muleavor to learn the sentiments yield. The fruit is certainly home in Ilatavla, Illinois, having ctrteees Hinging of songs tin initiated in New Mexico since the Clothing peopie snv n very ordin- mitt of the members of this institute, delicious. lCvcry one seems to spent the past three months with were allowed tn go home United States "ufty-fifty- " plan ary suit will sell at $50, ami every plinlls find so great agreement on all he happy and of good cheer, for Dr. and Mrs. K'anulgcr. ilx- - was adopted in New Mexico. thing else wc wear will be in Tor the remainder of day. point considered that we offer 11. D. New Mexico ha hIiowii remark-aid- e price of the prospects are now a rush in Chamberlin, of HI Paso, The attendance in the liiiili proportion. Already the the following resolutions: tlie oil development. is doing clerical work in Mr. e, speed, insofar as the federal groceries ami furniture, in fact, school t thirty-fiv- and the 1. That we express our ap- provisions permit, in accepting of all necessities, is so high that KalTcty's oil olllce. teaching force n siiflleieut to do preciation of the splendid work The Canadian-America- n Oil & federal assistance in her road it makes a fellow's huud hurt to li, W. Ounyoii, of ItlO I wet work. In the high dntie by our instructors, and our Lousing company, of Vancouver, manager the building. Seven of the projects contemplate such soaring. And oil company is drilling school the following course gratitude to all others who have II, C, have taken over the rig that near have been fully approved with vet, amid it all, there is one lliliii; town, and Mrs. wife, English, four years; helped toward making the ses- and holdings of K. O. Kaffety, Gunyon, his construction underway, including that lias not kept pace in ascend went to Kl Paso last Friday, re- Hpnuittti, four yearn; Latin, four sions both pleasant and profitable. and arc now drilling after spend- nearly one litiudrcd mile of high-w.i- y iug price with other things a turning on Tuesday evening. jenini Commercial, lour years; 2. That we appreciate the ing a few days on repair work. on which a total of over civiliied people cannot well get Sciailce, four years; History, three privilege of holding our meetings They are going to carry the hole Kd. llowser has rented the S'fSU.OOO will he expended. Two along without ami that is your yearm Manuel Training, two in the heaulitul new buildings of on down from its present depth of building next to Chas. F. Orey's other projects have heeu approved home-tow- n paper. MM) years; Home Ikouomlcs, two the Otero County High School. feet. However, they are store, aud will open an oil olllce ami hid for their construction Don't stop reading there if you years; and Aicriculttire, one year. i. That wi express to the reaming out a 60 foot olTset that there. The Oscuro Uusiness Club will he opened the middle of are a d man. give TheHe courses art' being Just cttixeusof Alamogordoour thanks had been made, and are making a will also have u room there. September, involving some ten this a minute's thought. Is there strengthened in every possible for many courtesies uxtended. hole all the way down, miles of highway at an estimated anything that gives you the same There was two very prosperous way. The hool ha twelve I. That we extend congratula- which they intend keeping as cost of some $75,000. amount of enjoyment, the same looking oil men in town last benches for work in .Manual train- tions to Hip county superinten- lung as possible or as long as The plans and specifications amount of knowledge, the Haute week, and the report is, that they ing, n large equipment lor the dents ol Lincoln, Uoua Ana and they think best. They have a are ready for two more projects amount of valuable suggestions will be back in just a few days, Domestic Science department and Otero counties for the splendid car of coal coming, also another totalling sixteen miles at a cost and then serves worthy pur- I Canadian-America- n & teveti typewriters in the Com- aoine management shown and their driller. W. (iiinyon, geologist, The Oil of SJi'i.OOO. One project has pose that the home-tow- n payer Leasing Co, received of mercial dopartiueitt. A lirstcliiM spirit of devotion of Vancouver, is director and a car coal hecu ap proved hut construction does. Ami did you know that it Monday, which was unloaded tnhlo for work in Physics will he to the cause for which we stand.1 general manager. W. H. Tiller, and deferred; surveys ami plans are has yet never asked you to lay delivered at the oil rig. hllilt by the Manual TraiuiiiK S, We go on record as un- also of Vancouver, a director, is being made for eight more, ag- down your good money unless it classes and a splendid eipiipmuiit utterably opposed to the proposed here. J. Wcllbauk of the same A most enjoyable evening was gregating l'J'i miles, estimated met your every requirement. It lion heeu ordered for this amendment providing for placing place is on the joti, dressing tools, spent in the parlors of Mr. and cost id2 1,000. Approval has also is one thing vou can contract for the educational and penal institu- They have rented the 1'Mwards Mrs. C. F. Grey, by a social heeu asked for twelve more pro- - ami ipiil when you choose and liStmlinaU itrfll hi ttliiri'il nil tions of the state under one hoard Hotel building and in the store bunch of 50 players. Miss - you're still ahead of the game. work ill the common hrauches allU ,"".u"' of control. room part will have their ollices. Woods, our principal in the ') "e projected hns '..-heeu d.s-ho- Printer's ink, white pi per, type Along the line. We want ur fi. That the sentiment of this They have bought ami leased school, carried oil the grand hy the department of metal, labor, everything ami girl to read mid write nM'vl that institute is that all iullueucc more than 15,000 acres of laud. prize. Mr. Wcllbauk, a tool 1 wo have heeu goes into the making of your well; to he aide to spell well and "Br cjiHure. possible be brought to hear to There is unite a little Ira flic in dresser, won the booby prise. withdrawn on the request of home. (own paper has gone tip in llgure wull. After that a strong have formed a separate depart- leases now going on here. oll'ereil. county commissioners who wanted price as other things went up. high school course is ment of education with repre Harold Havens, geologist, of The President and tlie Shopmen We every hoy ami girl in others substituted. Hut we are asking you i:u more want sentation in the President's California, was here last week, ami get all The total mileage of projects money for youi paper. For that tile diltrict to come cabinet, as provided in the Smith- - and said: "I have been all over President Wilson has earned u under construction approved and reason, why wouldn't it he a good the education possible. Hducu-tlo- Punier Hill. the right to speak to the railroad for which statements are ready is idea to show your appreciation m' New Mexico, looking up the oil is the only thing on earth 7. ).SJ,2S7 That we go on record as possibilities, and around Oscuro shopmen as a friend. From that that it free to all. Kvcrythiiig miles and estimated total the one thing that has remained cost favoring medical inspection of is the most favorable pi.
Load more

Recommended publications
  • Molecular Basis for Heat Desensitization of TRPV1 Ion Channels
    ARTICLE https://doi.org/10.1038/s41467-019-09965-6 OPEN Molecular basis for heat desensitization of TRPV1 ion channels Lei Luo1,2,5, Yunfei Wang1,2,5, Bowen Li1,5, Lizhen Xu3, Peter Muiruri Kamau1,2, Jie Zheng 4, Fan Yang3, Shilong Yang1 & Ren Lai1 The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly 1234567890():,; understood, because rapid heat-induced desensitization (Dh) follows tightly heat-induced activation (Ah). To understand the physiological role and structural basis of Dh, we carried out a comparative study of TRPV1 channels in mouse (mV1) and those in platypus (pV1), which naturally lacks Dh. Here we show that a temperature-sensitive interaction between the N- and C-terminal domains of mV1 but not pV1 drives a conformational rearrangement in the pore leading to Dh. We further show that knock-in mice expressing pV1 sensed heat normally but suffered scald damages in a hot environment. Our findings suggest that Dh evolved late during evolution as a protective mechanism and a delicate balance between Ah and Dh is crucial for mammals to sense and respond to noxious heat. 1 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China. 2 University of Chinese Academy of Sciences, Beijing 100049, China. 3 Key Laboratory of Medical Neurobiology, Department of Biophysics and Kidney Disease Center, First Affiliated Hospital, Institute of Neuroscience, National Health Commission and Chinese Academy of Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
    [Show full text]
  • Sérgio José Macedo Júnior
    Sérgio José Macedo Júnior MECANISMOS ENVOLVIDOS NA NOCICEPÇÃO INDUZIDA PELO VENENO DA BOTHROPS JARARACA EM CAMUNDONGOS: EVIDÊNCIAS DA PARTICIPAÇÃO DOS RECEPTORES DE POTENCIAL TRANSITÓRIO TIPO ANQUIRINA 1 Tese apresentada ao Programa de Pós-graduação em Farmacologia do Centro de Ciências Biológicas da Universidade Federal de Santa Catarina como requisito para a obtenção do título de Doutor em Farmacologia. Orientador: Prof. Dr. Juliano Ferreira Florianópolis 2018 Agradecimentos À Deus, por me proporcionar as vivências, o aprendizado e os amigos que tive durante esse período valioso de minha vida. Aos meus pais Sérgio e Rita, por todo amor e dedicação. Obrigado pelo incentivo, apoio e por tudo que fizeram para que hoje eu pudesse estar vivendo este momento. Meu eterno obrigado. À minha irmã Ana Luiza (In memorian). Obrigado por guiar os meus passos, iluminar o meu caminho e continuar me ensinando que devemos valorizar cada momento e cada conquista no nosso dia. Ao meu orientador Professor Juliano. Obrigado por ter me acolhido nesses últimos quatro anos e por ter compartilhado comigo o seu conhecimento e principalmente a sua paixão pela ciência. Aos meus amigos do laboratório, Bauru, Débora, Marcella, Kharol, Camila e Muryel, obrigado pela ajuda nos experimentos, pelas discussões científicas, pelo cafés, pela conversa agradável e principalemente pela amizade. Aprendi muito com cada um de vocês e agradeço por terem passado em minha vida neste momento. Aos amigos que fizeram parte do lab Ferreira, Raquel (eterna chefa), Gerusa, Ney, Suélen e Mallone obrigado por compartilharem comigo seus conhecimentos, pela ajuda nos experimentos e pela amizade. Foi um prazer ter a companhia de vocês durante os últimos anos.
    [Show full text]
  • Investigation of Iron's Role in Alginate Production And
    INVESTIGATION OF IRON’S ROLE IN ALGINATE PRODUCTION AND MUCOIDY BY PSEUDOMONAS AERUGINOSA by JACINTA ROSE SCHRAUFNAGEL B.S., University of Colorado Denver, 2003 M.S., University of Colorado Denver, 2006 A thesis submitted to the Faculty of the Graduate School of the University of Colorado in partial fulfillment of the requirements for the degree of Doctor of Philosophy Molecular Biology Program 2013 This thesis for the Doctor of Philosophy degree by Jacinta Rose Schraufnagel has been approved for the Molecular Biology Program by David Barton, Chair Michael Vasil, Advisor Mair Churchill Jerry Schaack Michael Schurr Martin Voskuil Date 10/30/13 ii Schraufnagel, Jacinta R. (Ph.D., Molecular Biology) Investigation of Iron’s Role in Alginate Production and Mucoidy by Pseudomonas aeruginosa. Thesis directed by Professor Michael Vasil. ABSTRACT Iron, an essential nutrient, influences the production of major virulence factors and the development of structured non-alginate biofilms in Pseudomonas aeruginosa. Fur, pyoverdine and various concentrations of iron sources have all been shown to affect non-alginate biofilm formation. Remarkably however, the role of iron in alginate biofilm formation and mucoidy is unknown. Because of alginate’s association with biofilms in chronic cystic fibrosis (CF) lung infections, we examined the influence of iron on alginate production and mucoidy in P. aeruginosa. Herein, we identify and characterize a novel iron-regulated protein that affects the transcription of alginate biosynthesis genes. Further, contrary to what is known about non-alginate biofilms, we discovered that biologically relevant concentrations of iron (10 µM – 300 µM), in various forms (e.g. FeCl3, Ferric Citrate, Heme), led to the decreased expression of alginate biosynthesis genes and the dispersion of alginate biofilms in mucoid P.
    [Show full text]
  • TRPV Channels and Their Pharmacological Modulation
    Cellular Physiology Cell Physiol Biochem 2021;55(S3):108-130 DOI: 10.33594/00000035810.33594/000000358 © 2021 The Author(s).© 2021 Published The Author(s) by and Biochemistry Published online: online: 28 28 May May 2021 2021 Cell Physiol BiochemPublished Press GmbH&Co. by Cell Physiol KG Biochem 108 Press GmbH&Co. KG, Duesseldorf SeebohmAccepted: 17et al.:May Molecular 2021 Pharmacology of TRPV Channelswww.cellphysiolbiochem.com This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Interna- tional License (CC BY-NC-ND). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. Review Beyond Hot and Spicy: TRPV Channels and their Pharmacological Modulation Guiscard Seebohma Julian A. Schreibera,b aInstitute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany, bInstitut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Münster, Germany Key Words TRPV • Molecular pharmacology • Capsaicin • Ion channel modulation • Medicinal chemistry Abstract Transient receptor potential vanilloid (TRPV) channels are part of the TRP channel superfamily and named after the first identified member TRPV1, that is sensitive to the vanillylamide capsaicin. Their overall structure is similar to the structure of voltage gated potassium channels (Kv) built up as homotetramers from subunits with six transmembrane helices (S1-S6). Six TRPV channel subtypes (TRPV1-6) are known, that can be subdivided into the thermoTRPV 2+ (TRPV1-4) and the Ca -selective TRPV channels (TRPV5, TRPV6). Contrary to Kv channels, TRPV channels are not primary voltage gated. All six channels have distinct properties and react to several endogenous ligands as well as different gating stimuli such as heat, pH, mechanical stress, or osmotic changes.
    [Show full text]
  • Centipede Venoms As a Source of Drug Leads
    Title Centipede venoms as a source of drug leads Authors Undheim, EAB; Jenner, RA; King, GF Description peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation? show=aimsScope&journalCode=iedc20 Date Submitted 2016-12-14 Centipede venoms as a source of drug leads Eivind A.B. Undheim1,2, Ronald A. Jenner3, and Glenn F. King1,* 1Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia 2Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD 4072, Australia 3Department of Life Sciences, Natural History Museum, London SW7 5BD, UK Main text: 4132 words Expert Opinion: 538 words References: 100 *Address for correspondence: [email protected] (Phone: +61 7 3346-2025) 1 Centipede venoms as a source of drug leads ABSTRACT Introduction: Centipedes are one of the oldest and most successful lineages of venomous terrestrial predators. Despite their use for centuries in traditional medicine, centipede venoms remain poorly studied. However, recent work indicates that centipede venoms are highly complex chemical arsenals that are rich in disulfide-constrained peptides that have novel pharmacology and three-dimensional structure. Areas covered: This review summarizes what is currently know about centipede venom proteins, with a focus on disulfide-rich peptides that have novel or unexpected pharmacology that might be useful from a therapeutic perspective. We also highlight the remarkable diversity of constrained three- dimensional peptide scaffolds present in these venoms that might be useful for bioengineering of drug leads. Expert opinion: The resurgence of interest in peptide drugs has stimulated interest in venoms as a source of highly stable, disulfide-constrained peptides with potential as therapeutics.
    [Show full text]
  • Sjitilijse CATTLE Receipts, 6,000; Ehipments, COO
    - - -- - - - " TCr s tTv - s'.'' av Vg.; 25&e WBcMla Bailtj ugle: gtusfflng wcnm'tiijbtv 23, 1888. , . """ hi Kansas CUy Live Stock. E. 11 OONEXHr, M. D. CHHESE COOKERY. AD notices of Employment Situations Wsnua. FOB BENT-liESIDE- Kansas city, Oct. 22. General practitioner of medicine, surgery, gynas-colo- willbecaarsedfortth rate ot t osnts perlias - and obstetrics. Treat all chronic and private BENT Honso of S voonw. good cellar. 5 The Llvo Stock Indicator reports- glTen required. per week: no notice for leas taaa 23 oeata. FOR diseases, oxygen treatment wnea wQl bo well on back porch, with or without Sjitilijse CATTLE Receipts, 6,000; ehipments, COO. Good Plea and all diseases of the rectum a specialty. WICHITA All For Bales or other bneinesa notice bam. at 2S N. Emporia. Call at SH . Emporta. OF A RESTAU- The EAGLE grass range weak, slow and 5c lower; canners and Office removed to 134 North Main street, over Kan- KITCHEN SUPPLIES charted tor at the rata ot 1C cents per line par weelc 1S46S e cow b V 12 a. m.. 1 a ml cows In better demand and steady; good n m sas National Bank. Offlce Hours to to co business notice Tor SO fae 7 8 dur-t- MOTT caien less rMn cent. common; and p. RANT ON STREET. COMMERCE-- . active and steady; ve&x; stcckers and t m. f T?OK RENT A new six room hous for five dollar FINANCE AND feeders slow and weak. Good to cholc corn fed. I- per month in Butler and rWhcr's addition.
    [Show full text]
  • Pain-Causing Venom Peptides: Insights Into Sensory Neuron Pharmacology
    toxins Review Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology Sina Jami 1, Andelain Erickson 2,3, Stuart M. Brierley 2,3 and Irina Vetter 1,4,* ID 1 Institute for Molecular Bioscience, the University of Queensland, St. Lucia, QLD 4072, Australia; [email protected] 2 Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia; [email protected] (A.E.); stuart.brierley@flinders.edu.au (S.M.B.) 3 Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia 5042, Australia 4 School of Pharmacy, The University of Queensland, Woolloongabba, QLD 4103, Australia * Correspondence: [email protected]; Tel.: +61-7-3346-2660 Received: 10 November 2017; Accepted: 20 December 2017; Published: 27 December 2017 Abstract: Venoms are produced by a wide variety of species including spiders, scorpions, reptiles, cnidarians, and fish for the purpose of harming or incapacitating predators or prey. While some venoms are of relatively simple composition, many contain hundreds to thousands of individual components with distinct pharmacological activity. Pain-inducing or “algesic” venom compounds have proven invaluable to our understanding of how physiological nociceptive neural networks operate. In this review, we present an overview of some of the diverse nociceptive pathways that can be modulated by specific venom components to evoke pain. Keywords: animal venom; pain; ASIC; sodium channel; TRP channel; pore forming toxin 1. Venoms and Their Pharmacological Effects Venoms can be defined broadly as toxins secreted by an animal for the purpose of harming or incapacitating predators or prey.
    [Show full text]
  • The Role of Toxins in the Pursuit for Novel Analgesics
    toxins Review The Role of Toxins in the Pursuit for Novel Analgesics Yossi Maatuf †, Matan Geron † and Avi Priel * The Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel; [email protected] (Y.M.); [email protected] (M.G.) * Correspondence: [email protected]; Tel.: +972-2-675-7299 † These authors contributed equally to this work. Received: 24 January 2019; Accepted: 20 February 2019; Published: 23 February 2019 Abstract: Chronic pain is a major medical issue which reduces the quality of life of millions and inflicts a significant burden on health authorities worldwide. Currently, management of chronic pain includes first-line pharmacological therapies that are inadequately effective, as in just a portion of patients pain relief is obtained. Furthermore, most analgesics in use produce severe or intolerable adverse effects that impose dose restrictions and reduce compliance. As the majority of analgesic agents act on the central nervous system (CNS), it is possible that blocking pain at its source by targeting nociceptors would prove more efficient with minimal CNS-related side effects. The development of such analgesics requires the identification of appropriate molecular targets and thorough understanding of their structural and functional features. To this end, plant and animal toxins can be employed as they affect ion channels with high potency and selectivity. Moreover, elucidation of the toxin-bound ion channel structure could generate pharmacophores for rational drug design while favorable safety and analgesic profiles could highlight toxins as leads or even as valuable therapeutic compounds themselves.
    [Show full text]
  • TRPV1 Pore Turret Dictates Distinct Dktx and Capsaicin Gating
    TRPV1 pore turret dictates distinct DkTx and capsaicin gating Matan Gerona,1, Rakesh Kumara,1, Wenchang Zhoub, José D. Faraldo-Gómezb, Valeria Vásquezc,2, and Avi Priela,2 aThe Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Karem, 9112102 Jerusalem, Israel; bTheoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892; and cDepartment of Physiology, The University of Tennessee Health Science Center, Memphis, TN 38163 Edited by Ramon Latorre, Universidad de Valparaíso, Valparaíso, Chile, and approved October 25, 2018 (received for review June 5, 2018) Many neurotoxins inflict pain by targeting receptors expressed on inflammation (22). This toxin has a unique bivalent structure which nociceptors, such as the polymodal cationic channel TRPV1. The consists of two highly homologous inhibitory cysteine knot (ICK) tarantula double-knot toxin (DkTx) is a peptide with an atypical motifs connected by a linker, bestowing the toxin its name (13). bivalent structure, providing it with the unique capability to lock As was shown in the structures obtained by cryo-EM and TRPV1 in its open state and evoke an irreversible channel activation. molecular dynamics simulations of the TRPV1–DkTx/RTX Here, we describe a distinct gating mechanism of DkTx-evoked and TRPV1–DkTx complexes, respectively, the two ICK motifs of TRPV1 activation. Interestingly, DkTx evokes significantly smaller DkTx bind two homologous binding sites in adjacent subunits of TRPV1 macroscopic currents than capsaicin, with a significantly the tetrameric channel, while its linker adopts a taut and con- lower unitary conductance. Accordingly, while capsaicin evokes strained conformation (21, 23, 24).
    [Show full text]
  • Dr. Antônio Guilherme De Souza” Instituto Butantan
    Secretaria de Estado da Saúde de São Paulo Centro de Formação de Recursos Humanos para o SUS/SP “Dr. Antônio Guilherme de Souza” Instituto Butantan RAFAEL DE OLIVEIRA Toxinas animais seletivas a canais iônicos: uma revisão. São Paulo 2020 Rafael de Oliveira Toxinas animais seletivas a canais iônicos: uma revisão. Trabalho de conclusão de curso de especialização apresentado ao Instituto Butantan, unidade do Centro de Formação de Recursos Humanos para o SUS/SP “Doutor Antônio Guilherme de Souza”, como requisito parcial para a obtenção do título de Especialista em Toxinas de Interesse em Saúde. Orientador (a): Dr. Lanfranco Ranieri Paolo Troncone. São Paulo 2020 Oliveira, Rafael de Toxinas animais seletivas a canais iônicos: uma revisão. / Rafael de Oliveira; orientador Lanfranco Ranieri Paolo Troncone. – São Paulo, 2020. 48 f.: il. Trabalho de Conclusão de Curso (Especialização) – Secretaria de Estado da Saúde, Centro de Formação de Recursos Humanos para o SUS/SP “Doutor Antônio Guilherme de Souza” desenvolvido no Instituto Butantan para o Curso de Especialização em Toxinas de Interesse em Saúde. 1. Toxinologia. 2. Canais iônicos. I. Oliveira, Rafael de. II. Instituto Butantan. III. Curso de Especialização em Toxinas de Interesse em Saúde. IV. Título. AGRADECIMENTOS Meus sinceros e eternos agradecimentos: A meu orientador Dr Lanfranco Ranieri Paolo Troncone, pelo tempo, dedicação e aprendizado a mim fornecidos. A Dra Raif Musa Aziz e suas alunas, pela ajuda e disponibilidade. A Janaína Paola Schwerz e seus estagiários, pela aventura neurocientífica. A Aline, Lívia e Rafaela, as muçuranas do serpentário. Ao Pep V, pelas histórias e o ano de 2020. A minha companheira Rita de Cássia, pelas palavras e balas Fini (menos as de amora).
    [Show full text]
  • Animal Toxins Providing Insights Into TRPV1 Activation Mechanism
    toxins Review Animal Toxins Providing Insights into TRPV1 Activation Mechanism Matan Geron †, Adina Hazan † and Avi Priel * ID The Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel; [email protected] (M.G.); [email protected] (A.H.) * Correspondence: [email protected]; Tel.: +972-2-675-7299 † These authors contributed equally to this work. Academic Editor: Steve Peigneur Received: 28 September 2017; Accepted: 13 October 2017; Published: 16 October 2017 Abstract: Beyond providing evolutionary advantages, venoms offer unique research tools, as they were developed to target functionally important proteins and pathways. As a key pain receptor in the nociceptive pathway, transient receptor potential vanilloid 1 (TRPV1) of the TRP superfamily has been shown to be a target for several toxins, as a way of producing pain to deter predators. Importantly, TRPV1 is involved in thermoregulation, inflammation, and acute nociception. As such, toxins provide tools to understand TRPV1 activation and modulation, a critical step in advancing pain research and the development of novel analgesics. Indeed, the phytotoxin capsaicin, which is the spicy chemical in chili peppers, was invaluable in the original cloning and characterization of TRPV1. The unique properties of each subsequently characterized toxin have continued to advance our understanding of functional, structural, and biophysical characteristics of TRPV1. By building on previous reviews, this work aims to provide a comprehensive summary of the advancements made in TRPV1 research in recent years by employing animal toxins, in particular DkTx, RhTx, BmP01, Echis coloratus toxins, APHCs and HCRG21.
    [Show full text]
  • An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
    bioRxiv preprint doi: https://doi.org/10.1101/2020.01.04.894980; this version posted January 6, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 An unorthodox mechanism underlying voltage sensitivity of TRPV1 ion channel 2 Fan Yang1¶,2, Lizhen Xu1, Bo Hyun Lee2, Xian Xiao2,3, Vladimir Yarov-Yarovoy2 and 3 Jie Zheng2¶ 4 1Department of Biophysics and Kidney Disease Center, First Affiliated Hospital, 5 Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, 6 Zhejiang University School of Medicine, Hangzhou 310058, China. 2Department of 7 Physiology and Membrane Biology, University of California, Davis, California 95616, 8 USA. 3Institute for Basic Medical Sciences, Westlake Institute for Advanced Study, 9 Westlake University, Shilongshan Road No. 18, Xihu District, Hangzhou 310064, 10 Zhejiang Province, China. 11 ¶ Correspondence and requests for materials should be addressed to F.Y. (email: 12 [email protected]) or J.Z. (email: [email protected]) 13 14 Abstract 15 While the capsaicin receptor TRPV1 channel is a polymodal nociceptor for heat, 16 capsaicin, and proton, the channel’s responses to each of these stimuli are 17 profoundly regulated by membrane potential, damping or even prohibiting its 18 response at negative voltages and amplifying its response at positive voltages. 19 Though voltage sensitivity plays an important role is shaping pain responses, 20 how voltage regulates TRPV1 activation remains unknown. Here we showed that 21 the voltage sensitivity of TRPV1 does not originate from the S4 segment like 22 classic voltage-gated ion channels; instead, outer pore acidic residues directly 23 partake in voltage-sensitive activation, with their negative charges collectively 24 constituting the observed gating charges.
    [Show full text]