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(12) Patent Application Publication (10) Pub. No.: US 2007/0292530 A1 Dinno (43) Pub

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(12) Patent Application Publication (10) Pub. No.: US 2007/0292530 A1 Dinno (43) Pub US 20070292530A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2007/0292530 A1 Dinno (43) Pub. Date: Dec. 20, 2007 (54) TOPICAL COMPOSITION AND METHOD Publication Classification FOR THE TREATMENT AND PROPHYLAXIS (51) Int. Cl. OF DERMAL RRITATIONS A6IR 33/30 (2006.01) A6IP 7/00 (2006.01) (52) U.S. Cl. .............................................................. 424/642 (76) Inventor: Raied Dinno, Weston, MA (US) (57) ABSTRACT Correspondence Address: A composition and method for the prevention and therapeu tic treatment of skin conditions and disorders are disclosed. WEINGARTEN, SCHURGIN, GAGNEBIN & The composition and method of the invention are particu LEBOVC LLP larly directed to the treatment and prevention of dermal TEN POST OFFICE SQUARE irritations. These irritations include, for example, psoriasis, BOSTON, MA 02109 (US) eczema, ichthyosis, pruritus, dryness and dermatitis, which may cause skin to crack, chap or chafe. The composition and method are particularly useful in treating and preventing (21) Appl. No.: 11/827,369 diaper dermatitis. A therapeutic composition according to the invention includes an agent, which is an enzyme con stituent, promoting the synthesis of collagen and the repro (22) Filed: Jul. 11, 2007 duction of cells, particularly skin cells. Such therapeutic agents include, for example, Zinc oxide. This agent is generally nonprescription and capable of effectively pre Related U.S. Application Data venting and treating diaper dermatitis through local or topical application. Therapeutic compositions according to (63) Continuation of application No. 10/856,740, filed on the invention also include both natural and synthetic com May 28, 2004, now Pat. No. 7.252,846. ponents, which aid in application, use and treatment. US 2007/0292530 A1 Dec. 20, 2007 TOPCAL COMPOSITION AND METHOD FOR and preventing skin conditions and other related dermal THE TREATMENT AND PROPHYLAXIS OF irritations. These conditions and irritations include, for DERMAL RRITATIONS example, psoriasis, eczema, ichthyosis, pruritus, dryness and dermatitis, which may cause skin to crack, chap or chafe. CROSS REFERENCE TO RELATED 0007 Atherapeutic composition according to the inven APPLICATIONS tion includes a therapeutic agent, which is an enzyme 0001. The present application is a continuation applica constituent promoting the synthesis of collagen and the tion of U.S. application Ser. No. 10/856,740, filed May 28, reproduction of cells, particularly skin cells. Such therapeu 2004 and entitled “TOPICAL COMPOSITION AND tic agents include, for example, iron oxide, titanium oxide, METHOD FOR THE TREATMENT AND PROPHY manganese oxide and Zinc oxide. The therapeutic composi LAXIS OF DERMAL IRRITATIONS''. The specification tion is preferably suitable for topical application in a non and contents of U.S. application Ser. No. 10/856,740 are prescription form. When topically applied, the composition incorporated herein by reference in entirety. is effective for treating and preventing diaper dermatitis. The composition may also include an effective combination of BACKGROUND OF THE INVENTION ingredients, such as, for example, those that are organic and synthetic, which aid in application and use as well as 0002 Skin is the largest organ of the human body. In treatment and prevention. general, human skin includes two layers, an outer layer and an underlying layer. The outer layer is known as the epi 0008. In addition, the invention is directed to a method dermis, and the underlying layer is referred to as the dermis. for preparing or compounding the therapeutic composition. The dermis is a connective layer that is responsible for the A method for applying the composition to a dermal area is elasticity of skin. The epidermis primarily functions to also encompassed. Finally, the therapeutic composition is regulate secretion and body temperature, and protect against incorporated with an article of manufacture. This article may dehydration and infection. Skin aliments or disorders, how be a packaging material or a device. ever, tend to retard the functions of the epidermis, and may limit the outer layer's ability to protect the body. Moreover, Definitions skin conditions and dermal irritations are a common prob 0009. The terms “therapeutic composition' or “compo lem for many individuals. sition' generally refer to a composition of the invention. 0003. Although there are numerous skin conditions These terms may refer to any composition suitable for known in the field of dermatology, conditions that normally treating and preventing different skin conditions. Similarly, affect individuals include psoriasis, eczema, dryness and the terms may refer to any form of the composition, such as, dermatitis. One form of dermatitis that is particularly prob for example, an ointment, salve, lotion or cream. lematic and known to reoccur with frequency is diaper 0010) The terms “topical” or “topically” generally refer dermatitis. Diaper dermatitis or diaper rash inflames and to the manner in which the preferred therapeutic composi irritates those dermal parts of the body which are generally tion is applied to the epidermis of the skin. proximate to or covered by a diaper. This inflammation and irritation may cause skin to, for example, crack, chap or 0011. The terms “activity” or “active” generally refer to chafe. the efficacy of an ingredient or composition exhibited during application, particularly topical application. For example, 0004 The pharmaceutical and cosmetics industries are one activity associated with tea tree oil is that it is a natural both concerned with treating diaper rash and its effects. A antiseptic. number of topical products are available to consumers for this purpose. These products include creams, starches and 0012. The terms “effective combination” or “effective powders. amount generally refer to an amount or combination of ingredients useful in promoting at least one specific activity. 0005 Although generally effective to relieve the discom fort associated with diaper dermatitis, the majority of avail For example, an effective amount or quantity of Zinc oxide able topical products do not include nonprescription thera is active in promoting skin cell reproduction. peutic agents for treatment and prevention. Similarly, 0013 The terms “dermal irritation” or “dermal irrita therapeutic agents are not available in products having both tions' generally refer to a skin condition or irritation of the organic and synthetic components, which aid in application epidermis. Such conditions include, for example, psoriasis, and use as well as treatment and prevention. In addition, eczema, dryness and dermatitis, which may cause skin to these products are not effective in treating or preventing crack, chafe, chap, inflame or dry. other related skin conditions. Products are also not available which are easy to apply to different areas of the body. For DETAILED DESCRIPTION OF THE example, a topical talc presents application problems with INVENTION out the use of a carrier that remains in contact with the skin. Finally, the increasing costs of Such products tends to limit 0014. The present invention is effective for treating and preventing a variety of skin conditions. In one embodiment, COSU U.S. the invention is directed to a therapeutic composition includ SUMMARY OF THE INVENTION ing an effective combination for the treatment and preven tion of dermal irritations, particularly diaper dermatitis. The 0006 The present invention is directed to the treatment ingredients of the effective combination each exhibit at least and prophylaxis of skin aliments and disorders. Particularly, one activity, which promotes the treatment and prevention of the disclosed composition and method are useful in treating a skin malady. For example, a moisturizer may be active as US 2007/0292530 A1 Dec. 20, 2007 an emollient as well as a softener of the epidermis. The are understood to be a suitable substitute or supplement for therapeutic composition is also suitable for topical applica the preferred ingredients of the composition, such as, for tion, although other means of application are recognized by example, an antiseptic. those of ordinary skill in the art, Such as, for example, a local 0020. An additional embodiment of the therapeutic com injection. position includes an effective combination of mineral oil, 00.15 Preferably, the therapeutic composition includes an Zinc oxide, quaternium-18 hectorite, magnesium hydrox effective combination of a therapeutic agent, an adhesive ide, cod liver oil, gum karaya powder, propylene carbonate, agent, an emulsifier, an antiseptic, a moisturizer, a buffering tea tree oil, aloe Vera and lanolin. These ingredients may agent, an emollient, a lubricating agent, an anesthetic and a each be present in an amount or quantity effective to treat carrier. An effective combination may require that each and prevent different skin conditions. Similarly, the amount ingredient be present in an amount or quantity Suitable for or quantity of these ingredients may vary depending, for the treatment and prevention of different skin conditions. example, on a specific condition or treatment. The amount or quantity of each ingredient, however, may 0021 According to the invention, an effective combina vary depending on several factors, such as, for example, the tion of ingredients may include about 33% by weight skin condition being treated. mineral oil, about 30% zinc oxide, about 25% quaternium 18 hectorite, about 3.0% magnesium hydroxide,
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