Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 2019 DETERMINATION OF OPTIMAL PARAMETER ESTIMATES FOR MEDICAL INTERVENTIONS IN HUMAN METABOLISM AND INFLAMMATION Marcella Torres Virginia Commonwealth University Follow this and additional works at: https://scholarscompass.vcu.edu/etd Part of the Other Applied Mathematics Commons, and the Systems Biology Commons © The Author Downloaded from https://scholarscompass.vcu.edu/etd/5890 This Dissertation is brought to you for free and open access by the Graduate School at VCU Scholars Compass. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of VCU Scholars Compass. For more information, please contact
[email protected]. ©Marcella Maria Torres, May 2019 All Rights Reserved. i DETERMINATION OF OPTIMAL PARAMETER ESTIMATES FOR MEDICAL INTERVENTIONS IN HUMAN METABOLISM AND INFLAMMATION A Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. by MARCELLA MARIA TORRES M.S. Applied Mathematics, Virginia Commonwealth University, 2015 B.S. Mathematical Sciences, Minor in Physics, Virginia Commonwealth University, 2007 Director: Angela Reynolds, Associate Professor, Department of Mathematics and Applied Mathematics Virginia Commonwewalth University Richmond, Virginia May, 2019 ii Acknowledgements I am extremely grateful to my advisor, Dr. Angela Reynolds. Thank you for supporting my random walk over the applied mathematics landscape. Also, thank you - from one mother to another - for understanding my at times high level of distraction. Especially for missing the start of that one meeting that one time. I am also deeply indebted to Dr. Rebecca Segal for being a great collaborator and mentor.