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Carcinogens, Mutagens and Substances Toxic to Reproduction in Groups/Categories 1 and 2

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Carcinogens, Mutagens and Substances Toxic to Reproduction in Groups/Categories 1 and 2 Code of Practice March 2009 Review every 2 years Carcinogens, Mutagens and Substances Toxic to Reproduction In Groups/Categories 1 and 2 Health and Safety Office HSD021C Table of Carcinogens, Mutagens and Substances Toxic to Reproduction, in Groups or Categories 1 and 2. Notes to the Table This list of carcinogens, mutagens and substances toxic to reproduction has been compiled and consolidated from the following sources: The lists from IARC, groups 1 (carcinogenic to humans), 2A (probably carcinogenic to humans). The carcinogen lists in EH40, 2002, which is published by the HSE The lists of carcinogens, mutagens and substances toxic to reproduction in The Dangerous Substances and Preparations (Safety) (Consolidation), as amended in 2004 SI 1417, and Chemicals (Hazard Information and Packaging for Supply) (Amendment) Regulations 2000, SI 2897 (known as CHIP Regulations) The Control of Substances Hazardous to Health 2002 and amendment 2003. The Approved Supply List, 2002.L129, published by the HSE. Information supplied by manufacturers. Where a substance is classified as Group 2 or Category 2 it is denoted by a tick in the table. For these substances the link to the health effect is probable. Where a substance is in Group or Category 1, the link between the substance and the health effect is proven, and the table entry is ‘Cat. 1’. Where one information source lists a substance as Category 1, and another as Category 2, the higher classification is listed here. Risk or ‘R’ phrases and Safety or ‘S’ phrases are assigned to a substance in compliance with the CHIP Regulations to promote a uniform standard of labelling for users. ‘R’ phrases indicate the risks inherent in the substance, and include risks to health, the environment and in relation to fire and explosion. ‘S’ phrases indicate the precautions to be taken in using and handling the substance or preparation. The key to the meaning of the ‘R’ and ‘S’ phrases is on the following pages. Note that these are correct as at October 2003 (CHIP3) and there have been some recent changes in wording, specifically for R40 and R68. These changes will be phased-in on MSDS’s, and for some time there will be ‘old’ and ‘new’ sheets co-existing in the workplace. It is therefore essential to read the MSDS carefully to gain the precise meaning of the ‘R’ phrase being used. Be particularly aware that not all hazardous substances that may be encountered at work will be classified in this way. In particular those that arise within the workplace, such as moulds, welding fume, intermediates in synthesis, etc will need to be assessed by yourselves. The ‘R’ and ‘S’ phrase information is derived from several sources, and it must be borne in mind that there is frequently a time lag between a substance appearing on a list of carcinogens, etc, and the dissemination of the new ‘R’ and ‘S’ phrases. Therefore the absence of the ‘R’ phrase that indicates carcinogen, mutagen, etc is due to this time lag. This information is given as a supplement to your own research, not as a substitute in any way for the gathering and scrutiny of the manufacturer’s data sheets. Wherever possible synonyms for compounds have been included. Carcinogens, Mutagens and Substances Toxic to Reproduction March 2009 Risk Phrases R1 Explosive when dry R23 Toxic by inhalation Risk of explosion by shock, friction, fire or other sources of R23/24 Toxic by inhalation and in contact with skin R2 ignition R23/24/25 Toxic by inhalation, in contact with skin and if swallowed Extreme risk of explosion by shock, friction, fire or other R3 R23/25 Toxic by inhalation and if swallowed sources of ignition R24 Toxic in contact with skin R4 Forms very sensitive explosive metallic compounds R24/25 Toxic in contact with skin and if swallowed R5 Heating may cause an explosion R25 Toxic if swallowed R6 Explosive with or without contact with air R26 Very toxic by inhalation R7 May cause fire R26/27 Very toxic by inhalation and in contact with skin R8 Contact with combustible material may cause fire Very toxic by inhalation, in contact with skin and if R26/27/28 R9 Explosive when mixed with combustible material swallowed R10 Flammable R26/28 Very toxic by inhalation and if swallowed R11 Highly flammable R27 Very toxic in contact with skin R12 Extremely flammable R27/28 Very toxic in contact with skin and if swallowed R14 Reacts violently with water R28 Very toxic if swallowed Reacts violently with water, liberating extremely flammable R14/15 R30 Can become highly flammable in use gases R31 Contact with acids liberates toxic gas R15 Contact with water liberates extremely flammable gases R32 Contact with acids liberates very toxic gas Contact with water liberates toxic, extremely flammable R15/29 R33 Danger of cumulative effects gases R34 Causes burns R16 Explosive when mixed with oxidising substances R35 Causes severe burns R17 Spontaneously flammable in air R36 Irritating to eyes R18 In use, may form flammable/explosive vapour-air mixture R36/37 Irritating to eyes and respiratory system R19 May form explosive peroxides R36/37/38 Irritating to eyes, respiratory system and skin R20 Harmful by inhalation R36/38 Irritating to eyes and skin R20/21 Harmful by inhalation and in contact with skin R37 Irritating to respiratory system R20/21/22 Harmful by inhalation, in contact with skin and if swallowed R37/38 Irritating to respiratory system and skin R20/22 Harmful by inhalation and if swallowed R38 Irritating to skin R21 Harmful in contact with skin R39 Danger of very serious irreversible effects R21/22 Harmful in contact with skin and if swallowed Toxic: danger of very serious irreversible effects through R39/23 R22 Harmful if swallowed inhalation Carcinogens, Mutagens and Substances Toxic to Reproduction March 2009 Risk Phrases, continued R39/23/24 Toxic: danger of very serious irreversible effects through R45 May cause cancer inhalation and in contact with skin R46 May cause heritable genetic damage R39/23/24/25 Toxic: danger of very serious irreversible effects through R48 Danger of serious damage to health by prolonged exposure inhalation, in contact with skin and if swallowed Harmful: danger of serious damage to health by prolonged Toxic: danger of very serious irreversible effects through R48/20 R39/23/25 exposure through inhalation inhalation and if swallowed R48/20/21 Harmful: danger of serious damage to health by prolonged Toxic: danger of very serious irreversible effects in contact R39/24 exposure through inhalation and in contact with skin with skin R48/20/21/22 Harmful: danger of serious damage to health by prolonged Toxic: danger of very serious irreversible effects in contact R39/24/25 exposure through inhalation, in contact with skin and if with skin and if swallowed swallowed Toxic: danger of very serious irreversible effects if R39/25 R48/20/22 Harmful: danger of serious damage to health by prolonged swallowed exposure through inhalation and if swallowed Very Toxic: danger of very serious irreversible effects R39/26 R48/21 Harmful: danger of serious damage to health by prolonged through inhalation exposure in contact with skin R39/26/27 Very Toxic: danger of very serious irreversible effects R48/21/22 Harmful: danger of serious damage to health by prolonged through inhalation and in contact with skin exposure in contact with skin and if swallowed R39/26/27/28 Very Toxic: danger of very serious irreversible effects Harmful: danger of serious damage to health by prolonged R48/22 through inhalation, in contact with skin and if swallowed exposure if swallowed R39/26/28 Very Toxic: danger of very serious irreversible effects Toxic: danger of serious damage to health by prolonged R48/23 through inhalation and if swallowed exposure through inhalation Very Toxic: danger of very serious irreversible effects in R39/27 R48/23/24 Toxic: danger of serious damage to health by prolonged contact with skin exposure through inhalation and in contact with skin R39/27/28 Very Toxic: danger of very serious irreversible effects in Toxic: danger of serious damage to health by prolonged contact with skin and if swallowed R48/23/24/25 exposure through inhalation, in contact with skin and if Very Toxic: danger of very serious irreversible effects if swallowed R39/28 swallowed R48/23/25 Toxic: danger of serious damage to health by prolonged R40 Limited evidence of a carcinogenic effect exposure through inhalation and if swallowed R41 Risk of serious damage to eyes Toxic: danger of serious damage to health by prolonged R48/24 R42 May cause sensitisation by inhalation exposure in contact with skin R43 May cause sensitisation by skin contact R48/24/25 Toxic: danger of serious damage to health by prolonged R42/43 May cause sensitisation by inhalation and skin contact exposure in contact with skin and if swallowed R44 Risk of explosion if heated under confinement Carcinogens, Mutagens and Substances Toxic to Reproduction March 2009 Risk Phrases, continued Toxic: danger of serious damage to health by prolonged R61 May cause harm to the unborn child R48/25 exposure if swallowed R62 Possible risk of impaired fertility R49 May cause cancer by inhalation R63 Possible risk of harm to the unborn child R50 Very toxic to aquatic organisms R64 May cause harm to breast-fed babies R50/53 Very toxic to aquatic organisms, may cause long-term R65 Harmful: may cause lung damage if swallowed adverse effects in the aquatic environment R66 Repeated exposure may cause skin dryness or cracking R51 Toxic to aquatic organisms R67 Vapours may cause drowsiness and dizziness R51/53 Toxic to aquatic
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