Boston University College and Graduate School of Arts & Sciences Undergraduate Academic Program Office 725 Commonwealth Avenue, Room 102 CAS/GRS Course Revision Proposal Form To be used only for proposing a revision of a CAS course without BU Hub credit as well as for all GRS courses. This completed form and all required documents should be submitted as PDF files to either Sr. Academic Administrator Peter Law [email protected] (for CAS and CAS/GRS “piggyback” courses) or to Graduate Services Associate Casey Dziuba [email protected] (for GRS-only courses). Please contact them for information or assistance, if necessary. DEPARTMENT OR PROGRAM: Chemistry DATE SUBMITTED: 9/18/18 CURRENT COURSE NUMBER (include college code—CAS or GRS): CH 541 CURRENT COURSE NAME: Natural Products Chemistry CURRENT 40 WORD COURSE DESCRIPTION: Chemical and biosynthetic pathways leading to important natural products derived from fatty acids, terpenes, amino acids, polyketides, shikimic acid, and other biosynthetic intermediates. Three hours lecture, one hour discussion. CURRENT CROSS-LISTING DEPARTMENT/PROGRAM, if any: NA TO BE OFFERED NEXT: Sem./Year: _Fall___ /___2019_ INSTRUCTOR(S): Pinghua Liu ITEMS PROPOSED FOR REVISION (check all that apply): XX Course Number ! Credits ! Prerequisites ! Title ! Cross-listing ! Corequisites ! Short Title ! 40 Word Description ! Other (Explain) PROPOSED REVISIONS: For each item checked above, provide the current information, then the proposed information, then a brief explanation for the proposed change, including the intended impact of the change. 1. [First item checked] a. Current information: CH 541 b. Proposed information: CH 624 c. Explanation & impact: The current course number (CH 541) is out of date. This course was originally proposed in 1983 when the 500-level designation was intended to represent a course suitable for beginning graduate students and upper level undergraduate students. The intended audience is still graduate students and advanced, undergraduate seniors, with the rigor of the class adjusted appropriately for these students. The problem corrected by this change is that a 500-level course does not appear in the GRS listings, only under CAS. Our senior majors have no trouble finding a GRS- listed course – they register for 600- and 700-level courses routinely. Incoming graduate students, 1 however, often miss a course if it does not appear under GRS, so this numbering correction is long overdue. The intensity level and rigor of this class matches that of our other 600-level graduate courses. 2. [Second item checked] a. Current information: b. Proposed information: c. Explanation & impact: etc… IMPACT ON OTHER DEPARTMENTS/PROGRAMS: Will any of these changes have an impact on students pursuing the degree requirements or expectations of other departments, programs, or schools? Check one: XX Yes ! No If YES, please identify impacts and attach cognate comment from the appropriate department/ program/ school. We are frequently contacted by BMB faculty as to suitable graduate courses for their majors. We will make them aware of the numbering change. RESOURCE NEEDS: STAFFING, FACILITIES, AND EQUIPMENT: As a result of the proposed changes, will there be any changes in the staffing, special facilities or equipment needs of the course (e.g. laboratory, library, instructional technology, technical resources, etc)? Check one: ! Yes XX No If YES, explain further and indicate whether currently available staffing, facilities, and equipment are adequate for the proposed course. (NOTE: Approval of proposed revisions does not imply a change in resource commitments on the part of CAS.) ADDITIONAL DOCUMENTS THAT MUST BE SUBMITTED IN ORDER FOR THIS PROPOSAL TO BE CONSIDERED: • A complete week-by-week SYLLABUS with student learning objectives, readings, and assignments that reflects the specifications of the course described in this proposal; that is, appropriate level, credits, etc. (See guidelines on “Writing a Syllabus” on the Center for Teaching & Learning website.) A typical, effective syllabus template is provided here under “Curriculum Review & Modification”. • Be sure that syllabus includes your expectations for academic honesty, with URL for pertinent undergraduate or GRS academic conduct code(s). • Cognate comment from chairs or directors of relevant departments and/or programs. Use the form here under “Curriculum Review & Modification.” You can consult with Dean Joseph Bizup (CAS) at [email protected] or Dean Emily Barman (GRS) at [email protected] to determine which departments or programs inside and outside of CAS/GRS would be appropriate. 2 DEPARTMENT CONTACT NAME & POSITION: John K. Snyder PROFESSOR OF CHEMISTRY, ASSOCIATE CHAIR DEPARTMENT CONTACT EMAIL & PHONE: [email protected] 353-2621 Signature(s) required: 9/18/18 DEPARTMENT APPROVAL: Department Chair Date Other Department Chair(s) (required for cross-listed courses) Date revised 10/11/2017 3 Boston University College and Graduate School of Arts & Sciences 725 Commonwealth Avenue, Room 106, Boston, MA 02215 T: 617-353-2401 Date: 7/25/2018 Cognate Comment Request TO: Name: John Celenza Department: Program in Biochemistry and Molecular Biology FROM: Name: John Snyder ` Department: Chemistry Telephone: 3-8663 E-mail [email protected] Course Number: CH 541, change to CH 624 __ Course or Program Title: ______Natural Products Chemistry Our Department would like to request cognate comments on this course (or program). A complete proposal is attached for your review. If you need further information, please do not hesitate to contact me. Kindly return the signed original to me by _8/15/2018_ so that I may include your comments when submitting our proposal for review and approval. Please do not send any cognate letters directly to the dean’s office. Thank you. COMMENTS: The BMB Program has no issues with this proposed course number change. Please explain fully any objections. Signature: Date: August 1, 2018 Title: Director, Program in Biochemistry and Molecular Biology CH 624 (Fall 2018) Nature Product Chemistry Tue., Thur. 12:30 – 1:45 PM SOC B61 http://learn.bu.edu The log in with your BU account and password INSTRUCTOR: Prof. Pinghua Liu OFFICE: Sci. Rm 453 (617) 353-2481 [email protected] OFFICE HOURS: Tue, Thur 2:00 – 3:00 PM or by appointment TEXTBOOK: 1. Comprehensive Natural Products (2nd edition) 2. Materials to be distributed in the class. 3. Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery READING MATERIALS will be provided at the beginning of each topic. Papers from recent literature regarding the application of knowledge in both basic research and medical application will be given in class. GOALS: The goal is to provide you with an overview on the biosynthetic knowledge of major types of natural products, the state-of- art tools of natural product biosynthetic studies, and the application of natural products in medicine and as tools in studying biological processes (chemical biology). Some real-life examples (e.g., humane medicine, beer flavor, chemistry of tea/coffee, wine, and toxin) will also be covered to give some real life examples. EVALUATION: Problem sets. These will contribute 15% to your final mark; but they MUST be done in order to receive credit for the course. The problem sets are intended to help you understand the papers in the discussed scientific area. Exams. We will have two mid-term exams (Date Oct. 18th, and Final). It will account for 70% of your final mark. Exam room will be announced later. Final paper presentation (Final exam). It will account for 15% of your final mark. You will be given a paper, which is related to one of the topics covered in the class. In one week, you will give a presentation on that topic and be challenged by both the instructor and other students in the class. ACADEMIC POLICIES This course follows the Boston University guidelines for academic conduct including policies on cheating and plagiarism. It is the responsibility of each student to know and understand the provisions of the Academic Conduct Code. Graduate student academic conduct code (GRS): http://www.bu.edu/grs/academics/resources/adp.html Undergraduate academic conduct code (CAS): http://www.bu.edu/cas/academics/programs/conductcode.html 1 TOPICS (Tentative Schedule) I. Introduction: The role of synthesis and biosynthetic logic (II, 559) Basics of cellular primary metabolisms Amino acids, nucleotides, and central dogma Primary metabolism: sugar, fatty acids, TCA cycle Structure determinations: Miassigned structures: Case Examples from the past (II, 581) HPLC (IX, 5) NMR (IX, 169, 279) MS (IX, 389, 457) Bioinformatics (IX, 569) II. PKS Basic principles: Class I Class II Class III Iterative III. Terpenoids (MVA, MEP, modified, and MTA shunt); Isoprenoids in actinomyces and their biosynthesis; Practical example: carotenoids and taxol/artemisinin IV. Shikimate pathway Shikimate pathway Flavonoids V. Amino Acids, Peptides, and Proteins Non-protein amino acids (V, 5) Lantibiotics (V, 217) NRPS (V, 619) Protein post-translational modifications (V, 433) Alkaloids: Basic building blocks from amino acids: Terpene alkaloids: (plants and fungi) Practical examples: Beer Flavor Chemistry of Coffee Chemistry of Wine VI. Sugar and nucleotides Glycosyltransferase and glycosideases: Enzymatic synthesis of complex carbohydrates (VI, 5) Deoxysugars Aminoglycosides Biosynthesis Or Deoxysugars Nucleoside analogs (VI, 663) RNA modifying Enzymes VII. Chemical Ecology Bacteriocins Chemical defense and toxins of plants (IV, 339) Toxins of Microorganisms (IV,