molecules Article Potent in Vitro α-Glucosidase Inhibition of Secondary Metabolites Derived from Dryopteris cycadina Surriya Amin 1, Barkat Ullah 1, Mumtaz Ali 2, Abdur Rauf 3 , Haroon Khan 4,* , Eugenio Uriarte 5,6 and Eduardo Sobarzo-Sánchez 7,8,* 1 Department of Botany, Islamia College University, Peshawar 25000, Pakistan;
[email protected] (S.A.);
[email protected] (B.U.) 2 Department of Chemistry, University of Malakand, Upper Dir 23050, Pakistan;
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[email protected] 4 Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan 5 Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, Santiago 7500912, Chile;
[email protected] 6 Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain 7 Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago 8330507, Chile 8 Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain * Correspondence:
[email protected] (H.K.);
[email protected] (E.S.-S.); Tel.+92-3329123171 (H.K.) Received: 30 November 2018; Accepted: 21 January 2019; Published: 24 January 2019 Abstract: α-glucosidase is responsible for the hydrolysis of complex carbohydrates into simple absorbable glucose and causes postprandial hyperglycemia. α-glucosidase inhibition is thus the ideal target to prevent postprandial hyperglycemia. The present study was therefore designed to analyze the effects of various compounds isolated from Dryopteris cycadina against α-glucosidase including β-Sitosterol 1, β-Sitosterol3-O-β-D-glucopyranoside 2, 3, 5, 7-trihydroxy-2-(p-tolyl) chorman-4-one 3, Quercetin-3-0-β-D-glucopyranoside (3/!0-3///)- β-D- Quercetin -3-0- β –D-galactopyranoside 4 and 5, 7, 4/-Trihydroxyflavon-3-glucopyranoid 5.