Department of Molecular & Integrative Physiology

Annual Report of the

Department of Molecular & Integrative Physiology University of Kansas Medical Center

July 1, 2017 – June 30, 2018

TABLE OF CONTENTS

Year in Review…………………………………………………………… 1

Department Chairs……………………………………………………….. 8

Emeritus Professors……………………………………………………... 9

Donors…………………………………………………………………….. 10

Faculty.……………………………………………………………………. 20

Graduate Students………………………………………………………. 21

Department Roster………………………………………………………. 22

Graduate Student Activities…..……….………………………………… 28

Courses Taught….……………………………………………………..... 33

Department Seminars….………………………………………………... 35

Publications

a. Published (7/1/17 – 6/30/18)………………………………... 46

b. In Press……………………………………………………….. 52

c. Abstracts…..………………………………………………….. 54

Research Support……..…………………………………………………. 57

Faculty Activities…………………………………………………………. 61

YEAR IN REVIEW 2017 – 2018

The Department of Molecular and Integrative Physiology continues under the leadership of Dr. V. Gustavo Blanco, who serves as the Kathleen M. Osborn Chair and Dr. Warren Nothnick, who is the Vice Chair. The department maintains a relatively large size, currently having 16 tenured faculty members, 3 research track faculty, 3 postdoctoral fellows, 3 senior scientists, and 17 doctoral graduate students. In May of 2018, a new faculty member, Dr. Ning Wang, joined our department as an assistant professor. Dr. Wang came from Harvard University and with his work in male reproduction, he represents a great addition to our group of reproductive researchers.

During this past year the physiology department has successfully continued working towards its academic goals, which include: 1) engaging in high quality research to generate new discoveries of physiological relevance in basic and translational science that contribute to advance human health; 2) training new generations of physicians, graduate students, and postdoctoral fellows in physiology and pathophysiology through high quality and innovative teaching, to contribute to the academic excellence of KUMC and 3) providing academic service through participation in different committees and task forces that help the functioning of our department and school.

Research programs in the department span various areas of research and the investigators have continued to maintain a consistent level of publications. This past year approximately 60 peer reviewed original articles were published in top research journals and as book chapters. The main research areas of the department include male and female reproduction, neuroscience, muscle, metabolism and integrative physiology. Studies are performed at the molecular and whole animal level and utilize a wide diversity of methods and approaches. In addition, research in the department complements the research efforts of several centers in our institution.

Regarding teaching, the department has had another outstanding year. Our faculty continued to maintain a high presence in medical education during the first and second year of the Active Competency based and Excellence driven (ACE) curriculum. Dr. Wood served as Discipline Leader, and he and Dr. Stanford lead the Cardiopulmonary and Muscle and Movement blocks respectively as Module Directors. Dr. Wolfe has been working on the upcoming Reproductive block. All our faculty were involved as Facilitators, leading the small group Case Based Clinical Learning (CBCL) activities of the ACE medical curriculum. The hard work of our faculty in teaching has been recognized with important awards given to individual lecturers and to course directors for their excellence in education. Members of our department have also continued to play a major role in the education of graduate students by participating in the core Integrated Graduate Program in Biological Sciences (IGPBS) curriculum. Faculty also taught in our department’s mandatory courses for graduate students, including the Comprehensive Human Physiology and Human Pathophysiology courses, led by Drs. Andrei Belousov and Steve LeVine respectively. In addition, various advanced physiology courses were offered, which cover new advances in specific areas of physiology. As a testament to the work of our faculty these courses have received 1 excellent reviews from the students. Moreover, several of our faculty were invited to give educational seminars at other universities; Drs. Blanco and Christenson taught lectures and a laboratory in the prestigious Frontiers in Reproduction international course offered every year at the Marine Biological Laboratories in Woods Hole, Massachusetts.

We are also proud that members of the physiology department have continued serving in numerous key committees and leadership roles at the university level which are essential to the overall mission of our school. Dr. Smith serves as the Senior Associate Dean for Research and the Co-Director of the Kansas Intellectual and Developmental Disabilities Research Center (KIDDRC); Dr. Nothnick is the Director of the Center for Reproductive Sciences; Dr. Stanford is the Program Director of the KUMC Biomedical Research Training Program and the Campus Coordinator, K-INBRE Program Director; Dr. Blanco is the K-INBRE Research Developmental Core Director; Dr. Geiger is the Facility Co- Director of the Metabolic and Obesity Research Phenotyping Facility (MORPh); Dr. Thyfault is the Scientific Director of Children’s Mercy Healthy Lifestyle and Nutrition Center (KUMC/CMH joint funded center), and Dr. Wolfe is the Research Integrity Officer of our school. In addition, we have maintained our presence at the national and international level. Our faculty have served on different review panels of the National Institutes of Health as well as review panels of other funding agencies. They have also participated as editors, or as members of the editorial boards for a variety of journals. We are very grateful to our faculty who through talent and hard work, have continued to maintain the high academic standards and success that gives our department great national and international visibility.

The physiology department has also undergone some challenges this year. This consisted in difficulties related to obtaining extramural funding, which is a problem common to other departments and schools. This has been caused by the continuous reduction in funding from local and national agencies. Funding was further impacted by some changes in the allocation model for the distribution of funds in our university, which occurred at the beginning of 2018. The department has taken initiatives, by starting an enhancement program, with the idea of facilitating faculty obtaining grants. We are confident that this should improve our ability to obtain new funds.

Regarding the department’s office, we continue operating with Shari Standiferd, who serves as the Director of Operations, and Jennifer Wallace and Liam Higgins, who are our coordinators for financial accounting support. Our special thanks go to them. They provide outstanding administrative support to our department through their hard work and continuous dedication. In addition, we would like to thank our work study students, Alexis Battershell and Mackenzie Boone, who provided additional excellent clerical support to our office.

We would like to especially recognize our benefactor and continuous supporter Mr. Jim Osborn. His generous contributions over the years, in memorial of his daughter Kathleen, and wife Marion, as well as his recent commitment have significantly contributed to our success. The Kathleen M. Osborn Endowed Chair, the Marion M.

Osborn Professorship, and the lectureship in honor of Kathleen M. Osborn have made a great difference to our department. These funds continue to support the department’s goals and our students. We all immensely appreciate the exceptional support that Jim Osborn has given in honor of his family.

HIGHLIGHTS FROM THE 2017 – 2018 ACADEMIC YEAR

RESEARCH FUNDING: The loss of faculty, as well as the difficulties in obtaining new grants, has resulted in a decrease in research funding to the department. Most universities today face a climate of low general funding levels. Currently members of our department continue to work hard to produce and submit high quality grant proposals. This has resulted in new grants being funded; however, our goal is to increase this number. Based on data provided by KUMC Enterprise Analytics, total NIH funding was $3,184,810, which is higher than that of last year ($2,571,231). The latest data available shows that our department was ranked 52nd at the national level for NIH research funding among 81 medical schools receiving NIH funding. While this is a good position, we would like to improve this ranking. During fiscal year 2018 grant requests from the department indicated total costs of $47,599,374 (which included $34,479,119 in direct costs and $13,120,255 in indirect costs). From these, $44,936,433 corresponded to grant proposals submitted to the National Institutes of Health.

EDUCATION: Continuing a long tradition the physiology department has had another outstanding year with respect to teaching. As mentioned previously, Drs. John Wood and Stanford led the Cardiopulmonary and Muscle and Movement blocks of the ACE curriculum. Cardiopulmonary was awarded best module and Drs. Blanco and Wood received Student Voice awards for excellence in teaching. These awards were presented by the medical students at the Grande Affair celebration on January 20, 2018. These awards are a testimony to the long-lasting commitment of our faculty members to education. As a continuation of our commitment to education, our faculty participated in developing the new ACE medical curriculum. Dr. John Wood served as a Discipline Leader. Due to the importance of physiology in years 1 and 2 of the medical curriculum, faculty in our department will continue to have an important role in teaching new generations of physicians. Regarding the graduate student curriculum, we continued offering our two main courses, Human Physiology and Human Pathophysiology, directed by Drs. Belousov and LeVine respectively. In addition, several advanced courses were taught. These included the Integrative Physiology of Exercise course (directed by Drs. Geiger and Thyfault) and the Molecular Mechanisms of Neurological Disorders (lead by Dr. LeVine).

TENURE TRACK APPOINTMENTS: We are pleased and excited to have added Dr. Ning Wang to the department as a new assistant professor.

Ning Wang, Ph.D., started as an assistant professor on May 1, 2018. His research focuses on the study of male germ cell development and the molecular mechanisms involved in meiosis during spermatogenesis.

RESEARCH TRACK APPOINTMENTS: No new appointments occurred this fiscal year.

JOINT AND ADJUNCT APPOINTMENTS: No new appointments this fiscal year.

FACULTY PROMOTIONS: Dr. Lane Christenson was promoted to full professor with tenure starting July 1, 2018. Dr. Christenson’s work focuses on ovarian function and microRNA-vesicle meditated (exosome) cellular communication.

Dr. Paige Geiger was promoted to full professor with tenure starting July 1, 2018. Dr. Geiger’s work focuses on muscle physiology and the effects of exercise, diet and hormonal levels on muscle metabolism and insulin resistance, type II diabetes.

Dr. Phil Lee was promoted to full professor with tenure starting July 1, 2018. Dr. Lee’s work focuses on neurophysiology and neuroimaging, specifically on the characterization of functional and physiological processes of the brain in vivo in health and disease, using advanced non-invasive neuroimaging techniques.

Dr. John Stanford was promoted to full professor with tenure starting July 1, 2018. Dr. Stanford’s work focuses on motor function in neurological disorders across the lifespan.

Dr. John Thyfault was promoted to full professor with tenure starting July 1, 2018. Dr. Thyfault’s work focuses on chronic physical inactivity, sedentary behavior, and low aerobic fitness and their relationship to the development of chronic disease conditions (obesity, insulin resistance, fatty liver disease, type 2 diabetes, and cardiovascular disease).

FACULTY/STAFF DEPARTURES: Joseph S. Tash, Ph.D. finished his phased retirement period and fully retired on January 14, 2018. He was recruited to KUMC on June 24, 1990. Dr. Tash was named Emeritus Professor on January 15, 2018 and we wish him the best retirement after 27 years of dedicated service as Professor of Physiology.

FACULTY AWARDS/ACCOMPLISHMENTS: Numerous members of our department have been serving on review panels from NIH and other agencies. They have also served as editors or on the editorial board of different journals and presented invited lectures at different national and international meetings and seminars at other universities.

GRADUATE PROGRAM AND PHYSIOLOGY SOCIETY: The student led “Physiology Society” continued functioning well this year. A new president was elected and a new committee was chosen. The leadership of the Physiology Society is currently:

Zahraa Alali, President Younshim Park, Vice-President/Stowers Chair Joshua Curry, Social Chair

The graduate students in the department had another active year. In 2017-2018 eight new students were recruited to the department. These include students who are working with our affiliate members at Stowers Research Institute and joint appointment faculty at KUMC. Currently, our department has a total of 17 enrolled doctoral students. Several of our students were awarded external fellowships to support their training. Funding came

from different sources, including the SELF Fellowship program, the KUMC Biomedical Training Program, National Science Foundation, and National Institute of Health.

The new graduate students that joined the department in the 2017-2018 fiscal year included the following individuals (their respective mentors are listed in parenthesis):

Fatimah Aljubran (Dr. Vargheese Chennathukuzhi) Ashley Cloud (Dr. Vargheese Chennathukuzhi) Page Hayley (Dr. Randolph Nudo) Rikki Nelson (Dr. Lane Christenson) Diego Paez-Moscoso (Dr. Peter Baumann) Consuelo Perez Sanchez (Dr. Kausik Si) Elizabeth Thoenen (Dr. Tomoo Iwakuma) Alex Von Schulze (Drs. Paige Geiger/John Thyfault)

Four students completed their Ph.D. degrees during the summer of 2017. Congratulations to all of them and their mentors.

Summer 2017 Fall 2017 Spring 2018 †Amy Cantilena, Ph.D. No Graduates for Fall No Graduates for Spring Liying Li, Ph.D. Margaret Pruitt, Ph.D. Archana Raman, Ph.D.

†Amy Cantilena, Ph.D. (May 8, 2017) received her degree with Dr. Buddhadeb Dawn in the Cardiovascular Department. The title of her dissertation was “The Role of Endoglin in the Immunomodulatory Capacities of Mesenchymal Stem Cells and the Relationship to Hyperbaric Oxygen Therapy”.

Margaret Pruitt, Ph.D. (May 11, 2017) received her degree with Dr. Peter Baumann at the Stowers Institute. The title of her dissertation was “Interrogating Telomerase Activity and Telomere Function through In-Flask Template Evolution”. Dr. Pruitt is now a M.D. student in her third year of clerkship at KU Medical Center.

Archana Raman, Ph.D. (June 12, 2017) received her degree with Dr. Darren Wallace in the Kidney Institute. The title of her dissertation was “The Role of Matricellular Signaling in Polycystic Kidney Disease”. Dr. Raman continued as a Postdoctoral Fellow in the Kidney Institute at KU Medical Center.

Liying Li, Ph.D. (June 22, 2017) received her degree with Dr. Kausik Si at the Stowers Institute. The title of her dissertation was “Drosophila CPEB, Orb2, a Putative Biochemical Engram of Long-term Memory”. Dr. Li. is a Postdoctoral research associate at the University of California San Francisco.

Prepared by:

V. Gustavo Blanco, M.D./Ph.D. Professor and Kathleen M. Osborn Chair

Molecular & Integrative Physiology Emeritus Professors

In Honor of Physiology Donors and the Continued Impact that their Generosity Provides

Mr. James Osborn (1919 – 2018)

Mr. Osborn’s relationship with our department began through his daughter Kathleen. She developed an interest in science and biology in high school and while attending college at the University of Missouri. During the summers of 1968 and 1969, Kathleen worked in the reproductive physiology lab of Dr. Gilbert Greenwald at the KU School of Medicine. This experience was particularly meaningful to Kathleen and might have motivated her to enter a career in science had she not been taken prematurely in an automobile accident in 1970. At the time of her death, Kathleen was in her junior year at the University of Missouri.

Mr. Osborn and his late wife Marion, had such high regard for Dr. Greenwald, who died in 2004, and deep gratitude for Kathleen’s experience, that they made plans to benefit the medical center through KU Endowment. Their generosity started with the Kathleen M. Osborn Lectureship in 1971. This lectureship remains the longest running and most successful lectureship in the history of the medical center. It has attracted a long list of preeminent scientists from around the world and funds from the Kathleen Osborn Lectureship have also supported the annual Gilbert S. Greenwald Symposium.

In 2006, in memory of his beloved wife, Mr. Osborn established the Marion M. Osborn Professorship to support reproductive science within the department. The inaugural and current recipient is Dr. Leslie Heckert.

Mr. Osborn continued his generosity in honor of his daughter in 2012, establishing the Kathleen M. Osborn Chair to support the leadership position of the department. Dr. Paul Cheney was the inaugural recipient and in 2016 Dr. Gustavo Blanco was named the second Kathleen M. Osborn Chair.

This year we are again the thankful beneficiaries of Mr. Osborn’s philanthropy with the establishment of the Kathleen M. Osborn Fellowship in Reproductive Physiology. This fellowship will support graduate students in our department interested particularly in reproductive science. The fellowship will enable recipient students to discover the same

10 enthusiasm for science and love of learning that Kathleen found so many years ago. The first student to receive this great honor was Rikki Nelson.

William Biklen Pendleton J.D. (1920 – 2015)

William Biklen Pendleton attended Liberty High School and graduated in 1939 from Shattuck High School in Minnesota. After graduation he attended the University of Kansas and joined the Beta Theta Pi fraternity. William served during World War II in the U.S. Army from 1942- 1946 as a Lieutenant in the 593rd engineer boat and shore regiment that was attached to the Australian 6th Division for the invasion of Borneo. Following the war, he resumed his studies at the University of Kansas. He graduated with an AB in economics in 1946. He was hired by the accounting department of Link Belt Company of San Francisco. Later, he moved back to Lawrence and farmed for five years. In 1957 he received his JD from the University of Kansas Law School. During his law practice he was a municipal court judge from 1959-1967, and president of the Douglas County Bar Association in 1981.

In 1958 he married Edith Cottom Livingston and adopted her two children Stephen and Helen. Together, they had a son Martin William Pendleton. Edith and Martin both passed away in 1974 in an automobile accident.

When William retired he remained active in the community. He participated in many clubs including the KU Chancellors Club, Elizabeth M. Watkins Society, the Vestry of Trinity Episcopal Church and was treasurer in the 1960’s, Lawrence Breakfast Optimist Club was Optimist of the Year in 1992 and 1997, the Midland Railway Historical Association where he was a director, and the American Legion. He volunteered at the Heartland Medical Clinic at the Leo Center and Friends of Hidden Valley. When he was not volunteering or participating in clubs William enjoyed collecting one-cylinder antique engines, traveling and riding steam trains around the world, and going on rail excursions in his own Fairmont inspection car.

He passed away at the age of 95 on May 15th, 2015 at Pioneer Ridge Assisted Living in Lawrence, KS. Pendleton donated his body to research.

Pendleton graciously donated to the University of Kansas Endowment Association. He wished for the money to be used in reproductive biology for family planning and birth control research and counseling.

Dr. Louis R. Fletcher (1892 – 1973)

"Life is so precious and exciting, and there is so much to be learned, that I dislike to waste a minute." Louis R. Fletcher, M.D.

Dr. Louis R. Fletcher left an unforgettable and generous mark on the University of Kansas. Described as a farm boy from Harper, Kansas, Dr. Louis R. Fletcher attended the University of Kansas and Southwestern College for medical school. Hardworking, humble, and adventurous are just a few words to describe the life Dr. Louis R. Fletcher lived. Dr. Fletcher was a modest man who worked extremely hard for his opportunities and income. Throughout college he paid for his expenses by washing dishes, lawn keeping, and working wheat fields. Additionally, he took breaks in his schooling to save money by working in various employment opportunities in Alaska including working in the gold mines, ore processing mills, and as a bridge carpenter. He returned to KU for the 1917- 18 school year and then finished his last 2 years of education at Rush Medical College of the University of Chicago where he received his degree in medicine.

He spent much of his professional career (26 years) working for the United Fruit Company in hospitals in Panama, Guatemala, and Honduras. He served his country as a commissioned Lieutenant Commander in the Navy. Additionally, he also served as chief of surgery at the Camp White Naval Hospital in Medford, Oregon. He had a lifelong love of learning. He returned to KU for postgraduate study in anatomy, not for a degree, but for the inner desire to learn.

Dr. Fletcher rarely stayed idle in his work as he then served in many different medical positions. His adventurous spirit served as a driving factor as he traveled and worked in many different countries. He returned to the United Fruit Company for a few years, served at a hospital at Superior, Arizona, worked as the medical superintendent of the Valdez Community Hospital, was the project physician at the Naval Base at Point Barrow, and served as a surgeon for a construction company in the Marshall Islands. Following retirement from the medical profession, Dr. Fletcher spent time traveling to grand places. He began by sailing from New Orleans to South Africa and then continued his travels to Asia, Australia, and New Zealand.

Throughout his life, Dr. Louis R. Fletcher became intrigued with the prospect of being a “millionaire.” Fletcher made this happen through “frugality, skimping, and strict economy.” He invested his money and was very conservative with his spending and lifestyle. He lived modestly, ate low cost substantial food, and chose to travel by bus instead of train or plane. Dr. Fletcher humbly achieved that goal of a million dollars, in which he then said, “As you know, I have always dreamed of acquiring a million dollars. This has finally been accomplished and today I have given this million dollars to Kansas University, the school that I love so deeply and which has had such a tremendous good influence on my life. I 13 have done this with the greatest of pleasure and satisfaction.” His donation to the Kansas University Endowment Association has provided support for research in physiology, biochemistry, pharmacology, and anatomy at the University of Kansas Medical Center as well as construction of the Dr. Louis R. Fletcher Research Laboratories. The physiology department wants to extend a gracious and continued thank you to Dr. Louis R. Fletcher for the opportunities and support his generosity continues to provide.

Dr. Walter Joseph Meek (1878 – 1963)

Dr. Walter Joseph Meek demonstrated academic excellence throughout his life. Dr. Meek and his family’s generosity is continually valued and honored in the Physiology Department. Walter Joseph Meek was born in Dillion, KS in 1878. At age eight, Dr. Meek’s father passed away followed by his mother’s passing a few years later. Following their passing, he was raised with his first cousins. From a young age, Dr. Meek showed strong educational aspirations.

Dr. Meek graduated from the University of Kansas in 1902 where he was senior class president and editor of the school paper. As of 1983, Dr. Meek held the highest-grade point average of a University of Kansas Graduate. He continued his educational pursuits at Penn College and the University of Chicago obtaining his Ph.D. in Physiology in 1909. While pursuing his Ph.D. he taught at Penn College from 1903 – 1908 where he attained the rank of professor of biology. Dr. Meek then began teaching at the University of Wisconsin. He served as instructor in physiology (1908-1910), assistant professor (1910-1912), associate professor (1912- 1918), and professor (1918-1948). He then assumed the position of chairman of Physiology Department until his retirement in 1948.

Additional professional accomplishments at the University of Wisconsin include assistant dean of medicine from (1920 – 1942), acting dean (1942 – 1945), and associate dean from 1945 until his retirement. Dr. Walter Joseph Meek also held the commission of major in the Chemical Warfare Service during the World War I. A chemical warfare unit was set up at the University, and Dr. Meek assisted with discovering the biological effects of mustard gas, lewisite, and phosgene.

Dr. Meek married Crescence Eberley on December 26, 1906. Six years later, they had their first child, Joseph Walter Meek, born in 1912. Joseph became a law school professor at the University of New Mexico. Their second child, Mary Crescence Meek, born in 1917, worked as a stewardess for American Airlines. Their third and final son, John Sawyer Meek, was born a year later in 1918. He became a professor of chemistry at the University of Colorado. The Meek family was very adventurous, embarking on many different outdoor endeavors. They visited Switzerland to hike over the high passes and climbed Pikes Peak. They also spent time at Yellowstone and Glacier National Parks. Additionally, Dr. Meek enjoyed side hobbies including photography, gardening, repairing and refinishing antique furniture, and collecting shells and stamps.

Dr. Meek's contributions to the study of the history of medicine are nothing short of extraordinary. His bibliography consisted of 110 scientific papers and one of his most clinically relevant contributions was the discovery, in collaboration with Maurice H.

Seevers and Ralph M. Waters, that catecholamines cause ventricular fibrillation in dogs anesthetized with cyclopropane.

Upon Dr. Meek’s retirement in 1948 he remained at the University of Wisconsin as a research professor for an additional year. He continued to lecture at the University of Texas and served on a committee to establish a medical school in Gainesville, Florida. His death occurred quietly in 1963 at the age of 84. Mrs. Meek passed away in 1973 at the age of 92. His ashes are buried with his wife’s in her family’s burial plot in Pennsylvania. The Physiology Department extends remembrance and sincere gratitude to Dr. Meek and his family for the generosity bestowed upon the Physiology Department. The allocation of funds is still greatly valued and utilized within the Department to continue Dr. Meek’s passion of advancing medicine.

Abrahams Lectureship Established Mr. J. Hambleton Abrahams (1913 – 1996)

Abrahams and his wife, Julie, lived in Topeka, where he was born and raised. Mrs. Abrahams was a KU Endowment Association trustee. He attended Chattuck Military Academy, Northwestern University and graduated from the University of Chicago with a bachelor’s degree in philosophy. In 1978 he received an honorary doctor’s degree in Business from Washburn University. He served during World War II in the U.S. Navy and later in the Naval Reserve as an officer. Abrahams was active throughout the community. Serving as an officer or member on the board of banks, hospitals, the chamber of commerce, the Red Cross, and many other organizations.

Security Benefit is the parent company of the Security Benefit Group of Companies, a financial services organization that maintains more than $13 billion of life insurance in force and has $2 billion in assets under management. After joining the company in 1935 he later held the positions of secretary treasurer, executive vice president, president, and chairman. Abrahams encompassed the leadership skills to grow Security Benefit from a small, midwestern company to one of the largest life insurance companies in the United States.

The Security Benefit Group of Companies headquartered in Topeka, started an annual gift of $7,500 to the KU Endowment Association to fund the J Hambleton Abrahams lectureship in Physiology at KUMC. The lecture series honors Abrahams’s 50 years with Security Benefit.

According to Gilbert S. Greenwald, Ph.D., chairman of the Physiology Department in KUMC: “the funds will be used to bring annually to the center a person of national and international reputation in one of the physiology subspecialties: cardiovascular physiology, renal physiology, neurophysiology, endocrinology, biophysics or epithelial transport physiology.”

After 60 years of service for Security Benefit Abrahams retired in 1995. He stayed busy traveling between homes in Topeka, Colorado, and Arizona. Abrahams passed away at the age of 83 in 1996 one year after retirement.

Mr. James Osborn (1919 – 2018) Born December 18th 1919. Jim Osborn 98, passed away on February 6th, 2018 at the Kahala Nui skilled nursing unit in Honolulu, Hawaii. All members of our department express their sadness and deepest sympathy as we remember our benefactor, who always showed great interest and provided valuable and strong support for the research in reproductive physiology performed in our department. A memorial service was held March 12th, 2018 at the National Memorial Cemetary of the Pacific in Honolulu Hawaii.

Floral arrangment sent from the Department of Molecular & Integrative Physiology to the service

†Amy Cantilena, Ph.D. (1986 – 2017) A former student at KUMC, Amy Cantilena earned her doctorate in Molecular and Integrative Physiology in 2017. As an undergraduate student, Amy attended Villanova University where she received her B.S. in Chemistry.In 2005 she began at the Liver Diseases Branch of the National Institute of Diabetes and Digestive and Kidney Diseases in a biochemistry laboratory studying hepatitis B virus. After receiving a post-baccalaureate intramural research training award, she joined Dr. Cynthia Dunbar’s laboratory in the Hematology Branch of the National Heart, Lung and Blood Institute. Together they worked on two projects; one of them was directed to develop lentivirus to reprogram somatic cells into pluripotent stem cells. Her second project was oriented to determine if membrane polarity of hematopoietic progenitor cells was necessary for engraftment in a transplant model. She was later accepted into KUMC’s M.D./Ph.D. program and began medical school in August 2010. During her time at KUMC she researched the differences of immune- modulating properties of mesenchymal stem cells (MSC). She completed her first semester as a third-year medical student and completed her Ph.D. with Dr. Buddha Dawn this past spring. Amy passed away on December 16th, 2017 in a tragic plane accident along with her father Dr. Louis Cantilena. Louis was a professor of medicine in clinical pharmacology at the Uniformed Services University of Health Sciences in Bethesda, Maryland. Surviving are his wife Kathleen “Cathy” Conry Cantilena, two sisters; and her brother. Amy and Louis were laid to rest Thursday, December 28th, 2017 at All Souls Cemetery in Germantown, Maryland.

Department of Molecular & Integrative Physiology Faculty 2017 – 2018

(Left to right): Melissa Larson, Phil Lee, Ning Wang, John Thyfault, Lane Christenson, Andrei Belousov, Sam Enna, Steven LeVine, Gustavo Blanco, Michael Wolfe, E. Matthew Morris, Warren Nothnick, Paige Geiger, John Stanford

Not Pictured: Vargheese Chennathukuzhi, Leslie Heckert, Sumedha Gunewardena, Peter Smith, John Wood

Department of Molecular & Integrative Physiology Graduate Students 2017 – 2018

Front Row (left to right): Consuelo Perez Sanchez, Page Hayley, Fatimah Aljubran, Preethi Kunchala

Back Row (left to right): Cameron Fox, Alex Von Schulze, Adrianna Maurer, Kelly Fuller, Ashley Cloud, Rikki Nelson, Younshim Park, Elizabeth Thoenen, Ayushi Vashisht

Not Pictured: Zahraa Alali, Bradley Lamb, Jianzheng Wu

DEPARTMENT ROSTER July 1, 2017 – June 30, 2018

a. Faculty Primary Appointment in Physiology V. Gustavo Blanco, M.D., Ph.D., Professor & Kathleen M. Osborn Chair Andrei Belousov, Ph.D., Associate Professor Vargheese M. Chennathukuzhi, Ph.D., Associate Professor Lane K. Christenson, Ph.D., Associate Professor Salvatore J. Enna, Ph.D., Professor and Associate Dean for Research and Graduate Education Paige C. Geiger, Ph.D., Associate Professor Leslie L. Heckert, Ph.D., Marion M. Osborn Professor for Reproductive Sciences Phil Lee, Ph.D., Associate Professor Steven M. LeVine, Ph.D., Professor Warren Nothnick, Ph.D., Professor and department Vice Chair Peter G. Smith, Ph.D., John H. Wineinger, Professor, Senior Associate Dean for Research John A. Stanford, Ph.D., Associate Professor John P. Thyfault, Ph.D., Associate Professor Ning Wang, Ph.D., Assistant Professor Michael W. Wolfe, Ph.D., Associate Professor John G. Wood, Ph.D., Professor and Director of Educational Programs

Emeritus Paul D. Cheney, Ph.D., Professor Norberto C. Gonzalez, M.D., Professor Thomas J. Imig, Ph.D., Professor Lawrence P. Sullivan, Ph.D., Professor Joseph S. Tash, Ph.D., Professor Paul F. Terranova, Ph.D., Professor James L. Voogt, Ph.D., Professor

Stowers Affiliates Peter Baumann, Ph.D., Professor Ariel Bazzini, Ph.D., Assistant Professor Randal Halfmann, Ph.D., Assistant Professor Scott Hawley, Ph.D., Professor Sue Jaspersen, Ph.D., Associate Professor Nicolas Rohner, Ph.D., Assistant Professor Kausik Si, Ph.D., Professor Sarah Zanders, Ph.D., Assistant Professor

Research Track Faculty Sumedha Gunewardena, D.Phil., Research Assistant Professor Melissa Larson, Ph.D., Research Assistant Professor E. Matthew Morris, Ph.D., Research Assistant Professor

Joint Appointment in Physiology Shrikant Anant, Ph.D., (Cancer Biology) Richard Barohn, M.D., (Neurology) Sandra Billinger, PT, Ph.D., FAHA, (Physical Therapy and Rehabilitation Science) William Brooks, Ph.D., (Neurology, Director of Hoglund Brain Imaging Center) Jeffrey Burns, M.D., (Neurology) Mark E. Chertoff, Ph.D., (Hearing and Speech) In-Young Choi, Ph.D., (Neurology) Animesh Dhar, Ph.D., (Cancer Biology) Navneet Dhillon, Ph.D., (Internal Medicine – Pulmonary Division) Shawn Frost, Ph.D., (Physical Therapy and Rehabilitation Science) Tomoo Iwakuma, M.D., Ph.D., (Cancer Biology) Jill Jacobson, M.D., (Pediatrics) Benyi Li, Ph.D., (Urology) Joan Lewis-Wambi, Ph.D., (Cancer Biology) Joshua Mammen, M.D., (General Surgery) Courtney Marsh, M.D., M.P.H. (Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division) Ajay Nangia, M.B.,B.S., FACS, (Urology) Jules Nazzaro, M.D., (Neurosurgery) Randolph Nudo, Ph.D., (Physical Medicine and Rehabilitation) Janet Pierce, Ph.D., ARNP, CCRN, (Nursing) Jeff Radel, Ph.D., (Occupational Therapy) William (Zhiming) Suo, M.D., (Neurology) Russell H. Swerdlow, M.D., (Neurology) Shahid Umar, Ph.D., (Surgery) Darren Wallace, Ph.D., (Nephrology and Hypertension) Carl Weiner, M.D., M.B.A., (OB/GYN) Danny Welch, Ph.D., (Cancer Biology) Alan Yu, MB, B.Chir., (Internal Medicine, Nephrology Division)

b. Graduate Students Joined Prelims Candidate Requirements Physiology Fulfilled

Zahraa Alali 08/15 05/16 Ph.D. Fatimah Aljubran 08/17 Ph.D. Ashley Archer (Ward) 08/14 04/15 Ph.D. 01/18 Li Chen 06/11 04/12 Ph.D. 06/18 Ashley Cloud 08/18 Ph.D. Joshua Curry 06/14 11/15 M.D./Ph.D. 05/18 Blake Ebner 06/14 11/15 M.D./Ph.D. 05/18 Cameron Fox 06/15 05/18 M.D./Ph.D. Kelly Fuller 06/18 Ph.D. Page Hayley 08/17 Ph.D. Liying Li 06/11 04/12 Ph.D. 06/17 Rikki Nelson 09/17 Ph.D. Zelha Nil 08/14 05/15 Ph.D. 06/18 Younshim Park 08/15 05/16 Ph.D. Archana Raman 08/12 04/13 Ph.D. 06/17 Diego Paez- Moscoso 01/18 Ph.D. Consuelo Perez Sanchez 08/17 Ph.D. Alex Von Schulze 08/17 Ph.D. Elizabeth Thoenen 08/17 M.D./Ph.D. Jianzheng Wu 08/16 05/18 Ph.D.

24 c. Postdoctoral Fellows d. Temporary Students Pavla Brachova, Ph.D. Marco Tulio Correa Pessoa Colin McCoin, Ph.D. Abdouili Njai Fu Chen (Jane) Yang, Ph.D. India Barnett Yi Feng, Ph.D. Ganesh Aruna Praveen Chakravarthi Ph.D. Abril Lara Chu- Yu Lee Ph.D. Kavya Shivashankar Sean Riordan Ph.D. Sean Ellis Xiaoyu Zhang Ph.D. Lauren Stubbs Aritra Bhattacherjee Ph.D. Tyler Elmendorf Jonathan Warren Emily Fey Emma Renwick

e. Research Staff Gladis Sanchez, M.D. – Research Associate Jana Belousova, M.S. – Senior Research Associate Jake Cushing – Research Technician Jeffrey McDermott – Senior Research Associate Julie Allen – Senior Research Associate Mariad Thatcher – Research Associate at Hoglund Brain Imaging Center Naomi Holloway – Research Assistant Peter Adany – Senior Research Scientist at Hoglund Brain Imaging Center Theodore Budden – Part-time Research Technician Xiaoman Hong, M.D. – Senior Research Associate Anuradha Chakrabarty, Ph.D. – Senior Scientist Sarah Tague, Ph.D. – Senior Scientist Fengyan Deng – Research Assistant Julia Draper – Research Associate Clara Amat Fernandez – Clinical Research Coordinator Fnu Sornakala Ganeshkumar – Research Assistant Amanda Graham – Research Associate Lesya Holets, Ph.D. – Senior Scientist Roberto Noland Mora – Research Technician Amamika Ratri – Research Technician (part-time) Kimberly Stanford – Director of Operations Catherine Traxler – Research Assistant Zhaohui Liao, M.D. – Research Associate Dora Krizsan-Agbas – Senior Scientist Illya Bronshteyn – Research Associate Bailey Bye – Research Associate Fengyan Deng – Research Assistant Julia Draper – Research Associate Clara Amat Fernandez – Clinical Research Coordinator Fnu Sornakala Ganeshkumar – Research Assistant Amanda Graham – Research Associate Lesya Holets, Ph.D. – Senior Scientist Roberto Noland Mora – Research Technician Amamika Ratri – Research Technician (part-time) Kimberly Stanford – Director of Operations Catherine Traxler – Research Assistant Zhaohui Liao, M.D. – Research Associate Dora Krizsan-Agbas – Senior Scientist Illya Bronshteyn – Research Associate Bailey Bye – Research Associate

f. Support Staff Alexis Battershell – Student Assistant MacKenzie Boone – Student Assistant Liam Higgins – Accountant Lynn LeCount – Managing Editor Jennifer McNichols – Editorial Coordinator Shari Standiferd – Director of Operations Jennifer Wallace – Accountant

Activities of Graduate Students

Zahraa Alali

Publications: Nothnick WB, Marsh C, Alali. Z. Future Directions in Endometriosis Research and Therapeutics. Current Women`s Health Reviews 2018; 14:189 – 194. Alali Z, Swan K, Nothnick WB. Matrix Metalloproteinases and Endometriosis. Current Women's Health Reviews 2018; 14:147 – 153.

Abstracts: Alali Z, Falcone T, Nothnick WB. miR-451a-c-MYC Pathway Regulation of 60S Acidic Ribosomal Protein P1 (RPLP1) Expression: A Novel Pathway in Endometriotic Lesion Tissue Survival. In: Reproductive Sciences; 2018. pp. 108.

Presentations: The 14th Annual Gilbert S. Greenwald Symposium on Reproduction and Regenerative Medicine: Oral Presentation. The University of Kansas Medical Center, Kansas City, KS. October 19 – 20, 2017 65th Annual Meeting for the Society for Reproductive Investigation: Oral Presentation. San Diego, CA. March 7 – 10, 2018, San Diego, CA

Seminars: A novel Role of Ribosomal Protein RPLP1 in Endometriosis Pathophysiology /The University of Kansas Medical Center, Molecular and Integrative Physiology Departmental seminar series, Kansas City, KS/ February 29, 2018, Kansas City, KS.

Meetings Attended: 65th Annual Meeting for the Society for Reproductive Investigation// San Diego, CA /March 7 – 10, 2018, San Diego, CA

Honors/Awards: SRI- IN- Training Investigator Travel Award, Society for Reproductive Investigation, February 2018 Physiology Society Travel Award, The University of Kansas Medical Center, March 2018 Trainee Oral Presentation Award, The 14th Annual Gilbert S. Greenwald Symposium on Reproduction and Regenerative Medicine, Kansas City, KS, October 2017 Past President – KUMC Physiology Society

Ashley Cloud

Presentations: Student Research Forum: Oral Presentation. KUMC. April 2nd, 2018

Meetings Attended: Greenwald Symposium. KUMC. October 19 – 20, 2017

Honors/Awards: Physiology Society, Crescence E. Meek Excellence Award Top Oral Presentation in Molecular and Integrative Physiology, Student Research Forum Other: President – KUMC Physiology Society

Page Hayley

Publications: Cooper MA, Jack MM, Ryals JM, Hayley P, Escher T, Koch LG, Britton SL, Raupp SM, Winter MK, McCarson KE, et al. 2017. Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain. Brain Behav. 7(10):e00780.doi:10.1002/brb3.780.

Other Activities: Acceptance into the Kansas University Training Program in Neurological and Rehabilitation Sciences (T32 Program), an institutional training program funded by the National Institutes of Health

Rikki Nelson

Honors/Awards: Kathleen M. Osborn Fellowship in Reproductive Physiology Fall 2017

Consuelo Perez Sanchez

Publications: Michael A. Cooper, Blaise W. Menta, Consuelo Perez-Sanchez, Megan M. Jack, Zair W. Khan, Janelle M. Ryals, Michelle Winter, Douglas E. Wright. 2018. A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice. Experimental Neurology Volume 306. 149 – 157.

Elizabeth Thoenen

Publications: Parrales, A. Thoenen, E. and Iwakuma T. (2018) “The interplay between mutant p53 and the mevalonate pathway” Cell Death and Differentiation 25(3): 460 – 470

Presentations: KUCC Cancer Biology Program Meeting: Poster Presentation. The Embassy Suites Kansas City. June 8, 2018 Student Research Forum – Poster Presentation. KUMC. April 2 – 3, 2018 University of Kansas Cancer Center Symposium- Poster Presentation. University of Kansas Edwards Campus. December 1, 2017 Greenwald symposium- Poster Presentation. KUMC. October 19 – 20, 2017

Meetings Attended: KUCC Cancer Biology Program Meeting/The Embassy Suites Kansas City (Olathe Hotel & Conference Center)/June 8,2018 Student Research Forum/University of Kansas Medical Center/ April 2 – 3, 2018 University of Kansas Cancer Center Symposium/University of Kansas Edwards Campus/December 1, 2017 Greenwald Symposium/University of Kansas Medical Center/ October 19 – 20, 2017 Other: Social Chair – KUMC Physiology Society

Alex Von Schulze

Publications: Von Schulze, Alex, Colin S. McCoin, Chiemela Onyekere, Julie Allen, Paige Geiger, Gerald W. Dorn, E. Matthew Morris, and John P. Thyfault. "Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α, and BNIP3 mediated mitophagy." The Journal of Physiology (2018). Archer, Ashley E., Robert S. Rogers, Alex T. Von Schulze, Joshua L. Wheatley, E. Matthew Morris, Colin S. McCoin, John P. Thyfault, and Paige C. Geiger. "Heat Shock Protein 72 Regulates Hepatic Lipid Accumulation." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2018). Archer, Ashley E., Alex T. Von Schulze, and Paige C. Geiger. "Exercise, heat shock proteins and insulin resistance." Phil. Trans. R. Soc. B 373, no. 1738 (2018): 20160529. Wilkins, Heather M., Ian Weidling, Scott Koppel, Xiaowan Wang, Alex T. Von Schulze, and Russell H. Swerdlow. "Mitochondrial Function and Neurodegenerative Diseases." In The Molecular and Cellular Basis of Neurodegenerative Diseases, pp. 369 – 414. 2018.

Presentations: KUMC Student Research Forum: Poster Presentation. Kansas City, KS. April 26, 2018 Keystone Symposia – Bioenergetics and Metabolic Disease: Poster and Oral Presentation. Keystone, CO. January 21-25, 2018 The 2017 Saltin International Graduate Course in Exercise & Clinical Physiology: Poster and Oral Presentation. Ottawa, Ontario, Canada. September 18 – 21, 2017

Meetings Attended: Keystone Symposia- Bioenergetics and Metabolic Disease: Keystone, CO. January 21 – 25, 2018 The 2017 Saltin International Graduate Course in Exercise & Clinical Physiology: Ottawa, Ontario, CAN. September 18 – 21, 2017

Honors/Awards: KUMC Student Research Forum: Group 2 Poster Session – 1st place Awarded the Self Graduate Fellowship

Jianzheng Wu

Publications: Khan T*, Kandola TS*, Wu J*, Venkatesan S*, Ketter E*, Lange JJ, Rodriguez Gama A, Box A, Unruh JR, Cook M, Halfmann R. Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior. Molecular Cell 7(1), 155 – 168. PubMed PMID: 29979963; PubMed Central PMCID: PMC6086602. (*equal authorship)

Presentations: American Society of Cell Biology: Poster Presentation. Philadelphia, PA. December 5th, 2017 Student Research Forum: Oral Presentation. KUMC, KS. April 2nd, 2018 Protein Homeostasis in Health and Disease: Poster Presentation. Cold Spring Harbor Laboratory, NY. April 19th, 2018

Seminars: “Characterizing self- assembly of AB42 mutants in vivo”, Stowers Institute, MO. August 10th, 2018

Meetings Attended: Protein Homeostasis in Health and Disease, Cold spring Harbor Laboratory, NY. April 17 – 21, 2018. American Society for Cell Biology, Philadelphia, PA. December 2 – 6, 2017.

Honors/Awards: ASCB (American Society for Cell Biology) Travel Award 2017

COURSES TAUGHT

Medical Curriculum Core Courses CORE 815 – Cardiopulmonary. Dr. Wood, Dr. Geiger, Dr. Gonzalez, and Dr. Smith

CORE 820 – Gastrointestinal Tract and Nutrition. Dr. LeVine

CORE 825 – Renal and Endocrine System. Dr. Wolfe and Dr. Blanco

CORE 830 – Reproduction and Sexuality. Dr. Wolfe

CORE 840 – Brain and Behavior. Dr. LeVine and Dr. Stanford

CORE 860 – Integration and Consolidation, Dr. Blanco and Dr. Wood

Departmental Graduate Courses PHSL 800 – Medical Physiology. Dr. Smith

PHSL 834 – Reproductive Physiology. Dr. Chennathukuzhi

PHSL 835 – Integrative Physiology of Exercise. Dr. Geiger, Dr. Thyfault, and Dr. Gonzalez

PHSL 842 – Comprehensive Human Physiology. Dr. Belousov, Dr. Christenson, Dr. Chennathukuzhi, Dr. Geiger, Dr. LeVine, Dr. Wolfe, Dr. Heckert and Dr. Nothnick

PHSL 843 – Physiology of Disease. Dr.LeVine, Dr. Nothnick, Dr. Christenson, Dr. Chennathukuzhi, Dr. Thyfault, Dr. Wolfe, Dr. Stanford, Dr. Heckert, Dr. Geiger, and Dr. Blanco

PHSL 846 – Advanced Neuroscience. Dr. Stanford, Dr. Cheney, Dr. Lee, and Dr. Smith

PHSL 848 – Molecular Mechanisms of Neurological Disorders. Dr. LeVine, Dr. Belousov, Dr. Stanford

PHSL 851 – Seminar Course. Dr. Christenson

IGPBS Courses GSMC 851 – Molecular Genetics. Dr. Chennathukuzhi, Dr. Christenson

GSMC 853 – Cellular Structure. Dr. Belousov and Dr. Blanco

GSMC 854 – Cell Communication. Dr. Nothnick

GSMC 852 – Introduction to Biomedical Research. Dr. Christenson

GSMC 856 – Introduction to Research Ethics. Dr. Wolfe

DEPARTMENT SEMINARS

The Department Seminar program was directed by Dr. Vargheese Chennathukuzhi. Forty-five speakers made presentations, ten of which were from outside the university. In addition to support from the department, the J. Hambleton Abrahams Lectureship in Physiology Endowment Fund, Kathleen M. Osborn Memorial Lectureship in Physiology Endowment Fund, the Office of the Dean of the School of Medicine, the KIDDRC, Landon Center of Aging and the Center for Reproductive Sciences, Dr. Louis R. Fletcher Endowment Physiology Fund, and the School of Medicine Bohan Visiting Professor Program made important financial contributions to our program.

July 31, 2017 Faculty Candidate Seminar “Mechanism of Meotic Initiation in Ning Wang, Ph.D. Mammalian Germ Cells” Assistant Professor Obstetrics Harvard Medical School Massachusetts General Hospital Boston, MA Funded by the Dr. Louis R. Fletcher Endowment Physiology Fund

August 28, 2017 “Epigenetic Regulation of Histone Faculty Candidate Seminar Eviction During Spermatogenesis” Lacey Luense, Ph.D. Post-Doctoral Fellow Department of Cellular & Developmental Biology University of Pennsylvania Philadelphia, PA Funded by the Dr. Louis R. Fletcher Endowment Physiology Fund

September 11, 2017 “Complex Contributions of Neuronal Andrei Belousov, Ph.D. Gap Junctions to Cell Death and Associate Professor Survival” Molecular & Integrative Physiology KUMC

September 18, 2017 “Protonation-Dependent Conformational Alexey S. Ladokhin, Ph.D. Switching in Membrane Proteins” Associate Professor Biochemistry and Molecular Biology KUMC

September 25, 2017 “New Insights into the Interplay Between Chad Slawson, Ph.D. O-GlcNAc and Metabolism” Associate Professor Biochemistry and Molecular Biology KUMC

October 2, 2017 R. Scott Rector, Ph.D. “Hepatocellular eNOS and NAFLD Assistant Professor Susceptibility” Nutrition & Exercise Physiology and Medicine-GI University of Missouri, Columbia, MO Hosted by Dr. John Thyfault, Ph.D. Associate Professor Molecular and Integrative Physiology KUMC

October 9, 2017 Thomas Mueller, Ph.D. “The Zebrafish Amygdaloid Complex- Research Assistant Professor Evolution and Deep Homologies with Biology Mammals” Kansas State University, Manhattan, KS Hosted by Dr. John Stanford, Ph.D. Associate Professor Molecular and Integrative Physiology KUMC

October 16, 2017 Sean M. Riordan, Ph.D. “Variations in Variants and Variability: Research Assistant Professor Tackling Genetic Susceptibility to Pediatrics Bilirubin” Division of Child Neurology Children’s Mercy Kansas City Hosted by Dr. John Stanford Associate Professor Molecular and Integrative Physiology KUMC

October 23, 2017 “Claudin-2, Calcium, and Kidney Joshua Curry Stones: A Tale of Two Tissues” Graduate Student Molecular & Integrative Physiology KUMC

October 30, 2017 “Extracellular Vesicles as a Mechanism Sarah Dallas, Ph.D. for Cell-Cell Communication in Bone” Lee M. and William Lefkowitz Endowed Professor University of Missouri, Kansas City School of Dentistry, Department of Oral and Craniofacial Sciences Hosted by Dr. Lane Christensen Associate Professor Molecular and Integrative Physiology KUMC

November 6, 2017 Panying Rong, Ph.D. “Toward better understanding and Assistant Professor assessment of motor speech Department of Speech- Language- disorders- The application of Hearing and Disorders biobehavioral and quantitative University of Kansas approaches” Hosted by Dr. John A. Stanford Associate Professor Molecular & Integrative Physiology KUMC

November 13, 2017 School of Medicine Bohan “Can Connexins Fill the Gap in Stroke Distinguished Lecturer Therapeutics?” Christian C.G. Naus, Ph.D. Professor Department of Cellular & Physiological Sciences Canada Research Chair in Gap Junctions & Disease The University of British Columbia Vancouver, British Columbia Hosted by Dr. Andrei Belousov Associate Professor Molecular and Integrative Physiology KUMC Sponsored by the School of Medicine Bohan Visiting Professor Program and the J. Hambleton Abrahams Lectureship in Physiology Endowment Fund

November 27, 2017 KUMC“Orchestrating the Extracellular A.J. Mellott, Ph.D. Environment to Induce Stem Cell Research Assistant Professor Differentiation and Tissues Repair” Plastic Surgery

December 4, 2017 Kathleen M. Osborn Memorial “Preterm Birth: Genes and the Lectureship Environment” Jerome F. Strauss, M.D., Ph.D. Professor Department of Obstetrics and Gynecology, Division of Reproductive Biology & Research Virginia Commonwealth University Richmond, Virginia Funded by the Kathleen M. Osborn Memorial Endowment Fund Hosted by Dr. Leslie Heckert, Marion M. Osborn Professor for Reproductive Sciences, Physiology KUMC Dr. Lane Christenson Associate Professor Molecular and Integrative Physiology KUMC

December 11, 2017 In-Young Choi, Ph.D. “Magnetic resonance spectroscopy Associate Professor (MRS) of the living brain: What it can tell Director of Magnetic Resonance us” Science Hoglund Brain Imaging Center KUMC

December 18, 2017 Ashley E. Archer “Heat Shock Proteins in Liver Graduate Student Metabolism” Molecular & Integrative Physiology KUMC

January 8, 2018 M.A. Karim Rumi, Ph.D. “Role of ESR2 in female fertility” Associate Professor Department of Pathology and Laboratory Medicine Institute for Reproductive Health and Regenerative Medicine KUMC

January 22, 2018 “Tissue-type specific measurement of Phil Lee, Ph.D. neurochemicals and cerebral blood flow Associate Professor using MRI and MRS” Director of Magnetic Resonance Technology Hoglund Brain Imaging Center KUMC

January 29, 2018 Blake Ebner “The Role of Putative Prioin-Like Graduate Student Protein, CPEB2, in Translation and Molecular and Integrative Physiology Long-Term Memory” KUMC

January 29, 2018 “Heath Shock Protein 72 Reguation of Dissertation Defense, 1:30 p.m. Beller Metabolism” Conference Center Ashley Archer Graduate Student Molecular & Integrative Physiology KUMC

February 5, 2018 Leonard Dobens, Ph.D. “Complementary screens for new genes Professor mediating the ability of the School of Biological Sciences pseudokinase Tribbles to antagonize Division of Molecular Biology and insulin signaling” Biochemistry University of Missouri- Kansas City Hosted by Andrei Belousov, Ph.D.; Associate Professor Department of Molecular and Integrative Physiology KUMC

February 12, 2018 Elin Grundberg, Ph.D. “Capturing functional epigenomes for Roberta D. Harding & William F. insight into metabolic disease Bradley, Jr. Endowed Chair in Genomic susceptibility” Research Faculty Children’s Research Institute, Children’s Mercy Hospital Kansas City Associate Professor Department of Pediatrics University of Missouri- K.C. School of Medicine Hosted by John Thyfault, Ph.D.; Associate Professor, Molecular and Integrative Physiology, KUMC and Leslie Heckert, Ph.D.; Marion M. Osborn Professor for Reproductive Sciences, Molecular and Integrative Physiology KUMC

February 19, 2018 “Regulated assembly of a prion-like Zelha Nil phosphatase, CG5830, controls its Graduate Student phosphatase activity and embryonic Molecular and Integrative Physiology development” KUMC

February 26, 2018 Zahraa Alali “A novel Role or Ribosomal Protein Graduate Student RPLP1 in Endometriosis Department of Molecular and Integrative Pathophysiology” KUMC

March 5, 2018 School of Medicine Bohan “Neural Cardiovascular Regulation in Distinguished Lecturer Type 2 Diabetes Patients” Paul J. Fadel, Ph.D. Director, Human Neural Cardiovascular Control Lab Professor, Department of Kinesiology Associate Dean for Research, CONHI University of Texas Arlington Arlington, TX Hosted by John Thyfault, Ph.D.; Associate Professor Department of Molecular and Integrative Physiology KUKMC Sponsored by the School of Medicine Bohan Visiting Professor Program and the J. Hambleton Abrahams Lectureship in Physiology Endowment Fund

March 12, 2018 David Schulz. Ph.D. “Plasticity in the nervous system in Associate Professor response to injury: compensatory and Division of Biological Sciences pathological” University of Missouri- Columbia Hosted by Andrei Belousov, Ph.D.; Associate Professor Department of Molecular and Integrative Physiology KUMC

April 2, 2018 “Targeting Glycolysis to Promote Brain Liquin Zhao, Ph.D. Resilience against Alzheimer’s Disease” Assistant Professor Department of Pharmacology & Toxicology School of Pharmacy University of Kansas

April 9, 2018 “Redox Dysregulation Promotes Julie Kim, Ph.D. Survival of Uterine Fibroids” Susy Y. Hung Associate Professor Obstetrics and Gynecology Division of Reproductive Science in Medicine Robert H. Lurie Comprehensive Cancer Center Northwestern University, Chicago, IL Sponsored by the J. Hambleton Abrahams Lectureship in Physiology Endowment Fund Hosted by The Physiology Society Department of Molecular and Integrative Physiology KUMC

April 16, 2018- Cancelled “The Philosophy of Neuroscience: How Sarah Robbins Ph.D. Optogenetics is revolutionizing the Assistant Professor Study of Memory” Department of Philosophy University of Kansas- Lawrence

April 23, 2018-Postponed to Fall 2018 School of Medicine Bohan “How Rho GTPases led us to new areas Distinguished Lecturer of biology and disease” Richard A. Ceroine, Ph.D. Goldwin Smith Professor of Pharmacology and Chemical Biology Departments of Molecular Medicine & Chemistry and Chemical Biology Cornell University, Ithaca, NY Hosted by Lane Christenson, Ph.D. Associate Professor Department of Molecular and Integrative Physiology KUMC Sponsored by the School of Medicine Bohan Visiting Professor Program and the J. Hambleton Abrahams Lectureship in Physiology Endowment Fund

May 3, 2018 “Sex, Drugs, and Pain” James L. Voogt Lecture in Neuroenddocrinology Jon D. Levine, M.D., Ph.D. Professor Department of Medicine, Oral and Maxillofacial Surgery, and Physiological Nursing Vice Chair Oral Surgery Scientific Investigator, The Rosalind Russell Medical Research Center for Arthritis University of California, San Francisco Sponsored by the Institute for Reproductive Health & Regenerative Medicine, James L. Voogt Lectureship Fund, Department of Molecular and Integrative Physiology, and the Bohan Visiting Professor Program

May 4, 2018 Exercise is Medicine Conference “Benefits of Exercise for Aging”

Marcus Bamman, Ph.D. “Promoting Healthy Aging of Professor Skeletal Muscle through Departments of Physiology & Biophysics, Medicine Exercise” Nutrition Sciences Director, Center for Exercise Medicine University of Alabama Birmingham School of Medicine Hosted by John Thyfault, Ph.D., and Paige Geiger, Ph.D.; Associate Professors Department of Molecular and Integrative Physiology KUMC

Lara Boyd, P.T., Ph.D. “High Intensity Exercise Facilitates Canada Research Chair (Tier II) Motor Learning: A Novel Intervention for Neurobiology of Motor Learning Stroke?” Director, Brain Behavior Laboratory University of British Columbia Hosted by John Thyfault, Ph.D. and Paige Geiger, Ph.D.; Associate Professors Department of Molecular and Integrative Physiology KUMC

Susan Gilshrist, M.D. “Cardiorespiratory fitness to mitigate Associate Professor cardiovascular risk in cancer patients” Department of Clinical Cancer Prevention and Cardiology Hosted by John Thyfault, Ph.D. and Paige Geiger, Ph.D., Associate Professors Department of Molecular and Integrative Physiology KUMC

May 7, 2018 Eduardo Rosa-Molinar, Ph.D.-Cancelled “Deciphering Synaptic Diversity” Director Microscopy & Analytical Imaging Research Resource Core Laboratory Professor Pharmacology and Toxicology; Neuroscience Graduate Program University of Kansas- Lawrence

Dissertation Defense. 2:00 p.m. Lied “The Role of Claudin-2 in the Proximal Auditorium Tubule and Kidney Stone Disease” Joshua Curry Graduate Student Molecular and Integrative Physiology KUMC

May 11, 2018 Dissertation Defense, 1:30 p.m. Lied “The Role of Putative Prion-like Protein, Auditorium CPEB2, in Translation and Long-term Blake Ebner Memory” Graduate Student Molecular and Integrative Physiology KUMC

May 14, 2018 School of Medicine Bohan “Gastric Bypass: Taste, Palatability, and Distinguished Lecturer Food Selection” Alan Spector, Ph.D. Distinguished Research Professor Department of Psychology and Program in Neuroscience Florida State University, Tallahassee, FL Hosted by John Thyfault, Ph.D., Associate Professor Department of Molecular and Integrative Physiology KUMC Randolph J. Nudo, Ph.D., Professor & Vice Chair Research Department of Rehabilitation Medicine and Landon Center of Aging Sponsored by the School of Medicine Bohan Visiting Professor Program and the J. Hambleton Abrahams Lectureship in Physiology Endowment Fund

May 21, 2018 “Bilbo Baggins, Owens Meany and the Voyages Seminar Series Passage of Time” Michael J. Parmely, Ph.D. Professor and Former Chair Microbiology, Molecular Genetics and Immunology KUMC

June 19, 2018 Dissertation Defense, 2:00 p.m. Stowers "Regulated Assembly of Prion-Like Institute for Medical Research Phosphate, CG5830, Controls its Zelha Nil Phosphate Activity and Embryonic Graduate Student Development in Drosophila Molecular and Integrative Physiology Melanogangster” KUMC

June 27, 2018 Dissertation Defense, 9:00 a.m. Stowers “Characterization of the Mammalian Institute for Medical Research Methyltransferase Tgs1” Li Chen Graduate Student Molecular & Integrative Physiology KUMC

PUBLICATIONS

a. Manuscripts Published

Archer AE, Rogers RS, Von Schulze AT, Wheatley JL, Morris EM, McCoin CS, Thyfault JP, Geiger PC. Heat shock protein 72 regulates hepatic lipid accumulation. Am J Physiol Regul Integr Comp Physiol. 2018 June 20. [epub ahead of print]. Archer, A.E., Von Schulze, A., Geiger, P.C. “Exercise, heat shock proteins and insulin resistance” in Heat shock proteins in health and disease, theme issue of Philosophical Transactions of the Royal Society B. Ed. Blatch, Price, Edkins and Pockley. 2017. Bani-Ahmed A, Savage C, Nudo RJ, Lee P, Choi IY, Cirstea CM. Primary motor cortex ipsilateral to the paretic arm - a potential neural substrate for compensatory trunk use in chronic stroke. Int J Phys Med Rehabil (2017) 5: 3. Barbosa TC, Kaur J, Holwerda SW, Young CN, Curry TB, Thyfault JP, Joyner MJ, Limberg JK, Fadel PJ. Insulin increases ventilation during euglycemia in humans. Am J Physiol Regul Integr Comp Physiol. 2018 [Epub ahead of print]. Belousov, A.B., Fontes, J.D., Freitas-Andrade, M. and Naus, C.C. (2017) Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease. BMC Cell Biology 18 (Suppl 1), 4. PMID: 28124625, PMCID: PMC5267333 Belousov, A.B., Nishimune, H., Denisova, J.V. and Fontes, J.D. (2018) On possible role of neuronal connexin 36 in amyotrophic lateral sclerosis progression. Neurosci Lett 666, 1-4. PMID: 29246791 Bettler, B., Crunelli, V., and Enna, S.J. A Tribute to Norman Bowery, Neuropharmacology 136: 1-2, 2018. Bhattacherjee A, Mu Y, Winter MK, Knapp JR, Eggimann LS, Gunewardena SS, Kobayashi K, Kato S, Krizsan-Agbas D, Smith PG. “Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome''. Proc Natl Acad Sci U S A. 2017 Jul 31. pii: 201618210. doi: 10.1073/pnas.1618210114. PMID: 28760966 Bhattacherjee A, Winter MK, Eggimann LS, Mu Y, Gunewardena S, Liao Z, Christianson JA, Smith PG. “Motor, Somatosensory, Viscerosensory and Metabolic Impairments in a Heterozygous Female Rat Model of Rett Syndrome''. Int J Mol Sci. 2017 Dec 29;19(1). pii: E97. doi: 10.3390/ijms19010097. PMID: 29286317 Blanco A and Blanco G. Medical Biochemistry textbook. Elsevier publisher’s, 2017. Booth FW, Roberts CK, Thyfault JP, Ruegsegger GN, Toedebusch RG. Role of inactivity in chronic diseases: evolutionary insight and pathophysiological mechanisms. Physiol Rev. 2017 Oct 1;97(4):1351-1402. Bylund, D.B. and Enna, S.J. Receptor Binding Assays and Drug Discovery. In Gavril. W. Pasternak, Joseph T. Coyle (eds.), Apprentices to Genius: A Tribute to Solomon H. Snyder, Vol. 82, Advances in Pharmacology, pp. 21-34, Academic Press, United Kingdom, 2018.

Caraci, F., Enna, S.J., Zohar, J., Racagni, G., van den Brink, W., Kasper, S., Koob, G.F., Pariante, C.M., Piazza, P.V., Yamada, K., Spedding, M., and Drago, F. A New Nomenclature for Classifying Psychotropic Drugs. British Journal of Clinical Pharmacology, 83:1614-1616, 2017. Casillan AJ, Chao J, Wood JG, Gonzalez NC. Acclimatization of the systemic microcirculation to alveolar hypoxia is mediated by an iNOS-dependent increase in nitric oxide availability. JAP, 123(4), 974-982, 2017. Chappell I, Lee P, McIff TE, Toby EB, Fischer KJ. Effects of Scapholunate Ligament Injury and Surgical Repair on Wrist Cartilage T2 Relaxation Time. J Musculoskel Res (2017) 20: https://doi.org/10.1142/S0218957717500063. Choi IY, Lee P, Hughes AJ, Denney DR, Lynch SG. Longitudinal changes of cerebral glutathione (GSH) levels associated with the clinical course of disease progression in patients with secondary progressive multiple sclerosis. Mult Scler (2017) 23(7): 956-962. PMID: 27620894 PMCID: PMC5344731 Choi I-Y, Lee P, Adany P, Hughes AJ, Belliston S, Denney DR, Lynch SG. In vivo evidence of oxidative stress in brains of patients with progressive multiple sclerosis. Mult Scler (2017): DOI: 10.1177/1352458517711568. PMID: 28569645 Cooper MA, Jack MM, Ryals JM, Hayley P, Escher T, Koch LG, Britton SL, Raupp SM, Winter MK, McCarson KE, Geiger PC, Thyfault JP, Wright DE. Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain. Brain Behav. 2017 Sep 6;7(10)e00780. Cirstea CM, Choi IY, Lee P, Peng H, Kaufman CL, Frey SH. Magnetic resonance spectroscopy of current hand amputees reveals evidence for neuronal-level changes in former sensorimotor cortex. J Neurophysiol (2017) 117(4): 1821- 1830. PMID: 28179478 PMCID: PMC5390283 Cirstea CM, Lee P, Craciunas SC, Choi IY, Burris J, Nudo RJ. Pre-therapy neural state of bilateral motor and premotor cortices predicts therapy gain after subcortical stroke – a pilot study. AM J Phys Med Rehabil (2017): DOI: 10.1097/PHM.0000000000000791. PMID: 28737516 Craciunas SC, Gorgan MR, Ianosi B, Lee P, Burris J, Cirstea CM. Remote motor system metabolic profile and surgery outcome in cervical spondylotic myelopathy. J Neurosurg Spine (2017): 1-11. PMID: 28304238 E. Matthew Morris, C.S. McCoin, J.A. Allen, M.L. Gastecki, L.G. Koch, S.L. Britton, J.A. Fletcher, X. Fu, W.X. Ding, S.C. Burgess, R.S. Rector, and J.P. Thyfault. Aerobic Capacity mediates susceptibility for the transition from steatosis to steatohepatitis. J Physiol. 2017. Epub 2017 Jun 27. DOI: 10.1113/JP274281. PMID: 28504310 Enna, S.J. and Piette, J.G. Diamond Jubilee Special Issue: Celebrating 60 Years of Excellence. Biochemical Pharmacology doi:10.1016/j.bcp.2018.03.01, 2018. Enna, S.J. (Series Editor), David Kendall and Stephen P.H. Alexander (Volume Editors). Cannabinoid Pharmacology. Advances in Pharmacology, Vol. 80, Academic Press, United Kingdom, 475 pp. 2017. Enna, S.J. (Series Editor), Gavril Pasternak and Joseph T. Coyle (Volume Editors). A Tribute to Solomon H. Snyder. Advances in Pharmacology, Vol. 82, Academic Press, United Kingdom, 348 pp, 2018.

Enna, S.J. (Series Editor), Raouf A. Khalil (Volume Editor). Vascular Pharmacology: The Cytoskeleton and Extracellular Matrix. Advances in Pharmacology, Vol. 81, Academic Press, United Kingdom, 391 pp, 2018. Fletcher JA, Linden MA, Sheldon RD, Meers GM, Morris EM, Butterfield A, Perfield JW 2nd, Rector RS, Thyfault JP. Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic PGC- 1a deficient mice. Ex Physiol. 2018 Mar 1:103(3):4080418. Freitas N, Lukash T, Gunewardena S, Chappell B, Slagle BL, Gudima SO. "Relative abundance of the integrant-derived viral RNAs in infected tissues harvested from chronic HBV carriers". J Virol. 2018 Feb 28. pii: JVI.02221-17. doi: 10.1128/JVI.02221-17. [Epub ahead of print] PMID: 29491161 Fuller KNZ, Miranda ER, Thyfault JP, Morris JK, Haus JM. Metabolic derangements contribute to reduced sRAGE isoforms in subjects with Alzheimer’s Disease. Mediators Inflamm. 2018 Feb 22,2018. Gan L, Ma D, Li M, Yang F-C, Rogers RS, Wheatley JL, Koch LG, Britton SL, Thyfault JP, Geiger PC, Stanford JA (2018) Striatal PGC1-α and other markers of mitochondrial biogenesis are related to intrinsic aerobic capacity and are responsive to acute high fat diet exposure. Neurosci Lett 674, 49-53 Gan L, Ma D, Li M, Yang FC, Rogers RS, Wheatley JO, Koch LG, Britton SL, Thyfault JP, Geiger PC, Stanford JA. Region-specific differences in bioenergetics protein and protein response to acute high fat diet in brains of low and high capacity runner rats. Neurosci Lett. 2018 May 1:674:49-53. Graham A, Holbert J, Nothnick WB (2017) miR-181b-5p modulation of TIMP-3 expression during in vitro decidualization of a human endometrial stromal cell line and identification of miR-181b-5p targets by differential in-gel analysis. Reprod Sci. 24: 1264-1274. Heidker, RM, Emerson, MR, and LeVine, SM (2017) Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis. Neur. Regen. Res. 1 2:1262-1267. Review Hung WT, Navakanitworakul R, Khan T, Zhang P, Davis JS, McGinnis LK, Christenson L.K. Stage-specific follicular extracellular vesicle uptake and regulation of bovine granulosa cell proliferation. Biol Reprod. 2017 Oct 1;97(4):644-655. doi:10.1093/biolre/iox106. PMID: 29025042 Hutfles LJ, Wilkins HM, Koppel SJ, Weidling IW, Selfridge JE, Tan E, Thyfault JP, Slawson C, Fenton AW, Zhu H, Swerdlow RH. A bioenergetics systems evaluation of ketogenic diet liver effects. Appl Physiol Nutr Metab. 2017 Sep:42(9):955-962. J.A. Fletcher, M.A. Linden, R.D. Sheldon, G.M.E. Meers , E. Matthew Morris, A. Butterfield, J.W. Perfield 2nd, R.S. Rector, J.P. Thyfault. Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic PGC-1α deficient mice. Exp Physiol. 2018 Mar 1;103(3):408-418. DOI: 10.1113/EP086629. Epub 2018 Jan 16. PMID: 29215172. Jackson KL, Grames MS, Dayton RD, Stanford JA, Klein RL (2017) Methods and tips for intravenous administration of adeno-associated virus to rats and evaluation of transduction. JoVE. 126, e55994. Jarvis, M.F. and Enna, S.J. Editorial. Biochemical Pharmacology 151:143, 2018.

Keck J, Gupta R, Christenson L.K., Arulanandam BP. MicroRNA mediated regulation of immunity against gram-negative bacteria. Int Rev Immunol 2017 Aug 11:1-13. PMID: 28800263 Khristi V, Chakravarthi VP, Singh P, Ghosh S, Pramanik A, Ratri A, Borosha S, Roby KF, Wolfe MW, Rumi MAK. 2018 ESR2 regulates granulosa cell genes essential for follicle maturation and ovulation. Mol Cell Endocrinol 474:214-26. Khristi V, Chakravarthi VP, Singh P, Ghosh S, Pramanik A, Ratri A, Borosha S, Roby KF, Wolfe MW, Rumi MAK. 2018 Differentially regulated genes in Esr2-mutant rat granulosa cells. Data Brief 19:1008-11. Kim JM, Billington E, Reyes A, Notarianni T, Sage J, Agbas E, Taylor M, Monast I, Stanford JA, Agbas A (2018) Impaired Cu-Zn superoxide dismutase (SOD1) and calcinurin (Cn) interaction in ALS: A presumed consequence for TDP-43 and zinc aggregation in Tg SOD1G93A rodent spinal cord tissue. Neurochem Res. Jan 3. [Epub ahead of print]. Kim J, Choi IY, Duff K, Lee P. Progressive pathological changes in neurochemical profile of the olfactory bulbs and hippocampus of tau transgenic mice (rTg4510). Neurochem Res (2017) 42(6): 1649-1660. PMID: 28523532 Kumar D, Yalamanchali S, New J, Parsel S, New N, Holcomb A, Gunewardena S, Tawfik O, Lominska C, Kimler BF, Anant S, Kakarala K, Tsue T, Shnayder Y, Sykes K, Padhye S, Thomas SM. "Development and Characterization of an In Vitro Model for Radiation-Induced Fibrosis". Radiat Res. 2018 Jan 19. doi: 10.1667/RR14926.1. PMID: 29351058 Lee P, Adany P, Choi IY. Imaging based magnetic resonance spectroscopy (MRS) localization for quantitative neurochemical analysis and cerebral metabolism studies. Anal Biochem (2017) 529: 40-47. PMID: 28082217 PMCID: PMC5469694 Lee CY, Choi IY, Lee P. Perspective frequency correction using outer volume suppression-localized navigator for MR Spectroscopic Imaging. Magn Reson Med (2018) doi: 10.1002/mrm.27340. PMID: 29756324 Modaresi S, Kallem MS, Lee P, McIff TE, Toby EB, Fischer KJ. Evaluation of midcarpal capitate contact mechanics in normal, injured and post-operative wrists. Clin Biomech (2017) 47: 96-102. PMID: 28628801 PMCID: PMC5542399 Morris EM, McCoin CS, Allen JA, Gastecki ML, Koch L, Britton SL, Fletcher JA, Fu X, Ding WX, Burgess SC, Rector RS, Thyfault JP. Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis. J Physiol. 2017 Jul 15;595(14):4909-4926. Morris JK, Piccolo BD, Shankar K, Thyfault JP, Adams SH. The serum metabolomics signature of Type 2 Diabetes is obscured in Alzheimer’s Disease. AJP Endo and Metab. 2017 [Epub ahead of print]. Morris JK, Uy RAZ, Vidoni ED, Wilkins HM, Archer AE, Thyfault JP, Miles JM, Burns JM. Effect of APOE e4 genotype on metabolic biomarkers in aging and alzheimer’s disease. J Alzheimers Dis. 2017;58(4):1129-1135. Nielson CV, Duethman NC, Howard JM, Moncure M, Wood JG. Burns: Pathophysiology of Systemic Complications and Current Management. J of Burn Care Res, 38(1), e469-e481, 2017.

Norman GJ, Carlson JA, Patrick K, Kolodziejczyk JK, Godino JG, Huang J, Thyfault JP. Sedentary behavior and cardiometabolic associations in children 11-13 years of age. 2017 Child Obes. 2017 Oct:13(5):425-432. Nothnick WB, Falcone T, Joshi N, Fazleabas AT, Graham A. (2017) Serum miR-451a levels are significantly elevated in women with endometriosis and recapitulated in baboons (Papio anubis) with experimentally-induced disease. Reprod Sci. 24:1195-1202. Nothnick WB (2017) MicroRNAs and endometriosis: distinguishing drivers from passengers in disease pathogenesis. Sem Reprod Med. 35: 173 – 180. Nwachokor J, Tawfik O, Danley M, Mathur S, House J, Sharma P, Christenson LK, Bansal A. Quantitation of spatial and temporal variability of biomarkers for Barrett's Esophagus. Dis Esophagus. 2017 Sep 1;30(9):1-8. doi: 10.1093/dote/dox023 PMID: 28859356 Panasevich MR, Schuster CM, Phillips KE, Meers GM, Chintapalli SV, Wankhade UD, Shankar K, Butteiger DN, Krul ES, Thyfault JP, Rector RS. Soy compared with milk protein in a western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. J Nutr Biochem. 2017 Aug;46:125-136. Pessôa MTC, Alves SLG, Taranto AG, Villar JAFP, Blanco G, Barbosa LA. Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach. J Enzyme Inhib Med Chem. 2018 Dec;33(1):85-97. doi: 10.1080/14756366.2017.1380637 PMID: 29115894. Pohler KG, Green JA, Moley LA, Gunewardena S, Hung WT, Payton RR, Hong X, Christenson L.K., Geary TW, Smith MF. Circulating microRNAs as candidates for early embryonic viability in cattle. Mol Reprod Dev 2017 Aug;84(8):731-743. PMID: 28643872 Porter JW, Rowles JL, Fletcher JA, Zidon TM, Winn NC, McCabe LT, Park YM, Perfield JW, Thyfault JP, Rector RS, Padilla J, Vieira-Potter V. Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21. J Endocrinol. 2017 Nov;235(2):97-109. Stroh MA, Winter MK, McCarson KE, Thyfault JP, Zhu H. NCB5OR deficiency in the cerebellum and midbrain leads to dehydration and alterations in thirst response, fasted feeding behavior, and voluntary exercise in mice. Cerebellum. 2018 Apr:17(2):152:164. Syeda SS, Sánchez G, Hong KH, Hawkinson JE, Georg GI, Blanco G. Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception. J Med Chem. 2018 Mar 8;61(5):1800-1820. doi: 10.1021/acs.jmedchem.7b00925. Epub 2018 Jan 19. PMID: 29291372. Tan EP, McGreal SR, Graw S, Tessman R. Koppel SJ, Dhakal P, Zhang Z, Machacek M, Zachara NE, Koestler DC, Peterson KR, Thyfault JP, Swerdlow RH, Krishnamurthy P, DiTacchio L, Apte U, Slawson C. Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism. J Biol Chem. 2017 Sep 8;292(36):14940-14962. Velasquez SE, Abraham KJ, Burnett TG, Chapin B, Hendry WJ, Leung S, Madden ME, Rider V, Stanford JA, Ward RE, Chapes SK (2018). The K-INBRE Symposium: A 10-Institution Collaboration to Improve Undergraduate Education. Adv Physiol Edu 42, 104-110.

Yang F-C, Draper J, Smith PG, Vivian JL, Shapiro SM, Stanford JA (2018) Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non- Jaundiced Rat Brain. Cell Transplant 27, 654-665

b. Manuscripts in Press

A.E. Archer, R.S. Rogers, A.T. Von Schulze, J.L. Wheatley, E. Matthew Morris, C.S. McCoin, J.P. Thyfault, P.C. Geiger. Heat Shock Protein 72 Regulates Hepatic Lipid Accumulation. Am J Physiol Regul Integr Comp Physiol. Epub 2018 Jun 20. DOI: 10.1152/ajpregu.00073.2018. PMID: 29924632 Alali Z, Swan K, Nothnick WB. (2018) Matrix metalloproteinases and endometriosis pathophysiology. Current Women’s Health Reviews. 14:147 – 153. Bhattacherjee A, Mu Y, Winter MK, Knapp JR, Eggimann LS, Gunewardena SS, Kobayashi K, Kato S, Krizsan-Agbas D, Smith PG. Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in Rett Syndrome. Proceedings of the National Academy of Sciences USA, 2017 Aug 15;114(33):E6952-E6961. doi: 10.1073/pnas.1618210114. Epub 2017 Jul 31. Bhattacherjee A, Winter MK, Eggimann L, Mu Y, Gunewardena S, Liao Z, Christianson JA, and Smith PG. (2017) Motor, somatosensory, viscerosensory and metabolic impairments in a heterozygous female rat model of Rett syndrome. International Journal of Molecular Science 19(1). pii: E97. doi: 10.3390/ijms19010097. Chakrabarty A, Liao Z, Mu Y, and Smith PG. (2017) Inflammatory renin-angiotensin system disruption attenuates sensory hyperinnervation and mechanical hypersensitivity in a rat model of provoked vestibulodynia. Journal of Pain, 2018; 19(3):264-277. NIHMSID: NIHMS920763PMID: 29155208. PMCID: PMC5811351 Dalal K, Yu W, Ghosh S, Singh P, Wolfe M, Rumi MAK. 2017. Repression of p57KIP2 in trophoblast stem cells by SATB homeobox proteins. International Federation of Placenta Associations, Aug. 30-Sept. 2, Manchester, UK. Enna, S.J. (Series Editor), Kim Brosen and Per Damkier (Volume Editors). Pharmacogenetics. Advances in Pharmacology, Vol. 83, Academic Press, United Kingdom, in press. Khristi V, Singh P, Ghosh S, Pramanik A, Borosha S, Dalal K, Roby KF, Wolfe MW, Rumi MAK. 2017. Estrogen receptor 2 regulates the granulosa cell genes critical for gonadotropin induced preovulatory follicle maturation and ovulation. 14th Annual Gilbert S. Greenwald Symposium on Reproduction, Kansas City, KS. McCarson KE, Winter MK, Abrahamson DR, Berman NE, Smith PG. (2018) Assessing Repetitive Movement Behaviors in Rodent Models of Neurological Disorders. Neurobiology of Learning and Memory, S1074-7427(18)30045-5. doi: 10.1016/j.nlm.2018.02.025. Nothnick WB, Falcone T, Fazleabas AT, Olsen M, Tawfik OW, Graham A. (2018) Macrophage migration inhibitory factor receptor, CD74, is over-expressed in human and baboon (Papio Anubis) endometriotic lesions and modulates endometriotic epithelial cell survival and interleukin-8 Nothnick WB, Marsh C, Alali Z. (2018) Future directions in endometriosis research and therapeutics. Current Women’s Health Reviews. 14:189 – 194. Woo I, Christenson LK, Gunewardena S, Ingles SA, Thomas S, Ahmady A, Chung K, Bendikson K, Paulson R, McGinnis LK. Micro-RNAs involved in cellular proliferation have altered expression profiles in granulosa of young women with diminished ovarian reserve.J Assist Reprod Genet In Press

Yang FC, Draper J, Smith PG, Vivian JL, Shapiro SM, Stanford JA. Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain. Cell Transplant. 2018 Jan 1: 27(4):654-665. PMID: 29845869. PMCID: PMC6041884 Yu W, Dalal K, Ghosh S, Singh P, Wolfe M, Rumi MAK. 2017. Disruption of SATB signaling dysregulates BMP4 expression in trophblast stem cells. International Federation of Placenta Associations, Aug. 30-Sept. 2, Manchester, UK.

53 c. Abstracts

Bansal A, Aigner A, Christenson LK. 2018. MICRORNA NANOTHERAPEUTICS FOR ESOPHAGEAL ADENOCARCINOMA. DDW 2018. Brachova P, Alverez N, Latham K, Albertini D, and L.K. Christenson. 2017. A-to-I RNA editing in mammalian oocytes. 50th Annual meeting of Society for the Study of Reproduction, Washington, DC. Brachova P, Alverez N, Latham K, Albertini D, and L.K. Christenson. 2018. ADAR1 A- to-I RNA editing in oocytes alters codon usage. Keystone Mobile Genomic Meeting Santa Fe, Utah. Chakrabarty A, Liao Z, Rumi KM, Smith PG (2018) Estrogen receptor Esr1 is required for development of hypersensitivity and hyperinnervation in a rat model of vestibulodynia. World Congress on Pain, Boston MA Choi I-Y, Lee P, Hughes AJ, Adany P, Belliston S, Denney DR and Lynch SG. The relationship between oxidative stress and symptoms of fatigue and depression in multiple sclerosis: a pilot study. Mult Scler (2017) 23(S3):547. 33rd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and 7th Joint ECTRIMS-ACTRIMS meeting, Paris, France, October 25-28, 2017. – poster presentation Christenson L.K., Hong H, Alwood JS, Rocca AE, Tash JS. 2017. Development of a Novel Space Flight Plan to Monitor Female Mice Fertility Using Reduced Crew Time. American Society of Gravitational and Space Research, Seattle, WA. October 25-28, 2017. Chrysikou EG, Hanson GK, Ramey CH, Martin LE, Choi I-Y, Lee P and Brooks WM. Transcranial direct current stimulation effects on prefrontal cortex in major depressive disorder (MDD) measured by in vivo proton magnetic resonance spectroscopy (1H MRS). Brain Stimulation (2017) 10:e53-e54. 3rd Biennial International Meeting on Neuromodulation (NYC Neuromodulation), New York, NY, January 13-15, 2017. - poster presentation De A, Zhou J, Sharma M, Gunewardena S, Christenson LK, Bansal A. FORKHEAD BOX F1 (FOXF1) CAN NOT ONLY INDUCE A BARRETT’S ESOPHAGUS LIKE METAPLASTIC CHANGE BUT ALSO INDUCE MALIGNANT BEHAVIOR IN NORMAL ESOPHAGEAL CELLS. DDW 2018. Emily Paprocki, D.O., Kelsee Halpin, M.D., Leslie Heckert Ph.D., Jill Jacobson, M.D. “Clinical and Biochemical Findings of Hyperandrogenism in Non-Obese and Obese Transgender Male Youth” Annual Meeting of the Pediatric Endocrine Society. May 5-8, 2018 - Toronto, Canada Emily Paprocki, D.O., Kelsee Halpin, M.D., Leslie Heckert Ph.D., Jill Jacobson, M.D. Establishing New Growth Charts in Transgender and Gender Non-Binary Adolescents on Standard Gender Affirming Therapy. 100th Annual Meeting of the Endocrine Society. March 17-20, 2018 Chicago, Illinois Lee C-Y, Choi IY and Lee P. Prospective frequency correction using outer volume suppression-localized navigator for MR Spectroscopic Imaging. Proc Int Soc Magn Reson Med 25 (2017) 5526. Honolulu, HI, April 22-27, 2017. - electronic multimedia poster presentation

Lee CY, Choi IY, Lee P. In vivo validation of OVS-localized navigator for prospective frequency correction in MRSI, Proc Int Soc Magn Reson Med 26 (2018) 1311. Paris, France, June 16-21, 2018. - electronic poster presentation Lee CY, Choi IY, Lee P. Retrospective frequency correction for fluorine (19F) MRS using an external reference, Proc Int Soc Magn Reson Med 26 (2018) 3884. Paris, France, June 16-21, 2018. - electronic poster presentation Lee P, Lee CY, Choi I-Y, Lynch SG, Huisinga JM. Correlation between sensorimotor delay and microstructural integrity of the spinal cord in multiple sclerosis. Mult Scler (2017) 23(S3):1018. – 33rd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and 7th Joint ECTRIMS-ACTRIMS meeting, Paris, France, October 25-28, 2017. - poster presentation E. Matthew Morris, Alex Von Schulze, Julie Allen, Colin McCoin, John Thyfault. Impact of Reduced Liver Mitochondrial Function on Intermittent HFD-induced Adiposity in Young Mice. The Obesity Society Annual Meeting at ObesityWeekSM 2017; October 29 – November 2, 2017; Washington, DC. www.obesityweek.com. Gladis Sánchez, Jeff P. McDermott and Gustavo Blanco. Ouabain enhances the cystic phenotype of the kidney in a mouse model of ADPKD. P-Type-ATPase Meeting, Otsu, Japan, September 2017. Jeff P. McDermott, Gladis Sánchez and Gustavo Blanco. Mutation of the Na,K-ATPase α4 isoform ouabain site does not affect sperm fertilizing capacity. American Society of Andrology. Miami, April 2018. Jeff P. McDermott, Gladis Sánchez, Liu Lijun and Gustavo Blanco. Na,K-ATPase α4, but not α1 is essential for sperm function, but its ouabain binding site is not required for male fertility. P-Type-ATPase Meeting, Otsu, Japan, September 2017. Laura Kutz, Shreya Mukherji, Pauline Marck, Xiaoyu Cui, Judith Heiny, Gustavo Blanco, Sandrine Pierre, and Zijian Xie. Isoform-Specific Role of Na/K-ATPase α1 in Skeletal Muscle Growth and Performance. Experimental Biology, Chicago, IL, April 2017. Pan, X, Sands, SA, Yue, Y, Zhang, K, LeVine, SM*, and Duan, D*. Vector optimization dramatically improved the outcome of Krabbe disease gene therapy in the twitcher mouse model. ASGCT 21st Annual Meeting in Chicago, IL, May 16‐19, 2018. Molecular Therapy 2018; 26(5):260 Pauline Marck, Xiaoliang Wang, Laura Kutz, Xiaoyu Cui, Gustavo Blanco, Liquand Cai, Zijian Xie and Sandrine V. Pierre. Cardiac structure and function in mice with a cardiomyocyte-specific knockout of Na+/K+-ATPase α1-isoform. Experimental Biology, Chicago, IL, April 2017. Preet R, Hung WT, Vishwakarma V, Christenson LK, Dixon DA. 2018. THE RNA BINDING PROTEIN HuR REGULATES EXTRACELLULAR VESICLE SECRETION IN COLORECTAL CANCER. DDW 2018. Stanford JA, Stanford KG, Rogers RS, O’Meara B, Hong Y, Nishimune H (2017). Effects of long-term forelimb resistance training on neuroprotective proteins in the brains of aged rats. Poster presented at the 47th Annual Meeting of the Society for Neuroscience in Washington, D.C.

Yang, F-C, Riordan SM, Vivian, JL, Shapiro, SM, Stanford, JA (2017). Neural progenitor cell survival and neuritic outgrowth after transplantation into jaundiced and nonjaundiced rat brain. Poster presented at the 24th Annual Meeting of the American Society for Neural Therapy and Repair in Clearwater Beach, FL. Yang F-C, Riordan SM, Vivian JL, Shapiro SM, Stanford JA (2017) Time course of neural progenitor cell survival and development after transplantation into jaundiced rat brain. Poster presented at the 47th Annual Meeting of the Society for Neuroscience in Washington, D.C.

RESEARCH SUPPORT

V.G. Blanco: NIH: “Inhibitors of Na, K-ATPase alhpha4 as male contraceptives” April 1st, 2014 – March 31st, 2019. Annual Direct Costs: $190,000

NIH: “Kansas IDeA Network of Biomedical Research Excellence” May 15th, 2014 – April 30th, 2019. Annual Direct Costs: $20,000

NASA: “Space flight-altered motility activation and fertility-dependent responses in sperm from sea urchin and rodents” March 30th, 2017 – April 1st, 2019. Annual Direct Costs: $170,000

V.M. Chennathukuzhi: NIH/NICHD: “The role of REST in the pathogenesis of uterine fibroids (Role: PI)” 2013- 2019. Annual Direct Costs: $238,042

NIH/NIHCD: “Inhibitors of Ne, K-ATPase alpha4 as male contraceptives (Role:Co-I)” 2014-2019. Annual Direct Costs: $182,000

NIH/NICHD: “Small molecule GPR10 antagonists for the treatment of uterine fibroids (Role:PI)” August 8th, 2018 – July 31st, 2020. Annual Direct Costs: $210, 547

NIH/NICHD: “Cell-cycle regulatory kinases as targets for male contraceptives drug development (Role:PI)” 2014 – 2019. Annual Direct Costs: $224, 775

L.K. Christenson: NASA: “Female reproductive health: Space flight induced ovarian and estrogen signaling dysfunction, adaptation, and recovery” November 1st, 2014 – October 31st, 2021. Annual Direct Costs: $250,000

NIH: “Macrophage-derived Extracellular Vesicles and Pulmonary Vascular Remodeling” July 1st, 2016 – June 30th, 2021. Annual Direct Costs: $250,000

NIH-R01: “Mitochondrial RNA defense pathways in the oocyte” February 1st, 2018 – January 21st, 2023” Annual Direct Costs: $289,000

S.J. Enna: NIH: “Kansas University Training Program in Neurological and Rehabilitation Sciences (Nudo, P.I., Enna, Co-Director)” May 2014 – April 2019. Annual Direct Costs: $266,000

Elsevier: “Editorial Office, Biochemical Pharmacology and Pharmacology & Therapeutics” 2004 – 2020. Annual Direct Costs: $140,000

International Union of Basic and Clinical Pharmacology: “Society Office” 2006 – 2018. Annual Direct Costs: $52,500

P.C. Geiger: NIH/NIGMS Centers of Biomedical Research Excellence(COBRE): “The HSF1-PGC1a-HSP72 transcriptional axis maintains mitochondrial health and liver metabolism” 2017 – 2019. Annual Direct Costs: $60,000

American Physiological Society Research Career Enhancement Award: “Heat therapy and vascular function training” 2 – 17 – 2019. Annual Direct Costs: $19,505

KUMC ADC: “Targeting the heat shock response to maintain proteostasis and lower risk for Alzheimer’s Disease” 2018 – 2019. Annual Direct Costs: $16,000

KUMC Department of Anesthesiology: “Heat therapy for fibromyalgia: the effect on chronic pain and possible mechanisms” 2018 – 2019. Annual Direct Costs: $7,000

L.L. Heckert: NIH: “The XXIVth North American Testis Workshop” April 1st, 2017 – March 31st, 2018. Annual Direct Costs: $6,000

S.M. LeVine: ApoPharma, Inc.: “Continuation for: Iron Chelation in Experimental Autoimmune Encephalomyelitis” June 1st, 2017 – March 31st, 2019. Annual Direct Costs: $71,400

National Multiple Sclerosis Society: “High Dose Biotin Therapy and Remyelination” November 1st, 2017 – October 31st, 2018. Annual Direct Costs $40,000

E.M. Morris: NIH/NIDDK: “Hepatic mitochondrial function control of high-fat diet- induced weight gain” September 8th, 2017 – September 7th, 2022. Annual Direct Costs: $147, 889

KINBRE: “Reduced liver metabolism modulates neural development impacting obesity risk” May 1st, 2018 – April 30th, 2018. Annual Direct Costs: $75,000

W.B. Nothnick: NIH: “60S acidic ribosomal protein P1 and endometriosis pathogenesis” August 1st, 2017 – May 31st, 2018. Annual Direct Costs $125,000

NIH: “The role of REST in the pathogenesis of uterine fibroids” August 1st, 2013 – July 31st, 2018.

P.G. Smith: NIH: “Identifying therapeutic targets for vulvodynia” July 1st, 2012 – June 30th, 2017. Annual Direct Cost: $260,000

KUEA: “Spinal Cord Injury Repair Program” April 15th 2011 – April 14th 2018. Annual Direct Cost: $400,000

NIH: “Creation and characterization of models of a BLHLB9 developmental disorder” April 1st, 2015 – June 30th, 2017. Annual Direct Cost: $135,000

NIH: “High Throughout Sequencing System for KUMC Genomics Core” February 1st, 2016 – January 31st, 2017. Annual Direct Cost: $493,000

NIH: “Kansas Intellectual & Developmental Disabilities Research Center (KIDDRC)” September 26th, 2016 – June 30th, 2021. Annual Direct Cost: $380,000

J.A. Stanford: Children’s Merc Hospital: “Preclinical studies of bilirubin encephalopathy” June 1st, 2013 – August 31st, 2019. Annual Direct Costs: $100,000

NIH: “Exercise- activated mechanisms reduce degeneration of aged neuromuscular junctions” September 30th, 2015 – May 31st, 2020. Annual Direct Costs: $1,959,385

J.S. Tash: NIH – “H2-Gamendazole analogues as reversible non-hormonal male contraceptive agents.” September 01, 2012 – June 30, 2017.

NIH: “Cell-cycle regulatory kinases as targets for male contraceptive drug development.” April 1, 2014 – March 31, 2019.

NASA: “Space flight-altered motility activation and fertility-dependent responses in sperm from sea urchin and rodents.” August 1, 2013 – March 31, 2019.

NASA: “Female reproductive health: Space flight induced ovarian & estrogen signaling dysfunction, adaptation, and recovery.” November 1,2014 – January 31, 2019.

J.Thyfault: NIH: “Stains, Mitochondrial Function, and Aerobic Capacity” July 20th, 2017- July 19th, 2022. Total cost over 5 years: $3,041,884

NIH: “Skeletal muscle mitochondrial Abnormalities in Alzheimer’s Disease” May 1st, 2017- April 31st, 2019. Total cost over 2 years: $420, 750

Veterans Affair Merit Review: “Mitochondrial Abnormalities in Alzheimer’s Disease” October 1st, 2014 – September 31st, 2018. Total cost over 4 years: $961,328

NIH: “Increased Protein at Breakfast for Weight Management in Overweight Adolescents” October 1st, 2016 – September 31st, 2021

NIH: “Mechanisms Regulating Autophagy in Alcohol- Induced Liver Injury” July1st, 2017 – June 201th, 2022

N. Wang: NICHD: “Molecular and functional hier” July 2018 – June 2019. Annual Direct Cost: $136,046

M.W. Wolfe: NIH: Stem cells and epigenetics of trophoblast lineage development” July 2014 – June 2019. Annual Direct Cost: $733,408

J.G. Wood: NIH: “Teacher and students for community-oriented research and education (T-SCORE)” February 1st, 2016 – January 30th, 2020. Annual Direct Cost: $200,000

Academy of Medical Educators: “Interactive, personalized and flipped classroom stimulation experiences utilizing hemodynamic monitoring for medical education” 2017 – 2018. Annual Direct Cost: $10,750

ACTIVITIES OF FACULTY

Andrei B. Belousov, Ph.D., Associate Professor

We are interested in the mechanisms of regulation of neuronal gap junctions (electrical synapses) during development and neuronal injury. We also study the role of neuronal gap junctions in death of neurons in the developing nervous system and in the secondary, glutamate-dependent neuronal death following ischemic stroke, traumatic brain injury and epilepsy. As a result of these studies, a novel model of the mechanisms of glutamate-dependent neuronal death has been proposed, where neuronal gap junctions play a critical role.

Committee Activities: KUMC Physiology Department Representative, KUMC Faculty Council Information Resource Committee, KUMC Member Community Student Research Forum, KUMC Judge Resident, Postdoc, and Fellow Research Forum, KUMC Judge Student Committee Service Member, Ph.D. dissertation committee, Page Hayley Community Greater Kansas City Chapter of the SFN, Member

Editorial and Grant Reviews: Ad Hoc Reviewer, Cellular and Molecular Neurobiology Ad Hoc Reviewer, Frontiers in Molecular Neuroscience Ad Hoc Reviewer, Neuroscience Letters Ad Hoc Reviewer, Journal of Neuroscience Research Ad Hoc Reviewer, Pharmacology and Therapeutics Ad Hoc Reviewer, Neuropharmacology Ad Hoc Reviewer, OncoTargetAd hoc Reviewer, Frontiers in Cellular Neuroscience Ad hoc Reviewer, NTRC study section, NIH Grant Reviewer, KUMC, Research Institute Clinical Pilot Grants Reviewer, Abstracts for the International Stroke Conference, American Heart Association Lied Basic Science Grants, KUMC Reviewer, Mallinckrodt Foundation, KUMC

Teaching Activities: PHSL 842 – Comprehensive Human Physiology 9 – 2 hour lectures IGPBS – Cellular Structure 2 – 2 hour lectures 1 – 2 hour seminar

Dr. Belousov (continued)

B2.021- Altered mental status in an elderly patient 1 – 1 hour lecture B5.072- CBCL: Malabsorption syndrome 1 – 1 hour lecture CBCL 8 – 2 hour lectures

Research Personnel: Janna V. Belousova, M.S., Senior Research Associate

V. Gustavo Blanco, M.D., Ph.D., Professor & Kathleen M. Osborn Chair

Our laboratory studies the role of ion-transport proteins of the plasma membrane in cell function, with a particular emphasis on the Na,K-ATPase. The Na,K-ATPase or Na pump is an enzyme of the cell plasma membrane, that uses ATP to transport cytoplasmic Na+ out of the cell in exchange for extracellular K+. Structurally, Na,K- ATPase is composed of a catalytic α and an associated β subunit. In mammals, different molecular variants or isoforms of the α (α1, α2, α3 and α4) and a β (β1, β2 and β3) polypeptide are expressed in a tissue and cell dependent manner. Our work has shown that different isoforms of the Na,K-ATPase have enzymatic properties that are unique and that they are not biologically redundant. While the ubiquitously expressed Na,K-ATPase α1 and β1 functions as the housekeeping Na,K-ATPase in the cell, the other isozymes mediate tissue-specific roles. We have identified α4 as a catalytically active isoform of the Na,K-ATPase, which is only expressed in testis male germ cells and is abundant in the sperm flagellum. Using pharmacological tools and genetic approaches in transgenic mice, we have established that Na,K-ATPase α4 is essential for sperm motility and male fertility. We are currently continuing experiments to understand the mechanisms of action and regulation of α4, with the idea of using it as a biomarker for male fertility and a target for male contraception. In addition, we are studying the role of the Na,K-ATPase in autosomal dominant polycystic kidney disease (ADPKD). ADPKD is characterized by the progressive enlargement of fluid filled cysts in the kidneys that compromise the function of the organ. We have found that the hormone ouabain, acting via the Na,K-ATPase α1 stimulates renal cyst formation and progression in ADPKD. We continue experiments to understand the role and mechanisms of action of ouabain in ADPKD, with the idea of finding approaches to slow ADPKD cystogenesis.

Meetings Attended: September 2017 – P-Type-ATPase Meeting, Otsu, Japan October 2017 – U54 and U01 Steering Committee Meeting. Bethesda October 2017 – Greenwald Symposium in Reproduction, KUMC December 2017 – Association of Chairs of Departments of Physiology, Jamaica

Committee Activities: Departmental Kathleen M. Osborn Chair, Department of Molecular & Integrative Physiology Co-Director, Thesis Committee, Archana Raman, Physiology, Ph.D. Member, Thesis Committee, Pei-Lei, Physiology, Ph.D. Member, Thesis Committee, Felcy Selwyn, Pharmacology, Ph.D. Member, Thesis Committee, Wen Zhao, Pharmacology, Ph.D. Member, Thesis Committee, Kelli Boxberger, Pharmacology, Ph.D. Member, Thesis Committee, Yuchen Zhang, Pharmacology, Ph.D. Member, Thesis Committee, Younshim Park, Physiology, Ph.D. Member, Thesis Committee, Zahraa Alali, Physiology, Ph.D.

Dr. Blanco (continued)

Member, Thesis Committee, Shreya Mukherji, Pharmacology, Ph.D., Marshall University Member, Thesis Committee, Minqi Huang, Pharmacology, Ph.D., Marshall University KUMC Director, K-INBRE Developmental Research Core (DRPP Core) Member, Wescoe Society, serving as a mentor for medical students Member, M.D./Ph.D. Admission Committee Program, helping to interview and select students Member, Committee for the University Biotechnology Sequencing Facility Member, Committee member for the organization of the Greenwald Symposium Member, Wescoe Academic Society Member, Review Committee for Pilot Grant Program of the Liver Disease COBRE Member, KUMC Strategic Planning Committee Member, K-INBRE Incentive and Awards Committee

Editorial and Grant Reviews: Grant Review, K-INBRE research grants Grant Review, Lied Basic Science Pilot Grants, KUMC Reviewer, American Journal of Physiology – Metabolism and Endocrinology Section Reviewer, Journal of Assisted Reproduction and Genetics Reviewer, Frontiers in Reproduction Ad Hoc Reviewer, Journal of American Journal of Physiology – Endocrinology Ad Hoc Reviewer, Journal Assisted Reproduction and Genetics Ad Hoc Reviewer, American Journal of Physiology Ad Hoc Reviewer, Biology of Reproduction

Invited Presentations: September 2017 – G. Blanco. Relative contribution of Na,K-ATPase α4 and Na,K-ATPase α1 isoforms to sperm motility. The 15th International Conference on Na,K-ATPase and Related Transport ATPases, Otsu, Japan September 2017 – G. Blanco. Na,K-ATPase α4, but not α1 is essential for sperm function, but its ouabain binding site is not required for male fertility. The 15th International Conference on Na,K-ATPase and Related Transport ATPases, Otsu, Japan October 2017 – Gladis Sanchez, Shameen Sultana Syeda, Kwon Ho Hong, Gunda Georg and Gustavo Blanco. Cardenolide inhibition of the sperm- specific Na,K-ATPase α4 for male contraception. U54 Steering Committee. New York

Dr. Blanco (continued)

November 2017 – G. Blanco. “Na,K-ATPase α4: the ion transporter that propels sperm and drives sperm fertility”, Northwestern University, Chicago IL January 15, 2018 – K-INBRE Annual Symposium. Developmental Research Core. Overland Park, Kansas April 2018 – K-INBRE External Advisory Committee. KUMC May 2018 – G. Blanco. Thesis defense evaluation for Hang Nielse “Mutational studies of the mechanisms of ion binding and PKA regulation of the Na+,K+-pump”, Aarhus University, Aarhus, Denmark

Seminars Presented: November 2017 – G. Blanco. “Na,K-ATPase α4: the ion transporter that propels sperm and drives sperm fertility”, Northwestern University, Chicago IL November 2017 – G. Blanco. Na,K-ATPase mediated pro-cystogenic effects of ouabain in autosomal dominant polycystic kidney disease. Marshall University, Huntington WV May 2018 – G. Blanco. The testis specific Na,K-ATPase. Marine Biological Laboratories, Woods Hole, MA

Academic Honors: Students Voice Award for Excellence in Teaching

Teaching Activities: CORE 825 – Renal Physiology 18 – 1hour sessions Integration and Consolidation – Renal Insufficiency 1 – 2 hour session Remediation Course- Renal Physiology 2 – 3 hour sessions Step Prep Course- Renal Physiology 1 – 1 hour session CBCL- Renal Failure, Diabetes insipidus, Renal arterial stenosis 1 – 1 hour session Nephrology Fellow Boards– Clinical Renal Physiology 4 – 1 hour sessions Medical Curriculum 7 – 2 hour sessions Prematriculation Hemorrhagic shock, myocardial infarction 2 – 2 hour sessions IGPBS, Membrane biology and transport 3 – 6 hour sessions Frontiers of Reproduction 2 – 16 hour sessions Human Physiology 3 – 2 hour sessions

Dr. Blanco (continued)

Physiology of Disease 3 – 2 hour sessions

Research personnel: Gladis Sanchez M.D., Research Associate Jeff McDermott, Senior Research Associate Marco Tulio Correa Pessoa, visiting Ph.D. student Abdouli Njai, undergraduate student

Vargheese M. Chennathukuzhi, Ph.D., Associate Professor

My research interests include uterine fibroid pathogenesis, fertility and contraception. Uterine fibroids are the most common tumors of the female reproductive tract and are the leading indication for hysterectomies in the US. Sadly, there is no approved drug to treat uterine fibroids chronically. Our laboratory is trying to understand the regulation and function of GPR10, a G protein-coupled receptor, aberrantly expressed in uterine fibroids. We have generated transgenic mice overexpressing GPR10 in the myometrium in order to understand its role in the pathogenesis of fibroids. Transgenic-hGPR10 mice develop uterine fibroids that are phenotypically identical to the human disease. We plan to use this preclinical model for the development of small molecule modulators of GPR10 as treatment for fibroids. In addition, we have identified the molecular machinery that regulates aberrant expression of GPR10 in uterine fibroids. We recently developed a conditional knockout model for Rest, the transcriptional repressor of GPR10. Rest cKO mice develop uterine fibroid phenotype. We have also identified PRICKLE1 as the upstream regulator of REST stability and function in the uterus. Our laboratory is trying to validate the role of environmental estrogens in the suppression of Prickle1 gene and REST protein expression using rodent models.

Our laboratory is also interested in molecules that regulate sperm function and male fertility. We have an ongoing project to identify small molecule inhibitors of CDK2 that specifically inhibit meiosis, as potential contraceptive drugs. We are also studying the functional regulation of the sperm specific sodium-proton exchanger (sNHE) in expression systems that utilize chimeric channels.

Committee Activities: Departmental Member, Finance Committee Member, GSAC Coordinator, Physiology Seminar Series Member, Faculty Search Committee Student Service Committee Member, Thesis Committee, Zahraa Alali, Physiology, Ph.D. Member, Thesis Committee, Younshim Park, Physiology, Ph.D. Member, Thesis Committee, Wei-Ting Hung, Physiology, Ph.D. Member, Thesis Committee, Saieed Safder, Microbiology, Ph.D. Member, Thesis Committee, Ashley Ward, Physiology, Ph.D. Member, Thesis Committee, Brittany Jack, Anatomy and Cell Biology, Ph.D. KUMC Member, Faculty Council Member, D3ET (Drug Discovery, Delivery and Experimental Therapeutics), IAMI Member, IGPBS Admissions Committee Community Chair, SSR Awards Committee

Dr. Chennathukuzhi (continued)

Editorial and Grant Reviews: Ad Hoc Reviewer, Integrative and Clinical Endocrinology and Reproduction (ICER) study section (ad hoc) Ad Hoc Reviewer, CMIR Study section 6/21/2017 Ad Hoc Reviewer, Biology of Reproduction, PLOS One, Human Reproduction Member, Endocrine and Reproductive Biology Special Emphasis Panel/Scientific Review Group 2017/10 ZRG1 EMNR-V (02) M) Member, Special Emphasis Panel/Scientific Review Group ZHD1 DSR-L (50) Member, Special Emphasis Panel/ Scientific Review Group 2018/01 ZHD1 DSR- L (50)1

Seminars Presented: November 6th, 2017 – “The loss of REST in uterine fibroids” Wichita State University

Teaching Activities: PHSL 834 – Reproductive Physiology Course Director 3 – 2 hour sessions IGPBS Genetic Switches-Gene Expression 3 – 2 hour sessions PHSL 842 – Comprehensive Human Physiology 2 – 2 hour sessions PHSL 843 – Physiology of Disease 2 – 2 hour sessions CBCL- Small Group Facilitation 7 – 2 hour group sessions

Research personnel: Faezeh Koohestani, Ph.D. (Postdoctoral Fellow): The Role of REST in the pathogenesis of uterine fibroids – Accepted a science and marketing manager position at GenScript. Michelle McWilliams (Graduate Student): Estrogenic regulation of PRICKLE1 and its effect on REST in uterine fibroids – Submitted the graduate thesis, defended and graduated with Ph.D. in Physiology during the year- Accepted the position of Research Scientist at Charles River, Reno, NV Mina Farahbakhsh (M.D./Ph.D. Graduate Student): Role of ADAM12 and other REST target genes in uterine fibroids – Submitted the graduate thesis, defended and graduated with Ph.D. in Physiology during the year. Currently back in clinical rotations at KUMed. Ashley Cloud (IGPBS Rotation Student): Spring 2017, Current Graduate Student Sornakala Ganeshkumar (Research Assistant) Kavya Shivashankar Undergraduate Student, Columbia, NY – Joined recently in the M.D. program of Thomas Jefferson University, Philadelphia, PA

Dr. Chennathukuzhi (continued)

Abril Lara (Gear UP Summer Intern, June – Aug 2017) Ganesh Aruna (Summer Intern June – Aug 2017) Currently undergraduate student at Vanderbilt India Barnett (Gear UP Summer Intern, June – Aug 2018)

Lane K. Christenson, Ph.D., Associate Professor

Fertility, infertility and ovarian cancer are major health concerns for women. Research in my laboratory focuses on understanding the terminal events involved in follicular development and ovulation. The studies have direct implications in development of a fertile healthy oocyte, contraception and disease conditions such as polycystic ovarian syndrome and ovarian cancer. Current studies focus on understanding the role extracellular vesicles (exosomes and microvesicles) play in ovarian function (oocyte maturation, granulosa cell function) and in ovarian cancer. The laboratory is also examining how post-transcriptional regulatory processes such as RNA editing impacts oocyte developmental competence. These studies use the latest state of the art technologies, including next-gen-sequencing, nanoparticle analysis in addition to standard molecular and biochemical techniques. The laboratory also uses a comparative approach using human, bovine and murine cells and animal studies in both cows and mice to gain further insights into the reproductive biology of the ovary.

Committee Activities: Departmental Member, Greenwald Symposium Planning Committee Early Development Theme Leader, KIDDRC Member, Departmental Finance Committee Member, Departmental Faculty Search Committee Student Service Committee Chair, Advisory and Dissertation Committee, Rikki Nelson, Physiology, Ph.D. Member, Advisory and Dissertation Committee, Zahraa Alali, Physiology, Ph.D. Member, Advisory and Dissertation Committee, Jonathon Keck, Immunology, Ph.D. University of Texas San Antonio Member, Advisory and Dissertation Committee, Greg Burns, Ph.D., University of Missouri Member, Advisory and Dissertation Committee, Jianzheng Wu, Physiology, Ph.D. Member, Advisory and Dissertation Committee, Hope Waisner, Microbiology, Ph.D. KUMC Member, Freezer Monitor Committee, SOM Member, Genomics Core, KINBRE Member, Human Stem Cell Research Oversight Committee National Director on SSR Board, Society for Study of Reproduction Program Committee

Dr. Christenson (continued)

Editorial and Grant Reviews: Reviewer, National Institute of Health- Reproduction, Andrology and Gynecology Study Section 2015 – 19 – Permanent member Ad Hoc Reviewer, Grant, Welcome Trust/DBT India Alliance Fellowship Ad Hoc Reviewer, Grant, United States/ Israel Binational Science Foundation Grant Reviewer, Member, NIH- P50 Special Review Panel Editorial Board Member, Journal of Assisted Reproduction and Genetics Reviewer Editorial Board of Reproductive Endocrinology, Frontier in Endocrinology Office/ Advisory Groups: Director on SSR Board (Nationally Elected), Society for Study of Reproduction

Invited Presentations: July 15, 2017 – Society for Study of Reproduction - Cellular Communication with the Ovarian Follicle – Extracellular Vesicles Is There a Role? Symposium Session – Control of Ovarian Development, Washington, DC May 18, 2018 – Annual Michigan Alliance for Reproductive Technologies and Sciences – RNA editing in Oocyte and Ovarian Function. Grand Rapids, MI

Teaching Activities: Frontiers in Reproduction at Marine Biology Laboratory- Tole of RNA editing in ovarian function 1 – 2 hour session MI CBCL 6 – 2 hour sessions IGPBS 3 – 2 hour sessions PHYS 842 1 – 2 hour session

Meetings Attended: July 15, 2017 – Society for Study of Reproduction, Washington DC October 3, 2017 – American Society for Gravitational and Space Research, Seattle, WA

Research personnel: Pavla Brachova – (NRSA- Completed) Post-Doctoral Fellow Xiaoman Hong – Senior Research Associate Jake Cushing – Research Technician Rikki Nelson – Ph.D. Student Lauren Stubbs – Undergraduate Volunteer Tyler Elmendorf – Undergraduate KINBRE Summer Scholar

Salvatore J. Enna, Ph.D., Professor, Associate Dean for Research and Graduate Education

Neurotransmitters and neurotransmitter receptors, with particular emphasis on the structure, function and pharmacology of GABA receptors.

Meetings Attended: July 13 – 15, 2017 – Reference Module in Biomedical Sciences Editorial Board Meeting, Oxford, United Kingdom, July 13-15, 2017. August 6 – 8, 2017 – Nebraska INBRE Conference, Nebraska City, Nebraska September 16 – 17, 2017 – Current Protocols in Pharmacology Editorial Board Meeting, Philadelphia, Pennsylvania September 27 – 29, 2017 – ICMAN Natural Products Conference, Aberdeen, United Kingdom October 28 – 29, 2017 – International Union of Basic and Clinical Pharmacology (IUPHAR) Executive Committee Meeting, Rimini, Italy October 25 – 28, 2017 – Italian Society of Pharmacology Congress, Rimini, Italy November 1 – 3, 2017 – PhRMA Foundation Grant Review Meeting, Washington, D.C., December 3 – 7, 2017 – American College of Neurophsychopharmacology Meeting, Palm Springs, California March 7 – 10, 2018 – Neurotherapeutics Discovery and Development for Academic Scientist Course, Rockville Maryland April 21 – 25, 2018 – Experimental Biology, American Society for Pharmacology and Experimental Therapeutics Annual Meeting, San Diego, California May 15 – 20, 2018 – Pharmacology Futures and NC-IUPHAR Committee Meetings, Edinburgh, United Kingdom

Committee Activities: Departmental Chair, Departmental Appointments, Promotions, and Tenure Committee KUMC Internal Advisory Committee (Co-Chair), Kansas University Training Program in Neurological and Rehabilitation Sciences Member, Executive Research Committee Member, Faculty Activity Collaborative Tool (FACT) Committee Member, Medical School Extended Dean’s Committee

National Chair, Nebraska-INBRE External Advisory Committee Member, PhRMA Foundation Pharmacology Advisory Panel Member, British Pharmacological Society International Advisory Group Member, GABA-B Nomenclature Database Committee Member, UMKC School of Pharmacy Research Advisory Council

Dr.Enna (continued)

International President, International Union of Basic and Clinical Pharmacology (IUPHAR) Member, International Union of Basic and Clinical Pharmacology (IUPHAR) Executive Committee

Editorials and Grant Reviews: PhRMA Foundation Pharmacology/Toxicology Grant Review Committee Editorial Advisory Board, CNS Drug Review Editorial Advisory Board, Current Opinion in Pharmacology Editorial Advisory Board, Chinese Medicine Editorial Advisory Board, Pharmacology International

Editorial Boards of Scientific Journals: Editor-in-Chief, Biochemical Pharmacology Executive Editor-in-Chief, Pharmacology & Therapeutics Co-Editor, xPharm Co-Editor-in-Chief, Current Protocols in Pharmacology Series Editor, Advances in Pharmacology Guest Editor, Biological and Pharmaceutical Bulletin Section Head, Neuropharmacology and Psychopharmacology, Faculty of 1000 Pharmacology Section Editor, Reference Module in Biomedical Sciences

Invited Presentations: October 26th, 2017 – Plenary Lecture “In Vivo Veritas, In Vitro Dolo, Italian Pharmacology Society Meeting, Remini, Italy March 7th, 2018 – NIH Neurotherapeutics Drug Discovery Course Lecture: Alternative Approaches to Drug Discovery, Rockville, Maryland

Teaching Activities: Faculty Advisor Orr Society Mentor for: Lauren Arney 2 – 1 hour group sessions Ojas Patel 2 – 1 hour group sessions Other Student Contact T32 Lecture- Manuscript Preparation 1 – 2 hour group sessions Medical Education CBCL – Alzheimer’s Disease 1 – 2 hour group sessions CBCL – Aplastic Anemia/ Transplant 1 – 2 hour group session CBCL – Renal Artery Stenosis

Enna (continued)

1 – 2 hour group session CBCL – Pulmonary Infection 1 – 2 hour group session CBCL – Cholecystitis/Cholelithiasis 1 – 2 hour group session CBCL – Viral Hepatitis 1 – 2 hour group session CBCL – Diabetes Insipidus 1 – 2 hour group session CBCL – Diabetes and the Pancreas 1 – 2 hour group session Med. School year 2 – Small Group Discussion-CNS Drugs 2 – 2 hour group sessions Med. School year 2 – Small Group Discussion- Toxicology & Chemotherapy 2 – 2 hour group sessions Graduate Advanced Neuroscience 3 – 2 hour sessions KU School of Pharmacy Graduate Student Lecture on Manuscript Preparation 1 – 2 hour session KUMC Psychiatry Residents Lecture- Neurochemistry, Neurotransmitters and Psychiatric Illness 1 – 2 hour session

Research Personnel: Ms. Lynn LeCount, Managing Editor, Biochemical Pharmacology; Pharmacology & Therapeutics; Pharmacology International, and Advances in Pharmacology Ms. Jennifer McNichols, Editorial Coordinator, Biochemical Pharmacology; Pharmacology & Therapeutics, Pharmacology International

Paige C. Geiger, Ph.D., Associate Professor

My research focus is on the cellular mechanisms leading to the development of insulin resistance and type 2 diabetes. My laboratory examines insulin signaling pathways and the regulation of glucose uptake and mitochondrial function in skeletal muscle in response to obesity-inducing high fat diets as well as exercise training and heat treatment. Our research to date has contributed to an understanding of the role of heat shock proteins in metabolic disease with implications for future treatment of diabetes and neurodegenerative diseases.

Meetings Attended: April 2018 – Experimental Biology, San Diego, CA May 2018 – KUMC Exercise is Medicine, Kansas City, KS (co-organizer)

Committee Activities: Departmental Member, Graduate Student Affairs Committee KUMC Chair – Elect, School of Medicine Research Committee Co – Organizer and Faculty Advisor, Exercise is Medicine Symposium Member, Executive Committee WIMS Faculty Advisor, American Medical Women’s Association Member, Cray Diabetes Center Advisory Board Member, Student Union Corporation Board Member, BRTP review committee Student Committee Service: Member, Dissertation Committee, Olivia Eller-Smith, Anatomy, Ph.D. Member, Dissertation Committee, Daniel Elliot, Anatomy, M.D./ Ph.D. Mentor – Joshua Miller Mentor – Vendita Garimella Administrative Facility Co – Director, Metabolic and Obesity Research Phenotyping Facility (MORPh) Community, Regional, and National Activities Exercise Physiology Councilor and Secretary – Treasurer, APS Environmental and Exercise Physiology (EEP) Steering Committee

Editorials and Grant Reviews: Editorial Reviewer, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology Ad Hoc Reviewer, American Journal of Physiology Ad Hoc Reviewer, Journal of Applied Physiology Ad Hoc Reviewer, Journal of Physiology

Teaching Activities: B4 – Respiration and Circulation 3 – 3 hour sessions

Dr. Geiger (continued)

B5 – CBCL Large Group 1 – 1 hour session CBCL 7 – 2 hour sessions PHSL 842 – Human Physiology 11 – 2 hour sessions PHSL 836 – Physiology of Disease 12 – 2 hour sessions

Research Personnel: Alex Von Schulze, Graduate Student, Self-Fellow Fengyan Deng, Ph.D., Research Assistant

Sumedha Gunewardena, Ph.D., Research Assistant Professor

Research Interest: Bioinformatics and computational genomics: modeling protein-DNA interactions, biological sequence analysis, microarray data analysis, biological pathways and network analysis, development of computational tools and databases.

Publications:

Bhattacherjee A, Mu Y, Winter MK, Knapp JR, Eggimann LS, Gunewardena SS, Kobayashi K, Kato S, Krizsan-Agbas D, Smith PG. ``Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome''. Proc Natl Acad Sci U S A. 2017 Jul 31. pii: 201618210. doi: 10.1073/pnas.1618210114. PMID: 28760966 Bhattacherjee A, Winter MK, Eggimann LS, Mu Y, Gunewardena S, Liao Z, Christianson JA, Smith PG. ``Motor, Somatosensory, Viscerosensory and Metabolic Impairments in a Heterozygous Female Rat Model of Rett Syndrome''. Int J Mol Sci. 2017 Dec 29;19(1). pii: E97. doi: 10.3390/ijms19010097. PMID: 29286317 Freitas N, Lukash T, Gunewardena S, Chappell B, Slagle BL, Gudima SO. "Relative abundance of the integrant-derived viral RNAs in infected tissues harvested from chronic HBV carriers". J Virol. 2018 Feb 28. pii: JVI.02221-17. doi: 10.1128/JVI.02221-17. [Epub ahead of print] PMID: 29491161 Kumar D, Yalamanchali S, New J, Parsel S, New N, Holcomb A, Gunewardena S, Tawfik O, Lominska C, Kimler BF, Anant S, Kakarala K, Tsue T, Shnayder Y, Sykes K, Padhye S, Thomas SM. "Development and Characterization of an In Vitro Model for Radiation-Induced Fibrosis". Radiat Res. 2018 Jan 19. doi: 10.1667/RR14926.1. PMID: 29351058

Leslie L. Heckert, Ph.D., Marion M. Osborn Professor for Reproductive Sciences

Through collaboration with Dr. Jill Jacobson at Children’s Mercy Hospital (CMH) I continued research on hormonal and genetic variations in transgender individuals and patients with disorders of sex development. To assist these efforts, I spent a 6-month sabbatical learning genetic variant analysis at the CMH Center for Pediatric Genomic Medicine. This provided new skills in human sequence analysis and the integration of various data sources to help identify relevant variants in mitochondrial disease. I continue to collaborate with Isabelle Thiffalt and Warren Cheung at the Genome Center on evaluation of patients with mitochondrial disorders.

Meetings Attended: April 19 – 22, 2017 – XXIVth North American Testis Workshop. Miami, Florida

Committee Activities: Departmental Member, Department Finance Committee Member, Promotions & Tenure Committee Member, Faculty Recruitment Committee KUMC Member, Institutional Biosafety Committee Member, Transgenic and Gene Targeting Core Oversight Committee Member, IGPBS Curriculum Committee- November Member, IGPBS Advisory Board, November Member, Institutional Biosafety Committee Community, Regional and National Activities Executive Committee, North American Testis Workshop Chair, Program Committee, North American Testis Workshop

Editorial and Grant Reviews: Ad Hoc Reviewer, Molecular and Cellular Endocrinology Ad Hoc reviewer, Biology of Reproduction Ad Hoc reviewer, FASEB Editorial Board Member, Endocrinology

Teaching Activities: CBCL 3 – 2 hour group sessions CBCL 5 – 2 hour group sessions PHSL 842 – Comprehensive Human Physiology 5 – 1 hour sessions Physiology of Disease 1 – 1.5 hour session

Melissa A. Larson, Ph.D. Research Assistant Professor

As the Technical Director of the Transgenic and Gene-Targeting Institutional Facility, my role is largely defined by service. I am responsible for providing services in the generation of gene- modified mice, sperm and embryo cryopreservation, assisted reproductive technologies, and embryonic stem cell propagation and targeting. We provide these services for investigators at KU Med and KU-Lawrence, as well as the entire Kansas City metro area. In addition, I am interested in exploring and implementing new technologies that allow creation of unique mouse research models.

Invited Presentations: October 15 – 18, 2017 – American Association for Laboratory Animal Science National Meeting as a representative for the International Society for Transgenic Technologies, Austin, Texas

Seminars: October 15, 2018 – Genome Editing of the Mouse and Pluripotent Stem Cell Models, Genome Editing Workshop, KUMC, Kansas City, KS

Meetings Attended: October 15 – 18, 2017 – American Association for laboratory Animal Science National Meeting, Austin, Texas October 1 – 4, 2017 – Transgenic Technology Meeting, Salt Lake City, Utah

Committee Activities: KUMC Member, Institutional Animal Care and Use Committee Member, Institutional BioSafety Committee National Representative, American Association for Laboratory Animal Science on behalf of the International Society for Transgenic Technologies

Research personnel: Illya Bronshteyn, M.S., Research Associate Julia Draper, M.S., Research Associate

Phil Lee, Ph.D., Associate Professor

The major focus of my research is to characterize structural, functional, physiological and metabolic changes linked to aging, disease activity and progression using advanced in vivo magnetic resonance techniques. Another important focus of my research is to develop novel in vivo magnetic resonance imaging techniques to offer new possibilities for monitoring the disease status and the impact of treatments through new quantitative, non-invasive biomarkers. My own research and collaboration have yielded 11 publications during this fiscal year.

Invited Presentations: September 8 – 11, 2017 – Workshop oral presentation, Prospective correction for motion-induced frequency drifts in MR Spectroscopy using OVS-localized navigator, ISMRM Workshop on Motion Correction in MRI and MRS, Cape Town, South Africa March 27, 2018 – Invited speaker presentation, Emerging advanced MRS strategies, International Society of Magnetic Resonance in Medicine (ISMRM) Workshop on Advanced Neuro MR: Best Practices for Technical Implementation, Seoul, S. Korea March 31, 2017 – Keynote speaker presentation, Compartment-based spatial localization in quantitative MRI and MRS, International Congress on Magnetic Resonance Imaging (ICMRI) & Annual Scientific Meetings of KSMRM, Seoul, S. Korea

Seminars Presented: December 15, 2017 – Neuroimaging in neurology: Principles and applications, Neurology/Neurosurgery Grand Rounds, KUMC, Kansas City, KS January 22. 2018 – Tissue-type specific measurement of neurochemical and cerebral blood flow using MRI and MRS, Seminars in Physiology, KUMC, Kansas City, KS

Meetings Attended: October 25- 28, 2017 – The 33rd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and 7th Joint ECTRIMS-ACTRIMS meeting, Paris, France

Committee Activities: University Advanced Technology Development Committee of the Hoglund Brain Imaging Center (HBIC) HBIC Executive Committee HBIC Project Review Committee HBIC Staffing Committee Faculty judge for 2017 Resident, Postdoc & Fellow Research Day at KUMC

Dr. Lee (continued)

International Conference Organizing Committee of the International Conference on Brain Energy Metabolism (ICBEM) Service on Student Committees Thesis Committee, M.S. Bioengineering, Sean Ellis Thesis Committee, Ph.D. Otolaryng, Andrea Freemyer

Editorials and Grant Reviews: Ad Hoc Reviewer, Journal of Magnetic Resonance Imaging Ad Hoc Reviewer, Magnetic Resonance Materials in Physics, Biology and Medicine Ad Hoc Reviewer, Neurochemical Research Ad Hoc Reviewer, NMR in Biomedicine Ad Hoc Reviewer, Brain Imaging and Behavior Ad Hoc Reviewer, Neurotoxicity Research Ad Hoc Reviewer, NMR in Biomedicine Conference proceedings of International Society for Magnetic Resonance in Medicine Conference proceedings of American Society for Nutrition Editorial Board member, Neurochemical Research

Teaching Activities: BIOE 899 – Independent Investigation 12 – 1 – 2 hour sessions

Other Activities: Consultant of magnetic resonance imaging program of Center for Brain, Biology and Behavior at University of Nebraska Consultant of the Imaging Center at University of Missouri at Columbia

Research Personnel: Chu-Yu Lee, Postdoc at Hoglund Brain Imaging Center Peter Adany, Senior Research Scientist at Hoglund Brain Imaging Center Sean Ellis, Graduate student of Bioengineering program, KU-L Mariad Thatcher, Research Associate at Hoglund Brain Imaging Center

Steven M. LeVine, Ph.D., Professor

We study two demyelinating diseases of the central nervous system, multiple sclerosis and Krabbe’s disease. We examine pathogenic mechanisms and test experimental interventions in animal models of these diseases. The goal of our studies is to improve treatment options for patients afflicted with these conditions.

Committee Activities: Departmental Member, Graduate Student Advisory Committee Member, Departmental Promotions and Tenure Committee KUMC Member, Safety Committee for the Smith East Building Community Member, Neurodegenerative Subcommittee for the KCALSI Regional Strategic Assessment

Editorials and Grant Reviews: Ad Hoc Reviewer, Immunological Ad Hoc Reviewer, Neural Regeneration Research Ad Hoc Reviewer, Orphanet Journal of Rare Diseases Ad Hoc Reviewer, Neuroscience Letters Grant Reviewer, KUMC Research Institute Internal Clinical Pilot Research Grant Grant Reviewer, Lied Basic Science Grant Programs Grant Reviewer, Austrian Science Fund- Hertha Firnberg

Teaching Activities: PHSL 842 – Human Physiology 4 – 1 hour sessions PHSL 842 – Comprehensive Human Physiology 1 – 1 hour session PHSL 843- Physiology of Disease 2 – 1.5 hour sessions *mentored students for lecture preparation and attended/graded seven additional student presentations CORE 840 – Neuropathy Labs(co-taught) 4 – 2 hour sessions Gastrointestinal- Renal- GI Physiology I, II, III, IV 4 – 1 hour sessions Gastrointestinal- Renal- Constipation(assisted) 1 – 1 hour session

Dr. Levine (continued)

Research Personnel: Rebecca Heidker, Ph.D. – Volunteer Research Assistant, working on paper together Yi Feng, Ph.D. – part-time Postdoctoral Fellow in my lab Mingcai Zhang Ph.D. – part-time Postdoctoral Fellow in my lab Theodore Budden, part-time Research Technician in my lab

Other Activities: Multiple Sclerosis Research Group at KUMC – Member CBL on Constipation for the Gastrointestinal – Renal block – Lead Author

E. Matthew Morris, Ph.D., Research Assistant Professor

Dr. Matt Morris investigates the role of peripheral energy metabolism in the development of obesity, type 2 diabetes, and cardiovascular disease. His work centers on how the function of the primary energy producing cellular bodies, mitochondria, can impact tissue function and ultimately systemic health. The current focus is how liver mitochondrial function can, through neural pathways to the brain, influence high fat diet- induced weight gain via changes in food intake and storage of dietary fat. Meetings Attended: November 30 – October 3, 2017 – Obesity Week, Washington DC

Committees: Service on Student Committees Member, Ph.D. Molecular and Integrative Physiology, Alex Von Schulze

Editorial and Grant Reviews: Ad Hoc Reviewer, Lied Basic Science Grant Program Ad Hoc Reviewer, Vidi Grant, Innovational Research Incentives Scheme of the Domain Science – Netherlands Organization for Scientific Research Ad Hoc Reviewer, Journal of Applied Physiology Ad Hoc Reviewer, Experimental Physiology Ad Hoc Reviewer, Applied Physiology, Nutrition, and Metabolism Ad Hoc Reviewer, Diabetes Care Ad Hoc Reviewer, Physiology & Behavior Ad Hoc Reviewer, Journal of Physiology

Teaching Activities: CBCL – M1 7 –3 hour lectures PHSL 843 – Physiology of Disease 1 – 3 hour lecture PHSL 836 – Advanced Neuroscience 1 – 3 hour lecture

Warren B. Nothnick, Ph.D., H.C.L.D., Professor and Vice-Chair

Research in the Nothnick laboratory focuses on deciphering the role of microRNAs (miRNAs) in the pathophysiology of endometriosis and the potential of targeting these miRNAs and/or their target transcripts as potential therapies for endometriosis treatment. Emphasis is placed upon dissecting these miRNA-mediated pathways utilizing both in vitro and in vivo models. Secondary interests focus on the regulation and function of microRNAs in the decidualization process and endometrial infertility associated with endometriosis and progesterone resistance.

Committee Activities: Departmental Vice-Chairman, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, January 1, 2017 – present Chairman, Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Finance Committee, 2014 – Present. Chairman, Faculty Search Committee, Reproductive Biology Position Student Committee Service: Chair/Mentor, Zahraa Alali, Physiology, Ph.D. Member, Ashley Cloud, Physiology, Ph.D. Member, Sachith Polpitivia Arachchige, Microbiology, Ph.D. Oral Composition Member, Cameron Fox, Physiology, M.D./ Ph.D. Oral Composition Member, JZ Wu, Physiology, Ph.D. KUMC: Director, Center for Reproductive Health Sciences Member, Diverse Faculty Recruitment Committee, School of Medicine Member, Executive Committee of the School of Medicine Faculty Council Chairman, Appointment, Promotion and Tenure Committee, School of Medicine Judge, Poster Presentation Competition, The 14th Annual Gilbert S. Greenwald Symposium on Reproduction Other Activities: Poster Judge, 65th Annual Meeting for the Society for Reproductive Investigation, March 7th – 10th, 2018, Denver, CO

Seminars Presented: September 26th, 2017 – “New insights into the pathophysiology of endometriosis: The role of miR-451a.” University of Colorado School of Medicine, Department of Obstetrics and Gynecology, Denver, CO. November 1st, 2017 – “miR-451a as a central mediator in the pathogenesis of endometriosis.” University of Georgia College of Pharmacy, Pharmaceutical and Biomedical Sciences, Athens, GA.

Meetings Attended: March 6th – 10th – 65th Annual Meeting for the Society for Reproductive Investigation, San Diego, CA.

Dr. Nothnick (continued)

Editorial and Grant Reviews Ad Hoc Reviewer, Biology of Reproduction Ad Hoc Reviewer, Reproductive Sciences Ad Hoc Reviewer, Human Reproduction Ad Hoc Reviewer, Scientific Reports Ad Hoc Reviewer, 2018/10 ZRG1 OBT-R (80) Academic Research Enhancement Award (AREA) study section, Washington, DC, June 13, 2018 (Teleconference) Ad hoc Reviewer, Oregon National Primate Research Center Pilot Research Program, April 2018 Abstract Review Committee, American Society for Reproductive Medicine, Endometriosis special Interest Group 74th Annual Meeting of the American Society for Reproductive Medicine, 2018, Denver, CO Abstract Review Committee, 65th Annual Meeting for the Society for Reproductive Investigation, March 7th – 10th, 2018, San Diego, CA Abstract Review Committee, American Society for Reproductive Medicine, Endometriosis Special Interest Group 73rd Annual Meeting of the American Society for Reproductive Medicine, 2017, San Antonio, TX Study Section Chairperson, 2018/10 ZRG OBT-T (80) The Role of Stem/Progenitor Cells in The Pathogenesis and treatment of Gynecologic Disorders, SEP, Bethesda, MD, June 18, 2018 Overseas External Assessor, National Health and Medical Research Council (NHMRC Australian Government) Grant Review. 2017

Teaching Activities: PHSL 842 – Comprehensive Human Physiology 2 – hour sessions PHSL 843 – Physiology of Disease 1 – 1.5 hour session GSMC 854 – Cell Communication 3 – 2 hour lectures CBCL Moderator PGY1 7 – 14 hour sessions

Research Personnel: Amanda Graham, Research Associate Zahraa Alili, Pre – Doctoral Student Ayushi Vashisht, Pre – Doctoral Student

Peter G. Smith, Ph.D., John H. Wineinger, M.D. Professor, Senior Associate Dean for Research

My research interests include: i) Mechanisms of peripheral nervous system plasticity leading to sensory nerve sprouting in increased mechanical sensitivity; ii) Role of the peripheral sensory nervous system in abnormal sensitivity in Rett syndrome and related Autism Spectrum Disorders; iii) Repair of the damaged nervous system using stem cell- derived neuronal precursors; iv) Creation and characterization of cellular and organismal models of genetic neurodevelopmental disorders.

Meetings Attended: November 19 – 21, 2017: Intellectual and Developmental Disability Research Centers Directors’ meeting. St. Louis, MO.

Committee Activities: University Committees KUMC Senior Associate Dean for Research Chair, Research Advisory Council Chair, Research Institute Research Committee Director, Frontiers Pilots Collaborative Research Projects programs, CTSA Chair, KUMC Genomics Core Advisory Committee Member, Mass Spectroscopy Advisory Board Affiliate Member, KU Cancer Center Member, Alzheimer’s Disease Center Internal Advisory Board, and Executive Committee Editorial and Grant Reviews: Ad Hoc Reviewer, Nutritional Neuroscience Ad Hoc Reviewer, Journal of Investigative Dermatology Associate editor, Autonomic Neuroscience: Basic and Clinical Chair, SPACE/ETTN-B(56) review panel for Stimulating Peripheral Activity to Relieve Conditions, Bethesda MD, July 19th, 2017 Chair, NCCIH Center of Excellence for Research on Complementary and Integrative Health (P01) WebEx-based Review Meeting, March 23rd, 2018

Teaching Activities: Advanced Neuroscience 2 – 2 hour sessions CBCL, M1 7 – 2 hour sessions M1: R&C – Autonomic Neuroscience; cardiovascular control 2 – 1 hour sessions

Dr. Smith (continued)

Research Personnel: Anuradha Chakrabarty, Ph.D. Senior Scientist Sarah Tague, Ph.D. Senior Scientist Aritra Bhattacherjee Ph.D. Post- doctoral fellow Zhaohui Liao, M.D., Research Associate Dora Krizsan- Agbas Ph.D., Senior Scientist

John A. Stanford, Ph.D., Associate Professor

My research is focused on preclinical models of normal aging and age-related diseases and conditions that affect motor function, such as Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS) and neonatal hyperbilirubinemia (kernicterus). We are currently examining the effects of isometric strength training on neuromuscular denervation in aged rats, in rats that differ in inherent aerobic capacity, and in the SOD1-G93A rat model of ALS. Our most recent studies involve determining the survival and phenotype of stem cells transplanted in the brains of jaundiced vs non-jaundiced Gunn rats.

Meetings Attended: November 1 – 15, 2017 – 47th Annual Meeting of the Society for Neuroscience, Washington, D.C. April 26 – 29, 2017 – 25th Annual Meeting of the American Society for Neural Therapy and Repair, Clearwater Beach, FL

Invited Presentations: September 11th, 2017 – My Rat Can Lick Your Rat! Developing Translatable Exercise Interventions for Neuromuscular Function. Keynote presentation for the 9th Annual Fall Retreat of the Neurological and Rehabilitation Sciences Training Program. University of Kansas Medical Center, Kansas City, KS April 26th, 2018 – Effects of Traumatic Brain Injury on Measures of Limb and Tongue Function in Rats. 25th Annual Meeting of the American Society for Neural Therapy and Repair/15th Annual Meeting of the International Society for Neural Therapy and Repair, Clearwater Beach, FL

Committee Activities: Departmental Member, Physiology Finance Committee Member, Physiology Graduate Student Affairs Committee Student Committee Service Member, Lauren McLean, KCU, College of Biosciences II-year Research track program Member, Mercy Adewale, KCU, College of Biosciences II-year Research track program Member, Page Haley, Physiology, Ph.D. Member, Consuelo Perez Sanchez, Physiology, Ph.D. KUMC Member, Rodent Behavior Advisory Committee Member, KUMC Neuroscience Graduate Program Advisory Committee Member, KIDDRC Core B Advisory Committee Member, Society for Neuroscience Kansas City Chapter Executive Committee Co-President, Society for Neuroscience Kansas City Chapter Member, KUMC Faculty Council

Dr. Stanford (continued)

Member, KUMC IGPBS Admissions Committee (Neuroscience representative) Program Director, KUMC Biomedical Research Training Program Campus Coordinator, K-INBRE Program Director and KUMC Community National: Member, Teachers and Students for Community Oriented Research Education Advisory Board Chair and awards committee, National IDeA Symposium for Biomedical Research Excellence Member, Steering Committee, National IDeA Symposium for Biomedical Research Excellence Member, College & Careers Advisory Board, Member, Diploma+ Program, Kansas City Public Schools Member, Councilor and Scientific Program Committee Member, American Society for Neural Therapy and Repair

Editorial and Grant Reviews: Member, NIH CSR Motor Function Speech and Rehabilitation (MFSR) Study Section Ad Hoc Reviewer, Movement Disorders Ad Hoc Reviewer, Journal of Applied Physiology Ad Hoc Reviewer, Brain Research Bulletin Ad Hoc Reviewer, Neurobiology of Disease Ad Hoc Reviewer, Journal of Cerebral Blood Flow and Metabolism Ad Hoc Reviewer, Behavioral Brain Research Ad Hoc Reviewer, Neurochemistry International Ad Hoc Reviewer, Redox Biology Ad Hoc Reviewer, Neurobiology of Learning and Memory

Teaching Activities: PHSL 846 – Advanced Neuroscience Course Director 9 – 2 hour sessions PHSL 843 – Physiology of Disease 2 – 1.5 hour sessions Brain and Behavior 4 – 4 hour group sessions

Dr. Stanford (continued)

Research personnel: Kimberly Stanford, M.A. – Research Associate: Resistance training and neuromuscular junctions in aging and ALS Jane Yang, Ph.D. – Postdoc: Preclinical Studies of Kernicterus Sean Riordan, Ph.D. – Postdoc: Preclinical Studies of Kernicteru Emma Renwick – High School Student: Neural Effects of Resistance Exercise in Aged Rats Emily Fey – High School Student: Neural Effects of Resistance Exercise in Aged Rats

Joseph S. Tash, Ph.D. Professor

My research interests, funded by NIH, focus on the discovery and development of reversible non-hormonal male contraceptives. In addition, my NASA funded research is focused on elucidating the impact of long term space flight on reproductive health in males and females. In January of 2017, I decided to enter the Phased Retirement Program for a period of one year. I retired on January 14, 2018 and became Emeritus Professor on January 15, 2018.

Meetings Attended: NICHD CRB U54/U01 Steering Committee meeting, Bethesda, MD, October 15 - 17, 2017 NASA Equipment Verification Test at Bioserve in Boulder, CO, October 17 – 22, 2017 32nd Annual Meeting of the American Society for Gravitational and Space Research. Seattle, WA; October 25 – 29, 2017

Committee Activities: Departmental Member, Department Promotion and Tenure Committee.

Research personnel: Lesya Holets, Ph.D., Senior Scientist, Cell-cycle regulatory kinases as targets for male contraceptive drug development, H2-Gamendazole analogues as reversible non-hormonal male contraceptive agents Eric Yarns, Research Assistant, Space flight-altered motility activation and fertility-dependent responses in sperm from sea urchin and rodents, Female reproductive health: Space flight induced ovarian & estrogen signaling dysfunction, adaptation, and recovery

John P. Thyfault, Ph.D., FACSM, Associate Professor

1. Links between fatty liver, hepatic mitochondrial dysfunction, and low aerobic fitness and the role that hepatic PGC-1a may be playing in this process 2. Role of hepatic mitochondrial function to impact systemic metabolism and regulation of energy intake and physical activity 3. Role of physical activity and inactivity to modulate insulin action and glycemic control 4. Impact of statins to negatively impact the ability of exercise training to improve skeletal muscle mitochondrial content and aerobic fitness

Committee Activities: Departmental Search Committee, Reproduction Biologist Faculty Position Student Committee Service Member, Ian Huck, Pharmacology, Toxicology, Therapeutics, IGBPS Member, Michael Cooper, Anatomy, IGBPS Member, Ashley Ward, Physiology, IGBPS Member, Shaima Alothman, Physical Therapy, Ph.D. Member, Yuan Li, Pharmacology, Toxicology, Therapeutics, Ph.D. Member, Scott Koppel, Neuroscience, Ph.D. Member, Pao Yen Wu, Anatomy & Cell Biology Member, Olivia Eller-Smith, Neuroscience, Ph.D. Member, Shaolei Xiong, Stowers, Ph.D. KUMC Scientific Director – Children’s Mercy Healthy Lifestyle and Nutrition Center – (KUMC/CMH joint funded center) Community Committee, Kansas City VA IACUC Planning Committee, Obesity Society meeting Co-Director, Integrative Physiology Track 2017 – 2018

Invited Presentations: September 27, 2017 – Fitness impacts susceptibility for metabolic disease. The Charles River World Congress Meeting. Boston, MA November 2, 2017 – Exercise plus liver= health. The Obesity Society- Obesity Week Annual Meeting. Washington D.C.

Meetings Attended: November 1 – 4 – The Obesity Society Meeting, Washington DC

Editorial and Grant Reviews: Member, NIH Integrative Physiology of Obesity and Diabetes (IPOD) study section Ad Hoc Reviewer, Diabetes Ad Hoc Reviewer, AJP Endocrinology and Metabolism Ad Hoc Reviewer, Diabetologia

Dr. Thyfault (continued)

Ad Hoc Reviewer, Journal of Clinical Endocrinology & Metabolism Ad Hoc Reviewer, JCI Ad Hoc Reviewer, Experimental Physiology Ad Hoc Reviewer, Journal of Applied Physiology Ad Hoc Reviewer, Medicine in Sciences and Sports and Exercise Ad Hoc Reviewer, Physiology Behavior Associate Editor, Experimental Physiology Associate Editor, Physiological Genomics Associate Editor, Journal of Applied Physiology

Seminars Presented: November 15, 2017 – Hepatic fitness and susceptibility for metabolic disease, University of Buffalo, Department of Nutrition and Exercises, Buffalo, NY November 17, 2017 – Movement = Medicine: The critical role of physical activity for treatment of type 2 diabetes. Second Annual Kansas City Regional Diabetes Summit. February 7, 2018 – Hepatic fitness and susceptibility for obesity and metabolic dysfunction. UMKC School of Dentistry, Kansas City, MO April 10, 2018 – Hepatic fitness and susceptibility for metabolic disease. University of Pennsylvania Diabetes and Obesity Research Center, Philadelphia, PA

Courses Taught: Medical School Lecture- Exercise and Diabetes 1 – 1 hour session CBCL 2 – 3 hour sessions CBCL 2 – 3 hour sessions IGPBS Cell Biology Course – Integrative Metabolism 3 – 3 hour sessions PHSL 843 Physiology of Disease – Diabetes 1 – 3 hour session

Research Personnel: Julie Allen – Lab Manager Dr. E. Matthew Morris – Research Assistant Professor: Role of hepatic mitochondrial function to impact weight gain Dr. Colin McCoin – Post-Doctoral Fellow: Statins and mitochondrial function Adrianna Maurer, IGPBS Ph.D. Student: Bile acids and fitness Alex Von Schulze, IGPBS Ph.D. Student: Hepatic mitochondrial function, eat shock proteins, and mitophagy Kelly Fuller, Graduate Student: Statins and mitochondrial function

Ning Wang, Ph.D., Assistant Professor

Spermatogenesis is a classic stem cell dependent process essential for male reproduction. Undifferentiated spermatogonia with spermatogonial stem cells (SSCs or male germline stem cells, GSCs) at the foundation of the differentiation hierarchy undergo both self-renewal and differentiation to support lifelong production of sperm. We employ molecular, cellular, genetic, and transplantation approaches to investigate the mechanism regulating SSCs maintenance and meiotic differentiation. In addition to the basic science importance, our studies will aid the development of SSC transplantation therapy to improve and rescue fertility in clinical settings.

Joined the department on May 1, 2018.

Research Personnel: Bailey Bye, Research Assistant Xiaoyu Zhang, Ph.D., Postdoctoral Fellow

Michael W. Wolfe, Ph.D., Associate Professor

Research in my laboratory has focused on estrogen signaling and its control of reproduction and metabolism. Use rat models in which estrogen receptor alpha or beta has been mutated. These receptors have differential and at times opposing functions. We have found that loss of estrogen signaling leads to female infertility, hyperplasia of the male prostate and alterations in metabolism including hepatic function.

Meetings Attended: August 29th, 2017 – Mechanisms of Liver Injury and Diseases COBRE Pilot Grants Symposium, KUMC October 19 – 20, 2017 – 14th Annual Gilbert S. Greenwald Symposium on Reproduction, Kansas City, KS April 3 – 5, 2018 – “Plagiarism: The identification, processing, prevention and cultural context on plagiarism” Indianapolis, IN

Committee Activities: Departmental Director, Graduate Student Advisory Committee Student Committee Service Member, Ashley Ward, Physiology, Ph.D. Member, Zelha Nil, Physiology, Ph.D. Member; Chair- Comprehensive Exam, Jianzheng Wu, Physiology, Ph.D. Member, Bhaswati Bhattacharya, Pathology, Ph.D. Member, Eric Young, Cancer Biology, M.D./Ph.D. Member, Li Chen, Physiology, Ph.D. Member, Elizabeth Thoenen, Physiology, Ph.D. Chair- Comprehensive Exam, Cameron Fox, Physiology, Ph.D. KUMC Officer, KUMC Research Integrity Member, KUMC Graduate Council Member, IGPBS Advisory Board Member, KUMC Responsible Conduct of Research program advisory committee Member, Frontiers Training Center Advisory Committee (FTCAC) Part of the Frontiers Clinical and Translational Science Award

Invited Presentations: August 19th, 2017 – “Estrogen regulation of metabolism and liver function.” Gave presentation at the Mechanisms of Liver Injury and Diseases COBRE Pilot Grants Symposium

Editorial and Grant Reviews: Reviewer, Journal of Assisted Reproduction and Genetics

Dr. Wolfe (continued)

Teaching Activities: CORE 805 – Molecular & Cellular Medicine 1 – 1 hour session Reproduction, Development & Sexuality (course director) CBCL 7 – 2 hour group sessions GSMC 856 – Introduction to Research Ethics (course director) 12 – 1 hour sessions PHSL 842 – Comprehensive Human Physiology (co-director) 10 – 1 hour sessions PHSL 832 – Physiology of Disease 1 – 1.5 hour session PHSL – 843 (Mentored 2 students presenting lectures) 4 – 1 hour group sessions

Research personnel: Subhra Gosh, Research Technician Khyati Dalal, Research Assistant Dr. Vincentaben Khristi, Research Assistant Dr. Praveen Chakravarthi, Post-doctoral fellow Andres Calva Lopez- 3rd year Medical Student from University of Navarra

John G. Wood, Ph.D., Professor, Director of Educational Programs

Currently our major goal is to examine mechanisms responsible for the microvascular inflammatory response following cutaneous thermal injury. These experiments are in collaboration with Drs. James Howard and Rob Winfield in the Dept. of Surgery. Intravital microscopy is used to quantitate microvascular alterations in mesenteric post- capillary venules.

Committee Activities: Student Committee Service Member, Thesis Committee, Blake Ebner, Physiology, M.D./Ph.D. Member, Thesis Committee, Lugi Duan, Pharmacology, Ph.D. Member, Thesis Committee, Afreen Sayed, Surgery, Ph.D. KUMC Member, Chancellor’s Distinguished Teaching Award Selection Committee Member, Delp Academic Society Member, Institutional Animal Care and Use Committee Member, Phase I Committee Member, Student Liaison Departmental Member, Surgery Research Committee Member, Surgery Residency Applicant Interviews Member, Surgery Resident Education Committee

Invited Presentations: October 2017 – Cutaneous burn – Induced microvascular inflammation in rat mesenteric venules carbon monoxide is attenuated by upregulation of heme oxygenase, American College of Surgery, San Diego, CA (Jonathan Warren, M.D. Surgery Resident)

Teaching Activities: Medical Education Step Preparation Board Review – CV Review 1 – 1.5 hours session Pre- Matriculation – CV 11 – 1 hour sessions Pre-Matriculation Respiration and Circulation – CV 13 – 1 hour sessions Cardiopulmonary simulation sessions 5 – 1 hour sessions Integration and Consolidation – CV 3 – 1 hour sessions CBCL Facilitator 12 – 2 hour sessions

Dr. Wood (continued)

Graduate Physiology Graduate Course 7 – 1 – 2 hour sessions

Research Personnel: Naomi Holloway, Research Assistant Jonathan Warren, M.D., Resident in Dept. of Surgery