Minipigs As Laboratory Animals - Review
RESEARCH IN PIG BREEDING, 9, 2015 (2) MINIPIGS AS LABORATORY ANIMALS - REVIEW Rozkot M., Václavková E., B ělková J. Institite of Anbimal Science Prague, Czech Republic Abstract Minipigs are one of the most important laboratory animals because of their similarity to human. The minipigs had several advantages as a laboratory animal. They are small thus much easier for handling. Also, requirements of food, space and even pharmacologic products or anesthetic are significantly reduced. Miniature pigs have a convenient body size for surgical procedures and given their anatomical similarities to humans particularly in terms of skin, skeleton, teeth, gastrointestinal tract, pancreas, liver, kidney, lung, and immune status they are often used as models for humans. In cardiac research, they are often used for studies on cholesterol. They are widely used in pharmacology research and diabetes research. In this review, we summarized several information and guidelines related with minipigs, especially about their history, breeding and using as model laboratory animal. Key Words : minipig, laboratory animal, breeding Minipigs are regarded as one of the most important that has application to humans. Miniature pigs are laboratory animal in that anatomical and physiological purpose bred for research; they are smaller than those properties are similar to human and their reproduction bred for production, with a much slower growth efficiency is relatively higher compared to other large curve, but physiologically in all other ways they are animal species. Particularly, several diseases that similar to agricultural pigs. The exponential growth cannot be mimicked in rodent models are successfully curve begins at 3 months; for research lasting longer occurred or induced in pig models therefore it has than 3 weeks, miniature swine are preferable both for been interested in a valuable model for human handling ease and welfare considerations .
[Show full text]