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Subject Index Subject Index AAE-581 compound, cefotaxime, 444, 454–455 osteoporosis/osteopenia therapy, cefpodoxime proxetil, 444, 454 251 cefprozil, 444, 453–454 Abdominal obesity ceftriaxone, 444, 455–456 metabolic syndrome, 122–123 cefuroxime axetil, 444, 453 pathophysiology of, 186–188 fluoroquinolones, 445, 447, Abscesses, pathophysiology, 564–565 463–467 Acarbose, type 2 diabetes therapy, 341, gatifloxacin, 445, 447, 344, 349, 366–367 466–467 ACE inhibitors, diabetic retinopathy levofloxacin, 445, 447, therapy, 14–16 464–465 captopril, 14, 16 moxifloxacin, 445, 447, lisinopril, 14–16 465–466 Acinetobacter sp., skin and soft tissue glycopeptides, 445, 469–471 infection ketolides, 445, 462–463 amikacin therapy, 597–598 macrolides, 444, 458–461 ertapenem therapy, 575, 587–588 azithromycin, 444, 461 Acute coronary syndrome, reverse lipid clarithromycin, 444, 460 transport pathway activators, 82, erythromycin, 444, 459–460 89–90 penicillins, 444, 447–452 Acute exacerbations of chronic amoxicillin, 444, 449–450 bronchitis (AECB) amoxicillin/clavulanate, 444, antibiotic resistance, 441–443 450–451 clinical presentation, 440 piperacillin/tazobactam, 444, comorbidities, 441 451–452 complications, 440–441 tetracyclines, 445, 467–469 current therapies, 443–471 emerging therapies, 471–482 antibiotic selection and cephalosporins, 477–478 resistance, 444, 446–447 dihydrofolate reductase inhibitors, carbapenems, 444, 457–458 447, 481–482 cephalosporins, 444, 452–457 fluoroquinolones, 472–477 cefdinir, 444, 456–457 garenoxacin, 474–475 Wiley Handbook of Current and Emerging Drug Therapies, Volumes 1–4 Copyright 2007 Decision Resources, Inc. Published by John Wiley & Sons, Inc. 811 812 Subject Index Acute exacerbations of chronic Advanced Inhaled Research (AIR) bronchitis (AECB) (continued) Insulin gemifloxacin, 472–475 type 1 diabetes, 298, 305 sitafloxacin, 476–477 type 2 diabetes, 397–398 ketolides, 478–479 AERx Insulin Diabetes Management peptidyl deformylase inhibitors, System (NN-1998) 480–481 type 1 diabetes, 298, 303–305 streptogramins, 479–480 type 2 diabetes, 396–397 epidemiology, 429–430 African Americans, hepatitis C in etiology, 430–436 hepatocellular carcinoma risk and, bacterial involvement, 432–433 628, 639 chronic underlying airway therapeutic efficacy in, 657–658 disease, 430–432 Age pathogens, 433–436 community-acquired pneumonia risk pathophysiology, 436–442 and, 506–508 bacterial re-infections, 438 methicillin-resistant Staphylococcus host defenses, 438–440 aureus risk and, 717 risk factors, 441 Age-related macular degeneration Acute myocardial infarction (AMI), (AMD), fluocinolone acetonide simvastatin therapy, 57 therapy, 22 Acyl-CoA cholesterol acyltransferase Age-related osteoporosis (ACAT) inhibitors, dyslipidemia etiology, 225 therapy, 82, 90–91 risk factors, 227–228 eflucimibe, 82, 91 Alanine aminotransferase (ALT) Adherence mechanisms, monitoring, type 2 diabetes methicillin-resistance therapy, peroxisome Staphylococcus aureus virulence proliferator-activated and, 715–716 receptor-gamma agonists, 340 Adipocytes Albuferon-alpha, hepatitis C therapy, metabolic syndrome and secretion 667, 672–674 of, 131–133 obesity etiology and, 178–179 Alcohol consumption, secondary dyslipidemia, 45, 48 type 2 diabetes etiology, 325–327 Adipose tissue, type 2 diabetes Alendronate, osteoporosis/osteopenia etiology, 325 therapy, 232–233, 237–240 Adrenergic system, obesity etiology parathyroid hormone analogues and, and, 179 236 Adult-onset diabetes. See Type 2 Preos/Preotact with, 255 diabetes Alpha-glucosidase inhibitors (AGIs) Advanced glycation end products metabolic syndrome therapy, 138, (AGEs) 144 diabetic retinopathy type 2 diabetes therapy, 341, 344, protein kinase C-beta and, 9–10 349, 366–368 vascular endothelial growth factor acarbose, 341, 344, 349, 366–367 and, 10–11 miglitol, 341, 344, 349, 367–368 type 1 diabetes, hyperglycemia and, voglibose, 341, 344, 349, 368 283–284 Amantadine, hepatitis C therapy, 668, type 2 diabetes, 336 689–691 Subject Index 813 AMG-162 compound, Anaerobic bacteria, skin and soft tissue osteoporosis/osteopenia therapy, infection etiology, ceftriaxone 251–253 therapy, 592–593 Amikacin, skin and soft tissue infection Angiotensin-converting enzyme (ACE) therapy, 575, 597–598 inhibitors, metabolic syndrome Aminoglycosides therapy, 139, 158–159 community-acquired pneumonia Angiotensin II receptor antagonists therapy, 511, 514, 538 diabetic retinopathy therapy, 20, skin and soft tissue infection 25–26 therapy, 575, 579, 596–598 candesartan, 20, 25–26 amikacin, 575, 597–598 metabolic syndrome therapy, 139, gentamicin, 575, 596–597 159–162 Amlidopine Anorexia nervosa, secondary dyslipidemia, 48 dyslipidemia therapy, atorvastatin Antibiotics combined with, 52, 69–70 acute exacerbations of chronic metabolic syndrome therapy, bronchitis, resistance, 441–443, atorvastatin with, 138, 155–156 446–447 Amoxicillin community-acquired pneumonia acute exacerbations of chronic emerging therapies, 542–544 bronchitis therapy, 444, resistance to, 508–516 449–450 selection criteria, 509–512 community-acquired pneumonia methicillin-resistant Staphylococcus therapy, 510, 513, 517–518 aureus risk and use of, 717 Amoxicillin/clavulanate limits on, 720–721 acute exacerbations of chronic therapeutic selection criteria, bronchitis therapy, 444, 723–724 450–451 resistance to community-acquired pneumonia community-acquired pneumonia therapy, 510, 513, 518–519 and, 508–509 skin and soft tissue infection methicillin-resistant therapy, 575, 582–583 Staphylococcus aureus risk Amoxicillin/sulbactam, skin and soft and use of, 717 tissue infection therapy, 575, limits on, 720–721 581–582 skin and soft tissue infection, Amylin, obesity etiology and, 183–184 576–579 Amylin analogues skin and soft tissue infection type 1 diabetes therapy, 299, emerging narrow-spectrum 312–314 agents, 606–608 pramlintide, 299, 313–314 resistance to, 577–579 type 2 diabetes therapy, 342, 345, selection criteria, 576–577 376–377 Antibody therapies, hepatitis C virus, pramlintide, 342, 345, 376–377 668, 691–692 Amyotrophic lateral sclerosis (ALS), civacir, 668, 692 recombinant ciliary neurotrophic HuMax-HepC, 668, 692 factor, 207 XTL-6865, 668, 692 ANA-975 agent, hepatitis C therapy, Anti-CD3 antibody, type 1 diabetes 667, 677 therapy, 298, 309 814 Subject Index Antidiabetic agents, metabolic pancreatic lipase inhibitors, 138, syndrome therapy, 137–145 146–148, 164, 168–169, alpha-glucosidase inhibitors, 138, 190–194 144 peripherally acting agents, 202–204 biguanides, 137–139, 141 ATL-962, 202–204 fixed-dose combinations, 138, GI-181771, 202, 204 144–145 HMR-1426, 202, 204 peroxisome proliferator-activated serotonin and norephinephrine receptor agonists, 138, 141–144 reuptake inhibitors, 138, Antidyslipidemic agents, metabolic 148–149, 192, 194–197 syndrome therapy, 138, 149–150 sibutramine, 192, 195–197 Antigen-presenting cells (APCs), type thermogenic agents, 204, 211–212 1 diabetes, insulitis and, 279–281 L-796568, 204, 212 Antihypertensives Antiresorptive agents, dyslipidemia therapy, statins osteoporosis/osteopenia therapy, combined with, 70 231–250 emerging therapies, 163–164 bisphosphonates, 237–242 metabolic syndrome therapy, 139, parathyroid hormone analogues and, 158 236 ACE inhibitors, 139, 158–159 Antiviral agents, hepatitis C therapy, angiotensin II receptor 668, 689–691 antagonists, 139, 159–162 amantadine, 668, 689–691 Antimicrobial resistance celgosivir, 668, 691 community-acquired pneumonia and, AOC-9604 compound, obesity therapy, 508–509 205 methicillin-resistant Staphylococcus Apolipoprotein subfractions, aureus risk and use of, 717 dyslipidemia therapy, 82 limits on, 720–721 Appetite suppressants. See Antiobesity skin and soft tissue infection, agents 576–579 Arrhythmias, sibutramine therapy and Antimicrobial switching, risk of, 197 methicillin-resistant Staphylococcus aureus prevention, 720–723 Arzoxifene, osteoporosis/osteopenia therapy, 259 Antiobesity agents cannabinoid receptor antagonists, Astrocytes, diabetic retinopathy, 4–5 164–168 Atherosclerosis centrally acting agents, 202, atorvastatin/torcetrapib combined 204–211 statin therapy, 85–86 bupropion, 204, 210–211 CETi-1 vaccine and, 88 recombinant human ciliary disease markers, 47 neurotrophic factor, 202, implitapide therapy, 95 206–208 reverse lipid transport pathway rimonabant, 204, 208–210 activators, 82, 89–90 metabolic syndrome therapy, 138, ATL-962 agent 145–146 metabolic syndrome therapy, 164, noradrenergic anorectic agents, 192, 169 197–199 obesity therapy, 202–204 mazindol, 199 Atorvastatin phentermine, 198–199 dyslipidemia therapy, 52, 54–56 Subject Index 815 amlodipine combined with, 52, skin and soft tissue infection 69–70 therapy, 607, 614–615 ezetimibe combined with, 75–76 Bariatric surgery, obesity therapy simvastatin/ezetimibe combined using, 200–201 therapy vs., 68 Basic fibroblast growth factor (bFGF), torcetrapib combined with, 82, diabetic retinopathy, 8 84–86 Bazedoxifene, osteoporosis/osteopenia metabolic syndrome therapy, 138, therapy, 252, 260–261 153–154 BB-81384 agent, acute exacerbations amlidopine with, 138, 155–156 of chronic bronchitis therapy, 481 torcetrapib with, 164, 173–174 Behavior Autoimmune response, type 1 diabetes, obesity etiology and, 184–186 pancreatic beta cell destruction, sibutramine therapy and, 196–197 279–281 obesity therapy and modification of, Autonomic neuropathy 199–201 type 1 diabetes, 284 Benzylpenicillin (Penicillin G), skin type 2 diabetes, 336–337 and soft tissue infection therapy, AVE-0010 agent, type 2 diabetes 575, 580–581 therapy,
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