Zinc Ascorbate Glycinate

Bioavailable 100% Pure & Compressible & High Zinc Chelate Fully Reacted Highly Soluble Content

Chemical Formula ZnC8H11NO8 · X H2O

Molecular Weight 314.6

Description Free-flowing Powder Compressibility & Solubility Health Benefits of Glycine Zinc ascorbate glycinate co-salt delivers zinc, ascorbic Glycine is believed to be beneficial in reducing oxidative acid (vitamin C) and glycine in a single water-soluble stress through production of glutathione in the body1-3. dosage unit without the need for blending or combining Glycine is used by the body to produce creatine, a multiple components. substance shown to increase muscle size, strength, and power4-6. Glycine and has also been studied for its beneficial effects on bone health, brain function and neurological Zinc Content (anhydrous) 20% minimum conditions like Parkinson’s and Alzheimer’s disease3-6. Glycine is a major constituent of collagen, which is known Vitamin C Content (anhydrous) 44% minimum to promote skin health, relief of joint pain and prevention Glycine Content (anhydrous) 20% minimum of bone loss7-14. Other studies also show that glycine may also benefit sleep quality and mental cognition15-18. Solubility 10% at 25°C pH Neutral (6-8)

Taste & Odor No “bad” glycine taste

Bioavailability Our zinc ascorbate glycinate co-salt compound incorporates an equal molar ratio of ascorbic acid and glycine, completely neutralized with zinc in a metal to ligand ratio of 1:1:1. Zinc ascorbate glycinate is 100% pure chelate, which can be readily verified for identity, purity, and potency. Chelated minerals are often a preferred choice by nutritionists because their complex structures better survive passage through the stomach to the small intestine where absorption into the bloodstream occurs.

High Purity It is common to find higher levels of lead in zinc products because they are found in the same ore deposits. This can make sourcing zinc salts with low lead levels Zinc Ascorbate Applications extremely difficult. Jost has a process to manufacture Dietary supplements low lead Zinc Ascorbate Glycinate. Jost products meet Clinical applications the heavy metal requirements of ICH Q3, California Prop 65, USP <232> Elemental Impurities, and The European Regulation No. 629/2008 (amending 1881/2006).

Arsenic (as As) 3 ppm maximum Jost Chemical is a leading manufacturer of

Lead (as Pb) 2 ppm maximum high purity mineral salts. We manufacture and test everything we sell.

Zinc Ascorbate Glycinate Fully Reacted Committed to Quality for more than 35 years Jost mineral salts are fully reacted. The process for > Manufacturing in the United States and Europe manufacturing fully reacted pure salts involves the reaction of an acid and a base in an aqueous solution and the > In-house tested precipitation of a salt compound. Dissolving the reactants > USP/EP/FCC mineral salts provides the opportunity for a complete reaction to occur. > cGMPcompliant, FDA-registered facilities The use of mineral salts containing unreacted com- pounds can lead to: > Consistent from lot-to-lot and meet all customer requirements Formulation stability problems > Provide particle size options Inaccurate ingredient declarations on the finished product label > Custom product development and technical support Post blending issues > Traceability from raw material to end product Tablet issues Human consumption / Digestion / Absorption issues Packaging issues

Immunity & Nutrition Product Formats

Ready-to-Drink Clear Beverages / Liquid Applications For ready-to-drink clear beverages, we suggest water soluble zinc salts. Zinc Ascorbate Glycinate is soluble and also has good zinc content.

Ready-to-Drink Shakes and Liquids

with Insoluble Components Typically insoluble zinc salts are recommended for ready-to-drink shakes, but water soluble salts, such as Zinc Ascorbate Glycinate, can also be used.

Powder Pre-mixes Water soluble zinc salts are ideal for powder pre-mixes Capsules for clear beverages. Insoluble zinc salts can also be used Capsules need product with good flowability, high bulk for shakes. Zinc Ascorbate Glycinate is soluble and also density and higher mineral content. High mineral content has good zinc content. and high density is ideal for smaller capsules.

Tablets Gummies & Lozenges Tablets need product with good flowability, high bulk Water soluble Zinc salts that are heat/shear stable are density, higher mineral content and decent compressibility recommended for gummies and lozenges. Zinc Ascorbate profiles. Zinc Ascorbate Glycinate is recommended. Glycinate is an excellent choice.

Zinc Ascorbate Glycinate Health Benefits of Zinc More Jost Zinc Product Offerings The trace mineral zinc is essential for body growth, Zinc Acetate maturation and development, as well as tissue repair and Zinc Ascorbate resistance to disease. Zinc is an important mineral for children and the elderly. Zinc is involved in numerous Zinc Bisglycinate aspects of cellular metabolism. It is required for the Zinc Sulfate Monohydrate catalytic activity of approximately 100 enzymes, and it Zinc Sulfate Heptahydrate plays a role in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. Zinc also sup- Zinc Gluconate Hydrate ports normal growth and development during pregnancy, Zinc Lactate Dihydrate childhood, and adolescence and is required for proper Zinc Citrate Dihydrate sense of taste and smell. Zinc Phosphate Zinc supplementation has been used to help with: Zinc Oxide Immune function Wound healing Groups at Risk of Zinc Inadequacy Tissue growth People with gastrointestinal and other diseases Diarrhea Vegetarians The common cold Pregnant and lactating women Fertility and reproduction Older infants who are exclusively breastfed Age-related macular degeneration People with sickle cell disease Alcoholics Zinc RDA Zinc is an essential mineral that must be absorbed in small amounts to keep humans healthy. A daily intake of zinc is required to maintain a steady state because the body has no specialized zinc storage system.

Age Male Female Pregnancy Lactation

0–6 months 2 mg* 2 mg*

7–12 months 3 mg 3 mg

1–3 years 3 mg 3 mg

4–8 years 5 mg 5 mg

9–13 years 8 mg 8 mg

14–18 years 11 mg 9 mg 12 mg 13 mg

19+ years 11 mg 8 mg 11 mg 12 mg * Adequate Intake (AI)

(Internet source: National Institutes of Health; Office of Dietary Supplements and references there-in, EU Register of nutrition and health claims made on foods)

Zinc Ascorbate Glycinate Health Benefits of Vitamin C Vitamin C, also known as L-ascorbic acid, is a water- soluble vitamin required for the biosynthesis of collagen, L-carnitine, and certain neurotransmitters. Collagen is an essential component of connective tissue, which plays a vital role in wound healing. Vitamin C is also an important physiological antioxidant and has been shown to regener- ate other antioxidants within the body, including alpha-to- copherol (vitamin E). Vitamin C is also involved in protein metabolism, plays an important role in immune function and improves the absorption of nonheme iron, the form of iron present in plant-based foods. Insufficient vitamin C intake causes scurvy, which is characterized by fatigue or lassitude, widespread connective tissue weakness, and capillary fragility.

Vitamin C supplementation has been used to help with:

Cancer prevention Cancer treatment Cardiovascular disease Age-related macular degeneration (AMD) and cataracts The common cold

Vitamin C RDA Humans, unlike most animals, are unable to synthesize vitamin C on their own, so it is an essential dietary Additional Jost Ascorbate Offerings component. Magnesium Ascorbate Manganese Ascorbate Age Male Female Pregnancy Lactation

0–6 months 40 mg* 40 mg* Groups at Risk of Vitamin C Inadequacy 7–12 months 50 mg* 50 mg* Smokers and passive “smokers” Infants fed evaporated or boiled milk 1–3 years 15 mg 15 mg Individuals with limited food variety 4–8 years 25 mg 25 mg People with malabsorption and certain chronic diseases 9–13 years 45 mg 45 mg

14–18 years 75 mg 65 mg 80 mg 115 mg

19+ years 90 mg 75 mg 85 mg 120 mg * Adequate Intake (AI)

(Internet source: National Institutes of Health; Office of Dietary Supplements and references there-in, EU Register of nutrition and health claims made on foods)

Zinc Ascorbate Glycinate 1. Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical interventions in aging, 13, 757–772. 2. Persaud, C., Forrester, T., & Jackson, A. A. (1996). Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe childhood malnutrition and responds to supplemental glycine. The Journal of nutrition, 126(11), 2823–2830. 3. McCarty, M. F., O’Keefe, J. H., & DiNicolantonio, J. J. (2018). Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection. The Ochsner journal, 18(1), 81–87. 4. Branch J. D. (2003). Effect of creatine supplementation on body composition and performance: a meta-analysis. International journal of sport nutrition and exercise metabolism, 13(2), 198–226. https://doi.org/10.1123/ijsnem.13.2.198 5. Chilibeck, P. D., Kaviani, M., Candow, D. G., & Zello, G. A. (2017). Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis. Open access journal of sports medicine, 8, 213–226. https://doi.org/10.2147/OAJSM.S123529 6. Lanhers, C., Pereira, B., Naughton, G., Trousselard, M., Lesage, F. X., & Dutheil, F. (2017). Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis. Sports medicine (Auckland, N.Z.), 47(1), 163–173. https://doi.org/10.1007/s40279-016-0571-4 7. Chilibeck, P. D., Candow, D. G., Landeryou, T., Kaviani, M., & Paus-Jenssen, L. (2015). Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women. Medicine and science in sports and exercise, 47(8), 1587–1595. 8. Avgerinos, K. I., Spyrou, N., Bougioukas, K. I., & Kapogiannis, D. (2018). Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Experimental gerontology, 108, 166–173. 9. Krei3der, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., Candow, D. G., Kleiner, S. M., Almada, A. L., & Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. 10. Kalhan, S. C., Gruca, L., Marczewski, S., Bennett, C., & Kummitha, C. (2016). Whole body creatine and protein kinetics in healthy men and women: effects of creatine and amino acid supplementation. Amino acids, 48(3), 677–687. 11. González-Ortiz, M., Medina-Santillán, R., Martínez-Abundis, E., & von Drateln, C. R. (2001). Effect of glycine on insulin secretion and action in healthy first-degree relatives of type 2 diabetes mellitus patients. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 33(6), 358–360. 12. Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology, 27(1), 47–55. 13. Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., Deitch, J. R., Sherbondy, P. S., & Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current medical research and opinion, 24(5), 1485–1496. https://doi.org/10.1185/030079908x291967 14. Elam, M. L., Johnson, S. A., Hooshmand, S., Feresin, R. G., Payton, M. E., Gu, J., & Arjmandi, B. H. (2015). A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial. Journal of medicinal food, 18(3), 324–331. https://doi.org/10.1089/jmf.2014.0100

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