DOCSLIB.ORG

A Study on Rheological Properties of Blood and Improvements with High-Voltage Plasma Discharge

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
A Study on Rheological Properties of Blood and Improvements with High-Voltage Plasma Discharge A Study on Rheological Properties of Blood and Improvements with High-Voltage Plasma Discharge A Thesis Submitted to the Faculty of Drexel University by Jin Mu Jung in partial fulfillment of the requirements for the degree of Doctor of Philosophy May 2012 © Copyright 2012 Jin Mu Jung. All Rights Reserved. iii Acknowledgement I would like to express my greatest gratitude to my adviser Prof. Young I. Cho. His kind help, full support, and sincere advice enabled me to achieve my research goal during my years at Drexel University. His guidance has always led me to the right direction and taught me how to explore solutions to the questions with a creative thinking, a process which was one of the biggest learnings in my life so far. I also would like to convey my deep appreciation to Prof. Alexander Fridman, with whom I have a great pleasure and luck to have worked. I have been always amazed at not only the depth of his profound knowledge in plasma chemistry but also his broad understanding in both science and engineering. Also, I am deeply grateful to Profs. Ying Sun, Mikhail Pekker, and Greg Fridman for their valuable advice as committee members. Without their sincere endeavors and support, it would not have been possible to complete my Ph.D. program. I am very thankful to my friends and colleagues at A.J. Drexel Plasma Institute. During the years at DPI, I have experienced both the value of true friendship and the warmth of encouragement, which will make me smile whenever I look back to the days at DPI. Special thanks to Hyoungsup Kim, Yong Yang, Alla, Yelena, Kamau, Nathan, Natalie and Ivan with their endless help. I feel thankful to my friends (Jonghyun Oh, Dalhyoung Kim and his family, Hwabok Wee and his family, Hojun Shin, and Hoyeon Lee and his family) who have always offered a true word of encouragement. Best of all, I can’t find the words to thank my family enough for all the support, understanding, and love during the years of my study. iv Table of Contents List of Figures ....................................................................................................... vii List of Tables ........................................................................................................ xiii Abstract ................................................................................................................ xiv CHAPTER 1: INTRODUCTION ..................................................................................... 17 1.1 Needs to Study Blood Viscosity ................................................................ 17 1.1.1 Introduction to Blood Viscosity ....................................................... 17 1.1.2 Significance of Blood Viscosity Related to Cardiovascular Disease 18 1.2. Methods to Measure Blood Viscosity ....................................................... 24 1.2.1 Conventional Methods to Measure Blood Viscosity ........................ 24 1.2.1 Scanning Capillary Tube Viscometer (SCTV) ................................. 26 1.3 Objectives of the Present Study ................................................................. 29 CHAPTER 2: A NEW HEMATOCRIT-CORRECTION MODEL ........................... 31 2.1 Motivations and Literature Survey on the Correction of WBV ................ 31 2.2 Methods ..................................................................................................... 39 2.2.1 Sample Preparation .......................................................................... 39 2.2.1 Measurement of WBV and Plasma Viscosity ................................... 41 2.2.3 Data Analysis .................................................................................... 42 2.3 Results and Discussion .............................................................................. 44 2.3.1. A New Procedure to Correct the Measured WBV ........................... 44 2.3.2 The Comparison of a New Hematocrit-Correction Model to the Matrai’s Model .......................................................................................... 56 2.4 Limitations ................................................................................................. 78 v CHAPTER 3: A NEW ON-LINE CONDUCTANCE CELL FOR HEMATOCRIT MEASUREMENTS ...................................................... 79 3.1 Motivations and Literature Survey on Hematocrit Measurement ............. 79 3.2 Methods ..................................................................................................... 82 3.2.1 Experimental Setup .......................................................................... 82 3.2.2 Description of Power Supply and Signal Analyzer .......................... 86 3.2.3 Sample Preparation .......................................................................... 88 3.2.4 Experimental Procedure ................................................................... 89 3.2.5 Statistical Analysis ........................................................................... 91 3.3 Results and Discussion .............................................................................. 91 3.4 Limitations ............................................................................................... 105 CHAPTER 4: PLASAMA DISCAHRGE TREATMENT TO IMPROVE HEMORHEOLOGYCAL PROPERTIES ............................................ 106 4.1 Motivations and Literature Survey on Reduction of Blood Viscosity ..... 106 4.2 The Effect of DBD Treatment on Blood Viscosity .................................. 107 4.2.1 Methods .......................................................................................... 107 4.2.2 Results and Discussion ....................................................................112 4.3 The Effect of Corona Discharge Treatment on Blood Viscosity ............. 123 4.3.1 Methods .......................................................................................... 123 4.3.2. Results and Discussion .................................................................. 128 4.4 Limitations ............................................................................................... 144 CHAPTER 5: A STANDARD VISCOSITY FLUID FOR BLOOD VISCOSITY MEASUREMENTS .................................................................................. 146 vi 5.1 Motivations and Literature Survey on a Standard Viscosity Fluid for Blood Viscosity Measurements ............................................................... 146 5.2 Experimental Methods ............................................................................. 151 5.2.1 Sample Preparation ........................................................................ 151 5.2.2 Experimental Procedures ................................................................ 153 5.3 Results and Discussion ............................................................................ 154 5.3.1 Viscosity Profiles of SVFs ............................................................. 154 5.3.2 Dye Concentration .......................................................................... 158 5.3.3 Repeatability Test ........................................................................... 159 5.3.4 Degradation Test with/without EDTA ............................................ 165 5.4 Limitations ............................................................................................... 173 CHAPTER 6: CONCLUSIONS .................................................................................... 175 6.1 A New Hematocrit-Correction Model ..................................................... 175 6.2 A New On-Line Conductance Cell for Hematocrit Measurements ......... 176 6.3 Plasma Discharge Treatment to Improve Hemorheological Properties ... 176 6.4 A Standard Viscosity Fluid for Blood Viscosity Measurements .............. 177 List of References ................................................................................................ 179 VITA .................................................................................................................... 191 vii List of Figures Figure 1-1. Deaths due to cardiovascular disease in the United States between 1900-2007 (source: National Center for Health Statistics & AHA) [4] ................ 19 Figure 1-2. Percentage breakdown of deaths due to cardiovascular disease in the United States in 2007 (source: National Heart, Lung, and Blood Institute from National Center for Health Statistics reports and AHA) [4] ................................. 19 Figure 1-3. Cardiovascular disease deaths versus cancer deaths by age of the United States in 2007 (source: National Center for Health Statistics & AHA & Xu et al) [4, 5] ....................................................................................................... 20 Figure 1-4. Curves of WBV versus shear rates from 1 to 1,000 s-1 for normal and hardened RBCs in blood plasma [1, 2] ........................................................... 25 Figure 1-5. Schematic diagram of the SCTV system for blood viscosity measurement used in the present study [41, 43] ................................................... 27 Figure 2-1. Differences in blood viscosity between native hematocrit (left) and corrected hematocrit (right) cases for control, stable angina, unstable angina and acute myocardial infarction patients [47] .............................................................. 34 Figure 2-2. Magnetic resonance angiography (MRA) image (top left) and meshed model of a carotid bifurcation (top right) with the results of a numerical simulation
Load more

Recommended publications
  • Glossary Physics (I-Introduction)
    1 Glossary Physics (I-introduction) - Efficiency: The percent of the work put into a machine that is converted into useful work output; = work done / energy used [-]. = eta In machines: The work output of any machine cannot exceed the work input (<=100%); in an ideal machine, where no energy is transformed into heat: work(input) = work(output), =100%. Energy: The property of a system that enables it to do work. Conservation o. E.: Energy cannot be created or destroyed; it may be transformed from one form into another, but the total amount of energy never changes. Equilibrium: The state of an object when not acted upon by a net force or net torque; an object in equilibrium may be at rest or moving at uniform velocity - not accelerating. Mechanical E.: The state of an object or system of objects for which any impressed forces cancels to zero and no acceleration occurs. Dynamic E.: Object is moving without experiencing acceleration. Static E.: Object is at rest.F Force: The influence that can cause an object to be accelerated or retarded; is always in the direction of the net force, hence a vector quantity; the four elementary forces are: Electromagnetic F.: Is an attraction or repulsion G, gravit. const.6.672E-11[Nm2/kg2] between electric charges: d, distance [m] 2 2 2 2 F = 1/(40) (q1q2/d ) [(CC/m )(Nm /C )] = [N] m,M, mass [kg] Gravitational F.: Is a mutual attraction between all masses: q, charge [As] [C] 2 2 2 2 F = GmM/d [Nm /kg kg 1/m ] = [N] 0, dielectric constant Strong F.: (nuclear force) Acts within the nuclei of atoms: 8.854E-12 [C2/Nm2] [F/m] 2 2 2 2 2 F = 1/(40) (e /d ) [(CC/m )(Nm /C )] = [N] , 3.14 [-] Weak F.: Manifests itself in special reactions among elementary e, 1.60210 E-19 [As] [C] particles, such as the reaction that occur in radioactive decay.
    [Show full text]
  • Plasma Physics I APPH E6101x Columbia University Fall, 2016
    Lecture 1: Plasma Physics I APPH E6101x Columbia University Fall, 2016 1 Syllabus and Class Website http://sites.apam.columbia.edu/courses/apph6101x/ 2 Textbook “Plasma Physics offers a broad and modern introduction to the many aspects of plasma science … . A curious student or interested researcher could track down laboratory notes, older monographs, and obscure papers … . with an extensive list of more than 300 references and, in particular, its excellent overview of the various techniques to generate plasma in a laboratory, Plasma Physics is an excellent entree for students into this rapidly growing field. It’s also a useful reference for professional low-temperature plasma researchers.” (Michael Brown, Physics Today, June, 2011) 3 Grading • Weekly homework • Two in-class quizzes (25%) • Final exam (50%) 4 https://www.nasa.gov/mission_pages/sdo/overview/ Launched 11 Feb 2010 5 http://www.nasa.gov/mission_pages/sdo/news/sdo-year2.html#.VerqQLRgyxI 6 http://www.ccfe.ac.uk/MAST.aspx http://www.ccfe.ac.uk/mast_upgrade_project.aspx 7 https://youtu.be/svrMsZQuZrs 8 9 10 ITER: The International Burning Plasma Experiment Important fusion science experiment, but without low-activation fusion materials, tritium breeding, … ~ 500 MW 10 minute pulses 23,000 tonne 51 GJ >30B $US (?) DIII-D ⇒ ITER ÷ 3.7 (50 times smaller volume) (400 times smaller energy) 11 Prof. Robert Gross Columbia University Fusion Energy (1984) “Fusion has proved to be a very difficult challenge. The early question was—Can fusion be done, and, if so how? … Now, the challenge lies in whether fusion can be done in a reliable, an economical, and socially acceptable way…” 12 http://lasco-www.nrl.navy.mil 13 14 Plasmasphere (Image EUV) 15 https://youtu.be/TaPgSWdcYtY 16 17 LETTER doi:10.1038/nature14476 Small particles dominate Saturn’s Phoebe ring to surprisingly large distances Douglas P.
    [Show full text]
  • Plasma Physics and Advanced Fluid Dynamics Jean-Marcel Rax (Univ. Paris-Saclay, Ecole Polytechnique), Christophe Gissinger (LPEN
    Plasma Physics and advanced fluid dynamics Jean-Marcel Rax (Univ. Paris-Saclay, Ecole Polytechnique), Christophe Gissinger (LPENS)) I- Plasma Physics : principles, structures and dynamics, waves and instabilities Besides ordinary temperature usual (i) solid state, (ii) liquid state and (iii) gaseous state, at very low and very high temperatures new exotic states appear : (iv) quantum fluids and (v) ionized gases. These states display a variety of specific and new physical phenomena : (i) at low temperature quantum coherence, correlation and indiscernibility lead to superfluidity, su- perconductivity and Bose-Einstein condensation ; (ii) at high temperature ionization provides a significant fraction of free charges responsible for in- stabilities, nonlinear, chaotic and turbulent behaviors characteristic of the \plasma state". This set of lectures provides an introduction to the basic tools, main results and advanced methods of Plasma Physics. • Plasma Physics : History, orders of magnitudes, Bogoliubov's hi- erarchy, fluid and kinetic reductions. Electric screening : Langmuir frequency, Maxwell time, Debye length, hybrid frequencies. Magnetic screening : London and Kelvin lengths. Alfven and Bohm velocities. • Charged particles dynamics : adiabaticity and stochasticity. Alfven and Ehrenfest adiabatic invariants. Electric and magnetic drifts. Pon- deromotive force. Wave/particle interactions : Chirikov criterion and chaotic dynamics. Quasilinear kinetic equation for Landau resonance. • Structure and self-organization : Debye and Child-Langmuir sheath, Chapman-Ferraro boundary layer. Brillouin and basic MHD flow. Flux conservation : Alfven's theorem. Magnetic topology : magnetic helicity conservation. Grad-Shafranov and basic MHD equilibrium. • Waves and instabilities : Fluid and kinetic dispersions : resonance and cut-off. Landau and cyclotron absorption. Bernstein's modes. Fluid instabilities : drift, interchange and kink. Alfvenic and geometric coupling.
    [Show full text]
  • Plasma Descriptions I: Kinetic, Two-Fluid 1
    CHAPTER 5. PLASMA DESCRIPTIONS I: KINETIC, TWO-FLUID 1 Chapter 5 Plasma Descriptions I: Kinetic, Two-Fluid Descriptions of plasmas are obtained from extensions of the kinetic theory of gases and the hydrodynamics of neutral uids (see Sections A.4 and A.6). They are much more complex than descriptions of charge-neutral uids because of the complicating eects of electric and magnetic elds on the motion of charged particles in the plasma, and because the electric and magnetic elds in the plasma must be calculated self-consistently with the plasma responses to them. Additionally, magnetized plasmas respond very anisotropically to perturbations — because charged particles in them ow almost freely along magnetic eld lines, gyrate about the magnetic eld, and drift slowly perpendicular to the magnetic eld. The electric and magnetic elds in a plasma are governed by the Maxwell equations (see Section A.2). Most calculations in plasma physics assume that the constituent charged particles are moving in a vacuum; thus, the micro- scopic, “free space” Maxwell equations given in (??) are appropriate. For some applications the electric and magnetic susceptibilities (and hence dielectric and magnetization responses) of plasmas are derived (see for example Sections 1.3, 1.4 and 1.6); then, the macroscopic Maxwell equations are used. Plasma eects enter the Maxwell equations through the charge density and current “sources” produced by the response of a plasma to electric and magnetic elds: X X q = nsqs, J = nsqsVs, plasma charge, current densities. (5.1) s s Here, the subscript s indicates the charged particle species (s = e, i for electrons, 3 ions), ns is the density (#/m ) of species s, qs the charge (Coulombs) on the species s particles, and Vs the species ow velocity (m/s).
    [Show full text]
  • Rheology of Human Blood Plasma: Viscoelastic Versus Newtonian Behavior
    week ending PRL 110, 078305 (2013) PHYSICAL REVIEW LETTERS 15 FEBRUARY 2013 Rheology of Human Blood Plasma: Viscoelastic Versus Newtonian Behavior M. Brust,1 C. Schaefer,1 R. Doerr,1 L. Pan,2 M. Garcia,2 P.E. Arratia,2 and C. Wagner1,* 1Experimentalphysik, Universita¨t des Saarlandes, Postfach 151150, 66041 Saarbru¨cken, Germany 2Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA (Received 16 August 2012; revised manuscript received 5 December 2012; published 15 February 2013) We investigate the rheological characteristics of human blood plasma in shear and elongational flows. While we can confirm a Newtonian behavior in shear flow within experimental resolution, we find a viscoelastic behavior of blood plasma in the pure extensional flow of a capillary breakup rheometer. The influence of the viscoelasticity of blood plasma on capillary blood flow is tested in a microfluidic device with a contraction-expansion geometry. Differential pressure measurements revealed that the plasma has a pronounced flow resistance compared to that of pure water. Supplementary measurements indicate that the viscoelasticity of the plasma might even lead to viscoelastic instabilities under certain conditions. Our findings show that the viscoelastic properties of plasma should not be ignored in future studies on blood flow. DOI: 10.1103/PhysRevLett.110.078305 PACS numbers: 83.50.Jf, 83.60.Wc, 87.19.UÀ Blood is a complex fluid that consists of a suspension of microfluidic devices. The two investigated blood replace- blood cells in a liquid plasma which contains mostly water ment solutions with the same shear but different elonga- as well as proteins, mineral ions, hormones, and glucose.
    [Show full text]
  • In Vitro Demonstration of Cancer Inhibiting Properties from Stratified Self-Organized Plasma-Liquid Interface
    www.nature.com/scientificreports OPEN In vitro Demonstration of Cancer Inhibiting Properties from Stratifed Self-Organized Plasma-Liquid Received: 2 March 2017 Accepted: 11 September 2017 Interface Published: xx xx xxxx Zhitong Chen1, Shiqiang Zhang1, Igor Levchenko2,3, Isak I. Beilis4 & Michael Keidar1 Experiments on plasma-liquid interaction and formation of thinly stratifed self-organized patterns at plasma-liquid interface have revealed a nontrivial cancer-inhibiting capability of liquid media treated at self-organized interfacial patterns. A pronounced cancer suppressing activity towards at least two cancer cells, breast cancer MDA-MB-231 and human glioblastoma U87 cancer lines, was demonstrated in vitro. After a short treatment at the thinly stratifed self-organized plasma-liquid interface pattern, the cancer inhibiting media demonstrate pronounced suppressing and apoptotic activities towards tumor cells. Importantly, this would have been impossible without interfacial stratifcation of plasma jet to thin (of several µm) current flaments, which plays a pivotal role in building up the cancer inhibition properties. Furthermore, thinly stratifed, self-organized interfacial discharge is capable to efciently control the ROS and RNS concentrations in the cancer-inhibiting media. In particular, abnormal ROS/ RNS ratios are not achievable in discharges since they do not form stratifed thin-flament patterns. Our fndings could be tremendously important for understanding the cancer proliferation problem and hence, the potential of this approach in tackling the challenges of high cancer-induced mortality should be explored. Despite tremendous eforts undertaken, cancer and cancer-related diseases still remain among the most dan- gerous and mortiferous abnormalities responsible for about 13% of human death cases, totally accounting for more than 7 million per year1.
    [Show full text]
  • Research Report
    INSTITUTE OF PLASMA PHYSICS NAOOYA UNIVERSITY Equations for a Plasma Consisting of Matter and Antimatter A. H. Nelson and K. Ikuta IPPJ-131 August 1972 RESEARCH REPORT NAGOYA, JAPAN Equations for a Plasma Consisting of Matter and Antimatter A. H. Nelson end K. Ikuta IPPJ-131 August 1972 Further communication about this report is to be sent to the Research Information Center, Institute of Plasma Physics, Nagoya Uniyersity, Nagoya, JAPAN. Contents Page Abstract 1)Introduction 1 2)Basic Equations 3 2.1) Individual Particle Equations 5 2.2) Ambiplasma Equations 10 2.3) Oebye length in an Ambiplasma 23 3)Waves in an Ambiplasma 25 3.1) Linearized, Cnllisionless Equations 25 3.2) Longitudinal Waves with Bo = 0 28 3.2.1) The dispersion relations 28 3.2.2) Plasma type waves 31 3.2.3) Acoustic type waves 33 3.3) Transverse waves with Bo * k = 0 33 3.3.1) The dispersion relation 33 T.3.2) High Frequency waves 35 3.3.3) Low Frequency waves 39 References 40 ' Figure 1 41 Acknowledgement 42 Abstract A set of fluid type equations is derived to describe the macroscopic behaviour of a plasma consisting of a mixture of matter and antimatter •> The equations ?xe written in a form which displays the full symmetry of the medium with respect to particle charge and mass, a symmetry absent in normal plasmas. This symmetry of the equations facilitates their manipulation and solution, and by way of illustration the equations are used to analyze the propagation of electromagnetic and acoustic waves through a matter-antimatter plasma.
    [Show full text]
  • Fluid Model of Plasma and Computational Methods for Solution E
    WDS'06 Proceedings of Contributed Papers, Part III, 180–186, 2006. ISBN 80-86732-86-X © MATFYZPRESS Fluid Model of Plasma and Computational Methods for Solution E. Havl´ıˇckov´a Charles University, Faculty of Mathematics and Physics, V Holeˇsoviˇck´ach 2, 180 00 Prague, Czech Republic. Abstract. This contribution gives basic insight into the fluid modelling in plasma physics. The main aim of the paper is to offer brief conspectus of equations that form the fluid model of plasma and to point out the differences between the theoretical model in general form as derived from the Boltzmann equation and the fluid model which is commonly used in practical simulations. Second part of the contribution summarizes computational methods which are often used for solution of the described model, as they were the most widely mentioned in literature. Introduction The simulation of plasma processes can be based on various approaches. The microscopic description of plasma is for many practical purposes too detailed or computationally too complicated and in some applications we need not to know the information about the behaviour of individual particles. Fluid model describes macroscopic plasma phenomena and reveals how the statistical plasma parameters evolve in time and space. Fluid model of plasma Theoretical description of plasma Fluid model of plasma is based on partial differential equations (PDEs) which describe the macro- scopic quantities such as density, flux, average velocity, pressure, temperature or heat flux. Governing PDEs can be derived from the Boltzmann equation (BE) by taking velocity moments. Zero moment of ∞ + 3 the Boltzmann equation ( −∞ (BE) d v) yields continuity equation for the particle density R ∂n Qρ + ∇ · (n~u) = (1) ∂t m ∞ ∞ + 3 1 + 3 Density and average velocity are defined as n = −∞ f d v and ~u = n −∞ ~vf d v.
    [Show full text]
  • Phenomenological Review on Quark–Gluon Plasma: Concepts Vs
    Review Phenomenological Review on Quark–Gluon Plasma: Concepts vs. Observations Roman Pasechnik 1,* and Michal Šumbera 2 1 Department of Astronomy and Theoretical Physics, Lund University, SE-223 62 Lund, Sweden 2 Nuclear Physics Institute ASCR 250 68 Rez/Prague,ˇ Czech Republic; [email protected] * Correspondence: [email protected] Abstract: In this review, we present an up-to-date phenomenological summary of research developments in the physics of the Quark–Gluon Plasma (QGP). A short historical perspective and theoretical motivation for this rapidly developing field of contemporary particle physics is provided. In addition, we introduce and discuss the role of the quantum chromodynamics (QCD) ground state, non-perturbative and lattice QCD results on the QGP properties, as well as the transport models used to make a connection between theory and experiment. The experimental part presents the selected results on bulk observables, hard and penetrating probes obtained in the ultra-relativistic heavy-ion experiments carried out at the Brookhaven National Laboratory Relativistic Heavy Ion Collider (BNL RHIC) and CERN Super Proton Synchrotron (SPS) and Large Hadron Collider (LHC) accelerators. We also give a brief overview of new developments related to the ongoing searches of the QCD critical point and to the collectivity in small (p + p and p + A) systems. Keywords: extreme states of matter; heavy ion collisions; QCD critical point; quark–gluon plasma; saturation phenomena; QCD vacuum PACS: 25.75.-q, 12.38.Mh, 25.75.Nq, 21.65.Qr 1. Introduction Quark–gluon plasma (QGP) is a new state of nuclear matter existing at extremely high temperatures and densities when composite states called hadrons (protons, neutrons, pions, etc.) lose their identity and dissolve into a soup of their constituents—quarks and gluons.
    [Show full text]
  • Surface Tension of Blood Serum, and the Determination of the Surface Tension of Biological Fluids
    THE SURFACE TENSION OF BLOOD SERUM, AND THE DETERMINATION OF THE SURFACE TENSION OF BIOLOGICAL FLUIDS BY HENRY N. HARK-INS A WILLIAM D. HARKINS (From the Departmni of Chemistry, University of Chicago, Chizago) (Received for publication January 4, 1929) INTRODUCTION This investigation was undertaken in order to obtain a more exact knowledge of the surface tension of undiluted blood serum, and its variation under various clinical conditions, than is given by the work reported earlier by others (1-12). It was found that practically all previous investigators have made errors in the experimental procedure or in the calculation of their results, usually in both, of such a high magnitude as to make their data almost entirely worthless. Thus a new field is opened up for future investigation. The mean value obtained for the surface tension of undiluted normal blood serum is 52 dynes per centimeter at 200 and 48 dynes at 370C. The result at the higher temperature agrees moderately well with the mean value found by Morgan and Woodward (7), but it is known that the method by which their results were calculated gives values which are too low. The average of all of their values at 370 is 45.5 while the average of all of our results is 46.2. However, their work repre- sents a great forward step, as it is of a much higher degree of accuracy than that of any of the other earlier investigators. Almost all of the values obtained by others are of an altogether different order of magni- tude, since they are from 10 to 20 dynes too high.
    [Show full text]
  • Computational Fluid Dynamics Analysis of Cold Plasma Plume Mixing with Blood Using Level Set Method Coupled with Heat Transfer
    applied sciences Article Computational Fluid Dynamics Analysis of Cold Plasma Plume Mixing with Blood Using Level Set Method Coupled with Heat Transfer Mehrdad Shahmohammadi Beni and Kwan Ngok Yu * Department of Physics and Materials Science, City University of Hong Kong, Hong Kong, China; [email protected] * Correspondence: [email protected]; Tel.: +852-3442-7182 Academic Editor: Xianchang Li Received: 27 April 2017; Accepted: 31 May 2017; Published: 3 June 2017 Abstract: Cold plasmas were proposed for treatment of leukemia. In the present work, conceptual designs of mixing chambers that increased the contact between the two fluids (plasma and blood) through addition of obstacles within rectangular-block-shaped chambers were proposed and the dynamic mixing between the plasma and blood were studied using the level set method coupled with heat transfer. Enhancement of mixing between blood and plasma in the presence of obstacles was demonstrated. Continuous tracking of fluid mixing with determination of temperature distributions was enabled by the present model, which would be a useful tool for future development of cold plasma devices for treatment of blood-related diseases such as leukemia. Keywords: level set method; thermofluid; plasma medicine; cold plasma; multiphase flow 1. Introduction A novel technique and a conceptual design of a mixing chamber were presented in the current study that could be used in future development of effective cold plasma devices for treatment of blood related syndromes such as leukemia. Plasma medicine research has been progressing very rapidly in recent years [1–3]. Cold atmospheric plasmas have shown significant potentials in various biomedical applications such as wound healing [4,5], tooth bleaching [6], cancer therapy [7–9] and sterilization of infected tissues [10].
    [Show full text]
  • Quark-Gluon Plasma and the Early Universe
    Chapter 2 Quark-Gluon Plasma and the Early Universe There is now considerable evidence that the universe began as a fireball, the so called “Big-Bang”, with extremely high temperature and high energy density. At early enough times, the temperature was certainly high enough (T > 100 GeV) that all the known particles (including quarks, leptons, gluons, photons, Higgs bosons, W and Z) were extremely relativistic. Even the “strongly inter- acting” particles, quarks and gluons, would interact fairly weakly due to asymptotic freedom and perturbation theory should be sufficient to describe them. Thus this was a system of hot, weakly interacting color-charged particles, a quark-gluon plasma (QGP), in equilibrium with the other species. Due to asymptotic freedom, at sufficiently high temperature the quark-gluon plasma can be well-described using statistical mechanics as a free relativistic parton gas. In this Chapter, we explore the physics of QGP, perhaps the simplest system of strong-interaction particles that exists in the context of QCD. As the universe cooled during the subsequent expansion phase, the quarks, antiquarks, and gluons combined to form hadrons resulting in the baryonic matter that we observe today. The transition from quarks and gluons to baryons is a fascinating subject that has been difficult to address quantitatively. However, we will discuss this transition by considering the basic physics issues without treating the quantitative details. At present there is a substantial effort in theoretical physics to address this transition by using high-level computational methods known as lattice gauge theory. This subject is somewhat technical and we will discuss it only very briefly.
    [Show full text]