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205 (10) J Immunol 2020; 205:2555-2935; ; http://www.jimmunol.org/content/205/10 This information is current as of September 28, 2021. Downloaded from Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists http://www.jimmunol.org/ • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription by guest on September 28, 2021 Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. VOL. 205 | NO. 10 | November 15, 2020 | Pages 2555–2938 TOP READS 2555 Notch Regulation of Human NK Cell Development See article p. 2679 Anti-Inflammatory Extracellular Membrane Vesicles See article p. 2707 SIRPa Deficiency Promotes Hemophagocytic Lymphohistiocytosis See article p. 2821 C5aR2 Is Protective in Gut Ischemia Reperfusion Injury See article p. 2834 41BB Ab Induces Tumor Regression See article p. 2893 Combination Therapy for Colorectal Cancer See article p. 2905 BRIEF REVIEWS Downloaded from 2557 Regulatory T Cells in Angiogenesis Zala Luznik, Sonia Anchouche, Reza Dana, and Jia Yin 2566 Immune Response Resetting as a Novel Strategy to Overcome SARS-CoV-2–Induced Cytokine Storm Alexandre E. Nowill and Pedro O. de Campos-Lima http://www.jimmunol.org/ CUTTING EDGE 2577 Cutting Edge: Tissue Antigen Expression Levels Fine-Tune T Cell Differentiation Decisions In Vivo Douglas F. Pinheiro, Antal B. Szenes-Nagy, Megan M. Maurano, Melanie Lietzenmayer, Maria M. Klicznik, Raimund Holly, Daniel Kirchmeier, Sophie Kitzmueller, Gertrude Achatz-Straussberger, Michael D. Rosenblum, Josef Thalhamer, Abul K. Abbas, and Iris K. Gratz by guest on September 28, 2021 ANTIGEN RECOGNITION AND RESPONSES 2583 Polyglutamine-Related Aggregates Can Serve as a Potent Antigen Source for Cross-Presentation by Dendritic Cells Shira Tabachnick-Cherny, Sivan Pinto, Dikla Berko, Caterina Curato, Yochai Wolf, Ziv Porat, Rotem Karmona, Boaz Tirosh, Steffen Jung, and Ami Navon On the cover: Immunohistochemical staining was performed to evaluate Myo9b expression in pleural metastatic tissue sections with anti-Myo9b mAbs. Lung cancer patients with malignant pleural effusion had higher Myo9b expression levels in pleural metastatic tissues than in primary lung cancer tissues or the adjacent normal tissues. Yi, F.-S., X. Zhang, K. Zhai, Z.-Y. Huang, X.-Z. Wu, M.-T. Wu, X.-Y. Shi, X.-B. Pei, S.-F. Dong, W. Wang, Y. Yang, J. Du, Z.-T. Luo, and H.-Z. Shi. 2020. TSAd plays a major role in Myo9b-mediated suppression of malignant pleural effusion by regulating TH1/TH17 cell response. J. Immunol. 205: 2926–2935. The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852, Phone: 301-634-7197, Fax: 301-246-8401. Subscription terms: New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscription for prices and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/ membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issues can be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/Subscription/Claims). Reprints of individual articles are available only from authors. Periodicals postage paid at Rockville, MD 20852, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes 60 days in advance to The Journal of Immunology, Subscription Department, 1451 Rockville Pike, Suite 650, Rockville, MD 20852. Copyright Ó 2020 by The American Association of Immunologists, Inc. AUTOIMMUNITY 2595 Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis Marina A. Korn, Heike Schmitt, Sieglinde Angermu¨ller, David Chambers, Michaela Seeling, Uwe T. Lux, Stefanie Brey, Dmytro Royzman, Christin Bru¨ckner, Vanessa Popp, Elena Percivalle, Tobias Ba¨uerle, Elisabeth Zinser, Thomas H. Winkler, Alexander Steinkasserer, Falk Nimmerjahn, and Lars Nitschke 2606 Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds)RNAs Is Markedly Decreased in Multiple Sclerosis and Unedited Alu dsRNAs Are Potent Activators of Proinflammatory Transcriptional Responses John T. Tossberg, Rachel M. Heinrich, Virginia M. Farley, Philip S. Crooke, III, and Thomas M. Aune CLINICAL AND HUMAN IMMUNOLOGY 2618 Innate Immune Responses and Gut Microbiomes Distinguish HIV-Exposed from HIV-Unexposed Children in a Population-Specific Manner Nelly Amenyogbe, Pedro Dimitriu, Patricia Cho, Candice Ruck, Edgardo S. Fortuno, III, Bing Cai, Ariane Alimenti, Helene C. F. Cot^e, Evelyn J. Maan, Amy L. Slogrove, Monika Esser, Arnaud Marchant, Tessa Goetghebuer, Casey P. Shannon, Scott J. Tebbutt, Tobias R. Kollmann, William W. Mohn, and Kinga K. Smolen 2629 Effect of Ibrutinib on the IFN Response of Chronic Lymphocytic Leukemia Cells Meihui Xia, Tina Yuxuan Luo, Yonghong Shi, Guizhi Wang, Hubert Tsui, Daniel Harari, and David E. Spaner Downloaded from IMMUNE REGULATION 2640 IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators € Marc Wehrli, Christoph Schneider, Fabiola Cortinas-Elizondo, Danielle Verschoor, Kayluz Frias Boligan, http://www.jimmunol.org/ Olivia Joan Adams, Ruslan Hlushchuk, Christine Engelmann, Fritz Daudel, Peter M. Villiger, Frank Seibold, Nikhil Yawalkar, Cedric Vonarburg, Sylvia Miescher, Marius Lo¨tscher,Thomas Kaufmann, Christian Mu¨nz, Christoph Mueller, Valentin Djonov, Hans-Uwe Simon, and Stephan von Gunten 2649 Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity Yanbo Sun, Nicholas K. Preiss, Kristine B. Valenteros, Yasmin Kamal, Young-Kwang Usherwood, H. Robert Frost, and Edward J. Usherwood by guest on September 28, 2021 2667 Regulatory T Cells Maintain Selective Access to IL-2 and Immune Homeostasis despite Substantially Reduced CD25 Function Erika T. Hayes, Cassidy E. Hagan, Liliane Khoryati, Marc A. Gavin, and Daniel J. Campbell IMMUNE SYSTEM DEVELOPMENT 2679 Notch Regulates Innate Lymphoid Cell Plasticity during Human NK Cell Development Ansel P. Nalin, Jesse J. Kowalski, Alexander C. Sprague, Blaire K. Schumacher, Adam G. Gerhardt, Youssef Youssef, Kiran V. Vedantam, Xiaoli Zhang, Christian W. Siebel, Emily M. Mace, Michael A. Caligiuri, Bethany L. Mundy-Bosse, and Aharon G. Freud 2694 Macrophage-Derived IL-1b Regulates Emergency Myelopoiesis via the NF-kB and C/ebpb in Zebrafish Zongfang Wei, Chenzheng Li, Yangping Zhang, Chenyu Lin, Yiyue Zhang, Liping Shu, Lingfei Luo, Jian Zhuo, and Li Li IMMUNOTHERAPY AND VACCINES 2707 Human Gut Commensal Membrane Vesicles Modulate Inflammation by Generating M2-like Macrophages and Myeloid-Derived Suppressor Cells Esin Alpdundar Bulut, Banu Bayyurt Kocabas, Volkan Yazar, Gamze Aykut, Ulku Guler, Bekir Salih, Naz Surucu Yilmaz, Ihsan Cihan Ayanoglu, Muammer Merve Polat, Kamil Can Akcali, Ihsan Gursel, and Mayda Gursel INFECTIOUS DISEASE AND HOST RESPONSE 2719 Discordance between Serum Neutralizing Antibody Titers and the Recovery from COVID-19 Merve Kalkan Yazıcı, Meliha Meric Koc¸, Nesibe Selma C¸etin, Elif Karaaslan, Gulay Okay, Bulent Durdu, Bilge Su¨mbu¨l, and Mehmet Z. Doymaz 2726 Role of Tunneling Nanotube–like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread George Okafo, Silvana Valdebenito, Maribel Donoso, Ross Luu, David Ajasin, Brendan Prideaux, Santhi Gorantla, and Eliseo A. Eugenin 2742 The Presence of Antibody-Dependent Cell Cytotoxicity–Mediating Antibodies in Kaposi Sarcoma–Associated Herpesvirus–Seropositive Individuals Does Not Correlate with Disease Pathogenesis or Progression Lisa K. Poppe, Charles Wood, and John T. West 2750 Airway Macrophages Mediate Mucosal Vaccine–Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection Michael R. D’Agostino, Rocky Lai, Sam Afkhami, Amandeep Khera, Yushi Yao, Maryam Vaseghi-Shanjani, Anna Zganiacz, Mangalakumari Jeyanathan, and Zhou Xing Downloaded from 2763 The Immune System Fails to Mount a Protective Response to Gram-Positive or Gram-Negative Bacterial Prostatitis Federico Lupo, Matthieu Rousseau, Tracy Canton, and Molly A. Ingersoll INNATE IMMUNITY AND INFLAMMATION http://www.jimmunol.org/ 2778 RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling Deepika Sharma, Ankit Malik, Arjun Balakrishnan, R. K. Subbarao Malireddi, and Thirumala-Devi Kanneganti 2786 Non–Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice Lin Lin, Bin-Jin Hwang, Ning Li, Paul Googe, Luis A. Diaz, Ed Miao, Barbara Vilen, Nancy E. Thomas, Jenny Ting, and Zhi Liu by guest on September 28, 2021 2795 Mitochondrial Reactive Oxygen Species Participate in Signaling Triggered by Heme in Macrophages and upon Hemolysis Elisa B.