38 CFR Ch. I (7–1–18 Edition)
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Chloracne: from Clinic to Research
DERMATOLOGICA SINICA 30 (2012) 2e6 Contents lists available at SciVerse ScienceDirect Dermatologica Sinica journal homepage: http://www.derm-sinica.com REVIEW ARTICLE Chloracne: From clinic to research Qiang Ju 1, Kuochia Yang 2, Christos C. Zouboulis 3, Johannes Ring 4, Wenchieh Chen 4,* 1 Department of Dermatology, Shanghai Skin Disease and STD Hospital, Shanghai, People’s Republic of China 2 Department of Dermatology, Changhua Christian Hospital, Changhua, Taiwan 3 Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany 4 Department of Dermatology and Allergy, Technische Universität München, Munich, Germany article info abstract Article history: Chloracne is the most sensitive and specific marker for a possible dioxin (2,3,7,8-tetrachlorodibenzo-p- Received: Oct 31, 2011 dioxin) intoxication. It is clinically characterized by multiple acneiform comedone-like cystic eruptions Revised: Nov 9, 2011 mainly involving face in the malar, temporal, mandibular, auricular/retroauricular regions, and the Accepted: Nov 9, 2011 genitalia, often occurring in age groups not typical for acne vulgaris. Histopathology is essential for adefinite diagnosis, which exhibits atrophy or absence of sebaceous glands as well as infundibular Keywords: dilatation or cystic formation of hair follicles, hyperplasia of epidermis, and hyperpigmentation of aryl hydrocarbon receptor stratum corneum. The appearance of chloracne and its clinical severity does not correlate with the blood chloracne “ ” 2,3,7,8-tetrachlorodibenzo-p-dioxin levels of dioxins. Pathogenesis of chloracne remains largely unclear. An aryl hydrocarbon receptor - polyhalogenated aromatic hydrocarbons mediated signaling pathway affecting the multipotent stem cells in the pilosebaceous units is probably sebaceous gland the major molecular mechanism inducing chloracne. -
Compensation for Occupational Skin Diseases
ORIGINAL ARTICLE http://dx.doi.org/10.3346/jkms.2014.29.S.S52 • J Korean Med Sci 2014; 29: S52-58 Compensation for Occupational Skin Diseases Han-Soo Song1 and Hyun-chul Ryou2 The Korean list of occupational skin diseases was amended in July 2013. The past list was constructed according to the causative agent and the target organ, and the items of that 1 Department of Occupational and Environmental list had not been reviewed for a long period. The revised list was reconstructed to include Medicine, College of Medicine, Chosun University, Gwangju; 2Teo Center of Occupational and diseases classified by the International Classification of Diseases (10th version). Therefore, Environmental Medicine, Changwon, Korea the items of compensable occupational skin diseases in the amended list in Korea comprise contact dermatitis; chemical burns; Stevens-Johnson syndrome; tar-related skin diseases; Received: 19 December 2013 infectious skin diseases; skin injury-induced cellulitis; and skin conditions resulting from Accepted: 2 May 2014 physical factors such as heat, cold, sun exposure, and ionized radiation. This list will be Address for Correspondence: more practical and convenient for physicians and workers because it follows a disease- Han-Soo Song, MD based approach. The revised list is in accordance with the International Labor Organization Department of Occupational and Environmental Medicine, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, list and is refined according to Korean worker’s compensation and the actual occurrence of Gwangju 501-717, Korea occupational skin diseases. However, this revised list does not perfectly reflect the actual Tel: +82.62-220-3689, Fax: +82.62-443-5035 E-mail: [email protected] status of skin diseases because of the few cases of occupational skin diseases, incomplete statistics of skin diseases, and insufficient scientific evidence. -
General Dermatology an Atlas of Diagnosis and Management 2007
An Atlas of Diagnosis and Management GENERAL DERMATOLOGY John SC English, FRCP Department of Dermatology Queen's Medical Centre Nottingham University Hospitals NHS Trust Nottingham, UK CLINICAL PUBLISHING OXFORD Clinical Publishing An imprint of Atlas Medical Publishing Ltd Oxford Centre for Innovation Mill Street, Oxford OX2 0JX, UK tel: +44 1865 811116 fax: +44 1865 251550 email: [email protected] web: www.clinicalpublishing.co.uk Distributed in USA and Canada by: Clinical Publishing 30 Amberwood Parkway Ashland OH 44805 USA tel: 800-247-6553 (toll free within US and Canada) fax: 419-281-6883 email: [email protected] Distributed in UK and Rest of World by: Marston Book Services Ltd PO Box 269 Abingdon Oxon OX14 4YN UK tel: +44 1235 465500 fax: +44 1235 465555 email: [email protected] © Atlas Medical Publishing Ltd 2007 First published 2007 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Clinical Publishing or Atlas Medical Publishing Ltd. Although every effort has been made to ensure that all owners of copyright material have been acknowledged in this publication, we would be glad to acknowledge in subsequent reprints or editions any omissions brought to our attention. A catalogue record of this book is available from the British Library ISBN-13 978 1 904392 76 7 Electronic ISBN 978 1 84692 568 9 The publisher makes no representation, express or implied, that the dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up-to-date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. -
Occupational Skin Disease C.J
Postgraduate Medical Journal (1989) 65, 374- 380 Postgrad Med J: first published as 10.1136/pgmj.65.764.374 on 1 June 1989. Downloaded from Occupational Medicine Occupational skin disease C.J. Stevenson Department ofOccupational Health and Hygiene, University ofNewcastle upon Tyne, Newcastle upon Tyne, UK. Introduction Diagnosis ofoccupational skin disease It is opportune to discuss occupational skin disorders Early diagnosis depends upon awareness of the pos- since recently a 'Save your Skin' Campaign has been sibility that a presenting dermatosis can be occupa- undertaken in the United Kingdom by the Employ- tional in origin. Sometimes the dermatosis is quite ment Advisory Service of the Health and Safety specific for exposure to a chemical, for example the Executive to increase the awareness of employers and lichenoid dermatosis seen in persons working with employees of the need to prevent skin problems in colour developers.3 Sometimes the dermatosis is a industry.' This was justified because skin disorders lookalike of a non-occupational disorder, such as caused by substances at work are the most common vitiligo, and sometimes we are faced with contact occupational health problem. dermatitis which could equally well be due to an Contact dermatitis (eczematous dermatitis of offending substance in the domestic environment. It is predominantly exogenous aetiology) is the com- important to realise that the environment is constantly monest form of occupational skin disease. However, changing and new processes are being introduced. For other occupational skin disorders occur, often presen- example, grass cutting by strimmers is now known to ting to physicians of different disciplines, for example cause a distinctive phytophotodermatosis in some infectious conditions, occupational skin cancer, individuals.4 copyright. -
Acne and Related Conditions
Rosanne Paul, DO Madeline Tarrillion, DO Miesha Merati, DO Gregory Delost, DO Emily Shelley, DO Jenifer R. Lloyd, DO, FAAD American Osteopathic College of Dermatology Disclosures • We do not have any relevant disclosures. Cleveland before June 2016 Cleveland after June 2016 Overview • Acne Vulgaris • Folliculitis & other – Pathogenesis follicular disorders – Clinical Features • Variants – Treatments • Rosacea – Pathogenesis – Classification & clinical features • Rosacea-like disorders – Treatment Acne vulgaris • Pathogenesis • Multifactorial • Genetics – role remains uncertain • Sebum – hormonal stimulation • Comedo • Inflammatory response • Propionibacterium acnes • Hormonal influences • Diet Bolognia et al. Dermatology. 2012. Acne vulgaris • Clinical Features • Face & upper trunk • Non-inflammatory lesions • Open & closed comedones • Inflammatory lesions • Pustules, nodules & cysts • Post-inflammatory hyperpigmentation • Scarring • Pitted or hypertrophic Bolognia et al. Dermatology. 2012. Bolognia et al. Dermatology. 2012. Acne variants • Acne fulminans • Acne conglobata • PAPA syndrome • Solid facial edema • Acne mechanica • Acne excoriée • Drug-induced Bolognia et al. Dermatology. 2012. Bolognia et al. Dermatology. 2012. Bolognia et al. Dermatology. 2012. Bolognia et al. Dermatology. 2012. Acne variants • Occupational • Chloracne • Neonatal acne (neonatal cephalic pustulosis) • Infantile acne • Endocrinological abnormalities • Apert syndrome Bolognia et al. Dermatology. 2012. Bolognia et al. Dermatology. 2012. Acne variants • Acneiform -
(12) United States Patent (10) Patent No.: US 7,359,748 B1 Drugge (45) Date of Patent: Apr
USOO7359748B1 (12) United States Patent (10) Patent No.: US 7,359,748 B1 Drugge (45) Date of Patent: Apr. 15, 2008 (54) APPARATUS FOR TOTAL IMMERSION 6,339,216 B1* 1/2002 Wake ..................... 250,214. A PHOTOGRAPHY 6,397,091 B2 * 5/2002 Diab et al. .................. 600,323 6,556,858 B1 * 4/2003 Zeman ............. ... 600,473 (76) Inventor: Rhett Drugge, 50 Glenbrook Rd., Suite 6,597,941 B2. T/2003 Fontenot et al. ............ 600/473 1C, Stamford, NH (US) 06902-2914 7,092,014 B1 8/2006 Li et al. .................. 348.218.1 (*) Notice: Subject to any disclaimer, the term of this k cited. by examiner patent is extended or adjusted under 35 Primary Examiner Daniel Robinson U.S.C. 154(b) by 802 days. (74) Attorney, Agent, or Firm—McCarter & English, LLP (21) Appl. No.: 09/625,712 (57) ABSTRACT (22) Filed: Jul. 26, 2000 Total Immersion Photography (TIP) is disclosed, preferably for the use of screening for various medical and cosmetic (51) Int. Cl. conditions. TIP, in a preferred embodiment, comprises an A6 IB 6/00 (2006.01) enclosed structure that may be sized in accordance with an (52) U.S. Cl. ....................................... 600/476; 600/477 entire person, or individual body parts. Disposed therein are (58) Field of Classification Search ................ 600/476, a plurality of imaging means which may gather a variety of 600/162,407, 477, 478,479, 480; A61 B 6/00 information, e.g., chemical, light, temperature, etc. In a See application file for complete search history. preferred embodiment, a computer and plurality of USB (56) References Cited hubs are used to remotely operate and control digital cam eras. -
Chloracne and Hyperpigmentation Caused by Exposure to Hazardous Aryl Hydrocarbon Receptor Ligands
International Journal of Environmental Research and Public Health Review Chloracne and Hyperpigmentation Caused by Exposure to Hazardous Aryl Hydrocarbon Receptor Ligands Masutaka Furue 1,2,3,* and Gaku Tsuji 1,2 1 Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; [email protected] 2 Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan 3 Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan * Correspondence: [email protected]; Tel.: +81-92-642-5581; Fax: +81-92-642-5600 Received: 21 October 2019; Accepted: 2 December 2019; Published: 3 December 2019 Abstract: Dioxins and dioxin-like compounds are environmental pollutants that are hazardous to human skin. They can be present in contaminated soil, water, and air particles (such as ambient PM2.5). Exposure to a high concentration of dioxins induces chloracne and hyperpigmentation. These chemicals exert their toxic effects by activating the aryl hydrocarbon receptor (AHR) which is abundantly expressed in skin cells, such as keratinocytes, sebocytes, and melanocytes. Ligation of AHR by dioxins induces exaggerated acceleration of epidermal terminal differentiation (keratinization) and converts sebocytes toward keratinocyte differentiation, which results in chloracne formation. AHR activation potently upregulates melanogenesis in melanocytes by upregulating the expression of melanogenic enzymes, which results in hyperpigmentation. Because AHR-mediated oxidative stress contributes to these hazardous effects, antioxidative agents may be potentially therapeutic for chloracne and hyperpigmentation. -
Dioxin Toxicity
TSDR June 1990 Case Studies in Environmental Medicine Dioxin Toxicity .S*virto*wte«it<zl ALERT. | \ J | Dioxins bioaccumulate in adipose tissue and can be found in most persons. j\J| Because dioxins cause cancer in some animals, human exposure is a concern. j \ / | Chloracne is the only overt clinical sign of dioxin exposure in humans. This monograph is one in a series of self-instructional publications designed to increase the primary care provider's knowledge of hazardous substances in the environment and to aid in the evaluation of potentially exposed patients. The Agency for Toxic Substances and Disease Registry (ATSDR) and the Centers for Disease Control (CDC) designate this continuing medical education activity for 1 credit hour in Category 1 of the Physician's Recognition Award of the American Medical Association and 0.1 continuing education units for other health professionals. See pages 17 to 19 for further information. Guest Contributor: Raymond Demers, MD, MPH Guest Editor: Eugene Perrin, MD Peer Reviewers: Charles Becker, MD; Jonathan Borak, MD; Joseph Cannella, MD; Bernard Goldstein, MD; Alan Hall, MD; Richard J. Jackson, MD, MPH; Jonathan Rodnick, MD; LAND Robert Wheater, MS; Brian Wummer, MD WA 30 ¿urnnc. C337 no. 7 U.S. DEPARTMENT OF HEALTH & HUMAN SERVICES 1990 Public Health Service Agency for Toxic Substances and Disease Registry CDC INFORMATION CENTER CENTERS FOR DISEASE CONTROL ATLANTA, GA 30333 TSDR How to use this issue... This issue begins with a composite case study that describes a realistic encounter with a patient. This description is followed by a pretest. The case study is further developed through Challenge questions at the end of each section. -
Designated for Electronic Publication Only UNITED STATES COURT OF
Designated for electronic publication only UNITED STATES COURT OF APPEALS FOR VETERANS CLAIMS No. 19-8685 ANTHONY M. REBICH, APPELLANT, V. DENIS MCDONOUGH, SECRETARY OF VETERANS AFFAIRS, APPELLEE. Before MEREDITH, Judge. MEMORANDUM DECISION Note: Pursuant to U.S. Vet. App. R. 30(a), this action may not be cited as precedent. MEREDITH, Judge: The appellant, Anthony M. Rebich, through counsel appeals a November 6, 2019, Board of Veterans' Appeals (Board) decision that granted an effective date of August 22, 2011, but no earlier, for the award of benefits for chloracne, and denied entitlement to a disability rating in excess of 30% for that condition. Record (R.) at 4-14. The Board's assignment of an effective date as early as August 22, 2011, is a favorable finding that the Court may not disturb. See Medrano v. Nicholson, 21 Vet.App. 165, 170 (2007), aff'd in part, dismissed in part sub nom. Medrano v. Shinseki, 332 F. App'x 625 (Fed. Cir. 2009); see also Bond v. Derwinski, 2 Vet.App. 376, 377 (1992) (per curiam order) ("This Court's jurisdiction is confined to the review of final Board . decisions which are adverse to a claimant."). The appellant raises no arguments with respect to the Board's denial of a disability rating in excess of 30% for chloracne. Accordingly, the Court considers that matter abandoned and will dismiss the appeal as to that matter. See Pederson v. McDonald, 27 Vet.App. 276, 285 (2015) (en banc). The Board remanded the matter of entitlement to benefits for bladder cancer, and that matter is not before the Court at this time. -
Aars Hot Topics Member Newsletter
AARS HOT TOPICS MEMBER NEWSLETTER American Acne and Rosacea Society 201 Claremont Avenue • Montclair, NJ 07042 (888) 744-DERM (3376) • [email protected] www.acneandrosacea.org Like Our YouTube Page Visit acneandrosacea.org to Become an AARS Member and TABLE OF CONTENTS Donate Now on acneandrosacea.org/donate Notable Upcoming Events Discounted Tuition Offer for AARS Members to Acne CME Virtual Event ................. 2 Our Officers New Medical Research J. Mark Jackson, MD Efficacy and safety of systemic isotretinoin treatment for moderate to severe acne .. 2 AARS President Clinical experience with adalimumab biosimilar Imraldi® in hidradenitis suppurativa 3 Clinical and demographic features of hidradenitis suppurativa .................................. 3 Andrea Zaenglein, MD Long-term analysis of adalimumab in Japanese patients ........................................... 3 AARS President-Elect Rosacea in acne vulgaris patients .............................................................................. 4 Antibiotic susceptibility of cutibacterium acnes strains ............................................... 4 Joshua Zeichner, MD Brazilian Society of Dermatology consensus on the use of oral isotretinoin .............. 5 AARS Treasurer Rationale for use of combination therapy in rosacea.................................................. 5 Bethanee Schlosser, MD Evaluation of skin problems and dermatology life quality index ................................. 6 AARS Secretary Correlation between depression, quality of life and clinical severity -
Part 7B: Effects Other Than Cancer
PART 7B: EFFECTS OTHER THAN CANCER 7.10. INTRODUCTION Human exposure to 2,3,7,8-TCDD has been associated with noncancer effects in most systems. The majority of effects have been reported among occupationally exposed groups, such as chemical production workers, pesticide users, and individuals who handled or were exposed to materials treated with 2,3,7,8-TCDD-contaminated pesticides, and among residents of communities contaminated with tainted waste oil (Missouri, USA) and industrial effluent (Seveso, Italy). These effects represent a complex network of responses ranging from changes in hepatic enzyme levels which, based on current evidence, do not appear to be related to clinical disease, to observable alterations in the character and physiology of the sebaceous gland, as in chloracne (Calvert et al., 1992; Taylor, 1979). This section of Chapter 7 describes, by system , the noncancer effects associated with exposure to 2,3,7,8-TCDD. The characterization of the effects by system provides a context within which to compare the results of the various studies. However, it is important to recognize that the observed effects are not independent events but rather may be one outcome in a series of interrelated outcomes, some of which we may be incapable of measuring with the present technology or which we currently do not recognize as an outcome of exposure to 2,3,7,8-TCDD. The information describing human effects attributed to exposure to 2,3,7,8-TCDD- contaminated materials is derived from a wide variety of sources, including clinical assessments (case reports) of exposed individuals and analytic epidemiologic studies using case-control, cross-sectional, and cohort designs. -
Federal Register/Vol. 67, No. 147/Wednesday, July 31, 2002
49590 Federal Register / Vol. 67, No. 147 / Wednesday, July 31, 2002 / Rules and Regulations (g) Redeterminations. VA will reassess DEPARTMENT OF VETERANS sources of information. We received a determination under this section AFFAIRS several other comments on the proposed whenever it receives evidence rule after it was published in the indicating that a change is warranted. 38 CFR Part 4 Federal Register, but none of the commenters suggested withdrawing the (h) Referrals. If a regional office is RIN 2900–AF00 proposed revision. In response to unclear in any case as to whether a comments, we have however, made condition is a covered birth defect, it Schedule for Rating Disabilities; the Skin further revisions to some of the criteria may refer the issue to the Director of the for the sake of clarity and more Compensation and Pension Service for AGENCY: Department of Veterans Affairs. objectivity and have added definitions determination. ACTION: Final rule. and explanatory notes under some (i) Effective dates. Except as provided conditions. These added changes are in § 3.114(a) or paragraph (i)(1) or (2) of SUMMARY: This document amends that discussed in more detail below. The this section, VA will award the portion of the Department of Veterans same commenter who suggested monetary allowance under subchapter II Affairs (VA) Schedule for Rating withdrawing the proposed revision also Disabilities that addresses the Skin. The of 38 U.S.C. chapter 18, for an made specific suggestions for changes to intended effect of this action is to individual