Anti-CSNK1E Polyclonal Antibody

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FOR RESEARCH USE ONLY! 04/21 Anti-CSNK1E Polyclonal Antibody CATALOG NO.: A2334-50 (50 µl) A2334-100 (100 µl) BACKGROUND DESCRIPTION: The casein kinase 1, epsilon (CSNK1E) is a serine/threonine protein kinase that is involved in the control of cellular processes including DNA replication and repair. CSNK1E is a central component of the circadian clock through its ability to control the phosphorylation of PERIOD proteins as well as their nuclear transport and degradation. Through modulation of PER1 and PER2 phosphorylation, CSNK1E can regulate the circadian period length. Casein Kinase 1 Epsilon; HCKIE; CKIe; CKI-Epsilon ALTERNATE NAMES: ANTIBODY TYPE: Polyclonal HOST/ISOTYPE: Rabbit / IgG IMMUNOGEN: KLH-conjugated synthetic peptide derived from human CSNK1E PURIFICATION: Immunogen affinity chromatography MOLECULAR WEIGHT: 47 kDa FORM: Liquid FORMULATION: In 0.42% potassium phosphate, 0.87% NaCl, pH 7.3, w/30% glycerol and 0.01% sodium azide SPECIES REACTIVITY: Human, Mouse, Rat STORAGE CONDITIONS: Aliquot and store at -20 °C. Avoid repeated freeze-thaw cycles APPLICATIONS: Western Blot: 1:500 to 1:1000 dilution; IHC: 1:100 to 1:200 dilution; IF: 1:100 to 1:500 dilution This information is only intended as a guide. The optimal dilutions must be determined by the user Western blot analysis of HEK293T and SKBR3 whole cell lysate samples using Anti-CSNK1E Polyclonal Antibody. IHC analysis of human lung cancer Immunofluorescence analysis of tissue samples using Anti-CSNK1E HEK293T cells using Anti-CSNK1E Polyclonal Antibody. Polyclonal Antibody. RELATED PRODUCTS: Phospho-CREB-1 (Ser133) Antibody (Cat. No. A1269) Anti-NAMPT Antibody (14A5) (Cat. No. A1301) Phospho CREB (Ser129) Antibody (Cat. No. A1222) Anti-KDM5C / Jarid1C / SMCX Antibody (2E4-E1-G8) (Cat. No. A1308) Anti-CREB1 Antibody (Cat. No. A1754) FOR RESEARCH USE ONLY! Not to be used on humans. 155 S. Milpitas Blvd., Milpitas, CA 95035 USA | T: (408)493-1800 F: (408)493-1801 | www.biovision.com | [email protected] .

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Gene Symbol Gene Description ACVR1B Activin a Receptor, Type IB
Table S1. Kinase clones included in human kinase cDNA library for yeast two-hybrid screening Gene Symbol Gene Description ACVR1B activin A receptor, type IB ADCK2 aarF domain containing kinase 2 ADCK4 aarF domain containing kinase 4 AGK multiple substrate lipid kinase;MULK AK1 adenylate kinase 1 AK3 adenylate kinase 3 like 1 AK3L1 adenylate kinase 3 ALDH18A1 aldehyde dehydrogenase 18 family, member A1;ALDH18A1 ALK anaplastic lymphoma kinase (Ki-1) ALPK1 alpha-kinase 1 ALPK2 alpha-kinase 2 AMHR2 anti-Mullerian hormone receptor, type II ARAF v-raf murine sarcoma 3611 viral oncogene homolog 1 ARSG arylsulfatase G;ARSG AURKB aurora kinase B AURKC aurora kinase C BCKDK branched chain alpha-ketoacid dehydrogenase kinase BMPR1A bone morphogenetic protein receptor, type IA BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) BRAF v-raf murine sarcoma viral oncogene homolog B1 BRD3 bromodomain containing 3 BRD4 bromodomain containing 4 BTK Bruton agammaglobulinemia tyrosine kinase BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) C9orf98 chromosome 9 open reading frame 98;C9orf98 CABC1 chaperone, ABC1 activity of bc1 complex like (S. pombe) CALM1 calmodulin 1 (phosphorylase kinase, delta) CALM2 calmodulin 2 (phosphorylase kinase, delta) CALM3 calmodulin 3 (phosphorylase kinase, delta) CAMK1 calcium/calmodulin-dependent protein kinase I CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha CAMK2B calcium/calmodulin-dependent
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bioRxiv preprint doi: https://doi.org/10.1101/2020.06.26.158600; this version posted June 27, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Altered Affective Behaviors in Casein Kinase 1 Epsilon Mutant Mice Lili Zhou1#a*, Karrie Fitzpatrick1#b, Christopher Olker1, Martha H. Vitaterna1, Fred W. Turek1* 1. Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, IL, USA. #a. Current address: Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. #b. Current address: Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA. *Correspondence to: [email protected] or [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.06.26.158600; this version posted June 27, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Abstract Affective behaviors and mental health are profoundly affected by disturbances in circadian rhythms. Casein kinase 1 epsilon (CSNK1E) is an essential component of the core circadian clock. Mice with tau point mutation or null mutation of this gene have shortened and lengthened circadian period respectively. Here we examined anxiety-like, fear, and depressive-like behaviors in both male and female mice of these two different mutants.
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bioRxiv preprint doi: https://doi.org/10.1101/463190; this version posted November 5, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. PREMONition: An algorithm for predicting the circadian clock-regulated molecular network Jasper Bosman1,4, Zheng Eelderink-Chen1,2, Emma Laing3 and Martha Merrow1,2 1Department of Molecular Chronobiology, University of Groningen, 9700CC Groningen, NL 2Institute of Medical Psychology, LMU Munich, 80336 Munich, DE 3School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK 4Present Address: Department of Bioinformatics, Hanze University of Applied Sciences Groningen, Zernikeplein 11, NL Corresponding authors: [email protected], [email protected] Running Title: Predicting a molecular circadian clock network 1 bioRxiv preprint doi: https://doi.org/10.1101/463190; this version posted November 5, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Abstract (204 words) A transcriptional feedback loop is central to clock function in animals, plants and fungi. The clock genes involved in its regulation are specific to - and highly conserved within - the kingdoms of life. However, other shared clock mechanisms, such as phosphorylation, are mediated by proteins found broadly among living organisms, performing functions in many cellular sub-systems. Use of homology to directly infer involvement/association with the clock mechanism in new, developing model systems, is therefore of limited use. Here we describe the approach PREMONition, PREdicting Molecular Networks, that uses functional relationships to predict molecular circadian clock associations.
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Suggestive Evidence for Association of the Circadian Genes PERIOD3 and ARNTL with Bipolar Disorder Caroline M
American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 141B:234–241 (2006) Suggestive Evidence for Association of the Circadian Genes PERIOD3 and ARNTL With Bipolar Disorder Caroline M. Nievergelt,1 Daniel F. Kripke,1 Thomas B. Barrett,1 Elyssa Burg,1 Ronald A. Remick,2 A. Dessa Sadovnick,3 Susan L. McElroy,4 Paul E. Keck Jr,4 Nicholas J. Schork,1 and John R. Kelsoe1,5* 1Department of Psychiatry, University of California, San Diego, La Jolla, California 2Department of Psychiatry, St. Paul’s Hospital, Vancouver, Canada 3Department of Medical Genetics, University of British Columbia, Vancouver, Canada 4Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 5Department of Psychiatry, San Diego VA Healthcare System, La Jolla, California Bipolar affective disorder (BPAD) is suspected to gene permutation tests (PG ¼ 0.025 and 0.008, res- arise in part from malfunctions of the circadian pectively). The most suggestive haplotypes in system, a system that enables adaptation to a daily PER3 showed a Bonferroni-corrected P-value of and seasonally cycling environment. Genetic var- PGC ¼ 0.07. These two genes have previously been iations altering functions of genes involved with implicated in circadian rhythm sleep disorders the input to the circadian clock, in the molecular and affective disorders. With correction for the feedback loops constituting the circadian oscilla- number of genes considered and tests conducted, tory mechanism itself, or in the regulatory output these data do not provide statistically significant systems could influence BPAD as a result. Several evidence for association. However, the trends for human circadian system genes have been identi- ARNTL and PER3 are suggestive of their involve- fied and localized recently, and a comparison with ment in bipolar disorder and warrant further linkage hotspots for BPAD has revealed some study in a larger sample.
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