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Uterine Double-Conditional Inactivation of Smad2 and Smad3 in Mice Causes Endometrial Dysregulation, Infertility, and Uterine Cancer
Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer Maya Krisemana,b, Diana Monsivaisa,c, Julio Agnoa, Ramya P. Masanda, Chad J. Creightond,e, and Martin M. Matzuka,c,f,g,h,1 aDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030; bReproductive Endocrinology and Infertility, Baylor College of Medicine/Texas Children’s Hospital Women’s Pavilion, Houston, TX 77030; cCenter for Drug Discovery, Baylor College of Medicine, Houston, TX 77030; dDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030; eDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030; fDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; gDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030; and hDepartment of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030 Contributed by Martin M. Matzuk, December 6, 2018 (sent for review April 30, 2018; reviewed by Milan K. Bagchi and Thomas E. Spencer) SMAD2 and SMAD3 are downstream proteins in the transforming in endometrial function. Notably, members of the transforming growth factor-β (TGF β) signaling pathway that translocate signals growth factor β (TGF β) family are involved in many cellular from the cell membrane to the nucleus, bind DNA, and control the processes and serve as principal regulators of numerous biological expression of target genes. While SMAD2/3 have important roles functions, including female reproduction. Previous studies have in the ovary, we do not fully understand the roles of SMAD2/3 in shown the TGF β family to have key roles in ovarian folliculo- the uterus and their implications in the reproductive system. -
Estrogenic Effect Present on Pap Smear
Estrogenic Effect Present On Pap Smear Is Claybourne hyracoid or pluralistic after baseless Nealy retrieve so beamingly? Nonharmonic and conidialmelting Maximilienafter Asclepiadean fixates her Brewster cache retrojectsharries his while demob Jose commensurately. bray some orarions neglectingly. Louie is sic An immediate and younger des when present on hpv They may ask about possible use of agents that can going the bonfire and cause may aggravate symptoms, such as soaps or perfumes. Possibly use of ovulation detection kit. Voskuil DW, Monninkhof EM, Elias SG et al. Bleeding Between Periods: Is high Cause major Alarm? The presence of abnormal cells in the cervix that may be precancerous is called cervical dysplasia. VVA in postmenopausal women, DHEA was only compared to placebo and no active comparator group was included. This separation can be initiated by a hemorrhage into the decidua basalis and cause formation of a decidual hematoma. The present and estrogens or pharmacist if no concentration should be made only studies do about des daughters have androgenic and deaths for disposal any unusual. Any recent abdominal pain in her RUQ? Pre and post menstrual spotting is characteristic. Other causes of a hypoestrogenic state include lactation, various lung cancer treatments, and use with certain medications. In some embodiments, the cell expresses ERa In some embodiments, the cell expresses ERβ. Spironolactone, an appeal time diuretic, and decreasing the testosterone dose, is either perfect antidote for fabulous hair growth, oily skin, agitation and acne. In present singly and estrogenic effect means a colposcopically directed biopsy revealed atypical nuclei or estrogenic effect present on pap smear after intravaginal. -
Review Article Ovariohysterectomy in the Bitch
Hindawi Publishing Corporation Obstetrics and Gynecology International Volume 2010, Article ID 542693, 7 pages doi:10.1155/2010/542693 Review Article Ovariohysterectomy in the Bitch Djemil Bencharif, Lamia Amirat, Annabelle Garand, and Daniel Tainturier Department of Reproductive Pathology, ONIRIS: Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Site de la Chantrerie, B.P:40706, 44307 Nantes Cedex, France Correspondence should be addressed to Djemil Bencharif, [email protected] Received 31 October 2009; Accepted 7 January 2010 Academic Editor: Liselotte Mettler Copyright © 2010 Djemil Bencharif et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ovariohysterectomy is a surgical procedure widely employed in practice by vets. It is indicated in cases of pyometra, uterine tumours, or other pathologies. This procedure should only be undertaken if the bitch is in a fit state to withstand general anaesthesia. However, the procedure is contradicated if the bitch presents a generalised condition with hypothermia, dehydration, and mydriasis. Ovariohysterectomy is generally performed via the linea alba. Per-vaginal hysterectomy can also be performed in the event of uterine prolapse, if the latter cannot be reduced or if has been traumatised to such an extent that it cannot be replaced safely. Specific and nonspecific complictions can occur as hemorrhage, adherences, urinary incontinence, return to oestrus including repeat surgery. After an ovariectomy, bitches tend to put on weight, it is therefore important to inform the owner and to reduce the daily ration by 10%. -
Review Article Ovariohysterectomy in the Bitch
Hindawi Publishing Corporation Obstetrics and Gynecology International Volume 2010, Article ID 542693, 7 pages doi:10.1155/2010/542693 Review Article Ovariohysterectomy in the Bitch Djemil Bencharif, Lamia Amirat, Annabelle Garand, and Daniel Tainturier Department of Reproductive Pathology, ONIRIS: Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering, Site de la Chantrerie, B.P:40706, 44307 Nantes Cedex, France Correspondence should be addressed to Djemil Bencharif, [email protected] Received 31 October 2009; Accepted 7 January 2010 Academic Editor: Liselotte Mettler Copyright © 2010 Djemil Bencharif et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ovariohysterectomy is a surgical procedure widely employed in practice by vets. It is indicated in cases of pyometra, uterine tumours, or other pathologies. This procedure should only be undertaken if the bitch is in a fit state to withstand general anaesthesia. However, the procedure is contradicated if the bitch presents a generalised condition with hypothermia, dehydration, and mydriasis. Ovariohysterectomy is generally performed via the linea alba. Per-vaginal hysterectomy can also be performed in the event of uterine prolapse, if the latter cannot be reduced or if has been traumatised to such an extent that it cannot be replaced safely. Specific and nonspecific complictions can occur as hemorrhage, adherences, urinary incontinence, return to oestrus including repeat surgery. After an ovariectomy, bitches tend to put on weight, it is therefore important to inform the owner and to reduce the daily ration by 10%. -
A Simultaneous Occurrence of Feline Mammary Carcinoma and Uterine Cystic Endometrial Hyperplasia in a Cat
pISSN 2466-1384 eISSN 2466-1392 大韓獸醫學會誌 (2017) 第 57 卷 第 4 號 Korean J Vet Res(2017) 57(4) : 245~248 https://doi.org/10.14405/kjvr.2017.57.4.245 <Short Communication> A simultaneous occurrence of feline mammary carcinoma and uterine cystic endometrial hyperplasia in a cat Ji-Hyun Yoo1, Okjin Kim2,* 1Technology Service Division, National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea 2Center for Animal Resource Development, Animal Disease Research Unit, Wonkwang University, Iksan 54538, Korea (Received: July 17, 2017; Revised: October 4, 2017; Accepted: October 24, 2017) Abstract: At the time of visiting, the cat was 6-year-old female Siamese cat. The mammary mass was solid and firm and measured 2×5cm2 in greatest diameter. The uterus revealed thick uterine horn and cross sectioned wall. Histopathologically, the mammary mass revealed feline mammary carcinoma. In the uterus, cystic endometrial hyperplasia was observed. Feline leukemia virus positive reaction was detected by polymerase chain reaction. As far as we know, this is the first report of the simultaneous feline mammary carcinoma and uterine endometrial cystic hyperplasia with Feline leukemia virus infection in a cat. Keywords: Feline leukemia virus, cats, feline mammary carcinoma, uterine hyperplasia Tumors in mammary glands have been reported mainly in older female cats above 10 to 12 years [15]. Cats with mam- mary tumors are usually dead less than 1 year after the diag- nosis, and the size of tumor mass is the most significant prognostic barometer [15]. Presentation of complex cystic endometrial hyperplasia- pyometra (CEH-P) is not very common in cats. -
Viable Ovarian Pregnancy: Case Report
MOJ Women’s Health Case Report Open Access Viable ovarian pregnancy: case report Abstract Volume 4 Issue 1 - 2017 Ovarian pregnancy is a rare variable of ectopic pregnancy with an incidence is 1-3% 1,2 1 of all ectopic pregnancies. It still remains a diagnostic challenge. As the ovarian Ahmed Altraigey, Wael Naeem, Omar 1 2 3 pregnancy clinical presentation is similar to that of tubal one, and an accurate Khaled, Mufareh Asiri, Abdullah Asiri, ultrasound diagnosis is someway controversial, the surgical diagnosis is frequently Mohammed Hussein2 made and confirmed by histo-pathological examination. We are presenting the data of 1Department of Obstetrics and Gynecology, Benha University, two cases of viable ovarian pregnancies presented with hemodynamic instability that Egypt required immediate laparotomies. Both cases needed unilateral salpingo-oophrectomy. 2Department of Obstetrics and Gynecology, Armed Forces These clinical scenarios stresses on the necessity of starting early antenatal care and Hospitals Southern Region, Saudi Arabia having a routine transvaginal first trimester ultrasound. Also clear evidence based 3Department of Obstetrics and Gynecology, King Khalid guideline for ovarian pregnancy management should be initiated using the best University, Saudi Arabia available data on the literature. Correspondence: Ahmed Altraigey, Department of Obstetrics Keywords: ectopic pregnancy; ovarian pregnancy; laparotomy and Gynecology, King Faisal Military City, base villa 9, Khamis Mushayt, 61961, Kingdom of Saudi Arabia - 43 Benha-Zagazig Street, Mansheyet Elnoor, Benha, 13511, Arab Republic of Egypt, Egypt, Tel +966544854232, +201060885050, Email [email protected]; ahmed.abdelfattah@fmed. bu.edu.eg Received: December 18, 2016 | Published: January 03, 2017 Introduction hemoglobin (Hb) of 10.5gm/dl. -
Med12 Gain-Of-Function Mutation Causes Leiomyomas and Genomic Instability
Med12 gain-of-function mutation causes leiomyomas and genomic instability Priya Mittal, … , Urvashi Surti, Aleksandar Rajkovic J Clin Invest. 2015;125(8):3280-3284. https://doi.org/10.1172/JCI81534. Brief Report Genetics Uterine leiomyomas are benign tumors that can cause pain, bleeding, and infertility in some women. Mediator complex subunit 12 (MED12) exon 2 variants are associated with uterine leiomyomas; however, the causality ofM ED12 variants, their genetic mode of action, and their role in genomic instability have not been established. Here, we generated a mouse model that conditionally expresses a Med12 missense variant (c.131G>A) in the uterus and demonstrated that this alteration alone promotes uterine leiomyoma formation and hyperplasia in both WT mice and animals harboring a uterine mesenchymal cell–specific Med12 deletion. Compared with WT animals, expression of Med12 c.131G>A in conditional Med12–KO mice resulted in earlier onset of leiomyoma lesions that were also greater in size. Moreover, leiomyomatous, Med12 c.131G>A variant–expressing uteri developed chromosomal rearrangements. Together, our results show that the common human leiomyoma–associated MED12 variant can cause leiomyomas in mice via a gain of function that drives genomic instability, which is frequently observed in human leiomyomas. Find the latest version: https://jci.me/81534/pdf BRIEF REPORT The Journal of Clinical Investigation Med12 gain-of-function mutation causes leiomyomas and genomic instability Priya Mittal,1 Yong-hyun Shin,2 Svetlana A. Yatsenko,2,3 Carlos A. Castro,2 Urvashi Surti,1,2,3 and Aleksandar Rajkovic1,2,3 1Department of Human Genetics, Graduate School of Public Health, 2Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, and 3Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. -
Cambridge University Press 978-1-108-42170-6 — Eponyms and Names in Obstetrics and Gynaecology, 3Rd Ed
Cambridge University Press 978-1-108-42170-6 — Eponyms and Names in Obstetrics and Gynaecology, 3rd ed. Thomas F. Baskett Index More Information Index abdominal palpation in pregnancy, American Birth Control League, 365 The Anatomy of the Human Gravid 322–3 American College of Obstetricians and Uterus (William Hunter), 198 Leopold’s manoeuvres, 238–9 Gynecologists, 191, 332 Anatomy of the Nervous System abdominal surgery American College of Surgeons, 61 (Klumpke), 222 Cherney incision, 81 American Gynecological Society, 33, Andrews, Charles James, 56 Maylard incision, 267–8 73, 109, 114, 121, 177, 195, 218, Andrews, Mason, 57 Penrose drain, 315–16 263, 297–8, 314, 357, 363, 391–2, Andrews, William, 57 Pfannenstiel incision, 318 397, 426, 450 androblastoma, 380 Smead–Jones suture, 393 American Journal of Obstetrics,22 antenatal care, 20–1 Aberdeen Maternity and Neonatal American Journal of Obstetrics and antenatal corticosteroids and neonatal Databank, 17 Gynecology, 120, 297 respiratory distress, 241–3 abortion, 17 American Medical Association, 121, Antenatal Pathology and Hygiene: The backstreet abortion, 365 210, 391 Embryo and Foetus (Ballantyne), habitual abortion in the second American registries of 20 trimester, 385–6 chorionepithelioma and rare antepartum haemorrhage, 252–3 therapeutic abortion, 50–1, 202 ovarian tumors, 298 causes, 342–4 Abrégé de L’art des accouchemens American Roentgenological anterior asynclitism, 248 (Le Boursier du Coudray), 98 Association, 67 anterior pituitary necrosis, 383–4 abruptio placentae, 100, 114, -
Contents More Information
Cambridge University Press 978-1-108-42170-6 — Eponyms and Names in Obstetrics and Gynaecology, 3rd ed. Thomas F. Baskett Table of Contents More Information Contents Image Credits xv About the Author xvii Preface xix Acknowledgements xx Aburel, Eugen Bogdan 1 Bandl, Ludwig 21 Continuous Epidural Analgesia Bandl’s Contraction Ring Alcock, Benjamin 2 Barcroft, Joseph 22 Alcock’s (Pudendal) Canal Fetal Physiology Aldridge, Albert Herman 2 Bard, Samuel 23 Aldridge Sling First American Obstetric Text Allen, Edgar and Doisy, Edward Adelbert 4 Barker, David James Purslove 24 Oestrogen Barker Hypothesis Apgar, Virginia 5 Barnes, Robert and Neville, Apgar Score William 26 Barnes–Neville Forceps Arias-Stella, Javier 7 Arias-Stella Reaction Barr, Murray Llewellyn 28 Barr Body (Sex Chromatin) Aschheim, Selmar and Zondek, Bernhard 8 Bartholin, Caspar 29 Aschheim–Zondek Pregnancy Test Bartholin’s Glands Asherman, Joseph 10 Barton, Lyman Guy 30 Asherman’s Syndrome Barton’s Forceps Aveling, James Hobson 11 Basset, Antoine 32 Aveling’s Repositor Radical Vulvectomy Ayre, James Ernest 12 Battey, Robert 33 Ayre’s Spatula Battey’s Operation Baer, Karl Ernst Ritter von 14 Baudelocque, Jean-Louis 34 Human Ovum/Germ Layer Theory Baudelocque’s Diameter Baillie, Matthew 15 Behçet, Hulusi 35 Ovarian Dermoid Cyst Behçet’s Syndrome Baird, Dugald 16 Bennewitz, Heinrich Gottleib 36 Birth Control/Perinatal Epidemiology Diabetes in Pregnancy Baldy, John Montgomery and Webster, John Bevis, Douglas Charles Aitchison 38 Clarence 18 Amniocentesis in Rhesus Baldy–Webster Uterine Ventrosuspension Isoimmunisation Ballantyne, John William 20 Bird, Geoffrey Colin 39 Vacuum Extraction Antenatal Care v © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-108-42170-6 — Eponyms and Names in Obstetrics and Gynaecology, 3rd ed. -
Dysfunctional Uterine Bleeding (DUB)
Dysfunctional Uterine Bleeding (DUB) What is Dysfunctional Uterine Bleeding (DUB) Dysfunctional uterine bleeding (DUB) is abnormal bleeding from the uterus that is not due to pregnancy or other recognizable pathology in the women’s uterus, pelvic or systemic disease. It is a functional problem of the uterus largely due to hormonal imbalance and not related to structural or anatomical problem. It is commonly present as heavy menstrual bleeding (menorrhagia). However, the doctor can only derive to a diagnosis of DUB after all other causes for abnormal and heavy menstrual bleeding in a patient have been investigated and excluded. Who gets DUB and why is it important to know Almost every woman is at risk of experience DUB in their lifetime. Dysfunctional uterine bleeding occurs most often in adolescent and in women after 40 and close to menopausal age. Studies showed that nearly 80% of heavy menstruation (i.e. menstrual blood loss >80 mls per month) is caused by DUB. Heavy menstrual bleeding may affect a woman’s health both medically and socially causing problem such as iron deficiency anaemia and social phobia or discomfort respectively. Dysfunctional uterine bleeding is the commonest cause of iron deficiency anaemia in women in the developed world and of chronic illness in developing world. It also affects productivity as almost 10 % of women absent from work due to heavy menstrual bleeding. For adolescent, heavy menstrual bleeding resulting in anaemia affects their school performance as they often feel lethargic and unable to participate in school activities too. What are other causes of abnormal menstrual bleeding? Other than DUB, the functional problem that often responsible for heavy or abnormal menstruation, there are many structural and systemic cause that need to be investigated and excluded first before DUB can be diagnosed. -
Attleboro-1929.Pdf (14.94Mb)
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Diagnostic Accuracy of Saline Hysterosonography in Detecting Endometrial Hyperplasia in Patients with Postmenopausal Bleeding
Original Article DIAGNOSTIC ACCURACY OF SALINE HYSTEROSONOGRAPHY IN DETECTING ENDOMETRIAL HYPERPLASIA IN PATIENTS WITH POSTMENOPAUSAL BLEEDING Beenish Yousufa, Hira Ambreenb, Tahira Mariamc , Abdul Raoufd , Ambreen Yaseena, Rabia Aslamb, Muhammad Ahsane aWomen Medical officer, Department of Obstetrics & Gynecology, Government General Hospital, Faisalabad. bConsultant Gynecologist DHQ Hospital, Chiniot. cWomen Medical officer THQ Hospital Chichawatni. dAssistant Professor, Department of Radiology, Faisalabad Medical University, Faisalabad. eMedical Officer, Department of Pediatrics, Government General Hospital, Faisalabad. ABSTRACT: BACKGROUND & OBJECTIVE: Saline hysterosonography is a simple and cost-effective method with high sensitivity to detect uterine abnormalities causing postmenopausal bleeding. The objective of this study was to evaluate the diagnostic accuracy of saline hysterosonography in detecting endometrial hyperplasia in women with postmenopausal bleeding by taking histopathology as a gold standard. METHODOLOGY: A hundred and twenty (120) cases were enrolled from the outpatient and inpatient department of obstetrics and gynecology. Proper history and relevant examination of the patient was done. Then preparations were made for the procedure. The patient was counseled and the technique explained to her. Then Foley catheter no 12 was passed in cervix and sonography was done while instilling normal saline through a cervical catheter and scan pictures were frozen and results were given by expert gynecologist of Allied Hospital, Faisalabad. Histopathology specimen was sent to the pathology lab. RESULTS: Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of saline hysterosonography in detecting endometrial hyperplasia was recorded as 96.15%,91,49%,75.76%,98.85%, and 92.5% respectively. CONCLUSION: Saline hysterosonography has high sensitivity to detect uterine hyperplasia. It can be used as a cost effective alternative to hysteroscopy in many units in Pakistan.