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12.Abnormal Pathologies.Pdf IAJPS 2017, 4(06), 1501-1504 Zohreh Mahmoodi ISSN 2349-7750 CODEN [USA]: IAJPBB ISSN: 2349-7750 INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES Available online at: http://www.iajps.com Research Article INVESTIGATING THE PREVALENCE OF ABNORMAL PATHOLOGIES IN EVACUATIVE CURETTAGE PRODUCTS IN AMIR-ALMOMENIN HOSPITAL IN ZABOL, 2013 TO 2016 Khadijeh Rezaie Keikhaie1and Zohreh Mahmoodi2* 1Department Obstetrics and Gynecology, Maternal and Fetal Health Research Center, Zabol University of Medical Sciences, Zabol, Iran. 2Department of Cardiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. Abstract: Diagnostic curettage, endometrial biopsy, and hysteroscopy are some diagnostic methods for patients who are hospitalized with abnormal uterine bleeding. In fact, curettage is implemented to diagnose uterine complications, treat forgotten abortions, and determine the cause of infertility. The main objective of the present study is investigating the prevalence of abnormal pathologies in evacuative curettage products in Amiralmomenin Hospital in Zabol from 2013 to 2016. The present descriptive study included 339 patients, aged more than 35 years old, who underwent diagnostic curettage because of abnormal bleeding in Amiralmomenin Hospital in Zabol from 2013 to 2016. Required data was collected using a researcher-made questionnaire and analyzed using SPSS, Version 18. Mean age of patients with cancer turned out to be 45.75±1.98, 54.4±1.33 for atrophy patients, 44.31±0.45 for miscellaneous diagnosis, and 43.45±0.95 for healthy subjects. According to the analysis of the results of sample curettage pathologies, 134 cases (39.5%) had Hyperplasia, 7 cases (2.06%) had cancer, 40 cases (11.79%) had atrophy, 107 cases (31.5%) had normal uterus, and 51 cases (15.04%) had miscellaneous complications; in case of abnormal bleeding complaints, 159 cases (46.9%) had Menorrhagia, 57 cases (16.8%) had metrorrhagia, 43 cases (13.2%) had menometrorrhagia, and 80 cases (23.1%) had postmenopausal bleeding. According to the results of the present study, abnormal uterine bleeding is the most important clinical sign of endometrial cancer; therefore, it is quite essential for women above 35 years old with uterine bleeding to undergo clinical examination. It is, also, recommended to conduct further studies on the causes of hyperplasia, endometrial cancer prevention, and the impact of hyperplasia treatment. Key Words: Abnormal Pathologies, Curettage Products, Zabol, Iran. Corresponding author: Zohreh Mahmoodi, QR code Department of Cardiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. Email: [email protected], Tel: +989120644917 Please cite this article in press as Khadijeh Rezaie Keikhaie and Zohreh Mahmoodi, Investigating the Prevalence of Abnormal Pathologies in Evacuative Curettage Products in Amir-Almomenin Hospital in Zabol, 2013 To 2016, Indo Am. J. P. Sci, 2017; 4(06). www.iajps.com Page 1 IAJPS 2017, 4(06), 1501-1504 Zohreh Mahmoodi ISSN 2349-7750 INTRODUCTION: of death [13, 14]. Cervical cancer is the most Endometrial biopsy is an outpatient procedure common women malignancy, with average age of conducted for patients requiring diagnostic curettage. 19.5 years out of each 100 thousand cases, in Difficulty in crossing the mouth of the cervix, Thailand [15]. The main objective of the present particularly in nulliparous patients and study is investigating the prevalence of abnormal postmenopausal women, can be troublesome during pathologies in evacuative curettage products in dilatation, curettage, and hysteroscopy. Possible Amiralmomenin Hospital in Zabol from 2013 to complications during dilatation, curettage, and 2016. hysteroscopy can be caused by two main reasons; first, difficulty in opening the cervix (cervical MATERIALS AND METHODS: lacerations, creating a false path, bleeding, and The present descriptive study included 339 patients, perforation of the uterus) and second difficulty in aged more than 35 years old, who underwent crossing the internal holes [1]. Diagnostic curettage, diagnostic curettage because of abnormal bleeding in endometrial biopsy, and hysteroscopy are some Amiralmomenin Hospital in Zabol from 2013 to diagnostic methods for patients who are hospitalized 2016. Required data was collected using a with abnormal uterine bleeding. From 1943 onwards, researcher-made questionnaire and the results of dilation and curettage have been the second most endometrial pathology test samples obtained at common causes of women surgery in America [2]. Amiralmomenin Hospital pathology lab was added to Curettage is implemented to diagnose uterine the checklist. Information and data regarding the age complications, treat forgotten abortions, determine of the patient, reproductive history, contraceptive the cause of infertility, ease uterine bleeding pills, history of diabetes and high blood pressure, discomfort, and control dysmenorrhea. Performing history of caner line in the family, and the results of cervical dilation is essential as a preparatory stage for endometrial pathology and diagnostic ultrasound was uterine cavity [3, 4]. The definition of abortion investigated; collected dara was analyzed using signifies intentional culmination of pregnancy prior SPSS, Version 18 [16-18]. to 20 weeks, with the embryo weighing less than 500 gr [5]. According to the findings of various FINDINGS: conducted studies, 10-20% of pregnancies result in Based on the results of the present study, the abortion, 80% of which occur in the first trimester youngest and the oldest studies subjects aged 35 and [6]. Diagnosing abnormal uterine bleeding is a 75 years. According to the analysis of the results of significant issue in genecology; given that different sample curettage pathologies, 134 cases (39.5%) had diagnosis is presented in different ages and required Hyperplasia, 7 cases (2.06%) had cancer, 40 cases treatment is conducted according to the diagnosis, (11.79%) had atrophy, 107 cases (31.5%) had normal age of the patient, and her willingness in keeping uterus, and 51 cases (15.04%) had miscellaneous pregnancy, obstetricians and gynecologists have complications; in case of abnormal bleeding constantly been searching for more precise diagnostic complaints, 159 cases (46.9%) had Menorrhagia, 57 methods [7, 8]. The most common causes of cases (16.8%) had metrorrhagia, 43 cases (13.2%) abnormal uterine bleeding (AUB) in adults include had menometrorrhagia, and 80 cases (23.1%) had anovulation, stress, pregnancy, infection, multiple postmenopausal bleeding. Minimum and maximum ovarian endocrine disorders, hypothyroidism, pregnancy rate of the subjects turned out to be 0 and hormonal changes caused by the use of contraceptive 12, with the average of 4.9±2.6. 70.8% of subjects methods, structural damages (polyps and fibroids), had become pregnancy four times and more before; and caner [9]. With the development of imaging 43 cases (12.68%), none of whom had cancer, took techniques, such as trans vaginal ultrasound which contraceptive pills. 19 cases had Hyperplasia, 21 facilitate close measuring of endometrium, this causes were normal, and 3 cases were diagnosed with noninvasive, inexpensive method has become more miscellaneous complications. 26 cases (7.6%), 9 of and more effective in distinguishing benign and whom had hyperplasia, 13 cases had atrophic malignant causes of postmenopausal bleeding [10]. endometria, and 12 normal cases, had diabetes. 67 In fact, trans vaginal ultrasound can determine subjects (19.76%), two of whom had caner, 27 had patients with low risk of endometrial diseases; it, hyperplasia, 14 cases had atrophy, 16 cases were also, can discern subjects in need of sampling, in normal, and 8 cases with miscellaneous pathological comparison to those in need of hysteroscopy, by complications, had high blood pressure. One patient showing their abnormalities in the imaging process with normal pathology was diagnosed with breast [11]. Endometrial cancer, the most common clinical cancer; but, there was no history of breast, colon, or symptom of which is, in 95% of cases, abnormal gynecological cancer in her family. Based on the uterine bleeding, is the fourth common malignant results of the ultrasound, 142 subjects (41.88%), 3 cancer in the world and the most common female with cancer, 65 with hyperplasia, 21 with atrophy, 38 genital cancer [12]. Cervical cancer, 80% of which with normal endometria, and 15 with miscellaneous occur in undeveloped countries, is the second most pathological complications, had increased common malignancy in women and the leading cause endometrial thickness. The result of ultrasound www.iajps.com Page 2 IAJPS 2017, 4(06), 1501-1504 Zohreh Mahmoodi ISSN 2349-7750 turned out to be normal in 37 cases (10.91%); results of the present study. Subjects with atrophic however, there were 1 case of caner, 14 cases of endometria and those suffering from uterine cancer hyperplasia, 1 case of atrophy, 13 normal cases, and and hyperplasia had highest mean age and number of 8 cases with miscellaneous pathological pregnancies in order. Based on Melki et al study complications in the results of diagnostic pathology (2000), entitled “Dilatation and Curettage in the tests. The mean age of patients turned out to be like Evaluation of Abnormal Uterine Bleeding: followings: 45.75±1.86 for cancer, 54.4±1.33 for Histopathologic Findings and the Cost/Benefit atrophy, 44.31±0.45 for miscellaneous diagnosis, and Relation”, pathologic findings categorized 43.45±0.95 for normal subjects. There
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