R Graphics Output

ZBTB7A ZBTB7A ZBTB7A ZBTB7A ZBTB7A ZBTB7A ZBTB7A ZBTB7A ZBTB7A ZBTB7A E2F6EGR1 EGR1 E2F6 E2F6EGR1 E2F6 EGR1 E2F6 EGR1 EGR1 E2F6 E2F6 EGR1 E2F6 EGR1 E2F6EGR1 EGR1 E2F6 E2F6EGR1 EGR1 E2F6 E2F6EGR1 E2F6 EGR1 E2F6EGR1 EGR1 E2F6 E2F6 EGR1 E2F6 EGR1 E2F6EGR1 EGR1 E2F6

ZBTB7Ainput ZBTB7Ainput ZBTB7Ainput inputZBTB7A input ZBTB7A ZBTB7Ainput ZBTB7Ainput inputZBTB7A inputZBTB7A ZBTB7Ainput MAX MAX MAX MAX MAX MAX MAX MAX MAX MAX MAXETS1 ETS1MAX MAX ETS1 MAX ETS1 MAXETS1 ETS1MAX ETS1MAX ETS1MAX ETS1MAX ETS1MAX GATA2SIN3AFOSL1input input GATA2FOSL1SIN3A GATA2FOSL1SIN3A input input GATA2SIN3AFOSL1 SIN3A GATA2FOSL1 input FOSL1GATA2SIN3Ainput GATA2SIN3AFOSL1input inputSIN3AFOSL1GATA2 inputFOSL1GATA2SIN3A input FOSL1GATA2SIN3A SIN3ATHAP1MAXELF1MAX SP1 SP1SIN3ATHAP1ELF1 MAXMAX SP1MAXMAXTHAP1SIN3AELF1 MAXMAX SIN3ASP1THAP1 ELF1 ELF1 MAXMAXSIN3A THAP1SP1 SIN3ASP1MAXMAXTHAP1ELF1 ELF1SIN3AMAXSP1THAP1 THAP1MAXSIN3ASP1 ELF1 ELF1THAP1 SP1MAXMAXSIN3A ELF1THAP1SP1SIN3AMAX YY1YY1GATA2MEF2AMYCTEAD4PMLMYC YY1YY1PMLTEAD4GATA2MEF2AMYCMYC GATA2MYCPMLTEAD4MEF2AYY1YY1 MYCTEAD4GATA2MEF2APML YY1YY1 MYCMYCPMLYY1YY1MEF2AGATA2TEAD4 PMLGATA2MEF2ATEAD4MYCYY1YY1 PMLGATA2MYCMEF2AMYCTEAD4 YY1YY1 YY1YY1 PMLMYCTEAD4MYCMEF2AGATA2 PMLTEAD4MEF2AGATA2MYCYY1YY1 PMLMEF2AGATA2TEAD4YY1YY1 MYCMYC LV1 ZBTB33TAL1ATF3JUNDFOSL1SPI1MXI1NRF1JUN SP1 SPI1SP1ZBTB33FOSL1JUNDTAL1ATF3NRF1JUNMXI1 SP1ZBTB33TAL1NRF1FOSL1ATF3MXI1JUNJUNDSPI1 NRF1MXI1ZBTB33TAL1FOSL1ATF3JUNDJUNSP1SPI1 NRF1 SPI1MXI1 JUNZBTB33FOSL1ATF3JUNDTAL1SP1 NRF1ZBTB33TAL1JUNJUNDFOSL1ATF3SP1MXI1 SPI1 SPI1TAL1ZBTB33FOSL1MXI1SP1JUNDATF3JUN NRF1 TAL1ZBTB33FOSL1MXI1JUNDSP1ATF3JUNNRF1 SPI1 NRF1 SPI1JUNATF3JUNDFOSL1TAL1ZBTB33SP1MXI1 ATF3JUNDSPI1JUNFOSL1ZBTB33SP1TAL1 MXI1NRF1 TAL1PMLMEF2ATEAD4BHLHE40ETS1BHLHE40JUNDSPI1ELF1ATF3 SP2 SP2ELF1SPI1PMLTEAD4TAL1JUNDMEF2AETS1BHLHE40BHLHE40ATF3 SP2BHLHE40TAL1PMLTEAD4MEF2AJUNDATF3SPI1ETS1ELF1 BHLHE40BHLHE40TEAD4TAL1ATF3JUNDPMLMEF2ASPI1ETS1SP2ELF1 ELF1 ATF3SPI1BHLHE40PMLETS1MEF2AJUNDTEAD4TAL1SP2 TAL1ATF3ETS1JUNDPMLTEAD4MEF2ABHLHE40BHLHE40SP2SPI1ELF1 ELF1PMLSP2TAL1SPI1MEF2ATEAD4ETS1BHLHE40JUNDATF3 ATF3ETS1BHLHE40PMLTAL1TEAD4MEF2ASP2JUNDSPI1ELF1 ELF1ATF3PMLSPI1BHLHE40TAL1JUNDTEAD4BHLHE40MEF2AETS1SP2 BHLHE40ATF3BHLHE40JUNDELF1SPI1MEF2APMLTEAD4TAL1SP2ETS1 36% of variance ZBTB33BCLAF1YY1MYCTHAP1MXI1SRFMAFK YY1 ZBTB33MAFKSRFBCLAF1THAP1MXI1MYC ZBTB33MYCBCLAF1MXI1MAFKTHAP1SRFYY1 MYCMXI1MAFKZBTB33BCLAF1SRFTHAP1YY1 MYCMXI1YY1THAP1SRFMAFKBCLAF1ZBTB33 ZBTB33BCLAF1MAFKMYCSRFMXI1YY1THAP1 BCLAF1MYCZBTB33MAFKSRFMXI1THAP1 YY1 YY1 THAP1 MAFKMYCBCLAF1ZBTB33SRFMXI1 THAP1MAFKBCLAF1SRFZBTB33MYCMXI1YY1 THAP1BCLAF1SRFYY1ZBTB33MAFK MYCMXI1 YY1BCLAF1NRF1SRFMAFKMAXMAX SP2 YY1SP2MAFKBCLAF1NRF1SRF MAX SP2MAXMAXNRF1YY1BCLAF1MAFKSRF MAXMAX NRF1MAFKBCLAF1SRFYY1 SP2 NRF1 MAXMAX SRFYY1MAFKBCLAF1SP2 NRF1BCLAF1SRFMAFKMAXSP2MAXYY1 BCLAF1SP2 MAFKMAXMAXSRF YY1 NRF1YY1 MAXMAXMAFKBCLAF1SP2SRFNRF1 NRF1 MAFKBCLAF1SRFMAXMAXSP2YY1 SRFMAFKBCLAF1YY1SP2MAXMAX NRF1 MYC RFX5SIX5 RFX5SIX5 MYC RFX5MYC SIX5 MYCRFX5SIX5 MYC RFX5SIX5 SIX5RFX5MYC MYCSIX5RFX5 SIX5MYCRFX5 SIX5RFX5MYC RFX5 SIX5MYC inputRFX5ZNF143inputZNF143 NFYA NFYB inputNFYANFYB RFX5ZNF143inputZNF143 NFYB NFYA RFX5input input ZNF143ZNF143 input RFX5inputNFYBNFYAZNF143ZNF143 NFYBRFX5inputNFYAZNF143ZNF143input ZNF143ZNF143 RFX5inputNFYBNFYAinput NFYBZNF143NFYAinputRFX5input NFYBZNF143NFYARFX5inputinput inputRFX5NFYBZNF143inputNFYAZNF143 input RFX5inputNFYANFYBZNF143ZNF143 MAFFCEBPBJUNinputUSF1 FOS NFYB NFYBCEBPBMAFFFOSinputJUN USF1NFYBFOS USF1inputCEBPBJUNMAFF USF1CEBPBMAFFinputJUNNFYBFOS USF1 inputFOSNFYBJUNCEBPBMAFF JUNMAFFinputCEBPBFOSUSF1NFYB NFYBUSF1MAFFinputFOSCEBPBJUN USF1NFYBFOSinputMAFFCEBPBJUN CEBPBinputJUNNFYBMAFFFOSUSF1 USF1 CEBPBJUNFOSMAFFinputNFYB GABPA NFYAFOS NFYAGABPAGABPAFOS NFYAFOS GABPAGABPA FOSNFYA GABPAGABPAGABPAGABPA FOSNFYA FOSNFYA GABPAGABPAGABPAGABPA NFYAFOS NFYAFOS GABPA GABPAGABPANFYAFOS GABPAGABPAFOS NFYA inputinputCEBPBNFE2 CEBPBinputinput NFE2 NFE2inputinputCEBPB NFE2CEBPBinputinput NFE2 CEBPB inputinput NFE2CEBPBinputinput inputinput NFE2CEBPB NFE2inputinputCEBPB CEBPBinputinputNFE2 NFE2CEBPB input input USF2SIX5 FOS FOS SIX5 USF2 FOS USF2 SIX5 USF2 FOS SIX5 USF2 FOSSIX5 SIX5 FOSUSF2 USF2FOSSIX5 USF2SIX5 FOS SIX5USF2FOS USF2 FOS SIX5 SIX5MAFFinputNFE2SIX5USF1 MAFF input SIX5 NFE2 USF1 USF1NFE2inputMAFF SIX5SIX5MAFFUSF1NFE2input SIX5SIX5 USF1 NFE2inputSIX5MAFF SIX5SIX5 MAFFUSF1inputNFE2 USF1inputSIX5MAFFSIX5NFE2 USF1SIX5SIX5NFE2 inputMAFF NFE2inputSIX5SIX5 MAFFUSF1 USF1 NFE2 MAFFinputSIX5SIX5 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 input input input input input input input input input input NFYBNFYB NFYBNFYB NFYBNFYB NFYBNFYB NFYBNFYB NFYBNFYB NFYBNFYB NFYBNFYB NFYBNFYB NFYBNFYB

NFYAFOS NFYAFOS NFYAFOS FOSNFYA FOSNFYA FOSNFYA NFYAFOS NFYAFOS NFYAFOS FOS NFYA FOSFOSNFYA NFYAFOSFOS FOSFOSNFYA FOSNFYAFOS FOSFOSNFYA FOSNFYAFOS NFYAFOSFOS FOSNFYAFOS NFYAFOSFOS FOSFOS NFYA

SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 LV2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP1 8% of variance SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 USF1USF1ZNF143 ZNF143 USF1USF1 USF1USF1 ZNF143 USF1USF1 ZNF143 USF1USF1 ZNF143 ZNF143 USF1 ZNF143USF1USF1 USF1USF1ZNF143 ZNF143USF1 USF1USF1 ZNF143 USF2NFE2NFE2ZNF143 ZNF143NFE2NFE2USF2 NFE2NFE2USF2 ZNF143USF2 NFE2NFE2 ZNF143 USF2NFE2NFE2 ZNF143 ZNF143 NFE2NFE2USF2 USF2ZNF143NFE2NFE2 USF2NFE2NFE2ZNF143 NFE2NFE2USF2ZNF143 NFE2USF2 ZNF143 MAFFinputUSF2SIX5SIX5inputSIX5RFX5 MAFF inputinput RFX5SIX5SIX5 USF2 RFX5USF2inputinputMAFFSIX5 SIX5SIX5MAFFUSF2inputinput RFX5SIX5SIX5SIX5 USF2 RFX5inputSIX5MAFFSIX5SIX5input SIX5SIX5RFX5MAFFinputinputUSF2 USF2inputinputMAFFSIX5RFX5 USF2SIX5SIX5SIX5inputinputRFX5MAFF inputSIX5SIX5SIX5RFX5USF2inputMAFF input USF2 RFX5MAFFinputSIX5SIX5SIX5 SIX5CEBPBinputRFX5ATF3 input inputCEBPBRFX5inputSIX5 ATF3 RFX5inputCEBPBATF3input SIX5 inputCEBPBATF3inputRFX5 SIX5 ATF3 inputRFX5SIX5CEBPBinput SIX5ATF3RFX5inputCEBPBinput RFX5SIX5inputinputATF3CEBPB SIX5ATF3RFX5inputinputCEBPB CEBPBinputATF3SIX5RFX5input input ATF3CEBPBRFX5input SIX5 CEBPBJUNinputMAXBHLHE40MAFKBHLHE40ELF1JUN CEBPBELF1MAFKJUNinputJUN BHLHE40BHLHE40MAX BHLHE40MAXMAXinputCEBPBJUNJUNMAFK ELF1 MAXMAXBHLHE40BHLHE40CEBPBMAFKJUNinputJUN ELF1 ELF1 MAXMAXBHLHE40JUNinputMAFKJUNCEBPB JUNJUNMAFKinputBHLHE40BHLHE40CEBPBMAXMAX ELF1 ELF1BHLHE40MAFKinputMAXMAXJUNCEBPBJUN BHLHE40MAXMAXinputMAFKCEBPBJUNJUNELF1 ELF1CEBPBinputJUNJUNMAFKBHLHE40BHLHE40MAXMAX BHLHE40BHLHE40CEBPBJUNJUNELF1MAFKMAXinputMAX input GABPAGABPANRF1SRFTHAP1MXI1MAFKJUNDFOSL1SPI1JUNDMXI1NRF1SPI1THAP1 input inputGABPASPI1GABPASPI1MAFKJUNDFOSL1JUNDNRF1NRF1SRFTHAP1MXI1THAP1MXI1input inputNRF1FOSL1THAP1MXI1JUNDMXI1JUNDMAFKTHAP1SPI1SRFinputSPI1 GABPAGABPA input NRF1MXI1NRF1MXI1MAFKFOSL1JUNDJUNDSPI1SPI1inputSRFTHAP1 GABPAGABPAGABPANRF1GABPANRF1 SPI1MXI1MXI1SPI1SRFinputTHAP1inputMAFKTHAP1FOSL1JUNDJUND NRF1NRF1JUNDJUNDSRFFOSL1MAFKinputMXI1MXI1inputTHAP1SPI1THAP1SPI1 GABPAGABPAGABPAGABPA SPI1SPI1MAFKinputFOSL1MXI1inputMXI1JUNDSRFTHAP1 NRF1NRF1 THAP1THAP1inputinputMAFKFOSL1MXI1MXI1JUNDSRFNRF1NRF1SPI1SPI1GABPANRF1NRF1 THAP1THAP1GABPAinputSPI1GABPASPI1MAFKinputJUNDFOSL1SRFMXI1MXI1 JUNDGABPAGABPAJUNDSPI1SRFFOSL1SPI1THAP1THAP1MAFKinputinputMXI1NRF1NRF1 MAFFSRFETS1ATF3MAXELF1FOSL1MAX EGR1EGR1 MAFFATF3SRFFOSL1ETS1ELF1EGR1MAXMAX EGR1MAXMAXFOSL1ATF3MAFFSRFELF1ETS1 MAXMAFFMAXATF3FOSL1SRFETS1EGR1EGR1 ELF1 ELF1 MAXMAX SRFETS1ATF3FOSL1MAFFEGR1EGR1 ETS1EGR1MAFFEGR1FOSL1ATF3SRFMAXMAX ELF1 ELF1ETS1MAXFOSL1MAFFSRFEGR1ATF3EGR1 ETS1MAXFOSL1MAFFSRFATF3EGR1EGR1ELF1 ELF1 EGR1EGR1ATF3FOSL1ETS1SRFMAFFMAXMAX EGR1EGR1ATF3ELF1FOSL1SRFMAFFMAXETS1 input MYCMYCMEF2ATEAD4TEAD4MEF2ASIN3ASIN3AMAXETS1ZBTB7AZBTB7AE2F6E2F6 TEAD4inputTEAD4MEF2AMEF2ASIN3ASIN3AZBTB7AMYCMYCETS1ZBTB7AMAX E2F6 E2F6ZBTB7AZBTB7AMAXMYCTEAD4MYCTEAD4MEF2ASIN3AMEF2ASIN3AinputETS1 MAXinputMYCMYCE2F6TEAD4TEAD4MEF2ASIN3AMEF2ASIN3AZBTB7AETS1ZBTB7A SIN3AMYCMYCSIN3AMAXETS1MEF2ATEAD4E2F6E2F6ZBTB7AZBTB7Ainput MEF2ATEAD4MEF2AMYCZBTB7AETS1SIN3ASIN3AinputMAX E2F6E2F6 ZBTB7AinputSIN3AE2F6MEF2ASIN3ATEAD4MEF2AETS1TEAD4MYCMAXMYC E2F6E2F6ETS1MAXSIN3ATEAD4MYCMEF2ASIN3AMEF2AZBTB7Ainput E2F6ZBTB7AZBTB7AinputTEAD4TEAD4MEF2AMEF2AETS1MAXMYCSIN3ASIN3A MEF2AMEF2AZBTB7ATEAD4ZBTB7ATEAD4SIN3AETS1inputMYCE2F6MAXMYC input BCLAF1BCLAF1ZBTB33TAL1ZBTB33PMLTAL1GATA2MYCMYCPML MAX PMLPMLZBTB33TAL1GATA2ZBTB33BCLAF1inputTAL1BCLAF1MYCMYC MAX MAXZBTB33GATA2MYCTAL1PMLTAL1PMLinputBCLAF1BCLAF1 MAXinputMYCTAL1GATA2ZBTB33TAL1PMLBCLAF1PMLBCLAF1 MYCMYCMAXPMLPMLZBTB33BCLAF1GATA2BCLAF1TAL1ZBTB33TAL1 input ZBTB33TAL1ZBTB33TAL1PMLBCLAF1PMLBCLAF1GATA2MYCinputMAX inputBCLAF1PMLTAL1TAL1GATA2MYCMYCZBTB33MAX PMLinputTAL1MAXMYCMYCTAL1BCLAF1ZBTB33GATA2BCLAF1ZBTB33 inputPMLPMLBCLAF1BCLAF1TAL1TAL1GATA2ZBTB33ZBTB33MAXMYC PMLZBTB33PMLGATA2BCLAF1BCLAF1ZBTB33TAL1TAL1MYCMYCMAXinput YY1 GATA2 YY1 GATA2 GATA2 YY1 GATA2 YY1 YY1 GATA2 GATA2YY1 GATA2 YY1 YY1 GATA2 GATA2 YY1 YY1GATA2 YY1 YY1 YY1 YY1 YY1 YY1 YY1 YY1 YY1 YY1 YY1 YY1YY1 YY1YY1 YY1YY1 YY1YY1 YY1YY1 YY1YY1 YY1YY1 YY1YY1 YY1YY1 USF1USF1 E2F6E2F6 E2F6E2F6 USF1USF1 E2F6 USF1USF1 USF1USF1 E2F6 USF1USF1 E2F6E2F6 USF1 E2F6E2F6 E2F6USF1USF1 USF1USF1E2F6E2F6 E2F6 USF1 USF1USF1 E2F6 MAX MAX MAX MAX MAX MAX MAX MAX MAX MAX USF2 MAXATF3 MAXATF3USF2 MAXUSF2ATF3 USF2MAX ATF3 ATF3MAXUSF2 ATF3 USF2MAX USF2MAXATF3 USF2ATF3MAX ATF3USF2MAX USF2ATF3 MAX USF2 BHLHE40BHLHE40MAXMAX MAXBHLHE40MAXBHLHE40USF2 BHLHE40MAXMAXUSF2 USF2BHLHE40BHLHE40MAXMAX USF2MAXMAXBHLHE40 BHLHE40BHLHE40MAXMAXUSF2 USF2MAXMAXBHLHE40 USF2 BHLHE40MAX BHLHE40USF2BHLHE40MAXMAX BHLHE40BHLHE40USF2 MAXMAX MAXMAX MAXMAX MAXMAX MAXMAX MAXMAX MAXMAX MAXMAX MAXMAX MAXMAX MAXMAX NFE2 EGR1EGR1ZBTB7A ZBTB7AEGR1EGR1NFE2 EGR1ZBTB7ANFE2 NFE2 ZBTB7AEGR1EGR1 NFE2 ZBTB7AEGR1EGR1 EGR1EGR1ZBTB7ANFE2 ZBTB7ANFE2EGR1EGR1 NFE2 ZBTB7AEGR1EGR1 ZBTB7AEGR1EGR1NFE2 EGR1EGR1NFE2 ZBTB7A NFE2 input inputNFE2 inputNFE2 NFE2 input inputNFE2 inputNFE2 inputNFE2 NFE2 input inputNFE2 NFE2 input MYCMYCETS1ZBTB7A MYCZBTB7AMYCETS1 ZBTB7AMYC ETS1 MYC ZBTB7AETS1 MYCMYCETS1 ZBTB7A ZBTB7AETS1MYC ZBTB7AMYCETS1MYC ETS1MYCMYCZBTB7A ZBTB7AETS1MYC ZBTB7AETS1MYCMYC MYCMYCETS1ELF1FOSL1SIN3A SIN3AMYCFOSL1MYCELF1ETS1 MYCFOSL1MYCSIN3AELF1ETS1 MYCMYC SIN3AFOSL1ETS1 ELF1 ELF1 SIN3AMYCMYC ETS1FOSL1 ETS1FOSL1MYCSIN3A ELF1 ELF1SIN3AMYCMYCETS1FOSL1 ETS1SIN3AMYCFOSL1 ELF1 ELF1 FOSL1ETS1MYCSIN3A ELF1FOSL1SIN3AETS1MYCMYC ZNF143MXI1THAP1SIN3A SIN3ATHAP1MXI1ZNF143 THAP1SIN3AMXI1 ZNF143 MXI1SIN3AZNF143THAP1 MXI1SIN3A THAP1 ZNF143 ZNF143 SIN3AMXI1THAP1 SIN3AZNF143MXI1THAP1 THAP1ZNF143SIN3AMXI1 THAP1 ZNF143SIN3AMXI1 THAP1SIN3AMXI1ZNF143 ZNF143BCLAF1THAP1MXI1 GATA2 GATA2BCLAF1THAP1MXI1ZNF143 GATA2BCLAF1MXI1THAP1 ZNF143 MXI1GATA2BCLAF1ZNF143THAP1 MXI1 THAP1BCLAF1GATA2ZNF143 ZNF143 BCLAF1GATA2MXI1THAP1 BCLAF1GATA2ZNF143MXI1THAP1 THAP1ZNF143GATA2BCLAF1MXI1 THAP1BCLAF1ZNF143GATA2MXI1 THAP1BCLAF1GATA2MXI1ZNF143 inputBCLAF1NRF1SRFSRFNRF1JUNMEF2A BCLAF1MEF2ASRFNRF1SRFinputJUN LV3 NRF1MEF2AinputJUNBCLAF1SRFSRF NRF1NRF1MEF2ABCLAF1inputJUNSRFSRF NRF1NRF1 SRFSRFJUNinputBCLAF1MEF2A NRF1NRF1BCLAF1JUNSRFMEF2AinputSRF BCLAF1MEF2ASRFinputSRFJUN NRF1NRF1 inputMEF2ABCLAF1SRFSRFJUNNRF1NRF1 NRF1NRF1 inputJUNBCLAF1MEF2ASRFSRF JUNSRFMEF2ASRFBCLAF1input NRF1NRF1 SIX5SIX5SIX5input MEF2AZBTB33FOSL1JUNDTAL1ATF3 ZBTB33MEF2AinputTAL1ATF3JUNDFOSL1SIX5SIX5SIX5 ZBTB33TAL1FOSL1inputMEF2AATF3JUND SIX5SIX5SIX5 inputZBTB33TAL1FOSL1ATF3MEF2AJUND SIX5SIX5SIX5 ZBTB33FOSL1ATF3MEF2ASIX5JUNDTAL1SIX5 input ZBTB33TAL1SIX5SIX5JUNDFOSL1MEF2AATF3input input TAL1MEF2AZBTB33SIX5FOSL1SIX5JUNDATF3 SIX5SIX5 inputMEF2ATAL1ZBTB33FOSL1JUNDATF3 inputSIX5SIX5SIX5ATF3JUNDMEF2AFOSL1TAL1ZBTB33 ATF3JUNDFOSL1ZBTB33MEF2ATAL1 SIX5SIX5inputSIX5 JUNSIX5ZBTB33MAFKJUNDTEAD4GATA2SP1 ZBTB33GATA2TEAD4MAFKJUNDJUNSIX5 SP1 5% of variance SP1ZBTB33GATA2TEAD4JUNDMAFKJUN SIX5 TEAD4MAFKGATA2ZBTB33JUNDJUNSIX5SP1 MAFKJUNJUNDGATA2TEAD4ZBTB33SIX5SP1 ZBTB33JUNDJUNGATA2TEAD4SIX5MAFKSP1 GATA2TEAD4ZBTB33MAFKSP1SIX5JUNDJUN SIX5MAFKTEAD4GATA2ZBTB33SP1JUNDJUN JUNMAFKSIX5TEAD4JUNDGATA2ZBTB33SP1 JUNDJUN GATA2TEAD4SP1ZBTB33MAFK SIX5 inputinputRFX5MAFKTEAD4TAL1SP1 TAL1TEAD4inputMAFKinputRFX5SP1 SP1TAL1RFX5TEAD4inputMAFK inputTEAD4MAFKTAL1inputRFX5SP1 inputRFX5MAFKTEAD4TAL1SP1 input TAL1TEAD4MAFKRFX5inputSP1input inputTAL1TEAD4MAFKSP1inputRFX5 TAL1TEAD4inputMAFKRFX5inputSP1 inputinputRFX5MAFKTAL1TEAD4SP1 MAFKRFX5SP1TEAD4TAL1inputinput FOSRFX5SP2ELF1PMLSPI1PMLYY1 YY1PMLPMLSPI1ELF1RFX5 SP2 FOS FOS SP2PMLPMLRFX5YY1 SPI1ELF1 RFX5PMLPMLFOSSPI1 YY1ELF1SP2 ELF1 SPI1PMLPMLYY1RFX5FOSSP2 PMLPMLRFX5FOSYY1SP2SPI1ELF1 ELF1SP2PMLSPI1RFX5FOS YY1 YY1 FOSPMLRFX5SP2SPI1ELF1 ELF1PMLPMLSPI1RFX5FOSSP2YY1 PMLELF1SPI1FOSPMLRFX5YY1SP2 GABPA SP2 GABPA SP2 SP2 GABPA SP2 GABPAGABPA SP2 SP2 GABPAGABPA SP2 SP2 GABPA GABPA SP2 GABPA SP2 CEBPBFOSGABPAFOSMAFF SPI1 MAFFGABPASPI1CEBPB FOSFOS FOSFOS CEBPBMAFFSPI1 GABPA CEBPBMAFFFOSFOSSPI1 GABPA GABPA SPI1 FOSFOSCEBPBMAFF MAFFFOSFOSCEBPB SPI1 GABPAGABPA SPI1MAFFFOSFOS CEBPB FOSMAFFCEBPBSPI1GABPA CEBPBSPI1GABPAMAFFFOS CEBPBGABPASPI1FOSFOSMAFF input inputCEBPBYY1YY1YY1 YY1YY1YY1 inputCEBPBinput YY1CEBPBYY1YY1inputinput inputCEBPBinput YY1YY1 YY1YY1inputinputCEBPB CEBPBinputinputYY1YY1YY1 inputinput CEBPBYY1YY1YY1 YY1YY1YY1 inputinputCEBPB CEBPBinputinput YY1YY1YY1 CEBPBYY1YY1inputinput NFYANFYBNFYA NFYANFYANFYB NFYBNFYANFYA NFYANFYBNFYA NFYBNFYANFYA NFYBNFYANFYA NFYANFYBNFYA NFYBNFYANFYA NFYANFYBNFYA NFYANFYANFYB NFYBinput input inputinput NFYB NFYB inputinput inputinput NFYB NFYB inputinput NFYBinputinput NFYBinputinput NFYBinputinput NFYBinputinput input input NFYB

MAFF MAFF MAFF MAFF MAFF MAFF MAFF MAFF MAFF MAFF SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5SIX5ZNF143 SIX5ZNF143SIX5ZNF143 SIX5ZNF143ZNF143 ZNF143ZNF143SIX5SIX5 SIX5SIX5ZNF143ZNF143 ZNF143ZNF143 SIX5SIX5 ZNF143SIX5SIX5 SIX5ZNF143 SIX5SIX5ZNF143ZNF143 SIX5ZNF143SIX5ZNF143

GABPAGABPASIX5 GABPASIX5 GABPAGABPASIX5 SIX5 GABPAGABPAGABPAGABPA SIX5 SIX5 GABPAGABPAGABPAGABPA SIX5 SIX5 GABPA GABPAGABPASIX5 GABPAGABPA SIX5 MAFF MAFF MAFF MAFF MAFF MAFF MAFF MAFF MAFF MAFF ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 inputETS1 input ETS1inputinput inputinput ETS1 inputinput ETS1 ETS1 inputinput ETS1 inputinput ETS1inputinput ETS1inputinput inputinputETS1 input input ETS1 input input SPI1ELF1 ELF1SPI1inputinput inputinputSPI1 ELF1 input input SPI1 ELF1 ELF1 SPI1 inputinput inputinput ELF1SPI1 ELF1SPI1inputinput inputinput ELF1SPI1 ELF1SPI1inputinput SPI1ELF1 inputinput SRFYY1SRFSPI1ATF3 YY1SRFSPI1SRFATF3 YY1 SPI1SRF ATF3 LV4 ATF3SPI1SRFSRF YY1 ATF3SPI1YY1SRFSRF ATF3SRFSRF YY1SPI1 SPI1SRFSRFATF3YY1 YY1 ATF3 SRFSRFSPI1 ATF3SPI1SRFSRF YY1 ATF3SRFSPI1SRFYY1 MAFFBCLAF1MAFKTHAP1MAFK ETS1 BCLAF1ETS1MAFFTHAP1MAFKMAFK MAFFMAFKMAFKBCLAF1THAP1ETS1 MAFFMAFKMAFKBCLAF1ETS1THAP1 ETS1THAP1MAFKMAFKBCLAF1MAFF BCLAF1MAFFMAFKMAFKETS1 THAP1 BCLAF1ETS1MAFKMAFKMAFFTHAP1 THAP1 ETS1MAFKMAFKMAFFBCLAF1 THAP1MAFKMAFKBCLAF1ETS1MAFF THAP1MAFKBCLAF1MAFKMAFFETS1 CEBPBCEBPBJUNBCLAF1MXI1JUNDJUND BCLAF1JUNDMXI1JUNDCEBPBCEBPBJUN CEBPBCEBPBJUNDJUNJUNDBCLAF1MXI1 5% of variance CEBPBCEBPBMXI1JUNDJUNDJUNBCLAF1 MXI1 JUNJUNDBCLAF1CEBPBJUNDCEBPB JUNDJUNDJUNBCLAF1CEBPBCEBPBMXI1 BCLAF1MXI1JUNDCEBPBCEBPBJUN BCLAF1MXI1CEBPBJUNDJUN CEBPBCEBPBJUNBCLAF1JUNDMXI1 CEBPBJUNDCEBPBJUNJUNDBCLAF1 MXI1 USF2NFE2USF2inputinputYY1MEF2ATEAD4FOSL1MXI1ATF3JUNMEF2ATHAP1SIN3A YY1MEF2ATEAD4SIN3AinputTHAP1ATF3FOSL1MXI1JUNinputUSF2NFE2USF2 YY1 TEAD4inputinputMEF2AFOSL1MEF2AATF3JUNSIN3ATHAP1MXI1NFE2USF2USF2 USF2USF2NFE2inputTEAD4MXI1inputFOSL1ATF3MEF2ASIN3AMEF2AJUN THAP1YY1 USF2USF2MXI1SIN3AYY1NFE2inputJUNTHAP1FOSL1ATF3MEF2ATEAD4 input JUNMEF2AFOSL1TEAD4MEF2AATF3inputSIN3AMXI1NFE2USF2inputUSF2YY1THAP1 inputUSF2MEF2ASIN3ATEAD4USF2MEF2AFOSL1MXI1inputNFE2THAP1ATF3JUNYY1 YY1 USF2USF2THAP1NFE2 TEAD4MEF2AinputSIN3AMEF2AFOSL1MXI1inputATF3JUN THAP1NFE2inputJUNinputUSF2ATF3TEAD4MEF2AMEF2AFOSL1SIN3AMXI1YY1 NFE2USF2USF2ATF3JUNFOSL1MEF2AMEF2ATHAP1TEAD4YY1SIN3AinputinputMXI1 USF1NFE2inputUSF1RFX5inputRFX5NRF1ZBTB33ZBTB33NRF1TEAD4YY1FOSL1SIN3A YY1YY1ZBTB33ZBTB33TEAD4inputSIN3AFOSL1NRF1inputRFX5RFX5NFE2USF1USF1 YY1RFX5YY1ZBTB33TEAD4RFX5ZBTB33inputNRF1NRF1inputFOSL1SIN3ANFE2 USF1USF1 USF1USF1NFE2inputNRF1NRF1TEAD4RFX5ZBTB33RFX5SIN3AinputFOSL1 YY1YY1 NRF1NRF1USF1USF1SIN3ANFE2YY1YY1RFX5ZBTB33RFX5inputTEAD4ZBTB33FOSL1 input NRF1NRF1ZBTB33ZBTB33TEAD4FOSL1RFX5inputNFE2SIN3AUSF1YY1inputYY1 input SIN3ATEAD4ZBTB33USF1USF1RFX5FOSL1inputRFX5NFE2YY1YY1 NRF1NRF1YY1YY1 USF1USF1NFE2RFX5inputSIN3AinputTEAD4FOSL1RFX5ZBTB33ZBTB33NRF1NRF1 NRF1NRF1 inputinputNFE2RFX5TEAD4FOSL1ZBTB33ZBTB33SIN3AUSF1YY1YY1 USF1USF1NFE2 FOSL1ZBTB33TEAD4RFX5YY1RFX5ZBTB33YY1SIN3Ainput NRF1inputNRF1 MYCMAXBHLHE40BHLHE40MYCTAL1PMLTAL1GATA2MYCMYCPML ZBTB7A GATA2MYCZBTB7ATAL1PMLTAL1PMLMYCMYCMYCBHLHE40BHLHE40MAX PMLPMLTAL1GATA2TAL1ZBTB7AMYCMYCMYCMYCBHLHE40BHLHE40MAX MAXBHLHE40BHLHE40MYCMYCMYCTAL1GATA2TAL1PMLPMLZBTB7A MYCMAXMYCMYCMYCBHLHE40PMLPMLGATA2TAL1TAL1 ZBTB7A TAL1TAL1PMLPMLGATA2MYCZBTB7ABHLHE40BHLHE40MYCMAX PMLZBTB7ATAL1TAL1GATA2MYCMYCMYCBHLHE40MAX BHLHE40MAXPMLTAL1MYCMYCTAL1GATA2ZBTB7A PMLZBTB7APMLBHLHE40TAL1BHLHE40TAL1GATA2MAXMYC BHLHE40BHLHE40PMLPMLGATA2ZBTB7ATAL1TAL1MAXMYCMYCMYCMYC MAX MAXGATA2MAXMAXinput ZBTB7AGATA2ZBTB7AMAXMAXMAXinputMAX GATA2inputZBTB7AMAXMAXMAXMAX MAXMAXMAXMAX GATA2inputZBTB7A MAXMAXMAXMAXinputGATA2ZBTB7A GATA2ZBTB7AinputMAXMAXMAX GATA2ZBTB7AMAXMAXinputMAX MAXinputMAXMAXGATA2ZBTB7A inputZBTB7AGATA2MAXMAXMAX ZBTB7AGATA2inputMAXMAXMAX SP2SP1 MAX MAX SP1 SP2 SP2SP1 MAX MAX SP1 SP2 MAX SP2SP1 SP1SP2MAX SP2MAXSP1 MAXSP2SP1 MAXSP1SP2 SP1SP2 MAX SP2 SP1 EGR1EGR1 EGR1EGR1 SP1 SP2 SP2SP1 EGR1 SP1EGR1EGR1SP2 SP2SP1EGR1EGR1 EGR1EGR1SP1SP2 SP2 SP1EGR1EGR1 SP1SP2EGR1EGR1 EGR1EGR1SP1SP2 EGR1EGR1 SP1SP2 NFYA NFYA NFYA NFYA NFYA NFYA NFYA NFYA NFYA NFYA FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS NFYAFOSFOS E2F6E2F6 E2F6E2F6 FOSNFYAFOS NFYAFOSFOS E2F6 E2F6FOSNFYAFOS FOSFOSNFYAE2F6E2F6 FOSFOSNFYAE2F6E2F6 NFYAE2F6FOSFOS NFYAFOSE2F6E2F6 E2F6NFYAFOSFOS FOSFOS NFYAE2F6 NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB NFYB GABPA GABPA GABPA GABPA GABPA GABPAGABPA GABPA GABPA GABPA GABPA ELF1 ELF1GABPA GABPA ELF1 ELF1 GABPA GABPAELF1 ELF1 GABPAGABPA ELF1 ELF1GABPA ELF1GABPA GABPAELF1 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 SP2 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 YY1YY1 YY1YY1YY1 YY1YY1YY1 YY1YY1 YY1 YY1YY1YY1 YY1YY1YY1 YY1YY1YY1 YY1YY1 YY1YY1YY1 YY1YY1 SIX5 YY1SP2 EGR1EGR1 YY1 EGR1EGR1SIX5 SP2 YY1SP2 SIX5 EGR1 EGR1SP2 YY1 SIX5 YY1 SIX5SP2 EGR1EGR1 SIX5EGR1EGR1 SP2YY1 SP2 SIX5EGR1EGR1YY1 YY1 SIX5 SP2EGR1EGR1 EGR1EGR1SIX5 SP2YY1 EGR1EGR1 YY1SP2 SIX5 SIX5 THAP1THAP1 ZBTB7A ZBTB7ATHAP1THAP1SIX5 SIX5THAP1THAP1ZBTB7A ZBTB7ATHAP1THAP1 SIX5 THAP1THAP1SIX5 ZBTB7A SIX5ZBTB7ATHAP1THAP1 ZBTB7ASIX5THAP1 THAP1SIX5THAP1 ZBTB7A THAP1THAP1ZBTB7ASIX5 THAP1ZBTB7ATHAP1 SIX5 SIX5ZNF143ETS1 ZBTB7A ZBTB7AETS1ZNF143SIX5 SIX5ZNF143ETS1ZBTB7A ZBTB7A ETS1 ZNF143SIX5 ETS1SIX5ZNF143ZBTB7A ZNF143 SIX5ETS1ZBTB7A ZBTB7AZNF143ETS1SIX5 SIX5ETS1ZNF143ZBTB7A ZBTB7ASIX5ETS1ZNF143 ZBTB7AETS1SIX5ZNF143 ZNF143SRFSRF SP1ETS1input ETS1SRFinputSRFZNF143SP1 SP1ZNF143SRF ETS1input SP1input ETS1SRFSRF ZNF143 SRFETS1inputSRF SP1ZNF143 ZNF143 SRFSRFETS1inputSP1 ZNF143ETS1SP1SRFinputSRF ZNF143inputETS1SRFSP1SRF input ZNF143ETS1SRFSRFSP1 SRFSRFSP1inputETS1 ZNF143 SIX5BCLAF1SPI1 BCLAF1SPI1SIX5 SPI1 SIX5BCLAF1 BCLAF1SPI1 SIX5 LV5 SPI1 BCLAF1SIX5 BCLAF1SIX5 SPI1 BCLAF1SPI1SIX5 SIX5BCLAF1 SPI1 SPI1SIX5BCLAF1 SPI1BCLAF1SIX5 FOSNFYBNFYABCLAF1SPI1SP1FOSL1 BCLAF1FOSL1SPI1 SP1 NFYAFOS NFYB NFYANFYB FOSSPI1SP1BCLAF1FOSL1 NFYBFOSNFYASP1FOSL1BCLAF1SPI1 SPI1 NFYBFOSBCLAF1NFYAFOSL1SP1 BCLAF1FOSL1SP1FOSNFYBNFYA SPI1 BCLAF1NFYBSPI1NFYAFOSL1SP1FOS NFYBNFYAFOSFOSL1BCLAF1SP1SPI1 SPI1BCLAF1NFYBFOSL1NFYASP1FOS FOSL1SPI1FOSBCLAF1SP1 NFYANFYB NFYANFYBinputMEF2AJUNDJUNMEF2APMLSIN3AGATA2SIN3A GATA2MEF2ASIN3APMLJUNDinputJUN NFYANFYB NFYBNFYA PMLMEF2AJUNDMEF2AinputJUNGATA2SIN3ASIN3A NFYBNFYA GATA2PMLMEF2ASIN3AinputMEF2ASIN3AJUNJUND 4% of variance SIN3ASIN3APMLJUNinputNFYBMEF2ANFYAJUNDGATA2 PMLJUNJUNDMEF2AMEF2AGATA2inputSIN3ASIN3ANFYBNFYA PMLGATA2NFYASIN3AMEF2ASIN3AMEF2ANFYBinputJUNDJUN NFYBNFYAPMLSIN3AinputMEF2ASIN3AGATA2MEF2AJUNDJUN PMLinputNFYAJUNNFYBJUNDMEF2AMEF2AGATA2SIN3ASIN3A JUNDJUNPMLMEF2AMEF2AGATA2SIN3AinputNFYBNFYA FOSFOSJUNRFX5ZBTB33JUNDZBTB33FOSL1PMLATF3 ZBTB33ZBTB33PMLATF3FOSL1JUNDJUNRFX5 FOSFOS FOSFOSPMLZBTB33RFX5JUNDZBTB33FOSL1JUNATF3 FOSFOS ZBTB33RFX5PMLFOSL1ATF3JUNDJUN PMLRFX5ZBTB33FOSFOSL1JUNATF3JUNDFOSZBTB33 ZBTB33ZBTB33JUNDPMLJUNFOSL1ATF3RFX5FOSFOS PMLZBTB33FOSL1FOSRFX5JUNDFOSATF3JUN FOSPMLRFX5ZBTB33FOSL1ZBTB33JUNDATF3JUN PMLJUNRFX5ATF3JUNDFOSL1ZBTB33ZBTB33FOS JUNDJUNATF3FOSL1FOSZBTB33PMLFOSRFX5ZBTB33 inputRFX5MAFKATF3TAL1TEAD4GATA2 GATA2TEAD4TAL1MAFKRFX5ATF3input RFX5inputTEAD4MAFKGATA2TAL1 ATF3 GATA2TEAD4TAL1RFX5inputMAFKATF3 ATF3 inputMAFKRFX5GATA2TEAD4TAL1 TAL1ATF3GATA2TEAD4RFX5MAFKinput TAL1GATA2TEAD4MAFKRFX5inputATF3 ATF3RFX5MAFKTEAD4inputTAL1GATA2 inputATF3MAFKRFX5TEAD4TAL1GATA2 ATF3 GATA2TEAD4RFX5MAFKTAL1input NRF1MAFKMXI1TEAD4TAL1MXI1NRF1 TAL1TEAD4MXI1NRF1MAFK MAFKTEAD4TAL1NRF1NRF1MXI1MXI1 TAL1NRF1TEAD4MXI1MXI1MAFK NRF1NRF1 MXI1MXI1 MAFKTEAD4TAL1 NRF1NRF1TAL1TEAD4MAFKMXI1MXI1 TAL1TEAD4MAFKMXI1MXI1 NRF1NRF1 TAL1TEAD4MAFKMXI1MXI1NRF1NRF1 NRF1NRF1 MAFKTAL1TEAD4MXI1MXI1 MAFKTEAD4TAL1 MXI1NRF1NRF1 MYCMYC E2F6E2F6 MYCMYCE2F6E2F6 MYCMYC E2F6 E2F6 MYC MYCMYC E2F6E2F6 MYC E2F6E2F6 MYCE2F6MYC E2F6E2F6MYCMYC E2F6 MYC MYCMYCE2F6 inputinput MYCMYC MAX inputinputMYCMYCMAX inputinput MYCMYC MAX MAXMYCMYCinputinput MYCMYCMAX inputinput MYCinputMAXinput inputinputMYCMYCMAX MAXinputMYCinput inputinputMYCMAX inputMAXMYCMYCinput CEBPBCEBPBMAFF MAXMAXMAX MAXMAXMAFFMAXCEBPBCEBPB CEBPBCEBPBMAFF MAXMAXMAX MAXMAXMAXCEBPBMAFF MAXMAXMAX CEBPBCEBPBMAFF MAFFCEBPBCEBPBMAXMAX MAXMAXMAFF CEBPBCEBPB MAXMAXMAFFCEBPB CEBPBCEBPBMAFFMAXMAXMAX CEBPBCEBPBMAFFMAXMAXMAX inputNFE2NFE2 BHLHE40BHLHE40 BHLHE40BHLHE40inputNFE2NFE2 input NFE2NFE2BHLHE40BHLHE40 BHLHE40NFE2NFE2input BHLHE40NFE2NFE2input BHLHE40BHLHE40NFE2inputNFE2 inputBHLHE40NFE2NFE2 NFE2NFE2BHLHE40input NFE2inputNFE2BHLHE40BHLHE40 NFE2BHLHE40BHLHE40 input input input input input input input input input input input USF1USF1MAX input MAXMAXinputUSF1USF1 input MAXUSF1USF1 MAXMAXUSF1USF1 input USF1USF1MAXMAX input USF1inputMAXMAX USF1USF1inputMAXMAX USF1USF1MAXMAXinput inputMAXMAXUSF1 input USF1USF1 MAXMAX input USF2 inputUSF2 input USF2 USF2input USF2 input inputUSF2 USF2input USF2 input inputUSF2 USF2 input USF2MAFF MAFFUSF2 MAFF USF2 USF2 MAFF USF2 MAFF MAFFUSF2 USF2MAFF USF2 MAFF USF2MAFF USF2 MAFF input input input input input input input input input input input input input input input input input input input input ZNF143 inputZBTB7AEGR1 ZBTB7AEGR1inputZNF143 input ZNF143ZBTB7AEGR1 EGR1ZBTB7A input ZNF143 input ZBTB7AZNF143EGR1 ZNF143 EGR1ZBTB7Ainput ZBTB7AZNF143inputEGR1 ZNF143inputZBTB7AEGR1 ZBTB7AEGR1inputZNF143 input EGR1 ZBTB7A ZNF143 input EGR1ZBTB7A ZBTB7AEGR1input input ZBTB7AEGR1 EGR1ZBTB7A input input ZBTB7AEGR1 EGR1ZBTB7Ainput ZBTB7AinputEGR1 inputZBTB7AEGR1 ZBTB7AEGR1input input EGR1 ZBTB7A ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 SP1 E2F6 E2F6 SP1 SP1 E2F6 E2F6SP1 E2F6 SP1 SP1 E2F6 E2F6SP1 E2F6SP1 E2F6 SP1 SP1 E2F6 CEBPB SP1 CEBPBSP1 CEBPBSP1 SP1 CEBPB CEBPB SP1 SP1CEBPB SP1 CEBPB CEBPBSP1 CEBPB SP1 CEBPBSP1 SIX5CEBPBMAFFBCLAF1ZBTB33TAL1GATA2FOSL1 E2F6 GATA2ZBTB33BCLAF1TAL1E2F6FOSL1MAFFCEBPBSIX5 CEBPBMAFFZBTB33TAL1SIX5BCLAF1GATA2FOSL1 E2F6 E2F6GATA2ZBTB33FOSL1TAL1BCLAF1CEBPBMAFF SIX5 CEBPBMAFFE2F6ZBTB33TAL1GATA2FOSL1BCLAF1SIX5 ZBTB33TAL1SIX5MAFFBCLAF1FOSL1GATA2CEBPB E2F6 BCLAF1GATA2TAL1E2F6ZBTB33FOSL1MAFFSIX5CEBPB SIX5 E2F6FOSL1TAL1GATA2BCLAF1MAFFZBTB33CEBPB CEBPBE2F6SIX5BCLAF1FOSL1GATA2MAFFTAL1ZBTB33 CEBPBFOSL1BCLAF1ZBTB33GATA2MAFFTAL1 E2F6SIX5 MAFFSIX5NFYABCLAF1SIX5SP2MEF2ATEAD4TAL1JUNDSP2TEAD4GATA2MEF2A BCLAF1GATA2MEF2ATEAD4TAL1TEAD4JUNDSIX5MAFFSIX5 SP2SP2 NFYA MAFF NFYA SP2SP2TEAD4TEAD4TAL1GATA2BCLAF1MEF2ASIX5JUNDMEF2ASIX5 NFYA SP2GATA2TAL1TEAD4TEAD4MEF2AMEF2AJUNDBCLAF1MAFFSIX5 SIX5MAFF TEAD4TEAD4TAL1GATA2MEF2AMEF2AJUNDBCLAF1NFYASIX5SIX5SP2 SP2 TAL1SIX5BCLAF1JUNDGATA2MEF2ATEAD4SIX5MEF2AMAFFSP2NFYA BCLAF1SP2SP2TAL1NFYAGATA2MEF2ATEAD4MEF2ATEAD4SIX5MAFFSIX5JUND SIX5NFYASIX5TAL1TEAD4MEF2AMEF2AGATA2BCLAF1MAFFSP2JUND SIX5NFYASIX5TEAD4BCLAF1TAL1JUNDTEAD4MEF2AMEF2AGATA2MAFFSP2SP2 JUNDMEF2AMEF2AGATA2TEAD4BCLAF1TEAD4MAFFTAL1SP2SP2NFYASIX5SIX5 SIX5FOSNFYBNFYAJUNDETS1ZBTB33FOSL1ATF3THAP1 ZBTB33THAP1ETS1ATF3FOSL1JUNDSIX5 NFYAFOS NFYB NFYBNFYAFOSJUNDZBTB33FOSL1ATF3SIX5THAP1ETS1 NFYBFOSNFYAZBTB33FOSL1THAP1ATF3JUNDETS1 SIX5 ZBTB33FOSL1ATF3FOSJUNDNFYBNFYAETS1THAP1SIX5 ZBTB33SIX5ETS1JUNDFOSL1ATF3NFYAFOSNFYBTHAP1 ZBTB33NFYBNFYAETS1FOSL1FOSSIX5JUNDTHAP1ATF3 SIX5THAP1NFYBETS1FOSNFYAZBTB33FOSL1JUNDATF3 THAP1NFYBSIX5ATF3JUNDETS1FOSL1NFYAZBTB33FOS JUNDATF3FOSL1ZBTB33FOSTHAP1NFYAETS1NFYBSIX5 input inputFOSFOSJUNRFX5inputRFX5MAFKMAFK MAFKinputMAFKJUNinputRFX5RFX5input FOSFOS inputinputFOSRFX5FOSMAFKRFX5MAFKJUNinput FOS RFX5RFX5inputMAFKJUNinputinput input inputMAFKMAFKRFX5RFX5FOSJUNinputFOS LV6 JUNMAFKRFX5MAFKinputFOSFOSinputinput inputMAFKRFX5MAFKinputinputRFX5FOSFOS JUN inputFOSRFX5inputMAFKinputMAFKRFX5JUN inputinputJUNMAFKinputRFX5MAFKFOSFOS JUNFOSFOSMAFKRFX5RFX5MAFKinputinputinput NFE2inputNFYBTHAP1SRFJUNYY1 YY1 THAP1SRFJUNinputNFE2 NFYB NFYB YY1inputSRFTHAP1JUN NFE2 NFYB YY1NFE2inputJUNTHAP1SRF NFE2 inputJUNNFYBSRFTHAP1YY1 JUNSRFinputNFYBYY1NFE2THAP1 NFYBSRFinputNFE2THAP1JUNYY1 YY1 THAP1NFE2NFYBinputSRFJUN THAP1NFE2inputJUNNFYBSRF YY1 NFE2 JUNTHAP1SRFYY1inputNFYB YY1BHLHE40ETS1input YY1 ETS1BHLHE40input YY1 ETS1inputBHLHE40 BHLHE40inputYY1ETS1 BHLHE40 inputETS1YY1 2% of variance ETS1inputBHLHE40YY1 ETS1BHLHE40input YY1 YY1 BHLHE40inputETS1 inputBHLHE40ETS1 YY1 BHLHE40YY1inputETS1 BHLHE40SRFPMLPMLYY1 YY1 PMLPMLBHLHE40SRF YY1PMLPMLSRF BHLHE40 BHLHE40PMLPMLYY1 SRF BHLHE40 PMLPMLSRF YY1 PMLSRFPMLBHLHE40YY1 PMLBHLHE40SRF YY1 YY1 BHLHE40PML SRF PMLPMLBHLHE40SRF YY1 BHLHE40SRFPMLPMLYY1 NFE2 YY1 MAX YY1MAX NFE2 YY1 NFE2MAX MAXNFE2YY1 NFE2MAX YY1 NFE2MAXYY1 MAXNFE2 YY1 YY1 NFE2MAX NFE2MAX YY1 NFE2 YY1 MAX MXI1SPI1MYCSIN3AMAX SIN3AMYCMAXMXI1SPI1 SPI1 MXI1SIN3AMYC MAX MAXMYCSIN3AMXI1SPI1 MAXMYCMXI1SIN3ASPI1 MYCSIN3AMXI1MAXSPI1 SPI1SIN3AMYCMAXMXI1 MAXMYCSIN3AMXI1SPI1 SPI1 MAXMYCSIN3AMXI1 SPI1SIN3AMYCMXI1MAX USF2USF2 MYCMXI1MYCMAX MYCMYCMAXMXI1USF2USF2 MXI1MYCMYC MAXUSF2USF2 MAXMYCMYCUSF2MXI1USF2 USF2USF2 MAXMYCMYCMXI1 MYCMYCMXI1USF2MAXUSF2 USF2MYCUSF2MYCMAXMXI1 USF2USF2 MAXMYCMYCMXI1 USF2MYCMAXMXI1 USF2USF2 MAXMYCMYCMXI1 MYCMAXATF3SPI1MAXSIN3A SIN3AMYCMAXSPI1MAXMAXATF3 SPI1 SIN3AMYC MAXATF3MAX MAXMAXMYCSIN3AATF3SPI1 MAXMAXMAXMYCATF3SIN3ASPI1 ATF3MYCSIN3AMAXMAX SPI1 SPI1SIN3AMYCMAXMAXMAXATF3 ATF3MAXMAXMAXSIN3AMYC SPI1 SPI1ATF3 MAXMYCMAXSIN3AMAX ATF3SPI1 SIN3AMAXMAXMYC USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 NRF1ELF1 ELF1NRF1 NRF1ELF1 NRF1ELF1 NRF1 ELF1 NRF1 ELF1 ELF1 NRF1 NRF1ELF1 NRF1 ELF1 ELF1 NRF1 GABPANRF1ELF1 GABPANRF1ELF1 GABPAELF1NRF1 NRF1 ELF1GABPA NRF1 ELF1GABPA NRF1 ELF1GABPAGABPA ELF1 NRF1 NRF1ELF1GABPANRF1 ELF1GABPA GABPAELF1 NRF1 GABPA GABPA GABPA GABPA GABPA GABPAGABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPAGABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA

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GABPAGABPA GABPA GABPAGABPA GABPAGABPA GABPAGABPAGABPAGABPA GABPAGABPA GABPA GABPAGABPA GABPAGABPA GABPAGABPA GABPA GABPAGABPA GABPAGABPA GABPAGABPAGABPAGABPA GABPAGABPAGABPAGABPA GABPAGABPA GABPAGABPA SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 ELF1 SPI1ELF1 ELF1SPI1 SPI1 ELF1 SPI1ELF1 SPI1 ELF1 ELF1 SPI1 SPI1ELF1 ELF1SPI1 ELF1SPI1 ELF1SPI1 JUNNRF1 EGR1EGR1 EGR1EGR1NRF1JUN JUNNRF1 EGR1 EGR1NRF1JUN NRF1JUN EGR1EGR1 NRF1 JUN EGR1EGR1 NRF1EGR1JUNEGR1 EGR1EGR1JUN NRF1 NRF1 JUNEGR1EGR1 EGR1EGR1JUN NRF1 CEBPB NRF1 NRF1CEBPB CEBPB NRF1 NRF1CEBPB CEBPBNRF1 NRF1 CEBPB NRF1 CEBPB CEBPB NRF1 NRF1 CEBPB CEBPB NRF1 CEBPBZBTB33JUNDJUNDATF3JUNSP1 ZBTB33ATF3JUNDJUNDCEBPBJUN SP1 CEBPBZBTB33SP1JUNDJUNDATF3JUN SP1ZBTB33ATF3CEBPBJUNJUNDJUND CEBPBZBTB33ATF3JUNDJUNDJUNSP1 JUNATF3JUNDCEBPBZBTB33JUNDSP1 ZBTB33JUNDJUNJUNDATF3SP1CEBPB ZBTB33SP1JUNDATF3JUNCEBPB CEBPBJUNATF3JUNDZBTB33SP1 JUNDCEBPBATF3JUNDJUNSP1ZBTB33 inputBCLAF1BCLAF1SP2SRFMXI1SRFZBTB33FOSL1MXI1SP2SP1 ZBTB7AZBTB7ABCLAF1ZBTB33BCLAF1ZBTB7AZBTB7AinputFOSL1MXI1SRFSRF SP1SP2SP2 SP2SP2inputSP1ZBTB33BCLAF1FOSL1SRFBCLAF1MXI1MXI1ZBTB7AZBTB7A SP1ZBTB7ASP2ZBTB7AZBTB33FOSL1MXI1BCLAF1inputMXI1BCLAF1SRFSRF inputMXI1MXI1ZBTB33FOSL1BCLAF1BCLAF1SRFZBTB7ASP1SRFZBTB7ASP2 SP2 MXI1MXI1SRFSRFZBTB33FOSL1BCLAF1BCLAF1SP2SP1ZBTB7AZBTB7Ainput ZBTB33BCLAF1SRFBCLAF1FOSL1ZBTB7ASRFSP1MXI1MXI1inputSP2 BCLAF1SP2ZBTB7ASP2inputZBTB33FOSL1SP1SRFMXI1MXI1SRF ZBTB7AZBTB7AinputBCLAF1BCLAF1FOSL1SRFZBTB33SRFSP1SP2MXI1MXI1SP2 SRFFOSL1ZBTB33ZBTB7ABCLAF1SRFBCLAF1ZBTB7ASP1SP2inputSP2MXI1 MAFF MAFFRFX5MAFKMEF2ATEAD4TEAD4GATA2MEF2ASIN3AGATA2FOSL1 GATA2GATA2MEF2ATEAD4TEAD4SIN3AFOSL1MAFFMAFKMAFFRFX5 MAFF MAFFMAFKTEAD4TEAD4RFX5GATA2MEF2AMEF2AGATA2SIN3AFOSL1 GATA2GATA2TEAD4FOSL1RFX5TEAD4MEF2AMEF2ASIN3AMAFKMAFF MAFF MAFF MAFFTEAD4MAFKTEAD4GATA2RFX5MEF2AGATA2SIN3AMEF2AFOSL1 SIN3ARFX5MAFKMEF2ATEAD4GATA2MAFFGATA2FOSL1MAFF MAFFGATA2MEF2ATEAD4FOSL1MEF2AMAFKGATA2RFX5SIN3AMAFF GATA2GATA2MEF2ASIN3ATEAD4MEF2ATEAD4FOSL1MAFKMAFFMAFFRFX5 RFX5MAFKTEAD4TEAD4FOSL1MEF2AMEF2AGATA2MAFFGATA2MAFFSIN3A FOSL1MEF2AMEF2AGATA2MAFKTEAD4RFX5TEAD4MAFFGATA2MAFFSIN3A inputinputinputinputMYCMYCMAFKTAL1MYCSIN3A inputTAL1SIN3AMYCMYCMYCMAFKinputinputinput input inputMAFKinputTAL1inputSIN3AMYCMYCMYC MYCMYCTAL1MYCSIN3AinputinputMAFKinput input MYCinputMYCMYCMAFKinputTAL1SIN3Ainput SIN3AMYCMYCMYC inputMAFKinputTAL1 input input TAL1MYCMAFKinputinputMYCSIN3Ainputinput input TAL1SIN3AMYCMYCMAFKinputinputinput inputinputinputMAFKinputTAL1MYCSIN3A input MAFKSIN3ATAL1inputinputMYCMYCMYCinput input RFX5BHLHE40BHLHE40TAL1MYCMAXMAXinputMAXETS1MAXinput E2F6E2F6 MYCTAL1E2F6MAXMAXE2F6ETS1BHLHE40MAXBHLHE40MAXinputRFX5inputinput inputinputRFX5TAL1 ETS1MYCinputBHLHE40BHLHE40MAXMAXMAXMAXE2F6 E2F6BHLHE40MAXMAXMAXMAXinputMYCTAL1RFX5ETS1inputinput inputBHLHE40BHLHE40inputMAXMAXMAXE2F6MYCTAL1RFX5 inputETS1 MAXMAXMYCMAXMAXBHLHE40ETS1inputRFX5inputTAL1E2F6E2F6input TAL1RFX5BHLHE40ETS1inputBHLHE40MYCinputMAXinputMAXMAX E2F6E2F6 TAL1MYCE2F6ETS1MAXinputMAXBHLHE40RFX5inputinput E2F6inputinputRFX5BHLHE40TAL1inputBHLHE40ETS1MAXMAXMYCMAXMAX input BHLHE40BHLHE40RFX5TAL1inputETS1MAXinputMYCE2F6MAXMAX FOSFOSZNF143FOSNFYAMAXPMLPML PMLPMLMAXZNF143ZNF143 NFYAFOSFOSFOS NFYAFOSFOSFOSPMLPMLZNF143ZNF143 MAX FOSFOSNFYAMAXPMLPML ZNF143ZNF143 MAX FOSPMLFOSNFYAPMLFOSZNF143ZNF143 MAX PMLPMLFOSFOSFOSNFYAZNF143ZNF143 ZNF143ZNF143 PMLPMLFOSFOSNFYAFOSMAX PMLZNF143NFYAFOSFOSMAXFOS PMLPMLZNF143NFYAZNF143FOSFOSMAX PMLFOSFOSPMLFOS MAXNFYAZNF143ZNF143 input NFYASIX5MAXETS1 ETS1inputMAXSIX5 NFYA NFYAinput SIX5 ETS1 MAX NFYA MAX inputETS1SIX5 inputMAX NFYASIX5ETS1 MAX inputETS1NFYASIX5 ETS1SIX5 inputMAXNFYA NFYAETS1inputMAXSIX5 LV9 NFYASIX5inputETS1MAX inputMAXETS1NFYASIX5 NFE2NFYBNFYB ATF3 ATF3NFE2 NFYBNFYB NFYBNFYB NFE2ATF3 NFYBNFYB NFE2ATF3 NFE2 ATF3NFYBNFYB ATF3NFE2NFYBNFYB ATF3NFYBNFE2NFYB NFYBNFYBNFE2ATF3 ATF3NFYBNFE2NFYB NFE2ATF3 NFYBNFYB NFE2USF1 THAP1 THAP1NFE2USF1 THAP1NFE2 USF1 THAP1USF1NFE2 USF1NFE2 THAP1 USF1 NFE2THAP1 USF1NFE2THAP1 USF1NFE2THAP1 3% of variance THAP1NFE2 USF1 USF1NFE2 THAP1 SIX5USF1SIX5SIX5 THAP1 THAP1SIX5SIX5SIX5USF1 SIX5THAP1 USF1 USF1THAP1 SIX5SIX5SIX5 USF1 THAP1SIX5SIX5SIX5 USF1 THAP1SIX5SIX5 SIX5SIX5 USF1THAP1 USF1SIX5SIX5THAP1 THAP1SIX5SIX5SIX5 USF1 USF1 THAP1 SIX5SIX5SIX5 USF2USF2 USF2USF2 USF2USF2 USF2USF2 USF2USF2 USF2USF2 USF2USF2 USF2USF2 USF2 USF2USF2

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NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 ZNF143NRF1 NRF1ZNF143ZNF143 NRF1ZNF143ZNF143 NRF1 ZNF143ZNF143 NRF1 ZNF143ZNF143 NRF1 ZNF143ZNF143 ZNF143ZNF143 NRF1 ZNF143 NRF1 ZNF143 NRF1 NRF1 ZNF143ZNF143 SIX5SIX5input NRF1 inputNRF1SIX5SIX5 inputSIX5NRF1 NRF1input SIX5SIX5 inputNRF1 SIX5SIX5 NRF1 SIX5SIX5 input NRF1SIX5SIX5 input input SIX5SIX5 NRF1 SIX5 inputNRF1 NRF1 inputSIX5SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 NFYBMYCMXI1MYCMXI1 MAXMAX E2F6E2F6 E2F6MAXMAXE2F6MYCMYCMXI1 NFYB NFYB MXI1MXI1MYCMYC MAXMAXE2F6NFYBE2F6MAXMAXMYCMYCMXI1MXI1 MAXMYCMYCE2F6MXI1MXI1NFYB MYCMYCMXI1MXI1MAXMAXNFYBE2F6E2F6 MYCNFYBMXI1MXI1MAX E2F6E2F6 NFYBE2F6MYCMAXMYCMXI1MXI1 NFYBE2F6E2F6MAXMYCMXI1MXI1 E2F6NFYBMAXMAXMYCMXI1MXI1 NFYANFYBSIX5ETS1MYCMYC MYCMYCETS1SIX5 NFYANFYB NFYBNFYA SIX5 ETS1MYCMYC NFYBNFYA MYC ETS1SIX5 MYCNFYBNFYASIX5ETS1 MYCMYC ETS1NFYBNFYASIX5 ETS1SIX5MYCNFYBNFYA NFYAMYCMYCNFYBETS1SIX5 NFYBNFYASIX5ETS1MYCMYC NFYASIX5NFYBETS1MYC input NFYAMAX MAXinput NFYA NFYAinput MAX NFYAMAX input MAXinput NFYA MAX inputNFYA NFYAinputMAX NFYAinputMAX NFYAMAXinput inputNFYAMAX input inputinputinputMAX MAXMAXETS1 inputETS1MAXMAXinputinputMAXinput inputinputinputinputETS1 MAXMAXMAX MAXMAXMAXinputinputETS1input inputMAXMAXinputMAXinputinputETS1 MAXMAX ETS1inputinputinput input inputETS1inputinputMAXMAXinputMAX inputETS1MAXinputinputMAXinput inputMAXETS1MAXinputinputinput inputinputinputinputETS1MAXMAXMAX SP2SIN3ASIN3Ainput SIN3Ainput SP2 SP2 SIN3ASIN3Ainput SP2inputSIN3ASIN3A SIN3ASIN3AinputSP2 SIN3ASIN3AinputSP2 inputSIN3ASIN3ASP2 SP2SIN3ASIN3Ainput inputSIN3ASIN3ASP2 input SIN3ASP2SIN3A MAFF MAFFSP2ZBTB33YY1MAFKTEAD4TAL1TAL1GATA2 YY1GATA2ZBTB33TAL1TAL1TEAD4MAFFMAFKMAFF SP2 MAFF YY1MAFFSP2TEAD4ZBTB33MAFKTAL1TAL1GATA2 SP2GATA2ZBTB33TAL1TAL1TEAD4YY1MAFKMAFF MAFF MAFF MAFFTEAD4TAL1MAFKZBTB33TAL1GATA2 YY1 SP2 YY1MAFKTEAD4TAL1ZBTB33MAFFSP2GATA2MAFFTAL1 TAL1ZBTB33TAL1MAFFTEAD4GATA2MAFKMAFFSP2YY1 SP2GATA2TAL1TAL1TEAD4ZBTB33MAFKMAFFMAFF YY1 YY1 MAFKTAL1TEAD4TAL1GATA2MAFFMAFFZBTB33SP2 MAFKTAL1TEAD4GATA2MAFFTAL1ZBTB33MAFFSP2YY1 RFX5BCLAF1RFX5BCLAF1TEAD4YY1THAP1ZBTB7A YY1BCLAF1BCLAF1ZBTB7ATEAD4THAP1RFX5RFX5 RFX5YY1TEAD4RFX5BCLAF1BCLAF1THAP1ZBTB7A ZBTB7ATEAD4RFX5RFX5YY1THAP1BCLAF1BCLAF1 TEAD4RFX5RFX5BCLAF1BCLAF1ZBTB7ATHAP1YY1 YY1RFX5RFX5THAP1BCLAF1TEAD4BCLAF1ZBTB7A BCLAF1BCLAF1TEAD4RFX5ZBTB7AYY1THAP1 BCLAF1ZBTB7ATEAD4RFX5RFX5THAP1YY1 YY1 THAP1RFX5TEAD4BCLAF1RFX5ZBTB7ABCLAF1 THAP1ZBTB7ARFX5BCLAF1TEAD4BCLAF1YY1 MAFKMEF2AYY1SRFZBTB33GATA2SP1YY1SP1 ZBTB7AYY1ZBTB33ZBTB7AYY1GATA2MEF2ASRFMAFK SP1SP1 YY1YY1MAFKSP1GATA2SP1ZBTB33MEF2ASRF ZBTB7A SP1ZBTB7ASP1ZBTB33GATA2YY1MEF2AMAFKSRFYY1 MAFKGATA2ZBTB33MEF2ASP1SRFSP1ZBTB7AYY1 YY1YY1SRFZBTB33MAFKMEF2AGATA2SP1SP1ZBTB7A ZBTB33GATA2MEF2AMAFKZBTB7ASRFSP1SP1YY1YY1 ZBTB7AGATA2MEF2AZBTB33MAFKSP1SRFSP1 YY1YY1 YY1YY1 MEF2AMAFKZBTB33ZBTB7AGATA2SRFSP1SP1 ZBTB7AMAFKMEF2ASRFGATA2ZBTB33SP1SP1YY1YY1 FOS THAP1PMLMEF2AFOSL1 MEF2APMLFOSL1THAP1 FOS FOSPMLMEF2ATHAP1FOSL1 FOS FOSL1PMLMEF2ATHAP1 FOSPMLMEF2AFOSL1THAP1 PMLTHAP1MEF2AFOSFOSL1 PMLMEF2AFOSL1FOS THAP1 PMLMEF2AFOSL1FOSTHAP1 THAP1FOSPMLFOSL1MEF2A THAP1PMLFOSL1MEF2AFOS FOSFOS ELF1FOSL1SPI1ELF1 ELF1FOSL1SPI1ELF1 FOSFOS FOSFOSELF1SPI1FOSL1ELF1 FOS FOSL1SPI1ELF1ELF1 FOSL1FOSFOSSPI1 ELF1 ELF1 ELF1ELF1 SPI1 FOSFOSFOSL1 FOSL1FOSFOS SPI1ELF1ELF1 ELF1ELF1SPI1FOSL1FOSFOS FOSFOSL1SPI1ELF1ELF1 ELF1ELF1SPI1FOSL1FOSFOS LV11 CEBPBGABPAGABPACEBPBSRFBHLHE40JUNDJUNSPI1PML PMLBHLHE40JUNDGABPASPI1CEBPBSRFCEBPBJUN CEBPBCEBPBGABPASPI1GABPAPMLJUNDSRFJUN BHLHE40 BHLHE40PMLCEBPBJUNJUNDSRFSPI1 GABPAGABPA BHLHE40CEBPBCEBPB JUNDJUNPMLSPI1SRF GABPAGABPAGABPAGABPA SPI1BHLHE40PMLSRFJUNCEBPBJUNDCEBPB PMLJUNJUNDSRFBHLHE40CEBPBCEBPB SPI1 GABPAGABPAGABPAGABPA PMLSPI1BHLHE40JUNDSRFJUNCEBPBCEBPB BHLHE40PML CEBPBJUNDSRFJUN SPI1GABPA CEBPBCEBPBGABPAPMLSPI1GABPAJUNBHLHE40JUNDSRF USF2 JUNBHLHE40JUNDATF3 ATF3BHLHE40JUNDJUNUSF2 JUNDJUNATF3 BHLHE40USF2 BHLHE40ATF3USF2JUNDJUN USF2BHLHE40ATF3JUNDJUN USF2BHLHE40JUNATF3JUND JUNDJUNATF3BHLHE40USF2 USF2BHLHE40JUNDATF3JUN USF2 BHLHE40JUNDATF3JUN JUNUSF2ATF3JUNDBHLHE40 2% of variance USF2 ATF3 ATF3USF2 USF2ATF3 USF2ATF3 USF2 ATF3 ATF3USF2 ATF3 USF2 USF2 ATF3 USF2ATF3 ATF3USF2 NFE2 NFE2 NFE2 NFE2 NFE2 NFE2 NFE2 NFE2 NFE2 NFE2 NFE2 EGR1EGR1 EGR1EGR1NFE2 NFE2EGR1 EGR1NFE2 NFE2 EGR1EGR1 NFE2 EGR1EGR1 EGR1EGR1NFE2 NFE2EGR1EGR1 NFE2 EGR1EGR1 EGR1EGR1NFE2 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1input inputUSF1 input USF1 USF1 input USF1input USF1 input USF1input USF1input USF1 input input USF1

input input input input input input input input input input