Posted on Authorea 2 Jun 2021 | The copyright holder is the author/funder. All rights reserved. No reuse without permission. | https://doi.org/10.22541/au.162266026.60810954/v1 | This a preprint and has not been peer reviewed. Data may be preliminary. oa otcseodijcinadGop2rciigutaon-uddachlnuoyi oteentrapment the to neurolysis alcohol ultrasound-guided receiving ultrasound-guided LFCN. 1 receiving Group the du- the 2 of with a Group with groups, site and 2 paresthetica into marelgia injection divided of corticosteroid were diagnosis patients ultrasound-guided local a The with of patients months. 26 [?]10 results of of ration study the clinical retrospective compare a performed paresthetica. We and meralgia outcomes of treatment the the evaluate in Methods to neurolysis (LFCN). alcohol was nerve ultrasound-guided cutaneous study and femoral injection lateral this the corticosteroid of of mononeuropathy purpose sensory rare The very a is paresthetica Meralgia Objectives STUDY COHORT RETROSPECTIVE A Abstract PERIOD: FOLLOW-UP 28-MONTH DUR- PARESTHETICA A MERALGIA AND ING OF TREATMENT INJECTION THE IN CORTICOSTEROID NEUROLYSIS ALCOHOL ULTRASOUND-GUIDED OF At in EFFECTIVENESS improvement decreased effect. months. methods and curative treatment relief long-term 28.4 both pain and was are injection, satisfaction full 2 corticosteroid neurolysis patients’ declared Group in alcohol the 2 higher and improved and Group are months and injection rates in pain 28.7 corticosteroid recurrence patients the was the 10 persisted years Although 1 and has 42.2 1 methods. Group was paresthetica effective Group 1 of meralgia both Group in Once period in patients follow-up Conclusion patients 9 ultrasound- mean the sensitivity. period of receiving The cutaneous follow-up age 2 the mean years. Group of The 40.8 end and Results was the LFCN. injection 2 divided the corticosteroid were Group of patients local site in The retrospective ultrasound-guided entrapment and months. a the receiving [?]10 to performed of 1 neurolysis duration We Group a alcohol injection Methods the with guided corticosteroid paresthetica with marelgia ultrasound-guided paresthetica. groups, of of meralgia diagnosis 2 results a of into the with treatment patients compare 26 the and of study outcomes in clinical the neurolysis evaluate (LFCN). alcohol nerve to cutaneous ultrasound-guided was femoral lateral study and the this of mononeuropathy of sensory purpose rare very The a is paresthetica Meralgia Objectives Abstract Abstract 2021 2, June 2 1 Yapıcı Ozge STUDY COHORT RETROSPECTIVE A PERIOD: FOLLOW-UP 28-MONTH A DURING MERALGIA PARESTHETICA OF TREATMENT THE IN NEUROLYSIS ALCOHOL AND INJECTION CORTICOSTEROID ULTRASOUND-GUIDED OF EFFECTIVENESS ¨ iir ndl rvt Hospital Private Anadolu Medicine Silivri of School University Marmara 1 n Meri¸c U˘gurlarand 2 1 Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. vlae codn oteicuinadecuinciei Tbe1ad2.Alteptet nbt groups both in patients the were All groups both 2). in and examination cases 1 sensory All (Table the criteria examination. in exclusion motor symptoms. patients and normal unilateral all with inclusion had had of LFCN patients the and loss the stairs, of to sensory climbing All according distribution clear walking, LFCN. evaluated a as the of such was distribution in activities There the patients thigh pain. in the anterolateral of the the aggravated anamnesis the over extension to hip pain According severe examination, loss. disquieting sensory physical some history, had clinical patients (EMG). electromyography by in the findings established all examination were needle 10 muscle < groups thigh potential normal both amplitude and nerve in cutaneous patients (lateral the findings electromyographic all of STROBE diagnosis the follow-up The to clinical according Board. and designed Review diagnosis was Institutional study Clinical the The by 2.2 approved LFCN. ultrasound-guided and the the receiving studies with of a observational groups, 2 site with 2 for Group entrapment into paresthetica checklist and divided the marelgia were injection to patients of corticosteroid neurolysis The diagnosis local alcohol 2017. a ultrasound-guided April with receiving and patients 2012 1 August 26 Group from of months [?]10 study of clinical duration retrospective a performed We participants and desing treatment two Study these ultrasound-guided 2.1 comparing of literature METHODS English results AND the PATIENTS the in paresthetica. study 2. compare meralgia first paresthetica. of the and meralgia treatment is of outcomes the this treatment in knowledge, the the modalities our evaluate in of neurolysis best to the alcohol was To ultrasound-guided study and injection this corticosteroid of purpose required. radiofrequency The be pulsed may neurolysis, decompression alcohol methods. surgical injections, treatment even corticosteroid patients. conservative or local the treatment by conservative by relief from described pain benefit typically is get of thigh patients distribution anterolateral Generally the the in in “meros” loss thigh words anterolateral hair Greek the local the even in anesthesia from or comes LFCN. dysesthesia that the with pain. meralgia results for term paresthetica “algos” the meralgia and emphasizing thigh article an for published LFCN. Roth the later cutaneous of femoral 1885. entrapment lateral in the an of Hager from mononeuropathy sensory resulting rare (LFCN) very but nerve well-known a is paresthetica Meralgia methods treatment both INTRODUCTION effect. injection, curative corticosteroid long-term and effective in satisfaction words: both higher patients’ Key are the are improved neurolysis rates and alcohol pain recurrence and the period the injection decreased follow-up cutaneous Although corticosteroid in the persisted improvement of has methods. and end paresthetica relief the meralgia pain At Once full declared months. 2 follow-up 28.4 mean Group The was in Conclusion years. 2 patients 40.8 10 Group was 2 and and Group 1 months in sensitivity. Group and 28.7 years in was 42.2 patients was 1 9 1 Group Group in of patients period the of age mean The Results 3 h itigpi,brig odes ubes igig uceahns,fakaetei or anesthesia frank achiness, muscle tingling, numbness, coldness, burning, pain, ligtning The eagaprshtc;nreetamn;utaon;achlnuoyi;corticosteroid. neurolysis; alcohol ultrasound; entrapment; nerve paresthetica; Meralgia 3 n19,Brhrtrpre oeetnierpr bu hsnuoah n w weeks two and neuropathy this about report extensive more reported Bernhardt 1895, In 3 hscniini lokona BrhrtRt syndrome”. “Bernhardt-Roth as known also is condition This 1,5-7 2 1,2 eagaprshtc a rtdsrbdby described first was paresthetica Meralgia 3 oee,ptet h ontget not do who patients However, μ ,latency V, 8,9 1 npyia examination physical In > . milliseconds, 3.5 4 Classically Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. ieo h lrsudtasue a lgtyage nacua ieto.Acrigt alac et Tagliafico to ligament. According inguinal the direction. to caudal parallel a was medial in transducer the angled the position, extended slightly this position transducer in was ultrasound this was transducer the transducer at of ultrasound ultrasound transducer side al., the ultrasound the medial When the the of plane. of Then transducer transverse side side ultrasound spine. anatomic lateral a iliac an The by position, superior in visualized supine shadowing. anterior medially was in the acoustic and patient on posterior landmark, the placed with a With was structure as radiologist. hypoechoic palpated same was a the spine as by sudies. iliac performed previous superior were the anterior patients’ the from the adapted of was injections approach and USG technical the described of The assessment of The duration the findings. technique paresthetica, electrodiagnostic Ultrasound marelgia test. the 2.3 chi-square of and again. by etiology patients, injection done same the the was the of to get analysis weight were they according statistical they do excess analyzed whether pain, No the was patients same symptoms, the the survey feel asked period. the this they we post-injection if and of and patients the results injection all in the The for of survey days outcome simple the 3 a with drew-up for satisfied we pain follow-up patients. last relieve the the to to In advised daily the was times of limitation 3 examinations weight-bearing described tablets or USG as activity paracetamol radiologist affected All same mg the the injections. 500 of a between by the take LCFN al. days with performed after the were et 30 guidance and procedures Tagliafico of of (USG) injection by before visualization interval and ultrasonography by comparison LFCN an real-time performed for symptomatic with was patients’ thigh using evaluation month nonaffected performed USG each and were The after thigh once injections and transducer. injections before the array 3 numbness, All linear of received degree groups from sessions. The ranging both daily the pain. score, during in severe (VAS) and recorded. indicating patients scale rest was 10 The in analog severe) at and summarized visual and hours pain are a moderate; 24 no subjects cases slight; using last indicating the female (none; the recorded 0 of 4 injections, during was with data and injections, LCFN 10, demographic male were after The to of 11 and 15 0 distribution included 2. before Group population the patients, pain, in study at 26 of female The activities severity 1 the 2. The and Group Of male 3. the 10 Table treatment, to and conservative amitriptyline. 11 1 other and gabapentin, any Group 1 using in pregabaline, Group avoid therapy, the to advised to and physical were assigned events, study NSAIDs, adverse the as findings, to evaluation such allocated were EMG who analgesics, patients of The self-assessments use patients’ level, the function included and and data. groups complication activity level, both pain, in creatinine data thigh nitrogen, collected of post-treatment urea and blood pre-treatment The C-reactive time, rate, thromboplastin sedimentation lab- erythrocyte partial analysis. and counts, level time, examination, platelet electrolyte physical prothrombin and history, cell level, complete blood a protein complete included including groups tests, injections. both oratory the complications, in before possible benefit assessments as All form pre-treatment experience well consent injection. The as not informed for injections did an indicated the were of signed who objectives have period patients and follow-up they 6-month The procedure and the the of about treatment months. conservative informed end 6 the were the patients of for at two methods loss least conservative weight at these of and from all gabapentin, failure pregabaline, of clothing, a therapy, MRI physical to looser (NSAIDs), the due drugs amitriptyline, clinic in anti-inflammatory our nonsteroidal disease to as lumbar such referred of methods, groups sign both no in was patients All there and patients the (SNCV). all patients. velocity to the conduction performed nerve was potential (MRI) sensory action imaging nerve reduced sensory or attenuated showing amplitudes studies electrodiagnostic (SNAP) by confirmed were patients the All 13 l h ainsi ohgop eeavsdt pl oa c otertihadto and thigh their to ice local apply to advised were groups both in patients the All 3 12 10,11 15 8,13,14 hnterdooitmoved radiologist the Then pnlmgei resonance magnetic Spinal l S examinations USG All Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. ntedge fnmns.Atog h ubeswsrsle nalptet nGop2a h n fthe of end the at 2 Group in patients Group all the in than resolved greater was was numbness the 2 the Although Group to numbness. in and of due month month, degree was first first the degree and post-injection period in the week the that follow-up first till reported the week post-injection groups ( first at of both 1 post-injection numbness in end patients the of the the in degree All time at the 1. with Group aggravated groups in score was two VAS patients numbness 4 mean the of of post-injection of symptoms the the scores pain period of VAS until follow-up recurrence the mean period of mean post-injection end patients The 2.9 the the the was period. At of 1 follow-up 2. None the Group Group symptoms. of in in the end 12-18) 14.8 of (range: the was recurrence months at sensitivity had 2.0 symptoms cutaneous 4 post-injection they in the the period improvement period in of improvement follow-up and sensitivity follow-up recurrence partial the relief cutaneous the had of and in of 2 and end pain end Group pain the in the in in At recovery improvement at injection. full partial but the or declared year partial with first 2 had satisfied period Group 1 also follow-up Group in were the in patient and they patients of relief but 1 end pain sensitivity full and the declared cutaneous At 1 2 in satisfied. Group Group in completely patients in were 10 patients and they 1 2 and Group sensitivity in scores, patients cutaneous VAS 9 in period mean improvement follow-up symptoms, the of of end duration the groups. At two scores, the 12.4 ASA between was BMI, period patients age, follow-up the gender, and of the hospital between 7.6 the difference was 12.1 significant to 1 and admission Group 1 and in Group pain score in of months onset 11-14) the (range: between interval mean of 29 28.4 The 42.2 was was duration was 1 2 1 and Group Group Group grade, in and baseline (ASA) patients at 24-33) Anesthesiologists other the (range: each of 40.8 of to was age similar Society 2 mean were Group American groups The The 3). age, follow-up. (Table to gender, symptoms lost as were groups such both demographics in patients the of features None clinical patient and Demographics 3.1 were analysis. patients RESULTS statistical of perform satisfaction to the VAS variance. and used in numbness of was change of treatment The 20.0 analysis degree and index). repeated-measures The grade, mass variance. by ASA body of (gender, analysed (age, analysis data data Two-way count measurement by were for for analysed comparisons test was t-test The exact independent-sample t-test. Fisher’s the with or and analysis an test level), statistical at chi-square the differences the before detect means using to performed the performed power was as 80% test presented provide normality are to A results required The percentage. was significance. group indicate per to patient 0.05 10 of size sample were A ethanol and preparation covering). 75% skin sterile of pathological analysis (appropriate patient showed mL Statistical conditions USG and 3 sterile 2.5 where transducer, minutes in level and needle 3 the 23G gel after at a USG and using LCFN sterile betamethasone by mg/mL the disinfection, of calibre, 5 around mL nerve bupivacaine tenderness, 1 the of minutes maximal of 3 mL of alterations after site 2 and the 2, mg/mL into 5 Group bupivacaine injected in of mL and 2 mg/mL, 1, 40 Group was swellling, in hypoechoic LFCN guidance, show USG the Under can of USG site. signature entrapment technique structure. the echo Injection oval in the 2.4 hypoechoic fibrosis until typical perineural and a direction enlargement, as mediocaudal area seen cross-sectional a was in LFCN gently determined. transducer ultrasound the p < .5.Hwvr oeo h ainsi ohgop opandaotteps-neto aggravation post-injection the about complained groups both in patients the of none However, 0.05). ± ± ± . kg/m 2.5 . rne 15)yas h enflo-ppro fGop1ws28.7 was 1 Group of period follow-up mean The years. 31-52) (range: 7.3 . rne -) n nGop2ws1.8 was 2 Group in and 1-7), (range: 2.3 ± .5(ag:69,adi ru a 7.5 was 2 Group in and 6-9), (range: 1.05 2 rne 433.)adi ru a 30 was 2 Group in and 24.3-32.3) (range: ± . ots(ag:2-4.Tema oyms ne BI in (BMI) index mass body mean The 24-34). (range: months 2.7 ± . rne 01)i ru .Tepeijcinma VAS mean pre-injection The 2. Group in 10-14) (range: 1.2 4 p < ± .5wscniee ttsial infiat SPSS significant. statistically considered was 0.05 . ots(ag:1-9 nGop1ad14.5 and 1 Group in 12-19) (range: months 1.8 ± . rne -) h ieecsbetween differences The 1-3). (range: 0.7 ± tnaddvain(D,nme,and number, (SD), deviation standard ± ± 14 .3(ag:69.Teewr no were There 6-9). (range: 1.03 ± . rne 75)yasadin and years 27-55) (range: 8.4 . kg/m 3.4 14 2 rne 22.9-34.3). (range: ± . months 2.6 α ee of level ± 0.9 ± Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. aeteia olresuyhseautdteueo loo erlssi hscontext. this in meralgia of neurolysis treatment alcohol the of in use method effective the paresthetica. and evaluated meralgia safe has treat a study to being large effective neurolysis no alcohol been of paresthetica, has reports LFCN isolated the structure, been nerve of agent. the used. used neurolysis destroying when directly, widely Alcohol 99.5% nerves most than the the contacting greater conduction. by is is nerve patients alcohol concentration blocking in clinics, the and relief the pain and provides transparent, in alcohol and used The colorless are quasi-RCTs is agents or alcohol neurolytic (RCTs) Dehydrated of trials kinds controlled weak. many randomised is Although published injections any corticosteroid of local absence of effect the the evidence. of limited because that a reported has neurolysis have effective alcohol be drugs guidelines to whereas shown these or series. been although have case methylprednisolone protocols treatment, or in clear betamethasone the dexamethasone, no for triamcinolone, as tried and such been effects. paresthetica have adverse meralgia amitriptyline significant of and treatment gabapentin, predominance. the Pregabaline, male on a reported. concensus with are 55 no 65. and and are 27 30 between There were of patients ages the the of between ranges age especially group, predominance, age genders. male any the a in reported seen con- authors most be be anaesthetic can local can paresthetica with blocks diagnosis Meralgia positive and the study conduction amplitude and nerve groups. side-to-side positive both findings the with in of SNAP clinical both of were the there amplitude patients, the our on in decrease based showing is studies difference. conduction paresthetica nerve meralgia by firmed of harvesting. graft diagnosis bone hernia The iliac laparoscopic nerve the and appendectomies), the of osteotomies, and periostitis incisions of pelvic scoliosis, (Pfannenstiel streching Chiari discrepancies, incisions tumors, repairs, length pelvic tight retroperitoneal leg and pregnancy, standing, obesity, abdominal and lower overuse, prolonged pelvic ilium, hyperextension, trauma, belts, leg to prolonged hip due to loaded ocur due heavily can wearing it but clothing, idiopathic fitting usually local is and paresthetica infection, Meralgia as the such complications, of the other with aggravation no satisfied the aggravationDISCUSSION were were However, patients The There these patients. 2. period. recorded. all Group follow-up all were and the in toxicity the day of patients second anesthetic of end 3 post-injection satisfaction the in the at at and and injection resolved 1 cooperation patients Group these the severe 1 in in induced Group affected patients pain injection in 3 pain corticosteroid patients in and the 3 injected neurolysis of polysulfate of alcohol when skin mucopolysaccharide The reaction) the mg drainage period. (flare in 445 requiring follow-up discoloration pain last with without The skin the treated hematoma skin. in the was local the recovered in hematoma over was had discloration applied with 2 cream had patient Group polysulfate) 1 The in (chondroitin Group site. patient in injection 1 patients the and Three at injection injections. corticosteroid the the and after after 1-week complications at some ( were groups period There both follow-up in the of patients first end of Complications post-injection the 3.2 ratio the at satisfaction ( 1 from differ Group The numbness significantly than of period. not greater follow-up recurrence did was injection the the the of reported after 1 end 1-month Group the in till patients year 4 period, follow-up 1,11 21 23 7,23,25,26 nsm ae h igoi a ecnre yteLF lc ihlclanaesthetic. local with block LCFN the by confirmed be can diagnosis the cases some In ooeaietetet uha SIs et n hsclteayi sal sucessful. usually is therapy physical and heat, NSAIDs, as such treatment, Nonoperative hra,teeaesm uhr eotdafml predominance. female a reported authors some are there Whereas, napopciesuyteei oeeiec fprnua otcseodinjections, corticosteroid perineural of evidence some is there study prospective a In 16,23 29 oa nshtcaetijcin iho ihu eierlcorticosteriod perineural without or with injections agent anesthetic Local 3,19,20 27 1,5,13 nyRsnhc eotda qa itiuinbetween distribution equal an reported Rosencheck only 5 p ohaemt-nlsso bevtoa studies observational of meta-analysis Cochrane A < .5.Hwvr h aifcinrtoi ru 2 Group in ratio satisfaction the However, 0.05). p < 0.05). 3,16,17 3,22 5 npeetsuy the study, present In oee,teehave there However, 5,30 hne al. et Chen 3 Although 18 In 24 28 28 Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. eddnticueapaeocnrlgopi u td.Adtoal,teutaon ucmswr not were outcomes ultrasound the randomized, prospective, Additionally, a Second, study. However, study. patients. our retrospective of a in and number is study inclusion group larger Our the control a method. from by blinded placebo a resulted support using a which further by evaluated groups, include injection needed both corticosteroid not some results in have of The did patients did study. use we study of our the present number for compare the small criteria to However, a exclusion designed paresthetica. had meralgia study we of first First, treatment the the limitations. is for ours neurolysis knowledge, alcohol our and of best the To patients’ improve period day. can post-injection second Limitations this the post-injection injections in 4.1 and the patients the their at period before in resolved post-injection relief patients block pain the these LCFN partially in in neurolysis. get the relief al. nerve patients, is et pain the pain Akural our some of and post-injection in al. provide The et As can hours. Kim anesthesia. site satisfaction. 24 local lesion post-injection inadequate approximately the in the at resolved of hours. groups 72 because both within not spontaneously in resolves patients corticoste- and all the injection in effect, irritant. the anti-inflammatory after local an later a has traumatic hours as and injection acts ana- corticosteroid corticosteroid crystal of different the roid doses although to at larger that 1% with injection determined approximately related corticosteroid They was in reaction to incidence flare due flare the injections. 81% that inflammatory reported to post-injection studies. Hollander 1% various reported 2%. by reaction and reported injections flare been corticosteroid of low have incidences the locations than of tomical block range plane wide abdominal transversus widened. A neurolytic be in may site, anesthesia, alcohol previously, alcohol. lesion the injected of of the is as concentration concentration to anesthetic injected high injection local is with the the which relief when for alcohol, pain Second, diluted of decreases. both range anesthetic are diffusion local agent the the anesthetic irritation. of local local effect and analgesic to alcohol the due the pain when severe First, effective. temporary effect. found induce was can alcohol nerves. injection of sciatic Alcohol rat amount the this on and alcohol patients 75% and our concentration. 50% to alcohol the the degree. than increasing effective injury reduction more by nerve was 50% increased the had be increases patients can concentration all alcohol alcohol and of relief effect curative pain The complete had methylprednisolone patients and injections. 75% anesthetic follow-up corticosteroid local symptoms. of the third in the months after the patients 16 from after their the patients benefit of After 14 50% any 22 in in and have in relief injection, injection. pain not occured second reported benefit relief did the al. any after et Complete patients have Tumber patients injection. 10 12 not neurolysis betamethasone However, in did alcohol injection, by who injection. first patients injection treated Twenty-one the patients. 58 at were corticosteroid after 79 patients remaining treatment patients of the all The conservative study with treatment. retrospective in the conservative al. compared scores from et by VAS when Haim treated the patients. and were decreased of patients period satisfaction neurolysis the follow-up alcohol improved the more the much that of showed end results implemented This the The successfully scores. was patients. VAS neurolysis alcohol reduced all and paresthetica. the injection in marelgia corticosteroid by LFCN of study, indicated treatment retrospective as this the In neurolysis neurolysis. in alcohol alcohol effective with nerve was splanchnic relief alcohol with pain that patients had meant the patients of block. all plane pain study, abdominal cancer this transversus of abdominal neurolysis neurolysis. upper alcohol with alcohol decreased pain Fujita with wall abdominal paresthetica malignant meralgia of control recurrent term for relief pain provided 3,34 38 lvrs ta.rpre ootsuyo ainstetdwt racnln injections. triamcinolone with treated patients 8 of study cohort a reported al. et Elavarasi h aerato fe otcseodijcinwssuidi ealb cat n Hogan. and McCarty by detail in studied was injection corticosteroid after reaction flare The 23 41,42 31 hr a aerato nbt forgop n h grvto ftepain the of aggravation the and groups our of both in reaction flare was There 39 h aerato u ocriotri neto sal trsafew a starts usually injection corticosteroid to due reaction flare The 6 35 37,38 nasuy twsepaie ht9.%alcohol 99.9% that emphasized was it study, a In olne a rae 0.0 ainswith patients 100.000 treated has Hollander 35 40 35,36 eijce Lo 5 ethanol 75% of mL 3 injected We norsuy h aereaction flare the study, our In 5 hr r w asso this of causes two are There uge l eotdlong- reported al. et Hung 35 uge l o longer got al. et Hung 35 yices nthe in increase By 33 vn and Ivins 32 In 31 Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. o l set ftewr nesrn htqetosrltdt h cuayo nert faypr fthe of part any of integrity or accuracy the to related questions REFERENCES resolved. that and ensuring accountable investigated are in authors appropriately work The are committee. the work ethics of and aspects board review all institutional for our by approved was study The STATEMENT authors. ETHICAL the from request on available Data and study not of is parts or STATEMENT AVAILABILTY all DATA to, in submitted manuscript. involved been the were not of authors has review All it and journal. that literat authors, another including the in preparation all manuscript publication by for approved and consideration read under been received sectors. has research not-for-profit manuscript This or The disclose. commercial, public, to the interest in of CONTRIBUTIONS agency conflicts AUTHOR funding no any have from they grant that specific declare no hereby authors named All DISCLOSURE INTEREST OF CONFLICT effect. curative None. long-term treatment and both are satisfaction injection, patients’ neurolysis corticosteroid the alcohol ACKNOWLEDGEMENTS in improved higher and and are pain injection rates the corticosteroid recurrence decreased the persisted methods Although has methods. paresthetica effective meralgia both once conclusion, paresthetica. In meralgia of trials treatment treatment these future outcomes. of the for CONCLUSION of handicaps 28- information assessment and mean valuable comprehensive 28-month the benefits provides mean at study more the present patients included reveal important study The might 26 our another studies in period of Thus, strengths changes double-blind follow-up The results. these placebo-controlled, longer methods. changes all the a randomized, the patients, Finally, for prospective, to the affected needed. controlling more due of have are in Therefore, level was could difficulty activity this period. the clothes in period. follow-up of was increase in follow-up month reason study The changes the The our 1. and of of 2. Group end limitation gain, Group in patients weight the in 4 lifestyle, at better of was in groups used. symptoms between scores improvement both not the VAS was for was of there mean agent recurrence scores that in contrast VAS shown not improvement have a mean did the series because post-injection we However, our clear of and addition, results not MRI. pre-injection In the or was the effects. factors, imaging alcohol many ultrasound individual or by post-treatment their limited corticosteroid and study Although show pre-treatment injected our using to of of lesions not distribution LFCN aim The the methods, primary of treatment the changes two Nonetheless, the study. assess the ideal compare an to be was would study double-blind placebo-controlled, Klge A igeL.Mrli aeteiammciglma radiculopathy. lumbar mimicking paresthetica Meralgia LJ. patients. Tingle adult 14 MA, with experience tran- Kallgren clinical by diagnosis: 4. elusive caused the paresthetica, be Meralgia GK. may Ivins syndrome 3. paresthetica-like Meralgia cutaneous femoral P. lateral Dharmasaroja of neurolysis P, alcohol Dharmasaroja Ultrasound-guided 2. AK. Kochhar D, Arora A, Ahmed 1. in ubrnrero nuywtotdfiiecmrsin aereport. case a 1993;76(6):1367-1368. compression: definite without Surg. injury root nerve Thai. lumbar sient series. case a paresthetica: meralgia intractable for nerve 2000;232(2):281-286. 2010;93(Suppl.7):S307-310. r eerh td ein nlsso aa aucitpreparation, manuscript data, of analysis design, study research, ure ¨ 7 rJPain. J Br 2016;10(4):232-237. nshAnalg. Anesth e Assoc Med J Ann Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. JcsnT,GeaR erltcbok revisited. blocks Neurolytic R. Gaeta paraesthetica. TP, Jackson meralgia for 28. Treatment W. know. Rakowicz to A, needs Nicotra anesthesiologist N, an Khalil what 27. paresthetica: multimo- a Meralgia paresthetica: PW. meralgia Peng of GK, Management Hui P. treatment 26. Mandal the TS, in Jayalakshmi nerve V, cutaneous Gulaya femoral GP, lateral Dureja the to of way 25. Decompression efficient NS. and Taylor easy AL, an Dellon triamcinolone I, Is Ducic MV. Srivastava 24. patients. Padma vertebrae. MB, Singh 67 spinal paresthetica. V, meralgia the Goyal of of A, of Elavarasi Management osteoarthritis KP. 23. Trzil review to PH, relation Williams A its 22. – paresthetica. paresthetica Meralgia Meralgia C. Rosencheck J. 21. Simpson C, paresthetica. paraesthetica. Meralgia Kitchen Meralgia J. 20. TD. Zundert Van Sharma M, LS, Kleef Chawla van PN, A, Chhuttani paresthetica. Lataster meralgia 19. S, of Hayek treatment N, and Mekhail J, diagnosis Patijn Ultrasound-guided L. 18. Ozcakar AM, nerve Ata cutaneous SS, Onat femoral lateral 17. meralgia the of of assessment neuroplasty the percutaneous in Ultrasound-guided ultrasonography SW. High-resolution Mulvaney C. 16. Martinoli L, MS, Taljanovic Padua M, A, Sojer Tagliafico A, Tagliafico 15. C, Martinoli I, Sporer EJ, Halpern MM, Ellah treatment Abd Ultrasound-guided AS, C. Klauser Martinoli 14. V, Valsania N, Perrone F, Lacelli G, combined Serafini thermocoagulation A, Radiofrequency Tagliafico JX. Ni 13. BS, Wu LQ, Yang MW, He cases. Q, 120 Wang in WX, diagnosis Zhao electrophysiological and 12. clinical electrophysiologic paresthetica: of Meralgia value R. prognostic Seror and P, Seror Diagnostic A. 11. Durandeau P, Deliac MM, Deliac A, Lagueny 10. Bde ,Brahv ,GlaoK uzD atnl ,FlengM lrsudo h la- taping: the Kinesio of using paresthetica Ultrasound meralgia of M. symptoms Felfernig Relieving L. C, Volchek E, Martinoli Vered L, strategies. D, Kalichman Putz management 9. K, and Galiano diagnosis M, Bernathova paresthetica: G, Meralgia Bodner of J. management 8. the Patijn for radiofrequency D, recurrent pulsed for duration Harney nerve Extended 7. cutaneous S. Loganathan femoral D, lateral Dhiman of B, neurolysis Ghai Alcohol MA. 6. Saman VE, Phui CK, Chen 5. 2008;3:CD004159. Med. regimen. dality paresthetica. meralgia of study. cohort A paresthetica? meralgia treat 1925;85(6):416-418. 1972;48(5):547-555. 490. Pract. ultrasound-guided new a of Physician. description Pain and report case a paresthetica: meralgia technique. of treatment the for needed. are 12-month clarifications with some paresthetica: levels multiple at injection Ultrasound-guided paraesthetica: follow-up. Meralgia of WR. results Jaschke and description technical patients. neuropathy): consecutive cutaneous 20 femoral in treatment (lateral paresthetica meralgia neuralgia. of trigeminal of complications postoperative relieve Res. helps Mol radiofrequency pulsed with Nerve. paresthetica. meralgia in tests volunteers. in and study. cadaver pilot a a in findings normal nerve: Med. cutaneous femoral teral 2007;8(8):669-677. cases. five of series a paresthetica: meralgia refractory paresthetica. meralgia 2009;34(3):265-268. 2011;36(2):156-161. 2006;33(5):650-654. 2011;11(3):302-308. 2015;14(3):7616-7623. urSot e Rep. Med Sports Curr u Radiol. Eur rhPy e Rehabil. Med Phys Arch nshAnalg. Anesth 2016;19(4):E667-669. Agri. 2016;26(3):764-770. eosrMicrosurg. Reconstr J 2012;24(1):42-44. 1995;80(5):1060-1061. uceNerve. Muscle 2011;10(2):99-104. lrsudMed. Ultrasound J 2010;91(7):1137-1139. uceNerve. Muscle 1991;14(1):51-56. n ninAa Neurol. Acad Indian Ann 8 2006;22(2):113-118. urPi edceRep. Headache Pain Curr oenJPain. J Korean 2011;30(10):1341-1346. 2012;45(6):922. Neurosurg. J caNuo Scand. Neurol Acta 2018;31(3):215-220. 2019;22(3):308-310. ohaeDtbs ytRev. Syst Database Cochrane 1991;74(1):76-80. 2008;12(1):7-13. caNuo Scand. Neurol Acta e nshPain Anesth Reg e nshPain Anesth Reg 1966;42(4):483- anMed. Pain JAMA. Muscle Genet Pain Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. al 2: Table 1: Table KmB,N Y a J akC,KmJ.Prpei olwn necsa ev erlsswith neurolysis nerve intercostal following Paraplegia JH. Kim CH, Park SJ, Han MY, No BH, Kim 42. J RO, preparations: Ojala anesthetic E, local microcrystalline Akural and of corticosteroid 41. Injectable injection EC. Kavanagh intrasynovial SJ, after Eustace reaction PJ, MacMahon Inflammatory 40. JM. Hogan Jr, arthritis. extra-articular DJ in of therapy McCarty effects corticosteroid Adverse 39. Intrasynovial SM. JL. Bierma-Zeinstra Hollander JA, Verhaar 38. AC, Volkers BW, Koes A, nerve tibial Brinks of neurolysis 37. alcohol point and lesion phenol of alcoholic Comparison the OM. Ozerbil of AH, upstream Demir A, Anesthesia Salli H. H, Kocabas Zhou C, 36. Meng M, Wang L, Niu Y, Liu marelgia for J, block Kang nerve cutaneous 35. femoral lateral patients Ultrasound-guided 79 VW. Chan of A, analysis Bhatia retrospective PS, a Tumber paresthetica: plane Meralgia 34. abdominal S. Dekel alcohol. transversus P, Ben-Galim with Neurolytic T, block Pritsch A. nerve A, splanchnic Haim Gulati neurolytic V, 33. CT-guided Malhotra Y. Fujita V, 32. Puttanniah N, Azam nerves. JC, elbow digital Hung relieve of neurolysis to 31. Alcohol nerve CJ. musculocutaneous Burnett of GK, Wright neurolysis EL, Walker alcohol guided 30. Ultrasound SH. Jang DG, Lee 29. Hsoyo plpy ye1o ibtso eaooi disease hematologic or diabetes 2 or 1 type epilepsy, lateral of the History to prolotherapy) 7. plasma, platelet-rich corticostreoid, analgesic, (local injection previous cases Any uncooperative 6. and barriers paresthetica Communication meralgia 5. for surgery Previous 4. index mass Body 3. paresthetica meralgia Bilateral 2. lactation or Pregnancy 1. antiinflammatory nonsteroidal therapy, physical including modalities, laparoscopic treament or to open respond to incision, Failure Phannenstiel 7. by surgery urological) or (gynecological intensity III abdominal pain to for No I score grade 6. scale score analog (ASA) Visual Anesthesiologists 5. of months Society 6 American [?] 4. index for mass thigh anterolateral Body on 3. numbness or Pain 2. years [?]18 Age 1. uaeu eoa nerve femoral cutaneous or amitriptyline and vascular gabapentin, extremity osteotomies, pregabaline, affected pelvic drugs, or hip harvest, affected graft pelvis, bone the to iliac operation appendectomies, orthopaedic or herniorrhaphy inguinal patient. cancer lung in patients injection cancer epidural in thoracic pattern and sprerad alcohol injection and effect infiltration. of tumor evaluation celiac an with ablation: plexus celiac rolytic radiologists. for review a esters. adrenocorticosteroid randomized review. a systematic stroke: a after injections: foot corticosteroid spastic of treatment for muscle study. clinical pilot gastrocnemius randomized controlled the prospective to a branches motor neuralgia: intercostal for neurolysis alcohol of trial. pain the alleviates paresthetica. algorithm. standard a to according treated and evaluated control. pain related malignancy long-term for alcohol with block 2016;29(3):331-332. patients. stroke hemiparetic in spasticity xlso rtrao h study the of criteria Exclusion study the of criteria Inclusion lnc SoPaulo). (Sao Clinics nshAnalg. Anesth > < 5kg/m 35 kg/m 35 u hsRhblMed. Rehabil Phys J Eur ¨ arvim Radiology. 2020;75:e1296. rhii Rheum. Arthritis 2008;106(3):1021-1022. 2 2 k ,KrneiJ evnnO,Bac euio .M-uddneu- MR-guided R. Sequeiros Blanco OA, Tervonen J, Kariniemi V, ¨ aki adoacItretRadiol. Intervent Cardiovasc 2009;252(3):647-661. NeuroRehabilitation. > 1964;7:359-67. o atcpn’ efassmn fpain of self-assessment participant’s for 5 M uklsee Disord. Muskuloskelet BMC 9 2010;46(1):5-10. caOrthop. Acta 2013;36(2):472-478. dSaeMdJ. Med State Md oenJPain. J Korean 2012;31(4):373-377. anPhysician. Pain Pain. 2006;77(3):482-486. rc(alUi e Cent). Med Univ (Bayl Proc 1993;55(3):363-366. 2010;11:206. 2015;28(2):148-152. 1970;19(3):62-66. 2014;17(6):E755-760. Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. aibeGop1Gop2 Group 2 9 5 6 1 Group 42.2 3.docx Table file Hosted 28.7 4 11 of-meralgia-paresthetica-during-a-28-month-follow-up-period-a-retrospective-cohort-study 12.4 5 10 4 of-ultrasound-guided-corticosteroid-injection-and-alcohol-neurolysis-in-the-treatment- 7 2.docx Table file Hosted of-meralgia-paresthetica-during-a-28-month-follow-up-period-a-retrospective-cohort-study of-ultrasound-guided-corticosteroid-injection-and-alcohol-neurolysis-in-the-treatment- 1.docx Table file Hosted 6 9 3: Table II Grade I Grade (n) score (ASA) Anesthesiologists of Society Range American Mean (mo) period Range Follow-up Mean (mo) duration Symptom (kg/m BMI Range Mean (y) Age Left Right extremity Affected Female Male (n) Gender Variable Hsoyo evs i rfmrijr fe eagaprshtc ramn a tre hog the through started had treatment paresthetica meralgia after injury femur or hip pelvis, bupivacaine to of reaction History level allergic protein 30. or C-reactive sensitivity or Known rate 29. sedimentation erythrocyte Abnormal 28. pacemaker failure Cardiac renal 27. or liver Cardiac, syndrome pelvis 26. pain or regional extremity Complex affected the 25. in bursitis infection Trochanteric skin 24. or bone Joint, 23. infection extremity Tuberculosis affected and 22. pelvis infection the Systemic of 21. periostitis or Osteomyelitis 20. Scoliosis syndrome 19. discrepancies piriformis length or Leg radiculopathy 18. lumbar of History tumors cyst 17. retroperitoneal or and tumor Pelvic pelvis bone or 16. femoral hip or the Pelvic of spondylo- 15. tendinopathy spondylolisthesis, of stenosis, History spinal lumbar 14. venous herniation, disc deep (lumbar as disease lumbar such of site disease, History injection vascular 13. the peripheral around Effusion or 12. autoimmune inflammatory systemic of History arthritis 11. gout of History 10. Atrtso h evs i rknee or hip pelvis, the fracture of femur Arthritis or 9. hip pelvis, Previous 8. 6mnhflo-ppoint follow-up 36-month imaging resonance magnetic in spondyloarthritis) sis, disorders bleeding or thrombosis eorpi ain data patient Demographic 2 enRne29.0 Range Mean ) vial at available at available at available https://authorea.com/users/417637/articles/524653-effectiveness- https://authorea.com/users/417637/articles/524653-effectiveness- https://authorea.com/users/417637/articles/524653-effectiveness- 10 ± ± ± ± . 4–3 28.4 12.1 33 – 24 40.8 2.6 30.0 14 - 11 1.1 32.3 – 24.3 2.2 55 - 27 9.0 ± ± ± ± . 4-34 - 24 3.1 14 - 10 1.4 34.3 – 22.9 3.3 52 - 31 7.38 Posted on Authorea 2 Jun 2021 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.162266026.60810954/v1 — This a preprint and has not been peer reviewed. Data may be preliminary. of-meralgia-paresthetica-during-a-28-month-follow-up-period-a-retrospective-cohort-study of-ultrasound-guided-corticosteroid-injection-and-alcohol-neurolysis-in-the-treatment- 11