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Mouse TGFBR3 / Betaglycan Protein (His Tag)

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Mouse TGFBR3 / Betaglycan Protein (His Tag) Mouse TGFBR3 / Betaglycan Protein (His Tag) Catalog Number: 50542-M08H General Information SDS-PAGE: Gene Name Synonym: 1110036H20Rik; AU015626; AW215636; TBRIII Protein Construction: A DNA sequence encoding the extracellular domain of mouse TGFBR3 (NP_072075.2) (Met 1-Arg 399) was expressed, with a polyhistidine tag at the C-terminus. Source: Mouse Expression Host: HEK293 Cells QC Testing Purity: > 95 % as determined by SDS-PAGE Endotoxin: Protein Description < 1.0 EU per μg of the protein as determined by the LAL method Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate Stability: proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as Samples are stable for up to twelve months from date of receipt at -70 ℃ a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB Predicted N terminal: Gly 23 signaling. Decreased expression of this receptor has been observed in Molecular Mass: various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 The recombinant mouse TGFBR3 consists of 774 amino acids and has a knockdown led to focus formation and enhanced expression of CD133, a predicted molecular mass of 86.3 kDa. In SDS-PAGE under reducing marker found on prostate cancer stem cells. TGFBR3 is an accessory conditions, the apparent molecular mass of rmTGFBR3 is approximately receptor that binds to and modulates the activities of both transforming 80-90 kDa due to glycosylation. growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive Formulation: biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis. Lyophilized from sterile PBS, pH 7.4 References Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in 1.Johnson DW, et al. (1996) Assignment of human transforming growth the hardcopy of COA. Please contact us for any concerns or special factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to requirements. 9q33-q34 and 1p32-p33, respectively. Genomics. 28 (2): 356-7. 2.Rotzer D, et al. (2001) Type III TGF-beta receptor-independent signalling of TGF- Usage Guide beta2 via T betaRII-B, an alternatively spliced TGF- type II receptor. EMBO J. 20 (3): 480-90. 3.Gao J, et al. (1999) Expression of transforming growth Storage: factor-beta receptors types II and III within various cells in the rat periodontium. J Periodont Res. 34 (2): 113-22. Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: Detailed reconstitution instructions are sent along with the products. Manufactured By Sino Biological Inc., FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS. For US Customer： Fax: 267-657-0217 Tel：215-583-7898 Global Customer： Fax :+86-10-5862-8288 Tel:+86-400-890-9989 http://www.sinobiological.com.
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