€60,000,000,000 Euro Medium Term Note Programme

FIRST SUPPLEMENT DATED 29 OCTOBER 2010 TO THE BASE PROSPECTUS DATED 22 OCTOBER 2010 UNICREDIT S.p.A. (incorporated as a Società per Azioni in the Republic of Italy under registered number 00348170101) and UNICREDIT BANK IRELAND p.l.c. (incorporated with limited liability in Ireland under registered number 240551) UNCONDITIONALLY AND IRREVOCABLY GUARANTEED BY UNICREDIT S.p.A. in the case of Notes issued by UniCredit Bank Ireland p.l.c. €60,000,000,000 Euro Medium Term Note Programme This first Supplement (the Supplement) to the Base Prospectus dated 22 October 2010 (the Prospectus), constitutes a supplement for the purposes of Article 13.1 of Chapter 1 of Part II of the Luxembourg Act dated 10 July, 2005 on prospectuses for securities (the Prospectus Act) and is prepared in connection with the € 60,000,000,000 Euro Medium Term Note Programme (the Programme) established by UniCredit S.p.A. (UniCredit) and UniCredit Bank Ireland p.l.c. (UniCredit Ireland, and together with UniCredit, the Issuers). Terms defined in the Prospectus have the same meaning when used in this Supplement. This Supplement constitutes a Supplement to, and should be read in conjunction with, the Prospectus issued by the Issuers. Each of the Issuers and the Guarantor accepts responsibility for the information contained in this Supplement. To the best of the knowledge of each of the Issuers and the Guarantor (which have taken all reasonable care to ensure that such is the case) the information contained in this Supplement is in accordance with the facts and contains no omissions likely to affect its import. In accordance with Article 13.2 of Chapter 1 of Part II of the Prospectus Act, investors who have already agreed to purchase or subscribe for the securities before this Supplement is published have the right, exercisable within a time limit of minimum two working days after the publication of this Supplement, to withdraw their acceptances. Copies of this Supplement and the document incorporated by reference in the Supplement will be available on the Luxembourg Stock Exchange website (www.bourse.lu). UniCredit Board of Directors Approves New Managerial Governance On 26 October 2010, the UniCredit Board of Directors, at the request of the CEO Federico Ghizzoni, has appointed Roberto Nicastro as General Manager. In this role, Nicastro will lead the Group’s commercial banking business, which is comprised of the Families, Small and Medium-Sized Enterprises and Private Banking segments as well as the Global Transaction Banking. The Board also appointed Paolo Fiorentino as Chief Operating Officer (COO) making him responsible for Operations, IT, Organization, HR and Identity&Communications. Sergio Ermotti has agreed, until his successor is appointed and in order to assure a smooth transition, to continue to head the Group’s Corporate and Investment Banking (CIB), composed by Markets, Financing&Advisory, Financial Institutions Group, Leasing and Factoring. The Board has underlined the strategic importance of the CIB-area for UniCredit. The General Manager, the COO, the Head of CIB, the Chief Financial Officer and the Chief Risk Officer will all report directly to the CEO. Ghizzoni will also oversee Strategic HR and manage the country chairmen for Germany and Austria. The country chairmen for Italy and Poland, along with the Head of CEE Banking Operations, will report to the General Manager. The following information shall be incorporated by reference in, and form part of, the Prospectus: Document Information incorporated Page Reference Press Release dated 26 Entire Document All October 2010 To the extent that there is any inconsistency between (a) any statement in this Supplement or any statement incorporated by reference into the Prospectus by this Supplement and (b) any other statement in or incorporated by reference in the Prospectus, the statements in (a) above will prevail. 2.

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