618 Antihistamines
2. Paton DM, Webster DR. Clinical pharmacokinetics of H1-receptor Uses and Administration antagonists (the antihistamines). Clin Pharmacokinet 1985; 10: 477-97. Brompheniramine maleate, an alkylamine derivative, is a sedating antihistamine with antimuscarinic and moderate Preparations ...... sedative actions. ProprietaryPreparations (details are given in Volume B) Brompheniramine is a racemic mixture; dexbromphe niramine, the dextrorotatory isomer, has about twice the Single-ingredient Preparations. Fr.: Dimegan; Gr.: Dimetane; activity of brompheniramine by weight. Brompheniramine Hong Kong: Bromitont; Malaysia: Bomex; Singapore: Bomex; maleate and dexbrompheniramine maleate are used for the Thai.: Babycoldt; Bomine; Bromma; Bromphen; Bromsin; symptomatic relief of allergic conditions, mainly rhinitis Dimetanet; Probrom; USA: Alahist IR; Bidhistt; J-Tan; Lodrane (p. 612.1) and conjunctivitis (p. 611.1). They are common 12t; Lodrane 24t; Oraminic II; P-Text. Pharmacopoeias. In US. ingredients of compound preparations for the symptomatic Multi-ingredient Preparations. Arg.: Factus; Austral.: Dirnetapp 611.2). USP 36: (Bromodiphenhydramine Hydrochloride). A white treatment of coughs and the common cold (p. DM; Dimetapp; Braz.: Bialerge; Decongex Plus; Dimetapp; to pale buff-coloured, crystalline powder having no more Bromphenirarnine tannate has been used similarly. Winter AP; Canad.: Cold And Allergy Liquidt; Cold Syrup; Brompheniramine maleate than a faint odour. Soluble in less than of water, in 2 of is given in usual oral doses of Dimetane Expectorant C; Dimetane Expectorant DC; Dimetapp alcohol and of chloroform, I in 3500 of ether,I and 1 Iin 31 of 4 mg every four to six hours. It has also been given by Chewables for Kids; Dirnetapp Coldt; Dimetapp DM Cough & Cold; Dimetapp·C; Dimetapp; DM Cough and Cold; Drixoral isopropyl alcohol; insolubleI in petroleum spirit. Store in subcutaneous, intramuscular, or slow intravenous injec Day/Nightt; Drixoral; Drixtabt; Extra Strength Cold Syrup: airtight containers. tion. Dexbrompheniramine maleate is normally given as an Extra Strength DM Cough and Cold; Oral Infant Cold Dropst; (�'i'); (il'PTJl!t); (!J;Pf'l(); ingredient of decongestant preparations containing pseudo China: Coleta! Neosed Rhinobol Cz. : Profile ephedrine. The dose of dexbrompheniramine maleate in Disophrol; Gr.: Dimetapp New; Dimetapp; Disofrin; Hong Kong: Arnericat; B.P.P.t; BPP Cough Syrupt; Brorn-PP; Brom these oral combinations is 6 mg no more than twice daily. Bromazine hydrochloride, a monoethanolamine derivative, Ramine Compound; Bromphenext; DF Multi-Symptomt; Modified-release oral preparations of brompheniramine is a sedating antihistamine (p. 610.1) with antimuscarinic Dimeta-2; Dimetapp; Drixoralt; Eascold; Eurotapp; Fastolint; and marked sedative actions. It has been used in maleate or dexbrompheniramine maleate are available in Fludanet; Futalint; Futarat; Mecostopt; Unihist; Vidatapp combination preparations for the symptomatic treatment some countries; dosage is specific to a particular Fortet; Vidatappt; Indon.: Alco Plus DMP; Alco Plus; Drixoral; of coughs and the common cold. formulation. Irl. : Dimotane Cot; Tlvico; Malaysia: Rinafort; Unihist; Mex.: For dosage in children, see below. Afrinext; Cripofen; Dimetapp; Sedalmerck Flu; NZ: Dimetapp DM Cold & Cough; Dimetapp; Philipp.: Bromitapp; Dimerrin; Administration in children. Brompheniramine maleate Dimetapp; DMT; Hisdec; Nasatapp; Nosterot; Pediatapp; Pen ProprietaryPreparations (details are given in Volume B) may be given orally to children, for the symptomatic relief brosol; PPB; Remedril; Rhinodec; Rhinotapp; Snizee; Solvamin; of allergic conditions such as rhinitis and conjunctivitis; Zeditapp; Pol.: Disophrolt; NeoAfrin; Port.: Constipalt; Ilvico Multi-ingredient Preparations. USA: Ambenyl Cough Syrupt; doses are as follows: N; S.Afr. : Dimetappt; Ilvicot; Singapore: Dimetapp; Rinafort; Amgenal Caught; Bromotuss with Codeinet. • children aged 2 to 6 years: mg every four to six hours Spain: Disofrol; Ilvico; Swed.: Disofrolt; Switz.: Disofrolt; Aorinyl; Asiatapp; Bepeno-G; Bepeno; Bluco; Broma� • those aged 6 to 12 years: 2 mgI every four to six hours Thai.: PharmacopoeialPreparations those aged over 12 years: 4 mg every four to six hours vont; Bromceryl; Bromesep Elixir; Bromesep Expectorant; Bro USP 36: Bromodiphenhydramine Hydrochloride and Codeine • Bromphenirarnine maleate is a common ingredient of mesep Syrup; Bromiphed; Bromlamine; Bromped; Bromsuno; Phosphate Oral Solution; Bromodiphenhydramine Hydro compound preparations for the symptomatic treatment of Bromtussia DCt; Bromtussia; Brontus; Centapp; Chintacold; chloride Elixir. Cold-tab; Coldate; Cotapp Expectorant; Cotapp; Daminate; coughs and the common cold. However, such preparations Decon; Dimetapp; Ditap; Leffrin; Meditapp Expectorantt; Medi should be used with caution in children, and generally tapp; MEXY; Minra; Nartap; Nased; Nasorest Expectorant; 614.1. avoided in young children, for details see p. Nasorest; Nasotane; Nasotapp; Pharcold; Pharfed; Phemine; Brompheniramine Maleate Polamine; Polydine; Polydrop; Postap Expectorantt; Postapt; (BANM, r/NNM) Adverse Effects and Precautions Rhinadinet; Sinufen; St Luke's Cold; Topamine; Unihist; Turk.: · Disophrol; UK: Dimotane Co; Dimotane Expectorant; USA: 12 As for the sedating antihistamines in general, p. 613.1 and !lromfeniramin Male'lt: Bromf�nirarnina,.. ·· miJI�at; Hour Antihistamine Nasal Decongestant; 12 Hour Cold; Accuh de! 613.3, 8(6mfeqirim1in,maleat; Bromfen.lramil'lm�lea):;•. f1rornf�nira· p. respectively. ist DM Pediatric; Accuhist PDXt; Alacol DMt; Alahist DM; o mlrrma!