The four hypoxia gene lists together with fold-change (Log2-transformed) of expression after hypoxia treatment in the cervical cancer cell lines HeLa, SiHa, and CaSki

Hypoxia cervical up x3 Hypoxia cervical up & literature Hypoxia cervical down x3 Hypoxia cervical down & literature

GeneSymbol HeLa SiHa CaSki GeneSymbol HeLa SiHa CaSki ABCA7 2.347 2.008 1.036 MLKL -1.298 -1.500 -1.089 ARID3A 1.369 3.040 1.256 NOL6 -2.084 -1.305 -1.543 C1ORF51 1.240 2.139 1.591 NOP2 -1.525 -1.531 -1.060 HIG2 2.781 2.185 2.158 PRMT3 -1.216 -1.084 -1.431 CMIP 1.190 1.003 1.130 ELOVL6 -1.743 -1.557 -1.490 FGF11 1.752 3.849 2.682 HSPH1 -1.796 -1.255 -1.002 FTH1P3 1.135 1.490 1.033 KIAA0020 -1.100 -1.184 -1.148 GPRC5C 1.011 4.025 1.307 LRP8 -1.099 -1.529 -1.248 HSF2BP 1.647 1.020 1.049 ODC1 -1.393 -1.578 -1.796 IRS2 1.552 1.128 1.352 VARS -1.772 -1.076 -1.125 LOC100008589 1.992 2.096 1.120 ABCF2 -1.129 -0.807 -0.725 LOC286016 2.431 1.532 1.232 ACOT7 0.125 -1.300 -0.933 LOC401152 2.016 2.262 1.810 ADAR -1.619 -0.198 -0.102 LOC441763 2.646 2.047 1.127 AIMP2 0.209 -1.330 -0.881 LOC644760 2.284 1.428 1.375 AMD1 -1.484 -0.639 -0.469 LOC644774 1.328 2.036 1.871 ANLN -1.210 -1.560 0.561 LOC645553 2.282 1.658 1.581 ATIC -1.036 -0.738 -0.834 LOC730525 1.548 1.646 1.668 ATP5G1 0.631 -1.445 -1.243 LOC732165 2.843 1.861 1.251 BCS1L -0.075 -1.010 -0.540 MALL 1.368 2.180 1.089 BOP1 -1.145 -0.863 -0.916 NMB 1.868 1.265 1.724 BRCA1 -0.006 -1.101 0.211 NUDT18 1.845 1.444 1.208 C12ORF48 -0.985 -1.219 -0.163 PGAM4 1.674 1.434 1.006 C17ORF80 -1.277 -0.462 -0.183 PIK3IP1 1.100 1.421 1.477 C1ORF135 0.187 -1.500 -0.493 SLPI 2.428 1.183 1.230 C1ORF163 -0.086 -1.042 -0.894 TMEM145 1.029 2.401 1.514 C20ORF27 0.405 -1.387 -0.368 TMEM158 1.044 1.249 1.238 CAD -0.761 -1.093 -0.449 TNNT1 1.835 1.628 1.107 CALD1 -1.040 0.595 0.297 VKORC1 2.453 1.792 1.373 CALM1 -1.207 0.078 0.015 ADM 2.973 2.359 1.489 CAPRIN1 -1.580 -0.417 -0.432 AK3L1 2.063 2.590 1.208 CBX6 -1.918 -0.278 -0.426 ALDOA 1.690 1.475 1.132 CCDC86 -0.680 -0.405 -1.109 ALDOC 4.288 3.918 1.793 CCDC99 -0.432 -1.171 -0.089 ANG 3.058 2.225 2.283 CCNA2 -0.759 -2.159 -0.416 ANKRD37 3.809 3.731 2.380 CCND1 -2.287 -0.046 -1.584 ANKZF1 1.881 1.781 1.406 CCND3 -1.286 -1.117 -0.457 BHLHB2 1.010 1.540 1.752 CCNF -1.695 -1.787 -0.168 BNIP3 3.299 3.392 2.598 CCT6A -1.337 -0.755 -0.723 BNIP3L 2.044 3.613 2.839 CDC2 0.064 -1.654 -0.063 BTG1 1.754 1.455 1.556 CDC20 -0.958 -2.065 -0.514 CA9 5.977 6.104 4.825 CDCA4 0.908 -1.040 0.070

Cervix cancer hypoxia gene sets p1 CCNG2 1.247 1.252 1.149 CENPF -1.248 -1.798 0.016 CDKN1A 1.109 1.595 1.043 CENPN 0.917 -1.019 -0.002 DDIT4 1.750 2.234 3.578 CNOT7 -1.130 0.122 0.031 EGLN1 1.484 1.323 1.307 COL18A1 -1.254 0.106 0.117 EGLN3 1.561 2.161 1.388 CORO1C -1.019 0.396 -0.122 ENO2 2.870 2.553 2.797 CSDE1 -1.096 -0.145 -0.429 ERRFI1 2.967 1.389 2.106 CSE1L -1.255 -1.115 -0.763 FAM162A 2.850 2.294 2.033 CTPS -0.962 -1.048 -0.897 GAPDH 1.072 1.277 1.072 CYTSA -1.050 0.120 0.364 GPI 1.627 1.427 1.374 DDX23 -1.297 -0.695 -0.305 HCFC1R1 2.269 1.333 1.082 DDX3X -1.320 0.261 0.206 HK2 1.782 3.158 1.346 DHCR24 -1.102 -0.517 -0.323 IGFBP3 3.043 3.780 2.288 DHX29 -1.190 -0.536 -0.533 INSIG2 1.831 2.272 2.012 DLAT -1.222 -0.123 -0.482 JMJD1A 1.064 1.763 1.592 EEF2 -1.349 0.669 0.305 KCTD11 1.244 1.842 1.925 EFEMP1 -1.215 -0.783 -0.609 LOX 1.890 4.247 2.822 EFTUD2 -1.033 -0.505 -0.446 MUC1 1.335 2.392 2.193 ERCC6L -0.576 -1.556 -0.357 NDRG1 3.436 3.424 3.953 EXO1 -0.290 -2.210 -0.193 P4HA1 1.870 2.587 2.051 FANCG -0.260 -1.046 -0.127 P4HA2 1.840 2.805 1.544 FANCI -1.087 -1.405 0.175 PFKFB4 2.657 3.671 3.575 FASN -1.587 -0.899 -0.930 PGAM1 1.422 1.527 1.128 FASTKD5 -1.196 -0.539 -0.489 PGK1 1.444 1.986 1.867 FBXO5 0.093 -1.301 0.182 PLOD2 1.456 2.232 2.103 FEN1 0.316 -1.146 -0.151 PPFIA4 2.129 2.214 1.783 FGF2 -1.315 0.002 -0.179 PTPRR 1.281 1.040 1.325 GART -0.728 -1.122 -0.666 RNASE4 2.273 2.595 2.358 GINS3 0.101 -1.234 -0.046 RNF24 1.143 1.574 1.094 GLRX2 0.586 -1.086 -0.081 SH3GL3 1.747 2.739 1.548 GMFB -1.598 -0.047 0.058 SPRY1 1.996 2.727 2.146 GNA13 -1.044 0.237 0.341 STC2 2.540 4.348 2.824 GNPDA1 -1.011 -0.348 -0.765 TMEM45A 3.846 3.741 2.560 GPD1L -1.423 -0.761 -0.754 TPI1 1.617 1.254 1.016 GPR56 -1.196 -0.299 -0.211 VLDLR 1.869 2.711 1.762 GULP1 -1.058 -0.236 -0.196 WDR54 2.383 1.816 1.126 H2AFX 0.771 -1.253 -0.021 YPEL5 1.146 1.687 1.374 HEATR1 -1.799 -0.753 -0.503 ZNF395 2.073 2.886 1.569 HIF1A -1.006 0.596 0.146 ABCA1 -0.566 1.133 1.038 HJURP 0.120 -1.879 -0.078 ABCB6 0.513 1.258 0.975 HMBS 0.457 -1.329 -0.659 ADORA2B 1.560 1.459 -0.602 HSPA1A -1.351 -0.459 -0.610 AK2 1.090 0.429 0.122 HSPA1B -1.255 -0.478 -0.393 ANGPTL4 0.776 3.486 3.613 HSPA4 -1.137 -0.197 -0.328 ANKRD9 1.323 0.985 0.218 HSPC111 0.522 -1.183 -1.208 AOX1 0.728 1.718 -0.006 HSPD1 -1.005 -0.604 -0.761 APITD1 1.096 -0.691 -0.139 HSPE1 -0.209 -0.650 -1.042 ARRDC3 0.009 1.491 1.208 IARS -1.211 -0.657 0.210 ATF3 0.906 0.413 1.158 IDE -1.688 -0.756 -0.574 ATP1B1 1.084 1.413 0.098 IDH3A -1.135 -0.246 -0.920 ATP5O 1.132 -0.005 0.026 KIF23 -1.138 -1.985 -0.259

Cervix cancer hypoxia gene sets p2 AXL -0.567 1.397 0.282 KIF4A -0.425 -1.507 0.195 B3GNT4 0.338 1.955 0.305 KIAA0101 0.967 -1.571 -0.016 BAX 1.735 -0.341 0.300 KIAA0564 -1.168 -0.249 -0.024 BIK 0.651 1.866 1.428 KPNA4 -1.243 -0.268 -0.209 BLVRB 1.053 0.049 0.395 LARP4 -1.457 -0.185 -0.342 BOLA2 1.497 -0.647 -0.404 LARS2 -1.173 -0.350 -0.321 C10ORF10 -0.038 0.142 1.493 LDLR -1.288 -1.117 -0.527 C12ORF24 1.243 1.066 -0.122 LETM1 -1.272 -0.711 -0.283 C14ORF2 1.088 -0.073 -0.307 MAD2L1 0.132 -1.428 -0.372 C16ORF74 1.218 1.213 0.157 MCL1 -1.098 -0.925 -0.564 C19ORF53 1.285 -0.399 -0.252 MCM10 0.290 -1.317 0.082 C3ORF10 1.503 1.172 0.514 MELK 0.047 -1.760 0.152 C5ORF13 0.334 1.683 0.655 MEST -1.412 -0.344 -1.058 CA12 1.678 3.304 0.067 MNS1 0.403 -1.627 -0.342 CAV1 0.841 1.166 0.571 MPHOSPH9 -1.160 -1.078 -0.184 CD99 1.715 0.817 0.275 MRTO4 0.337 -0.766 -1.027 CDC2L6 -0.068 1.102 0.968 NARS -1.019 -0.554 -0.062 CDKN1C 2.384 0.260 0.569 NAT10 -1.292 0.384 -0.703 CEBPB -0.101 0.026 1.001 NCAPG2 -0.380 -1.386 0.149 CEBPD 1.443 0.538 -0.132 NFKB1 -1.400 -0.366 -0.056 CECR5 0.929 1.015 0.189 NME1 0.496 -0.794 -1.216 CFD 2.469 0.979 0.227 NMT1 -1.732 0.027 -0.234 CHSY1 -0.233 1.734 0.291 NOL11 -1.415 -0.646 -0.621 CITED2 1.169 1.802 0.705 NOL12 0.073 -1.151 -0.245 CKB 1.890 0.588 0.008 NOLC1 -1.484 -1.202 -0.683 CNOT8 0.670 1.084 0.522 NOP56 -0.055 -1.156 -0.896 COL5A1 -0.435 1.433 1.274 NUP160 -1.471 -0.682 -0.277 CRLF1 1.139 0.325 -0.179 NUP205 -1.094 -0.659 -0.373 CSNK2B 1.350 -0.076 0.041 NUP85 -0.195 -1.014 -0.050 CSRP2 1.666 0.831 0.877 NUSAP1 -0.421 -1.484 0.059 CXCR4 1.263 -0.103 -0.226 OIP5 0.708 -1.344 -0.251 CXCR7 0.862 1.242 0.019 ORC6L 0.491 -1.937 -0.195 CYB5A 1.006 -0.386 -0.263 PA2G4 0.537 -1.312 -0.524 DDIT3 1.510 0.383 1.210 PARP1 -1.243 -0.107 -0.436 DDX41 0.771 1.371 0.448 PARP2 0.079 -1.158 -0.138 DPM2 1.172 -0.236 -0.081 PBK -0.062 -1.564 -0.500 DPYSL2 0.402 0.634 1.053 PCYT2 -0.138 -1.118 -0.410 DPYSL4 -0.368 2.636 -0.001 PER3 -0.558 -1.166 -0.007 DUSP1 0.912 1.460 0.351 PFAS -1.751 -0.950 -0.896 EBP 1.232 -0.958 0.128 PKMYT1 0.817 -2.080 0.241 EBPL 1.350 0.483 -0.352 POLA2 -0.547 -1.209 -0.064 ECE2 1.042 0.292 -0.382 POLE2 0.201 -1.336 -0.409 EDN2 3.570 4.209 0.234 PPARG -0.776 -1.137 -1.003 EFNA1 0.979 1.167 0.199 PPAT -1.019 -0.274 -0.728 EIF1B 1.146 -0.204 -0.007 PRC1 -0.925 -2.004 0.037 ELF3 0.644 1.000 0.234 PSMC3IP 0.968 -1.311 -0.051 ELL2 -0.211 1.121 0.347 PSME3 -1.137 -0.291 -0.746 EMP3 1.520 0.523 0.130 PSME4 -1.482 -0.209 -0.411 EPOR 1.192 0.579 0.195 PSMG1 0.414 -1.022 -0.234 ERO1L 0.366 1.651 1.200 RAD51AP1 -0.175 -1.706 0.160

Cervix cancer hypoxia gene sets p3 EXOSC8 1.014 -0.851 0.010 RAI14 -1.110 -0.506 -0.564 FABP5 1.064 -0.677 -0.571 RANBP1 0.483 -1.052 -0.555 FAM119B 0.455 2.121 0.188 RANGAP1 -1.780 -1.127 -0.093 FAM13A 0.477 1.480 0.405 RBM12 -1.059 -0.525 -0.595 FAM46A -0.150 0.863 1.220 RFC3 -0.610 -1.683 -0.449 FER1L4 -0.342 1.610 -0.702 RFC5 0.099 -1.121 -0.208 FLNB 0.336 0.889 1.217 RNF14 -1.102 -0.035 0.054 FOS -0.885 1.942 -0.125 RPP40 0.377 -1.140 -1.085 FOXD1 1.943 1.495 0.117 RRM1 -0.622 -1.108 -0.228 FOXO3 0.077 1.109 0.200 RRM2 -0.206 -2.346 -0.141 GADD45B 1.261 0.867 0.701 RRP1B -1.065 0.003 -0.282 GBE1 0.914 2.877 1.318 RRP9 -0.423 -0.799 -1.240 GLRX 1.662 1.357 0.792 RRS1 -0.136 -1.356 -1.362 GLS -0.019 1.196 0.402 SCD -1.111 0.357 0.555 GPRC5A 1.506 1.491 0.762 SEH1L -1.198 -0.338 -0.473 GRSF1 -0.572 1.387 0.104 SEL1L3 -1.208 -0.360 0.279 GYS1 0.988 1.636 0.751 SFRS1 -1.127 -0.649 -0.477 HBP1 0.450 1.129 0.793 SIP1 0.236 -1.039 -0.523 HERC3 0.400 1.098 0.483 SKP2 -0.960 -1.096 -1.221 HERPUD1 1.091 0.650 0.996 SLC11A2 -1.308 0.056 -0.553 HLA-B 1.698 1.426 0.340 SLC25A44 -1.506 -0.335 -0.162 HLA-DQB1 0.023 3.361 0.180 SLC5A6 -1.374 -1.096 -0.822 HLA-DRB1 0.183 2.991 -0.030 SQLE -0.603 -1.022 -0.209 HMHA1 -0.254 1.168 0.880 SRM 0.339 -0.793 -1.180 HMOX1 0.906 1.092 1.799 STIL -1.009 -1.678 0.169 HOMER1 -0.334 1.193 -0.080 TFRC -1.022 0.889 -0.568 HSPA5 -0.478 1.610 -0.014 THBS1 -1.017 0.369 -0.129 ID1 1.720 0.294 -0.424 TIPIN 0.079 -0.888 -1.095 ID2 1.955 0.309 0.528 TMTC3 -1.577 -0.162 -0.211 IDH2 1.901 0.384 0.608 TPX2 -1.318 -2.036 0.195 IER3 2.286 2.491 0.987 TRIOBP 0.040 -1.082 -0.213 IGFBP2 1.066 -0.114 0.108 TRIP13 -0.193 -1.838 -0.554 IGFBP5 1.111 2.282 -0.673 TRMT5 0.064 -1.216 -0.230 IGFBP7 1.311 0.253 0.408 TSEN2 -1.032 -0.775 -1.046 ILVBL 0.189 1.214 0.709 TUBB2C 0.240 -1.179 -0.138 IMMP2L 1.278 0.839 -0.101 TUBG1 0.434 -1.208 -0.149 IMP3 1.238 0.774 0.473 TUBGCP4 -1.057 -0.406 -0.497 INHBE 1.329 0.061 0.094 VWF -1.155 0.167 -0.102 ISG15 1.270 -0.187 -0.488 WDR12 -0.250 -1.081 -1.057 ISG20 2.789 2.035 0.886 WDR4 -0.468 -1.340 -0.615 ITGA5 1.323 2.870 0.773 XPO5 -1.154 -0.238 -0.119 ITGB4 0.471 1.338 0.918 XRCC5 -1.048 -0.441 -0.425 JMJD6 1.062 0.559 0.151 ZMPSTE24 -1.495 -0.299 -0.239 JUN 1.422 2.776 0.705 ZWILCH -1.302 -0.824 -0.087 JUNB 1.903 1.183 0.444 ZWINT 0.406 -2.132 -0.286 KIAA1199 -0.204 -0.041 2.386 AASDHPPT -1.088 0.166 -0.504 KLF4 0.198 0.838 1.245 KLF6 1.038 0.249 0.912 KLHL24 0.372 1.015 1.583 LARP6 1.859 0.611 0.275

Cervix cancer hypoxia gene sets p4 LGALS1 1.309 0.928 0.601 LIMCH1 -0.652 1.035 0.439 MAFF 0.875 1.763 0.826 MAZ 1.098 -0.066 0.104 MDK 1.379 0.542 0.093 MED10 1.114 -0.035 0.189 MEF2A 0.084 1.601 0.024 MIF 1.429 0.946 0.433 MOBKL2A 0.457 1.327 0.962 MPI 1.030 2.023 0.716 MRPL14 1.292 -0.243 -0.144 MRPL40 1.050 -0.374 -0.357 MT2A 1.758 0.523 -0.015 MXI1 0.843 1.860 0.434 NARF 1.210 1.000 0.661 NEK6 0.067 1.154 0.263 NFIL3 0.869 1.346 0.945 NINJ2 1.038 0.350 0.225 NME1 1.006 -0.901 -0.949 NMU 1.105 -0.794 0.037 NOL3 1.227 2.138 0.551 NUAK1 0.064 0.841 1.108 NUPR1 1.203 0.441 0.031 ORAI3 0.398 1.250 0.556 OSMR 0.411 1.171 0.714 PAM 0.328 2.259 1.596 PARVB 1.207 -0.087 -0.025 PDK3 1.603 1.184 0.861 PELI2 -0.877 1.022 -0.012 PET112L -0.084 1.001 -0.192 PFKFB3 0.536 2.980 1.461 PFKL 0.909 0.982 1.255 PFKP 0.897 2.568 0.887 PIM1 0.964 1.026 1.062 PIM2 0.757 1.553 0.136 PKM2 1.761 1.194 0.662 PLAC8 1.765 -0.473 1.945 PLAUR 1.752 0.690 0.281 PLEK2 1.095 -0.484 -0.102 PLIN2 0.943 2.812 0.035 PLOD1 0.017 0.974 1.091 PPP1R13L 0.593 1.362 0.481 PPP1R3C 1.367 0.027 0.011 PTGS1 0.025 3.560 -0.056 PTGS2 0.089 1.311 0.667 PTMS 1.892 -0.199 0.664 PTPRF 0.386 1.398 0.825 PYGL -0.199 1.983 0.568 QSOX1 0.310 1.108 0.376 RAB20 1.775 1.810 0.675

Cervix cancer hypoxia gene sets p5 RAB40C 0.801 1.146 0.474 RALGDS -0.643 1.116 1.179 RASSF2 -0.346 1.091 0.022 RHOC 1.053 0.118 0.077 RIOK3 0.396 1.431 0.753 RIPK4 0.354 1.068 0.043 RLF 0.218 1.049 0.516 RORA 0.936 0.977 1.818 RP11-529I10.4 2.049 1.723 0.291 RPL17 1.157 0.144 -0.036 RPL36A 1.241 -0.475 -0.522 RPL39L 1.425 -0.730 -0.217 RPS27 1.009 0.389 0.546 RPS29 2.514 1.200 0.947 RRAGA 1.203 1.632 0.435 RRAGD 1.524 2.143 -0.094 RRAS 1.705 0.835 0.853 S100A10 1.841 0.622 0.171 S100A2 1.119 0.158 -0.450 S100A6 1.000 0.155 0.639 SAP30 1.554 0.749 1.036 SCARB1 0.350 1.288 -0.021 SEMA4B 0.340 1.538 0.954 SEPW1 1.086 0.105 0.009 SERGEF 1.570 1.106 0.614 SERPINB2 -0.006 1.154 -0.859 SERPINE1 1.667 2.134 0.983 SERTAD2 0.196 1.142 0.829 SFRS9 1.107 -0.123 0.186 SH3BGRL3 2.182 0.722 0.618 SIRPA 0.051 1.018 0.055 SLC16A3 0.585 1.465 1.525 SLC2A1 0.621 1.922 1.198 SLC2A14 2.491 0.303 0.110 SLC2A3 2.853 0.746 0.966 SLC35E1 0.442 1.633 0.625 SLC6A8 0.695 1.160 1.009 SLCO4A1 0.084 1.550 1.363 SNTA1 1.402 1.430 0.638 SOD2 1.146 -0.236 0.116 SOX4 0.516 1.225 0.636 SPAG4 0.404 2.546 1.057 SPAG7 1.203 -0.167 0.082 SSR4 1.713 0.476 0.106 STC1 0.988 3.612 0.067 STRA13 1.245 -0.467 -0.049 SYF2 1.119 0.092 0.306 SYT7 0.963 2.888 0.793 TAGLN 1.475 0.248 -0.286 TCEAL1 1.016 0.394 -0.024

Cervix cancer hypoxia gene sets p6 TGFBI -0.093 4.102 0.286 TH 0.449 0.038 1.197 TIMP2 1.467 0.599 0.200 TMEM4 1.247 0.089 0.205 TNFAIP8 0.578 1.464 1.643 TPD52 0.191 1.369 0.803 TPT1 1.558 0.501 0.518 TRAPPC1 1.520 -0.015 0.226 TSKU 0.556 1.263 0.106 TSR1 -0.174 1.462 -0.060 TXNIP 1.279 0.840 1.538 UBE2E1 0.175 1.538 0.085 UGP2 1.010 1.661 0.830 UPK1A 2.248 5.012 0.035 UQCRH 1.109 -0.144 -0.273 VEGFA 0.998 2.378 1.151 VEGFB 1.273 0.921 0.531 WISP2 3.545 1.356 0.149 WSB1 0.602 1.329 1.086 YEATS2 0.537 1.391 0.822 YPEL1 -0.113 1.006 0.186 ZNF32 1.152 0.230 -0.050 ZNF654 -0.217 1.000 0.468

Cervix cancer hypoxia gene sets p7 Gene sets from published literature or from the KEGG or Reactome pathway data bases

1 STARMANS_WOUND_SIGNATURE 2 STARMANS_PROLIFERATION_SIGNATURE 3 CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 4 ISHIGAMI_RADIATION_RESISTANCE 5 AMUNDSON_GAMMA_RADIATION_RESISTANCE 6 WINTER_HYPOXIA_UP 7 MENSE_HYPOXIA_UP 8 REACTOME_CELL_CYCLE_CHECKPOINTS 9 KEGG_BASE_EXCISION_REPAIR 10 KEGG_HOMOLOGOUS_RECOMBINATION 11 KEGG_NON_HOMOLOGOUS_END_JOINING 12 KEGG_PROTEIN_PROCESSING_IN_ER

1 23456 7 8 9 101112 STARMANS_WO STARMANS_ CHIANG_LIVEISHIGAMI_RAAMUNDSON_WINTER_HYPOMENSE_HYPO REACTOME_C KEGG_BASE_EKEGG_HOMOKEGG_NON_HKEGG_PROT na na na na na na na na na na na na AADACL1 ABCC5 ABCC1 PTHLH F11 ADORA2B ABCB6 ANAPC1 APEX1 BLM DCLRE1C AMFR ABHD14B ANLN AFP ID1 TSPAN7 AK3L1 ABCB7 ANAPC10 APEX2 BRCA2 DNTT ATF4 ACIN1 ASF1B ANLN ID3 BDKRB1 ALDOA ABCB8 ANAPC11 FEN1 EME1 FEN1 ATF6 ACSL3 AURKA ARHGAP18 FGFR3 CD40 ANGPTL4 ABCB9 ANAPC2 HMGB1 MRE11A LIG4 ATXN3 ACSS2 BIRC5 ARID3A VAV3 XRCC1 ANKRD37 ABCB10 ANAPC4 LIG1 MUS81 MRE11A ATXN3L ACTL6A BUB1 ASPM PTGS2 PSG11 ANKRD9 ABCB11 ANAPC5 LIG3 NBN NHEJ1 BAG1 ADAMTS1 BUB1B ASRGL1 PLD1 CCL7 ANLN ABCB12 ANAPC7 MBD4 POLD1 POLL BAK1 ADCY3 BUB3 ATP1A1 JAG1 EDNRA B4GALT2 ABCB13 ATM MPG POLD3 POLM BAX ADD3 C11ORF82 AURKB FGFBP1 C1QB BCAR1 ABCB14 ATR MUTYH POLD4 PRKDC BCAP31 ALKBH7 C13ORF3 B3GNT5 PEG10 CHGA BMS1 ABCB15 ATRIP NEIL1 RAD50 RAD50 BCL2 ANKDD1A CASP3 B4GALT5 S100P CBLB BNIP3 ABCB16 BUB1B NEIL2 RAD51 XRCC4 C2ORF30 ANKRD12 CCDC99 BACE2 ICAM2 TNFSF13B C14ORF156 ABCB17 BUB3 NEIL3 RAD51C XRCC5 CALR ANKRD32 CCNA2 BARD1 MMP13 CRMP1 C16ORF68 ABCB18 CCNB1 NTHL1 RAD51L1 XRCC6 CANX APITD1 CCNB2 BCAT1 MME SLC22A4 C16ORF74 ABCB19 CCNB2 OGG1 RAD51L3 CAPN1 APOD CCNF BIRC5 SNCA ELA2A C20ORF20 ABCB20 CCNE1 PARP1 RAD52 CAPN2 APP CDC2 BUB1B TNFSF10 COL11A2 CA12 ABCB21 CCNE2 PARP2 RAD54B CKAP4 ARHGAP12 CDC25C C4ORF7 PLAGL1 TUBA1B CA9 ABCB22 CDC16 PARP3 RAD54L CREBL1 ARHGEF3 CDCA5 CCNA2 SERPINB5 CDCA4 ABCB23 CDC2 PARP4 RPA1 CRYAB ARID5B CDCA8 CCNB1 TIMP3 CEP27 ABCB24 CDC20 PCNA RPA2 CRYAA ARMCX3 CDKL5 CCNB2 FBLN1 CNIH4 ABCB25 CDC23 POLB RPA3 CUL1 ARSD CENPA CCNE1 RUNX3 COL4A5 ABCB26 CDC25A POLD1 RPA4 DAD1 ATP6V0A1 CENPF CD24 DAB2 CORO1C ABCB27 CDC25C POLD3 SHFM1 DDIT3 AZI2 CENPM CDC20 SYK DPM2 ABCB28 CDC26 POLD4 SSBP1 DDOST BBC3 CENPQ CDC6 ROBO1 ECE2 ABCB29 CDC27 POLE TOP3A DERL1 BCCIP CIITA CDC7 PVRL3 EIF2S1 ABCB30 CDC45L POLE2 TOP3B DERL2 BCL6 CKAP2 CDCA5 GAPDH ABCB31 CDC6 POLE3 XRCC2 DERL3 BDH2 CKAP2L CDCA7 GMFB ABCB32 CDC7 POLE4 XRCC3 DNAJA1 BHLHB2 CKS1B CDCA7L GSS ABCB33 CDK2 POLL DNAJA2 BRCA2 CKS2 CDKN3 HES2 ABCB34 CDKN1A SMUG1 DNAJB1 BRF2 CSNK1G1 CENPE HIG2 ABCB35 CHEK1 TDG DNAJB11 BRIP1 DEPDC1B CENPF HOMER1 ABCB36 CHEK2 UNG DNAJB12 C10ORF10 DHFR CHST11 IGF2BP2 ABCB37 CLSPN XRCC1 DNAJB2 C10ORF26 DLG7 CKAP4 IL8 ABCB38 DBF4 DNAJC1 C10ORF33 DONSON CSDA KCTD11 ABCB39 HUS1 DNAJC10 C11ORF24 EFHC1 CTBP2 KRT17 ABCB40 MAD1L1 DNAJC3 C12ORF24 ESCO2 CYBA LDHA ABCB41 MAD2L1 DNAJC5 C13ORF1 EXO1 DBN1 LDLR ABCB42 MCM10 DNAJC5B C13ORF27 EZH2 DDR1 METTL11A ABCB43 MCM2 DNAJC5G C16ORF61 FAM64A DEPDC1 MIF ABCB44 MCM3 EDEM1 C17ORF58 FAM83D DEPDC1B MNAT1 ABCB45 MCM4 EDEM2 C18ORF24 FANCA DTL MRPL14 ABCB46 MCM5 EDEM3 C19ORF48 FANCI DUSP9 MTX1 ABCB47 MCM6 EIF2AK1

Remaining gene sets p1 C1ORF198 FEN1 E2F8 NDRG1 ABCB48 MCM7 EIF2AK2 C1ORF41 FOXM1 ECT2 NDUFA4L2 ABCB49 MCM8 EIF2AK3 C1RL GAS2L3 ELF4 NME1 ABCB50 MDM2 EIF2AK4 C1S GTSE1 ELOVL7 NUDT15 ABCB51 ORC1L EIF2S1 C3ORF26 H2AFX ETV4 P4HA1 ABCB52 ORC2L ERN1 C4ORF18 HIST1H2AC EZH2 PDZD11 ABCB53 ORC3L ERO1L C5ORF4 HJURP FBXO5 PFKFB4 ABCB54 ORC4L ERO1LB C6ORF173 HMMR FEN1 PGAM1 ABCB55 ORC5L ERP29 C8ORF13 HN1 FHOD3 PGF ABCB56 ORC6L FBXO2 CALCOCO1 KIAA1333 FMNL2 PGK1 ABCB57 PSMA1 FBXO6 CBLN3 KIAA1370 FOXM1 PLAU ABCB58 PSMA2 GANAB CBX1 KIF20B FUNDC1 PLEKHG3 ABCB59 PSMA3 GCS1 CCDC5 KIF23 G6PD PPARD ABCB60 PSMA4 HERPUD1 CCNL2 KIFC1 GALNT7 PPP4R1 ABCB61 PSMA5 HSP90AB1 CCPG1 LMNB1 GLIS2 PSMA7 ABCB62 PSMA6 HSP90B1 CCT5 LOC441052 GPD1L PSMB7 ABCB63 PSMA7 HSP90AA1 CD46 LOC653820 H19 PSMD2 ABCB64 PSMB1 HSPA1A CD82 MAD2L1 HDAC2 PTGFRN ABCB65 PSMB10 HSPA1B CDC14B MAPK13 HIST1H4C PVR ABCB66 PSMB2 HSPA1L CDC2L2 MELK HK2 PYGL ABCB67 PSMB3 HSPA2 CDCA4 MET HMGB2 RAN ABCB68 PSMB4 HSPA4L CDK2 MLF1IP HN1 RHOC ABCB69 PSMB5 HSPA5 CDKN1A MND1 KIF11 RNF24 ABCB70 PSMB6 HSPA6 CDKN1C NCAPD3 KIF14 RNPS1 ABCB71 PSMB7 HSPA8 CENPJ NCAPH KIF20A RUVBL2 ABCB72 PSMB8 HSPBP1 CENPN NLRP2 KIF23 S100A10 ABCB73 PSMB9 HSPH1 CFB NUF2 KIF2C S100A3 ABCB74 PSMC1 HYOU1 CHEK1 NUSAP1 KIF4A SIP1 ABCB75 PSMC2 LMAN1 CKLF PHTF2 LAMB1 SLC16A1 ABCB76 PSMC3 LMAN1L CLCF1 PLK1 LHFPL2 SLC2A1 ABCB77 PSMC4 LMAN2 CLCN6 PRIM1 LMNB1 SLC6A8 ABCB78 PSMC5 MAN1A1 CLIC2 PRIM2A LRRC1 SLCO1B3 ABCB79 PSMC6 MAN1A2 CNTNAP1 PRR11 MAD2L1 SNX24 ABCB80 PSMD1 MAN1B1 COPB2 PSRC1 MAPK13 TEAD4 ABCB81 PSMD10 MAN1C1 COPS6 PWP1 MARCKS TFAP2C ABCB82 PSMD11 MAP2K7 COQ2 RAD51AP1 MARCKSL1 TMEM30B ABCB83 PSMD12 MAP3K5 COTL1 RANGAP1 MCM2 TMTC3 ABCB84 PSMD13 MAPK10 COX17 RFC2 MEP1A TNS4 ABCB85 PSMD14 MAPK8 CPM RFC4 MKI67 TPD52L2 ABCB86 PSMD2 MAPK9 CRTAP RRM1 MMD TPI1 ABCB87 PSMD3 MBTPS1 CST3 RRM2 MMP12 TRMT5 ABCB88 PSMD4 MBTPS2 CTNS SMC4 MMP9 TUBB2C ABCB89 PSMD5 NFE2L2 CTSF SPAG5 MTMR2 VAPB ABCB90 PSMD6 NGLY1 CYBRD1 TACC3 NCK2 VEGFA ABCB91 PSMD7 NPLOC4 CYP27A1 TIMP1 NEK2 VEZT ABCB92 PSMD8 NSFL1C CYP4V2 TOP2A NUSAP1 XPO5 ABCB93 PSMD9 OS9 DAB2 TPX2 OIP5 SLC6A1 ABCB94 PSME1 P4HB DBNDD1 TRIP13 ORC6L ZNF713 ABCB95 PSME2 PARK2 DCBLD2 TSN PAFAH1B3 UBE2V1 ABCB96 PSME3 PDIA3 DCK TUBA4A PAG1 ABCB97 PSMF1 PDIA4 DCLRE1B TUBB PAPLN ABCB98 RAD1 PDIA6 DDIT3 TUBB2B PBK ABCB99 RAD17 PLAA DHFR TUBB2C PDE9A ABCB100 RAD9A PPP1R15A DLEU1 TYMS PKM2 RAD9B PREB DNAJC21 UBE2C PLP2 RFC2 PRKCSH DNAJC9 UBE2T PNMA1 RFC3 RAD23A DNM1 USP1 PRC1 RFC4 RAD23B DPP7 WDR51A PRKCD RFC5 RBX1 DPYSL2 WSB1 PTP4A3 RFWD2 RNF185 DTYMK YWHAH PTTG1 RPA1 RNF5 DUSP22 ZNF587 RACGAP1 RPA2 RPN1 DUT ZNHIT2 RAD51AP1 RPA3 RPN2 DYNLT1 RFC4 TP53 RRBP1 EBNA1BP2 S100P UBB SAR1A ECHDC2 SALL4 UBE2C SAR1B EEF1E1 SC65 UBE2D1 SEC23A EIF4E3 SELM UBE2E1 SEC23B

Remaining gene sets p2 EIF4EBP1 SGOL2 WEE1 SEC24A EIF4G1 SHCBP1 SEC24B EMP2 SLAMF8 SEC24C ENO1 SLC16A3 SEC24D EPHB1 SLC1A5 SEC31A ERLIN1 SLC38A1 SEC31B ERRFI1 SLC39A10 SEC61A1 ETV1 SLC7A7 SEC61A2 EXOSC8 SOX4 SEC61B F10 SOX9 SEC61G F3 SPHK1 SEC62 FABP3 SYNJ2 SEC63 FABP5 TMED3 SEL1L FADS1 TMEM51 SELS FADS2 TMEM65 SIL1 FAM171B TNFRSF21 SKP1A FAM33A TOP2A SSR1 FAM62B TPX2 SSR2 FAM89B TRIP13 SSR3 FARSA TTF2 SSR4 FARSLB TTK STT3A FCGRT UBE2C STT3B FDPS UGCG STUB1 FLJ10357 VEGFB SYVN1 FLJ21986 WASF1 TRAF2 FLNC ZNF532 TRAM1 FUT8 ZWINT TUSC3 FYCO1 TXNDC5 GABARAPL1 UBE2D1 GABBR1 UBE2D2 GATM UBE2D3 GGH UBE2D4 GLS UBE2E1 GNG11 UBE2E2 GNPTAB UBE2E3 GPLD1 UBE2G1 GSN UBE2G2 GSTCD UBE2J1 GSTM2 UBE2J2 H2AFV UBE4B H2AFZ UBQLN1 HAS2 UBQLN2 HDAC5 UBQLN3 HECA UBQLN4 HGSNAT UBQLNL HMGB1 UBXN6 HMGCS1 UFD1L HMGN2 UGCGL1 HN1L UGCGL2 HNRNPAB VCP HNRPR WFS1 HSD17B7 XBP1 HSPC111 YOD1 HYLS1 MARCH06 ID2 ID3 IDI1 IFRD2 IGBP1 IL1R1 IL32 IL6ST IL7R IMP4 INSIG1 IPO4 ISCU

Remaining gene sets p3 ITGA6 ITPKB JARID1B JTV1 KIAA0090 KIAA0367 KIAA1109 KIT KLHL24 KLHL5 KRR1 LBA1 LDB1 LDLR LETMD1 LIPA LMNB2 LOC124512 LOC492311 LOXL2 LPIN1 LRIG2 LRP1 LRRC40 LSM3 LSS LUM LYAR MAF MAGI2 MAGOHB MAN1A1 MAP3K8 MAPRE1 MBP MCM3 MCM7 MCTS1 MED27 MEF2D MET MFGE8 MGC42105 MKKS MLF1IP MNAT1 MRPL12 MRPL37 MRPS16 MRPS28 MRPS6 MRTO4 MSN MT1A MT1L MT3 MTHFD1 MVD MXI1 MYBL2 MYCBP MYL6 NCOA3 NEK9 NHLRC3 NLN NOLA2

Remaining gene sets p4 NPTN NRIP3 NUDT1 NUDT15 NUP107 NUP35 NUP85 NUP93 NUPL1 NUPR1 OLFML2A OSBPL8 PA2G4 PARP14 PAX9 PBXIP1 PCMTD1 PDAP1 PDCD4 PDIA4 PDK2 PDZRN3 PFKP PFN1 PGCP PGM2 PHACS PHF19 PHF21A PIK3IP1 PITPNC1 PKIG PLA2R1 PLAUR PLD3 PLOD2 PLXNB1 PNN PNO1 PNRC1 POLE2 POLR3K POR PPAN PPIH PSMA7 PSMB7 PSMC3 PSMD12 PSMD14 PTPLB PTPRU PTS RAB11FIP2 RAB3B RANBP1 RARRES3 RBMX REV3L RFC3 RGS13 RHOC RNASE4 RNASEH2A RNF138 RNF146 RNF213

Remaining gene sets p5 RPL37 RPL9 RPN1 RPP40 RRM2B RUVBL1 SAR1B SATB1 SCD SDC1 SELENBP1 SERF2 SERPING1 SESN1 SESN2 SF3B1 SFRS10 SFRS11 SFTPB SH3BP5L SH3PXD2B SLC16A1 SLC22A17 SLC25A36 SLC25A40 SLC25A5 SLC27A1 SLC40A1 SLPI SMC2 SMS SMURF2 SNAG1 SNRP70 SNRPA SNRPA1 SNRPB SNRPC SNRPD1 SNRPE SOD2 SPAG17 SQLE SRM SSR3 ST6GAL1 STK17A STRA13 STX5 SUMF1 SVEP1 SVIL TAGLN TBRG1 TDP1 TFPI2 TIMM50 TIMP2 TMEM11 TMEM130 TMEM48 TNFAIP8 TNFRSF12A TNFSF13 TOMM40 TP53INP1 TPI1

Remaining gene sets p6 TPM1 TPM2 TPM3 TPRKB TRIM22 TRIM25 TRPA1 TSC22D1 TSC22D3 TUBA4A TUBG1 TXNL2 UAP1 UBE2J1 UCK2 UCRC UMPS USP44 VAMP4 VASH1 VIL2 VTA1 WDHD1 WDR26 WDR54 WDR77 WIPI1 WSB1 WSB2 YPEL3 ZBTB17 ZCCHC24 ZFP106 ZKSCAN1 ZNF83 ZWILCH

Remaining gene sets p7