The four hypoxia gene lists together with fold-change (Log2-transformed) of expression after hypoxia treatment in the cervical cancer cell lines HeLa, SiHa, and CaSki Hypoxia cervical up x3 Hypoxia cervical up & literature Hypoxia cervical down x3 Hypoxia cervical down & literature GeneSymbol HeLa SiHa CaSki GeneSymbol HeLa SiHa CaSki ABCA7 2.347 2.008 1.036 MLKL -1.298 -1.500 -1.089 ARID3A 1.369 3.040 1.256 NOL6 -2.084 -1.305 -1.543 C1ORF51 1.240 2.139 1.591 NOP2 -1.525 -1.531 -1.060 HIG2 2.781 2.185 2.158 PRMT3 -1.216 -1.084 -1.431 CMIP 1.190 1.003 1.130 ELOVL6 -1.743 -1.557 -1.490 FGF11 1.752 3.849 2.682 HSPH1 -1.796 -1.255 -1.002 FTH1P3 1.135 1.490 1.033 KIAA0020 -1.100 -1.184 -1.148 GPRC5C 1.011 4.025 1.307 LRP8 -1.099 -1.529 -1.248 HSF2BP 1.647 1.020 1.049 ODC1 -1.393 -1.578 -1.796 IRS2 1.552 1.128 1.352 VARS -1.772 -1.076 -1.125 LOC100008589 1.992 2.096 1.120 ABCF2 -1.129 -0.807 -0.725 LOC286016 2.431 1.532 1.232 ACOT7 0.125 -1.300 -0.933 LOC401152 2.016 2.262 1.810 ADAR -1.619 -0.198 -0.102 LOC441763 2.646 2.047 1.127 AIMP2 0.209 -1.330 -0.881 LOC644760 2.284 1.428 1.375 AMD1 -1.484 -0.639 -0.469 LOC644774 1.328 2.036 1.871 ANLN -1.210 -1.560 0.561 LOC645553 2.282 1.658 1.581 ATIC -1.036 -0.738 -0.834 LOC730525 1.548 1.646 1.668 ATP5G1 0.631 -1.445 -1.243 LOC732165 2.843 1.861 1.251 BCS1L -0.075 -1.010 -0.540 MALL 1.368 2.180 1.089 BOP1 -1.145 -0.863 -0.916 NMB 1.868 1.265 1.724 BRCA1 -0.006 -1.101 0.211 NUDT18 1.845 1.444 1.208 C12ORF48 -0.985 -1.219 -0.163 PGAM4 1.674 1.434 1.006 C17ORF80 -1.277 -0.462 -0.183 PIK3IP1 1.100 1.421 1.477 C1ORF135 0.187 -1.500 -0.493 SLPI 2.428 1.183 1.230 C1ORF163 -0.086 -1.042 -0.894 TMEM145 1.029 2.401 1.514 C20ORF27 0.405 -1.387 -0.368 TMEM158 1.044 1.249 1.238 CAD -0.761 -1.093 -0.449 TNNT1 1.835 1.628 1.107 CALD1 -1.040 0.595 0.297 VKORC1 2.453 1.792 1.373 CALM1 -1.207 0.078 0.015 ADM 2.973 2.359 1.489 CAPRIN1 -1.580 -0.417 -0.432 AK3L1 2.063 2.590 1.208 CBX6 -1.918 -0.278 -0.426 ALDOA 1.690 1.475 1.132 CCDC86 -0.680 -0.405 -1.109 ALDOC 4.288 3.918 1.793 CCDC99 -0.432 -1.171 -0.089 ANG 3.058 2.225 2.283 CCNA2 -0.759 -2.159 -0.416 ANKRD37 3.809 3.731 2.380 CCND1 -2.287 -0.046 -1.584 ANKZF1 1.881 1.781 1.406 CCND3 -1.286 -1.117 -0.457 BHLHB2 1.010 1.540 1.752 CCNF -1.695 -1.787 -0.168 BNIP3 3.299 3.392 2.598 CCT6A -1.337 -0.755 -0.723 BNIP3L 2.044 3.613 2.839 CDC2 0.064 -1.654 -0.063 BTG1 1.754 1.455 1.556 CDC20 -0.958 -2.065 -0.514 CA9 5.977 6.104 4.825 CDCA4 0.908 -1.040 0.070 Cervix cancer hypoxia gene sets p1 CCNG2 1.247 1.252 1.149 CENPF -1.248 -1.798 0.016 CDKN1A 1.109 1.595 1.043 CENPN 0.917 -1.019 -0.002 DDIT4 1.750 2.234 3.578 CNOT7 -1.130 0.122 0.031 EGLN1 1.484 1.323 1.307 COL18A1 -1.254 0.106 0.117 EGLN3 1.561 2.161 1.388 CORO1C -1.019 0.396 -0.122 ENO2 2.870 2.553 2.797 CSDE1 -1.096 -0.145 -0.429 ERRFI1 2.967 1.389 2.106 CSE1L -1.255 -1.115 -0.763 FAM162A 2.850 2.294 2.033 CTPS -0.962 -1.048 -0.897 GAPDH 1.072 1.277 1.072 CYTSA -1.050 0.120 0.364 GPI 1.627 1.427 1.374 DDX23 -1.297 -0.695 -0.305 HCFC1R1 2.269 1.333 1.082 DDX3X -1.320 0.261 0.206 HK2 1.782 3.158 1.346 DHCR24 -1.102 -0.517 -0.323 IGFBP3 3.043 3.780 2.288 DHX29 -1.190 -0.536 -0.533 INSIG2 1.831 2.272 2.012 DLAT -1.222 -0.123 -0.482 JMJD1A 1.064 1.763 1.592 EEF2 -1.349 0.669 0.305 KCTD11 1.244 1.842 1.925 EFEMP1 -1.215 -0.783 -0.609 LOX 1.890 4.247 2.822 EFTUD2 -1.033 -0.505 -0.446 MUC1 1.335 2.392 2.193 ERCC6L -0.576 -1.556 -0.357 NDRG1 3.436 3.424 3.953 EXO1 -0.290 -2.210 -0.193 P4HA1 1.870 2.587 2.051 FANCG -0.260 -1.046 -0.127 P4HA2 1.840 2.805 1.544 FANCI -1.087 -1.405 0.175 PFKFB4 2.657 3.671 3.575 FASN -1.587 -0.899 -0.930 PGAM1 1.422 1.527 1.128 FASTKD5 -1.196 -0.539 -0.489 PGK1 1.444 1.986 1.867 FBXO5 0.093 -1.301 0.182 PLOD2 1.456 2.232 2.103 FEN1 0.316 -1.146 -0.151 PPFIA4 2.129 2.214 1.783 FGF2 -1.315 0.002 -0.179 PTPRR 1.281 1.040 1.325 GART -0.728 -1.122 -0.666 RNASE4 2.273 2.595 2.358 GINS3 0.101 -1.234 -0.046 RNF24 1.143 1.574 1.094 GLRX2 0.586 -1.086 -0.081 SH3GL3 1.747 2.739 1.548 GMFB -1.598 -0.047 0.058 SPRY1 1.996 2.727 2.146 GNA13 -1.044 0.237 0.341 STC2 2.540 4.348 2.824 GNPDA1 -1.011 -0.348 -0.765 TMEM45A 3.846 3.741 2.560 GPD1L -1.423 -0.761 -0.754 TPI1 1.617 1.254 1.016 GPR56 -1.196 -0.299 -0.211 VLDLR 1.869 2.711 1.762 GULP1 -1.058 -0.236 -0.196 WDR54 2.383 1.816 1.126 H2AFX 0.771 -1.253 -0.021 YPEL5 1.146 1.687 1.374 HEATR1 -1.799 -0.753 -0.503 ZNF395 2.073 2.886 1.569 HIF1A -1.006 0.596 0.146 ABCA1 -0.566 1.133 1.038 HJURP 0.120 -1.879 -0.078 ABCB6 0.513 1.258 0.975 HMBS 0.457 -1.329 -0.659 ADORA2B 1.560 1.459 -0.602 HSPA1A -1.351 -0.459 -0.610 AK2 1.090 0.429 0.122 HSPA1B -1.255 -0.478 -0.393 ANGPTL4 0.776 3.486 3.613 HSPA4 -1.137 -0.197 -0.328 ANKRD9 1.323 0.985 0.218 HSPC111 0.522 -1.183 -1.208 AOX1 0.728 1.718 -0.006 HSPD1 -1.005 -0.604 -0.761 APITD1 1.096 -0.691 -0.139 HSPE1 -0.209 -0.650 -1.042 ARRDC3 0.009 1.491 1.208 IARS -1.211 -0.657 0.210 ATF3 0.906 0.413 1.158 IDE -1.688 -0.756 -0.574 ATP1B1 1.084 1.413 0.098 IDH3A -1.135 -0.246 -0.920 ATP5O 1.132 -0.005 0.026 KIF23 -1.138 -1.985 -0.259 Cervix cancer hypoxia gene sets p2 AXL -0.567 1.397 0.282 KIF4A -0.425 -1.507 0.195 B3GNT4 0.338 1.955 0.305 KIAA0101 0.967 -1.571 -0.016 BAX 1.735 -0.341 0.300 KIAA0564 -1.168 -0.249 -0.024 BIK 0.651 1.866 1.428 KPNA4 -1.243 -0.268 -0.209 BLVRB 1.053 0.049 0.395 LARP4 -1.457 -0.185 -0.342 BOLA2 1.497 -0.647 -0.404 LARS2 -1.173 -0.350 -0.321 C10ORF10 -0.038 0.142 1.493 LDLR -1.288 -1.117 -0.527 C12ORF24 1.243 1.066 -0.122 LETM1 -1.272 -0.711 -0.283 C14ORF2 1.088 -0.073 -0.307 MAD2L1 0.132 -1.428 -0.372 C16ORF74 1.218 1.213 0.157 MCL1 -1.098 -0.925 -0.564 C19ORF53 1.285 -0.399 -0.252 MCM10 0.290 -1.317 0.082 C3ORF10 1.503 1.172 0.514 MELK 0.047 -1.760 0.152 C5ORF13 0.334 1.683 0.655 MEST -1.412 -0.344 -1.058 CA12 1.678 3.304 0.067 MNS1 0.403 -1.627 -0.342 CAV1 0.841 1.166 0.571 MPHOSPH9 -1.160 -1.078 -0.184 CD99 1.715 0.817 0.275 MRTO4 0.337 -0.766 -1.027 CDC2L6 -0.068 1.102 0.968 NARS -1.019 -0.554 -0.062 CDKN1C 2.384 0.260 0.569 NAT10 -1.292 0.384 -0.703 CEBPB -0.101 0.026 1.001 NCAPG2 -0.380 -1.386 0.149 CEBPD 1.443 0.538 -0.132 NFKB1 -1.400 -0.366 -0.056 CECR5 0.929 1.015 0.189 NME1 0.496 -0.794 -1.216 CFD 2.469 0.979 0.227 NMT1 -1.732 0.027 -0.234 CHSY1 -0.233 1.734 0.291 NOL11 -1.415 -0.646 -0.621 CITED2 1.169 1.802 0.705 NOL12 0.073 -1.151 -0.245 CKB 1.890 0.588 0.008 NOLC1 -1.484 -1.202 -0.683 CNOT8 0.670 1.084 0.522 NOP56 -0.055 -1.156 -0.896 COL5A1 -0.435 1.433 1.274 NUP160 -1.471 -0.682 -0.277 CRLF1 1.139 0.325 -0.179 NUP205 -1.094 -0.659 -0.373 CSNK2B 1.350 -0.076 0.041 NUP85 -0.195 -1.014 -0.050 CSRP2 1.666 0.831 0.877 NUSAP1 -0.421 -1.484 0.059 CXCR4 1.263 -0.103 -0.226 OIP5 0.708 -1.344 -0.251 CXCR7 0.862 1.242 0.019 ORC6L 0.491 -1.937 -0.195 CYB5A 1.006 -0.386 -0.263 PA2G4 0.537 -1.312 -0.524 DDIT3 1.510 0.383 1.210 PARP1 -1.243 -0.107 -0.436 DDX41 0.771 1.371 0.448 PARP2 0.079 -1.158 -0.138 DPM2 1.172 -0.236 -0.081 PBK -0.062 -1.564 -0.500 DPYSL2 0.402 0.634 1.053 PCYT2 -0.138 -1.118 -0.410 DPYSL4 -0.368 2.636 -0.001 PER3 -0.558 -1.166 -0.007 DUSP1 0.912 1.460 0.351 PFAS -1.751 -0.950 -0.896 EBP 1.232 -0.958 0.128 PKMYT1 0.817 -2.080 0.241 EBPL 1.350 0.483 -0.352 POLA2 -0.547 -1.209 -0.064 ECE2 1.042 0.292 -0.382 POLE2 0.201 -1.336 -0.409 EDN2 3.570 4.209 0.234 PPARG -0.776 -1.137 -1.003 EFNA1 0.979 1.167 0.199 PPAT -1.019 -0.274 -0.728 EIF1B 1.146 -0.204 -0.007 PRC1 -0.925 -2.004 0.037 ELF3 0.644 1.000 0.234 PSMC3IP 0.968 -1.311 -0.051 ELL2 -0.211 1.121 0.347 PSME3 -1.137 -0.291 -0.746 EMP3 1.520 0.523 0.130 PSME4 -1.482 -0.209 -0.411 EPOR 1.192 0.579 0.195 PSMG1 0.414 -1.022 -0.234 ERO1L 0.366 1.651 1.200 RAD51AP1 -0.175 -1.706 0.160 Cervix cancer hypoxia gene sets p3 EXOSC8 1.014 -0.851 0.010 RAI14 -1.110 -0.506 -0.564 FABP5 1.064 -0.677 -0.571 RANBP1 0.483 -1.052 -0.555 FAM119B 0.455 2.121 0.188 RANGAP1 -1.780 -1.127 -0.093 FAM13A 0.477 1.480 0.405 RBM12 -1.059 -0.525 -0.595 FAM46A -0.150 0.863 1.220 RFC3 -0.610 -1.683 -0.449 FER1L4 -0.342 1.610 -0.702 RFC5 0.099 -1.121 -0.208 FLNB 0.336 0.889 1.217 RNF14 -1.102 -0.035 0.054 FOS -0.885 1.942 -0.125 RPP40 0.377 -1.140 -1.085 FOXD1 1.943 1.495 0.117 RRM1 -0.622 -1.108 -0.228 FOXO3 0.077 1.109 0.200 RRM2 -0.206 -2.346 -0.141 GADD45B 1.261 0.867 0.701 RRP1B -1.065 0.003 -0.282 GBE1 0.914 2.877 1.318 RRP9 -0.423 -0.799 -1.240 GLRX 1.662 1.357 0.792 RRS1 -0.136 -1.356 -1.362 GLS -0.019 1.196 0.402 SCD -1.111 0.357 0.555 GPRC5A 1.506 1.491 0.762 SEH1L -1.198 -0.338 -0.473 GRSF1 -0.572 1.387 0.104 SEL1L3 -1.208 -0.360 0.279 GYS1 0.988 1.636 0.751 SFRS1 -1.127 -0.649 -0.477 HBP1 0.450 1.129 0.793 SIP1 0.236 -1.039 -0.523 HERC3 0.400 1.098 0.483 SKP2 -0.960 -1.096 -1.221 HERPUD1 1.091 0.650 0.996 SLC11A2 -1.308 0.056 -0.553 HLA-B 1.698 1.426 0.340 SLC25A44 -1.506 -0.335 -0.162 HLA-DQB1 0.023 3.361 0.180 SLC5A6 -1.374 -1.096 -0.822 HLA-DRB1 0.183 2.991 -0.030 SQLE -0.603 -1.022 -0.209 HMHA1 -0.254 1.168 0.880 SRM 0.339 -0.793 -1.180 HMOX1 0.906 1.092 1.799 STIL -1.009 -1.678 0.169 HOMER1 -0.334 1.193 -0.080 TFRC -1.022 0.889 -0.568 HSPA5 -0.478 1.610 -0.014 THBS1 -1.017 0.369 -0.129 ID1 1.720 0.294 -0.424 TIPIN 0.079 -0.888 -1.095 ID2 1.955 0.309 0.528 TMTC3 -1.577 -0.162 -0.211 IDH2 1.901 0.384 0.608 TPX2 -1.318 -2.036 0.195 IER3 2.286 2.491 0.987 TRIOBP 0.040 -1.082 -0.213 IGFBP2 1.066 -0.114 0.108 TRIP13 -0.193 -1.838 -0.554 IGFBP5 1.111 2.282 -0.673 TRMT5 0.064 -1.216 -0.230 IGFBP7 1.311 0.253 0.408 TSEN2 -1.032 -0.775 -1.046 ILVBL 0.189 1.214 0.709 TUBB2C 0.240 -1.179 -0.138 IMMP2L 1.278 0.839 -0.101 TUBG1 0.434 -1.208 -0.149 IMP3 1.238 0.774 0.473 TUBGCP4 -1.057 -0.406 -0.497 INHBE 1.329 0.061 0.094 VWF -1.155 0.167