Beyond the Psychedelic Experience
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The Ethics of Psychedelic Medicine: a Case for the Reclassification of Psilocybin for Therapeutic Purposes
THE ETHICS OF PSYCHEDELIC MEDICINE: A CASE FOR THE RECLASSIFICATION OF PSILOCYBIN FOR THERAPEUTIC PURPOSES By Akansh Hans A thesis submitted to Johns Hopkins University in conformity with the requirements for the degree of Master of Bioethics Baltimore, Maryland May 2021 © 2021 Akansh Hans All Rights Reserved I. Abstract Our current therapeutic mental health paradigms have been unable to adequately handle the mental illness crisis we are facing. We ought to ‘use every tool in our toolbox’ to help individuals heal, and the tool we should be utilizing right now is Psilocybin. Although it is classified as a Schedule I drug, meaning that it is believed to have a high potential for abuse, no accepted medical uses, and a lack of safety when used under medical supervision, Psilocybin is not addictive and does not have a high potential for abuse when used safely under medical supervision. For these reasons alone, Psilocybin deserves a reclassification for therapeutic purposes. However, many individuals oppose Psilocybin-assisted psychotherapy on ethical grounds or due to societal concerns. These concerns include: a potential change in personal identity, a potential loss of human autonomy, issues of informed consent, safety, implications of potential increased recreational use, and distributive justice and fairness issues. Decriminalization, which is distinct from reclassification, means that individuals should not be incarcerated for the use of such plant medicines. This must happen first to stop racial and societal injustices from continuing as there are no inherently ‘good’ or ‘bad’ drugs. Rather, these substances are simply chemicals that humans have developed relationships with. As is shown in this thesis, the ethical implications and risks of psychedelic medicine can be adequately addressed and balanced, and the benefits of Psilocybin as a healing tool far outweigh the risks. -
Hallucinogens
Hallucinogens What Are Hallucinogens? Hallucinogens are a diverse group of drugs that alter a person’s awareness of their surroundings as well as their thoughts and feelings. They are commonly split into two categories: classic hallucinogens (such as LSD) and dissociative drugs (such as PCP). Both types of hallucinogens can cause hallucinations, or sensations and images that seem real though they are not. Additionally, dissociative drugs can cause users to feel out of control or disconnected from their body and environment. Some hallucinogens are extracted from plants or mushrooms, and others are synthetic (human-made). Historically, people have used hallucinogens for religious or healing rituals. More recently, people report using these drugs for social or recreational purposes. Hallucinogens are a Types of Hallucinogens diverse group of drugs Classic Hallucinogens that alter perception, LSD (D-lysergic acid diethylamide) is one of the most powerful mind- thoughts, and feelings. altering chemicals. It is a clear or white odorless material made from lysergic acid, which is found in a fungus that grows on rye and other Hallucinogens are split grains. into two categories: Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) comes from certain classic hallucinogens and types of mushrooms found in tropical and subtropical regions of South dissociative drugs. America, Mexico, and the United States. Peyote (mescaline) is a small, spineless cactus with mescaline as its main People use hallucinogens ingredient. Peyote can also be synthetic. in a wide variety of ways DMT (N,N-dimethyltryptamine) is a powerful chemical found naturally in some Amazonian plants. People can also make DMT in a lab. -
From Sacred Plants to Psychotherapy
From Sacred Plants to Psychotherapy: The History and Re-Emergence of Psychedelics in Medicine By Dr. Ben Sessa ‘The rejection of any source of evidence is always treason to that ultimate rationalism which urges forward science and philosophy alike’ - Alfred North Whitehead Introduction: What exactly is it that fascinates people about the psychedelic drugs? And how can we best define them? 1. Most psychiatrists will define psychedelics as those drugs that cause an acute confusional state. They bring about profound alterations in consciousness and may induce perceptual distortions as part of an organic psychosis. 2. Another definition for these substances may come from the cross-cultural dimension. In this context psychedelic drugs may be recognised as ceremonial religious tools, used by some non-Western cultures in order to communicate with the spiritual world. 3. For many lay people the psychedelic drugs are little more than illegal and dangerous drugs of abuse – addictive compounds, not to be distinguished from cocaine and heroin, which are only understood to be destructive - the cause of an individual, if not society’s, destruction. 4. But two final definitions for psychedelic drugs – and those that I would like the reader to have considered by the end of this article – is that the class of drugs defined as psychedelic, can be: a) Useful and safe medical treatments. Tools that as adjuncts to psychotherapy can be used to alleviate the symptoms and course of many mental illnesses, and 1 b) Vital research tools with which to better our understanding of the brain and the nature of consciousness. Classifying psychedelic drugs: 1,2 The drugs that are often described as the ‘classical’ psychedelics include LSD-25 (Lysergic Diethylamide), Mescaline (3,4,5- trimethoxyphenylathylamine), Psilocybin (4-hydroxy-N,N-dimethyltryptamine) and DMT (dimethyltryptamine). -
Adverse Reactions to Hallucinogenic Drugs. 1Rnstttutton National Test
DOCUMENT RESUME ED 034 696 SE 007 743 AUTROP Meyer, Roger E. , Fd. TITLE Adverse Reactions to Hallucinogenic Drugs. 1rNSTTTUTTON National Test. of Mental Health (DHEW), Bethesda, Md. PUB DATP Sep 67 NOTE 118p.; Conference held at the National Institute of Mental Health, Chevy Chase, Maryland, September 29, 1967 AVATLABLE FROM Superintendent of Documents, Government Printing Office, Washington, D. C. 20402 ($1.25). FDPS PRICE FDPS Price MFc0.50 HC Not Available from EDRS. DESCPTPTOPS Conference Reports, *Drug Abuse, Health Education, *Lysergic Acid Diethylamide, *Medical Research, *Mental Health IDENTIFIEPS Hallucinogenic Drugs ABSTPACT This reports a conference of psychologists, psychiatrists, geneticists and others concerned with the biological and psychological effects of lysergic acid diethylamide and other hallucinogenic drugs. Clinical data are presented on adverse drug reactions. The difficulty of determining the causes of adverse reactions is discussed, as are different methods of therapy. Data are also presented on the psychological and physiolcgical effects of L.S.D. given as a treatment under controlled medical conditions. Possible genetic effects of L.S.D. and other drugs are discussed on the basis of data from laboratory animals and humans. Also discussed are needs for futher research. The necessity to aviod scare techniques in disseminating information about drugs is emphasized. An aprentlix includes seven background papers reprinted from professional journals, and a bibliography of current articles on the possible genetic effects of drugs. (EB) National Clearinghouse for Mental Health Information VA-w. Alb alb !bAm I.S. MOMS Of NAM MON tMAN IONE Of NMI 105 NUNN NU IN WINES UAWAS RCM NIN 01 NUN N ONMININI 01011110 0. -
Ritualized Peyote Use Can Facilitate Mental Health, Social Solidarity
Ritualized Peyote Use Can Facilitate Mental Health, Social Solidarity, and Cultural Survival: A Case Study of the Religious and Mystical Experiences in the Wixárika People of the Sierra Madre Occidental The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Luce, Nathan William. 2020. Ritualized Peyote Use Can Facilitate Mental Health, Social Solidarity, and Cultural Survival: A Case Study of the Religious and Mystical Experiences in the Wixárika People of the Sierra Madre Occidental. Master's thesis, Harvard Extension School. Citable link https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37365056 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Ritualized Peyote Use Can Facilitate Mental Health, Social Solidarity, and Cultural Survival: A Case Study of the Religious and Mystical Experiences in the Wixárika People of the Sierra Madre Occidental Nathan William Luce A Thesis in the Field of Religion for the Degree of Master of Liberal Arts in Extension Studies Harvard University May 2020 Copyright 2020 Nathan William Luce Abstract This paper examines how the Wixárika, or Huichol, as they are more commonly known to the outside world, have successfully engaged in a decade-long struggle to save their ceremonial homeland of Wirikuta. They have fended off a Canadian silver mining company’s attempts to dig mines in the habitat of their most important sacrament, peyote, using a remarkable combination of traditional and modern resistance techniques. -
Psilocybin Mushrooms Fact Sheet
Psilocybin Mushrooms Fact Sheet January 2017 What are psilocybin, or “magic,” mushrooms? For the next two decades thousands of doses of psilocybin were administered in clinical experiments. Psilocybin is the main ingredient found in several types Psychiatrists, scientists and mental health of psychoactive mushrooms, making it perhaps the professionals considered psychedelics like psilocybin i best-known naturally-occurring psychedelic drug. to be promising treatments as an aid to therapy for a Although psilocybin is considered active at doses broad range of psychiatric diagnoses, including around 3-4 mg, a common dose used in clinical alcoholism, schizophrenia, autism spectrum disorders, ii,iii,iv research settings ranges from 14-30 mg. Its obsessive-compulsive disorder, and depression.xiii effects on the brain are attributed to its active Many more people were also introduced to psilocybin metabolite, psilocin. Psilocybin is most commonly mushrooms and other psychedelics as part of various found in wild or homegrown mushrooms and sold religious or spiritual practices, for mental and either fresh or dried. The most popular species of emotional exploration, or to enhance wellness and psilocybin mushrooms is Psilocybe cubensis, which is creativity.xiv usually taken orally either by eating dried caps and stems or steeped in hot water and drunk as a tea, with Despite this long history and ongoing research into its v a common dose around 1-2.5 grams. therapeutic and medical benefits,xv since 1970 psilocybin and psilocin have been listed in Schedule I of the Controlled Substances Act, the most heavily Scientists and mental health professionals criminalized category for drugs considered to have a consider psychedelics like psilocybin to be “high potential for abuse” and no currently accepted promising treatments as an aid to therapy for a medical use – though when it comes to psilocybin broad range of psychiatric diagnoses. -
Den Zauberpilze-Trip Bald Auf Rezept?
FrequentlyAskedQuestions Forschung –––Gibt es sagt Watts.DaPsilocybininGroßbritannien noch in der Kategorie„Schedule One“ geführt wird undsozu denZauberpilze-Trip gefährlichenillegalen Drogen wieKokainund Heroin 2 zählt, gestaltetsichdie Erforschungschwierig.Doch nichtnur Forscher hoffenauf eine Entwicklungwie bald aufRezept? beiCannabis,was in immermehrLändernals Medizi- nalhanfvon bestimmten Patienten konsumiert werden darf –wie etwa in Deutschlandund England,was vor wenigenJahrennochundenkbar schien.Inden Verei- Text nigten Staaten istCannabisbereitsBig Business,und anne philippi Seitdemman weiß, dass sich Apple-Mitgründer Steve der Marktfür psychedelische Pilze wird in Kalifornien, Jobs einstauchvon LSDinspirieren ließ unddassdas dasimmer schoneineVorreiterrollehatte,als dernächste SiliconValleydie sogenannten „Nootropics“,also„smart großePost-Cannabis-Markt angesehen. Investoren vor drugs“, zurVerbesserung vonKreativität wiederentdeckt allemaus der Bio-Techwelt stehen bereit, entsprechende hat, kehrtauchdas Interessen an LSDund Psilocybin Studienzufinanzieren. Solche,die zu einerschnelle- zurück,das in psychoaktivenPilzenenthalten ist, die renLegalisierung der Stoffeineinem therapeutischen auchals Zauberpilze, MagicMushrooms oder halluzino- Rahmen beitragenkönnten.SohabenGroßinvestor gene Pilze bekannt sind.Zunehmend aber werden diese Peter Thiel undChristian Angermayer Geld in das Substanzenauchals Heilmittel gegenDepressionund Start-up CompassPathwaysgesteckt, welchesPsilocybin Angstzuständeerforscht.Kürzlichersthat dasImperial -
Neural and Subjective Effects of Inhaled DMT in Natural Settings
bioRxiv preprint doi: https://doi.org/10.1101/2020.08.19.258145; this version posted August 20, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Neural and subjective effects of inhaled DMT in natural settings Carla Pallavicini1,2 *, Federico Cavanna1,2, Federico Zamberlan1, Laura Alethia de la Fuente1, Mauricio Arias3, Celeste Romero4, Robin Carhart-Harris5, Christopher Timmermann5, Enzo Tagliazucchi1 * 1Departamento de Física, Universidad de Buenos Aires and Instituto de Física de Buenos Aires (IFIBA – CONICET), Pabellón I, Ciudad Universitaria (1428), CABA, Buenos Aires, Argentina 2Fundación para la lucha contra las enfermedades neurológicas de la infancia (FLENI), Montañeses 2325, C1428 CABA, Buenos Aires, Argentina 3Hospital General de Agudos Donación Francisco Santojanni, Pilar 950, C1408INH CABA, Buenos Aires, Argentina 4Centro de Estudios de la Cultura Cannábica (CECCa), Humahuaca 3947, C1192ACA CABA, Buenos Aires, Argentina 5Centre for Psychedelic Research, Department of Medicine, Imperial College London, Kensington, London SW7 2DD, United Kingdom *Corresponding authors: [email protected] , [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.08.19.258145; this version posted August 20, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Abstract N,N-Dimethyltryptamine (DMT) is a short acting psychedelic tryptamine found naturally in many plants and animals. -
CLINICAL STUDY PROTOCOL Psilocybin-Assisted Psychotherapy
CLINICAL STUDY PROTOCOL Psilocybin-assisted Psychotherapy in the Management of Anxiety Associated With Stage IV Melanoma. Version: Final IND: [79,321] SPONSOR Multidisciplinary Association for Psychedelic PRINCIPAL INVESTIGATOR Sameet Kumar Ph.D. MEDICAL MONITOR Michael C. Mithoefer MD. STUDY PERSONNEL XXXXXXXXXXXXX XXXXXXXXXXXXX XXXXXXXXXXXXX STUDY MONITOR [CRA] Valerie Mojeiko IRB Study Site IRB Sponsor Signatory Rick Doblin Ph.D. Study Period 2008 For trial related emergencies please contact: Dr. Michael Mithoefer MAPS: S Kumar PI Clinical Study Protocol PCA1 Final December 1, 2007 Confidential Page 2 of 83 Table of Contents Introduction......................................................................................................................... 4 Background..................................................................................................................... 4 Disease History and Related Research ........................................................................... 5 Rationale ......................................................................................................................... 7 Summary......................................................................................................................... 7 Ethics................................................................................................................................... 8 Informed Consent of Subject .......................................................................................... 9 Recruitment and Screening............................................................................................ -
The Psychedelic Experience: the Importance of ‘Set’ and ‘Setting’
The Psychedelic Experience: The Importance of ‘Set’ and ‘Setting’ Matthew Nour & Jacob Krzanowski Matthew Nour, CT1 in Psychiatry, South London and Maudsley NHS Foundation Trust; Jacob Krzanowski, CT1 in Psychiatry, South London and Maudsley NHS Foundation Trust. Email: [email protected] *Both authors contributed equally to this work We welcome the renewed interest in the therapeutic potential of psychedelic compounds. In their recent editorial, Sessa and Johnson1 echo the fervent research climate surrounding psychedelics spanning the 1950s and 60s. They suggest that psychedelics may cause prolonged changes in subjects’ personalities and attitudes following mystical-spiritual experiences. This unique and exciting potential mechanism of action certainly warrants the current renaissance in psychedelic research, and has important implications for study design and subject selection. As we move towards re-exploring the clinical applications of psychedelics, however, we must appreciate that the phenomenology of the psychedelic experience is likely to depend not only on a drug’s pharmacodynamic properties, but also on the makeup of the subject (‘set’) and the environmental context (‘setting’) in which the drug is administered. Recent work suggests that the potential importance of ‘set’ in the psychedelic experience should not be overlooked. Hallucinogenic compounds act via the serotonergic 5-HT2A receptor to effect experience and behaviour. Genetic and neuroimaging evidence suggests that inter-subject differences in serotonergic neurotransmission -
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Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanismss
Supplemental Material can be found at: /content/suppl/2020/12/18/73.1.202.DC1.html 1521-0081/73/1/202–277$35.00 https://doi.org/10.1124/pharmrev.120.000056 PHARMACOLOGICAL REVIEWS Pharmacol Rev 73:202–277, January 2021 Copyright © 2020 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license. ASSOCIATE EDITOR: MICHAEL NADER Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanismss Antonio Inserra, Danilo De Gregorio, and Gabriella Gobbi Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Quebec, Canada Abstract ...................................................................................205 Significance Statement. ..................................................................205 I. Introduction . ..............................................................................205 A. Review Outline ........................................................................205 B. Psychiatric Disorders and the Need for Novel Pharmacotherapies .......................206 C. Psychedelic Compounds as Novel Therapeutics in Psychiatry: Overview and Comparison with Current Available Treatments . .....................................206 D. Classical or Serotonergic Psychedelics versus Nonclassical Psychedelics: Definition ......208 Downloaded from E. Dissociative Anesthetics................................................................209 F. Empathogens-Entactogens . ............................................................209