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Home , ADCY5, ATP2A2, CDH8, GNB4, GNG13, GUCY1A3

Supplemental Table 1. activated by alcohol in cultured cortical neurons, as assessed by micro-array analysis.

Gene Description Genbank Acc No Folds of increase Gpnmb glycoprotein (transmembrane) nmb NM_053110 2.58 Lyzs lysozyme NM_017372 2.36 Gpnmb glycoprotein (transmembrane) nmb NM_053110 2.33 Gpnmb glycoprotein (transmembrane) nmb NM_053110 2.27 Gpm6a glycoprotein m6a NM_153581 2.05 Mtap1b -associated 1 B NM_008634 2.00 Gfap glial fibrillary acidic protein NM_010277 1.94 C1qg complement component 1, q subcomponent, C chain NM_007574 1.90 C1qb complement component 1, q subcomponent, beta polypeptide, mRNA NM_009777 1.87 Laptm5 lysosomal-associated protein transmembrane 5 NM_010686 1.82 Apoc1 C-I NM_007469 1.81 Lgals3 lectin, galactose binding, soluble 3 NM_010705 1.81 Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide NM_010185 1.81 Cd68 CD68 antigen NM_009853 1.81 Apoe NM_009696 1.76 C1qa complement component 1, q subcomponent, alpha polypeptide NM_007572 1.75 Lgmn legumain NM_011175 1.74 Msr2 macrophage scavenger receptor 2 NM_030707 1.72 Trem2 triggering receptor expressed on myeloid cells 2 NM_031254 1.72 Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N NM_009252 1.71 Igf1 -like growth factor 1, transcript variant 1 NM_010512 1.71 Ctsz cathepsin Z NM_022325 1.71 Adfp adipose differentiation related protein NM_007408 1.69 Pdgfra platelet derived growth factor receptor, alpha polypeptide NM_011058 1.67 Mmp12 matrix metallopeptidase 12 NM_008605 1.66 Nrgn neurogranin NM_022029 1.65 4831417L10 ELMO domain containing 1 NM_177769 1.64 Cyba cytochrome b-245, alpha polypeptide NM_007806 1.63 Eef2 eukaryotic translation 2 NM_007907 1.63 Ctsb cathepsin B NM_007798 1.62 Bcl2a1a B-cell leukemia/lymphoma 2 related protein A1b NM_007534 1.61 Apoc1 -I NM_007469 1.61 Abcg1 ATP-binding cassette, sub-family G (WHITE), member 1 NM_009593 1.61 Igf1 insulin-like growth factor 1, transcript variant 2 NM_184052 1.59 Trf transferrin NM_133977 1.57 elf1; elf3 beta 2, transcript variant 1 NM_175836 1.57 Hnrpk heterogeneous nuclear ribonucleoprotein K NM_025279 1.57 Mtap1b microtubule-associated protein 1 B NM_008634 1.57 Gpc5 glypican 5 NM_175500 1.57 Grn granulin NM_008175 1.57 Fcgr3 Fc receptor, IgG, low affinity III NM_010188 1.56 Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d NM_007536 1.55 Lpl NM_008509 1.54

1

Sec23a SEC23A (S. cerevisiae) NM_009147 1.53 Ly86 lymphocyte antigen 86 NM_010745 1.53 Syt1 I NM_009306 1.53 Cdh13 13 NM_019707 1.52 Blnk B-cell linker NM_008528 1.52 Sgk serum/glucocorticoid regulated kinase NM_011361 1.51 Igf1 insulin-like growth factor 1, transcript variant 1 NM_010512 1.51

2

Supplemental Table 2. Genes activated by heat shock in cultured cortical neurons, as assessed by micro-array analysis.

Gene Description Genbank Acc No Ranking

Gucy1a3 guanylate 1, soluble, alpha 3 (Gucy1a3) NM_021896 3.34 Sv2b synaptic vesicle glycoprotein 2 b (Sv2b), NM_153579 3.10 Dfy Duffy blood group, chemokine receptor (Darc) NM_010045 2.58 Fst follistatin (Fst) NM_008046 2.58 Gucy1a3 1, soluble, alpha 3 (Gucy1a3) NM_021896 2.57 Gpc5 glypican 5 (Gpc5), NM_175500 2.39 Gucy1b3 guanylate cyclase 1, soluble, beta 3 (Gucy1b3) NM_017469 2.38 Nrgn neurogranin (Nrgn) NM_022029 2.38 Tes testis derived transcript (Tes) NM_011570 2.37 Gucy1a3 guanylate cyclase 1, soluble, alpha 3 (Gucy1a3) NM_021896 2.36 3110047P20Rik RIKEN cDNA 3110047P20 gene (3110047P20Rik XM_132047 2.33 Gpr88 G-protein coupled receptor 88 (Gpr88) NM_022427 2.31 Nef3 , medium polypeptide (Nefm), NM_008691 2.26 Cbln1 cerebellin 1 precursor protein (Cbln1 NM_019626 2.26 Ttr transthyretin (Ttr), NM_013697 2.24 Efcbp1 EF hand calcium binding protein 1 (Efcbp1), NM_178617 2.23 Pcsk2 proprotein convertase subtilisin/kexin type 2 (Pcsk2), NM_008792 2.22 Spnb3 spectrin beta 3 (Spnb3 XM_129130 2.18 Cdh13 cadherin 13 (Cdh13), NM_019707 2.18 Syt1 synaptotagmin I (Syt1) NM_009306 2.15 Cdh13 cadherin 13 (Cdh13), NM_019707 2.15 Nnat neuronatin (Nnat) NM_010923 2.15 4831417L10 domain containing 1 (Elmod1) NM_177769 2.10 Stmn4 -like 4 (Stmn4) NM_019675 2.10 Dmn desmuslin (Dmn) NM_207663 2.09 Caln1 calneuron 1 (Caln1) NM_021371 2.09 Prss12 protease, serine, 12 neurotrypsin (motopsin) (Prss12) NM_008939 2.09 Ngef neuronal guanine nucleotide exchange factor (Ngef) NM_019867 2.08 Spock1 sparc/, cwcv and kazal-like domains proteoglycan 1 (Spock1) NM_009262 2.06 Hpca (Hpca) NM_010471 2.05 Rac3 RAS-related C3 botulinum substrate 3 (Rac3) NM_133223 2.05 DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed D3Bwg0562e (D3Bwg0562e) NM_177664 2.05 Ntf3 neurotrophin 3 (Ntf3) NM_008742 2.03 Ppp2r2c protein 2, regulatory subunit B (PR 52), gamma isoform (Ppp2r2c) NM_172994 2.01 Syt4 synaptotagmin IV (Syt4) NM_009308 2.00 Epha8 Eph receptor A8 (Epha8) NM_007939 2.00 Zfp537 teashirt zinc finger family member 3 (Tshz3) NM_172298 1.99 Chst8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 (Chst8) NM_175140 1.99 Zfp238 zinc finger protein 238 (Zfp238) NM_013915 1.99 AI836003 expressed sequence AI836003 (AI836003) NM_177716 1.98 Slc29a4 solute carrier family 29 (nucleoside transporters), member 4 (Slc29a4) NM_146257 1.98 5330439J01Rik cDNA 5330439J01 gene (5330439J01Rik) NM_175407 1.98 Tes testis derived transcript (Tes) NM_011570 1.98

3

D6Ertd365e zinc and ring finger 2 (Znrf2) NM_199143 1.97 Akt3 thymoma viral proto-oncogene 3 (Akt3) NM_011785 1.97 Tubb4 , beta 4 (Tubb4) NM_009451 1.97 1700001L19Rik cDNA 1700001L19 gene (1700001L19Rik) XM_127414 1.96 Arrdc4 arrestin domain containing 4 (Arrdc4) NM_025549 1.96 Dmn desmuslin (Dmn) NM_207663 1.94 Ldb2 LIM domain binding 2 (Ldb2) NM_010698 1.94 Smpd3 sphingomyelin 3, neutral NM_021491 1.94 Flrt3 fibronectin leucine rich transmembrane protein 3 NM_178382 1.94 Vsnl1 visinin-like 1 NM_012038 1.93 Ldb2 LIM domain binding 2 (Ldb2), transcript variant 1 NM_010698 1.93 Acat2 acetyl-Coenzyme A acetyltransferase 2 NM_009338 1.93 Wsb2 WD repeat and SOCS box-containing 2 NM_021539 1.93 Rab15 RAB15, member RAS oncogene family NM_134050 1.90 Brunol4 bruno-like 4, RNA binding protein (Drosophila) NM_133195 1.89 Emid2 EMI domain containing 2 NM_024474 1.89 elf1; elf3 spectrin beta 2 (Spnb2), transcript variant 1 NM_175836 1.89 3110006E14Rik cDNA 3110006E14 gene (3110006E14Rik) XM_127466 1.88 Lrrn3 leucine rich repeat protein 3, neuronal (Lrrn3) NM_010733 1.88 Slc2a6 solute carrier family 2 (facilitated glucose transporter), member 6 NM_172659 1.88 BC017634 CaM kinase-like vesicle-associated NM_145621 1.87 Lor loricrin NM_008508 1.87 Enc1 ectodermal-neural cortex 1 NM_007930 1.86 Crmp1 collapsin response mediator protein 1 NM_007765 1.86 Cobl cordon-bleu NM_172496 1.86 Sncb synuclein, beta NM_033610 1.86 Neurl neuralized-like homolog (Drosophila) NM_021360 1.85 Bach acyl-CoA 7 NM_133348 1.84 Mtap1b microtubule-associated protein 1 B NM_008634 1.84 Nudt4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 NM_027722 1.84 Aacs acetoacetyl-CoA synthetase NM_030210 1.84 Atp9a ATPase, class II, type 9A NM_015731 1.84 Stx1a syntaxin 1A ( NM_016801 1.83 Neo1 neogenin (Neo1), transcript variant 1 NM_008684 1.83 Slco3a1 solute carrier organic anion transporter family, member 3a1 NM_023908 1.83 Ncald delta NM_134094 1.83 Nsdhl NAD(P) dependent steroid dehydrogenase-like NM_010941 1.83 Arhgdig Rho GDP dissociation inhibitor (GDI) gamma NM_008113 1.83 Sqle squalene epoxidase NM_009270 1.83 Eef1a2 eukaryotic translation elongation factor 1 alpha 2 NM_007906 1.82 Syn1 synapsin I NM_013680 1.82 Prkcz C, zeta (Prkcz), transcript variant 1 NM_008860 1.82 AI593442 expressed sequence AI593442 (AI593442), transcript variant 1 NM_177907 1.82 4930420O11Rik Mus musculus microtubule associated serine/threonine kinase family XM_283179 1.82 Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter) NM_080853 1.82 Nsdhl NAD(P) dependent steroid dehydrogenase-like NM_010941 1.81 Lrfn2 leucine rich repeat and fibronectin type III domain containing 2 NM_027452 1.81

4

Atp9a ATPase, class II, type 9A NM_015731 1.81 Fdps farnesyl diphosphate synthetase NM_134469 1.81 Scn3b sodium channel, voltage-gated, type III, beta (Scn3b), transcript variant 2 NM_178227 1.81 Satb2 special AT-rich sequence binding protein 2 NM_139146 1.81 Cdkl2 -dependent kinase-like 2 (CDC2-related kinase) NM_177270 1.81 Mef2c myocyte enhancer factor 2C NM_025282 1.81 Slc6a17 solute carrier family 6 (neurotransmitter transporter), member 17 NM_172271 1.81 Gprin1 -regulated inducer of neurite outgrowth 1 NM_012014 1.80 Wdr47 WD repeat domain 47 NM_181400 1.80 Met met proto-oncogene NM_008591 1.80 Jakmip1 janus kinase and microtubule interacting protein 1 NM_178394 1.80 Chst1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 NM_023850 1.80 Acat2 acetyl-Coenzyme A acetyltransferase 2 NM_009338 1.79 D15Bwg0669e metallophosphoesterase domain containing 1 NM_172610 1.79 Nsdhl NAD(P) dependent steroid dehydrogenase-like NM_010941 1.79 Ly6h lymphocyte antigen 6 complex, H NM_011837 1.78 Igsf4b molecule 3 NM_053199 1.78 Sertad4 SERTA domain containing 4 NM_198247 1.78 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase NM_008255 1.78 Gnao1 guanine nucleotide binding protein, alpha o NM_010308 1.77 Pou3f1 POU domain, class 3, transcription factor 1 NM_011141 1.77 Phactr1 phosphatase and regulator 1 (Phactr1), transcript variant 1 NM_198419 1.77 Socs2 suppressor of cytokine signaling 2 NM_007706 1.77 Cplx1 complexin 1 NM_007756 1.77 Kndc1 kinase non-catalytic C-lobe domain NM_177261 1.76 Prkar2b protein kinase, cAMP dependent regulatory, type II beta NM_011158 1.76 Jazf1 JAZF zinc finger 1 NM_173406 1.76 Ly6h lymphocyte antigen 6 complex, locus H NM_011837 1.76 Rem2 rad and gem related GTP binding protein 2 NM_080726 1.76 Arhgap23 RIKEN cDNA 4933428G20 gene NM_021493 1.76 Idh1 1 (NADP+), soluble NM_010497 1.76 Cdkl2 cyclin-dependent kinase-like 2 (CDC2-related kinase) NM_177270 1.76 Mmd monocyte to macrophage differentiation-associated NM_026178 1.75 Coro1a coronin, actin binding protein 1A NM_009898 1.75 Doc2b double C2, beta NM_007873 1.75 6030405A18 RIKEN cDNA 6030405A18 gene NM_177854 1.74 App amyloid beta (A4) precursor protein NM_007471 1.74 Dtx4 deltex 4 homolog (Drosophila) NM_172442 1.74 Rab6b RAB6B, member RAS oncogene family NM_173781 1.74 Ssbp2 single-stranded DNA binding protein 2 NM_024186 1.74 Dnajc6 DnaJ (Hsp40) homolog, subfamily C, member 6 NM_198412 1.73 Kctd13 potassium channel tetramerisation domain containing 13 NM_172747 1.73 5430431G03Rik La ribonucleoprotein domain family, member 6 NM_026235 1.73 Kns2 light chain 1 (Klc1), transcript variant a NM_008450 1.73 Acp1 protein kinase C, beta 1 NM_008855 1.73 Arf3 ADP-ribosylation factor 3 NM_007478 1.73 Ankrd13d repeat domain 13 family, member D NM_026720 1.72 Larp6 La ribonucleoprotein domain family, member 6 NM_026235 1.72

5

Reep5 receptor accessory protein 5 NM_007874 1.72 Acot7 acyl-CoA thioesterase 7 NM_133348 1.72 Gpm6a glycoprotein m6a NM_153581 1.72 Bach2 BTB and CNC homology 2 NM_007521 1.72 Ly6h lymphocyte antigen 6 complex, locus H NM_011837 1.72 Elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 NM_010487 1.72 BC018242 cDNA sequence BC018242 NM_144935 1.71 1700086L19Rik cDNA 1700086L19 gene XM_358420 1.71 Neurod2 neurogenic differentiation 2 NM_010895 1.71 Adam23 a disintegrin and metallopeptidase domain 23 NM_011780 1.71 Dncic1 cytoplasmic 1 intermediate chain 1 NM_010063 1.71 Sv2a synaptic vesicle glycoprotein 2 a NM_022030 1.71 Rab9b RAB9B, member RAS oncogene family NM_176971 1.70 Slc6a15 solute carrier family 6 (neurotransmitter transporter), member 15 NM_175328 1.70 Fabp3 binding protein 3, muscle and heart NM_010174 1.70 Eml1 echinoderm microtubule associated protein like 1 NM_001043335 1.70 Tubb5 tubulin, beta 5 NM_011655 1.70 Dlgh4 discs, large homolog 4 NM_007864 1.70 Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit NM_021415 1.70 Siat8b ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 NM_009181 1.70 Garnl3 GTPase activating RANGAP domain-like 3 NM_178888 1.70 Atp2a2 ATPase, Ca++ transporting, , slow twitch 2 NM_009722 1.70 Enox1 ecto-NOX disulfide-thiol exchanger 1 NM_172813 1.70 Brunol6 bruno-like 6, RNA binding protein NM_175235 1.70 Ssbp2 single-stranded DNA binding protein 2 NM_024186 1.69 Rgs17 regulator of G-protein signaling 17 NM_019958 1.69 Ykt6 YKT6 homolog (S. Cerevisiae) NM_019661 1.69 Cnih3 cornichon homolog 3 (Drosophila) NM_028408 1.69 Cyb561 cytochrome b-561 NM_007805 1.68 Scg2 secretogranin II NM_009129 1.68 Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain NM_013658 1.68 AU042671 expressed sequence AU042671, transcript variant 1 XM_132325 1.68 Lphn1 latrophilin 1 NM_181039 1.68 Capn5 5 NM_007602 1.68 Ccrn4l CCR4 carbon catabolite repression 4-like (S. cerevisiae) NM_009834 1.68 Gdi1 guanosine diphosphate (GDP) dissociation inhibitor 1 NM_010273 1.68 Gdi1 guanosine diphosphate (GDP) dissociation inhibitor 1 NM_010273 1.68 Rab6 RAB6, member RAS oncogene family NM_024287 1.68 Aplp1 amyloid beta (A4) precursor-like protein 1 NM_007467 1.68 5730410E15Rik cDNA 5730410E15 gene NM_178765 1.67 Gdf10 growth differentiation factor 10 NM_145741 1.67 Trim3 tripartite motif protein 3 NM_018880 1.67 Syn1 synapsin I NM_013680 1.67 Slitrk5 SLIT and NTRK-like family, member 5 NM_029273 1.67 Mtap1b microtubule-associated protein 1 B NM_008634 1.67 Jph4 junctophilin 4 NM_177049 1.67 Rab3b RAB3B, member RAS oncogene family NM_023537 1.67 Rusc1 RUN and SH3 domain containing 1 NM_028188 1.67

6

Kns2 kinesin light chain 1 NM_008450 1.67 Ugcg UDP-glucose ceramide glucosyltransferase NM_011673 1.67 D14Ertd171e ELKS/RAB6-interacting/CAST family member 2 NM_177814 1.67 Camkk2 calcium/-dependent protein kinase kinase 2, beta NM_145358 1.67 Rhou ras homolog gene family, member U NM_133955 1.67 Pkia protein kinase inhibitor, alpha NM_008862 1.67 Tubb2b tubulin, beta 2b NM_023716 1.67 Nt5dc3 5'- domain containing 3 NM_175331 1.66 Ank3 ankyrin 3, epithelial NM_170689 1.66 B230209C24Rik RIKEN cDNA B230209C24 gene NM_177235 1.66 Rras2 related RAS viral (r-ras) oncogene homolog 2 NM_025846 1.66 Ppp1r14c 1, regulatory (inhibitor) subunit 14c NM_133485 1.66 Sms spermine synthase NM_009214 1.66 Stmn3 stathmin-like 3 NM_009133 1.66 Prkcb1 protein kinase C, beta 1 NM_008855 1.66 Npy1r neuropeptide Y receptor Y1 NM_010934 1.66 Tmem108 transmembrane protein 108 NM_178638 1.66 AI851790 expressed sequence AI851790 NM_182807 1.66 Gnao1 guanine nucleotide binding protein, alpha o NM_010308 1.65 Coro1a coronin, actin binding protein 1A NM_009898 1.65 Lss lanosterol synthase NM_146006 1.65 Uchl1 ubiquitin carboxy-terminal NM_011670 1.65 Vstm2l V-set and transmembrane domain containing 2-like NM_198627 1.65 Rgs4 regulator of G-protein signaling 4 NM_009062 1.65 Sqle squalene epoxidase NM_009270 1.65 Rbm9 RNA binding motif protein 9 NM_053104 1.65 N6amt2 N-6 adenine-specific DNA methyltransferase 2 (putative) NM_026526 1.65 Acaca acetyl-Coenzyme A carboxylase alpha XM_109883 1.65 Dpysl3 dihydropyrimidinase-like 3 NM_009468 1.65 Sema6b transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B NM_013662 1.65 Kifc2 kinesin family member C2 NM_010630 1.65 Mapk8ip1 mitogen activated protein kinase 8 interacting protein 1 NM_011162 1.65 Itpr1 inositol 1,4,5-triphosphate receptor 1 NM_010585 1.65 Dok5 docking protein 5 NM_029761 1.65 Scn3b sodium channel, voltage-gated, type III, beta NM_178227 1.64 Cplx2 complexin 2 NM_009946 1.64 Syngr3 synaptogyrin 3 NM_011522 1.64 Mtch1 mitochondrial carrier homolog 1 NM_019880 1.64 Odz2 odd Oz/ten-m homolog 2 (Drosophila) (Odz2), transcript variant 1 NM_011856 1.64 Adcy5 adenylate cyclase 5 NM_001012765 1.64 Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) NM_009616 1.64 Stxbp1 syntaxin binding protein 1 NM_009295 1.64 Gnai1 guanine nucleotide binding protein, alpha inhibiting 1 NM_010305 1.64 Gpr85 G protein-coupled receptor 85 NM_145066 1.64 Reep1 receptor accessory protein 1 NM_178608 1.64 Tbc1d9 TBC1 domain family, member 9 NM_027758 1.64 Cyp51 cytochrome P450, family 51 NM_020010 1.64 Dhx57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 NM_198942 1.64

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Hcn2 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 NM_008226 1.64 2610110G12Rik RIKEN cDNA 2610110G12 gene NM_028476 1.64 Flrt3 fibronectin leucine rich transmembrane protein 3 NM_178382 1.64 Has3 hyaluronan synthase 3 NM_008217 1.64 Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 NM_201352 1.63 C77370 expressed sequence C77370 NM_001077354 1.63 Herc2 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 NM_010418 1.63 Ptpn5 protein tyrosine phosphatase, non-receptor type 5 NM_013643 1.63 Gja9 gap junction membrane channel protein alpha 9 NM_010290 1.63 Pak1 p21 (CDKN1A)-activated kinase 1 NM_011035 1.63 Pacsin1 protein kinase C and casein kinase substrate in neurons 1 NM_011861 1.63 1110031B06Rik RIKEN cDNA 1110031B06 gene NM_144521 1.63 Dbpht2 DNA binding protein with his-thr domain NM_198866 1.63 Rnf208 ring finger protein 208 NM_176834 1.63 Klf7 Kruppel-like factor 7 NM_033563 1.63 Sobp sine oculis-binding protein homolog NM_175407 1.62 Pcsk2 proprotein convertase subtilisin/kexin type 2 NM_008792 1.62 Gm1012 G protein-coupled receptor 176 NM_201367 1.62 Foxp1 forkhead box P1 NM_053202 1.62 Snrpn SNRPN upstream reading frame NM_033174 1.62 Tubb3 tubulin, beta 3 NM_023279 1.62 Pvrl3 poliovirus receptor-related 3 (Pvrl3), transcript variant alpha NM_021495 1.62 Syp synaptophysin NM_009305 1.62 Pak3 p21 (CDKN1A)-activated kinase 3 NM_008778 1.62 Jph3 junctophilin 3 NM_020605 1.62 Acly ATP citrate NM_134037 1.61 Pclo piccolo (presynaptic cytomatrix protein) NM_011995 1.61 Pigt phosphatidylinositol glycan anchor biosynthesis, class T NM_133779 1.61 Mvd mevalonate (diphospho) decarboxylase NM_138656 1.61 Centa1 centaurin, alpha 1 NM_172723 1.61 Snph syntaphilin NM_198214 1.61 Tmem35 transmembrane protein 35 NM_026239 1.61 Stx7 syntaxin 7 NM_016797 1.61 2310022B05Rik RIKEN cDNA 2310022B05 gene NM_175149 1.61 Gnb4 guanine nucleotide binding protein, beta 4 NM_013531 1.61 B3galt3 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 NM_020026 1.61 2900011O08Rik RIKEN cDNA 2900011O08 gene NM_144518 1.61 Hrb HIV-1 Rev binding protein NM_010472 1.60 Samd14 sterile alpha motif domain containing 14 NM_146025 1.60 Lrp11 low density lipoprotein receptor-related protein 11 NM_172784 1.60 Sema4f sema domain, immunoglobulin domain (Ig), TM domain NM_011350 1.60 Sv2a synaptic vesicle glycoprotein 2 a NM_022030 1.60 Snrpn small nuclear ribonucleoprotein N (Snrpn), transcript variant 1 NM_013670 1.60 Bai3 brain-specific angiogenesis inhibitor 3 NM_175642 1.60 Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter) NM_009199 1.60 Rit2 Ras-like without CAAX 2 NM_009065 1.60 Pcdha11 alpha 1 NM_054072 1.60 Hcn3 hyperpolarization-activated, cyclic nucleotide-gated K+ 3 NM_008227 1.60

8

B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 NM_019737 1.60 Lsm14b LSM14 homolog B (SCD6, S. cerevisiae) NM_177727 1.60 Dclk3 doublecortin-like kinase 3 NM_172928 1.60 Syt5 synaptotagmin V NM_016908 1.60 Lin7b lin-7 homolog B (C. elegans) NM_011698 1.60 2900011O08Rik RIKEN cDNA 2900011O08 gene NM_144518 1.59 Ptpro protein tyrosine phosphatase, receptor type, O NM_011216 1.59 Ankrd13b ankyrin repeat domain 13b NM_172945 1.59 AI593442 expressed sequence AI593442 (AI593442), transcript variant 1 NM_177907 1.59 Map1lc3a microtubule-associated protein 1 light chain 3 alpha NM_025735 1.59 1500041B16Rik RIKEN cDNA 1500041B16 gene NM_029861 1.59 Ptpro protein tyrosine phosphatase, receptor type, O NM_011216 1.59 Ntsr1 neurotensin receptor 1 NM_018766 1.59 Mapre2 microtubule-associated protein, RP/EB family, member 2 NM_153058 1.59 Hspb3 heat shock protein 3 NM_019960 1.59 B930076A02 transmembrane protein 145 NM_183311 1.58 Sipa1l1 signal-induced proliferation-associated 1 like 1 NM_172579 1.58 Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 NM_009320 1.58 Grp gastrin releasing peptide NM_175012 1.58 Xbp1 X-box binding protein 1 NM_013842 1.58 Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 NM_007461 1.58 C3HC4 membrane-associated ring finger NM_001033262 1.58 Odz3 odd Oz/ten-m homolog 3 NM_011857 1.58 Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 NM_011875 1.58 4932409I22Rik RIKEN cDNA 4932409I22 gene NM_198614 1.58 Sgip1 SH3-domain GRB2-like (endophilin) interacting protein 1 NM_144906 1.58 E130309F12Rik RIKEN cDNA E130309F12 gene NM_178756 1.58 Slco3a1 solute carrier organic anion transporter family, member 3a1 NM_023908 1.58 Tmem28 transmembrane protein 28 NM_173446 1.58 Epb4.9 erythrocyte protein band 4.9 NM_013514 1.58 Basp1 brain abundant, membrane attached signal protein 1 NM_027395 1.58 Ube2o ubiquitin-conjugating E2O NM_173755 1.58 Pnma2 paraneoplastic antigen MA2 NM_175498 1.57 Vash2 vasohibin 2 NM_144879 1.57 Gdi1 guanosine diphosphate (GDP) dissociation inhibitor 1 NM_010273 1.57 Sh3md4 SH3 multiple domains 4 NM_172788 1.57 Cadm1 1 (Cadm1), transcript variant 3 NM_018770 1.57 Kif21a kinesin family member 21A NM_016705 1.57 Prkar1b protein kinase, cAMP dependent regulatory, type I beta NM_008923 1.57 Rab11a RAB11a, member RAS oncogene family NM_017382 1.57 Diras1 DIRAS family, GTP-binding RAS-like 1 NM_145217 1.57 BC037034 cDNA sequence BC037034 NM_153161 1.57 Gng13 guanine nucleotide binding protein 13, gamma NM_022422 1.57 Dnchc1 dynein cytoplasmic 1 heavy chain 1 NM_030238 1.57 Mcf2l mcf.2 transforming sequence-like NM_178076 1.56 Kif3a kinesin family member 3A NM_008443 1.56 Psd2 pleckstrin and Sec7 domain containing 2 NM_028707 1.56

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Rnf14 ring finger protein 14 NM_020012 1.56 A830036E02Rik RIKEN cDNA A830036E02 gene NM_010661 1.56 Mmp17 matrix metallopeptidase 17 NM_011846 1.56 Pcdh20 protocadherin 20 NM_178685 1.56 Slco3a1 solute carrier organic anion transporter family, member 3a1 NM_023908 1.56 Dok5 docking protein 5 NM_029761 1.56 Pcdh19 protocadherin 19, transcript variant 2 XM_205287 1.56 Gm440 gene model 440 NM_198620 1.56 Marcksl1 MARCKS-like 1 NM_010807 1.56 Sbk SH3-binding kinase 1 NM_145587 1.56 Rgs7 regulator of G protein signaling 7 NM_011880 1.55 Kif26b kinesin family member 26B NM_177757 1.55 Dgcr6 DiGeorge syndrome critical region gene 6 NM_010047 1.55 Marcksl1 MARCKS-like 1 NM_010807 1.55 Ppp1r13b , regulatory (inhibitor) subunit 13B NM_011625 1.55 Sfxn3 sideroflexin 3 NM_053197 1.55 A030007L17Rik RIKEN cDNA A030007L17 gene NM_026637 1.55 Mapt microtubule-associated protein tau (Mapt), transcript variant 2, NM_010838 1.55 Jup junction NM_010593 1.55 Sept5 septin 5 NM_213614 1.55 Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform NM_008914 1.55 Actl6b actin-like 6B NM_031404 1.55 Rala v-ral simian leukemia viral oncogene homolog A NM_019491 1.55 Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 NM_010010 1.55 Ttc9b tetratricopeptide repeat domain 9B NM_028417 1.55 Nav1 neuron navigator 1 NM_173437 1.55 Dnm1 1 NM_010065 1.55 2310003H01Rik RIKEN cDNA 2310003H01 gene NM_027980 1.55 9030425E11Rik RIKEN cDNA 9030425E11 gene NM_133733 1.55 Sla src-like adaptor (Sla), transcript variant 2 NM_009192 1.54 Galgt1 beta-1,4-N-acetyl-galactosaminyl 1 NM_008080 1.54 Gprasp1 G protein-coupled receptor associated sorting protein 1 NM_026081 1.54 Mkx mohawk NM_177595 1.54 1700012H17Rik RIKEN cDNA 1700012H17 gene NM_173426 1.54 Impdh1 inosine 5'-phosphate dehydrogenase 1 NM_011829 1.54 Tmem118 transmembrane protein 118 NM_172998 1.54 Sh3kbp1 SH3-domain kinase binding protein 1 NM_021389 1.54 Olfm1 olfactomedin 1 NM_019498 1.54 Casp3 caspase 3 NM_009810 1.54 Sec23a SEC23A (S. cerevisiae) NM_009147 1.54 Eno2 enolase 2, gamma neuronal NM_013509 1.54 Atp6v1g2 ATPase, H+ transporting, lysosomal V1 subunit G2 NM_023179 1.53 Mapt microtubule-associated protein tau (Mapt), transcript variant 2 NM_010838 1.53 Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 NM_009685 1.53 Mtap7d2 MAP7 domain containing 2 NM_001081124 1.53 Kcnmb4 potassium large conductance calcium-activated channel, subfamily M NM_021452 1.53 3110035E14Rik RIKEN cDNA 3110035E14 gene NM_178399 1.53 Vamp2 vesicle-associated 2 NM_009497 1.53

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Ibrdc3 IBR domain containing 3 XM_204030 1.53 Gabbr1 gamma-aminobutyric acid (GABA-B) receptor, 1 NM_019439 1.53 Cds1 CDP-diacylglycerol synthase 1 NM_173370 1.53 Thsd2 R-spondin 3 homolog (Xenopus laevis) NM_028351 1.53 Ulk2 Unc-51 like kinase 2 (C. elegans) NM_013881 1.53 Irgq immunity-related GTPase family, Q NM_153134 1.53 Nkd2 naked cuticle 2 homolog NM_028186 1.53 Cdh8 cadherin 8 NM_007667 1.53 Arpp21 cyclic AMP-regulated phosphoprotein, 21 NM_028755 1.53 Dbn1 drebrin 1 NM_019813 1.53 Iqsec3 IQ motif and Sec7 domain 3 NM_001033354 1.53 Tmem183a transmembrane protein 183A (Tmem183a), transcript variant 1 NM_020588 1.53 5230400G24Rik RIKEN cDNA 5230400G24 gene NM_029409 1.53 BC025575 cDNA sequence BC025575 NM_199200 1.53 6430598A04Rik RIKEN cDNA 6430598A04 gene NM_175521 1.53 Ptprf protein tyrosine phosphatase, receptor type, F NM_011213 1.53 Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 NM_016920 1.53 Sez6 seizure related gene 6 NM_021286 1.53 Slitrk4 SLIT and NTRK-like family, member 4 NM_178740 1.53 Arl15 ADP-ribosylation factor-like 15 NM_172595 1.53 Dpp6 dipeptidylpeptidase 6 NM_010075 1.53 Marcksl1 MARCKS-like 1 NM_010807 1.53 Kit kit oncogene NM_021099 1.52 Centa1 centaurin, alpha 1 NM_172723 1.52 Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 NM_016775 1.52 Homer1 homer homolog 1 (Drosophila) NM_152134 1.52 AU040829 expressed sequence AU040829 NM_175003 1.52 Pbp guanine nucleotide binding protein, alpha q polypeptide NM_008139 1.52 N28178 expressed sequence N28178 NM_172690 1.52 Fkbp1b FK506 binding protein 1b NM_016863 1.52 Sult4a1 sulfotransferase family 4A, member 1 NM_013873 1.52 Ephb6 Eph receptor B6 NM_007680 1.52 March6 membrane-associated ring finger (C3HC4) 6 NM_172606 1.52 Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter) NM_182993 1.52 Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 NM_178676 1.52 Gabrb1 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1 NM_008069 1.52 Homer1 homer homolog 1 (Drosophila) NM_152134 1.52 Stmn2 stathmin-like 2 NM_025285 1.52 Ppp2r1a (formerly 2A), regulatory subunit A NM_016891 1.52 Rab4b RAB4B, member RAS oncogene family NM_029391 1.52 Plk3 polo-like kinase 3 (Drosophila) NM_013807 1.52 Copeb Kruppel-like factor 6 NM_011803 1.52 Kctd10 potassium channel tetramerisation domain containing 10 NM_026145 1.52 4631426J05Rik RIKEN cDNA 4631426J05 gene NM_029935 1.52 Elovl6 ELOVL family member 6, elongation of long chain fatty acids NM_130450 1.52 Nln neurolysin (metallopeptidase M3 family) NM_029447 1.52 Ckmt1 creatine kinase, mitochondrial 1, ubiquitous NM_009897 1.52 Rabep1 rabaptin, GTPase binding effector protein 1 NM_019400 1.52

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Fcho1 FCH domain only 1 NM_028715 1.52 Rapgef5 Rap guanine nucleotide exchange factor (GEF) NM_175930 1.52 Sept6 septin 6 NM_019942 1.51 Map3k12 mitogen activated protein kinase kinase kinase 12 NM_009582 1.51 Trp53bp1 transformation related protein 53 binding protein 1 NM_013735 1.51 Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform NM_008913 1.51 Wnk2 WNK lysine deficient protein kinase 2 NM_029361 1.51 Slc25a22 solute carrier family 25 (mitochondrial carrier, glutamate), member 22 NM_026646 1.51 Dbndd1 dysbindin (dystrobrevin binding protein 1) domain containing 1 NM_028146 1.51 Bach acyl-CoA thioesterase 7 NM_133348 1.51 Mapk9 mitogen activated protein kinase 9 (Mapk9), transcript variant 1 NM_207692 1.51 Slc7a4 solute carrier family 7 (cationic amino acid transporter, y+ system) NM_144852 1.51 Syt14l synaptotagmin XVI NM_172804 1.51 Arpc5 actin related protein 2/3 complex, subunit 5 NM_026369 1.51 Pcyt1b phosphate cytidylyltransferase 1, choline, beta isoform NM_211138 1.51 Rtn4rl1 reticulon 4 receptor-like 1 NM_177708 1.51 Gabarapl1 gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1 NM_020590 1.51 Dcamkl1 doublecortin-like kinase 1 NM_019978 1.51 Ss18l1 synovial sarcoma translocation gene on 18-like 1 NM_178750 1.51 Limk1 LIM-domain containing, protein kinase NM_010717 1.51 Nlgn2 neuroligin 2 NM_198862 1.51 Rab3d RAB3D, member RAS oncogene family NM_031874 1.51 Samd10 sterile alpha motif domain containing 10 NM_172676 1.51 Gng2 guanine nucleotide binding protein (G protein), gamma 2 subunit NM_010315 1.50 Rbm3 RNA binding motif protein 3 NM_016809 1.50 Ube2e3 ubiquitin-conjugating enzyme E2E 3 NM_009454 1.50 Kifap3 kinesin-associated protein 3 NM_010629 1.50 Pld3 D family, member 3 NM_011116 1.50 Prss12 protease, serine, 12 neurotrypsin (motopsin) NM_008939 1.50 0710005M24Rik RALY RNA binding protein-like NM_178631 1.50

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