Dartmouth College Dartmouth Digital Commons Dartmouth Scholarship Faculty Work 5-11-2011 Nrt1 and Tna1-Independent Export of NAD+ Precursor Vitamins Promotes NAD+ Homeostasis and Allows Engineering of Vitamin Production Peter Belenky Dartmouth College Rebecca Stebbins Dartmouth College Katrina L. Bogan Dartmouth College Charles R. Evans University of Michigan Charles Brenner Dartmouth College Follow this and additional works at: https://digitalcommons.dartmouth.edu/facoa Part of the Medicine and Health Sciences Commons Dartmouth Digital Commons Citation Belenky, Peter; Stebbins, Rebecca; Bogan, Katrina L.; Evans, Charles R.; and Brenner, Charles, "Nrt1 and Tna1-Independent Export of NAD+ Precursor Vitamins Promotes NAD+ Homeostasis and Allows Engineering of Vitamin Production" (2011). Dartmouth Scholarship. 3006. https://digitalcommons.dartmouth.edu/facoa/3006 This Article is brought to you for free and open access by the Faculty Work at Dartmouth Digital Commons. It has been accepted for inclusion in Dartmouth Scholarship by an authorized administrator of Dartmouth Digital Commons. For more information, please contact
[email protected]. Nrt1 and Tna1-Independent Export of NAD+ Precursor Vitamins Promotes NAD+ Homeostasis and Allows Engineering of Vitamin Production Peter Belenky1, Rebecca Stebbins1, Katrina L. Bogan1,2, Charles R. Evans3, Charles Brenner1,2* 1 Departments of Genetics and Biochemistry and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 2 Departments of Biochemistry and Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, 3 Molecular Phenotyping Core, University of Michigan Nutrition and Obesity Research Center, Ann Arbor, Michigan, United States of America Abstract NAD+ is both a co-enzyme for hydride transfer enzymes and a substrate of sirtuins and other NAD+ consuming enzymes.