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Ce O-Giut'e , O ENT .,rNS~tC'hN CODE DOCUMEN N A L p~ -~ A~ A d' ~ m cnd cnt u x bcr CO PROJECT D E~ DAT Cj Oj,000 0cOne .. *t:&for .Science -and. Technbology fi:.- 936-4178 *A'44 ,."..;,"'.......OFFICE .T 870 , .. .. .. 5.... PROJECT TTLE (maxi... chw=,acctrm) 2 iofgicutu>R'A"SISTAIC COM.(PLETION DATE (PACD) *'" 7' ,N ED DATE OF.OB..GATION a > ....... 9. iti iF ......... ~ ', '"~'>"'-8. COSTS 5;000 OR EQUI'VALENT S1-'... A. FUNDING SOURCE -FRTT - I,- 1LIFE OF PROJECT B C.L/C D. Total A--L-FX ce o-giut'e ,"0 o 0...... ' F. L/C C .ToaIW < AM Appr ri:cd Total . - E,p....r.......~a1 k~'c ines h u Bi t c ,(Grant)_ t$870$ , 87 V8,870.n8, 870 ) () ( 870 8 ;7 , H 5 '870 ) () (~ ; ' th r . Missions, Regionalb­ :¢ x '.: Ua 2.,Bureaus & AID :4 . :'" :;0 0 • . W ~'0030 " '4...T3-;.'T"A L S - , Host Country . .... ... 3 003,0 Other Donor~s) .. ,d..a .. ,") . 1.b.Lo..w r4,..3.1 TOTT AALL S " . .. ."..... .. ......" 70 ". 3,870 8 ,870 10 1 9. SCHEDULE OF All)t, FUNDING ($000)Q..u ....c r r . 'A.4.S N PURPOSE TC CODEY D. OBLIGATIONS TO DATE P -AibEC OETITISU.PS E. AMOUNT ACTONAPPROVEDFF F. LIFPROJCT CODE 1.Grant 2. Loan 1.Grn.,2- Lo= 1. Grnt IARDN II 1 078 - $870 2. Loan 1.GG t 2.Lo =n $5,000 $5,870, .(4) ' TO T A LS , . ... 5,000 .... p10. SECONDARY 5..870... TECHNICAL CODES (mAxim um,,8 codes of13 po;ntio-s each) 11. SECONDARY PURYOSE CODi 112. SPECIA CONCERNS CODES (maximum 7 codes of4posisoru eaCh) A.Code I R/AG .XII R/ED B.Amoii i 7 I,5 1.,5100 j $,0 13. PROJECT PFUR-POS E (maximum 480 chaacters).. To use the biotcchnologicai. skills of thle U.S. scientific (2) collaboration.... community in ..... •.....with LDC, scientists : - ..- : , . n r to develop and v iteste ino -ucontainmetnw .. - : ' Or improved vaccines for the cointrol of r'inderpest a'c" amoi an baeiss 14. SCHEDULEVALUATIONS ,15. SOURCE/ORIGIN OF GOODS A.ND SERVICES 4 ?OYYM M]YY 1ni10 8 9 d1 29 4 Fnl1 2 000 O~ ~Lcl Othe(Sptc*if).__ 1b. A1ME.NDMENTS(NATLTRE OF CH-ANGE PROPOSED (This is page)I of a pagrPA mcm dm m .) The purpose of this amendment is to increase the authorized life $5,000,000 to expand of project, cost, by the purpose for the development and containment improved vaccines testing of new 'or bIr the control .of~anaplasmosis,, and oblgaio babesiosis, extend the .final year of, 0tFY 1992, and the PACD to 9/30/93, .missions, regional and provide. for up to $3,000,000 for bureais, arid other~ADWofc~t ind~1atdatvte L-8.DATE DOCT.ThENT RECEIVED 17.E AYR nIn iiA.?RVD r D-~U, AJW, OR FOR,AJI)M DOCU M~ENT:!*IlA­ BY ', DATE OFD1DITRB no,, d '' : '. Date Sincd •,';i? ! - : ' .;:..?',.... /' . ':...:iJ ,,,-. -'.i:..:.!; !-;C~h "" , .'" ". " o " . '-','J': -" 4, :,::':-i\:.;::::: iF : ." : ";;." - ' Agu nc , D i r ctri or .I&J .... DO YY*,- LM~ DD -YY' .. .... .,. ... 0O PROJECT AUTHORIZATION AMENDMENT ENTITY: Bureau for Science and Technology PROJECT TITLE: Improved Animal Vaccines through Biotechnology Amendment No. I 1. Pursuant to Section 103 of the Foreign Assistance Act of 1961, as amended, the Improved Animal Vaccine through Biotechnology project which is centrally funded was authorized on June 27, 1986. The authorization is hereby amended as follows: - The centrally funded planned obligation level is increased by $5,000,000 in grant tunds to $5,870,0U0 for developing and testing in containment facilities new or improved vaccines for the control of anaplasmosis and babesiosis; - Up to $3,UU,000 of additional funding may be provided by missions, regional bureaus, and other AID/W offices during the extended period for adapted research, training, networking and technology transfer. - The authorized final year of obligation is extended to FY 1992; and - The authorized project assistance completion date is extended to September 30, 1993. 2. The authorization cited above remains in force except as hereby amended. Duane Acker Agency Director for Food and Agriculture Bureau for Science and Technology Date _ __ _ _ Clearances: S&T/AGR, D . Bathrick Date S&T/AGR, H. Hortik _ Date - S&T/AGR, E. Roche- Date__-/ S&T/PO, G. Gower ____'_Date !15/J[j G:C/r4fPS. Ti/sa C/KDate WANG: 3374f:S&T/AGR/AP:MMozYniSki/FPochfe': /1( X7 ACTION MEMORANDUM FOR THE AGENCY DIRECTOR FOR FOOD AND AGRICULTURE, BUREAU FOP SCIENCE AN! TLCHNOLOGY FROM: S&T/AGR, David D. Bathr ic~ SUBJECT: Authorization Amendment of the Improved Animal Vaccine through Biotechnology Project (936-4178) Problem: Your approval is required to amend the Improved Animal Vaccine through Biotechnology project to: 1) expand the purpose to include development of vaccines for control of two additional livestock diseases; 2) extend the authorized project assistance completion date (PACD) to September 30, 1993 and the final fiscal year of obligation to FY 1992; 3) increase the planned obligation level by $5,000,000 to $5,870,000 to be provided by S&T/AGR; and 4) add up to $3,000,000 of additional mission, regional bureau and other AID/W funds to be obligated by delivery orders issued against a companion basic ordering agreement (BOA). Discussion: The project was originally authori'.ec ia . for three years to terminate August 31, 1989 with a life-of-project cost of $870,000. The project currently is implemented through a cooperative agreement (CA) with the University of California (Davis) to develop an effective infectious virus recombinant vaccine to eradicate rinderpest. We plan to E'ward a five-year CA for $5,000,000 to develop vaccines for the control of anaplasmosis and babesiosis, but we need to amend the original authorization and update the project documentation in order to do so. The CA will be awarded pursuant to competitive procedures. This amendment will increase the authorized life of project cost by $5,000,000; expand the purpose to include te development and containment testing of new or improved vaccines for the control of anaplasmosis and babesiosis; and extend the final year of obligation to FY 1992 and the PACD to September 30, 1993. It will also provide for up to $3,000,000 for missions, regional bureaus, and other AID/W offices to fund related activities under a companion BOA which will be fed directly back into the recipient's research agenda, design, curricula, and teaching materials to be developed under the CA. S&T/AGR's contribution will provide for: i) developing the vaccine(s) and testing in containment facilities on a limited number of animals; 2) disseminating the scientific findings to the LDCs; 3) training LDC scientists at the technical, graduate and postdoctoral level and providing in-service and on-the-job training to technicians and scientists; and 4) establishing a network of information exchange among participating scientists in both developed and developing countries. - 2 - The vaccines to be developed will provide a simple inexpensive way to provide immunity to livestock diseases which cause death and reduced productivity resulting in total losses worldwide of over $1.0 billion annually. These vaccines will not require syringes or refrigeration, but will be applied by scarring the skin and can even be produced on the farm by harvesting the scabs on recently vaccinated animals. Special orders funded by the missions, regional bureaus, and other AID/W offices under the BOA will provide for operational and adaptive research in LDCs, training activities, and technical assistance. The decision to fund the development of vaccine(s) for anaplasmosis and babesiosis is based primarily on the National Science Foundation panel's 1985 report on Vaccine Development for Tropical Animal Diseases. In that report, it was recommended that A.I.D. support research on hemoparasitic diseases such as anaplasmosis, babesiosis, heartwater and theileriosis (East Coast Fever). We selected anaplasmosis and babesiosis as the vaccine development is further along than for heartwater. (Iii addition, the Bureau for Africa is funding heartwater research.) The vaccine(s) for theileriosis is being developed by the International Laboratory for Research on Animal Diseases. The chances for the development of vaccines for anaplasmosis during the first year and babesiosis during the second year are very high according to scientists currently working in this field. Large-scale field testing of the vaccine(s), which is necessary prior to utilization of the vaccine(s), is not included in this phase of the project. At the present time, a complete environmental assessment reviewed by USDA, Animal and Plant Health Inspection Service, is required before such field testing may be initiated. The issues and funding of field testing would have to be addressed if a follow-on project is developed. Sector Council Endorsement: On April 1, 1987 the members of the Sector Council for Agriculture endorsed this amendment to the project paper; copy attached as Tab C. Agency Policy: This project amendment is consistent with the Agency's current emphasis for the Section 103 account to increase incomes of the poor and expand the availability and consumption of food while maintaining and enhancing the natural resource base. The activities proposed to be carried out under the CA can strengthen national institutional capabilities - 3 ­ through education, policy dialogue, and human resources development. In addition, this project amendment has the potential of increasing the foreign exchange earnings from the sale of livestock products on the world market. Justification to Congress: This action will require a congressional notification as the project was not included in FY 1987 CP.
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