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3 Embryology and Development
BIOL 6505 − INTRODUCTION TO FETAL MEDICINE 3. EMBRYOLOGY AND DEVELOPMENT Arlet G. Kurkchubasche, M.D. INTRODUCTION Embryology – the field of study that pertains to the developing organism/human Basic embryology –usually taught in the chronologic sequence of events. These events are the basis for understanding the congenital anomalies that we encounter in the fetus, and help explain the relationships to other organ system concerns. Below is a synopsis of some of the critical steps in embryogenesis from the anatomic rather than molecular basis. These concepts will be more intuitive and evident in conjunction with diagrams and animated sequences. This text is a synopsis of material provided in Langman’s Medical Embryology, 9th ed. First week – ovulation to fertilization to implantation Fertilization restores 1) the diploid number of chromosomes, 2) determines the chromosomal sex and 3) initiates cleavage. Cleavage of the fertilized ovum results in mitotic divisions generating blastomeres that form a 16-cell morula. The dense morula develops a central cavity and now forms the blastocyst, which restructures into 2 components. The inner cell mass forms the embryoblast and outer cell mass the trophoblast. Consequences for fetal management: Variances in cleavage, i.e. splitting of the zygote at various stages/locations - leads to monozygotic twinning with various relationships of the fetal membranes. Cleavage at later weeks will lead to conjoined twinning. Second week: the week of twos – marked by bilaminar germ disc formation. Commences with blastocyst partially embedded in endometrial stroma Trophoblast forms – 1) cytotrophoblast – mitotic cells that coalesce to form 2) syncytiotrophoblast – erodes into maternal tissues, forms lacunae which are critical to development of the uteroplacental circulation. -
Reproductive System, Day 2 Grades 4-6, Lesson #12
Family Life and Sexual Health, Grades 4, 5 and 6, Lesson 12 F.L.A.S.H. Reproductive System, day 2 Grades 4-6, Lesson #12 Time Needed 40-50 minutes Student Learning Objectives To be able to... 1. Distinguish reproductive system facts from myths. 2. Distinguish among definitions of: ovulation, ejaculation, intercourse, fertilization, implantation, conception, circumcision, genitals, and semen. 3. Explain the process of the menstrual cycle and sperm production/ejaculation. Agenda 1. Explain lesson’s purpose. 2. Use transparencies or your own drawing skills to explain the processes of the male and female reproductive systems and to answer “Anonymous Question Box” questions. 3. Use Reproductive System Worksheets #3 and/or #4 to reinforce new terminology. 4. Use Reproductive System Worksheet #5 as a large group exercise to reinforce understanding of the reproductive process. 5. Use Reproductive System Worksheet #6 to further reinforce Activity #2, above. This lesson was most recently edited August, 2009. Public Health - Seattle & King County • Family Planning Program • © 1986 • revised 2009 • www.kingcounty.gov/health/flash 12 - 1 Family Life and Sexual Health, Grades 4, 5 and 6, Lesson 12 F.L.A.S.H. Materials Needed Classroom Materials: OPTIONAL: Reproductive System Transparency/Worksheets #1 – 2, as 4 transparencies (if you prefer not to draw) OPTIONAL: Overhead projector Student Materials: (for each student) Reproductive System Worksheets 3-6 (Which to use depends upon your class’ skill level. Each requires slightly higher level thinking.) Public Health - Seattle & King County • Family Planning Program • © 1986 • revised 2009 • www.kingcounty.gov/health/flash 12 - 2 Family Life and Sexual Health, Grades 4, 5 and 6, Lesson 12 F.L.A.S.H. -
Female Reproductive System External Female Reproductive Organs Internal Female Reproductive Organs Menstrual Cycle
Prevention and Recognition of Obstetric Fistula Training Package Module 3: Female Reproductive System External female reproductive organs Internal female reproductive organs Menstrual cycle • Menstruation usually starts when a girl is between 11-15 years of age (menarche) and continues until 50-60 years of age (menopause) • Monthly cycle if a woman is not pregnant or breastfeeding (can also be affected by some methods of family planning) • Controlled by hormone cycles – Follicular stimulating hormone (FSH) and Luteinizing hormone (LH) from the pituitary gland – Estrogen and progesterone from the ovaries • After the egg is released from the ovary (ovulation) if there is no fertilization with sperm, there is a discharge of blood and mucous from the uterus and the cycle repeats Changes during pregnancy • A woman can get pregnant if she has sex during or near the time of ovulation • Symptoms of pregnancy women may notice: missed menstruation, soreness and enlargement of breasts, nausea, frequent urination and fatigue • As the fetus grows inside the uterus, it stretches and extends above the pelvic bones Impact of nutrition on reproduction • Inadequate nutrition interferes with physical growth – height and weight – of children • Young women who had inadequate nutrition as children may be short in stature, undernourished and have pelvic bones not well developed for pregnancy and childbirth • Under-nutrition can also interfere with reproductive hormones and increase risk of anemia. Women who are undernourished may not have normal menstrual cycles and may have difficulty getting pregnancy and staying healthy during pregnancy. -
The Effects of Alcohol in Newborns Efeitos Do Álcool No Recém-Nascido
REVIEW The effects of alcohol in newborns Efeitos do álcool no recém-nascido Maria dos Anjos Mesquita* ABSTRACT alcoólicas leva a prejuízos individuais, para a sua família e para The purpose of this article was to present a review of the effects toda a sociedade. Apesar disso, a dificuldade do seu diagnóstico e of alcohol consumption by pregnant mothers on their newborn. a inexperiência dos profissionais de saúde faz com que o espectro Definitions, prevalence, pathophysiology, clinical features, diagnostic dessas lesões seja pouco lembrado e até desconhecido. As lesões criteria, follow-up, treatment and prevention were discussed. A causadas pela ação do álcool no concepto são totalmente prevenidas search was performed in Medline, LILACS, and SciELO databases se a gestante não consumir bebidas alcoólicas durante a gestação. using the following terms: “fetus”, “newborn”, “pregnant woman”, Assim, é fundamental a detecção das mulheres consumidoras “alcohol”, “alcoholism”, “fetal alcohol syndrome”, and “alcohol- de álcool durante a gravidez e o desenvolvimento de programas related disorders”. Portuguese and English articles published from específicos de alerta sobre as consequências do álcool durante a 2000 to 2009 were reviewed. The effects of alcohol consumed by gestação e amamentação. pregnant women on newborns are extremely serious and occur frequently; it is a major issue in Public Health worldwide. Fetal alcohol Descritores: Bebidas alcoólicas/efeitos adversos; Feto; Recém-nascido; spectrum disorders cause harm to individuals, their families, and the Síndrome alcoólica fetal; Transtornos relacionados ao uso de álcool entire society. Nevertheless, diagnostic difficulties and inexperience of healthcare professionals result in such damage, being remembered rarely or even remaining uncovered. -
Gastrulation
Embryology of the spine and spinal cord Andrea Rossi, MD Neuroradiology Unit Istituto Giannina Gaslini Hospital Genoa, Italy [email protected] LEARNING OBJECTIVES: LEARNING OBJECTIVES: 1) To understand the basics of spinal 1) To understand the basics of spinal cord development cord development 2) To understand the general rules of the 2) To understand the general rules of the development of the spine development of the spine 3) To understand the peculiar variations 3) To understand the peculiar variations to the normal spine plan that occur at to the normal spine plan that occur at the CVJ the CVJ Summary of week 1 Week 2-3 GASTRULATION "It is not birth, marriage, or death, but gastrulation, which is truly the most important time in your life." Lewis Wolpert (1986) Gastrulation Conversion of the embryonic disk from a bilaminar to a trilaminar arrangement and establishment of the notochord The three primary germ layers are established The basic body plan is established, including the physical construction of the rudimentary primary body axes As a result of the movements of gastrulation, cells are brought into new positions, allowing them to interact with cells that were initially not near them. This paves the way for inductive interactions, which are the hallmark of neurulation and organogenesis Day 16 H E Day 15 Dorsal view of a 0.4 mm embryo BILAMINAR DISK CRANIAL Epiblast faces the amniotic sac node Hypoblast Primitive pit (primitive endoderm) faces the yolk sac Primitive streak CAUDAL Prospective notochordal cells Dias Dias During -
Human Blastocyst Morphological Quality Is Significantly Improved In
Human blastocyst morphological quality is significantly improved in embryos classified as fast on day 3 (R10 cells), bringing into question current embryological dogma Martha Luna, M.D.,a,b Alan B. Copperman, M.D.,a,b Marlena Duke, M.Sc.,a,b Diego Ezcurra, D.V.M.,c Benjamin Sandler, M.D.,a,b and Jason Barritt, Ph.D.a,b a Mount Sinai School of Medicine, Department of Obstetrics and Gynecology, Department of Reproductive Endocrinology and Infertility, and b Reproductive Medicine Associates of New York, New York, New York; and c EMD Serono, Rockland, Massachusetts Objective: To evaluate developmental potential of fast cleaving day 3 embryos. Design: Retrospective analysis. Setting: Academic reproductive center. Patient(s): Three thousand five hundred twenty-nine embryos. Intervention(s): Day 3 embryos were classified according to cell number: slow cleaving: %6 cells, intermediate cleaving: 7–9 cells, and fast cleaving: R10 cells, and further evaluated on day 5. The preimplantation genetic diagnosis (PGD) results of 43 fast cleaving embryos were correlated to blastocyst formation. Clinical outcomes of transfers involving only fast cleaving embryos (n ¼ 4) were evaluated. Main Outcome Measure(s): Blastocyst morphology correlated to day 3 blastomere number. Relationship between euploidy and blastocyst formation of fast cleaving embryos. Implantation, pregnancy (PR), and birth rates resulting from fast embryo transfers. Result(s): Blastocyst formation rate was significantly greater in the intermediate cleaving (72.7%) and fast cleav- ing (54.2%) groups when compared to the slow cleaving group (38%). Highest quality blastocysts were formed significantly more often in the fast cleaving group. Twenty fast cleaving embryos that underwent PGD, formed blastocysts, of which 45% (9/20) were diagnosed as euploid. -
FASD Effects of Alcohol on a Fetus
EFFECTS OF ALCOHOL ON A FETUS “Of all the substances of abuse (including cocaine, heroin, and marijuana), alcohol produces by far the most serious neurobehavioral effects in the fetus.” —Institute of Medicine Report to Congress, 19961 Prenatal exposure to alcohol can damage a fetus at any time, causing problems that persist throughout the individual’s life. There is no known safe level of alcohol use in pregnancy. WHAT IS THE SCOPE OF THE PROBLEM? identified in virtually every part of the body, including the brain, face, eyes, ears, heart, kidneys, and bones. No Alcohol is one of the most dangerous teratogens, which single mechanism can account for all the problems that are substances that can damage a developing fetus.1 Every alcohol causes. Rather, alcohol sets in motion many time a pregnant woman has a drink, her unborn child processes at different sites in the developing fetus: has one, too. Alcohol, like carbon monoxide from cigarettes, passes easily through the placenta from the • Alcohol can trigger cell death in a number of ways, mother's bloodstream into her baby's blood (See Figure causing different parts of the fetus to develop abnormally. 1)—and puts her fetus at risk of having a fetal alcohol • Alcohol can disrupt the way nerve cells develop, travel spectrum disorder (FASD). The blood alcohol level to form different parts of the brain, and function. (BAC) of the fetus becomes equal to or greater than the blood alcohol level of the mother. Because the fetus • By constricting the blood vessels, alcohol interferes with cannot break down alcohol the way an adult can, its BAC blood flow in the placenta, which hinders the delivery 2 remains high for a longer period of time. -
Stages of Embryonic Development of the Zebrafish
DEVELOPMENTAL DYNAMICS 2032553’10 (1995) Stages of Embryonic Development of the Zebrafish CHARLES B. KIMMEL, WILLIAM W. BALLARD, SETH R. KIMMEL, BONNIE ULLMANN, AND THOMAS F. SCHILLING Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403-1254 (C.B.K., S.R.K., B.U., T.F.S.); Department of Biology, Dartmouth College, Hanover, NH 03755 (W.W.B.) ABSTRACT We describe a series of stages for Segmentation Period (10-24 h) 274 development of the embryo of the zebrafish, Danio (Brachydanio) rerio. We define seven broad peri- Pharyngula Period (24-48 h) 285 ods of embryogenesis-the zygote, cleavage, blas- Hatching Period (48-72 h) 298 tula, gastrula, segmentation, pharyngula, and hatching periods. These divisions highlight the Early Larval Period 303 changing spectrum of major developmental pro- Acknowledgments 303 cesses that occur during the first 3 days after fer- tilization, and we review some of what is known Glossary 303 about morphogenesis and other significant events that occur during each of the periods. Stages sub- References 309 divide the periods. Stages are named, not num- INTRODUCTION bered as in most other series, providing for flexi- A staging series is a tool that provides accuracy in bility and continued evolution of the staging series developmental studies. This is because different em- as we learn more about development in this spe- bryos, even together within a single clutch, develop at cies. The stages, and their names, are based on slightly different rates. We have seen asynchrony ap- morphological features, generally readily identi- pearing in the development of zebrafish, Danio fied by examination of the live embryo with the (Brachydanio) rerio, embryos fertilized simultaneously dissecting stereomicroscope. -
Developmental Rate and Behavior of Early Life Stages of Bighead Carp and Silver Carp
Developmental Rate and Behavior of Early Life Stages of Bighead Carp and Silver Carp Scientific Investigations Report 2011–5076 U.S. Department of the Interior U.S. Geological Survey Cover images. Left to right (top) silver carp embryo at morula stage, silver carp embryo at olfactory placode stage, silver carp embryo at otolith appearance stage, (bottom) silver carp larvae at gill filament stage, silver carp larvae at one-chamber gas bladder stage. Developmental Rate and Behavior of Early Life Stages of Bighead Carp and Silver Carp By Duane C. Chapman and Amy E. George Scientific Investigations Report 2011–5076 U.S. Department of the Interior U.S. Geological Survey U.S. Department of the Interior KEN SALAZAR, Secretary U.S. Geological Survey Marcia K. McNutt, Director U.S. Geological Survey, Reston, Virginia: 2011 For more information on the USGS—the Federal source for science about the Earth, its natural and living resources, natural hazards, and the environment, visit http://www.usgs.gov or call 1–888–ASK–USGS. For an overview of USGS information products, including maps, imagery, and publications, visit http://www.usgs.gov/pubprod To order this and other USGS information products, visit http://store.usgs.gov Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Although this report is in the public domain, permission must be secured from the individual copyright owners to reproduce any copyrighted materials contained within this report. Suggested citation: Chapman, D.C., George, A.E., 2011, Developmental rate and behavior of early life stages of bighead carp and silver carp: U.S. -
Glossary of Common MCH Terms and Acronyms
Glossary of Common MCH Terms and Acronyms General Terms and Definitions Term/Acronym Definition Accountable Care Organizations that coordinate and provide the full range of health care services for Organization individuals. The ACA provides incentives for providers who join together to form such ACO organizations and who agree to be accountable for the quality, cost, and overall care of their patients. Adolescence Stage of physical and psychological development that occurs between puberty and adulthood. The age range associated with adolescence includes the teen age years but sometimes includes ages younger than 13 or older than 19 years of age. Antepartum fetal Fetal death occurring before the initiation of labor. death Authorization An act of a legislative body that establishes government programs, defines the scope of programs, and sets a ceiling for how much can be spent on them. Birth defect A structural abnormality present at birth, irrespective of whether the defect is caused by a genetic factor or by prenatal events that are not genetic. Cost Sharing The amount an individual pays for health services above and beyond the cost of the insurance coverage premium. This includes co-pays, co-insurance, and deductibles. Crude birth rate Number of live births per 1000 population in a given year. Birth spacing The time interval from one child’s birth until the next child’s birth. It is generally recommended that at least a two-year interval between births is important for maternal and child health and survival. BMI Body mass index (BMI) is a measure of body weight that takes into account height. -
If You Are Pregnant: INFORMATION on FETAL DEVELOPMENT, ABORTION and ALTERNATIVES August 2019
If You Are Pregnant: INFORMATION ON FETAL DEVELOPMENT, ABORTION AND ALTERNATIVES August 2019 IF YOU ARE PREGNANT: INFORMATION ON FETAL DEVELOPMENT, ABORTION AND ALTERNATIVES If You Are Pregnant: Information on Fetal Development, Abortion and Alternatives Resources used by the Minnesota Department of Health for this publication are Human Embryology and Developmental Biology, Fifth Edition, 2014; Larsen’s Human Embryology, Fifth Edition, 2014; The Developing Human, 10th Edition, 2016; and In the Womb, 2006. The photographs in this booklet are credited to Lennart Nilsson/TT Images and are used by permission; except for week 38 copyright Minnesota Department of Health. The illustrations found throughout this booklet were created by Peg Gerrity, Houston, Texas. Copyright: http://www.peggerrity.com. Minnesota Department of Health Division of Child and Family Health PO Box 64882 St. Paul, MN 55164-0882 651-201-3580 Women's Right to Know (https://www.health.state.mn.us/people/wrtk/index.html) Upon request, this material will be made available in an alternative format such as large print, Braille or audio recording. Printed on recycled paper. 2 IF YOU ARE PREGNANT: INFORMATION ON FETAL DEVELOPMENT, ABORTION AND ALTERNATIVES Contents If You Are Pregnant: INFORMATION ON FETAL DEVELOPMENT, ABORTION AND ALTERNATIVES............................................................................................................................. 1 Introduction ............................................................................................................................... -
The Protection of the Human Embryo in Vitro
Strasbourg, 19 June 2003 CDBI-CO-GT3 (2003) 13 STEERING COMMITTEE ON BIOETHICS (CDBI) THE PROTECTION OF THE HUMAN EMBRYO IN VITRO Report by the Working Party on the Protection of the Human Embryo and Fetus (CDBI-CO-GT3) Table of contents I. General introduction on the context and objectives of the report ............................................... 3 II. General concepts............................................................................................................................... 4 A. Biology of development ....................................................................................................................... 4 B. Philosophical views on the “nature” and status of the embryo............................................................ 4 C. The protection of the embryo............................................................................................................... 8 D. Commercialisation of the embryo and its parts ................................................................................... 9 E. The destiny of the embryo ................................................................................................................... 9 F. “Freedom of procreation” and instrumentalisation of women............................................................10 III. In vitro fertilisation (IVF).................................................................................................................. 12 A. Presentation of the procedure ...........................................................................................................12