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(12) United States Patent (10) Patent No.: US 9,352,008 B2 Rabovsky Et Al US0093.52008B2 (12) United States Patent (10) Patent No.: US 9,352,008 B2 Rabovsky et al. (45) Date of Patent: May 31, 2016 (54) DIETARY SUPPLEMENTS AND METHODS 6,344,220 B1 2/2002 Rose etal FORTREATING PAN AND INFLAMMATION 6,358,526 B1 3/2002 Mergens et al. 6,713,096 B2 3/2004 Cho 7,138,149 B2 11/2006 Cho (75) Inventors: Alexander B. Raboysky, Idaho Falls, ID 2003. O194435 A1 10, 2003 Mercati (US); Jeremy Ivie, Ammon, ID (US); 2007. O154575 A1 7, 2007 Shimoda et al. Stephanie Nielson, Idaho Falls, ID (US) 2009,0252796 A1 10, 2009 Mazed et al. 2010, 0021533 A1 1/2010 Mazed et al. (73) Assignee: Melaleuca, Inc., Idaho Falls, ID (US) FOREIGN PATENT DOCUMENTS Notice: Subject to any disclaimer, the term of this (*) KR 10-1998-0025262 7, 1998 patent is extended or adjusted under 35 KR 10-2002-0024127 3, 2002 U.S.C. 154(b) by 1084 days. KR 10-0415826 1, 2004 KR 2004O79393 A * 9, 2004 (21) Appl. No.: 12/854,948 KR 10-0858768 9, 2008 WO WOO115553 A1 * 3, 2001 Filed: Aug. 12, 2010 WO WOO152841 A1 * T 2001 (22) WO WO2006/093.793 9, 2006 (65) Prior Publication Data OTHER PUBLICATIONS US 2011 FOO38962 A1 Feb. 17, 2011 Levy, Asa et al. BMC Pharmaology (2006); 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with Related U.S. Application Data Freund's adjuvant (6): 1-8.* Kumar, Vetal. Indian.JPhysiol Pharmacol. Apr. 2002; 46(2): 209-17. (60) Provisional application No. 61/233,215, filed on Aug. Biodegradable microspheres of curcumin for treatment of inflamma 12, 2009. tion. Abstract. Levy, Asa et al. BMC Pharmaology (2006); 6-Shogaol reduced (51) Int. C. chronic inflammatory response in the knees of rats treated with com A6 IK36/85 (2006.01) plete Freund's adjuvant. (6): 1-8.* A6 IK 36/232 (2006.01) Funk, J et al. J Nat Prod: (2006) 69: 351-355. Turmeric Extracts Containing Curcuminoids Prevent Experimental Rheumatoid Arthri A636/73 (2006.01) tis. A6 IK36/82 (2006.01) Authorized Officer K. Kim. International Preliminary Reporton Pat A6 IK36/906 (2006.01) entability in International Application No. PCT/US2010/045260, A6 IK36/9066 (2006.01) dated Apr. 21, 2011, 7 pages. A2.3L I/30 (2006.01) Authorized Officer K. Kim. International Search Report and Written U.S. C. Opinion in International Application No. PCT/US2010/045260, (52) dated Apr. 21, 2011, 10 pages. CPC ............. A61K 36/232 (2013.01); A23L 1/3002 Altman et al., “Effects of aginger extract on knee pain inpatients with (2013.01); A61K 36/185 (2013.01); A61 K osteoarthritis.” Arthritis Rheum., 2001, 44:2531-2538. 36/73 (2013.01); A23 V 2002/00 (2013.01) Bachmeier et al., “Curcumin downregulates the inflammatory (58) Field of Classification Search cytokines CXCL1 and -2 in breast cancer cells via NFkB.” Carcinogenesis, 2008, 29(4) 779-789, Advance Access publication CPC ... A61K 36/185; A61K 36/232; A61K 36/73; Nov. 13, 2007. A61K 36/82: A61K 36/906; A61K 36/9066 Bliddal et al., “A randomized, placebo-controlled, cross-over study USPC .......................................... 424/725,729, 756 of ginger extracts and ibuprofen in osteoarthritis.” Osteoarthritis See application file for complete search history. Cartilage, 2000, 8:9-12. Broncelet al., “Effect of anthocyanins from Aronia melanocarpa on (56) References Cited blood pressure, concentration of endothelin-1 and lipids in patients with metabolic syndrome'. Pol. Merkur Lekarski. 2007, 23:116 U.S. PATENT DOCUMENTS 119. Choi et al., “Antinociceptive profiles of crude extract from roots of 3,615,721 A 10, 1971 Silberman Angelica gigas NAKAI in various pain models. Biol. Pharm. Bull. 3,758,682 A 9, 1973 Huber et al. 2003. 26:1283-1288. 4,393,085 A 7/1983 Spradlin et al. 4,698,360 A 10/1987 Masquelier (Continued) 4,737,364 A 4, 1988 Kalogris 5,009,891 A 4, 1991 Niwa et al. Primary Examiner — Chris R Tate 5,308,627 A 5/1994 Umbdenstock, Jr. 5,387,422 A 2f1995 Handel et al. (74) Attorney, Agent, or Firm — Fish & Richardson P.C. 5,565.435 A 10/1996 Yoneyama et al. 5,567,424 A 10/1996 Hastings (57) ABSTRACT 5,569,458 A 10/1996 Greenberg 5,589, 182 A 12/1996 Tashiro et al. The document provides compositions such as dietary Supple 5,626,849 A 5/1997 Hastings et al. ments. Such compositions can be used to reduce pain, inflam 5,904,924 A 5/1999 Gaynor et al. mation, stiffness, and/or discomfort associated with inflam 5.948,443 A 9/1999 Riley et al. matory conditions such as arthritis. The document also 5,976,568 A 11/1999 Riley 6,030,621 A 2/2000 De Long et al. provides methods for reducing pain, inflammation, stiffness, 6,054,128 A 4/2000 Wakat and/or discomfort associated with inflammatory conditions 6,210,679 B1 4/2001 Bailey et al. 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