Instructions for At-Home Collection of Miscarriage Tissue

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Instructions for at-home collection of miscarriage tissue If you’re experiencing a miscarriage at home and you are in a situation where you can collect the products that were miscarried, your doctor may want to perform additional tests, including chromosome testing, on this sample. When you have a miscarriage, the fetus, amniotic sac, and placenta, along with a large amount of blood, will be expelled. Less than 8 weeks More than 8 weeks If you are less than 8 weeks pregnant when the If you have reached 8 to 10 weeks, more tissue miscarriage occurs, the expelled tissue will look will be expelled which can resemble large blood no different from heavy menstrual bleeding. clots, possibly some pinkish/grayish material, or even a discernible sac. The sample should be collected in a sterile, or as clean as possible, container. This container can be a new Ziploc bag, plastic container (such as Tupperware) or an Anora collection cup if you have a kit available. It may be helpful to use a medical basin or a colander under the toilet seat to catch the products. If the tissue falls into the toilet, you can remove it and place it into the container. If you know you are going to have a miscarriage, Natera can supply you with a Anora kit that contains a collection cup for the sample. You may have already received this kit from your doctor’s office. If you are unable to bring the miscarriage sample into your doctor’s office immediately, store the sample in the refrigerator to preserve the tissue. Please DO NOT freeze the sample. It is important to remember, there is nothing you can do to prevent a miscarriage, and you did not cause this miscarriage to happen. Chromosome testing after a miscarriage may provide you with more information about the cause of your loss. Please discuss this option with your physician. For more information or to If you wish to speak with a Natera genetic You can also visit our website receive an Anora collection kit counselor about Anora, you can schedule http://www.natera.com/ contact Natera at a free phone genetic information session anora-miscarriage-test 650-249-9090 by calling 650-249-9090 or online at to view an informative video www.naterasession.com or read the common FAQs NAT-9000029.

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Case-Scenario-10-FINAL.Pdf
Case scenario 10 – Magdalena Part 1 • Magdalena is 26 years old. She is 13 weeks pregnant and had a high chance combined test result of 1 in 140 for trisomy 13 with an NT measurement of 2.4mm. • After a lengthy discussion about her options, she decided to have NIPT. • The results reported a greater than 60% chance of the baby having Patau’s syndrome. She decided to have an invasive test. A CVS was performed. Would you have offered a CVS to this patient? a) No - she should be offered an amniocentesis only, due to the chance of placental factors affecting a result. b) Yes - the patient should be informed of risks and benefits of both CVS and amniocentesis. Answer b) Yes - the patient should be informed of the risks and benefits of a CVS and amniocentesis. Additional note A patient/couple should be informed of the options of both forms of diagnostic procedures. They should be informed of the benefits and limitations of each test, this should include timing of testing, possible results and risks of miscarriage. This discussion should also include the couples ethical, religious, social and individual beliefs. Name the type of mosaicism that can cause a false-positive result with NIPT. a) Feto-placental mosaicism b) Placental mosaicism c) Fetal mosaicism Answer b) Placental mosaicism Additional note There is a discrepancy of the cell line in the placenta and baby. The abnormal cell lines are seen in the placenta and not on the fetus. There is a small chance that a 'high chance report is caused by 'placental mosaicism', therefore a CVS may also report 'mosaicism’.
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