1 Cigarette smoke induces overexpression of active human cathepsin S in lungs 2 from current smokers with or without COPD 3 4 1,2,#,* 3* 1,2 5 Pierre-Marie Andrault , Andrea C. Schamberger , Thibault Chazeirat , Damien 1,4 1, † 3 3 6 Sizaret , Justine Renault , Claudia A. Staab-Weijnitz , Elisabeth Hennen , Agnès Petit- 7 Courty1,2, Mylène Wartenberg1,2, Ahlame Saidi1,2, Thomas Baranek1,2, Serge Guyetant1,4, 1,2 3, ‡ 1,2 1,2¶ 8 Yves Courty , Oliver Eickelberg , Gilles Lalmanach , Fabien Lecaille 9 10 1 Université de Tours, Tours, France 11 2 INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires, Team Mécanismes 12 Protéolytiques dans l'Inflammation, Tours, France. 13 3 Comprehensive Pneumology Center, Institute of Lung Biology and Disease, University 14 Hospital, Ludwig-Maximilians-University and Helmholtz Zentrum München, Member of the 15 German Center for Lung Research (DZL), Munich, Germany. 16 4 Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service d'Anatomie et 17 Cytologie Pathologique, Tours, France. 18 19 # Current address: Department of Oral Biological and Medical Sciences, Faculty of Dentistry, 20 University of British Columbia, Vancouver, Canada. 21 † Current address: Unité de Biologie Fonctionnelle et Adaptative, CNRS, UMR 8251, 22 Université Paris Diderot, Paris 7, France 23 ‡ Current address: Division of Pulmonary and Critical Care Medicine, University of Colorado 24 Anschutz School of Medicine, Aurora, USA. 25 26 ¶Corresponding author information : Fabien Lecaille, PhD, Université de Tours, INSERM, 27 UMR 1100, CEPR, 10 Boulevard Tonnellé, F-37032 Tours cedex, France. Tel: (+33) 28 247366047; e-mail:
[email protected] 29 30 *These authors contributed equally to this manuscript.