Fatty Acids and Related Masses
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Meta Gene 2 (2014) 746–760
Meta Gene 2 (2014) 746–760 Contents lists available at ScienceDirect Meta Gene Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat Daniel Estanislao Goszczynski a,c, Juliana Papaleo Mazzucco b, María Verónica Ripoli a, Edgardo Leopoldo Villarreal b, Andrés Rogberg-Muñoz a, Carlos Alberto Mezzadra b, Lilia Magdalena Melucci b,⁎, Guillermo Giovambattista a,⁎⁎ a IGEVET, CCT LA PLATA CONICET, FCV, UNLP, La Plata B1900AVW, CC 296, Argentina b Unidad Integrada INTA Balcarce — FCA, UNMdP, Argentina c Fellow of the Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Argentina article info abstract Article history: LIPE is an intracellular neutral lipase, which is capable of hydrolyzing a va- Received 10 June 2014 riety of esters and plays a key role in the mobilization of fatty acids from Revised 26 August 2014 diacylglycerols. The objectives of this study were to characterize the Accepted 3 September 2014 genetic polymorphism of bovine LIPE gene and to evaluate the possible Available online 16 October 2014 association between three SNPs in the coding regions of this gene with the fatty acid composition of meat in a cattle population. Forty-three unre- Keywords: lated animals from different cattle breeds were re-sequenced and 21 SNPs LIPE fi Polymorphism were detected over approximately 2600 bp, ve of these SNPs were novel. Bovine Three SNPs were selected, on the basis of evolutionary conservation, to Lipid content perform validation and association studies in a crossbred cattle popula- tion. Our results may suggest a possible association of SNP1 with contents of oleic acid and total monounsaturated fatty acids (p b 0.01), and SNP2 and SNP3 with Heneicosylic acid content (p b 0.01), may be helpful to improve the quality of meat and improve health. -
(12) United States Patent (10) Patent No.: US 9,375.433 B2 Dilly Et Al
US009375433B2 (12) United States Patent (10) Patent No.: US 9,375.433 B2 Dilly et al. (45) Date of Patent: *Jun. 28, 2016 (54) MODULATORS OF ANDROGENSYNTHESIS (52) U.S. Cl. CPC ............. A6 IK3I/519 (2013.01); A61 K3I/201 (71) Applicant: Tangent Reprofiling Limited, London (2013.01); A61 K3I/202 (2013.01); A61 K (GB) 31/454 (2013.01); A61K 45/06 (2013.01) (72) Inventors: Suzanne Dilly, Oxfordshire (GB); (58) Field of Classification Search Gregory Stoloff, London (GB); Paul USPC .................................. 514/258,378,379, 560 Taylor, London (GB) See application file for complete search history. (73) Assignee: Tangent Reprofiling Limited, London (56) References Cited (GB) U.S. PATENT DOCUMENTS (*) Notice: Subject to any disclaimer, the term of this 5,364,866 A * 1 1/1994 Strupczewski.......... CO7C 45/45 patent is extended or adjusted under 35 514,254.04 U.S.C. 154(b) by 0 days. 5,494.908 A * 2/1996 O’Malley ............. CO7D 261/20 514,228.2 This patent is Subject to a terminal dis 5,776,963 A * 7/1998 Strupczewski.......... CO7C 45/45 claimer. 514,217 6,977.271 B1* 12/2005 Ip ........................... A61K 31, 20 (21) Appl. No.: 14/708,052 514,560 OTHER PUBLICATIONS (22) Filed: May 8, 2015 Calabresi and Chabner (Goodman & Gilman's The Pharmacological (65) Prior Publication Data Basis of Therapeutics, 10th ed., 2001).* US 2015/O238491 A1 Aug. 27, 2015 (Cecil's Textbook of Medicine pp. 1060-1074 published 2000).* Stedman's Medical Dictionary (21st Edition, Published 2000).* Okamoto et al (Journal of Pain and Symptom Management vol. -
WO 2017/074902 Al 4 May 20 17 (04.05.2017) W P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/074902 Al 4 May 20 17 (04.05.2017) W P O P C T (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 8/37 (2006.01) A61Q 19/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 31/215 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (21) International Application Number: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/US2016/058591 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 25 October 2016 (25.10.201 6) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (25) Filing Language: English ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/247,803 29 October 20 15 (29. 10.20 15) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: GLAXOSMITHKLINE CONSUMER TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, HEALTHCARE HOLDINGS (US) LLC [US/US]; 271 1 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Centerville Road, Suite 400, Wilmington, DE 19808 (US). -
Modeling the Effect of Heat Treatment on Fatty Acid Composition in Home-Made Olive Oil Preparations
Open Life Sciences 2020; 15: 606–618 Research Article Dani Dordevic, Ivan Kushkevych*, Simona Jancikova, Sanja Cavar Zeljkovic, Michal Zdarsky, Lucia Hodulova Modeling the effect of heat treatment on fatty acid composition in home-made olive oil preparations https://doi.org/10.1515/biol-2020-0064 refined olive oil in PUFAs, though a heating temperature received May 09, 2020; accepted May 25, 2020 of 220°C resulted in similar decrease in MUFAs and fi Abstract: The aim of this study was to simulate olive oil PUFAs, in both extra virgin and re ned olive oil samples. ff fi use and to monitor changes in the profile of fatty acids in The study showed di erences in fatty acid pro les that home-made preparations using olive oil, which involve can occur during the culinary heating of olive oil. repeated heat treatment cycles. The material used in the Furthermore, the study indicated that culinary heating experiment consisted of extra virgin and refined olive oil of extra virgin olive oil produced results similar to those fi samples. Fatty acid profiles of olive oil samples were of the re ned olive oil heating at a lower temperature monitored after each heating cycle (10 min). The out- below 180°C. comes showed that cycles of heat treatment cause Keywords: virgin olive oil, refined olive oil, saturated significant (p < 0.05) differences in the fatty acid profile fatty acids, monounsaturated fatty acids, polyunsatu- of olive oil. A similar trend of differences (p < 0.05) was rated fatty acids, cross-correlation analysis found between fatty acid profiles in extra virgin and refined olive oils. -
Improvement of Lipid Production from an Oil-Producing Filamentous Fungus, Penicillium Brevicompactum NRC 829, Through Central Composite Statistical Design
Ann Microbiol (2017) 67:601–613 DOI 10.1007/s13213-017-1287-x ORIGINAL ARTICLE Improvement of lipid production from an oil-producing filamentous fungus, Penicillium brevicompactum NRC 829, through central composite statistical design Thanaa H. Ali1 & Mamdouh S. El-Gamal2 & Dina H. El-Ghonemy1 & Ghada E. Awad3 & Amir E. Tantawy1 Received: 12 March 2017 /Accepted: 13 July 2017 /Published online: 7 August 2017 # Springer-Verlag GmbH Germany and the University of Milan 2017 Abstract In the present study, 13 filamentous fungi were commercial development for the production of LA by fer- screened for their lipid production and an oleaginous fun- mentation using cheap raw material. gus, Penicillium brevicompactum NRC 829, was found to be the highest lipid producer. Screening of various agro- Keywords Linoleic acid . Penicillium brevicompactum NRC industrial residues was performed and sunflower oil cake 829 . Response surface methodology . Unsaturated fatty acids proved to be the best substrate for lipid production. A central composite design was employed to investigate the optimum concentrations of the most significant medi- Introduction um components required to improve the lipid production by P. brevicompactum. The results clearly revealed that Polyunsaturated fatty acids (PUFAs) are long-chain fatty − the maximal lipid production of 8.014 ± 0.06 gL 1 acids containing two or more double bonds in their acyl (representing 57.6% lipid/dry biomass) was achieved by chains. Biosynthesis of PUFAs involves both methyl- the fungus when grown for 6 days at 30 °C under static directed and carboxyl-directed desaturases. The primary condition in a medium containing sunflower oil cake, product of fatty acid biosynthesis in oilseed crops is the NaNO3 and KCl at final concentrations of 8, 0.75 and 18-carbon monounsaturated oleic acid (C18:1–9). -
United States Patent (19) 11 Patent Number: 5,034,441 Nakano Et Al
United States Patent (19) 11 Patent Number: 5,034,441 Nakano et al. 45 Date of Patent: Jul. 23, 1991 54 STYRENE-BASED RESIN COMPOSITION (56. References Cited AND PROCESS FOR PRODUCING U.S. PATENT DOCUMENTS MOLDING PRODUCTS THEREOF 4,463,113 7/1984 Nakahara et al. ................... 524/117 4,619,959 10/1986 Matsubara et al. .. ... 524/228 75) Inventors: Akikazu Nakano; Takashi Sumitomo, 4,680,353 7/1987 Ishihara et al. .. ... 526/59 both of Ichihara, Japan 4,820,772 4/1989 Goto et al. .......................... 524/117 73 Assignee: Idemitsu Kosan Co., Ltd., Tokyo, Primary Examiner-Joseph L. Schofer Japan Assistant Examiner-Mark D. Sweet Attorney, Agent, or Firm-Frishauf, Holtz, Goodman & (21) Appl. No.: 559,971 Woodward 57 ABSTRACT (22 Filed: Jul. 27, 1990 Disclosed is a styrene-based resin composition which comprises (a) 100 parts by weight of styrene-based poly Related U.S. Application Data mer having a high degree of syndiotactic configuration, 63 Continuation-in-part of Ser. No. 470,975, Jan. 26, 1990, (b) 0.01 to 15 parts by weight of at least one nucleating abandoned. agent selected from an organophosphorus compound and a metal salt of an organic acid, and (c) 0.01 to 15 (30) Foreign Application Priority Data parts by weight of at least one component selected from a polyoxyalkylene compound, a fatty acid and a deriva Feb. 2, 1989 (JP) Japan .................................... 1-22587 tive thereof. 51 Int. Cli................................................ C08K 5/15 The composition can produce various molding prod 52 U.S. C. .................................... 524/117; 524/127; ucts with excellent mold-releasing property, surface 524/377; 524/385; 524/388; 524/307; 524/228; gloss, bending strength, bending modulus and heat resis 524/577; 524/394 tance. -
Component, Fatty Acid and Mineral Composition of Rice Bran Oil Extracted by Multistage with Hexane and Ethanol
INTERNATIONAL JOURNAL OF SCIENTIFIC & TECHNOLOGY RESEARCH VOLUME 6, ISSUE 11, NOVEMBER 2017 ISSN 2277-8616 Component, Fatty Acid And Mineral Composition Of Rice Bran Oil Extracted By Multistage With Hexane And Ethanol Fajriyati Mas’ud, Meta Mahendradatta, Amran Laga, Zainal Zainal Abstract: Rice bran oil (RBO) has been extracted from Celebes rice bran by multistage extraction with hexane solvent followed by ethanol to see the component, profile of fatty acids and mineral contained in both of them. As a comparison, RBO directly extracted with ethanol was also presented. Extraction process was performed using reflux method at 55oC, for 5 hours with bran and solvent ratio of 1:7. Analysis of components and fatty acids of RBO was conducted with GC-MS QP 2010 Shimadzu. Oleic, linoleic and palmitic were found dominant in first stage extraction by hexane with concentration of 3716.56, 1630.78 and 1021.89 mg/L, respectively. Palmitic (6.34 mg/L), lauric (4.78 mg/L), and linoleic (3.52 mg/L) were dominant in the second stage extraction by ethanol. Linoleic (28.85 mg/L), stearic (2.88 mg/L) and myristic (2.02 mg/L) were found in extracted directly by ethanol. RBO extracted with hexane had 18.6% of saturated fatty acid and 81.4% of unsaturated fatty acids, with ratio of saturated fatty acids : monounsaturated fatty acids: polyunsaturated fatty acids of approximately 1: 2.3 : 1.3. It contained about 56.7% of monounsaturated, 24.7% of polyunsaturated, and 18.6% of saturated fatty acids. In the present paper, we provide also an analysis of mineral composition of RBO by X-ray Spectrometer and melting point of RBO by Differential Scanning Calorimeter (DSC) instrument. -
Biochemistry Prologue to Lipids
Paper : 05 Metabolism of Lipids Module: 01 Prologue to Lipids Principal Investigator Dr. Sunil Kumar Khare, Professor, Department of Chemistry, IIT-Delhi Paper Coordinator and Dr. Suaib Luqman, Scientist (CSIR-CIMAP) Content Writer & Assistant Professor (AcSIR) CSIRDr. Vijaya-CIMAP, Khader Lucknow Dr. MC Varadaraj Content Reviewer Prof. Prashant Mishra, Professor, Department of Biochemical Engineering and Biotechnology, IIT-Delhi 1 METABOLISM OF LIPIDS Biochemistry Prologue to Lipids DESCRIPTION OF MODULE Subject Name Biochemistry Paper Name 05 Metabolism of Lipids Module Name/Title 01 Prologue to Lipids 2 METABOLISM OF LIPIDS Biochemistry Prologue to Lipids 1. Objectives To understand what is lipid Why they are important How they occur in nature 2. Concept Map LIPIDS Fatty Acids Glycerol 3. Description 3.1 Prologue to Lipids In 1943, the term lipid was first used by BLOOR, a German biochemist. Lipids are heterogeneous group of compounds present in plants and animal tissues related either actually or potentially to the fatty acids. They are amphipathic molecules, hydrophobic in nature originated utterly or in part by thioesters (carbanion-based condensations of fatty acids and/or polyketides etc) or by isoprene units (carbocation-based condensations of prenols, sterols, etc). Lipids have the universal property of being: i. Quite insoluble in water (polar solvent) ii. Soluble in benzene, chloroform, ether (non-polar solvent) 3 METABOLISM OF LIPIDS Biochemistry Prologue to Lipids Thus, lipids include oils, fats, waxes, steroids, vitamins (A, D, E and K) and related compounds, such as phospholipids, triglycerides, diglycerides, monoglycerides and others, which are allied more by their physical properties than by their chemical assests. -
Graham Centre Monograph No. 4
Long-chain omega-3 polyunsaturated fatty acids in ruminant nutrition: benefits to animals and humans Edward H. Clayton Livestock Research Officer – Ruminant Nutrition NSW Department of Primary Industries, Wagga Wagga Agricultural Institute Pine Gully Rd, Wagga Wagga NSW 2650 Graham Centre Monograph No. 4 Edited by: Toni Nugent and Catriona Nicholls August 2014 © State of New South Wales through Department of Trade and Investment, Regional Infrastructure and Services 2014 This publication is copyright. You may download, display, print and reproduce this material in an unaltered form only (retaining this notice) for your personal use or for non-commercial use within your organisation. To copy, adapt, publish, distribute or commercialise any of this publication you will need to seek permission from the NSW Department of Primary Industries. Disclaimer: The information contained in this publication is based on knowledge and understanding at the time of writing (August 2014). However, because of advances in knowledge, users are reminded of the need to ensure that information upon which they rely is up to date and to check currency of the information with the appropriate officer of the NSW Department of Primary Industries or the user’s independent advisor. All sources of information in the current publication are acknowledged in the text. No further reproduction should be made without first obtaining prior written approval of the copyright owner. For updates to this publication, check www.grahamcentre.net/ Published by the NSW Department of Primary Industries. First published August 2014 ISBN 978 1 74256 678 8 Cover design by: Sharon Kiss Cover photo by: Toni Nugent, Graham Centre for Agricultural Innovation Author’s Contact: Dr Edward Clayton, Livestock Research Officer, NSW Department of Primary Industries, Wagga Wagga Agricultural Institute, Pine Gully Rd, Wagga Wagga NSW 2650 Email: [email protected] Citation: Clayton EH (2014). -
Normal-Phase HPLC-ELSD to Compare Lipid Profiles of Different
foods Article Normal-Phase HPLC-ELSD to Compare Lipid Profiles of Different Wheat Flours Sara Melis 1,* , Imogen Foubert 2 and Jan A. Delcour 1 1 Laboratory of Food Chemistry and Biochemistry (LFCB) and Leuven Food Science and Nutrition Research Centre (LFoRCe), KU Leuven, Kasteelpark Arenberg 20 Box 2486, B-3001 Leuven, Belgium; [email protected] 2 Research Unit of Food & Lipids and Leuven Food Science and Nutrition Research Centre (LFoRCe), KU Leuven Kulak, Etienne Sabbelaan 53, B-8500 Kortrijk, Belgium; [email protected] * Correspondence: [email protected]; Tel.: +32-1637-6433 Abstract: Normal-phase high-performance liquid chromatography (HPLC) is widely used in com- bination with evaporative light scattering detection (ELSD) for separating and detecting lipids in various food samples. ELSD responses of different lipids were evaluated to elucidate the possibilities and challenges associated with quantification by means of HPLC-ELSD. Not only the number and type of polar functional groups but also the chain length and degree of unsaturation of (free or esterified) fatty acids (FAs) had a significant effect on ELSD responses. Tripalmitin and trilinolein yielded notably different ELSD responses, even if their constituting free FAs produced identical responses. How FA structure impacts ELSD responses of free FAs is thus not predictive for those of triacylglycerols and presumably other lipids containing esterified FAs. Because ELSD responses of lipids depend on the identity of the (esterified) FA(s) which they contain, fully accurate lipid quantification with HPLC-ELSD is challenging and time-consuming. Nonetheless, HPLC-ELSD is a good and fast technique to semi-quantitatively compare the levels of different lipid classes Citation: Melis, S.; Foubert, I.; between samples of comparable FA composition. -
Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production
International Journal of Molecular Sciences Article Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production Eugene A. Osae 1,* , Tiffany Bullock 2, Madhavi Chintapalati 2, Susanne Brodesser 3 , Samuel Hanlon 1, Rachel Redfern 1, Philipp Steven 4 , C. Wayne Smith 2, Rolando E. Rumbaut 2,5 and Alan R. Burns 1 1 College of Optometry, University of Houston, Houston, TX 77204, USA; [email protected] (S.H.); [email protected] (R.R.); [email protected] (A.R.B.) 2 Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA; [email protected] (T.B.); [email protected] (M.C.); [email protected] (C.W.S.); [email protected] (R.E.R.) 3 CECAD Research Center, Lipidomics/Metabolomics Facility, University of Cologne, 50931 Cologne, Germany; [email protected] 4 Department of Ophthalmology, Division for Dry-Eye and Ocular GvHD, Medical Faculty, University of Cologne, 50937 Cologne, Germany; [email protected] 5 Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA * Correspondence: [email protected]; Tel.: +1-346-317-6273 Received: 14 October 2020; Accepted: 16 November 2020; Published: 20 November 2020 Abstract: Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity where mice develop dyslipidemia. Methods: Male C57/BL6 mice (8/group, age = 6 wks) were fed a normal (ND; 15% kcal fat) or an obesogenic high-fat diet (HFD; 42% kcal fat) for 10 wks. -
Presentación De Powerpoint
Suspect and Non-Target Analysis of polar organic compounds in biota using LC-HRMS Pablo Gago-Ferrero Contact: [email protected] Introduction Emerging Pollutants (EPs) Pharmaceuticals Personal care products Flame retardants Food additives Disinfection by-products Pesticides + Metabolites & Transformation Products (TPs) aquatic environment & Biota 2 Introduction Challenges in the analysis of organic contaminants in biota Sample preparation (lipid content, trace level, sample size) Thousands of organic contaminants with very different physicochemical properties Investigation of new (unknown) contaminants potentially dangerous for the ecosystems (and human health) Metabolites 3 Target screening Target screening • Known EP Well-established analytical (quantitative) • Reference standards methods for many priority contaminants available Good limits of detection • Unequivocal identification High accuracy Reliable quantification 4 Why Suspect / non-target? Target screening is biased due to preselection of substances Most organic constitutes of environmental samples are not identified! Potential chemical stressors may be omitted Most of the labs analyse the same substances Reference standards are necessary for all compounds 5 Suspect & non-target: Where to put our efforts? Thousands of chromatographic peaks in one sample Impossible & Pointless to identify all of them Smart use Suspect & Non target strategies Define Research question &Prioritization Suspect screening Classical micropollutants for which their presence in biota has