Purification and Some Properties of Cyclohexylamine Oxidase
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Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines
This is a repository copy of Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/133028/ Version: Accepted Version Article: Cosgrove, SC, Hussain, S, Turner, NJ et al. (1 more author) (2018) Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines. ACS Catalysis, 8 (6). pp. 5570-5573. ISSN 2155-5435 https://doi.org/10.1021/acscatal.8b01220 (c) 2018, American Chemical Society. This is an author produced version of a paper published in ACS Catalysis. Uploaded in accordance with the publisher's self-archiving policy. Reuse Items deposited in White Rose Research Online are protected by copyright, with all rights reserved unless indicated otherwise. They may be downloaded and/or printed for private study, or other acts as permitted by national copyright laws. The publisher or other rights holders may allow further reproduction and re-use of the full text version. This is indicated by the licence information on the White Rose Research Online record for the item. Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing [email protected] including the URL of the record and the reason for the withdrawal request. [email protected] https://eprints.whiterose.ac.uk/ Synergistic chemo/biocatalytic synthesis of alkaloidal tetrahydroquinolines Sebastian C. Cosgrove,1,2 Shahed Hussain,1 Nicholas J. Turner*1 and Stephen P. Marsden*2 1School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manches- ter M1 7DN, United Kingdom 2Institute of Process Research and Development and School of Chemistry, University of Leeds, Leeds, LS2 9JT, United Kingdom ABSTRACT: The power of complementary chemo- and biocatalytic transformations is demonstrated in the asymmetric syn- thesis of 2-substituted tetrahydroquinolines. -
Development of Swiss Biotechnology Beyond the Biopharmaceutical Sector in Memoriam Prof
BUILDING BRIDGES BETWEEN BIOTECHNOLOGY AND CHEMISTRY – IN MEMORIAM ORESTE GHISALBA CHIMIA 2020, 74, No. 5 345 doi:10.2533/chimia.2020.345 Chimia 74 (2020) 345–359 © H.P. Meyer and O. Werbitzky Development of Swiss Biotechnology Beyond the Biopharmaceutical Sector In memoriam Prof. Dr. Oreste Ghisalba (1946–2018) Hans-Peter Meyera* and Oleg Werbitzkyb Abstract: Although diverse, the potential business opportunities for biotechnology outside the biopharmaceutical market are very large. White biotechnology can offer sustainable operations and products, while investments tend to be lower than those in red biotechnology. But a number of bottlenecks and roadblocks in Switzerland must be removed to realise the full potential of white biotechnology. This was also the point of view of Oreste Ghisalba, who wanted to be part of a new initiative to facilitate the creation of additional business, new pro- cesses and new products. This initiative requires the identification and the use of synergies and a much better cooperation between academia and industry through targeted networking. Unfortunately, we must carry on with this task without Oreste, whom we will miss for his deep knowledge and friendship. Keywords: Bio-based · Fine chemicals · Industrial biotechnology · Swiss economy · White biotechnology Hans-Peter Meyer holds a PhD in micro- venture partners and Managing Director of NC Health Sciences biology from the University of Fribourg since 2015. (Switzerland). He spent three years post- graduate and postdoc studies at the STFI 1. A Short History of the Swiss Biotechnology Industry in Stockholm (Sweden), the University The Swiss pharmaceutical and chemical industries have been of Pennsylvania and Lehigh University in responsible for almost half of the country’s exports for many years the USA. -
Chemical Resistance List
Chemical Resistance List Resistance Substance Permeation Time/Level to Degradation Fluoro- natural chloro- nitrile/ nitrile carbon butyl latex prene chloroprene rubber NR CR CR NBR FKM IIR NR NR CR CR NBR NBR NBR NBR NBR FKM IIR IIR NBR NBR 395 450, 451 720, 722 717 727 730, 732 740, 741 743 754 764 890 897 898 chemical physical 403 706 723, 725 733, 836 742, 757 state 708 726 736 - 739 759 - 0 - 0 0 + 1-methoxy-2-propanol paste 4 2 2 3 4 4 B 1 3 4 6 6 - 0 - 0 0 + 1-methoxy-2-propyl acetate liquid 3 1 1 3 3 A B 2 3 6 6 - 0 0 - 0 + 1-methyl-2-pyrrolidone liquid 5 2 3 3 3 2 A B 1 3 3 6 6 - 0 + + + - 1,1,2-trichlorotrifluoroethane liquid 1 0 5 4 6 6 1 1 2 1 6 1 2 - - - - - - 1.2-epoxy ethane (ethylene oxide) liquid B A A A A 0 0 0 B 1 2 - - - - - - 1.2-epoxy propane (propylene oxide) liquid B A A A 1 A 0 0 0 B 1 2 + + + + + + 1.2-propanediol liquid 6 6 6 6 6 6 6 6 6 6 6 6 6 - + - + + 0 2-ethyl hexyl acrylate liquid 2 1 1 5 6 1 1 2 6 2 3 - 0 0 0 + + 2-mercaptoethanol liquid 3 2 4 4 4 4 1 1 3 6 6 6 - - - 0 0 - 2-methoxy-2-methyl propane liquid 1 B B 2 4 A 1 4 1 3 2 2 - - - - - 0 3-hexanone liquid 1 B 1 1 1 0 0 0 0 0 3 3 - - - - - 0 4-heptanone liquid 1 A 1 1 1 A 0 0 0 B 3 3 - - - - - + acetaldehyde liquid 1 1 1 1 B 0 0 0 A 0 6 6 0 0 0 - - + acetic acid anhydride liquid 6 3 3 3 3 2 A B 1 B 2 6 6 + + + + + + acetic acid, 10 % liquid 6 6 6 6 6 6 6 6 6 6 6 6 6 0 + + + + + acetic acid, 50 % liquid 5 4 6 6 6 2 4 6 6 6 6 - - - - 0 + acetic acid, conc. -
Synthetic Turf Scientific Advisory Panel Meeting Materials
California Environmental Protection Agency Office of Environmental Health Hazard Assessment Synthetic Turf Study Synthetic Turf Scientific Advisory Panel Meeting May 31, 2019 MEETING MATERIALS THIS PAGE LEFT BLANK INTENTIONALLY Office of Environmental Health Hazard Assessment California Environmental Protection Agency Agenda Synthetic Turf Scientific Advisory Panel Meeting May 31, 2019, 9:30 a.m. – 4:00 p.m. 1001 I Street, CalEPA Headquarters Building, Sacramento Byron Sher Auditorium The agenda for this meeting is given below. The order of items on the agenda is provided for general reference only. The order in which items are taken up by the Panel is subject to change. 1. Welcome and Opening Remarks 2. Synthetic Turf and Playground Studies Overview 4. Synthetic Turf Field Exposure Model Exposure Equations Exposure Parameters 3. Non-Targeted Chemical Analysis Volatile Organics on Synthetic Turf Fields Non-Polar Organics Constituents in Crumb Rubber Polar Organic Constituents in Crumb Rubber 5. Public Comments: For members of the public attending in-person: Comments will be limited to three minutes per commenter. For members of the public attending via the internet: Comments may be sent via email to [email protected]. Email comments will be read aloud, up to three minutes each, by staff of OEHHA during the public comment period, as time allows. 6. Further Panel Discussion and Closing Remarks 7. Wrap Up and Adjournment Agenda Synthetic Turf Advisory Panel Meeting May 31, 2019 THIS PAGE LEFT BLANK INTENTIONALLY Office of Environmental Health Hazard Assessment California Environmental Protection Agency DRAFT for Discussion at May 2019 SAP Meeting. Table of Contents Synthetic Turf and Playground Studies Overview May 2019 Update ..... -
23.5 Basicity and Acidity of Amines
23_BRCLoudon_pgs5-0.qxd 12/8/08 1:22 PM Page 1122 1122 CHAPTER 23 • THE CHEMISTRY OF AMINES alkylamines, this resonance occurs at rather small chemical shift—typically around d 1. In aromatic amines, this resonance is at greater chemical shift, as in the second of the preceding examples. Like the OH protons of alcohols, phenols, and carboxylic acids, the NH protons of amines under most conditions undergo rapid exchange (Secs. 13.6 and 13.7D). For this reason, split- ting between the amine N H and adjacent C H groups is usually not observed. Thus, in the NMR spectrum of diethylamine,L the N H resonanceL is a singlet rather than the triplet ex- pected from splitting by the adjacent CHL2 protons. In some amine samples, the N H resonance is broadened and, like the OL H protonL of alcohols, it can be obliterated fromL the spectrum by exchange with D2O (the “DL2O shake,” p. 611). The characteristic 13C NMR absorptions of amines are those of the a-carbons—the carbons attached directly to the nitrogen. These absorptions occur in the d 30–50 chemical-shift range. As expected from the relative electronegativities of oxygen and nitrogen, these shifts are somewhat less than the a-carbon shifts of ethers. PROBLEMS 23.4 Identify the compound that has an M 1 ion at mÜz 136 in its CI mass spectrum, an IR 1 + = absorption at 3279 cm_ , and the following NMR spectrum: d 0.91 (1H, s), d 1.07 (3H, t, J 7Hz), d 2.60 (2H, q, J 7Hz), d 3.70 (2H, s), d 7.18 (5H, apparent s). -
Gasket Chemical Services Guide
Gasket Chemical Services Guide Revision: GSG-100 6490 Rev.(AA) • The information contained herein is general in nature and recommendations are valid only for Victaulic compounds. • Gasket compatibility is dependent upon a number of factors. Suitability for a particular application must be determined by a competent individual familiar with system-specific conditions. • Victaulic offers no warranties, expressed or implied, of a product in any application. Contact your Victaulic sales representative to ensure the best gasket is selected for a particular service. Failure to follow these instructions could cause system failure, resulting in serious personal injury and property damage. Rating Code Key 1 Most Applications 2 Limited Applications 3 Restricted Applications (Nitrile) (EPDM) Grade E (Silicone) GRADE L GRADE T GRADE A GRADE V GRADE O GRADE M (Neoprene) GRADE M2 --- Insufficient Data (White Nitrile) GRADE CHP-2 (Epichlorohydrin) (Fluoroelastomer) (Fluoroelastomer) (Halogenated Butyl) (Hydrogenated Nitrile) Chemical GRADE ST / H Abietic Acid --- --- --- --- --- --- --- --- --- --- Acetaldehyde 2 3 3 3 3 --- --- 2 --- 3 Acetamide 1 1 1 1 2 --- --- 2 --- 3 Acetanilide 1 3 3 3 1 --- --- 2 --- 3 Acetic Acid, 30% 1 2 2 2 1 --- 2 1 2 3 Acetic Acid, 5% 1 2 2 2 1 --- 2 1 1 3 Acetic Acid, Glacial 1 3 3 3 3 --- 3 2 3 3 Acetic Acid, Hot, High Pressure 3 3 3 3 3 --- 3 3 3 3 Acetic Anhydride 2 3 3 3 2 --- 3 3 --- 3 Acetoacetic Acid 1 3 3 3 1 --- --- 2 --- 3 Acetone 1 3 3 3 3 --- 3 3 3 3 Acetone Cyanohydrin 1 3 3 3 1 --- --- 2 --- 3 Acetonitrile 1 3 3 3 1 --- --- --- --- 3 Acetophenetidine 3 2 2 2 3 --- --- --- --- 1 Acetophenone 1 3 3 3 3 --- 3 3 --- 3 Acetotoluidide 3 2 2 2 3 --- --- --- --- 1 Acetyl Acetone 1 3 3 3 3 --- 3 3 --- 3 The data and recommendations presented are based upon the best information available resulting from a combination of Victaulic's field experience, laboratory testing and recommendations supplied by prime producers of basic copolymer materials. -
Safety Data Sheet
SAFETY DATA SHEET 1. Product and Company Identification Product identifier BOILERMATE 3300C Other means of identification Not available Recommended use Boiler Water Treatment Recommended restrictions None known. Manufacturer information Miura America Co., Ltd 2200 Steven B Smith Blvd Rockmart, GA 30153 USA Phone: 678-685-0929 Toll Free: 1-888-309-5574 Fax: 678-685-0930 Emergency Phone: 1-800-424-9300 (CHEMTREC) 2. Hazards Identification Physical hazards Flammable liquids Category 3 Health hazards Acute toxicity, oral Category 4 Acute toxicity, dermal Category 3 Skin corrosion/irritation Category 1 Serious eye damage/eye irritation Category 1 Reproductive toxicity Category 2 Environmental hazards Not classified. WHMIS 2015 defined hazards Not classified Label elements Signal word Danger Hazard statement Flammable liquid and vapor. Harmful if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. Suspected of damaging fertility. Precautionary statement Prevention Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Keep container tightly closed. Ground and bond container and receiving equipment. Use explosion-proof electrical, ventilating and lighting equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe mist or vapor. Do not eat, drink or smoke when using this product. Wash thoroughly after handling. Wear protective gloves, protective clothing, eye protection and face protection. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Response In case of fire: Use appropriate media to extinguish. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. -
Dissociation Constants of Organic Acids and Bases
DISSOCIATION CONSTANTS OF ORGANIC ACIDS AND BASES This table lists the dissociation (ionization) constants of over pKa + pKb = pKwater = 14.00 (at 25°C) 1070 organic acids, bases, and amphoteric compounds. All data apply to dilute aqueous solutions and are presented as values of Compounds are listed by molecular formula in Hill order. pKa, which is defined as the negative of the logarithm of the equi- librium constant K for the reaction a References HA H+ + A- 1. Perrin, D. D., Dissociation Constants of Organic Bases in Aqueous i.e., Solution, Butterworths, London, 1965; Supplement, 1972. 2. Serjeant, E. P., and Dempsey, B., Ionization Constants of Organic Acids + - Ka = [H ][A ]/[HA] in Aqueous Solution, Pergamon, Oxford, 1979. 3. Albert, A., “Ionization Constants of Heterocyclic Substances”, in where [H+], etc. represent the concentrations of the respective Katritzky, A. R., Ed., Physical Methods in Heterocyclic Chemistry, - species in mol/L. It follows that pKa = pH + log[HA] – log[A ], so Academic Press, New York, 1963. 4. Sober, H.A., Ed., CRC Handbook of Biochemistry, CRC Press, Boca that a solution with 50% dissociation has pH equal to the pKa of the acid. Raton, FL, 1968. 5. Perrin, D. D., Dempsey, B., and Serjeant, E. P., pK Prediction for Data for bases are presented as pK values for the conjugate acid, a a Organic Acids and Bases, Chapman and Hall, London, 1981. i.e., for the reaction 6. Albert, A., and Serjeant, E. P., The Determination of Ionization + + Constants, Third Edition, Chapman and Hall, London, 1984. BH H + B 7. Budavari, S., Ed., The Merck Index, Twelth Edition, Merck & Co., Whitehouse Station, NJ, 1996. -
United States Patent 0 ,
2,797,240 United States Patent 0 ,_ .. C€ Patented June 25, 1957 1 2 re?uxed. During the reaction .under re?ux conditions, a 2,797,240 voluminous precipitate initially torms, then two layers, METHOD OF PREPARING DICYCLOHEXYL and, ?nally, after 10 minutes a homogeneous solution CARBODIIIVIIDE forms. Gradually, as the heating progresses, the tem Gaston Arniard, Noisy-le-Sec, René Heymes, Romainville, perature of the reaction mixture, which, at the start, is and Leon Velluz, Paris, France, assignors to UCLAF, held down by the re?ux of the cyclohexylamine, rises Paris, France, a body corporate of France .and reaches 160° C. after two hours. At that moment a suddent solidi?cation be observed, whereupon the No Drawing. Application July 2, 1956, heating is discontinued, the solution is taken up with Serial No. 595,101 10 aqueous hydrochloric acid solution, is ?ltered, and the re Claims priority, application France September 15, 1955 sultant dicyclohexylurea is washed with water, alcohol and ether. Having been dried, it is recrystallized in 100 0111.3 5 Claims. (Cl. 260-551) .of absolute alcohol, ?nally producing 54 grams of dicyclo hexylurea in the form of colorless needles having a M. P. This invention relates to a method of preparing a car 15 of 234-235" C. bodiimide. More particularly this invention relates to a 33.6 grams of the dicyclohexylurea prepared in the method of making dicyclohexylcarbodiimide from dicyclo ‘above manner, 50 cm.3 of pyridine and 28.5 grams of p hexyl urea which makes it possible to recover a consider toluene sulfochloride are mixed together, stirred and heat able portion of the condensation material used in the ed for an hour and a half to 70-75 ‘’ C. -
Some Physical Properties of the Ternary System; Cyclohexylamine - Cyclohexanol - Cyclohexane
Fort Hays State University FHSU Scholars Repository Master's Theses Graduate School Summer 1953 Some Physical Properties of The Ternary System; Cyclohexylamine - Cyclohexanol - Cyclohexane. Arlin E. Mills Fort Hays Kansas State College Follow this and additional works at: https://scholars.fhsu.edu/theses Part of the Chemistry Commons Recommended Citation Mills, Arlin E., "Some Physical Properties of The Ternary System; Cyclohexylamine - Cyclohexanol - Cyclohexane." (1953). Master's Theses. 515. https://scholars.fhsu.edu/theses/515 This Thesis is brought to you for free and open access by the Graduate School at FHSU Scholars Repository. It has been accepted for inclusion in Master's Theses by an authorized administrator of FHSU Scholars Repository. SOME PHYSIC.AL PROPERTIES OF THE TERNARY SYSTEM: CYCLOHEXYLAMINE--CYCLOHEXANOL--CYCLOHEXANE being A thesis presented to the Graduate Faculty of the Fort Hays Kansas State College in partial fulfillment of the requirements for the Degree of Master of Science by Arlin E. Mills, A. B. Fort Hays Kansas State College Date i ACKNOWLEDGMENTS The author wishes to acknowledge his indebtedness to Dr. Harold S. Choguill, who suggested the problem and under whose direction this thesis was prepared, for his invaluable suggestions and constructive criticism. Acknowledgment is made to Dr. F. B. Streeter for his advice in preparing the bibliography and thesis structure. Acknowledgment also is made to Mr. David T. Sorensen for helpful suggestions and to the Visual Education Department of Fort Heys Kansas State College for their photographic assistance. ii TABLE OF CONTENTS PAGE INTRODUCTION • • • • • • • • • . • • . 1 The Theory of Liquids and Solutions 2 METHOD OF INVESTIGATION 8 EXPERIMENTAL • • • 10 Materials Used • • 10 Preparation of Samples . -
Acetaldehyde 16.05.2020.Pdf
Acetaldehyde Acetaldehyde (systematic name ethanal) is an organic chemical compound with the formula CH3CHO, sometimes abbreviated by chemists as MeCHO (Me = methyl). It is one of the most important aldehydes, occurring widely in nature and being produced on a large scale in industry. Acetaldehyde occurs naturally in coffee, bread, and ripe fruit, and is produced by plants. It is also produced by the partial oxidation of ethanol by the liver enzyme alcohol dehydrogenase and is a contributing cause of hangover after alcohol consumption. Pathways of exposure include air, water, land, or groundwater, as well as drink and smoke. Consumption of disulfiram inhibits acetaldehyde dehydrogenase, the enzyme responsible for the metabolism of acetaldehyde, thereby causing it to build up in the body. An aldehyde used as a starting material in the synthesis of 1-butanol (n-butyl alcohol), ethyl acetate, perfumes, flavourings, aniline dyes, plastics, synthetic rubber, and other chemical compounds. It has been manufactured by the hydration of acetylene and by the oxidation of ethanol (ethyl alcohol). Formula: C2H4O IUPAC ID: ethanal Boiling point: 20.2 °C Molar mass: 44.05 g/mol Density: 788 kg/m³ Melting point: -123.5 °C Preparation:- The main method of production is the oxidation of ethylene by the Wacker process, which involves oxidation of ethylene using a homogeneous palladium/copper system: 2 CH2=CH2 + O2 → 2 CH3CHO Smaller quantities can be prepared by the partial oxidation of ethanol in an exothermic reaction. This process typically is conducted over a silver catalyst at about 500–650 °C. 1 CH3CH2OH + ⁄2 O2 → CH3CHO + H2O This method is one of the oldest routes for the industrial preparation of acetaldehyde. -
Interagency Committee on Chemical Management
DECEMBER 14, 2018 INTERAGENCY COMMITTEE ON CHEMICAL MANAGEMENT EXECUTIVE ORDER NO. 13-17 REPORT TO THE GOVERNOR WALKE, PETER Table of Contents Executive Summary ...................................................................................................................... 2 I. Introduction .......................................................................................................................... 3 II. Recommended Statutory Amendments or Regulatory Changes to Existing Recordkeeping and Reporting Requirements that are Required to Facilitate Assessment of Risks to Human Health and the Environment Posed by Chemical Use in the State ............................................................................................................................ 5 III. Summary of Chemical Use in the State Based on Reported Chemical Inventories....... 8 IV. Summary of Identified Risks to Human Health and the Environment from Reported Chemical Inventories ........................................................................................................... 9 V. Summary of any change under Federal Statute or Rule affecting the Regulation of Chemicals in the State ....................................................................................................... 12 VI. Recommended Legislative or Regulatory Action to Reduce Risks to Human Health and the Environment from Regulated and Unregulated Chemicals of Emerging Concern ..............................................................................................................................