Chemical Properties Biological Description Solubility Information

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Chemical Properties Biological Description Solubility Information

Data Sheet (Cat.No.TN2100) Pratensein Chemical Properties CAS No.: 2284-31-3 Formula： C16H12O6 Molecular Weight： 300.3 Appearance： N/A Storage： 0-4℃ for short term (days to weeks), or -20℃ for long term (months). Biological Description Description Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells. Targets(IC50) AChR: None NF-κB: None Beta Amyloid: None In vitro Protective effect of five isoflavones (formononetin, daidzein, Pratensein, calycosin and irilone) from Trifolium pratense on lipopolysaccharide-induced dopaminergic neurodegeneration was studied for the first time. The results showed that all five isoflavones attenuated LPS-induced decrease in dopamine uptake and the number of dopaminergic neurons in a dose-dependent manner in rat mesencephalic neuron-glia cultures. Moreover, they also significantly inhibited LPS-induced activation of microglia and production of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. In addition, the rank order of protective potency of five isoflavones was: Pratensein>daidzein>calycosin>formononetin>irilone. Solubility Information Solubility < 1 mg/ml refers to the product slightly soluble or insoluble Preparing Stock Solutions 1mg 5mg 10mg 1 mM 3.330 mL 16.650 mL 33.300 mL 5 mM 0.666 mL 3.330 mL 6.660 mL 10 mM 0.333 mL 1.665 mL 3.330 mL 50 mM 0.067 mL 0.333 mL 0.666 mL Please select the appropriate solvent to prepare the stock solution, according to the solubility of the product in different solvents. The storage conditions and period of the stock solution: - 80 ℃ for 6 months; - 20 ℃ for 1 month. Please use it as soon as possible. Reference 1. Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons.Neurosci Res. 2008 Oct;62(2):123-30. Page 1 of 2 www.targetmol.com A DRUG SCREENING EXPERT Inhibitors · Natural Compounds · Compound Libraries This product is for Research Use Only · Not for Human or Veterinary or Therapeutic Use. Tel:781-999-4286 E-mail:[email protected] Address:36 Washington Street,Wellesley Hills,MA 02481 Page 2 of 2 www.targetmol.com.

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