DOCSLIB.ORG

Pleural and Peritoneal Cavities 95

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Pleural and Peritoneal Cavities 95 94 Maher, Daly Management of bleomycin lung toxicity is immunosuppressive and known steroid spar- frequently difficult, though steroids are wide- ing effects. ly recommended and evidence supporting We believe that all patients with bleomycin their role comes from both animal studies6 lung toxicity should receive a trial of cortico- Thorax: first published as 10.1136/thx.48.1.94 on 1 January 1993. Downloaded from and clinical reports on a few patients.5 steroids. The dose used should depend on the Less settled, however, is the value of these severity of the pneumonitis. agents in advanced bleomycin lung toxicity. Samuels and coworkers7 described a series of 1 Umezawa H, Maeda K, Takeuchi T, Okami Y. New five such patients, all of whom received pred- antibiotics, bleomycin A and B. Journal of Antibiotics (Tokyo) 1966;19:200-9. nisolone in doses of 60-100 mg daily. All five 2 Kuo MT, Haidle CW. Characterization of chain breakage died of acute respiratory failure despite this in DNA induced by bleomycin. Biochem Biophys Acta 1974;335:109-14. treatment. Gilson and Sahn8 reported a 3 Chandler DB. Possible mechanisms of bleomycin-induced patient with bleomycin lung toxicity who fibrosis. In: Cooper J Allen D, ed. Clinics in chest medi- cine. Philadelphia: Saunders, 1990:21-30. developed the adult respiratory distress syn- 4 Holoye PY, Luna MA, Mackay B, Bedrossian CWM. drome after surgery and ultimately responded Bleomycin hypersensitivity pneumonitis. Ann Intern Med 1978; 88:47-9. to a combination of antibiotics and methyl- 5 Jules-Elysee K, White DA. Bleomycin-induced pulmonary prednisolone 500 mg a day. Recently toxicity. In: Cooper J Allen D, ed. Clinics in chest medi- cine. Philadelphia: Saunders, 1990:1-20. Hartmann and colleagues9 also described a 6 Sterling KM, Di Petrillo T, Cutroneo KR, Perstayko A. patient with life threatening bleomycin lung Inhibition of collagen accumulation by glucocorticoids in rat lung after intratracheal bleomycin instillation. toxicity successfully treated with methylpred- Cancer Res 1982;42:405-8. nisolone 1 g daily. Our case, taken in con- 7 Samuels ML, Johnson DE, Holoye PY, Lanzotti VJ. Large dose bleomycin therapy and pulmonary toxicity: a junction with these, suggests that severe possible role of prior radiotherapy. J7AMA 1976;235: bleomycin lung toxicity may be largely 1117-20. 8 Gilson AJ, Sahn SA. Reactivation of bleomycin lung toxic- reversible provided that the treatment regi- ity following oxygen administration. Chest 1985;88: men incorporates corticosteroids in very high 304-6. 9 Hartmann LC, Frytak S, Richardson RL, Coles DT, doses that are tapered gradually. We elected Cupps RE. Life-threatening bleomycin pulmonary toxi- to use azathioprine in addition because of its city with ultimate reversibility. Chest 1990;98:497-9. Thorax 1993;48:94-95 acute perforation of the appendix, and he had Pseudomyxoma of the an appendicectomy at a regional hospital. The wound discharged for two months. Six months pleural and peritoneal later he noticed abdominal swelling. Abdominal ultrasound during his first admis- cavities sion showed massive, loculated ascites without http://thorax.bmj.com/ enlargement or metastatic involvement of G Radosavljevic, B Nedeljkovic, V Kacar abdominal organs. Thoracic computed tomo- graphy showed thickened pleura and a Abstract homogeneous mass in the left hemithorax, Pseudomyxoma peritonei is a rare clini- described as "a dense pleural effusion" (fig 2). cal manifestation of mucin producing Abdominal computed tomography suggested adenocarcinomas. An extensively metas- "mucinous ascites," partly localised around the tased adenocarcinoma developed a liver, following the intestinal curve and con- on September 28, 2021 by guest. Protected copyright. pseudomyxoma that affected not only the centrated in the pelvis. peritoneal cavity but also the pleura. Pleural aspiration on several occasions dis- closed no malignant cells but a few were found (Thorax 1993;48:94-95) in one sample of pleural gelatinous material. A diagnosis of adenocarcinoma was confirmed by Pseudomyxoma peritonei is a rare clinical percutaneous biopsy of the main thoracic mass. entity characterised by mucinous tumour masses in the peritoneum and omentum with gelatinous ascites. It usually originates from adenocarcinoma of the appendix or ovary and less frequently from adenocarcinoma of other organs. 14 Institute for Lung We present a patient with pseudomyxoma Diseases and that affected not only the peritoneum but also Tuberculosis, the University Clinical pleura. Centre, 11000 Belgrade, Vigegradska 26, 11000 Belgrade, Case report Serbia G Radosav1jevic A 41 year old farmer, a non-smoker, was B Nedeljkovic admitted to hospital in December 1988 because V Kacar of mild chest pain and breathlessness, clinical Reprint requests to: signs of ascites, and homogeneous shadowing Dr G Radosavljevic in the left hemithorax on the chest radiograph Received 21 October 1991 Returned to authors (fig 1). His general condition was good. All the 19 December 1991 results of routine laboratory investigations Revised version received 23 January 1992 were within normal limits. Figure 1 Posteroanterior chest radiograph: Accepted 28 January 1992 Two and a half years earlier he had had an homogeneous shadowing in the left hemithorax. Pseudomyxoma of the pleural and peritoneal cavities 95 Figure 2 Thoracic computed tomogram: dense chemotherapy, corticosteroids, and intra- pleural effusion. cavitary hyaluronidase (2000 IU) without any effect. Abdominal paracentesis evacuated only 500 ml of a gelatinous substance. Finally he developed oedema of the lower limbs and Thorax: first published as 10.1136/thx.48.1.94 on 1 January 1993. Downloaded from eventually died in May 1991. Necropsy was not performed. Discussion Pseudomyxoma peritonei was first described in 1894 and there have been reports of a few cases since then.124 The gelatinous material is believed to be produced by a highly differen- tiated mucin producing adenocarcinoma of relatively low malignancy. Treatment of the abdominal condition has included the use of various anticancer drug combinations, hya- luronidase, corticosteroids, repeated palliative surgical treatment, postoperative radiotherapy, Bronchoscopy showed no abnormality. and simple conservative treatment. The Owing to spread of adenocarcinoma within survival ofpatients from the time ofdiagnosis is and beyond the abdomen, surgical treatment over 50% at five years and one patient has was not indicated and he was treated with three survived 24 years.'2 4 courses of doxorubicin (Adriamycin), vincris- The primary tumour in this case was prob- tine, cyclophosphamide, and 5-fluorouracil, but ably in the appendix and the pleural lesion was these had little effect. Thereafter the patient due to metastatic spread. This has not been remained in good general condition for several reported previously. months, during which he was working, though 1 Limber KG, King ER, Silverberg GS. Pseudomyxoma he tired more easily after hard physical work. peritonei. Ann Surg 1973;178:587-93. From August 1989 his condition deterio- 2 Hughes John. Mucocele of the appendix with pseudo- rated, with increasing abdominal myxoma peritonei: a benign or malignant disease? Ann distension, Surg 1967;165:73-6. umbilical and inguinal hernias, and progressive 3 Long TR, Spratt SJ, Dowling E. Pseudomyxoma peritonei. opacification in the left hemithorax with dis- New concepts in management with a report of seventeen patients. Am J Surg 1969:117:162-9. placement of the mediastinum to the right. At 4 Fernandez R, Daly MJ. Pseudomyxoma peritonei. Arch that time the patient received further cytotoxic Surg 1980;115:409-14. http://thorax.bmj.com/ BOOK NOTICE NOTICES Pulmonary function testing. 2nd ed. Reuben M Chemiack. Pp 316; $24-95, £15-95. USA: Harcourt Brace Pathology courses Jovanovich, 1992. ISBN 0-721 6-4014-1. Three courses on pathology will be held in the spring This pocket size, spiral bound second edition contains at the National Heart and Lung Institute: (1) advanced cardiac pathology-the cardiac autopsy, inter- a concise and informative account of basic pulmonary on September 28, 2021 by guest. Protected copyright. physiology and methods of assessing function. preting the cardiac biopsy, recent advances in under- Although it has been revised and expanded since the standing the cardiomyopathies: 29 March 1993; 1977 version there has been little substantive change, (2) lung tumours-cell biology, cytology, pathology, revisions to the text and figures being overall of a cos- radiology, staging, surgery, chemotherapy, radio- metic nature. This new edition has three sections, therapy, diagnosis, prognosis, genetics, oncogenes: starting with basic pulmonary physiology, including 30-31 March 1993; (3) mediastinal tumours-patho- lung mechanics, pulmonary ventilation and circula- logy, radiology, diagnosis, thymomas, lymphomas, tion, control of breathing, and adaptation to exercise. germ cell tumours, cysts, neural tumours, infections, The second section describes a very extensive range of surgery, chemotherapy: 1-2 April 1993. pulmonary function tests and how they may be used For further details please contact Postgraduate to measure the physiological variables introduced in Education Centre, National Heart and Lung Institute, the first section. Each test is described in mainly theo- London SW3 6LY (tel 071 351 8172; fax 071 376 retical terms, though the section on provocation test- 3442). ing, which includes oral agents, deals with practical considerations,
Load more

Recommended publications
  • Hyperthermic Intrathoracic Chemotherapy for Malignant Pleural Mesothelioma: the Forefront of Surgery-Based Multimodality Treatment
    Journal of Clinical Medicine Review Hyperthermic Intrathoracic Chemotherapy for Malignant Pleural Mesothelioma: The Forefront of Surgery-Based Multimodality Treatment Vittorio Aprile 1,†, Alessandra Lenzini 1,†, Filippo Lococo 2, Diana Bacchin 1,* , Stylianos Korasidis 1, Maria Giovanna Mastromarino 1, Giovanni Guglielmi 3, Gerardo Palmiero 4, Marcello Carlo Ambrogi 1 and Marco Lucchi 1 1 Unit of Thoracic Surgery, Department of Critical Area and Surgical, Medical and Molecular Pathology, University of Pisa, 56122 Pisa, Italy; [email protected] (V.A.); [email protected] (A.L.); [email protected] (S.K.); [email protected] (M.G.M.); [email protected] (M.C.A.); [email protected] (M.L.) 2 Thoracic Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy; fi[email protected] 3 Occupational Health Department, U.O. Medicina Preventiva del Lavoro, Azienda Ospedaliero-Universitaria Pisana, 56122 Pisa, Italy; [email protected] 4 Pneumology Unit, Versilia Hospital, 55049 Camaiore, Italy; [email protected] * Correspondence: [email protected]; Tel.: +39-0-5099-5230 † These authors contributed equally to this work. Abstract: Introduction: Malignant Pleural Mesothelioma (MPM) is characterized by an aggressive Citation: Aprile, V.; Lenzini, A.; behavior and an inevitably fatal prognosis, whose treatment is still far from being standardized. The Lococo, F.; Bacchin, D.; Korasidis, S.; role of surgery is questionable since a radical resection is unattainable in most cases. Hyperthermic Mastromarino, M.G.; Guglielmi, G.; IntraTHOracic Chemotherapy (HITHOC) combines the advantages of antitumoral effects together Palmiero, G.; Ambrogi, M.C.; Lucchi, with those of high temperature on the exposed tissues with the aim to improve surgical radicality.
    [Show full text]
  • Pseudo-Pseudomyxoma Peritonei from Peritoneal Sarcomatosis
    http://crcp.sciedupress.com Case Reports in Clinical Pathology, 2015, Vol. 2, No. 4 CASE REPORT Pseudo-pseudomyxoma peritonei from peritoneal sarcomatosis Shuja Ahmed1, Ling Guo2, Shadi A. Qasem2, Edward A. Levine1 1. Surgical Oncology Service, Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, NC, USA. 2. Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA. Correspondence: Edward A. Levine, MD. Address: Surgical Oncology Service, Medical Center Blvd, Winston-Salem, North Carolina, USA. E-mail: [email protected] Received: February 12, 2015 Accepted: April 12, 2015 Online Published: June 3, 2015 DOI: 10.5430/crcp.v2n4p14 URL: http://dx.doi.org/10.5430/crcp.v2n4p14 Abstract Background: Pseudomyxoma peritonei (PMP) is a rare clinical entity of mucinous ascites, most commonly associated with appendiceal mucinous neoplasms. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) remains the current standard of care for PMP. Peritoneal sarcomatosis (PS) is an exceptionally rare disease with a poor prognosis. PMP associated with PS has not been previously described. The role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for PS with or without PMP is not well-defined. PS manifesting like PMP has not been previously described. Case presentation: A 74-year-old patient with several weeks history of vague abdominal pain and increased abdominal girth was referred to our facility after incidental finding of PMP during laparoscopic inguinal hernia repair. After complete work-up, he was advised to undergo CRS/HIPEC. Intra-operatively, he was noted to have extensive mucinous ascites and underwent aggressive CRS and HIPEC Result: Final pathology revealed myxoid liposarcoma with associated intraperitoneal mucin dissemination, which was confirmed with cytogenetic analysis.
    [Show full text]
  • Appendix Cancer and Pseudomyxoma Peritonei (PMP) a Guide for People Affected by Cancer
    Cancer information fact sheet Understanding Appendix Cancer and Pseudomyxoma Peritonei (PMP) A guide for people affected by cancer This fact sheet has been prepared What is appendix cancer? to help you understand more about Appendix cancer occurs when cells in the appendix appendix cancer and pseudomyxoma become abnormal and keep growing and form a peritonei (PMP). mass or lump called a tumour. Many people look for support after The type of cancer is defined by the particular being diagnosed with a cancer that cells that are affected and can be benign (non- is rare or less common than other cancerous) or malignant (cancerous). Malignant cancer types. This fact sheet includes tumours have the potential to spread to other information about how these cancers parts of the body through the blood stream or are diagnosed and treated, as well as lymph vessels and form another tumour at a where to go for additional information new site. This new tumour is known as secondary and support services. cancer or metastasis. Many people feel shocked and upset when told they have cancer. You may experience strong emotions The abdomen after a cancer diagnosis, especially if your cancer is rare or less common like appendix cancer or PMP. A feeling of being alone is usual with rare cancers, and you might be worried about how much is known about your type of cancer as well as how it will be managed. You may also be concerned about the cancer coming back after treatment. Linking into local support services (see last page) can help overcome feelings of isolation and will give you information that you may find useful.
    [Show full text]
  • Ovarian Carcinomas, Including Secondary Tumors: Diagnostically Challenging Areas
    Modern Pathology (2005) 18, S99–S111 & 2005 USCAP, Inc All rights reserved 0893-3952/05 $30.00 www.modernpathology.org Ovarian carcinomas, including secondary tumors: diagnostically challenging areas Jaime Prat Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain The differential diagnosis of ovarian carcinomas, including secondary tumors, remains a challenging task. Mucinous carcinomas of the ovary are rare and can be easily confused with metastatic mucinous carcinomas that may present clinically as a primary ovarian tumor. Most of these originate in the gastrointestinal tract and pancreas. International Federation of Gynecology and Obstetrics (FIGO) stage is the single most important prognostic factor, and stage I carcinomas have an excellent prognosis; FIGO stage is largely related to the histologic features of the ovarian tumors. Infiltrative stromal invasion proved to be biologically more aggressive than expansile invasion. Metastatic colon cancer is frequent and often simulates ovarian endometrioid adenocarcinoma. Although immunostains for cytokeratins 7 and 20 can be helpful in the differential diagnosis, they should always be interpreted in the light of all clinical information. Occasionally, endometrioid carcinomas may exhibit a microglandular pattern simulating sex cord-stromal tumors. However, typical endometrioid glands, squamous differentiation, or an adenofibroma component are each present in 75% of these tumors whereas immunostains for calretinin and alpha-inhibin are negative. Endometrioid carcinoma of the ovary is associated in 15–20% of the cases with carcinoma of the endometrium. Most of these tumors have a favorable outcome and they most likely represent independent primary carcinomas arising as a result of a Mu¨ llerian field effect.
    [Show full text]
  • Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies: Learning Curve Based on Surgical and Oncological Outcomes
    cancers Article Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies: Learning Curve Based on Surgical and Oncological Outcomes Jerzy Mielko, Karol Rawicz-Pruszy ´nski* , Katarzyna S˛edłak,Katarzyna G˛eca, Magdalena Kwietniewska and Wojciech P. Polkowski Department of Surgical Oncology, Medical University of Lublin, Radziwiłłowska 13 St., 20-080 Lublin, Poland; [email protected] (J.M.); [email protected] (K.S.); [email protected] (K.G.); [email protected] (M.K.); [email protected] (W.P.) * Correspondence: [email protected]; Tel.: +48-881318964 Received: 29 June 2020; Accepted: 21 August 2020; Published: 23 August 2020 Keywords: CRS + HIPEC; peritoneal surface malignancies; learning curve 1. Introduction Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex, highly specialized procedure used to treat peritoneal surface malignancies (PSM) [1–4]. The PSM includes both rare diseases of the peritoneum (pseudomyxoma peritonei, peritoneal mesothelioma) as well as metastases from various primary cancers (ovarian, colorectal, gastric, etc.) to the surface of peritoneum. Despite initial skepticism, CRS + HIPEC has become a widely accepted procedure in the treatment of pseudomyxoma peritonei, appendiceal cancer, metastatic colorectal cancer, and peritoneal mesothelioma [5–10]. Significant improvement in oncological results has also been reported in peritoneal dissemination from gastric and ovarian cancers compared to palliative treatment [11,12]. Achieving complete cytoreduction often requires extensive surgical procedure with multiple anastomoses, associated with relatively high complication rates (14–70%) [13]. In reference centers, perioperative mortality reaches 8%. This high rate has been attributed to the learning curve (LC), and it decreases after about 100–140 operations [14–18].
    [Show full text]
  • A Rare Cause of Painless Haematuria- Adenocarcinoma of Appendix
    Ju ry [ rnal e ul rg d u e S C f h o i l r u a Journal of Surgery r n g r i u e o ] J ISSN: 1584-9341 [Jurnalul de Chirurgie] Case Report Open Access A Rare Cause of Painless Haematuria- Adenocarcinoma of Appendix Shantanu Kumar Sahu1*, Shikhar Agarwal2, Sanjay Agrawal3, Shailendra Raghuvanshi4, Nadia Shirazi5, Saurabh Agrawal1 and Uma Sharma1 1Department of General Surgery, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India 2Department of Urology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India 3Department of Anesthesia, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India 4Department of Radiodiagnosis, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India 5Department of Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India Abstract Neoplasms of the appendix are rare, accounting for less than 0.5% of all gastrointestinal malignancies and found incidentally in approximately 1% of appendectomy specimen. Carcinoids are the most common appendicular tumors, accounting for approximately 66%, with cystadenocarcinoma accounting for 20% and adenocarcinoma accounting for 10%. Appendiceal adenocarcinomas fall into one of three separate histologic types. The most common mucinous type produces abundant mucin, the less common intestinal or colonic type closely mimics adenocarcinomas found in the colon, and the least common, signet ring cell adenocarcinoma, is quite virulent and associated with a poor prognosis. Adenocarcinoma of appendix is most frequently perforating tumour of gastrointestinal tract due to anatomical peculiarity of appendix which has an extremely thin subserosal and peritoneal coat and the thinnest muscle layer of the whole gastrointestinal tract.
    [Show full text]
  • Hyperthermic Intrathoracic Chemotherapy (HITHOC) for Pleural Malignancies—Experience from Indian Centers
    Indian Journal of Surgical Oncology (February 2019) 10 (Suppl 1):S91–S98 https://doi.org/10.1007/s13193-018-0859-y ORIGINAL ARTICLE Hyperthermic Intrathoracic Chemotherapy (HITHOC) for Pleural Malignancies—Experience from Indian Centers Mahesh D. Patel1 & Dileep Damodaran2 & Ashvin Rangole3 & Sakina Shaikh1 & Kairav Shah4 & Rajendra Bagwade4 & Aditi Bhatt1 Received: 14 November 2018 /Accepted: 4 December 2018 /Published online: 11 December 2018 # Indian Association of Surgical Oncology 2018 Abstract Hyperthermic intrathoracic chemotherapy (HITHOC) has been used in addition to radical surgery for primary and secondary pleural malignancies to improve local control, prolong survival, and improve the quality of life. This study was performed to study the indications, methodology, perioperative outcomes, and survival in patients undergoing HITHOC at Indian centers. A retrospective analysis of prospectively collected demographic and clinical data, perioperative and survival data of patients undergoing surgery with or without HITHOC was performed. From January 2011 to May 2018, seven patients underwent pleurectomy/decortication (P/D) or extrapleural pneumonectomy (EPP) with HITHOC and four had P/D or EPP alone at three Indian centers. P/D was performed in two and EPP in nine patients. The primary tumor was pleural mesothelioma in eight, metastases from thymoma in one, germ cell tumor in one, and solitary fibrous tumor of the pleura in one. HITHOC was performed using cisplatin. Grade 3–4 complications were seen in one patient in the HITHOC group and none in the non- HITHOC group, and one patient in the non-HITHOC group died of complications. At a median follow-up of 9 months, five patients of the HITHOC group were alive, four without recurrence, and one with recurrence.
    [Show full text]
  • In Vivo Model of Pseudomyxoma Peritonei for Novel Candidate Drug Discovery
    ANTICANCER RESEARCH 29: 4051-4056 (2009) In Vivo Model of Pseudomyxoma Peritonei for Novel Candidate Drug Discovery TERENCE C. CHUA, JAVED AKTHER, PENG YAO and DAVID L. MORRIS Department of Surgery, University of New South Wales, St. George Hospital, Kogarah, Sydney, NSW 2217, Australia Abstract. Pseudomyxoma peritonei (PMP) is a clinical mucinous implants accumulating in the pelvis and condition characterized by diffuse intraabdominal spread of subphrenic regions are often daunting to general surgeons mucinous tumor implants that form on peritoneal surfaces. To (2). Traditional treatments include repeated abdominal complement the efficacy of cytoreductive surgery, an effective lavage of mucin, limited debulking of tumor and systemic cytotoxic drug is required as an intraperitoneal agent for chemotherapy (3). However, these treatments are unable to microscopic cytoreduction locoregionally. To develop a model adequately combat the reaccumulation of mucin that for drug discovery, human pseudomyxoma peritonei tumor characterizes the failure of these treatments. implants consisting of a mixture of mucin and epithelial cells Over the last two decades, cytoreductive surgery and were injected into the peritoneal cavity of CBH/rnu/rnu rats. perioperative intraperitoneal chemotherapy comprising of A fixed quantity of tumor (2 ml) was implanted in each of the hyperthermic intraperitoneal chemotherapy (HIPEC) using 9 male rats. Over 90 days, all rats developed PMP indicating mitomycin C with or without postoperative intraperitoneal that this in vivo animal model may become useful platform in chemotherapy (EPIC) using 5-fluorouracil has emerged to a drug discovery program to allow drug efficacy testing become the standard of care in specialized centers (4, 5). A against human PMP.
    [Show full text]
  • An Uncommon Cause of Isolated Ascites: Pseudomyxoma Peritonei ISSN 2640-2750 Louly Hady1*, I Nassar2, K Znati3 and N Kabbaj1
    Open Access Annals of Clinical Gastroenterology and Hepatology Case Report An uncommon cause of isolated ascites: Pseudomyxoma peritonei ISSN 2640-2750 Louly Hady1*, I Nassar2, K Znati3 and N Kabbaj1 1EFD-HGE Department, Ibn Sina Hospital, Rabat, Morocco 2Central Radiology Department, Ibn Sina Hospital, Rabat, Morocco 3Central Anatomical Pathology Department, Ibn Sina Hospital, Rabat, Morocco *Address for Correspondence: Louly Hady, Summary EFD-HGE Department, Ibn Sina Hospital, Rabat, Morocco, Email: [email protected] Pseudomyxoma peritonei or Gelatinous Peritoneal Disease is a rare disease. We report a Submitted: 15 April 2019 case treated in the department of Hepato-Gastroenterology at Ibn Sina Hospital in Rabat, of a Approved: 25 April 2019 64-year-old male who presented with an abdominal pain and an increased volume of the abdomen Published: 26 April 2019 corresponding to ascites. Imaging and anatomopathological study made it possible to diagnose the disease. However, given the general state of the patient, he is under palliative care. Copyright: © 2019 Hady L, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction Introduction in any medium, provided the original work is properly cited Pseudomyxoma peritonei (PMP) or Gelatinous Peritoneal Disease is a rare condition that refers to an anatomo-clinical entity characterized by ascites of variable abundance Keywords: Ascites; Appendix mucocele; Pseudomyxoma peritonei in the peritoneal cavity, viscous or mucinous, associated or not with neoplastic epithelial cells. It predominates in women. Diagnosis is guided by imaging and conirmed by histology. Prognosis is good in case of early management.
    [Show full text]
  • Second Revised Proposed Regulation of the State
    SECOND REVISED PROPOSED REGULATION OF THE STATE BOARD OF HEALTH LCB File No. R057-16 February 5, 2018 EXPLANATION – Matter in italics is new; matter in brackets [omitted material] is material to be omitted. AUTHORITY: §§1, 2, 4-9 and 11-15, NRS 457.065 and 457.240; §3, NRS 457.065 and 457.250; §10, NRS 457.065; §16, NRS 439.150, 457.065, 457.250 and 457.260. A REGULATION relating to cancer; revising provisions relating to certain publications adopted by reference by the State Board of Health; revising provisions governing the system for reporting information on cancer and other neoplasms established and maintained by the Chief Medical Officer; establishing the amount and the procedure for the imposition of certain administrative penalties by the Division of Public and Behavioral Health of the Department of Health and Human Services; and providing other matters properly relating thereto. Legislative Counsel’s Digest: Existing law defines the term “cancer” to mean “all malignant neoplasms, regardless of the tissue of origin, including malignant lymphoma and leukemia” and, before the 78th Legislative Session, required the reporting of incidences of cancer. (NRS 457.020, 457.230) Pursuant to Assembly Bill No. 42 of the 78th Legislative Session, the State Board of Health is: (1) authorized to require the reporting of incidences of neoplasms other than cancer, in addition to incidences of cancer, to the system for reporting such information established and maintained by the Chief Medical Officer; and (2) required to establish an administrative penalty to impose against any person who violates certain provisions which govern the abstracting of records of a health care facility relating to the neoplasms the Board requires to be reported.
    [Show full text]
  • Appendiceal Neoplasia and Pseudomyxoma Peritonei
    06/08/2019 Correct diagnosis is important • Patients may have prolonged follow-up • PMP may be treated with cytoreductive surgery Appendiceal neoplasia and and heated intraperitoneal chemotherapy (HIPEC) pseudomyxoma peritonei Norman Carr Harrogate 2019 Classification has been confusing and Content inconsistent • Recent consensus: • Pseudomyxoma peritonei • Mucinous appendiceal neoplasms • Goblet cell carcinoid 1 06/08/2019 What is pseudomyxoma peritonei? Most PMP arises from an appendiceal • A syndrome of mucinous mucinous neoplasm tumour within the Other primary sites: abdomen – ovarian teratoma – tends not to – colon invade/metastasise – urachus – grows slowly but relentlessly – IPMN – death is usually by – cervix intestinal obstruction – renal pelvis Pseudomyxoma peritonei: classification Acellular intra-abdominal mucin 1. Acellular mucin • Can be a feature of PMP – in TNM8 for the appendix, acellular 2. Low grade mucinous carcinoma mucin within the abdominal cavity peritonei is classified pM1a 3. High grade mucinous carcinoma – better prognosis peritonei • But other causes exist (e.g. ruptured 4. High grade mucinous carcinoma cystadenoma of ovary) peritonei with signet ring cells Davison JM et al 2014, Shetty S et al 2013, Sirintrapun SJ et al 2014 2 06/08/2019 Pseudomyxoma peritonei Pseudomyxoma peritonei • Low grade mucinous carcinoma • High grade mucinous carcinoma peritonei (disseminated peritonei with signet ring cells peritoneal adenomucinosis – (PMCA-S) DPAM) – worse prognosis • High grade mucinous carcinoma • 10% threshold
    [Show full text]
  • II.F) Peritoneal Mesothelioma and Pseudomyxoma Peritonei D01
    Supplemental Congress Abstracts – PSOGI 2018, Paris, September 9–11, 2018 • https://doi.org/10.1515/pap-2018-7021 sA348 Pleura and Peritoneum 2018; 1, Special Suppl, pp sA6–sA463, September 2018 • Copyright © 2018 Walter de Gruyter GmbH, Berlin / Boston II.f) Peritoneal mesothelioma and pseudomyxoma peritonei D01 ADJUVANT DENDRITIC CELL BASED IMMUNOTHERAPY (DCBI) AFTER CYTOREDUCTIVE SURGERY (CRS) AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (HIPEC) FOR PERITONEAL MESOTHELIOMA: RATIONALE AND DESIGN OF THE MESOPEC STUDY N.L. De Boer1, J. Van Kooten1, A. Brandt1, C. Verhoef1, J.W. Burger1, J.G. Aerts2, E.V. Madsen1 1Department of Surgical Oncology, Erasmus MC Cancer Institute - Rotterdam (Netherlands), 2Department of Pulmonary Medicine, Erasmus MC Cancer Institute - Rotterdam (Netherlands) Objectives Malignant peritoneal mesothelioma (MPM) is an uncommon but aggressive neoplasm and has an association with asbestos exposure. MPM has low survival rates of approximately one year even after palliative surgery and/or systemic chemotherapy. Recent advances in treatment strategies focusing on cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have resulted in improved median survival of 53 months and a 5-year survival of nearly 50%. However, recurrence rates are high. Current systemic chemotherapy in the adjuvant setting is of limited efficacy, while immunotherapy with dendritic cell based immunotherapy (DCBI) has yielded promising results in murine models with peritoneal mesothelioma and in patients with pleural mesothelioma. The goal of the study is to assess the feasibility of administering DCBI after CRS-HIPEC in patients with MPM. Secondary objective of this study is to assess safety in patients with peritoneal mesothelioma who are treated with DCBI, which has already been proven in patients with pleural mesothelioma.
    [Show full text]